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Aliases for SLITRK1 Gene

Aliases for SLITRK1 Gene

  • SLIT And NTRK Like Family Member 1 2 3 5
  • Leucine-Rich Repeat-Containing Protein 12 3 4
  • LRRC12 3 4
  • SLIT And NTRK-Like Family, Member 1 2
  • Leucine Rich Repeat Containing 12 2
  • SLIT And NTRK-Like Protein 1 3
  • Slit And Trk Like Gene 1 3
  • KIAA1910 4
  • TTM 3

External Ids for SLITRK1 Gene

Previous HGNC Symbols for SLITRK1 Gene

  • LRRC12

Previous GeneCards Identifiers for SLITRK1 Gene

  • GC13M082251
  • GC13M082249
  • GC13M083349
  • GC13M084451
  • GC13M065151

Summaries for SLITRK1 Gene

Entrez Gene Summary for SLITRK1 Gene

  • This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for SLITRK1 Gene

SLITRK1 (SLIT And NTRK Like Family Member 1) is a Protein Coding gene. Diseases associated with SLITRK1 include Gilles De La Tourette Syndrome and Trichotillomania. An important paralog of this gene is SLITRK2.

UniProtKB/Swiss-Prot for SLITRK1 Gene

  • Enhances neuronal dendrite outgrowth.

Gene Wiki entry for SLITRK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLITRK1 Gene

Genomics for SLITRK1 Gene

Regulatory Elements for SLITRK1 Gene

Enhancers for SLITRK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F083100 0.8 ENCODE 8.9 +780.7 780653 1.9 BCOR TBP ATF1 CHAMP1 POLR2A NCOR1 CREM CHD2 SMARCA5 SMARCE1 SLITRK1 GC13M083079 ENSG00000270400
GH13F083221 0.5 ENCODE 5.9 +660.4 660364 1.6 JUND NFE2 MAFK NFE2L2 SLITRK1 GC13P083229 GC13P083166
GH13F083881 0.7 ENCODE 0.8 +0.3 293 1.1 CBX2 MIER2 REST SMARCA4 POLR2A CTBP2 ZNF143 KDM1A NFE2 FOXP2 SLITRK1 LOC105370286
GH13F083883 0.5 ENCODE 0.8 -0.7 -708 0.1 PKNOX1 CTBP1 L3MBTL2 SLITRK1 VENTXP2
GH13F083906 0.4 FANTOM5 0.3 -24.2 -24175 0.1 VENTXP2 SLITRK1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLITRK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLITRK1 Gene

83,877,205 bp from pter
83,882,393 bp from pter
5,189 bases
Minus strand

Genomic View for SLITRK1 Gene

Genes around SLITRK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLITRK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLITRK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLITRK1 Gene

Proteins for SLITRK1 Gene

  • Protein details for SLITRK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SLIT and NTRK-like protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5U5I6
    • Q96SF9

    Protein attributes for SLITRK1 Gene

    696 amino acids
    Molecular mass:
    77735 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB67803.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLITRK1 Gene

neXtProt entry for SLITRK1 Gene

Post-translational modifications for SLITRK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLITRK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLITRK1 Gene

Domains & Families for SLITRK1 Gene

Suggested Antigen Peptide Sequences for SLITRK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 LRRCT domains.
  • Belongs to the SLITRK family.
  • Contains 12 LRR (leucine-rich) repeats.
  • Contains 2 LRRCT domains.
  • Contains 2 LRRNT domains.
  • Belongs to the SLITRK family.
  • Contains 12 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with SLITRK1: view

No data available for Gene Families for SLITRK1 Gene

Function for SLITRK1 Gene

Molecular function for SLITRK1 Gene

UniProtKB/Swiss-Prot Function:
Enhances neuronal dendrite outgrowth.
genes like me logo Genes that share phenotypes with SLITRK1: view

Human Phenotype Ontology for SLITRK1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLITRK1 Gene

MGI Knock Outs for SLITRK1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLITRK1

miRNA for SLITRK1 Gene

miRTarBase miRNAs that target SLITRK1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for SLITRK1 Gene

Localization for SLITRK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLITRK1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLITRK1 gene
Compartment Confidence
extracellular 4
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLITRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLITRK1: view

Pathways & Interactions for SLITRK1 Gene

SuperPathways for SLITRK1 Gene

No Data Available

Interacting Proteins for SLITRK1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q96PX8-SLIK1_HUMAN ENSP00000366288 for SLITRK1 Gene via IID STRING MINT

Gene Ontology (GO) - Biological Process for SLITRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007409 axonogenesis IEA,IBA --
GO:0030534 adult behavior IEA --
GO:0035264 multicellular organism growth IEA --
GO:0042592 homeostatic process IEA --
GO:0051965 positive regulation of synapse assembly IEA --
genes like me logo Genes that share ontologies with SLITRK1: view

No data available for Pathways by source and SIGNOR curated interactions for SLITRK1 Gene

Transcripts for SLITRK1 Gene

mRNA/cDNA for SLITRK1 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(26) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLITRK1 Gene

SLIT and NTRK-like family, member 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLITRK1 Gene

No ASD Table

Relevant External Links for SLITRK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLITRK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLITRK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLITRK1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.8), Brain - Anterior cingulate cortex (BA24) (x7.8), Brain - Cortex (x7.5), Brain - Hippocampus (x5.0), and Brain - Amygdala (x4.9).

Protein differential expression in normal tissues from HIPED for SLITRK1 Gene

This gene is overexpressed in Cerebrospinal fluid (32.2), Serum (12.7), Lung (11.9), and Kidney (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLITRK1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLITRK1 Gene:


SOURCE GeneReport for Unigene cluster for SLITRK1 Gene:


mRNA Expression by UniProt/SwissProt for SLITRK1 Gene:

Tissue specificity: Expressed predominantly in the frontal lobe of the cerebral cortex of the brain. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors.
genes like me logo Genes that share expression patterns with SLITRK1: view

Primer Products

No data available for Protein tissue co-expression partners for SLITRK1 Gene

Orthologs for SLITRK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLITRK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLITRK1 35 34
  • 99.81 (n)
(Bos Taurus)
Mammalia SLITRK1 34 35
  • 95.45 (n)
(Canis familiaris)
Mammalia SLITRK1 35 34
  • 94.92 (n)
(Mus musculus)
Mammalia Slitrk1 34 16 35
  • 92.91 (n)
(Rattus norvegicus)
Mammalia Slitrk1 34
  • 92.53 (n)
(Monodelphis domestica)
Mammalia SLITRK1 35
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 2 (a)
-- 35
  • 1 (a)
(Gallus gallus)
Aves SLITRK1 34 35
  • 81.36 (n)
(Anolis carolinensis)
Reptilia SLITRK1 35
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slitrk1 34
  • 74.92 (n)
(Danio rerio)
Actinopterygii SLITRK1 35
  • 71 (a)
LOC558743 34
  • 69 (n)
fruit fly
(Drosophila melanogaster)
Insecta sli 35
  • 10 (a)
(Caenorhabditis elegans)
Secernentea slt-1 35
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 16 (a)
Species where no ortholog for SLITRK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLITRK1 Gene

Gene Tree for SLITRK1 (if available)
Gene Tree for SLITRK1 (if available)

Paralogs for SLITRK1 Gene

Paralogs for SLITRK1 Gene

(6) SIMAP similar genes for SLITRK1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLITRK1: view

Variants for SLITRK1 Gene

Sequence variations from dbSNP and Humsavar for SLITRK1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs191284403 Pathogenic 83,878,728(+) CCTAC(C/T)GATCA utr-variant-3-prime
rs193302861 Pathogenic 83,880,244(-) AGAAC(-/C)TTTTG reference, frameshift-variant
rs1046202 -- 83,877,375(-) TTTTT(A/T)TAATA utr-variant-3-prime
rs112387553 -- 83,883,214(+) CACTA(C/G)ACGCA upstream-variant-2KB
rs117206130 -- 83,877,454(+) AATAT(A/G)TGTGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLITRK1 Gene

Variant ID Type Subtype PubMed ID
nsv1040716 CNV gain 25217958
nsv562552 CNV loss 21841781

Variation tolerance for SLITRK1 Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLITRK1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLITRK1 Gene

Disorders for SLITRK1 Gene

MalaCards: The human disease database

(12) MalaCards diseases for SLITRK1 Gene - From: OMIM, ClinVar, GeneTests, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
gilles de la tourette syndrome
  • tourette syndrome
  • hair-pulling syndrome
obsessive-compulsive disorder
  • obsessive-compulsive disorder, protection against
body dysmorphic disorder
  • body dysmorphia
neurotic excoriation
  • dermatitis artefacta
- elite association - COSMIC cancer census association via MalaCards


  • Trichotillomania (TTM) [MIM:613229]: A neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychological disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder. {ECO:0000269 PubMed:16224024}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLITRK1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLITRK1: view

No data available for Genatlas for SLITRK1 Gene

Publications for SLITRK1 Gene

  1. Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. (PMID: 14557068) Aruga J. … Mikoshiba K. (Gene 2003) 2 3 4 22 64
  2. Sequence variants in SLITRK1 are associated with Tourette's syndrome. (PMID: 16224024) Abelson J.F. … State M.W. (Science 2005) 3 4 46 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  5. Association study between Gilles de la Tourette Syndrome and two genes in the Robo-Slit pathway located in the chromosome 11q24 linked/associated region. (PMID: 17671968) Miranda D.M. … Barr C.L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 46 64

Products for SLITRK1 Gene

Sources for SLITRK1 Gene

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