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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLITRK1 Gene

protein-coding GIFtS: 57
GCID: GC13M084451

SLIT and NTRK-like family, member 1

(Previous name: leucine rich repeat containing 12 )
(Previous symbol: LRRC12)

Explore 14 diseases affiliated with
SLITRK1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SLIT And NTRK-Like Family, Member 1¹ ²		Leucine Rich Repeat Containing 12¹
LRRC12¹ ² ³		RP11-395N17.1²
KIAA1910¹ ³ ⁵		SLIT And NTRK-Like Protein 1²
Leucine-Rich Repeat-Containing Protein 12² ³		Slit And Trk Like Gene 1²
TTM² ⁵

External Ids:	HGNC: 20297¹	Entrez Gene: 114798²	Ensembl: ENSG00000178235⁷	OMIM: 609678⁵	UniProtKB: Q96PX8³

Export aliases for SLITRK1 gene to outside databases

Previous GC identifers: GC13M082251 GC13M082249 GC13M083349 GC13M065151

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLITRK1:

This intronless gene encodes a member of the SLITRK protein family. These proteins are integral membrane proteins that

are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology

with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to

neurotrophin receptors. The protein is thought to be involved in neurite outgrowth. Mutations in this gene may be

associated with Tourette syndrome.(provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: SLIK1_HUMAN, Q96PX8

Function: Enhances neuronal dendrite outgrowth

Gene Wiki entry for SLITRK1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLITRK1 gene promoter:
STAT1 STAT1beta Nkx2-5 CUTL1 STAT1alpha SRY POU2F1 POU2F1a POU2F1c
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLITRK1 promoter sequence

Search SABiosciences Chromatin IP Primers for SLITRK1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLITRK1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q31.1 Ensembl cytogenetic band: 13q31.1 HGNC cytogenetic band: 13q31.1

SLITRK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLITRK1 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M084451: view genomic region (about GC identifiers)

Start:	84,451,343 bp from pter	End:	84,456,528 bp from pter
Size:	5,186 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SLIK1_HUMAN, Q96PX8 (See protein sequence)

Recommended Name: SLIT and NTRK-like protein 1 precursor

Size: 696 amino acids; 77735 Da

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Developmental stage: At 20 weeks of gestation, expressed in multiple brain regions, including the developing

neo-cortical plate, subplate zone, striatum, globus pallidus, thalamus and subthalamus

Sequence caution: Sequence=BAB67803.1; Type=Erroneous initiation;

Secondary accessions: Q5U5I6 Q96SF9

Explore the universe of human proteins at neXtProt for SLITRK1: NX_Q96PX8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96PX8

SLITRK1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_443142.1

ENSEMBL proteins:

ENSP00000366288

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLITRK1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

SLITRK1 for ontologies About GeneDecksing

SLITRK1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SLITRK1
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	Uscn ELISAs and CLIAs for SLITRK1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLITRK1 for domains About GeneDecksing

4 InterPro domains/families:

IPR000483 Cys-rich_flank_reg_C

IPR000372 LRR-contain_N

IPR001611 Leu-rich_rpt

IPR003591 Leu-rich_rpt_typical-subtyp

Graphical View of Domain Structure for InterPro Entry Q96PX8

ProtoNet protein and cluster: Q96PX8

1 Blocks protein family: IPB001611 Leucine-rich repeat signature

UniProtKB/Swiss-Prot: SLIK1_HUMAN, Q96PX8

Similarity: Belongs to the SLITRK family

Similarity: Contains 12 LRR (leucine-rich) repeats

Similarity: Contains 2 LRRCT domains

Similarity: Contains 2 LRRNT domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SLIK1_HUMAN, Q96PX8

Function: Enhances neuronal dendrite outgrowth

miRNA Products:		miRTarBase miRNAs that target SLITRK1: hsa-mir-24-1 (MIRT005653)

		OriGene 3'-UTR Clone: SLITRK1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLITRK1
		8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate SLITRK1 (see all 35):
		hsa-miR-4291 hsa-miR-429 hsa-miR-517a hsa-miR-517c hsa-miR-4275 hsa-miR-570 hsa-miR-532-5p hsa-miR-3148

		SwitchGear 3'UTR luciferase reporter plasmid: SLITRK1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLITRK1 (see all 7) OriGene shRNA RFP: SLITRK1 OriGene siRNA: SLITRK1
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SLITRK1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLITRK1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLITRK1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SLITRK1 (NM_052910)
		Sino Biological Human cDNA Clone for SLITRK1
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SLITRK1
		Search LifeMap BioReagents cell lines for SLITRK1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLITRK1

Animal Models:
Mouse knock-outs for SLITRK1: Slitrk1^tm1Lex Slitrk1^tm1Jaru
5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Slitrk1):

behavior/neurological

growth/size

homeostasis/metabolism

mortality/aging

nervous system

SLITRK1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLITRK1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for SLITRK1 (Q96PX8^{2, 3} ENSP00000366288⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAB	P31946²^,³, ENSP00000300161⁴	MINT-8009119 I2D: score=1 STRING: ENSP00000300161

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007409	axonogenesis	IEA	--

SLITRK1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLITRK1
Search CenterWatch for drugs/clinical trials and news about SLITRK1 / SLIK1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLITRK1 gene:

NM_052910.1

Unigene Cluster for SLITRK1:

SLIT and NTRK-like family, member 1

Hs.415478 [show with all ESTs]

Unigene Representative Sequence: NM_052910

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000377084(uc001vlk.3)

miRNA Products:		OriGene 3'-UTR Clone: SLITRK1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLITRK1
		8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate SLITRK1 (see all 35):
		hsa-miR-4291 hsa-miR-429 hsa-miR-517a hsa-miR-517c hsa-miR-4275 hsa-miR-570 hsa-miR-532-5p hsa-miR-3148

		SwitchGear 3'UTR luciferase reporter plasmid: SLITRK1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLITRK1 (see all 7) OriGene shRNA RFP: SLITRK1 OriGene siRNA: SLITRK1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLITRK1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLITRK1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLITRK1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SLITRK1 (NM_052910)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLITRK1
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLITRK1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLITRK1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLITRK1

Additional cDNA sequence:

AB067497.1 AK299479.1 AY358289.1 BC051738.1

1 DOTS entry:

DT.91649135

24/26 AceView cDNA sequences (see all 26):

NM_052910 AB067497 BC051738 AY358289 AA677641 BF439516 Z45152 T31600

Z40879 F10062 BX496202 H08054 F12440 BX091443 BF932057 AI500170

AW962553 AI565671 BI546610 R35384 T82468 Z42346 T73996 R49685

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLITRK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCAATTAAT

About this image

SLITRK1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Sclerotome cells (Primary Cell)

Bone, Cartilage, Somite

HyStem+BMP4-induced SK11 cells (HyStem+BMP4 inductio...)

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLITRK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLITRK1

SOURCE GeneReport for Unigene cluster: Hs.415478

UniProtKB/Swiss-Prot: SLIK1_HUMAN, Q96PX8

Tissue specificity: Expressed predominantly in the frontal lobe of the cerebral cortex of the brain. Also expressed in

some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive

neuroectodermal tumors

SABiosciences Custom PCR Arrays for SLITRK1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLITRK1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLITRK1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SLITRK1 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLITRK1¹	SLIT and NTRK-like family, member 1	81.36(n) 89.31(a)		418798 XM_416993.3 XP_416993.2
lizard (Anolis carolinensis)	Reptilia	SLITRK1⁶	--	84(a)	1 ↔ 1	3(93916936-93919041)
zebrafish (Danio rerio)	Actinopterygii	LOC558743¹	SLIT and NTRK-like protein 1-like	69(n) 72.59(a)		558743 XM_682001.4 XP_687093.2

ENSEMBL Gene Tree for SLITRK1 (if available)
TreeFam Gene Tree for SLITRK1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLITRK1 gene

SLITRK2² SLITRK5² ELFN1² ELFN2² LRRC19² SLITRK3² SLITRK6² SLITRK4²

6 SIMAP similar genes for SLITRK1 using alignment to 1 protein entry: SLIK1_HUMAN:

DKFZp451E1911 SLITRK2 SLITRK4 SLITRK3 SLITRK5 SLITRK6

SLITRK1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191284403^1,2	C,	pathogenic	65152768(+)	`CCTACC/TGATCA`	1	--	ut3¹		0	--	--	--	--
rs17077405^1,2	C,F,H,	--	65150851(+)	`CTTCTA/GTGAGA`	1	--	ds500¹		10		NA NS CSA WA	1052
rs186069029^1,2	C,	--	65151383(+)	`CTGAGA/GTCTTT`	1	--	ut3¹		0	--	--	--	--
rs41557622^1,2	C,F,	--	65151895(-)	`TTGATT/ATAATT`	1	--	ut3¹		2		EU NA	300
rs9602286^1,2	C,	--	65152297(+)	`TTTCGC/TTNNNN`	1	--	ut3¹ ese³		2		CSA WA	120
rs9593836^1,2	C,F,H,	--	65152656(+)	`TTCCCT/GCAACA`	1	--	ut3¹		11		NS EA CSA WA NA	1608
rs57857456^1,2	C,	--	65152808(+)	`TATACT/CGTATT`	1	--	ut3¹		2		WA	120
rs7491932^1,2	C,H	--	65153894(+)	`CATCAG/TCACTT`	2	M L	mis¹ ese³		6		NS EA NA	506
rs138358044^1,2	C	--	65154971(+)	`ATAGGG/TCAGCG`	2	T P	mis¹		1		NA	4552
rs74099450^1,2	C,	--	65155803(+)	`GTAGGG/AAAAAA`	1	--	ut5¹		1		WA	2

HapMap Linkage Disequilibrium report for SLITRK1 (84451343 - 84456528 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLITRK1: --
Human Gene Mutation Database (HGMD): SLITRK1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLITRK1

DNA2.0 Custom Variant and Variant Library Synthesis for SLITRK1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLITRK1 for disorders           About GeneDecksing

OMIM gene information: 609678
OMIM disorders: 137580  613229
UniProtKB/Swiss-Prot: SLIK1_HUMAN, Q96PX8

Defects in SLITRK1 may be a cause of Gilles de la Tourette syndrome (GTS) [MIM:137580]. GTS is a neurologic

disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities

Defects in SLITRK1 may be a cause of trichotillomania (TTM) [MIM:613229]. It is a neuropsychiatric disorder

characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected

individuals may develop physical complications and often have overlapping psychologic disorders, such as Gilles de la

Tourette syndrome or obsessive-compulsive disorder

14 diseases for SLITRK1: About MalaCards

tourette syndrome gilles de la tourette syndrome obsessive-compulsive disorder primitive neuroectodermal tumor

trichotillomania neuroectodermal tumors myotonic dystrophy wilson disease

ganglioglioma oligodendroglioma astrocytoma glioblastoma

cerebritis neuronitis

7 diseases from the University of Copenhagen DISEASES database for SLITRK1:

Trichotillomania Gilles de la Tourette syndrome Stereotypic movement disorder Wilson disease

Neurotic excoriation Body dysmorphic disorder Kleptomania

Genetic Association Database (GAD): SLITRK1
Human Genome Epidemiology (HuGE) Navigator: SLITRK1 (7 documents)

Export disorders for SLITRK1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLITRK1 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with SLITRK1)

Utopia: connect your pdf to the dynamic
world of online information

Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. (PubMed id 14557068)^{1, 2, 3, 9} Aruga J.... Mikoshiba K. (2003)
Sequence variants in SLITRK1 are associated with Tourette's syndrome. (PubMed id 16224024)^{1, 2, 4} Abelson J.F.... State M.W. (2005)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2, 3} Clark H.F.... Gray A.M. (2003)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)^{1, 2} Nagase T....Ohara O. (2001)
Genome-wide association study of temperament in bipola r disorder reveals significant associations with three novel Loci. (PubMed id 22365631)¹ Greenwood T.A....Kelsoe J.R. (2012)
Mutant human embryonic stem cells reveal neurite and synapse formation defects in type 1 myotonic dystrophy. (PubMed id 21458401)¹ Marteyn A....Martinat C. (2011)
Additional support for the association of SLITRK1 var 321 and Tourette syndrome. (PubMed id 20351724)¹ O'Roak B.J....State M.W. (2010)
Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)¹ Trynka G....Wijmenga C. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 114798	HGNC: 20297	AceView: SLITRK1	Ensembl:ENSG00000178235	euGenes: HUgn114798
ECgene: SLITRK1	H-InvDB: SLITRK1

(According to HUGE)
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HUGE: KIAA1910

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLITRK1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLITRK1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SLITRK1 gene:
Search GeneIP for patents involving SLITRK1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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SLITRK1 Gene

SLIT and NTRK-like family, member 1

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SLITRK1 Gene

SLIT and NTRK-like family, member 1

Aliasesfor SLITRK1 gene

Summariesfor SLITRK1 gene

Genomic Viewsfor SLITRK1 gene

Proteinsfor SLITRK1 gene

Protein Domains /Familiesfor SLITRK1 gene

Functionfor SLITRK1 gene

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External Searches for SLITRK1 gene

Genome Databases showing SLITRK1 gene

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Specialized Databases showing SLITRK1 gene

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Aliases
for SLITRK1 gene

Summaries
for SLITRK1 gene

Genomic Views
for SLITRK1 gene

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for SLITRK1 gene

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Families
for SLITRK1 gene

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for SLITRK1 gene

Pathways & Interactions
for SLITRK1 gene

Drugs & Compounds
for SLITRK1 gene

Transcripts
for SLITRK1 gene

Expression
for SLITRK1 gene

Orthologs
for SLITRK1 gene

Paralogs
for SLITRK1 gene

Genomic Variants
for SLITRK1 gene

Disorders / Diseases
for SLITRK1 gene

Publications
for SLITRK1 gene

Intellectual Property
for SLITRK1 gene

Products
for SLITRK1 gene