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Aliases for SLIT2 Gene

Aliases for SLIT2 Gene

  • Slit Guidance Ligand 2 2 3
  • Slit-2 3 4
  • SLIL3 3 4
  • Slit (Drosophila) Homolog 2 2
  • Slit Homolog 2 (Drosophila) 2

External Ids for SLIT2 Gene

Previous HGNC Symbols for SLIT2 Gene

  • SLIL3

Previous GeneCards Identifiers for SLIT2 Gene

  • GC04P020186
  • GC04P020338
  • GC04P019943
  • GC04P020006
  • GC04P019931
  • GC04P019604
  • GC04P020254
  • GC04P020255

Summaries for SLIT2 Gene

Entrez Gene Summary for SLIT2 Gene

  • This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for SLIT2 Gene

SLIT2 (Slit Guidance Ligand 2) is a Protein Coding gene. Diseases associated with SLIT2 include crohn's colitis and corneal neovascularization. Among its related pathways are Developmental Biology and Glypican 1 network. GO annotations related to this gene include calcium ion binding and identical protein binding. An important paralog of this gene is SLITRK3.

UniProtKB/Swiss-Prot for SLIT2 Gene

  • Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.

Gene Wiki entry for SLIT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLIT2 Gene

Genomics for SLIT2 Gene

Regulatory Elements for SLIT2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLIT2 Gene

Chromosome:
4
Start:
20,251,925 bp from pter
End:
20,620,561 bp from pter
Size:
368,637 bases
Orientation:
Plus strand

Genomic View for SLIT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLIT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLIT2 Gene

Proteins for SLIT2 Gene

  • Protein details for SLIT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94813-SLIT2_HUMAN
    Recommended name:
    Slit homolog 2 protein
    Protein Accession:
    O94813
    Secondary Accessions:
    • B7ZLR5
    • O95710
    • Q17RU3
    • Q9Y5Q7

    Protein attributes for SLIT2 Gene

    Size:
    1529 amino acids
    Molecular mass:
    169870 Da
    Quaternary structure:
    • Interacts with GREM1 (By similarity). Homodimer. Binds ROBO1 and ROBO2 with high affinity.

    Three dimensional structures from OCA and Proteopedia for SLIT2 Gene

    Alternative splice isoforms for SLIT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLIT2 Gene

Proteomics data for SLIT2 Gene at MOPED

Post-translational modifications for SLIT2 Gene

  • Glycosylation at Asn 66, Asn 186, Asn 564, Asn 623, Asn 794, Asn 799, Asn 1009, Asn 1010, Asn 1019, Asn 1183, Asn 1266, and Asn 1300
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SLIT2 Gene

Domains & Families for SLIT2 Gene

Suggested Antigen Peptide Sequences for SLIT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94813

UniProtKB/Swiss-Prot:

SLIT2_HUMAN :
  • The leucine-rich repeat domain is sufficient for guiding both axon projection and neuronal migration, in vitro.
  • Contains 20 LRR (leucine-rich) repeats.
Domain:
  • The leucine-rich repeat domain is sufficient for guiding both axon projection and neuronal migration, in vitro.
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 7 EGF-like domains.
  • Contains 1 laminin G-like domain.
  • Contains 4 LRRCT domains.
  • Contains 4 LRRNT domains.
Similarity:
  • Contains 20 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with SLIT2: view

No data available for Gene Families for SLIT2 Gene

Function for SLIT2 Gene

Molecular function for SLIT2 Gene

GENATLAS Biochemistry:
SLIT Drosophila homolog 2,expressed in the spinal cord,involved in early body axis formation and cell patterning of the neural-tube
UniProtKB/Swiss-Prot Function:
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.

Gene Ontology (GO) - Molecular Function for SLIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005095 GTPase inhibitor activity IDA 16439689
GO:0005509 calcium ion binding NAS 9813312
GO:0005515 protein binding IPI 10102268
GO:0008201 heparin binding IDA 17062560
GO:0042802 identical protein binding IPI 19498462
genes like me logo Genes that share ontologies with SLIT2: view
genes like me logo Genes that share phenotypes with SLIT2: view

Animal Models for SLIT2 Gene

MGI Knock Outs for SLIT2:

Animal Model Products

miRNA for SLIT2 Gene

miRTarBase miRNAs that target SLIT2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLIT2 Gene

Localization for SLIT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLIT2 Gene

Secreted. Note=The C-terminal cleavage protein is more diffusible than the larger N-terminal protein that is more tightly cell associated.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLIT2 Gene COMPARTMENTS Subcellular localization image for SLIT2 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SLIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0005615 extracellular space IDA 10102268
GO:0005737 cytoplasm IDA 18566128
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with SLIT2: view

Pathways & Interactions for SLIT2 Gene

genes like me logo Genes that share pathways with SLIT2: view

Pathways by source for SLIT2 Gene

1 KEGG pathway for SLIT2 Gene
1 GeneGo (Thomson Reuters) pathway for SLIT2 Gene

PCR Array Products

SIGNOR curated interactions for SLIT2 Gene

Activates:

Gene Ontology (GO) - Biological Process for SLIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001656 metanephros development IEA --
GO:0001657 ureteric bud development IMP 15130495
GO:0001701 in utero embryonic development IEA --
GO:0001933 negative regulation of protein phosphorylation IDA 18345009
GO:0002042 cell migration involved in sprouting angiogenesis IMP 19351956
genes like me logo Genes that share ontologies with SLIT2: view

Drugs & Compounds for SLIT2 Gene

(1) Additional Compounds for SLIT2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Aza-2deoxycytidine
genes like me logo Genes that share compounds with SLIT2: view

Transcripts for SLIT2 Gene

Unigene Clusters for SLIT2 Gene

Slit homolog 2 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLIT2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLIT2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:

ExUns: 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42a · 42b
SP1: - - -
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for SLIT2 Gene

GeneLoc Exon Structure for
SLIT2
ECgene alternative splicing isoforms for
SLIT2

Expression for SLIT2 Gene

mRNA expression in normal human tissues for SLIT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLIT2 Gene

This gene is overexpressed in Lung (x4.2).

Protein differential expression in normal tissues from HIPED for SLIT2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (37.2), Prostate (9.3), and Kidney (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLIT2 Gene



SOURCE GeneReport for Unigene cluster for SLIT2 Gene Hs.29802

mRNA Expression by UniProt/SwissProt for SLIT2 Gene

O94813-SLIT2_HUMAN
Tissue specificity: Fetal lung and kidney, and adult spinal cord. Weak expression in adult adrenal gland, thyroid, trachea and other tissues examined.
genes like me logo Genes that share expression patterns with SLIT2: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for SLIT2 Gene

Orthologs for SLIT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLIT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLIT2 35
  • 92.41 (n)
  • 98.1 (a)
SLIT2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLIT2 35
  • 88.95 (n)
  • 96.47 (a)
SLIT2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slit2 35
  • 89.52 (n)
  • 96.71 (a)
Slit2 16
Slit2 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLIT2 35
  • 99.41 (n)
  • 99.74 (a)
SLIT2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slit2 35
  • 89.22 (n)
  • 96.84 (a)
oppossum
(Monodelphis domestica)
Mammalia SLIT2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLIT2 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLIT2 35
  • 82.64 (n)
  • 93.51 (a)
SLIT2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLIT2 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slit2 35
  • 77.81 (n)
  • 88.6 (a)
Str.11776 35
zebrafish
(Danio rerio)
Actinopterygii slit2 35
  • 71.26 (n)
  • 80.21 (a)
slit2 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sli 37
  • 43 (a)
Tollo 37
  • 24 (a)
sli 35
  • 51.85 (n)
  • 47.19 (a)
sli 36
  • 45 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002793 35
  • 51.61 (n)
  • 47.74 (a)
worm
(Caenorhabditis elegans)
Secernentea slt-1 35
  • 48.46 (n)
  • 41.01 (a)
slt-1 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
ManyToMany
Species with no ortholog for SLIT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLIT2 Gene

ENSEMBL:
Gene Tree for SLIT2 (if available)
TreeFam:
Gene Tree for SLIT2 (if available)

Paralogs for SLIT2 Gene

Pseudogenes.org Pseudogenes for SLIT2 Gene

genes like me logo Genes that share paralogs with SLIT2: view

Variants for SLIT2 Gene

Sequence variations from dbSNP and Humsavar for SLIT2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_018098 -
VAR_018099 -

Structural Variations from Database of Genomic Variants (DGV) for SLIT2 Gene

Variant ID Type Subtype PubMed ID
nsv878736 CNV Loss 21882294
nsv878737 CNV Gain+Loss 21882294
dgv5487n71 CNV Loss 21882294
nsv461287 CNV Loss 19166990
nsv878740 CNV Gain 21882294
esv2727259 CNV Deletion 23290073
esv1004503 CNV Deletion 20482838
esv2863 CNV Deletion 18987735
esv2727260 CNV Deletion 23290073
dgv925e199 CNV Deletion 23128226
esv25235 CNV Loss 19812545
nsv821168 CNV Deletion 20802225
nsv878741 CNV Loss 21882294
nsv527095 CNV Gain 19592680
nsv878742 CNV Loss 21882294
nsv822502 CNV Gain 20364138
esv2727261 CNV Deletion 23290073
esv2676982 CNV Deletion 23128226
nsv829875 CNV Gain+Loss 17160897
esv269617 CNV Insertion 20981092
esv2487197 CNV Deletion 19546169
nsv292967 CNV Insertion 16902084
nsv516999 CNV Loss 19592680
esv2672092 CNV Deletion 23128226
nsv442896 CNV CNV 18776908
esv2421650 CNV Deletion 20811451
nsv818221 CNV Loss 17921354
nsv514200 CNV Loss 21397061
nsv437913 CNV Loss 16468122
nsv4263 CNV Insertion 18451855

Variation tolerance for SLIT2 Gene

Residual Variation Intolerance Score: 2.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 44.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLIT2 Gene

HapMap Linkage Disequilibrium report
SLIT2
Human Gene Mutation Database (HGMD)
SLIT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLIT2 Gene

Disorders for SLIT2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLIT2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
crohn's colitis
corneal neovascularization
  • corneal neovascularization nos
- elite association
Search SLIT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SLIT2

Genetic Association Database (GAD)
SLIT2
Human Genome Epidemiology (HuGE) Navigator
SLIT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLIT2
genes like me logo Genes that share disorders with SLIT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLIT2 Gene

Publications for SLIT2 Gene

  1. Potential anti-angiogenic role of Slit2 in corneal neovascularization. (PMID: 20298689) Han X. … Zhang M.C. (Exp. Eye Res. 2010) 23 67
  2. Slit2 inhibits glioma cell invasion in the brain by suppression of Cdc42 activity. (PMID: 20008733) Yiin J.J. … Cheng S.Y. (Neuro-oncology 2009) 23 67
  3. Mutations in the ROBO2 and SLIT2 genes are rare causes of familial vesico-ureteral reflux. (PMID: 19350278) Zu S. … NordenskjAPld A. (Pediatr. Nephrol. 2009) 23 67
  4. Novel regulated expression of the SLIT/ROBO pathway in the ovary: possible role during luteolysis in women. (PMID: 18566128) Dickinson R.E. … Duncan W.C. (Endocrinology 2008) 23 67
  5. Slit2 involvement in glioma cell migration is mediated by Robo1 receptor. (PMID: 17968499) Mertsch S. … Senner V. (J. Neurooncol. 2008) 23 67

Products for SLIT2 Gene

Sources for SLIT2 Gene

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