SLIT2 Gene
protein-coding GIFtS : 65 GCID: GC04 P020254
slit homolog 2 (Drosophila) slit (Drosophila) homolog 2 )SLIL3 )
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Aliasesfor SLIT2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Slit Homolog 2 (Drosophila) 1 2 SLIL31 2 3 Slit-21 2 3 Slit (Drosophila) Homolog 21 Slit Homolog 2 Protein2
Export aliases for SLIT2 gene to outside databases Previous GC identifers: GC04P020186 GC04P020338 GC04P019943 GC04P020006 GC04P019931 GC04P019604
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Summariesfor SLIT2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: SLIT2_HUMAN, O94813 Function : Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated byinteraction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration Gene Wiki entry for SLIT2
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Genomic Viewsfor SLIT2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_006316.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SLIT2 gene promoter:TBP STAT5A Nkx2-5 E4BP4 AP-2gamma AREB6 TFIID Chx10 ARP-1 Msx-1 Other transcription factors Search SABiosciences Chromatin IP Primers for SLIT2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4p15.2 Ensembl cytogenetic band: 4p15.31 HGNC cytogenetic band: 4p15.2 SLIT2 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P020254: view genomic region
(about GC identifiers )
Start: 20,254,883 bp from pter End:
20,622,184 bp from pter
Size: 367,302 bases Orientation:
plus strand
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Proteinsfor SLIT2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SLIT2_HUMAN, O94813 See
protein sequence )Recommended Name: Size : 1529 amino acids; 169870 DaSubunit : Interacts with GREM1 (By similarity). Homodimer. Binds ROBO1 and ROBO2 with high affinitySubcellular location : Secreted. Note=The C-terminal cleavage protein is more diffusible than the larger N-terminalprotein that is more tightly cell associated
4 PDB 3D structures from :2V70 (3D) 2V9S (3D) 2V9T (3D) 2WFH (3D) Secondary accessions : B7ZLR5 O95710 Q17RU3 Q9Y5Q7Alternative splicing : 3 isoforms : O94813-1 O94813-2 O94813-3 Explore the universe of human proteins at neXtProt for SLIT2: NX_O94813 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O94813 SLIT2 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_004778.1 ENSEMBL proteins: ENSP00000427548 ENSP00000422591 ENSP00000273739 ENSP00000422261 ENSP00000426356 ENSP00000421975 ENSP00000425609 ENSP00000423179 Reactome Protein details: O94813 Human Recombinant Protein Products: Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing SLIT2 Antibody Products: Assay Products for SLIT2:
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Protein
Domains /for SLIT2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/14 InterPro domains/families (see all 14 ):
Graphical View of Domain Structure for InterPro Entry O94813 ProtoNet protein and cluster: O94813
5/7 Blocks protein families (see all 7 ): IPB000152 IPB000372 IPB000483 IPB001611 IPB001791 UniProtKB/Swiss-Prot: SLIT2_HUMAN, O94813 Domain : The leucine-rich repeat domain is sufficient for guiding both axon projection and neuronal migration, in vitroSimilarity : Contains 1 CTCK (C-terminal cystine knot-like) domainSimilarity : Contains 7 EGF-like domainsSimilarity : Contains 1 laminin G-like domainSimilarity : Contains 20 LRR (leucine-rich) repeatsSimilarity : Contains 4 LRRCT domainsSimilarity : Contains 4 LRRNT domains
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Functionfor SLIT2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: SLIT2_HUMAN, O94813 Function : Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated byinteraction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration
Genatlas biochemistry entry for SLIT2 SLIT Drosophila homolog 2,expressed in the spinal cord,involved in early body axis formation and cell patterning of the neural-tube Summary: During embryonic development, SLIT2 as signaling molecule affects the following cells: Embryonic Dopaminergic Neurons in Substantia Nigra pars Compacta , Embryonic Dopaminergic Neurons in Substantia Nigra pars Compacta (see all 5 ). Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 2 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SLIT2 (NM_004787 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLIT2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLIT2
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLIT2
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9 ): About this table
About GeneDecksing 1 GenomeRNAi human phenotype for SLIT2 :Animal Models: Slit2 tm1Matl for SLIT25 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slit2) :About GeneDecksing
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Pathways & Interactionsfor SLIT2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/11 super-pathways (see all 11 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Axon guidance 2 Activation of Rac 3 Axon guidance 4 Cytoskeleton remodeling Slit-Robo signaling 5 Regulation of Commissural axon pathfinding by Slit and Robo
Pathway sources See GeneCards unified pathways Show all pathways 1 2 1 1 5/10 (see all 10 )1 (Kegg details for SLIT2) :About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLIT2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)5/34 Interacting proteins for SLIT2 (O94813 2 , 3 ENSP00000273739 4 via UniProtKB, MINT, STRING , and/or I2D (see all 34 )About this table Gene Ontology (GO): 5/48 biological process terms (GO ID links to tree view) (see all 48 ): About this table
About GeneDecksing
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Drugs & Compoundsfor SLIT2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for SLIT2 1 Novoseek chemical compound relationship for SLIT2 gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
5-aza-2'deoxycytidine
60.8
3
12881718 (1), 12615722 (1)
SLIT2
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Transcriptsfor SLIT2 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SLIT2 gene: NM_004787.1 Unigene Cluster for SLIT2:
Slit homolog 2 (Drosophila) Hs.29802 [show with all ESTs ] Unigene Representative Sequence: AF055585 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000503823 ENST00000504154 (uc003gpr.1 ) ENST00000273739 (uc003gps.1 )ENST00000503837 ENST00000508824 ENST00000509099 ENST00000509394 ENST00000511508 ENST00000509941 ENST00000512993 ENST00000508541 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 2 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SLIT2 (NM_004787 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLIT2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLIT2
Additional cDNA sequence: AB017168.1 AF055585.1 AF133270.1 AK027326.1 AK126459.1 AK308444.1 BC117190.1 BC143978.1
5 DOTS entries : DT.100743844 DT.313020
DT.412654 DT.99996021 DT.102825342 24/83 AceView cDNA sequences (see all 83 ):
BM554858 BM970707 AB017168 AK126459 BU682523 BU147452 AK027326 CA395227 AI086363 NM_004787 BI494498 AI090944 AA486868 AI434815 BQ708856 AI955702 AI088202 AF055585 AI379631 AW264567 BX509816 BQ015028 AA845944 BG484345 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SLIT2 (see all 8 ) About this scheme ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ SP1 : - - - - - - SP2 : - - - - - - - SP3 : - - - - - - SP4 : SP5 :
ExUns: 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42a · 42b SP1 : - - - SP2 : - - - SP3 : - - - SP4 : SP5 :
ECgene alternative splicing isoforms for SLIT2
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Expression for SLIT2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SLIT2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGGGACTAAT
About this image SLIT2 expression in embryonic tissues and stem cells About this table See SLIT2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SLIT2 SOURCE GeneReport for Unigene cluster: Hs.29802 UniProtKB/Swiss-Prot: SLIT2_HUMAN, O94813 Tissue specificity : Fetal lung and kidney, and adult spinal cord. Weak expression in adult adrenal gland, thyroid,trachea and other tissues examined SABiosciences Expression via Pathway-Focused PCR Arrays including SLIT2 : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLIT2
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Orthologsfor SLIT2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for SLIT2 gene from 6/22 species (see all 22 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves SLIT21
slit homolog 2 (Drosophila)
82.63(n) 93.57(a)
373967 XM_001232040.2 XP_001232041.1
lizard Reptilia SLIT26
--
92(a)
1 ↔ 1
5(75617983-75737578)
African clawed frog Amphibia AY046070.12
--
78.64(n)
AY046070.1
zebrafish Actinopterygii slit22
slit (Drosophila) homolog 2
74.37(n)
80353 AF210321.1
fruit fly Insecta sli1 3
axon guidance3 1
43(a) 3 52.08(n) 1 47.49(a) 1
36746 1 NM_057379.3 1 NP_476727.1 1
worm Secernentea slt-11
Protein SLT-1
48.44(n) 40.47(a)
181562 NM_078036.4 NP_510437.2
ENSEMBL Gene Tree for SLIT2 (if available)TreeFam Gene Tree for SLIT2 (if available)
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Paralogsfor SLIT2 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SLIT2 gene LRRC26 2 ISLR 2 LRIT2 2 LRRC17 2 SLIT1 2 LRRC52 2 LRTM1 2 LRIT1 2 LRTM2 2 ISLR2 2 LRIT3 2 LRRC55 2 SLIT3 2 LRRC24 2 LRRC38 2 18/41 SIMAP similar genes for SLIT2 using alignment to 7 protein entries: SLIT2_HUMAN (see all proteins )
(see all similar genes ):SLIT1 SLIT3 NOTCH3 F9 DCN PODN PODNL1 LINGO2 BGN LRRC15 ASPN FAT3 LINGO1 LGR6 LRRTM4 NGL1 CRB1 ISLR2 About GeneDecksing 1 Pseudogenes.org Pseudogene for SLIT2 PGOHUM00000245861
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Genomic Variantsfor SLIT2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 13 variations for SLIT2 11 CNVs 1667 10039 43239 63769 51359 4380 98646 37871 51361 91964 51360 2 Indels 40606 91965 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor SLIT2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 603746
OMIM disorders : --20/27 (see all 27 ): About MalaCards female breast cancer acute lymphocytic leukemia lymphocytic leukemia renal cell carcinoma squamous cell carcinoma pulmonary fibrosis pandas breast cancer colorectal cancer fibrosarcoma medulloblastoma fibrosis hepatocellular carcinoma cervical cancer cervicitis ovarian cancer pharyngitis nasopharyngitis carcinoma influenza 6 Novoseek disease relationships for SLIT2 gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
glioma
46.2
39
12881718 (9), 20008733 (7), 17968499 (5), 15534609 (2) (see all 5 )
colorectal carcinoma
31
1
12615722 (1)
cancer
23.4
9
14735202 (2), 18201275 (1), 18566128 (1), 20008733 (1) (see all 5 )
colorectal cancer
21.6
6
12615722 (4), 15534609 (1)
breast cancer
13.9
13
12384551 (6), 17268810 (2), 15534609 (1), 14735202 (1)
tumors
8.71
19
12384551 (6), 12615722 (3), 18201275 (2), 16685377 (2) (see all 5 )
Genetic Association Database (GAD): SLIT2 Human Genome Epidemiology (HuGE) Navigator: SLIT2 (17 documents) Export disorders for SLIT2 gene to outside databases
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Publicationsfor SLIT2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SLIT2 gene, integrated from 9 sources (see all 100 ):(articles sorted by number of sources associating them with SLIT2) Utopia : connect your pdf to the dynamic
Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. (PubMed id 9813312) 1 , 2 , 3(1998) Frequent epigenetic inactivation of the SLIT2 gene in gliomas. (PubMed id 12881718) 1 , 4, 9(2003) Slit2 is a repellent for retinal ganglion cell axons. (PubMed id 10864954) 1 , 2 , 9(2000) Structural insights into the Slit-Robo complex. (PubMed id 17848514) 1 , 2 , 9(2007) Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis. (PubMed id 10349621) 1 , 2 , 9(1998) Structure and functional relevance of the Slit2 homod imerization domain. (PubMed id 19498462) 1 , 2 (2009) Slits and their receptors. (PubMed id 18269211) 1 , 3(2007) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes. (PubMed id 12200164) 1 , 2 (2002) Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex. (PubMed id 11239147) 1 , 2 (2001)
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Specialized Databases showing SLIT2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for SLIT2 gene: SLIT2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SLIT2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for SLIT2 OriGene shRNA RFP for SLIT2 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for SLIT2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SLIT2 OriGene 3'-UTR Clone for SLIT2 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for SLIT2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SLIT2 OriGene Custom Protein Services for SLIT2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLIT2 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Search Tocris compounds for SLIT2
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLIT2
Search ThermoFisher Antibodies for SLIT2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLIT2
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and Proteopedia 
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BioSystems Pathway for SLIT2 
Kegg Pathway 
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Anatomical Compartment 
Negative
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