Aliases for SLIT2 Gene
External Ids for SLIT2 Gene
Previous HGNC Symbols for SLIT2 Gene
Previous GeneCards Identifiers for SLIT2 Gene
GeneCards Summary for SLIT2 Gene
SLIT2 (Slit Homolog 2 (Drosophila)) is a Protein Coding gene. Diseases associated with SLIT2 include crohn's colitis. Among its related pathways are L1CAM interactions and Glypican 1 network. GO annotations related to this gene include calcium ion binding and identical protein binding. An important paralog of this gene is SLITRK3.
UniProtKB/Swiss-Prot for SLIT2 Gene
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.