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SLIT1 Gene

protein-coding   GIFtS: 64
GCID: GC10M098747

Slit Homolog 1 (Drosophila)

(Previous name: slit (Drosophila) homolog 1)
(Previous symbol: SLIL1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Slit Homolog 1 (Drosophila)1 2     SLIT-12
SLIL11 2 3 5     SLIT32
MEGF42 3 5     Slit Homolog 1 Protein2
Multiple EGF-Like Domains Protein 42 3     KIAA08133
Multiple Epidermal Growth Factor-Like Domains Protein 42 3     Slit-13
Slit (Drosophila) Homolog 11     

External Ids:    HGNC: 110851   Entrez Gene: 65852   Ensembl: ENSG000001871227   OMIM: 6037425   UniProtKB: O750933   

Export aliases for SLIT1 gene to outside databases

Previous GC identifers: GC10M097651 GC10M097991 GC10M098889 GC10M098422 GC10M098425 GC10M092385


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLIT1 Gene:
SLIT1 (slit homolog 1 (Drosophila)) is a protein-coding gene. Diseases associated with SLIT1 include pharyngitis, and brain disease. GO annotations related to this gene include Roundabout binding and calcium ion binding. An important paralog of this gene is SLITRK5.

UniProtKB/Swiss-Prot: SLIT1_HUMAN, O75093
Function: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by
interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the
ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2
together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing
inappropriate midline crossing by axons projecting from the olfactory bulb

Gene Wiki entry for SLIT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLIT1 gene promoter:
         AREB6   NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLIT1 promoter sequence
   Search Chromatin IP Primers for SLIT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLIT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.3-q24   Ensembl cytogenetic band:  10q24.1   HGNC cytogenetic band: 10q23.3-q24

SLIT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLIT1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M098747:  view genomic region     (about GC identifiers)

Start:
98,757,795 bp from pter      End:
98,945,683 bp from pter
Size:
187,889 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SLIT1_HUMAN, O75093 (See protein sequence)
Recommended Name: Slit homolog 1 protein precursor  
Size: 1534 amino acids; 167926 Da
Subunit: Interacts with ROBO1 and GREM1 (By similarity)
Sequence caution: Sequence=BAA32465.3; Type=Erroneous initiation;
Secondary accessions: Q5T0V1 Q8WWZ2 Q9UIL7
Alternative splicing: 2 isoforms:  O75093-1   O75093-2   

Explore the universe of human proteins at neXtProt for SLIT1: NX_O75093

Explore proteomics data for SLIT1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn72, Asn192, Asn406, Asn571, Asn630, Asn762, Asn801, Asn806, Asn1026, Asn1079,
                                 Asn1189, Asn1259, Asn1306
  • Modification sites at PhosphoSitePlus

  • See SLIT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003052.2  
    ENSEMBL proteins: 
     ENSP00000266058   ENSP00000360109   ENSP00000315005   ENSP00000360080  
    Reactome Protein details: O75093

    SLIT1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SLIT1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SLIT1
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SLIT1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
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    Novus Biologicals SLIT1 Antibodies
    Search for Antibodies for SLIT1 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for SLIT1
    LSBio Antibodies in human, mouse, rat for SLIT1

    SLIT1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 16):
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR025875 Leu-rich_rpt_4
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp

    Graphical View of Domain Structure for InterPro Entry O75093

    ProtoNet protein and cluster: O75093

    Selected Blocks protein domains (see all 6):
    IPB000483 Cysteine-rich flanking region
    IPB001438 Type II EGF-like signature
    IPB001611 Leucine-rich repeat signature
    IPB001791 Laminin G
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: SLIT1_HUMAN, O75093
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 9 EGF-like domains
    Similarity: Contains 1 laminin G-like domain
    Similarity: Contains 20 LRR (leucine-rich) repeats
    Similarity: Contains 4 LRRCT domains
    Similarity: Contains 4 LRRNT domains


    SLIT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLIT1_HUMAN, O75093
    Function: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by
    interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the
    ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2
    together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing
    inappropriate midline crossing by axons projecting from the olfactory bulb

         Genatlas biochemistry entry for SLIT1:
    SLIT Drosophila homolog 1,expressed in the brain,ligand of GPC1,involved in histogenesis of central nervous system
    and in brain diseases

         Summary: 
    During embryonic development, SLIT1 as signaling molecule affects the following cells:
    Brain: Fetal Dopaminergic Neurons (Substantia Nigra pars Compacta), Fetal Dopaminergic Neurons (Ventral Tegmental Area)       to see all 2 cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding NAS9813312
    GO:0005515protein binding ----
    GO:0043395heparan sulfate proteoglycan binding IEA--
    GO:0048495Roundabout binding IPI15207848
         
    SLIT1 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slit1):
     cellular  mortality/aging  nervous system  no phenotypic analysis 

    SLIT1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLIT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLIT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLIT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLIT1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLIT1:
    hsa-mir-421 (MIRT039395)

    Block miRNA regulation of human, mouse, rat SLIT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLIT1 (see all 37):
    hsa-miR-142-5p hsa-miR-3607-3p hsa-miR-1276 hsa-miR-124 hsa-miR-3116 hsa-miR-23a hsa-miR-506 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidSLIT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLIT1
    Predesigned siRNA for gene silencing in human, mouse, rat SLIT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLIT1

    Clone
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    OriGene clones in human, mouse for SLIT1 (see all 6)
    OriGene ORF clones in mouse, rat for SLIT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLIT1 (NM_003061)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLIT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLIT1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SLIT1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLIT1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLIT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SLIT1_HUMAN, O75093: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol3
    plasma membrane3
    endoplasmic reticulum1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space NAS9813312
    GO:0005737cytoplasm ----

    SLIT1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLIT1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Cytoskeleton remodeling Slit Robo signaling0.92
    2L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    3Spinal Cord Injury
    Spinal Cord Injury
    4Signaling by Slit
    Signaling by Slit
    5Netrin-1 signaling
    Netrin-1 signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SLIT1
        Guidance Cues and Growth Cone Motility
    Signaling by Slit

    1 GeneGo (Thomson Reuters) Pathway for SLIT1
        Development Slit-Robo signaling

    1 BioSystems Pathway for SLIT1
        Spinal Cord Injury

    1 Reactome Pathway for SLIT1
        Netrin-1 signaling


    1 Kegg Pathway  (Kegg details for SLIT1):
        Axon guidance


    SLIT1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SLIT1: 
              Parkinson's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLIT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SLIT1 (O750932, 3 ENSP000002660584) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPC1P350523, ENSP000002640394I2D: score=1 STRING: ENSP00000264039
    ATN1P542593, ENSP000003490764I2D: score=2 STRING: ENSP00000349076
    ROBO1Q9Y6N73I2D: score=1 
    ROBO2ENSP000004171644STRING: ENSP00000417164
    LY86ENSP000002305684STRING: ENSP00000230568
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007409axonogenesis ----
    GO:0007411axon guidance TAS--
    GO:0007420brain development ----
    GO:0008045motor neuron axon guidance IMP16162649
    GO:0021510spinal cord development IEA--

    SLIT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLIT1

    1 PharmGKB related drug/compound annotation for SLIT1 gene    About this table
    Drug/compound PharmGKB Annotation
    etoposideCA  



    SLIT1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLIT1 gene: 
    NM_003061.2  

    Unigene Cluster for SLIT1:

    Slit homolog 1 (Drosophila)
    Hs.632082  [show with all ESTs]
    Unigene Representative Sequence: NM_003061
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266058(uc001kmw.2 uc009xvh.1) ENST00000494968 ENST00000371070
    ENST00000314867 ENST00000371041 ENST00000497714 ENST00000456008

    miRNA
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    Block miRNA regulation of human, mouse, rat SLIT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLIT1 (see all 37):
    hsa-miR-142-5p hsa-miR-3607-3p hsa-miR-1276 hsa-miR-124 hsa-miR-3116 hsa-miR-23a hsa-miR-506 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidSLIT1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SLIT1
    Predesigned siRNA for gene silencing in human, mouse, rat SLIT1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLIT1 (NM_003061)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLIT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLIT1
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLIT1
      QuantiTect SYBR Green Assays in human, mouse, rat SLIT1
      QuantiFast Probe-based Assays in human, mouse, rat SLIT1

    Additional mRNA sequence: 

    AB011537.3 AB017167.1 AK125438.1 AY029183.1 BC028105.1 BC146761.1 BC146851.1 

    9 DOTS entries:

    DT.423578  DT.100794661  DT.95163346  DT.101955788  DT.101964058  DT.70104136  DT.100705149  DT.100794666 
    DT.92421636 

    Selected AceView cDNA sequences (see all 73):

    BC028105 BM679102 AI362935 BM728969 NM_003061 AI216643 AB011537 AL043829 
    AI498825 AL134792 AB017167 AI869687 AI937520 CR617152 BM984983 AA351795 
    BM925712 BX478114 AI609730 AW027188 BX109409 BF346064 AY029183 AW149361 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLIT1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:                    -     -                                         -                                                   
    SP2:                                                              -     -                                                   
    SP3:                    -     -                                   -     -                                                   
    SP4:                    -     -     -     -     -     -           -     -                                                   
    SP5:                                                                          -                                             


    ECgene alternative splicing isoforms for SLIT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLIT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACATTGAGTC
    SLIT1 Expression
    About this image


    SLIT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Anterior astroglia-like cells
             Septum   
     
     Tooth (Integumentary System)    fully expand to see all 2 entries
             Inner Enamel Epithelial Cells Dental Enamel
     
     Epithelial Cells
             Inner Enamel Epithelial Cells Dental Enamel
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate
    SLIT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLIT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632082

    UniProtKB/Swiss-Prot: SLIT1_HUMAN, O75093
    Tissue specificity: Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including SLIT1: 
              Parkinson's Disease in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SLIT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLIT1
    QuantiTect SYBR Green Assays in human, mouse, rat SLIT1
    QuantiFast Probe-based Assays in human, mouse, rat SLIT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLIT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLIT1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slit11 , 5 slit homolog 1 (Drosophila)1, 5 89.22(n)1
    94.58(a)1
      19 (34.99 cM)5
    205621  NM_015748.31  NP_056563.21 
     416002575 
    chicken
    (Gallus gallus)
    Aves SLIT11 slit homolog 1 (Drosophila) 80.56(n)
    84.02(a)
      395293  NM_001277336.1  NP_001264265.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLIT16
    slit homolog 1 (Drosophila)
    84(a)
    1 ↔ 1
    GL343239.1(2026377-2206341)
    African clawed frog
    (Xenopus laevis)
    Amphibia slit1-prov2 slit homolog 1 (Drosophila) 77.03(n)    BC044982.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slit1a1 slit homolog 1a (Drosophila) 72.2(n)
    74.8(a)
      556123  NM_001034968.1  NP_001030140.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sli3 axon guidance 42(a)
    (best of 3)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea slt-16
    Protein SLT-1 (slt-1) mRNA, complete cds
    39(a)
    1 → many
    X(14674319-14683326) WBGene00004854


    ENSEMBL Gene Tree for SLIT1 (if available)
    TreeFam Gene Tree for SLIT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLIT1 gene
    SLITRK52  ISLR2  SLIT32  SLITRK62  LRRC382  SLIT22  LRRC262  SLITRK12  
    SLITRK42  LRTM12  LRRC522  LRRC172  SLITRK22  LRTM22  SLITRK32  LRRC552  
    ISLR22  LRRC242  
    6 SIMAP similar genes for SLIT1 using alignment to 6 protein entries:     SLIT1_HUMAN (see all proteins):
    SLIT2    SLIT3    F9    DCN    LRIG3    DLK1

    SLIT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLIT1 (see all 3213)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs741537411,2
    C,F--98757304(+) TCATCT/AGAATG 1 -- int12Minor allele frequency- A:0.06WA 120
    rs1141332731,2
    C,F--98757527(+) TACTTG/AAAGGG 1 -- int11Minor allele frequency- A:0.09WA 118
    rs1121993011,2
    C--98757542(+) AGGATG/-GAGCA 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs70811971,2
    C,F,H--98757563(+) CTCGGC/TCGTGC 1 -- int18Minor allele frequency- T:0.14NS EA WA CSA NA 660
    rs79056241,2
    C,F,H--98757564(+) TCGGCC/TGTGCA 1 -- int14Minor allele frequency- T:0.05NS EA WA 414
    rs1176315481,2
    F--98757584(+) CCCGGG/CGGGGT 1 -- int11Minor allele frequency- C:0.01NA 120
    rs1141487011,2
    C,F--98757823(+) CACATG/AGAAGA 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs1393284151,2
    C--98757879(+) GTGCAG/TCTCCC 1 -- ut310--------
    rs1819520231,2
    --98757884(+) GCTCCC/TTCATG 1 -- ut310--------
    rs1863447351,2
    --98757910(+) AGCCTA/CTAGGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SLIT1 (98757795 - 98945683 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SLIT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv995571CNV Deletion20482838
    esv1638639CNV Deletion17803354
    esv2739818CNV Deletion23290073
    esv2739807CNV Deletion23290073
    nsv7505CNV Insertion18451855
    nsv895913CNV Loss21882294
    nsv7506CNV Loss18451855
    nsv895912CNV Loss21882294
    nsv831951CNV Gain17160897
    essv12626CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLIT1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLIT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603742    OMIM disorders: --

    13 diseases for SLIT1:    
    About MalaCards
    pharyngitis    brain disease    spinal cord injury    cervical cancer
    parkinson's disease    cervicitis    retinitis    ataxia
    alzheimer's disease    obesity    hepatocellular carcinoma    neuronitis
    cerebritis


    SLIT1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for SLIT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0.0112 1 17146174 (1)
    cancer 0 3 15534609 (1), 18566128 (1)

    Genetic Association Database (GAD): SLIT1
    Human Genome Epidemiology (HuGE) Navigator: SLIT1 (9 documents)

    Export disorders for SLIT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLIT1 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with SLIT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. (PubMed id 9813312)1, 2, 3, 9 Itoh A.... Sakano S. (Brain Res. Mol. Brain Res. 1998)
    2. Identification of high-molecular-weight proteins with multiple EGF- like motifs by motif-trap screening. (PubMed id 9693030)1, 2, 3 Nakayama M.... Ohara O. (Genomics 1998)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    4. Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes. (PubMed id 12200164)1, 2 Wong K.... Rao Y. (Curr. Opin. Genet. Dev. 2002)
    5. Conserved modularity and potential for alternate splicing in mouse and human Slit genes. (PubMed id 12141424)1, 2 Little M.... Teasdale R.D. (Int. J. Dev. Biol. 2002)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    7. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    8. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium. (PubMed id 18829537)1 Marlow R....Hinck L. (Cancer Res. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6585 HGNC: 11085 AceView: SLIT1 Ensembl:ENSG00000187122 euGenes: HUgn6585
    ECgene: SLIT1 Kegg: 6585 H-InvDB: SLIT1

    (According to HUGE)
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    HUGE: KIAA0813

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLIT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLIT1 gene:
    Search GeneIP for patents involving SLIT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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