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SLITRK1 Gene

protein-coding   GIFtS: 58
GCID: GC13M084451

SLIT And NTRK-Like Family, Member 1

(Previous name: leucine rich repeat containing 12)
(Previous symbol: LRRC12)
  See SLITRK1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SLIT And NTRK-Like Family, Member 11 2     KIAA19103 5
LRRC121 2 3     Leucine Rich Repeat Containing 121
Leucine-Rich Repeat-Containing Protein 122 3     SLIT And NTRK-Like Protein 12
TTM2 5     Slit And Trk Like Gene 12

External Ids:    HGNC: 202971   Entrez Gene: 1147982   Ensembl: ENSG000001782357   OMIM: 6096785   UniProtKB: Q96PX83   

Export aliases for SLITRK1 gene to outside databases

Previous GC identifers: GC13M082251 GC13M082249 GC13M083349 GC13M065151


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLITRK1 Gene:
This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins
that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares
homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology
to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene
may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. (provided
by RefSeq, Jul 2013)

GeneCards Summary for SLITRK1 Gene:
SLITRK1 (SLIT and NTRK-like family, member 1) is a protein-coding gene. Diseases associated with SLITRK1 include trichotillomania, and kleptomania. An important paralog of this gene is SLITRK5.

UniProtKB/Swiss-Prot: SLIK1_HUMAN, Q96PX8
Function: Enhances neuronal dendrite outgrowth

Gene Wiki entry for SLITRK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLITRK1 gene promoter:
         STAT1   STAT1beta   Nkx2-5   CUTL1   STAT1alpha   SRY   POU2F1   POU2F1a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLITRK1 promoter sequence
   Search Chromatin IP Primers for SLITRK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLITRK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q31.1   Ensembl cytogenetic band:  13q31.1   HGNC cytogenetic band: 13q31.1

SLITRK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLITRK1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M084451:  view genomic region     (about GC identifiers)

Start:
84,451,343 bp from pter      End:
84,456,528 bp from pter
Size:
5,186 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SLIK1_HUMAN, Q96PX8 (See protein sequence)
Recommended Name: SLIT and NTRK-like protein 1 precursor  
Size: 696 amino acids; 77735 Da
Developmental stage: At 20 weeks of gestation, expressed in multiple brain regions, including the developing
neo-cortical plate, subplate zone, striatum, globus pallidus, thalamus and subthalamus
Sequence caution: Sequence=BAB67803.1; Type=Erroneous initiation;
Secondary accessions: Q5U5I6 Q96SF9

Explore the universe of human proteins at neXtProt for SLITRK1: NX_Q96PX8

Explore proteomics data for SLITRK1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLITRK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001268432.1  NP_443142.1  

    ENSEMBL proteins: 
     ENSP00000366288  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry Q96PX8

    ProtoNet protein and cluster: Q96PX8

    1 Blocks protein domain: IPB001611 Leucine-rich repeat signature

    UniProtKB/Swiss-Prot: SLIK1_HUMAN, Q96PX8
    Similarity: Belongs to the SLITRK family
    Similarity: Contains 12 LRR (leucine-rich) repeats
    Similarity: Contains 2 LRRCT domains
    Similarity: Contains 2 LRRNT domains


    Find genes that share domains with SLITRK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLIK1_HUMAN, Q96PX8
    Function: Enhances neuronal dendrite outgrowth

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SLITRK1           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slitrk1):
     behavior/neurological  growth/size/body  homeostasis/metabolism  mortality/aging  nervous system 

    Find genes that share phenotypes with SLITRK1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SLITRK1: Slitrk1tm1Lex Slitrk1tm1Jaru

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLITRK1
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    miRTarBase miRNAs that target SLITRK1:
    hsa-mir-24-1-5p (MIRT005653), hsa-mir-335-5p (MIRT018680)

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    Selected qRT-PCR Assays for microRNAs that regulate SLITRK1 (see all 35):
    hsa-miR-4291 hsa-miR-429 hsa-miR-517a hsa-miR-517c hsa-miR-4275 hsa-miR-570 hsa-miR-532-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidSLITRK1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SLIK1_HUMAN, Q96PX8: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLITRK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLITRK1
    Interactions:

        Search GeneGlobe Interaction Network for SLITRK1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLITRK1 (Q96PX82, 3 ENSP000003662884) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319462, 3, ENSP000003001614MINT-8009119 I2D: score=1 STRING: ENSP00000300161
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development ----
    GO:0007409axonogenesis IEA--
    GO:0030534adult behavior IEA--
    GO:0035264multicellular organism growth IEA--
    GO:0042592homeostatic process IEA--

    Find genes that share ontologies with SLITRK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLITRK1 (SLIK1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLITRK1 gene (2 alternative transcripts): 
    NM_001281503.1  NM_052910.2  

    Unigene Cluster for SLITRK1:

    SLIT and NTRK-like family, member 1
    Hs.415478  [show with all ESTs]
    Unigene Representative Sequence: NM_052910
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377084(uc001vlk.3)
    miRNA
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    hsa-miR-4291 hsa-miR-429 hsa-miR-517a hsa-miR-517c hsa-miR-4275 hsa-miR-570 hsa-miR-532-5p hsa-miR-3148
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      QuantiTect SYBR Green Assays in human, mouse, rat SLITRK1
      QuantiFast Probe-based Assays in human, mouse, rat SLITRK1

    Additional mRNA sequence: 

    AB067497.1 AK299479.1 AY358289.1 BC051738.1 

    1 DOTS entry:

    DT.91649135 

    Selected AceView cDNA sequences (see all 26):

    NM_052910 BC051738 AY358289 AB067497 Z45152 T31600 F10062 Z40879 
    BF439516 AA677641 BX496202 H08054 BX091443 BF932057 AI500170 F12440 
    AI565671 AW962553 BI546610 T82468 Z42346 R35384 T73996 H08053 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLITRK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCAATTAAT
    SLITRK1 Expression
    About this image


    SLITRK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced SK11 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced SM30 cells
     
     Ovary (Reproductive System)
             Oviduct
     
     Adipose (Muscoskeletal System)
             HyStem+BMP4-induced SM30 cells
    SLITRK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLITRK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.415478

    UniProtKB/Swiss-Prot: SLIK1_HUMAN, Q96PX8
    Tissue specificity: Expressed predominantly in the frontal lobe of the cerebral cortex of the brain. Also
    expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas
    and primitive neuroectodermal tumors

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLITRK1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slitrk11 , 5 SLIT and NTRK-like family, member 11, 5 92.91(n)1
    97.56(a)1
      14 (56.78 cM)5
    769651  NM_199065.21  NP_951020.11 
     1089099915 
    chicken
    (Gallus gallus)
    Aves SLITRK11 SLIT and NTRK-like family, member 1 81.36(n)
    89.31(a)
      418798  XM_416993.4  XP_416993.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLITRK16
    SLIT and NTRK-like family, member 1
    85(a)
    1 ↔ 1
    3(93916936-93919041)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slitrk11 SLIT and NTRK-like family, member 1 74.92(n)
    83.88(a)
      100124997  NM_001102925.1  NP_001096395.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5587431 SLIT and NTRK-like protein 1-like 69(n)
    72.59(a)
      558743  XM_005174629.1  XP_005174686.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sli6
    slit
    10(a)
    1 → many
    2R(11757559-11809623)
    worm
    (Caenorhabditis elegans)
    Secernentea slt-16
    Protein SLT-1 (slt-1) mRNA, complete cds
    10(a)
    1 → many
    X(14674319-14683326) WBGene00004854


    ENSEMBL Gene Tree for SLITRK1 (if available)
    TreeFam Gene Tree for SLITRK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLITRK1 gene
    SLITRK52  ISLR2  SLIT12  SLIT32  SLITRK62  LRRC382  SLIT22  LRRC262  
    SLITRK42  LRTM12  LRRC522  LRRC172  SLITRK22  LRTM22  SLITRK32  LRRC552  
    ISLR22  LRRC242  
    6 SIMAP similar genes for SLITRK1 using alignment to 1 protein entry:     SLIK1_HUMAN:
    DKFZp451E1911    SLITRK2    SLITRK4    SLITRK3    SLITRK5    SLITRK6

    Find genes that share paralogs with SLITRK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLITRK1 (see all 166)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1912844031,2
    Cpathogenic165351172(+) CCTACC/TGATCA 1 -- ut310--------
    rs1860011001,2
    --65349212(+) TTTTCA/CATTAA 1 -- ds50010--------
    rs170774051,2
    C,F,H--65349254(+) CTTCTA/GTGAGA 1 -- ds500110Minor allele frequency- G:0.06NA NS CSA WA 1052
    rs1889007731,2
    --65349335(+) TGCCAA/TTAAAT 1 -- ds50010--------
    rs415617121,2
    C,F--65349344(-) GAAGGT/CGACAT 1 -- ds50016Minor allele frequency- C:0.20EU NA EA 426
    rs1485831481,2
    --65349395(+) CTTTCC/TAAAGG 1 -- ds50010--------
    rs1455900891,2
    --65349487(+) AGTTGC/TACTTT 1 -- ds50010--------
    rs1477134521,2
    --65349630(+) AATGAC/TGAATG 1 -- ds50010--------
    rs1820276441,2
    --65349774(+) CTTACA/GACTGC 1 -- ut310--------
    rs1860690291,2
    C--65349786(+) CTGAGA/GTCTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SLITRK1 (84451343 - 84456528 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLITRK1: --
    Human Gene Mutation Database (HGMD): SLITRK1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLITRK1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLITRK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609678   
    OMIM disorders: 137580  613229  
    UniProtKB/Swiss-Prot: SLIK1_HUMAN, Q96PX8
  • Gilles de la Tourette syndrome (GTS) [MIM:137580]: Neurologic disorder manifested particularly by motor
    and vocal tics and associated with behavioral abnormalities. Note=The disease may be caused by mutations
    affecting the gene represented in this entry
  • Trichotillomania (TTM) [MIM:613229]: A neuropsychiatric disorder characterized by chronic, repetitive, or
    compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical
    complications and often have overlapping psychological disorders, such as Gilles de la Tourette syndrome or
    obsessive-compulsive disorder. Note=The disease may be caused by mutations affecting the gene represented in this
    entry

  • 6 diseases for SLITRK1:    
    About MalaCards
    trichotillomania    kleptomania    body dysmorphic disorder    neurotic excoriation
    stereotypic movement disorder    gilles de la tourette syndrome

    7 diseases from the University of Copenhagen DISEASES database for SLITRK1:
    Trichotillomania     Gilles de la Tourette syndrome     Stereotypic movement disorder     Wilson disease
    Body dysmorphic disorder     Neurotic excoriation     Kleptomania

    Find genes that share disorders with SLITRK1           About GenesLikeMe

    Genetic Association Database (GAD): SLITRK1
    Human Genome Epidemiology (HuGE) Navigator: SLITRK1 (7 documents)

    Export disorders for SLITRK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLITRK1 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with SLITRK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. (PubMed id 14557068)1, 2, 3, 9 Aruga J.... Mikoshiba K. (Gene 2003)
    2. Sequence variants in SLITRK1 are associated with Tourette's syndrome. (PubMed id 16224024)1, 2, 4 Abelson J.F.... State M.W. (Science 2005)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    5. Association study between Gilles de la Tourette Syndrome and two genes in the Robo-Slit pathway located in the chromosome 11q24 linked/associated region. (PubMed id 17671968)1, 4 Miranda D.M....Barr C.L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    6. Sequence analysis of the complete SLITRK1 gene in Austrian patients with Tourette's disorder. (PubMed id 19018236)1, 4 Zimprich A....Stamenkovic M. (Psychiatr. Genet. 2008)
    7. Examination of the SLITRK1 gene in Caucasian patients with Tourette syndrome. (PubMed id 17083340)1, 4 Deng H....Jankovic J. (Acta Neurol. Scand. 2006)
    8. Overrepresentation of rare variants in a specific ethnic group may confuse interpretation of association analyses. (PubMed id 17035247)1, 4 Keen-Kim D....Freimer N.B. (Hum. Mol. Genet. 2006)
    9. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114798 HGNC: 20297 AceView: SLITRK1 Ensembl:ENSG00000178235 euGenes: HUgn114798
    ECgene: SLITRK1 H-InvDB: SLITRK1

    (According to HUGE)
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    HUGE: KIAA1910

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLITRK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLITRK1 gene:
    Search GeneIP for patents involving SLITRK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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