Aliases for SLITRK1 Gene
External Ids for SLITRK1 Gene
Previous HGNC Symbols for SLITRK1 Gene
Previous GeneCards Identifiers for SLITRK1 Gene
This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for SLITRK1 Gene
SLITRK1 (SLIT And NTRK Like Family Member 1) is a Protein Coding gene. Diseases associated with SLITRK1 include Gilles De La Tourette Syndrome and Trichotillomania. An important paralog of this gene is SLITRK2.
UniProtKB/Swiss-Prot for SLITRK1 Gene
It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321). Enhances neuronal dendrite outgrowth (PubMed:16224024, PubMed:19640509).