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Aliases for SLITRK2 Gene

Aliases for SLITRK2 Gene

  • SLIT And NTRK-Like Family, Member 2 2 3
  • KIAA1854 4 6
  • SLITL1 3 4
  • CXorf2 3 4
  • SLIT And NTRK-Like Protein 2 3
  • Slit-Like 1 (Drosophila) 2
  • Slit And Trk Like Gene 2 3
  • Slit-Like 1 3

External Ids for SLITRK2 Gene

Previous HGNC Symbols for SLITRK2 Gene

  • SLITL1

Previous GeneCards Identifiers for SLITRK2 Gene

  • GC0XP143567
  • GC0XP144604
  • GC0XP144707
  • GC0XP144900
  • GC0XP133868

Summaries for SLITRK2 Gene

Entrez Gene Summary for SLITRK2 Gene

  • This gene encodes an integral membrane protein that contains two N-terminal leucine-rich repeats domains and contains C-terminal regions similar to neurotrophin receptors. The encoded protein may play a role in modulating neurite activity. Alternatively spliced transcript variants encoding the same protein have been described.[provided by RefSeq, Feb 2010]

GeneCards Summary for SLITRK2 Gene

SLITRK2 (SLIT And NTRK-Like Family, Member 2) is a Protein Coding gene. Diseases associated with SLITRK2 include autism spectrum disorder. An important paralog of this gene is SLITRK3.

UniProtKB/Swiss-Prot for SLITRK2 Gene

  • Suppresses neurite outgrowth.

Gene Wiki entry for SLITRK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLITRK2 Gene

Genomics for SLITRK2 Gene

Regulatory Elements for SLITRK2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLITRK2 Gene

Start:
145,817,829 bp from pter
End:
145,825,842 bp from pter
Size:
8,014 bases
Orientation:
Plus strand

Genomic View for SLITRK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLITRK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLITRK2 Gene

Proteins for SLITRK2 Gene

  • Protein details for SLITRK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H156-SLIK2_HUMAN
    Recommended name:
    SLIT and NTRK-like protein 2
    Protein Accession:
    Q9H156
    Secondary Accessions:
    • A8K117
    • Q2KHN3
    • Q5JXB1
    • Q8NBC7
    • Q96JH3

    Protein attributes for SLITRK2 Gene

    Size:
    845 amino acids
    Molecular mass:
    95404 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47483.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLITRK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLITRK2 Gene

Proteomics data for SLITRK2 Gene at MOPED

Post-translational modifications for SLITRK2 Gene

  • Glycosylation at Asn84 and Asn421
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SLITRK2 Gene

Domains for SLITRK2 Gene

Protein Domains for SLITRK2 Gene

Suggested Antigen Peptide Sequences for SLITRK2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H156

UniProtKB/Swiss-Prot:

SLIK2_HUMAN :
  • Q9H156
Domain:
  • Contains 2 LRRCT domains.
  • Contains 1 LRRNT domain.
Family:
  • Belongs to the SLITRK family.
Similarity:
  • Contains 12 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with SLITRK2: view

No data available for Gene Families for SLITRK2 Gene

Function for SLITRK2 Gene

Molecular function for SLITRK2 Gene

UniProtKB/Swiss-Prot Function: Suppresses neurite outgrowth.

Gene Ontology (GO) - Molecular Function for SLITRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SLITRK2: view

Phenotypes for SLITRK2 Gene

GenomeRNAi human phenotypes for SLITRK2:
genes like me logo Genes that share phenotypes with SLITRK2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLITRK2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLITRK2 Gene

Localization for SLITRK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLITRK2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLITRK2 Gene COMPARTMENTS Subcellular localization image for SLITRK2 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLITRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLITRK2: view

Pathways for SLITRK2 Gene

SuperPathways for SLITRK2 Gene

No Data Available

Interacting Proteins for SLITRK2 Gene

Gene Ontology (GO) - Biological Process for SLITRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007409 axonogenesis IEA --
genes like me logo Genes that share ontologies with SLITRK2: view

No data available for Pathways by source for SLITRK2 Gene

Transcripts for SLITRK2 Gene

Unigene Clusters for SLITRK2 Gene

SLIT and NTRK-like family, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLITRK2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLITRK2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLITRK2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - -
SP2: - - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6: - - -

Relevant External Links for SLITRK2 Gene

GeneLoc Exon Structure for
SLITRK2
ECgene alternative splicing isoforms for
SLITRK2

Expression for SLITRK2 Gene

mRNA expression in normal human tissues for SLITRK2 Gene

mRNA differential expression in normal tissues according to GTEx for SLITRK2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (4.8), Brain - Caudate (basal ganglia) (4.4), and Brain - Amygdala (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLITRK2 Gene

SOURCE GeneReport for Unigene cluster for SLITRK2 Gene Hs.320368

mRNA Expression by UniProt/SwissProt for SLITRK2 Gene

Q9H156-SLIK2_HUMAN
Tissue specificity: Expressed predominantly in the cerebral cortex of the brain but also at low levels in the spinal cord and medulla. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors.
genes like me logo Genes that share expressions with SLITRK2: view

In Situ Assay Products

Orthologs for SLITRK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLITRK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLITRK2 35
  • 99.52 (n)
  • 99.52 (a)
cow
(Bos Taurus)
Mammalia SLITRK2 35
  • 88.98 (n)
  • 97.16 (a)
SLITRK2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLITRK2 35
  • 91.24 (n)
  • 98.34 (a)
SLITRK2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slitrk2 35
  • 90.77 (n)
  • 97.63 (a)
Slitrk2 16
Slitrk2 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLITRK2 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slitrk2 35
  • 90.65 (n)
  • 97.63 (a)
chicken
(Gallus gallus)
Aves SLITRK2 35
  • 77.63 (n)
  • 84.97 (a)
SLITRK2 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slitrk2 35
  • 74.6 (n)
  • 83.2 (a)
zebrafish
(Danio rerio)
Actinopterygii slitrk2 35
  • 68.61 (n)
  • 74.23 (a)
slitrk2 36
  • 73 (a)
OneToOne
Species with no ortholog for SLITRK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLITRK2 Gene

ENSEMBL:
Gene Tree for SLITRK2 (if available)
TreeFam:
Gene Tree for SLITRK2 (if available)

Paralogs for SLITRK2 Gene

Selected SIMAP similar genes for SLITRK2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLITRK2: view

Variants for SLITRK2 Gene

Sequence variations from dbSNP and Humsavar for SLITRK2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2295336 - 145,824,226(+) CTCGG(C/T)CGCTT missense, reference
rs2495264 -- 145,820,106(+) ATCTA(A/T)TCCAC intron-variant, upstream-variant-2KB
rs2495265 -- 145,820,206(+) ATTCC(C/T)TCCTT intron-variant, upstream-variant-2KB
rs2748588 -- 145,823,364(+) ACTCC(C/T)CGAGT synonymous-codon, reference
rs2748589 -- 145,823,427(+) AAGTC(C/T)CCTGT synonymous-codon, reference

Relevant External Links for SLITRK2 Gene

HapMap Linkage Disequilibrium report
SLITRK2
Locus Specific Mutation Databases (LSDB)
SLITRK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLITRK2 Gene

Disorders for SLITRK2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SLITRK2 Gene including...

Search for SLITRK2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SLITRK2 Gene

Relevant External Links for SLITRK2

Genetic Association Database (GAD)
SLITRK2
Human Genome Epidemiology (HuGE) Navigator
SLITRK2
genes like me logo Genes that share disorders with SLITRK2: view

No data available for UniProtKB/Swiss-Prot for SLITRK2 Gene

Publications for SLITRK2 Gene

  1. Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. (PMID: 14557068) Aruga J. … Mikoshiba K. (Gene 2003) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SLITRK2 Gene

Sources for SLITRK2 Gene

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