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Aliases for SLIT3 Gene

Aliases for SLIT3 Gene

  • Slit Homolog 3 (Drosophila) 2 3
  • SLIL2 3 4 6
  • MEGF5 3 4 6
  • Multiple Epidermal Growth Factor-Like Domains Protein 5 3 4
  • Multiple EGF-Like Domains Protein 5 3 4
  • Slit-3 3 4
  • Slit (Drosophila) Homolog 3 2
  • Slit Homolog 3 Protein 3
  • KIAA0814 4
  • SLIT1 3
  • Slit2 3

External Ids for SLIT3 Gene

Previous HGNC Symbols for SLIT3 Gene

  • SLIL2

Previous GeneCards Identifiers for SLIT3 Gene

  • GC05M168328
  • GC05M168797
  • GC05M168024
  • GC05M168069
  • GC05M168074
  • GC05M168021
  • GC05M163191
  • GC05M168088

Summaries for SLIT3 Gene

Entrez Gene Summary for SLIT3 Gene

  • The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for SLIT3 Gene

SLIT3 (Slit Homolog 3 (Drosophila)) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include calcium ion binding and Roundabout binding. An important paralog of this gene is SLITRK3.

UniProtKB/Swiss-Prot for SLIT3 Gene

  • May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors

Gene Wiki entry for SLIT3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLIT3 Gene

Genomics for SLIT3 Gene

Regulatory Elements for SLIT3 Gene

Genomic Location for SLIT3 Gene

Start:
168,661,733 bp from pter
End:
169,301,129 bp from pter
Size:
639,397 bases
Orientation:
Minus strand

Genomic View for SLIT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLIT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLIT3 Gene

Proteins for SLIT3 Gene

  • Protein details for SLIT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75094-SLIT3_HUMAN
    Recommended name:
    Slit homolog 3 protein
    Protein Accession:
    O75094
    Secondary Accessions:
    • A6H8U9
    • J3KNP3
    • O95804
    • Q9UFH5

    Protein attributes for SLIT3 Gene

    Size:
    1523 amino acids
    Molecular mass:
    167713 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA32466.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB59249.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLIT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLIT3 Gene

Proteomics data for SLIT3 Gene at MOPED

Post-translational modifications for SLIT3 Gene

  • Glycosylation at Asn72, Asn192, Asn563, Asn622, Asn784, Asn792, Asn797, Asn928, Asn1008, Asn1025, Asn1181, Asn1247, Thr1295, and Asn1406
  • Modification sites at PhosphoSitePlus

Other Protein References for SLIT3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLIT3 Gene

Domains for SLIT3 Gene

Suggested Antigen Peptide Sequences for SLIT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75094

UniProtKB/Swiss-Prot:

SLIT3_HUMAN :
  • O75094
Domain:
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 9 EGF-like domains.
  • Contains 1 laminin G-like domain.
  • Contains 4 LRRCT domains.
  • Contains 4 LRRNT domains.
Similarity:
  • Contains 20 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with SLIT3: view

No data available for Gene Families for SLIT3 Gene

Function for SLIT3 Gene

Molecular function for SLIT3 Gene

GENATLAS Biochemistry:
SLIT Drosophila homolog 3,expressed in the cerebellum and chyroid,ligand of GPC1,involved in histogenesis of central nervous system
UniProtKB/Swiss-Prot Function:
May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors

Gene Ontology (GO) - Molecular Function for SLIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS 9813312
GO:0005515 protein binding --
GO:0048495 Roundabout binding IPI 15207848
genes like me logo Genes that share ontologies with SLIT3: view
genes like me logo Genes that share phenotypes with SLIT3: view

Animal Model Products

miRNA for SLIT3 Gene

miRTarBase miRNAs that target SLIT3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLIT3 Gene

Localization for SLIT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLIT3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLIT3 Gene COMPARTMENTS Subcellular localization image for SLIT3 gene
Compartment Confidence
extracellular 5
mitochondrion 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 19741192
GO:0005739 mitochondrion NAS 11443047
genes like me logo Genes that share ontologies with SLIT3: view

Pathways for SLIT3 Gene

genes like me logo Genes that share pathways with SLIT3: view

Pathways by source for SLIT3 Gene

1 BioSystems pathway for SLIT3 Gene
3 Reactome pathways for SLIT3 Gene
1 KEGG pathway for SLIT3 Gene
1 GeneGo (Thomson Reuters) pathway for SLIT3 Gene

Interacting Proteins for SLIT3 Gene

Gene Ontology (GO) - Biological Process for SLIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007411 axon guidance TAS --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0009887 organ morphogenesis IEA --
GO:0010629 negative regulation of gene expression IEA --
GO:0021834 NOT chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration IDA 11748139
genes like me logo Genes that share ontologies with SLIT3: view

Transcripts for SLIT3 Gene

Unigene Clusters for SLIT3 Gene

Slit homolog 3 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLIT3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLIT3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^
SP1: - - - -
SP2: -
SP3:
SP4: -
SP5:
SP6:

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b · 32c ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37a · 37b
SP1:
SP2: - - -
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for SLIT3 Gene

GeneLoc Exon Structure for
SLIT3
ECgene alternative splicing isoforms for
SLIT3

Expression for SLIT3 Gene

mRNA expression in normal human tissues for SLIT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLIT3 Gene

This gene is overexpressed in Artery - Tibial (4.3).

Protein differential expression in normal tissues for SLIT3 Gene

This gene is overexpressed in Liver, secretome (32.0), Gallbladder (12.6), and Fetal ovary (10.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLIT3 Gene

SOURCE GeneReport for Unigene cluster for SLIT3 Gene Hs.552087

mRNA Expression by UniProt/SwissProt for SLIT3 Gene

O75094-SLIT3_HUMAN
Tissue specificity: Predominantly expressed in thyroid.
genes like me logo Genes that share expressions with SLIT3: view

In Situ Assay Products

No data available for Expression partners for SLIT3 Gene

Orthologs for SLIT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLIT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLIT3 35
  • 90.44 (n)
  • 92.75 (a)
SLIT3 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLIT3 35
  • 91.46 (n)
  • 95.08 (a)
SLIT3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slit3 35
  • 88.84 (n)
  • 94.02 (a)
Slit3 16
Slit3 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLIT3 35
  • 93.94 (n)
  • 92.64 (a)
SLIT3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slit3 35
  • 88.71 (n)
  • 93.89 (a)
oppossum
(Monodelphis domestica)
Mammalia SLIT3 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLIT3 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLIT3 35
  • 75.46 (n)
  • 81.79 (a)
SLIT3 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLIT3 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slit3 35
  • 73.09 (n)
  • 80.81 (a)
Str.13269 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
slit3 35
  • 68.77 (n)
  • 70.34 (a)
slit3 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sli 37
  • 41 (a)
sli 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea slt-1 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
ManyToMany
Species with no ortholog for SLIT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLIT3 Gene

ENSEMBL:
Gene Tree for SLIT3 (if available)
TreeFam:
Gene Tree for SLIT3 (if available)

Paralogs for SLIT3 Gene

Selected SIMAP similar genes for SLIT3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLIT3: view

Variants for SLIT3 Gene

Sequence variations from dbSNP and Humsavar for SLIT3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs167124 -- 168,684,921(+) tgcgg(G/T)tgggg intron-variant
rs167194 -- 169,090,017(-) cacaa(G/T)tcacc intron-variant
rs172448 -- 169,084,375(-) agtca(A/G)aggtt intron-variant
rs172472 -- 169,193,087(+) TTGCC(A/G)TGTTC intron-variant
rs172473 -- 169,193,276(+) AAGCC(A/G)CTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLIT3 Gene

Variant ID Type Subtype PubMed ID
esv2658777 CNV Deletion 23128226
esv273212 CNV Insertion 20981092
esv2516692 CNV Insertion 19546169
nsv512862 CNV Insertion 21212237
esv275039 CNV Loss 21479260
esv2731046 CNV Deletion 23290073
esv2731047 CNV Deletion 23290073
esv2731048 CNV Deletion 23290073
dgv360n21 CNV Loss 19592680
nsv462513 CNV Loss 19166990
esv273580 CNV Insertion 20981092
esv269740 CNV Insertion 20981092
nsv5122 CNV Loss 18451855
esv275423 CNV Loss 21479260
nsv328526 CNV Loss 16902084
esv28158 CNV Loss 19812545
esv2731049 CNV Deletion 23290073
esv2731050 CNV Deletion 23290073
esv2731052 CNV Deletion 23290073
esv989985 CNV Deletion 20482838
esv6957 OTHER Inversion 19470904
esv2391131 CNV Deletion 18987734
esv2731053 CNV Deletion 23290073

Relevant External Links for SLIT3 Gene

HapMap Linkage Disequilibrium report
SLIT3
Human Gene Mutation Database (HGMD)
SLIT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLIT3 Gene

Disorders for SLIT3 Gene

(1) Novoseek inferred disease relationships for SLIT3 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2

Relevant External Links for SLIT3

Genetic Association Database (GAD)
SLIT3
Human Genome Epidemiology (HuGE) Navigator
SLIT3
genes like me logo Genes that share disorders with SLIT3: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for SLIT3 Gene

Publications for SLIT3 Gene

  1. Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. (PMID: 9813312) Itoh A. … Sakano S. (Brain Res. Mol. Brain Res. 1998) 2 3 4 23
  2. Identification of high-molecular-weight proteins with multiple EGF- like motifs by motif-trap screening. (PMID: 9693030) Nakayama M. … Ohara O. (Genomics 1998) 2 3 4
  3. Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis. (PMID: 10349621) Holmes G.P. … Little M.H. (Mech. Dev. 1998) 3 4
  4. Genetic structure adds power to detect schizophrenia susceptibility at SLIT3 in the Chinese Han population. (PMID: 15231749) Shi Y. … He L. (Genome Res. 2004) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for SLIT3 Gene

Sources for SLIT3 Gene

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