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Aliases for SLIT1 Gene

Aliases for SLIT1 Gene

  • Slit Guidance Ligand 1 2 3 5
  • Multiple Epidermal Growth Factor-Like Domains Protein 4 3 4
  • Multiple EGF-Like Domains Protein 4 3 4
  • SLIT-1 3 4
  • SLIL1 3 4
  • MEGF4 3 4
  • Slit (Drosophila) Homolog 1 2
  • Slit Homolog 1 (Drosophila) 2
  • Slit Homolog 1 3
  • KIAA0813 4
  • SLIT3 3

External Ids for SLIT1 Gene

Previous HGNC Symbols for SLIT1 Gene

  • SLIL1

Previous GeneCards Identifiers for SLIT1 Gene

  • GC10M097651
  • GC10M097991
  • GC10M098889
  • GC10M098422
  • GC10M098425
  • GC10M098747
  • GC10M092385

Summaries for SLIT1 Gene

GeneCards Summary for SLIT1 Gene

SLIT1 (Slit Guidance Ligand 1) is a Protein Coding gene. Diseases associated with SLIT1 include Diaphragm Disease. Among its related pathways are Axon guidance and Developmental Biology. GO annotations related to this gene include calcium ion binding and Roundabout binding. An important paralog of this gene is NOTCH2NL.

UniProtKB/Swiss-Prot for SLIT1 Gene

  • Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.

Gene Wiki entry for SLIT1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLIT1 Gene

Genomics for SLIT1 Gene

Regulatory Elements for SLIT1 Gene

Enhancers for SLIT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLIT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLIT1 Gene

Chromosome:
10
Start:
96,998,038 bp from pter
End:
97,185,926 bp from pter
Size:
187,889 bases
Orientation:
Minus strand

Genomic View for SLIT1 Gene

Genes around SLIT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLIT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLIT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLIT1 Gene

Proteins for SLIT1 Gene

  • Protein details for SLIT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75093-SLIT1_HUMAN
    Recommended name:
    Slit homolog 1 protein
    Protein Accession:
    O75093
    Secondary Accessions:
    • Q5T0V1
    • Q8WWZ2
    • Q9UIL7

    Protein attributes for SLIT1 Gene

    Size:
    1534 amino acids
    Molecular mass:
    167926 Da
    Quaternary structure:
    • Interacts with ROBO1 and GREM1.
    SequenceCaution:
    • Sequence=BAA32465.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLIT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLIT1 Gene

Proteomics data for SLIT1 Gene at MOPED

Post-translational modifications for SLIT1 Gene

  • Glycosylation at Asn 72, Asn 192, Asn 406, Asn 571, Asn 630, Asn 762, Asn 801, Asn 806, Asn 1026, Asn 1079, Asn 1189, Asn 1259, and Asn 1306
  • Modification sites at PhosphoSitePlus

Other Protein References for SLIT1 Gene

No data available for DME Specific Peptides for SLIT1 Gene

Domains & Families for SLIT1 Gene

Graphical View of Domain Structure for InterPro Entry

O75093

UniProtKB/Swiss-Prot:

SLIT1_HUMAN :
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 20 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 9 EGF-like domains.
  • Contains 1 laminin G-like domain.
  • Contains 4 LRRCT domains.
  • Contains 4 LRRNT domains.
Similarity:
  • Contains 20 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with SLIT1: view

No data available for Gene Families for SLIT1 Gene

Function for SLIT1 Gene

Molecular function for SLIT1 Gene

GENATLAS Biochemistry:
SLIT Drosophila homolog 1,expressed in the brain,ligand of GPC1,involved in histogenesis of central nervous system and in brain diseases
UniProtKB/Swiss-Prot Function:
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.

LifeMap Function Summary for SLIT1 Gene

genes like me logo Genes that share phenotypes with SLIT1: view

Animal Models for SLIT1 Gene

MGI Knock Outs for SLIT1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLIT1 Gene

Localization for SLIT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLIT1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLIT1 Gene COMPARTMENTS Subcellular localization image for SLIT1 gene
Compartment Confidence
extracellular 5
plasma membrane 3
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SLIT1 Gene

Pathways & Interactions for SLIT1 Gene

genes like me logo Genes that share pathways with SLIT1: view

Pathways by source for SLIT1 Gene

1 BioSystems pathway for SLIT1 Gene
3 Reactome pathways for SLIT1 Gene
1 KEGG pathway for SLIT1 Gene
1 GeneGo (Thomson Reuters) pathway for SLIT1 Gene

SIGNOR curated interactions for SLIT1 Gene

Activates:

Gene Ontology (GO) - Biological Process for SLIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007409 axonogenesis IEA --
GO:0008045 motor neuron axon guidance IMP 16162649
GO:0021772 olfactory bulb development IEA --
GO:0021834 NOT chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration IDA 11748139
GO:0022029 telencephalon cell migration IEA --
genes like me logo Genes that share ontologies with SLIT1: view

Drugs & Compounds for SLIT1 Gene

(2) Drugs for SLIT1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Etoposide Approved Pharma Topo II inhibitor, Topoisomerase 2 Inhibitors, Topoisomerase II inhibitor 1189
Hydrochlorothiazide Approved Pharma Inhibition, Inhibitor 396
genes like me logo Genes that share compounds with SLIT1: view

Transcripts for SLIT1 Gene

Unigene Clusters for SLIT1 Gene

Slit homolog 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLIT1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - - - - - -
SP5: -
SP6: -
SP7: -

Relevant External Links for SLIT1 Gene

GeneLoc Exon Structure for
SLIT1
ECgene alternative splicing isoforms for
SLIT1

Expression for SLIT1 Gene

mRNA expression in normal human tissues for SLIT1 Gene

mRNA differential expression in normal tissues according to GTEx for SLIT1 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x7.3), Brain - Nucleus accumbens (basal ganglia) (x5.7), Brain - Frontal Cortex (BA9) (x5.2), Brain - Caudate (basal ganglia) (x5.0), Pituitary (x4.7), Brain - Hippocampus (x4.5), Brain - Cortex (x4.2), and Brain - Amygdala (x4.0).

Protein differential expression in normal tissues from HIPED for SLIT1 Gene

This gene is overexpressed in Vitreous humor (20.8), Bone (14.5), Urine (9.3), and Cerebrospinal fluid (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLIT1 Gene



SOURCE GeneReport for Unigene cluster for SLIT1 Gene Hs.632082

mRNA Expression by UniProt/SwissProt for SLIT1 Gene

O75093-SLIT1_HUMAN
Tissue specificity: Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney.
genes like me logo Genes that share expression patterns with SLIT1: view

Primer Products

No data available for Protein tissue co-expression partners for SLIT1 Gene

Orthologs for SLIT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLIT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLIT1 35
  • 90.79 (n)
  • 93.94 (a)
SLIT1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLIT1 35
  • 91.16 (n)
  • 94.59 (a)
SLIT1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slit1 35
  • 89.22 (n)
  • 94.58 (a)
Slit1 16
Slit1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLIT1 35
  • 99.56 (n)
  • 99.87 (a)
rat
(Rattus norvegicus)
Mammalia Slit1 35
  • 89.16 (n)
  • 94.51 (a)
oppossum
(Monodelphis domestica)
Mammalia SLIT1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLIT1 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLIT1 35
  • 80.56 (n)
  • 84.02 (a)
lizard
(Anolis carolinensis)
Reptilia SLIT1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slit1 35
  • 75.07 (n)
  • 83.87 (a)
African clawed frog
(Xenopus laevis)
Amphibia slit1-prov 35
zebrafish
(Danio rerio)
Actinopterygii slit1a 35
  • 72.2 (n)
  • 74.8 (a)
slit1a 36
  • 74 (a)
OneToMany
slit1b 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG15388 37
  • 41 (a)
CG5195 37
  • 24 (a)
sli 37
  • 42 (a)
sli 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea slt-1 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
ManyToMany
Species with no ortholog for SLIT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLIT1 Gene

ENSEMBL:
Gene Tree for SLIT1 (if available)
TreeFam:
Gene Tree for SLIT1 (if available)

Paralogs for SLIT1 Gene

Paralogs for SLIT1 Gene

(6) SIMAP similar genes for SLIT1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLIT1: view

Variants for SLIT1 Gene

Sequence variations from dbSNP and Humsavar for SLIT1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2817673 - 97,031,645(-) CATCC(C/T)GCCTT reference, missense
rs1490692 -- 97,107,253(+) TGAGG(C/T)TGGAT intron-variant
rs1490693 -- 97,107,458(+) GCATC(C/T)TAACT intron-variant
rs1490694 -- 97,107,482(+) CCCCA(A/G)AGCTC intron-variant
rs1490695 -- 97,107,537(+) TTCCT(A/G)TTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLIT1 Gene

Variant ID Type Subtype PubMed ID
nsv831951 CNV Gain 17160897
essv12626 CNV CNV 17122850
nsv895912 CNV Loss 21882294
nsv7505 CNV Insertion 18451855
esv2739807 CNV Deletion 23290073
esv995571 CNV Deletion 20482838
nsv895913 CNV Loss 21882294
esv2739818 CNV Deletion 23290073
esv1638639 CNV Deletion 17803354
nsv7506 CNV Loss 18451855

Variation tolerance for SLIT1 Gene

Residual Variation Intolerance Score: 3.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.62; 56.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLIT1 Gene

Disorders for SLIT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLIT1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
diaphragm disease
  • disease of diaphragm
- elite association - COSMIC cancer census association via MalaCards
Search SLIT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SLIT1

Genetic Association Database (GAD)
SLIT1
Human Genome Epidemiology (HuGE) Navigator
SLIT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLIT1
genes like me logo Genes that share disorders with SLIT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLIT1 Gene

Publications for SLIT1 Gene

  1. Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. (PMID: 9813312) Itoh A. … Sakano S. (Brain Res. Mol. Brain Res. 1998) 2 3 4 23 67
  2. Identification of high-molecular-weight proteins with multiple EGF- like motifs by motif-trap screening. (PMID: 9693030) Nakayama M. … Ohara O. (Genomics 1998) 2 3
  3. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3
  4. Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. (PMID: 24376456) Simino J. … Rao D.C. (Front Genet 2013) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for SLIT1 Gene

Sources for SLIT1 Gene

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