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Aliases for SLITRK2 Gene

Aliases for SLITRK2 Gene

  • SLIT And NTRK Like Family Member 2 2 3 5
  • SLIT And NTRK-Like Family, Member 2 2 3
  • SLITL1 3 4
  • CXorf2 3 4
  • Slit-Like 1 (Drosophila) 2
  • Slit And Trk Like Gene 2 3
  • Slit-Like 1 3
  • KIAA1854 4

External Ids for SLITRK2 Gene

Previous HGNC Symbols for SLITRK2 Gene

  • SLITL1

Previous GeneCards Identifiers for SLITRK2 Gene

  • GC0XP143567
  • GC0XP144604
  • GC0XP144707
  • GC0XP144900
  • GC0XP133868

Summaries for SLITRK2 Gene

Entrez Gene Summary for SLITRK2 Gene

  • This gene encodes an integral membrane protein that contains two N-terminal leucine-rich repeats domains and contains C-terminal regions similar to neurotrophin receptors. The encoded protein may play a role in modulating neurite activity. Alternatively spliced transcript variants encoding the same protein have been described.[provided by RefSeq, Feb 2010]

GeneCards Summary for SLITRK2 Gene

SLITRK2 (SLIT And NTRK Like Family Member 2) is a Protein Coding gene. An important paralog of this gene is SLITRK4.

UniProtKB/Swiss-Prot for SLITRK2 Gene

  • Suppresses neurite outgrowth.

Gene Wiki entry for SLITRK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLITRK2 Gene

Genomics for SLITRK2 Gene

Regulatory Elements for SLITRK2 Gene

Genomic Location for SLITRK2 Gene

145,817,829 bp from pter
145,825,842 bp from pter
8,014 bases
Plus strand

Genomic View for SLITRK2 Gene

Genes around SLITRK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLITRK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLITRK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLITRK2 Gene

Proteins for SLITRK2 Gene

  • Protein details for SLITRK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SLIT and NTRK-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K117
    • Q2KHN3
    • Q5JXB1
    • Q8NBC7
    • Q96JH3

    Protein attributes for SLITRK2 Gene

    845 amino acids
    Molecular mass:
    95404 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB47483.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLITRK2 Gene


neXtProt entry for SLITRK2 Gene

Proteomics data for SLITRK2 Gene at MOPED

Post-translational modifications for SLITRK2 Gene

  • Glycosylation at Asn 84 and Asn 421
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SLITRK2 Gene

Domains & Families for SLITRK2 Gene

Protein Domains for SLITRK2 Gene

Suggested Antigen Peptide Sequences for SLITRK2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 LRRCT domains.
  • Belongs to the SLITRK family.
  • Contains 12 LRR (leucine-rich) repeats.
  • Contains 2 LRRCT domains.
  • Contains 1 LRRNT domain.
  • Belongs to the SLITRK family.
  • Contains 12 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with SLITRK2: view

No data available for Gene Families for SLITRK2 Gene

Function for SLITRK2 Gene

Molecular function for SLITRK2 Gene

UniProtKB/Swiss-Prot Function:
Suppresses neurite outgrowth.

Phenotypes for SLITRK2 Gene

genes like me logo Genes that share phenotypes with SLITRK2: view

Animal Model Products

CRISPR Products

miRNA for SLITRK2 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLITRK2 Gene

Localization for SLITRK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLITRK2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SLITRK2 Gene COMPARTMENTS Subcellular localization image for SLITRK2 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SLITRK2 Gene

Pathways & Interactions for SLITRK2 Gene

SuperPathways for SLITRK2 Gene

No Data Available

Interacting Proteins for SLITRK2 Gene

Gene Ontology (GO) - Biological Process for SLITRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051965 positive regulation of synapse assembly IEA --
genes like me logo Genes that share ontologies with SLITRK2: view

No data available for Pathways by source and SIGNOR curated interactions for SLITRK2 Gene

Drugs & Compounds for SLITRK2 Gene

No Compound Related Data Available

Transcripts for SLITRK2 Gene

Unigene Clusters for SLITRK2 Gene

SLIT and NTRK-like family, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLITRK2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - -
SP2: - - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6: - - -

Relevant External Links for SLITRK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLITRK2 Gene

mRNA expression in normal human tissues for SLITRK2 Gene

mRNA differential expression in normal tissues according to GTEx for SLITRK2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.8), Brain - Caudate (basal ganglia) (x4.4), and Brain - Amygdala (x4.0).

Protein differential expression in normal tissues from HIPED for SLITRK2 Gene

This gene is overexpressed in Bone (62.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLITRK2 Gene

SOURCE GeneReport for Unigene cluster for SLITRK2 Gene Hs.320368

mRNA Expression by UniProt/SwissProt for SLITRK2 Gene

Tissue specificity: Expressed predominantly in the cerebral cortex of the brain but also at low levels in the spinal cord and medulla. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors.
genes like me logo Genes that share expression patterns with SLITRK2: view

Protein tissue co-expression partners for SLITRK2 Gene

Primer Products

Orthologs for SLITRK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLITRK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLITRK2 35
  • 88.98 (n)
  • 97.16 (a)
  • 97 (a)
(Canis familiaris)
Mammalia SLITRK2 35
  • 91.24 (n)
  • 98.34 (a)
  • 98 (a)
(Mus musculus)
Mammalia Slitrk2 35
  • 90.77 (n)
  • 97.63 (a)
Slitrk2 16
Slitrk2 36
  • 97 (a)
(Pan troglodytes)
Mammalia SLITRK2 35
  • 99.52 (n)
  • 99.52 (a)
(Rattus norvegicus)
Mammalia Slitrk2 35
  • 90.65 (n)
  • 97.63 (a)
(Ornithorhynchus anatinus)
Mammalia SLITRK2 36
  • 90 (a)
(Gallus gallus)
Aves SLITRK2 35
  • 77.63 (n)
  • 84.97 (a)
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slitrk2 35
  • 74.6 (n)
  • 83.2 (a)
(Danio rerio)
Actinopterygii slitrk2 35
  • 68.61 (n)
  • 74.23 (a)
slitrk2 36
  • 73 (a)
Species with no ortholog for SLITRK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLITRK2 Gene

Gene Tree for SLITRK2 (if available)
Gene Tree for SLITRK2 (if available)

Paralogs for SLITRK2 Gene

Paralogs for SLITRK2 Gene

(8) SIMAP similar genes for SLITRK2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLITRK2: view

Variants for SLITRK2 Gene

Sequence variations from dbSNP and Humsavar for SLITRK2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs2295336 - 145,824,226(+) CTCGG(C/T)CGCTT reference, missense
rs2495264 -- 145,820,106(+) ATCTA(A/T)TCCAC intron-variant, upstream-variant-2KB
rs2495265 -- 145,820,206(+) ATTCC(C/T)TCCTT intron-variant, upstream-variant-2KB
rs2748588 -- 145,823,364(+) ACTCC(C/T)CGAGT reference, synonymous-codon
rs2748589 -- 145,823,427(+) AAGTC(C/T)CCTGT reference, synonymous-codon

Variation tolerance for SLITRK2 Gene

Residual Variation Intolerance Score: 2.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.81; 66.95% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for SLITRK2 Gene

Disorders for SLITRK2 Gene

Relevant External Links for SLITRK2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLITRK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLITRK2 Gene

Publications for SLITRK2 Gene

  1. Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. (PMID: 14557068) Aruga J. … Mikoshiba K. (Gene 2003) 2 3 4 23 67
  2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3
  3. Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia. (PMID: 20479760) Piton A. … Rouleau G.A. (Mol. Psychiatry 2011) 3
  4. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3
  5. Genome-wide association study of bipolar disorder in European American and African American individuals. (PMID: 19488044) Smith E.N. … Kelsoe J.R. (Mol. Psychiatry 2009) 3

Products for SLITRK2 Gene

Sources for SLITRK2 Gene