Aliases for SLITRK1 Gene
Aliases for SLITRK1 Gene
External Ids for SLITRK1 Gene
- HGNC: 20297
- Entrez Gene: 114798
- Ensembl: ENSG00000178235
- OMIM: 609678
- UniProtKB: Q96PX8
Previous HGNC Symbols for SLITRK1 Gene
- LRRC12
Previous GeneCards Identifiers for SLITRK1 Gene
- GC13M082251
- GC13M082249
- GC13M083349
- GC13M084451
- GC13M065151
Summaries for SLITRK1 Gene
-
This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for SLITRK1 Gene
SLITRK1 (SLIT And NTRK Like Family Member 1) is a Protein Coding gene. Diseases associated with SLITRK1 include Gilles De La Tourette Syndrome and Trichotillomania. An important paralog of this gene is SLITRK2.
UniProtKB/Swiss-Prot for SLITRK1 Gene
-
Enhances neuronal dendrite outgrowth.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLITRK1 Gene
Genomics for SLITRK1 Gene
Regulatory Elements for SLITRK1 Gene
Enhancers for SLITRK1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH13F083100 | 0.8 | ENCODE | 8.9 | +780.7 | 780653 | 1.9 | BCOR TBP ATF1 CHAMP1 POLR2A NCOR1 CREM CHD2 SMARCA5 SMARCE1 | SLITRK1 GC13M083079 ENSG00000270400 |
| GH13F083221 | 0.5 | ENCODE | 5.9 | +660.4 | 660364 | 1.6 | JUND NFE2 MAFK NFE2L2 | SLITRK1 GC13P083229 GC13P083166 |
| GH13F083881 | 0.7 | ENCODE | 0.8 | +0.3 | 293 | 1.1 | CBX2 MIER2 REST SMARCA4 POLR2A CTBP2 ZNF143 KDM1A NFE2 FOXP2 | SLITRK1 LOC105370286 |
| GH13F083883 | 0.5 | ENCODE | 0.8 | -0.7 | -708 | 0.1 | PKNOX1 CTBP1 L3MBTL2 | SLITRK1 VENTXP2 |
| GH13F083906 | 0.4 | FANTOM5 | 0.3 | -24.2 | -24175 | 0.1 | VENTXP2 SLITRK1 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around SLITRK1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SLITRK1 gene promoter:
Regulatory Element Products
Genomic Location for SLITRK1 Gene
- Chromosome:
- 13
- Start:
- 83,877,205 bp from pter
- End:
- 83,882,393 bp from pter
- Size:
- 5,189 bases
- Orientation:
- Minus strand
Genomic View for SLITRK1 Gene
Genes around SLITRK1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q31.1 by Ensembl
- 13q31.1 by Entrez Gene
- 13q31.1 by HGNC
SLITRK1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLITRK1 Gene
Proteins for SLITRK1 Gene
-
Protein details for SLITRK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96PX8-SLIK1_HUMAN
- Recommended name:
- SLIT and NTRK-like protein 1
- Protein Accession:
- Q96PX8
- Q5U5I6
- Q96SF9
Protein attributes for SLITRK1 Gene
- Size:
- 696 amino acids
- Molecular mass:
- 77735 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB67803.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for SLITRK1 Gene
Post-translational modifications for SLITRK1 Gene
Other Protein References for SLITRK1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for SLITRK1
- R&D Systems Antibodies for SLITRK1 (SLITRK1)
- Novus Biologicals Antibodies for SLITRK1
- Invitrogen Antibodies for SLITRK1
- antibodies-online Antibodies for SLITRK1: See all 63
- GeneTex Ccl20 antibody for SLITRK1
- GeneTex SLITRK1 antibody for SLITRK1
-
Custom Antibody ServicesProSci Antibodies for SLITRK1
Protein Products
- R&D Systems Proteins and Enzymes for SLITRK1
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- Sino Biological Cell Lysates for SLITRK1
- antibodies-online Proteins for SLITRK1: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for SLITRK1
Assay Products
No data available for DME Specific Peptides for SLITRK1 Gene
Domains & Families for SLITRK1 Gene
Protein Domains for SLITRK1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLITRK1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96PX8UniProtKB/Swiss-Prot:
SLIK1_HUMAN :- Contains 2 LRRCT domains.
- Belongs to the SLITRK family.
- Contains 12 LRR (leucine-rich) repeats.
- Domain:
-
- Contains 2 LRRCT domains.
- Contains 2 LRRNT domains.
- Family:
-
- Belongs to the SLITRK family.
- Similarity:
-
- Contains 12 LRR (leucine-rich) repeats.
No data available for Gene Families for SLITRK1 Gene
Function for SLITRK1 Gene
Molecular function for SLITRK1 Gene
- UniProtKB/Swiss-Prot Function:
- Enhances neuronal dendrite outgrowth.
Phenotypes for SLITRK1 Gene
- MGI mutant phenotypes for SLITRK1:
- inferred from 2 alleles
Animal Model Products
-
Taconic Biosciences Mouse Models for SLITRK1
- Cyagen custom Knockout/knockin (KOKI) mouse models for SLITRK1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SLITRK1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SLITRK1 gene
- Search ViGene Biosciences for SLITRK1
CRISPR Products
-
OriGene CRISPR knockouts for SLITRK1
- GenScript: Design CRISPR guide RNA sequences for SLITRK1
miRNA for SLITRK1 Gene
- miRTarBase miRNAs that target SLITRK1
miRNA Products
- Search ViGene Biosciences for SLITRK1
Clone Products
- Sino Biological Human cDNA Clone for SLITRK1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SLITRK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLITRK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for SLITRK1
Cell Line Products
-
Horizon Cell Lines for SLITRK1
-
ViGene Biosciences adenoviral particle packaged cDNA for SLITRK1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SLITRK1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SLITRK1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for SLITRK1 Gene
Localization for SLITRK1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLITRK1 Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| plasma membrane | 3 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for SLITRK1 Gene
No Data Available
Interacting Proteins for SLITRK1 Gene
Selected Interacting proteins:
Q96PX8-SLIK1_HUMAN
ENSP00000366288
for SLITRK1 Gene via
IID
STRING
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007409 | axonogenesis | IEA,IBA | -- |
| GO:0030534 | adult behavior | IEA | -- |
| GO:0035264 | multicellular organism growth | IEA | -- |
| GO:0042592 | homeostatic process | IEA | -- |
| GO:0051965 | positive regulation of synapse assembly | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SLITRK1 Gene
Transcripts for SLITRK1 Gene
mRNA/cDNA for SLITRK1 Gene
- (2) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (26) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SLITRK1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SLITRK1
- GenScript: Design CRISPR guide RNA sequences for SLITRK1
miRNA Products
- Search ViGene Biosciences for SLITRK1
Clone Products
- Sino Biological Human cDNA Clone for SLITRK1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SLITRK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLITRK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for SLITRK1
Flow Cytometry Products
Expression for SLITRK1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for SLITRK1 Gene
This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.8), Brain - Anterior cingulate cortex (BA24) (x7.8), Brain - Cortex (x7.5), Brain - Hippocampus (x5.0), and Brain - Amygdala (x4.9).
This gene is overexpressed in Cerebrospinal fluid (32.2), Serum (12.7), Lung (11.9), and Kidney (8.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLITRK1 Gene
NURSA nuclear receptor signaling pathways regulating expression of SLITRK1 Gene:
SLITRK1SOURCE GeneReport for Unigene cluster for SLITRK1 Gene:
Hs.415478mRNA Expression by UniProt/SwissProt for SLITRK1 Gene:
Q96PX8-SLIK1_HUMAN
Tissue specificity:
Expressed predominantly in the frontal lobe of the cerebral cortex of the brain. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors.
Primer Products
-
OriGene qPCR primer pairs for SLITRK1
-
OriGene qPCR primer pairs and template standards for SLITRK1
No data available for Protein tissue co-expression partners for SLITRK1 Gene
Orthologs for SLITRK1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SLITRK1 35 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SLITRK1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | SLITRK1 35 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Slitrk1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Slitrk1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SLITRK1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| chicken (Gallus gallus) |
Aves | SLITRK1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | SLITRK1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | slitrk1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | SLITRK1 35 |
|
OneToOne | |
| LOC558743 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | sli 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | slt-1 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for SLITRK1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SLITRK1 Gene
Variants for SLITRK1 Gene
| SNP ID | Clin | Chr 13 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs191284403 | Pathogenic | 83,878,728(+) | CCTAC(C/T)GATCA | utr-variant-3-prime | |
| rs193302861 | Pathogenic | 83,880,244(-) | AGAAC(-/C)TTTTG | reference, frameshift-variant | |
| rs1046202 | -- | 83,877,375(-) | TTTTT(A/T)TAATA | utr-variant-3-prime | |
| rs112387553 | -- | 83,883,214(+) | CACTA(C/G)ACGCA | upstream-variant-2KB | |
| rs117206130 | -- | 83,877,454(+) | AATAT(A/G)TGTGG | utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1040716 | CNV | gain | 25217958 |
| nsv562552 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.22;
24.41% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SLITRK1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLITRK1 Gene
Disorders for SLITRK1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gilles de la tourette syndrome |
|
|
| trichotillomania |
|
|
| obsessive-compulsive disorder |
|
|
| body dysmorphic disorder |
|
|
| neurotic excoriation |
|
|
Search SLITRK1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
SLIK1_HUMAN- Trichotillomania (TTM) [MIM:613229]: A neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychological disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder. {ECO:0000269 PubMed:16224024}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
Relevant External Links for SLITRK1
No data available for Genatlas for SLITRK1 Gene
Publications for SLITRK1 Gene
- Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. (PMID: 14557068) Aruga J. … Mikoshiba K. (Gene 2003) 2 3 4 22 64
- Sequence variants in SLITRK1 are associated with Tourette's syndrome. (PMID: 16224024) Abelson J.F. … State M.W. (Science 2005) 3 4 46 64
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
- Association study between Gilles de la Tourette Syndrome and two genes in the Robo-Slit pathway located in the chromosome 11q24 linked/associated region. (PMID: 17671968) Miranda D.M. … Barr C.L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 46 64
Products for SLITRK1 Gene
- R&D Systems Antibodies for SLITRK1 (SLITRK1)
- R&D Systems Proteins and Enzymes for SLITRK1
- Browse R&D Systems for biochemical assays
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- Browse Primary Antibodies
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- OriGene qPCR primer pairs and template standards for SLITRK1
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- Taconic Biosciences Mouse Models for SLITRK1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- antibodies-online Antibodies for SLITRK1: See all 63
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- antibodies-online Proteins for SLITRK1: See all 4
- Search antibodies-online for peptides
- GeneTex Ccl20 antibody for SLITRK1
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- Search GeneTex for Proteins for SLITRK1
- ViGene Biosciences adenoviral particle packaged cDNA for SLITRK1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SLITRK1 gene
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- Search ViGene Biosciences for SLITRK1
- Custom Antibody ServicesProSci Antibodies for SLITRK1
- Horizon Cell Lines for SLITRK1
- Cyagen custom Knockout/knockin (KOKI) mouse models for SLITRK1
- VectorBuilder custom plasmid, inducible vectors for SLITRK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLITRK1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for SLITRK1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
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- (62) NCBI
- (63) OriGene
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- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
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- (80) neXtProt
- (81) Reactome
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- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab