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SLIT2 Gene

protein-coding   GIFtS: 67
GCID: GC04P020254

Slit Homolog 2 (Drosophila)

(Previous name: slit (Drosophila) homolog 2)
(Previous symbol: SLIL3)
  Search for SLIT2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Slit Homolog 2 (Drosophila)1 2
SLIL31 2 3
Slit-22 3
Slit (Drosophila) Homolog 21
Slit Homolog 2 Protein2

External Ids:    HGNC: 110861   Entrez Gene: 93532   Ensembl: ENSG000001451477   OMIM: 6037465   UniProtKB: O948133   

Export aliases for SLIT2 gene to outside databases

Previous GC identifers: GC04P020186 GC04P020338 GC04P019943 GC04P020006 GC04P019931 GC04P019604


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLIT2 Gene:
SLIT2 (slit homolog 2 (Drosophila)) is a protein-coding gene. GO annotations related to this gene include identical protein binding and calcium ion binding. An important paralog of this gene is SLITRK5.

UniProtKB/Swiss-Prot: SLIT2_HUMAN, O94813
Function: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by
interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the
ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be
essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline
crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding
commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the
attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a
ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only
commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to
function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their
appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal
ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in
neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product,
repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces
branching of DRG axons. Seems to be involved in regulating leukocyte migration

Gene Wiki entry for SLIT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006316.17  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLIT2 gene promoter:
         TBP   STAT5A   Nkx2-5   E4BP4   AP-2gamma   AREB6   TFIID   Chx10   ARP-1   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLIT2 promoter sequence
   Search Chromatin IP Primers for SLIT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLIT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.2   Ensembl cytogenetic band:  4p15.31   HGNC cytogenetic band: 4p15.2

SLIT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLIT2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P020254:  view genomic region     (about GC identifiers)

Start:
20,254,883 bp from pter      End:
20,622,184 bp from pter
Size:
367,302 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SLIT2_HUMAN, O94813 (See protein sequence)
Recommended Name: Slit homolog 2 protein precursor  
Size: 1529 amino acids; 169870 Da
Subunit: Interacts with GREM1 (By similarity). Homodimer. Binds ROBO1 and ROBO2 with high affinity
4 PDB 3D structures from and Proteopedia for SLIT2:
2V70 (3D)        2V9S (3D)        2V9T (3D)        2WFH (3D)    
Secondary accessions: B7ZLR5 O95710 Q17RU3 Q9Y5Q7
Alternative splicing: 3 isoforms:  O94813-1   O94813-2   O94813-3   

Explore the universe of human proteins at neXtProt for SLIT2: NX_O94813

Explore proteomics data for SLIT2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn66, Asn186, Asn564, Asn623, Asn794, Asn799, Asn1009, Asn1010, Asn1019, Asn1183,
                                 Asn1266, Asn1300

  • See SLIT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001276064.1  NP_001276065.1  NP_004778.1  

    ENSEMBL proteins: 
     ENSP00000427548   ENSP00000422591   ENSP00000273739   ENSP00000422261   ENSP00000426356  
     ENSP00000421975   ENSP00000425609   ENSP00000423179  
    Reactome Protein details: O94813

    SLIT2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SLIT2
    OriGene Protein Over-expression Lysate for SLIT2
    OriGene MassSpec for SLIT2
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    GenScript Custom Purified and Recombinant Proteins Services for SLIT2
    Novus Biologicals SLIT2 Protein
    Novus Biologicals SLIT2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SLIT2 

    SLIT2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SLIT2
    R&D Systems Antibodies for SLIT2
    OriGene Antibodies for SLIT2
    OriGene Custom Antibody Services for SLIT2
    Novus Biologicals SLIT2 Antibodies
    Abcam antibodies for SLIT2
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for SLIT2
    LSBio Antibodies in human, mouse, rat for SLIT2

    SLIT2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLIT2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SLIT2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 14):
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G

    Graphical View of Domain Structure for InterPro Entry O94813

    ProtoNet protein and cluster: O94813

    Selected Blocks protein domains (see all 7):
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature
    IPB001791 Laminin G


    UniProtKB/Swiss-Prot: SLIT2_HUMAN, O94813
    Domain: The leucine-rich repeat domain is sufficient for guiding both axon projection and neuronal migration, in
    vitro
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 7 EGF-like domains
    Similarity: Contains 1 laminin G-like domain
    Similarity: Contains 20 LRR (leucine-rich) repeats
    Similarity: Contains 4 LRRCT domains
    Similarity: Contains 4 LRRNT domains


    Find genes that share domains with SLIT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLIT2_HUMAN, O94813
    Function: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by
    interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the
    ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be
    essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline
    crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding
    commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the
    attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a
    ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only
    commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to
    function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their
    appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal
    ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in
    neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product,
    repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces
    branching of DRG axons. Seems to be involved in regulating leukocyte migration

         Genatlas biochemistry entry for SLIT2:
    SLIT Drosophila homolog 2,expressed in the spinal cord,involved in early body axis formation and cell patterning
    of the neural-tube

         Summary: 
    During embryonic development, SLIT2 as signaling molecule affects the following cells:       fully expand
    Brain: Fetal Dopaminergic Neurons (Ventral Tegmental Area), Fetal Dopaminergic Neurons (Substantia Nigra pars Compacta)      fully expand to see all 2 cells
    Kidney: Metanephric Mesenchyme Cells (Metanephric Mesenchyme)

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005095GTPase inhibitor activity IDA16439689
    GO:0005509calcium ion binding NAS9813312
    GO:0005515protein binding IPI10102268
    GO:0008201heparin binding IDA17062560
    GO:0042802identical protein binding IPI19498462
         
    Find genes that share ontologies with SLIT2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLIT2:
     Cell cycle / mitosis defect 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slit2):
     cellular  digestive/alimentary  endocrine/exocrine gland  integument  mortality/aging 
     nervous system  renal/urinary system 

    Find genes that share phenotypes with SLIT2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slit2tm1Matl for SLIT2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLIT2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLIT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLIT2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLIT2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLIT2:
    hsa-mir-330-3p (MIRT043835)

    Block miRNA regulation of human, mouse, rat SLIT2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate SLIT2:
    hsa-miR-3671 hsa-miR-338-5p hsa-miR-607 hsa-miR-205* hsa-miR-1264 hsa-miR-26b* hsa-miR-548c-3p hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidSLIT2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLIT2
    Predesigned siRNA for gene silencing in human, mouse, rat SLIT2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLIT2

    Clone
    Products:
         
    OriGene clones in human, mouse for SLIT2 (see all 6)
    OriGene ORF clones in mouse, rat for SLIT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLIT2 (NM_004787)
    Sino Biological Human cDNA Clone for SLIT2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLIT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLIT2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLIT2
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLIT2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLIT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SLIT2_HUMAN, O94813: Secreted. Note=The C-terminal cleavage protein is more diffusible than the larger N-terminal
    protein that is more tightly cell associated
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA10102268
    GO:0005737cytoplasm IDA18566128
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IDA10102268

    Find genes that share ontologies with SLIT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLIT2 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Cytoskeleton remodeling Slit Robo signaling0.92
    2Signaling by Robo receptor
    Regulation of Commissural axon pathfinding by Slit and Robo0.00
    Inactivation of Cdc42 and Rac0.00
    Activation of Rac0.00
    Role of Abl in Robo-Slit signaling0.00
    Signaling by Robo receptor
    3L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    4Spinal Cord Injury
    Spinal Cord Injury
    5Signaling by Slit
    Signaling by Slit


    Find genes that share SuperPaths with SLIT2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SLIT2
        Guidance Cues and Growth Cone Motility
    Signaling by Slit

    1 GeneGo (Thomson Reuters) Pathway for SLIT2
        Development Slit-Robo signaling

    2 BioSystems Pathways for SLIT2
        Spinal Cord Injury
    Glypican 1 network


    Selected Reactome Pathways for SLIT2 (see all 6)
        Regulation of Commissural axon pathfinding by Slit and Robo
    Inactivation of Cdc42 and Rac
    Netrin-1 signaling
    Role of Abl in Robo-Slit signaling
    Signaling by Robo receptor


    1 Kegg Pathway  (Kegg details for SLIT2):
        Axon guidance

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLIT2: 
              Neurogenesis in human mouse rat
              Lung Cancer in human mouse rat
              Breast Cancer in human mouse rat
              Chemokines & Receptors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLIT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SLIT2 (O948131, 2, 3 ENSP000002737394) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLIT2O948131, 2EBI-1236865,EBI-1236865 MINT-7218946 MINT-7218959
    GPC1P350523, ENSP000002640394I2D: score=3 STRING: ENSP00000264039
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    ABL2P426843, ENSP000003565954I2D: score=1 STRING: ENSP00000356595
    ENAHQ8N8S73, ENSP000003558094I2D: score=1 STRING: ENSP00000355809
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 49):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001656metanephros development IEA--
    GO:0001657ureteric bud development IMP15130495
    GO:0001701in utero embryonic development IEA--
    GO:0001933negative regulation of protein phosphorylation IDA18345009
    GO:0002042cell migration involved in sprouting angiogenesis IMP19351956

    Find genes that share ontologies with SLIT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLIT2

    1 Novoseek inferred chemical compound relationship for SLIT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 60.8 3 12881718 (1), 12615722 (1)



    Find genes that share compounds with SLIT2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLIT2 gene (3 alternative transcripts): 
    NM_001289135.1  NM_001289136.1  NM_004787.2  

    Unigene Cluster for SLIT2:

    Slit homolog 2 (Drosophila)
    Hs.29802  [show with all ESTs]
    Unigene Representative Sequence: AF055585
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503823 ENST00000504154(uc003gpr.1) ENST00000273739(uc003gps.1)
    ENST00000503837 ENST00000508824 ENST00000509099 ENST00000509394 ENST00000511508
    ENST00000509941 ENST00000512993 ENST00000508541
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate SLIT2:
    hsa-miR-3671 hsa-miR-338-5p hsa-miR-607 hsa-miR-205* hsa-miR-1264 hsa-miR-26b* hsa-miR-548c-3p hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidSLIT2 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLIT2 (NM_004787)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLIT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLIT2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SLIT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLIT2
      QuantiTect SYBR Green Assays in human, mouse, rat SLIT2
      QuantiFast Probe-based Assays in human, mouse, rat SLIT2

    Additional mRNA sequence: 

    AB017168.1 AF055585.1 AF133270.1 AK027326.1 AK126459.1 AK308444.1 BC117190.1 BC143978.1 

    5 DOTS entries:

    DT.100743844  DT.313020  DT.412654  DT.99996021  DT.102825342 

    Selected AceView cDNA sequences (see all 83):

    AK126459 BU147452 BU682523 AB017168 CA395227 AI086363 AK027326 BM554858 
    NM_004787 BM970707 BI494498 AW294515 BF939447 BQ015028 BE876256 AA357860 
    BG211512 BX099663 AA055019 AA486868 BV167627 AI418415 BF112143 AI690653 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLIT2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
    SP1:                                      -     -     -     -                             -                                                           -         
    SP2:                                      -     -     -     -                             -                                         -                 -         
    SP3:                                      -     -     -     -                                                                       -                 -         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42a · 42b
    SP1:                                                  -                                   -                                   -                           
    SP2:                                                  -                                   -                                   -                           
    SP3:                                                  -                                   -                                   -                           
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for SLIT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLIT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGACTAAT
    SLIT2 Expression
    About this image


    SLIT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             Early Ameloblasts Dental Enamel
     
     Epithelial Cells
             Early Ameloblasts Dental Enamel
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
    SLIT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLIT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.29802

    UniProtKB/Swiss-Prot: SLIT2_HUMAN, O94813
    Tissue specificity: Fetal lung and kidney, and adult spinal cord. Weak expression in adult adrenal gland, thyroid,
    trachea and other tissues examined

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLIT2: 
              Neurogenesis in human mouse rat
              Lung Cancer in human mouse rat
              Breast Cancer in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLIT2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slit21 , 5 slit homolog 2 (Drosophila)1, 5 89.52(n)1
    96.71(a)1
      5 (26.05 cM)5
    205631  NM_178804.31  NP_848919.31 
     479831555 
    chicken
    (Gallus gallus)
    Aves SLIT21 slit homolog 2 (Drosophila) 82.64(n)
    93.51(a)
      373967  NM_001267075.1  NP_001254004.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLIT26
    slit homolog 2 (Drosophila)
    92(a)
    1 ↔ 1
    5(75616186-75737578)
    African clawed frog
    (Xenopus laevis)
    Amphibia AY046070.12   -- 78.64(n)    AY046070.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slit22 slit (Drosophila) homolog 2 74.37(n)   80353  AF210321.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sli1 , 3 axon guidance3
    slit1
    43(a)
    (best of 2)3
    51.85(n)1
    47.19(a)1
      367461  NM_001274088.11  NP_001261017.11 
    worm
    (Caenorhabditis elegans)
    Secernentea slt-11 slt-1 48.46(n)
    41.01(a)
      181562  NM_078036.5  NP_510437.2 


    ENSEMBL Gene Tree for SLIT2 (if available)
    TreeFam Gene Tree for SLIT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLIT2 gene
    SLITRK52  ISLR2  SLIT12  SLIT32  SLITRK62  LRRC382  LRRC262  SLITRK12  
    SLITRK42  LRTM12  LRRC522  LRRC172  SLITRK22  LRTM22  SLITRK32  LRRC552  
    ISLR22  LRRC242  
    Selected SIMAP similar genes for SLIT2 using alignment to 7 protein entries:     SLIT2_HUMAN (see all proteins) (see all similar genes):
    SLIT1    SLIT3    F9    DCN    NOTCH3    PODN
    PODNL1    LINGO2    LRIG3(NM_001136051)-ROS1    LRIG3(NM_153377)-ROS1    LRRC15    AGRN
    ASPN    FAT3    LINGO1    LGR6    LRRTM4    NGL1

    Find genes that share paralogs with SLIT2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SLIT2
    PGOHUM00000245861


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLIT2 (see all 7178)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420991481,2
    Cuntested119948668(+) CATATC/TGCGGT 2 I syn10--------
    rs1393681571,2
    C,Funtested119967383(+) GTGCCG/AATGCA 2 /P syn12Minor allele frequency- A:0.00NA EU 5839
    rs1457938841,2
    --19602291(+) AGGGGA/GCGAGC 1 -- us2k10--------
    rs1914167141,2
    --19602397(+) TCCCAC/GAGCGG 1 -- us2k10--------
    rs121083081,2
    C,F,A--19602402(+) GAGCGG/CAGCCA 1 -- us2k12Minor allele frequency- C:0.50NA 4
    rs1821715311,2
    --19602509(+) TTATTC/TGGGAA 1 -- us2k10--------
    rs1889511171,2
    --19602529(+) CGGCGG/TAGCTT 1 -- us2k10--------
    rs1932535671,2
    --19602649(+) GCCCAA/GGCGCA 1 -- us2k10--------
    rs1167278831,2
    C,F--19602697(+) GCTGAG/TCAGAA 1 -- us2k11Minor allele frequency- T:0.10WA 118
    rs1853963731,2
    C--19602721(+) GGGCCC/TGCAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLIT2 (20254883 - 20504883 bp, first 250kb of SLIT2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLIT2 (see all 30):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672092CNV Deletion23128226
    esv2727261CNV Deletion23290073
    esv2421650CNV Deletion20811451
    esv2487197CNV Deletion19546169
    dgv925e199CNV Deletion23128226
    esv2863CNV Deletion18987735
    nsv821168CNV Deletion20802225
    esv2727259CNV Deletion23290073
    esv2676982CNV Deletion23128226
    esv2727260CNV Deletion23290073

    Human Gene Mutation Database (HGMD): SLIT2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLIT2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLIT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603746    OMIM disorders: --


    Find genes that share disorders with SLIT2           About GenesLikeMe

    6 Novoseek inferred disease relationships for SLIT2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 46.2 39 12881718 (9), 20008733 (7), 17968499 (5), 15534609 (2) (see all 5)
    colorectal carcinoma 31 1 12615722 (1)
    cancer 23.4 9 14735202 (2), 18201275 (1), 18566128 (1), 20008733 (1) (see all 5)
    colorectal cancer 21.6 6 12615722 (4), 15534609 (1)
    breast cancer 13.9 13 12384551 (6), 17268810 (2), 15534609 (1), 14735202 (1)
    tumors 8.71 19 12384551 (6), 12615722 (3), 18201275 (2), 16685377 (2) (see all 5)

    Genetic Association Database (GAD): SLIT2
    Human Genome Epidemiology (HuGE) Navigator: SLIT2 (17 documents)

    Export disorders for SLIT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLIT2 gene, integrated from 10 sources (see all 114):
    (articles sorted by number of sources associating them with SLIT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. (PubMed id 9813312)1, 2, 3 Itoh A.... Sakano S. (Brain Res. Mol. Brain Res. 1998)
    2. Frequent epigenetic inactivation of the SLIT2 gene in gliomas. (PubMed id 12881718)1, 4, 9 Dallol A....Latif F. (Oncogene 2003)
    3. Slit2 is a repellent for retinal ganglion cell axons. (PubMed id 10864954)1, 2, 9 Niclou S.P.... Raper J.A. (J. Neurosci. 2000)
    4. Mutations in the ROBO2 and SLIT2 genes are rare causes of familial vesico-ureteral reflux. (PubMed id 19350278)1, 4, 9 Zu S....NordenskjAPld A. (Pediatr. Nephrol. 2009)
    5. Structural insights into the Slit-Robo complex. (PubMed id 17848514)1, 2, 9 Morlot C.... McCarthy A.A. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    6. Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis. (PubMed id 10349621)1, 2, 9 Holmes G.P....Little M.H. (Mech. Dev. 1998)
    7. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    8. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9353 HGNC: 11086 AceView: SLIT2 Ensembl:ENSG00000145147 euGenes: HUgn9353
    ECgene: SLIT2 Kegg: 9353 H-InvDB: SLIT2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLIT2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLIT2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLIT2 gene:
    Search GeneIP for patents involving SLIT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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