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Aliases for SLITRK1 Gene

Aliases for SLITRK1 Gene

  • SLIT And NTRK-Like Family, Member 1 2 3
  • Leucine-Rich Repeat-Containing Protein 12 3 4
  • KIAA1910 4 6
  • LRRC12 3 4
  • TTM 3 6
  • Leucine Rich Repeat Containing 12 2
  • SLIT And NTRK-Like Protein 1 3
  • Slit And Trk Like Gene 1 3

External Ids for SLITRK1 Gene

Previous HGNC Symbols for SLITRK1 Gene

  • LRRC12

Previous GeneCards Identifiers for SLITRK1 Gene

  • GC13M082251
  • GC13M082249
  • GC13M083349
  • GC13M084451
  • GC13M065151

Summaries for SLITRK1 Gene

Entrez Gene Summary for SLITRK1 Gene

  • This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for SLITRK1 Gene

SLITRK1 (SLIT And NTRK-Like Family, Member 1) is a Protein Coding gene. Diseases associated with SLITRK1 include trichotillomania and gilles de la tourette syndrome. An important paralog of this gene is SLITRK3.

UniProtKB/Swiss-Prot for SLITRK1 Gene

  • Enhances neuronal dendrite outgrowth.

Gene Wiki entry for SLITRK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLITRK1 Gene

Genomics for SLITRK1 Gene

Regulatory Elements for SLITRK1 Gene

Genomic Location for SLITRK1 Gene

83,877,205 bp from pter
83,882,393 bp from pter
5,189 bases
Minus strand

Genomic View for SLITRK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLITRK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLITRK1 Gene

Proteins for SLITRK1 Gene

  • Protein details for SLITRK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SLIT and NTRK-like protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5U5I6
    • Q96SF9

    Protein attributes for SLITRK1 Gene

    696 amino acids
    Molecular mass:
    77735 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB67803.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLITRK1 Gene

neXtProt entry for SLITRK1 Gene

Proteomics data for SLITRK1 Gene at MOPED

Post-translational modifications for SLITRK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLITRK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLITRK1 Gene

Domains for SLITRK1 Gene

Suggested Antigen Peptide Sequences for SLITRK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96PX8
  • Contains 2 LRRCT domains.
  • Contains 2 LRRNT domains.
  • Belongs to the SLITRK family.
  • Contains 12 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with SLITRK1: view

No data available for Gene Families for SLITRK1 Gene

Function for SLITRK1 Gene

Molecular function for SLITRK1 Gene

UniProtKB/Swiss-Prot Function:
Enhances neuronal dendrite outgrowth.

Gene Ontology (GO) - Molecular Function for SLITRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SLITRK1: view
genes like me logo Genes that share phenotypes with SLITRK1: view

Animal Models for SLITRK1 Gene

MGI Knock Outs for SLITRK1:

Animal Model Products

CRISPR Products

miRNA for SLITRK1 Gene

miRTarBase miRNAs that target SLITRK1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLITRK1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLITRK1 Gene

Localization for SLITRK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLITRK1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SLITRK1 Gene COMPARTMENTS Subcellular localization image for SLITRK1 gene
Compartment Confidence
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLITRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLITRK1: view

Pathways for SLITRK1 Gene

SuperPathways for SLITRK1 Gene

No Data Available

Interacting Proteins for SLITRK1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q96PX8-SLIK1_HUMAN ENSP00000366288 for SLITRK1 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for SLITRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development --
GO:0007409 axonogenesis IEA --
GO:0030534 adult behavior IEA --
GO:0035264 multicellular organism growth IEA --
GO:0042592 homeostatic process IEA --
genes like me logo Genes that share ontologies with SLITRK1: view

No data available for Pathways by source for SLITRK1 Gene

Transcripts for SLITRK1 Gene

mRNA/cDNA for SLITRK1 Gene

(4) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(26) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLITRK1 Gene

SLIT and NTRK-like family, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLITRK1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLITRK1 Gene

No ASD Table

Relevant External Links for SLITRK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLITRK1 Gene

mRNA expression in normal human tissues for SLITRK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLITRK1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (8.8), Brain - Anterior cingulate cortex (BA24) (7.8), Brain - Cortex (7.5), Brain - Hippocampus (5.0), and Brain - Amygdala (4.9).

Protein differential expression in normal tissues for SLITRK1 Gene

This gene is overexpressed in Cerebrospinal fluid (32.2), Serum (12.7), Lung (11.9), and Kidney (8.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLITRK1 Gene

SOURCE GeneReport for Unigene cluster for SLITRK1 Gene Hs.415478

mRNA Expression by UniProt/SwissProt for SLITRK1 Gene

Tissue specificity: Expressed predominantly in the frontal lobe of the cerebral cortex of the brain. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors.
genes like me logo Genes that share expressions with SLITRK1: view

In Situ Assay Products

No data available for Expression partners for SLITRK1 Gene

Orthologs for SLITRK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLITRK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLITRK1 35
  • 95.45 (n)
  • 99.14 (a)
  • 99 (a)
(Canis familiaris)
Mammalia SLITRK1 35
  • 94.92 (n)
  • 99.28 (a)
  • 99 (a)
(Mus musculus)
Mammalia Slitrk1 35
  • 92.91 (n)
  • 97.56 (a)
Slitrk1 16
Slitrk1 36
  • 98 (a)
(Pan troglodytes)
Mammalia SLITRK1 35
  • 99.81 (n)
  • 99.86 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Slitrk1 35
  • 92.53 (n)
  • 97.41 (a)
(Monodelphis domestica)
Mammalia SLITRK1 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 2 (a)
-- 36
  • 1 (a)
(Gallus gallus)
Aves SLITRK1 35
  • 81.36 (n)
  • 89.31 (a)
  • 89 (a)
(Anolis carolinensis)
Reptilia SLITRK1 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slitrk1 35
  • 74.92 (n)
  • 83.88 (a)
(Danio rerio)
Actinopterygii LOC558743 35
  • 69 (n)
  • 72.59 (a)
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta sli 36
  • 10 (a)
(Caenorhabditis elegans)
Secernentea slt-1 36
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
Species with no ortholog for SLITRK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLITRK1 Gene

Gene Tree for SLITRK1 (if available)
Gene Tree for SLITRK1 (if available)

Paralogs for SLITRK1 Gene

Selected SIMAP similar genes for SLITRK1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLITRK1: view

Variants for SLITRK1 Gene

Sequence variations from dbSNP and Humsavar for SLITRK1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs3164 -- 83,877,374(+) ATATT(A/T)AAAAA utr-variant-3-prime
rs1046202 -- 83,877,375(-) TTTTT(A/T)TAATA utr-variant-3-prime
rs2152079 -- 83,884,334(+) CCACT(C/T)TGAGA upstream-variant-2KB
rs3737193 -- 83,878,283(+) CCATT(A/G)TAAAA utr-variant-3-prime
rs4286016 -- 83,882,775(+) CAGCA(A/T)TTTGA upstream-variant-2KB

Relevant External Links for SLITRK1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLITRK1 Gene

Disorders for SLITRK1 Gene

(2) OMIM Diseases for SLITRK1 Gene (609678)


  • Gilles de la Tourette syndrome (GTS) [MIM:137580]: Neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities. {ECO:0000269 PubMed:16224024}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
  • Trichotillomania (TTM) [MIM:613229]: A neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychological disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder. {ECO:0000269 PubMed:16224024}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLITRK1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLITRK1: view

No data available for Novoseek inferred disease relationships and Genatlas for SLITRK1 Gene

Publications for SLITRK1 Gene

  1. Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. (PMID: 14557068) Aruga J. … Mikoshiba K. (Gene 2003) 2 3 4 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  3. Sequence variants in SLITRK1 are associated with Tourette's syndrome. (PMID: 16224024) Abelson J.F. … State M.W. (Science 2005) 3 4 48
  4. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  5. Overrepresentation of rare variants in a specific ethnic group may confuse interpretation of association analyses. (PMID: 17035247) Keen-Kim D. … Freimer N.B. (Hum. Mol. Genet. 2006) 3 48

Products for SLITRK1 Gene

Sources for SLITRK1 Gene

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