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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLITRK1 Gene

protein-coding   GIFtS: 59
GCID: GC13M084451

SLIT And NTRK-Like Family, Member 1

(Previous name: leucine rich repeat containing 12)
(Previous symbol: LRRC12)
  17 related diseases
at
MalaCards
 

Aliases
for SLITRK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
SLIT And NTRK-Like Family, Member 11 2     KIAA19103 5
LRRC121 2 3     Leucine Rich Repeat Containing 121
Leucine-Rich Repeat-Containing Protein 122 3     SLIT And NTRK-Like Protein 12
TTM2 5     Slit And Trk Like Gene 12

External Ids:    HGNC: 202971   Entrez Gene: 1147982   Ensembl: ENSG000001782357   OMIM: 6096785   UniProtKB: Q96PX83   

Export aliases for SLITRK1 gene to outside databases

Previous GC identifers: GC13M082251 GC13M082249 GC13M083349 GC13M065151


Summaries
for SLITRK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLITRK1 Gene:
This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are
characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with
trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin
receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with
Tourette syndrome. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for SLITRK1 Gene: 
SLITRK1 (SLIT and NTRK-like family, member 1) is a protein-coding gene. Diseases associated with SLITRK1 include tourette disorder, and trichotillomania. An important paralog of this gene is SLITRK2.

UniProtKB/Swiss-Prot: SLIK1_HUMAN, Q96PX8
Function: Enhances neuronal dendrite outgrowth

Gene Wiki entry for SLITRK1 Gene


Genomic Views
for SLITRK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLITRK1 gene promoter:
         STAT1   STAT1beta   Nkx2-5   CUTL1   STAT1alpha   SRY   POU2F1   POU2F1a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLITRK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLITRK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLITRK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q31.1   Ensembl cytogenetic band:  13q31.1   HGNC cytogenetic band: 13q31.1

SLITRK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLITRK1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M084451:  view genomic region     (about GC identifiers)

Start:
 84,451,343 bp from pter      End:
 84,456,528 bp from pter
Size:
 5,186 bases      Orientation:
 minus strand

Proteins
for SLITRK1 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: SLIK1_HUMAN, Q96PX8 (See protein sequence)
Recommended Name: SLIT and NTRK-like protein 1 precursor  
Size: 696 amino acids; 77735 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Developmental stage: At 20 weeks of gestation, expressed in multiple brain regions, including the developing
neo-cortical plate, subplate zone, striatum, globus pallidus, thalamus and subthalamus
Sequence caution: Sequence=BAB67803.1; Type=Erroneous initiation;
Secondary accessions: Q5U5I6 Q96SF9

Explore the universe of human proteins at neXtProt for SLITRK1: NX_Q96PX8

Explore proteomics data for SLITRK1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96PX8

    • SLITRK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLITRK1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001268432.1  NP_443142.1  

    ENSEMBL proteins: 
     ENSP00000366288  

    Human Recombinant Protein Products for SLITRK1: 
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
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    Novus Biologicals SLITRK1 Proteins
    Sino Biological Recombinant Protein for SLITRK1
    Sino Biological Cell Lysate for SLITRK1 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLITRK1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    SLITRK1 for ontologies           About GeneDecksing



    SLITRK1 Antibody Products: 
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    Novus Biologicals SLITRK1 Antibodies
    Abcam antibodies for SLITRK1
    Cloud-Clone Corp. Antibodies for SLITRK1 
    ThermoFisher Antibody for SLITRK1
    LSBio Antibodies in human, mouse, rat for SLITRK1 

    Assay Products for SLITRK1: 
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    Cloud-Clone Corp. ELISAs for SLITRK1 
    Cloud-Clone Corp. CLIAs for SLITRK1

    Protein Domains /
    Families
    for SLITRK1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 4 InterPro protein domains:
     IPR000483 Cys-rich_flank_reg_C
     IPR000372 LRR-contain_N
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp

    Graphical View of Domain Structure for InterPro Entry Q96PX8

    ProtoNet protein and cluster: Q96PX8

    1 Blocks protein domain: IPB001611 Leucine-rich repeat signature

    UniProtKB/Swiss-Prot: SLIK1_HUMAN, Q96PX8
    Similarity: Belongs to the SLITRK family
    Similarity: Contains 12 LRR (leucine-rich) repeats
    Similarity: Contains 2 LRRCT domains
    Similarity: Contains 2 LRRNT domains


    SLITRK1 for domains           About GeneDecksing


    Function
    for SLITRK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLIK1_HUMAN, Q96PX8
    Function: Enhances neuronal dendrite outgrowth

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SLITRK1 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Slitrk1):
     behavior/neurological  growth/size  homeostasis/metabolism  mortality/aging  nervous system 

    SLITRK1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for SLITRK1: Slitrk1tm1Lex Slitrk1tm1Jaru
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLITRK1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLITRK1

    miRNA
    Products:            		miRTarBase miRNAs that target SLITRK1:
    hsa-mir-24-1 (MIRT005653)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLITRK1
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate SLITRK1 (see all 35):
    hsa-miR-4291 hsa-miR-429 hsa-miR-517a hsa-miR-517c hsa-miR-4275 hsa-miR-570 hsa-miR-532-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmid: SLITRK1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLITRK1
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    Sirion Biotech Custom design and validation of potent shRNA sequences against SLITRK1

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SLITRK1
                         Customized adenovirus for potent knockdown of SLITRK1

    Clone
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    OriGene ORF clones in mouse, rat for SLITRK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLITRK1 (NM_052910)
    Sino Biological Human cDNA Clone for SLITRK1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLITRK1

    Cell Line
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                         Customized inducible knockdown cell line services for SLITRK1
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLITRK1


    Pathways & Interactions
    for SLITRK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLITRK1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLITRK1 (Q96PX82, 3 ENSP000003662884) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319462, 3, ENSP000003001614MINT-8009119 I2D: score=1 STRING: ENSP00000300161
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development ----
    GO:0007409axonogenesis IEA--
    GO:0030534adult behavior IEA--
    GO:0035264multicellular organism growth IEA--
    GO:0042592homeostatic process IEA--

    SLITRK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLITRK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLITRK1 (SLIK1)

    Search CenterWatch for drugs/clinical trials and news about SLITRK1 / SLIK1

    Transcripts
    for SLITRK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLITRK1 gene (2 alternative transcripts): 
    NM_001281503.1  NM_052910.2  

    Unigene Cluster for SLITRK1:

    SLIT and NTRK-like family, member 1
    Hs.415478  [show with all ESTs]
    Unigene Representative Sequence: NM_052910
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377084(uc001vlk.3)
    miRNA
    Products:         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLITRK1
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate SLITRK1 (see all 35):
    hsa-miR-4291 hsa-miR-429 hsa-miR-517a hsa-miR-517c hsa-miR-4275 hsa-miR-570 hsa-miR-532-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmid: SLITRK1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SLITRK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLITRK1
    Sirion Biotech Custom design and validation of potent shRNA sequences against SLITRK1
    Clone
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    GenScript: all cDNA clones in your preferred vector: SLITRK1 (NM_052910)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLITRK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLITRK1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SLITRK1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLITRK1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLITRK1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLITRK1

    Additional mRNA sequence: 

    AB067497.1 AK299479.1 AY358289.1 BC051738.1 

    1 DOTS entry:

    DT.91649135 

    24/26 AceView cDNA sequences (see all 26):

    AB067497 NM_052910 AY358289 BC051738 T31600 BX496202 Z40879 F10062 
    AA677641 BF439516 Z45152 BF932057 H08054 BX091443 F12440 AI500170 
    BI546610 AI565671 AW962553 Z42346 T73996 R35384 T82468 R49685 

    GeneLoc Exon Structure


    Expression
    for SLITRK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLITRK1 expression in normal human tissues (normalized intensities)      SLITRK1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCAATTAAT
    SLITRK1 Expression
    About this image


    SLITRK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced SK11 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced SM30 cells
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             bronchus ; respiratory epithelial cells
     
     Reproductive System (Reproductive System)
             fallopian tube ; glandular cells

    See SLITRK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLITRK1

    SOURCE GeneReport for Unigene cluster: Hs.415478

    UniProtKB/Swiss-Prot: SLIK1_HUMAN, Q96PX8
    Tissue specificity: Expressed predominantly in the frontal lobe of the cerebral cortex of the brain. Also expressed in
    some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive
    neuroectodermal tumors

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    In Situ
    Assay Products:     
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    Orthologs
    for SLITRK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SLITRK1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Slitrk11 , 5 SLIT and NTRK-like family, member 11, 5 92.91(n)1
    97.56(a)1    		   14 (56.78 cM)5
    769651  NM_199065.21  NP_951020.11 
     1089099915 
    chicken
    (Gallus gallus)    		 Aves SLITRK11 SLIT and NTRK-like family, member 1 81.36(n)
    89.31(a)    		   418798  XM_416993.3  XP_416993.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SLITRK16
    		 Uncharacterized protein
    		 85(a)
    		 1 ↔ 1
    		 3(93916936-93919041)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5587431 SLIT and NTRK-like protein 1-like 69(n)
    72.59(a)    		   558743  XM_682001.4  XP_687093.2 


    ENSEMBL Gene Tree for SLITRK1 (if available)
    TreeFam Gene Tree for SLITRK1 (if available)

    Paralogs
    for SLITRK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLITRK1 gene
    SLITRK22  SLITRK52  ELFN12  ELFN22  SLITRK62  LRRC192  SLITRK32  SLITRK42  
    6 SIMAP similar genes for SLITRK1 using alignment to 1 protein entry:     SLIK1_HUMAN:
    DKFZp451E1911    SLITRK2    SLITRK4    SLITRK3    SLITRK5    SLITRK6

    SLITRK1 for paralogs           About GeneDecksing



    Genomic Variants
    for SLITRK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/166 SNPs in SLITRK1 are shown (see all 166)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1912844031,2
    		Cpathogenic165351172(+) CCTACC/TGATCA 1 -- ut310--------
    rs1860011001,2
    		--65349212(+) TTTTCA/CATTAA 1 -- ds50010--------
    rs170774051,2
    		C,F,H--65349254(+) CTTCTA/GTGAGA 1 -- ds500110Minor allele frequency- G:0.06NA NS CSA WA 1052
    rs1889007731,2
    		--65349335(+) TGCCAA/TTAAAT 1 -- ds50010--------
    rs415617121,2
    		C,F--65349344(-) GAAGGT/CGACAT 1 -- ds50016Minor allele frequency- C:0.20EU NA EA 426
    rs1485831481,2
    		--65349395(+) CTTTCC/TAAAGG 1 -- ds50010--------
    rs1455900891,2
    		--65349487(+) AGTTGC/TACTTT 1 -- ds50010--------
    rs1477134521,2
    		--65349630(+) AATGAC/TGAATG 1 -- ds50010--------
    rs1820276441,2
    		--65349774(+) CTTACA/GACTGC 1 -- ut310--------
    rs1860690291,2
    		C--65349786(+) CTGAGA/GTCTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SLITRK1 (84451343 - 84456528 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLITRK1: --

    Human Gene Mutation Database (HGMD): SLITRK1
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLITRK1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLITRK1

    Disorders / Diseases
    for SLITRK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLITRK1 for disorders           About GeneDecksing

    OMIM gene information: 609678   
    OMIM disorders: 137580  613229  
    UniProtKB/Swiss-Prot: SLIK1_HUMAN, Q96PX8
  • Gilles de la Tourette syndrome (GTS) [MIM:137580]: Neurologic disorder manifested particularly by motor and
    • vocal tics and associated with behavioral abnormalities. Note=The disease may be caused by mutations affecting the
    gene represented in this entry
  • Trichotillomania (TTM) [MIM:613229]: A neuropsychiatric disorder characterized by chronic, repetitive, or
    • compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and
    often have overlapping psychological disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive
    disorder. Note=The disease may be caused by mutations affecting the gene represented in this entry

    17 diseases for SLITRK1:    About MalaCards
    tourette disorder    trichotillomania    body dysmorphic disorder    neurotic excoriation
    stereotypic movement disorder    gilles de la tourette syndrome    hair loss    wilson disease
    obsessive-compulsive disorder    ganglioglioma    primitive neuroectodermal tumor    myotonic dystrophy
    oligodendroglioma    astrocytoma    glioblastoma    cerebritis
    neuronitis

    7 diseases from the University of Copenhagen DISEASES database for SLITRK1:
    Trichotillomania     Gilles de la Tourette syndrome     Stereotypic movement disorder     Wilson disease
    Body dysmorphic disorder     Neurotic excoriation     Kleptomania
    Genetic Association Database (GAD): SLITRK1
    Human Genome Epidemiology (HuGE) Navigator: SLITRK1 (7 documents)

    Export disorders for SLITRK1 gene to outside databases

    Publications
    for SLITRK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLITRK1 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with SLITRK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. (PubMed id 14557068)1, 2, 3, 9 Aruga J.... Mikoshiba K. (2003)
    2. Sequence variants in SLITRK1 are associated with Tourette's syndrome. (PubMed id 16224024)1, 2, 4 Abelson J.F.... State M.W. (2005)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
    4. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    5. Association study between Gilles de la Tourette Syndrome and two genes in the Robo-Slit pathway located in the chromosome 11q24 linked/associated region. (PubMed id 17671968)1, 4 Miranda D.M....Barr C.L. (2008)
    6. Sequence analysis of the complete SLITRK1 gene in Austrian patients with Tourette's disorder. (PubMed id 19018236)1, 4 Zimprich A....Stamenkovic M. (2008)
    7. Examination of the SLITRK1 gene in Caucasian patients with Tourette syndrome. (PubMed id 17083340)1, 4 Deng H....Jankovic J. (2006)
    8. Overrepresentation of rare variants in a specific ethnic group may confuse interpretation of association analyses. (PubMed id 17035247)1, 4 Keen-Kim D....Freimer N.B. (2006)
    9. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for SLITRK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing SLITRK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 114798 HGNC: 20297 AceView: SLITRK1 Ensembl:ENSG00000178235 euGenes: HUgn114798
    ECgene: SLITRK1 H-InvDB: SLITRK1

    Other Databases showing SLITRK1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1910

    Specialized Databases showing SLITRK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLITRK1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLITRK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLITRK1 gene:
    Search GeneIP for patents involving SLITRK1

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