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Aliases for SLIT3 Gene

Aliases for SLIT3 Gene

  • Slit Guidance Ligand 3 2 3 5
  • Multiple Epidermal Growth Factor-Like Domains Protein 5 3 4
  • Multiple EGF-Like Domains Protein 5 3 4
  • Slit-3 3 4
  • SLIL2 3 4
  • MEGF5 3 4
  • Slit (Drosophila) Homolog 3 2
  • Slit Homolog 3 (Drosophila) 2
  • Slit Homolog 3 3
  • KIAA0814 4
  • SLIT1 3
  • Slit2 3

External Ids for SLIT3 Gene

Previous HGNC Symbols for SLIT3 Gene

  • SLIL2

Previous GeneCards Identifiers for SLIT3 Gene

  • GC05M168328
  • GC05M168797
  • GC05M168024
  • GC05M168069
  • GC05M168074
  • GC05M168021
  • GC05M163191
  • GC05M168088

Summaries for SLIT3 Gene

Entrez Gene Summary for SLIT3 Gene

  • The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for SLIT3 Gene

SLIT3 (Slit Guidance Ligand 3) is a Protein Coding gene. Diseases associated with SLIT3 include Diaphragm Disease. Among its related pathways are Axon guidance and Developmental Biology. GO annotations related to this gene include calcium ion binding and Roundabout binding. An important paralog of this gene is NOTCH2NL.

UniProtKB/Swiss-Prot for SLIT3 Gene

  • May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.

Gene Wiki entry for SLIT3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLIT3 Gene

Genomics for SLIT3 Gene

Regulatory Elements for SLIT3 Gene

Enhancers for SLIT3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLIT3 on UCSC Golden Path with GeneCards custom track

Promoters for SLIT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLIT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLIT3 Gene

168,661,733 bp from pter
169,301,129 bp from pter
639,397 bases
Minus strand

Genomic View for SLIT3 Gene

Genes around SLIT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLIT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLIT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLIT3 Gene

Proteins for SLIT3 Gene

  • Protein details for SLIT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Slit homolog 3 protein
    Protein Accession:
    Secondary Accessions:
    • A6H8U9
    • J3KNP3
    • O95804
    • Q9UFH5

    Protein attributes for SLIT3 Gene

    1523 amino acids
    Molecular mass:
    167713 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA32466.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB59249.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLIT3 Gene


neXtProt entry for SLIT3 Gene

Proteomics data for SLIT3 Gene at MOPED

Post-translational modifications for SLIT3 Gene

  • Glycosylation at Asn 72, Asn 192, Asn 563, Asn 622, Asn 784, Asn 792, Asn 797, Asn 928, Asn 1008, Asn 1025, Asn 1181, Asn 1247, Thr 1295, and Asn 1406
  • Modification sites at PhosphoSitePlus

Other Protein References for SLIT3 Gene

Antibody Products

No data available for DME Specific Peptides for SLIT3 Gene

Domains & Families for SLIT3 Gene

Suggested Antigen Peptide Sequences for SLIT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 20 LRR (leucine-rich) repeats.
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 9 EGF-like domains.
  • Contains 1 laminin G-like domain.
  • Contains 4 LRRCT domains.
  • Contains 4 LRRNT domains.
  • Contains 20 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with SLIT3: view

No data available for Gene Families for SLIT3 Gene

Function for SLIT3 Gene

Molecular function for SLIT3 Gene

GENATLAS Biochemistry:
SLIT Drosophila homolog 3,expressed in the cerebellum and chyroid,ligand of GPC1,involved in histogenesis of central nervous system
UniProtKB/Swiss-Prot Function:
May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.
genes like me logo Genes that share phenotypes with SLIT3: view

Animal Models for SLIT3 Gene

MGI Knock Outs for SLIT3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLIT3

miRNA for SLIT3 Gene

miRTarBase miRNAs that target SLIT3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLIT3 Gene

Localization for SLIT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLIT3 Gene


Subcellular locations from

Jensen Localization Image for SLIT3 Gene COMPARTMENTS Subcellular localization image for SLIT3 gene
Compartment Confidence
extracellular 5
mitochondrion 5
plasma membrane 3
cytoskeleton 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for SLIT3 Gene

Pathways & Interactions for SLIT3 Gene

genes like me logo Genes that share pathways with SLIT3: view

Pathways by source for SLIT3 Gene

1 BioSystems pathway for SLIT3 Gene
3 Reactome pathways for SLIT3 Gene
1 KEGG pathway for SLIT3 Gene
1 GeneGo (Thomson Reuters) pathway for SLIT3 Gene

Interacting Proteins for SLIT3 Gene

Gene Ontology (GO) - Biological Process for SLIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007411 axon guidance IEA,IDA 11748139
GO:0008285 negative regulation of cell proliferation IEA --
GO:0021834 NOT chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration IDA 11748139
GO:0030308 negative regulation of cell growth IMP 18829537
GO:0035385 Roundabout signaling pathway IMP 18829537
genes like me logo Genes that share ontologies with SLIT3: view

No data available for SIGNOR curated interactions for SLIT3 Gene

Drugs & Compounds for SLIT3 Gene

No Compound Related Data Available

Transcripts for SLIT3 Gene

Unigene Clusters for SLIT3 Gene

Slit homolog 3 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLIT3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^
SP1: - - - -
SP2: -
SP4: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b · 32c ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37a · 37b
SP2: - - -
SP6: -

Relevant External Links for SLIT3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLIT3 Gene

mRNA expression in normal human tissues for SLIT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLIT3 Gene

This gene is overexpressed in Artery - Tibial (x4.3).

Protein differential expression in normal tissues from HIPED for SLIT3 Gene

This gene is overexpressed in Liver, secretome (32.0), Gallbladder (12.6), and Fetal ovary (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLIT3 Gene

SOURCE GeneReport for Unigene cluster for SLIT3 Gene Hs.552087

mRNA Expression by UniProt/SwissProt for SLIT3 Gene

Tissue specificity: Predominantly expressed in thyroid.
genes like me logo Genes that share expression patterns with SLIT3: view

Primer Products

No data available for Protein tissue co-expression partners for SLIT3 Gene

Orthologs for SLIT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLIT3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLIT3 35
  • 90.44 (n)
  • 92.75 (a)
SLIT3 36
  • 90 (a)
(Canis familiaris)
Mammalia SLIT3 35
  • 91.46 (n)
  • 95.08 (a)
SLIT3 36
  • 95 (a)
(Mus musculus)
Mammalia Slit3 35
  • 88.84 (n)
  • 94.02 (a)
Slit3 16
Slit3 36
  • 94 (a)
(Pan troglodytes)
Mammalia SLIT3 35
  • 93.94 (n)
  • 92.64 (a)
SLIT3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slit3 35
  • 88.71 (n)
  • 93.89 (a)
(Monodelphis domestica)
Mammalia SLIT3 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia SLIT3 36
  • 82 (a)
(Gallus gallus)
Aves SLIT3 35
  • 75.46 (n)
  • 81.79 (a)
SLIT3 36
  • 82 (a)
(Anolis carolinensis)
Reptilia SLIT3 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slit3 35
  • 73.09 (n)
  • 80.81 (a)
Str.13269 35
(Danio rerio)
Actinopterygii -- 35
slit3 35
  • 68.77 (n)
  • 70.34 (a)
slit3 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta sli 37
  • 41 (a)
sli 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea slt-1 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for SLIT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLIT3 Gene

Gene Tree for SLIT3 (if available)
Gene Tree for SLIT3 (if available)

Paralogs for SLIT3 Gene

Paralogs for SLIT3 Gene

(17) SIMAP similar genes for SLIT3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLIT3: view

Variants for SLIT3 Gene

Sequence variations from dbSNP and Humsavar for SLIT3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2305993 - 168,696,393(-) GTGTG(A/G)GATCA reference, missense
rs2288792 - 168,774,346(-) CCTGC(A/G)GGTGA reference, missense
rs10036727 - 168,753,076(+) ACAGC(C/T)GATCA reference, missense
rs891921 - 168,785,946(-) GATTG(C/T)CAAGG reference, missense
rs36052924 - 168,722,310(-) CAACC(A/G)GCTGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLIT3 Gene

Variant ID Type Subtype PubMed ID
esv2658777 CNV Deletion 23128226
esv273212 CNV Insertion 20981092
esv2516692 CNV Insertion 19546169
nsv512862 CNV Insertion 21212237
esv275039 CNV Loss 21479260
esv2731046 CNV Deletion 23290073
esv2731047 CNV Deletion 23290073
esv2731048 CNV Deletion 23290073
dgv360n21 CNV Loss 19592680
nsv462513 CNV Loss 19166990
esv273580 CNV Insertion 20981092
esv269740 CNV Insertion 20981092
nsv5122 CNV Loss 18451855
esv275423 CNV Loss 21479260
nsv328526 CNV Loss 16902084
esv28158 CNV Loss 19812545
esv2731049 CNV Deletion 23290073
esv2731050 CNV Deletion 23290073
esv2731052 CNV Deletion 23290073
esv989985 CNV Deletion 20482838
esv6957 OTHER Inversion 19470904
esv2391131 CNV Deletion 18987734
esv2731053 CNV Deletion 23290073

Variation tolerance for SLIT3 Gene

Residual Variation Intolerance Score: 18.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.53; 71.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLIT3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLIT3 Gene

Disorders for SLIT3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLIT3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
diaphragm disease
  • disease of diaphragm
- elite association - COSMIC cancer census association via MalaCards
Search SLIT3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SLIT3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLIT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLIT3 Gene

Publications for SLIT3 Gene

  1. Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. (PMID: 9813312) Itoh A. … Sakano S. (Brain Res. Mol. Brain Res. 1998) 2 3 4 23 67
  2. Identification of high-molecular-weight proteins with multiple EGF- like motifs by motif-trap screening. (PMID: 9693030) Nakayama M. … Ohara O. (Genomics 1998) 2 3
  3. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  4. SLIT3 is increased in supracervical human foetal membranes and in labouring myometrium and regulates pro-inflammatory mediators. (PMID: 24286238) Lim R. … Lappas M. (Am. J. Reprod. Immunol. 2014) 3
  5. Estrogen receptor (ER) agonists differentially regulate neuroangiogenesis in peritoneal endometriosis via the repellent factor SLIT3. (PMID: 25051436) Greaves E. … Saunders P.T. (Endocrinology 2014) 3

Products for SLIT3 Gene

Sources for SLIT3 Gene