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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLIT1 Gene

protein-coding   GIFtS: 63
GCID: GC10M098747

slit homolog 1 (Drosophila)

(Previous name: slit (Drosophila) homolog 1 )
(Previous symbol: SLIL1)
 Explore 10 diseases affiliated with
SLIT1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLIT1    

Aliases
for SLIT1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Slit Homolog 1 (Drosophila)1 2     Multiple Epidermal Growth Factor-Like Domains Protein 42 3
MEGF41 2 3     Slit (Drosophila) Homolog 11
SLIL11 2 3     Slit11
SLIT31 2     SLIT-12
Slit-11 3     Slit Homolog 1 Protein2
Multiple EGF-Like Domains Protein 42 3     KIAA08133

External Ids:    HGNC: 110851   Entrez Gene: 65852   Ensembl: ENSG000001871227   OMIM: 6037425   UniProtKB: O750933   

Export aliases for SLIT1 gene to outside databases

Previous GC identifers: GC10M097651 GC10M097991 GC10M098889 GC10M098422 GC10M098425 GC10M092385


Summaries
for SLIT1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SLIT1_HUMAN, O75093
Function: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by
interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral
midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem
to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline
crossing by axons projecting from the olfactory bulb

Gene Wiki entry for SLIT1


Genomic Views
for SLIT1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLIT1 gene promoter:
         AREB6   NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLIT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLIT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLIT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.3-q24   Ensembl cytogenetic band:  10q24.1   HGNC cytogenetic band: 10q23.3-q24

SLIT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLIT1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M098747:  view genomic region     (about GC identifiers)

Start:
 98,757,795 bp from pter      End:
 98,945,683 bp from pter
Size:
 187,889 bases      Orientation:
 minus strand

Proteins
for SLIT1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SLIT1_HUMAN, O75093 (See protein sequence)
Recommended Name: Slit homolog 1 protein precursor  
Size: 1534 amino acids; 167926 Da
Subunit: Interacts with ROBO1 and GREM1 (By similarity)
Subcellular location: Secreted (By similarity)
Sequence caution: Sequence=BAA32465.3; Type=Erroneous initiation;
Secondary accessions: Q5T0V1 Q8WWZ2 Q9UIL7
Alternative splicing: 2 isoforms:  O75093-1   O75093-2   

Explore the universe of human proteins at neXtProt for SLIT1: NX_O75093

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75093

    • SLIT1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003052.2  
    ENSEMBL proteins: 
     ENSP00000266058   ENSP00000360109   ENSP00000315005   ENSP00000405183   ENSP00000360080  
    Reactome Protein details: O75093
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SLIT1
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SLIT1
    OriGene Custom Protein Services for SLIT1 
    GenScript Custom Purified and Recombinant Proteins Services for SLIT1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space NAS9813312
    GO:0005737cytoplasm IDA--


    SLIT1 for ontologies           About GeneDecksing



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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for SLIT1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLIT1 for domains           About GeneDecksing

    5/15 InterPro domains/families (see all 15):
     IPR000483 Cys-rich_flank_reg_C
     IPR000372 LRR-contain_N
     IPR001881 EGF-like_Ca-bd
     IPR001611 Leu-rich_rpt
     IPR025875 Leu-rich_rpt_4

    Graphical View of Domain Structure for InterPro Entry O75093

    ProtoNet protein and cluster: O75093

    5/6 Blocks protein families (see all 6):
    IPB000483 Cysteine-rich flanking region
    IPB001438 Type II EGF-like signature
    IPB001611 Leucine-rich repeat signature
    IPB001791 Laminin G
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: SLIT1_HUMAN, O75093
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 9 EGF-like domains
    Similarity: Contains 1 laminin G-like domain
    Similarity: Contains 20 LRR (leucine-rich) repeats
    Similarity: Contains 4 LRRCT domains
    Similarity: Contains 4 LRRNT domains


    Function
    for SLIT1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SLIT1_HUMAN, O75093
    Function: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by
    interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral
    midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem
    to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline
    crossing by axons projecting from the olfactory bulb

         Genatlas biochemistry entry for SLIT1:
    SLIT Drosophila homolog 1,expressed in the brain,ligand of GPC1,involved in histogenesis of central nervous system and
    in brain diseases

         Summary:  
    During embryonic development, SLIT1 as signaling molecule
    affects the following cells: Embryonic Dopaminergic Neurons in Substantia Nigra pars Compacta, Embryonic Dopaminergic Neurons in Ventral Tegmental Area

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLIT1
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate SLIT1 (see all 37):
    hsa-miR-142-5p hsa-miR-3607-3p hsa-miR-1276 hsa-miR-124 hsa-miR-3116 hsa-miR-23a hsa-miR-506 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmid: SLIT1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLIT1 (see all 7)
    OriGene shRNA RFP: SLIT1
    OriGene siRNA: SLIT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLIT1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SLIT1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLIT1 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: SLIT1 (NM_003061)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLIT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLIT1 

    Cell Line
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    Search LifeMap BioReagents cell lines for SLIT1

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLIT1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding NAS9813312
    GO:0043395heparan sulfate proteoglycan binding IEA--
    GO:0048495Roundabout binding IPI15207848


    SLIT1 for ontologies           About GeneDecksing


    Animal Models:
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Slit1):
     cellular  mortality/aging  nervous system  no phenotypic analysis 

    SLIT1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLIT1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    		Axon guidance1.00
    		Developmental Biology0.69
    2Cytoskeleton remodeling Slit-Robo signaling
    		Cytoskeleton remodeling Slit-Robo signaling1.00
    		Development_Slit-Robo signaling0.92
    3Signaling by Slit
    		Signaling by Slit1.00
    4Guidance Cues and Growth Cone Motility
    		Guidance Cues and Growth Cone Motility1.00
    5Axon guidance
    		Axon guidance1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SLIT1
        Cytoskeleton remodeling Slit-Robo signaling

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SLIT1
        Guidance Cues and Growth Cone Motility
    Signaling by Slit

    1 GeneGo (Thomson Reuters) Pathway for SLIT1
        Development Slit-Robo signaling

    3        Reactome Pathways for SLIT1
        Developmental Biology
    Netrin-1 signaling
    Axon guidance


    1         Kegg Pathway  (Kegg details for SLIT1):
        Axon guidance


    SLIT1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLIT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for SLIT1 (O750932, 3 ENSP000002660584) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPC1P350523, ENSP000002640394I2D: score=1 STRING: ENSP00000264039
    ATN1P542593, ENSP000003490764I2D: score=2 STRING: ENSP00000349076
    ROBO1Q9Y6N73I2D: score=1 
    LY86ENSP000002305684STRING: ENSP00000230568
    ROBO2ENSP000004171644STRING: ENSP00000417164
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007409axonogenesis ----
    GO:0007411axon guidance TAS--
    GO:0007420brain development ----
    GO:0008045motor neuron axon guidance IMP16162649
    GO:0021510spinal cord development IEA--


    SLIT1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLIT1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLIT1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLIT1
    1 PharmGKB related drug/compound annotation for SLIT1 gene
    Drug/compound PharmGKB Annotation
    etoposideCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about SLIT1 

    Transcripts
    for SLIT1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLIT1 gene: 
    NM_003061.2  

    Unigene Cluster for SLIT1:

    Slit homolog 1 (Drosophila)
    Hs.632082  [show with all ESTs]
    Unigene Representative Sequence: NM_003061
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266058(uc001kmw.2 uc009xvh.1) ENST00000494968 ENST00000371070
    ENST00000314867 ENST00000456008 ENST00000371041 ENST00000497714 ENST00000475285


    miRNA
    Products:             		 OriGene 3'-UTR Clone: SLIT1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLIT1
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate SLIT1 (see all 37):
    hsa-miR-142-5p hsa-miR-3607-3p hsa-miR-1276 hsa-miR-124 hsa-miR-3116 hsa-miR-23a hsa-miR-506 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmid: SLIT1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLIT1 (see all 7)
    OriGene shRNA RFP: SLIT1
    OriGene siRNA: SLIT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLIT1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLIT1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLIT1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SLIT1 (NM_003061)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLIT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLIT1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLIT1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLIT1

    Additional cDNA sequence: 

    AB011537.3 AB017167.1 AK125438.1 AY029183.1 BC028105.1 BC146761.1 BC146851.1 

    10 DOTS entries:

    DT.423578  DT.100794661  DT.95163346  DT.101955788  DT.101964058  DT.70104136  DT.100705149  DT.100794666 
    DT.92421636  DT.40258982 

    24/73 AceView cDNA sequences (see all 73):

    CR617152 AL134792 BM679102 AB017167 BC028105 AI869687 NM_003061 BM984983 
    AI362935 AI216643 AI937520 AB011537 BM728969 AL043829 AI498825 BI914579 
    BI918214 AW027188 BM925712 BM728946 CD671648 AI609730 BF346064 AA488181 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SLIT1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:                    -     -                                         -                                                   
    SP2:                                                              -     -                                                   
    SP3:                    -     -                                   -     -                                                   
    SP4:                    -     -     -     -     -     -           -     -                                                   
    SP5:                                                                          -                                             


    ECgene alternative splicing isoforms for SLIT1

    Expression
    for SLIT1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLIT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACATTGAGTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLIT1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainHypothalamusBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLIT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLIT1

    SOURCE GeneReport for Unigene cluster: Hs.632082

    UniProtKB/Swiss-Prot: SLIT1_HUMAN, O75093
    Tissue specificity: Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney

        SABiosciences Expression via Pathway-Focused PCR Array including SLIT1: 
              Parkinson's Disease in human mouse rat

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLIT1

    Orthologs
    for SLIT1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLIT1 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLIT11 slit homolog 1 (Drosophila) 80.5(n)
    83.89(a)    		   395293  XM_421715.3  XP_421715.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SLIT16
    		 --
    		 84(a)
    		 1 ↔ 1
    		 GL343239.1(2026377-2067073)
    African clawed frog
    (Xenopus laevis)    		 Amphibia slit1-prov2 slit homolog 1 (Drosophila) 77.03(n)    BC044982.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii slit1a1 slit homolog 1a (Drosophila) 72.01(n)
    74.5(a)    		   556123  NM_001034968.1  NP_001030140.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta sli3 axon guidance 42(a)
    (best of 3)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea glp-16
    lin-126
    (see all 5)    		 Protein lin-12
    (see all 5)    		 9(a)
    8(a)
    (see all 5)    		 possible ortholog
    possible ortholog
    (see all 5)    		 III(9092164-9099606)
    III(9060165-9071683)


    ENSEMBL Gene Tree for SLIT1 (if available)
    TreeFam Gene Tree for SLIT1 (if available) 

    Paralogs
    for SLIT1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLIT1 gene
    LRRC262  SLIT22  ISLR2  LRIT22  LRRC172  LRRC522  LRTM12  LRIT12  
    LRTM22  ISLR22  LRIT32  LRRC552  SLIT32  LRRC242  LRRC382  
    7 SIMAP similar genes for SLIT1 using alignment to 6 protein entries:     SLIT1_HUMAN (see all proteins):
    SLIT2    SLIT3    F9    DCN    LRIG3    DLK1
    NOTCH2NL

    SLIT1 for paralogs           About GeneDecksing



    Genomic Variants
    for SLIT1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3334 NCBI SNPs in SLIT1 are shown (see all 3334)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs741537411,2
    		C,--98757304(+) TCATCT/AGAATG 1 -- int12Minor allele frequency- A:0.06WA 120
    rs1141332731,2
    		C,F,--98757527(+) TACTTG/AAAGGG 1 -- int11Minor allele frequency- A:0.09WA 118
    rs1121993011,2
    		C,--98757542(+) AGGATG/-GAGCA 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs70811971,2
    		C,F,H,--98757563(+) CTCGGC/TCGTGC 1 -- int18Minor allele frequency- T:0.14NS EA WA CSA NA 660
    rs79056241,2
    		C,H,--98757564(+) TCGGCC/TGTGCA 1 -- int14Minor allele frequency- T:0.05NS EA WA 414
    rs1176315481,2
    		--98757584(+) CCCGGG/CGGGGT 1 -- int11Minor allele frequency- C:0.01NA 120
    rs1141487011,2
    		F,--98757823(+) CACATG/AGAAGA 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs1393284151,2
    		--98757879(+) GTGCAG/TCTCCC 1 -- ut310--------
    rs1819520231,2
    		--98757884(+) GCTCCC/TTCATG 1 -- ut310--------
    rs1863447351,2
    		--98757910(+) AGCCTA/CTAGGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SLIT1 (98757795 - 98945683 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SLIT1
         1 CNV: 3817
         1 Indel: 39777

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    Disorders / Diseases
    for SLIT1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLIT1 for disorders           About GeneDecksing

    OMIM gene information: 603742    OMIM disorders: --

    10 diseases for SLIT1:    About MalaCards
    brain disease    parkinson's disease    cervical cancer    alzheimer's disease
    cervicitis    pharyngitis    ataxia    retinitis
    neuronitis    carcinoma

    2 Novoseek disease relationships for SLIT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0.0112 1 17146174 (1)
    cancer 0 3 15534609 (1), 18566128 (1)

    Human Genome Epidemiology (HuGE) Navigator: SLIT1 (9 documents)

    Export disorders for SLIT1 gene to outside databases

    Publications
    for SLIT1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLIT1 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with SLIT1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. (PubMed id 9813312)1, 2, 3, 9 Itoh A.... Sakano S. (1998)
    2. Identification of high-molecular-weight proteins with multiple EGF- like motifs by motif-trap screening. (PubMed id 9693030)1, 2, 3 Nakayama M.... Ohara O. (1998)
    3. Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes. (PubMed id 12200164)1, 2 Wong K.... Rao Y. (2002)
    4. Conserved modularity and potential for alternate splicing in mouse and human Slit genes. (PubMed id 12141424)1, 2 Little M.... Teasdale R.D. (2002)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    7. SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium. (PubMed id 18829537)1 Marlow R....Hinck L. (2008)
    8. A molecular mechanism for the heparan sulfate dependence of slit-robo signaling. (PubMed id 17062560)1 Hussain S.A....Hohenester E. (2006)
    9. Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits. (PubMed id 16840550)1 Lin L. and Isacson O. (2006)
    10. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)

    External Searches for SLIT1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing SLIT1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6585 HGNC: 11085 AceView: SLIT1 Ensembl:ENSG00000187122 euGenes: HUgn6585
    ECgene: SLIT1 Kegg: 6585 H-InvDB: SLIT1

    Other Databases showing SLIT1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0813

    Specialized Databases showing SLIT1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLIT1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLIT1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLIT1 gene:
    Search GeneIP for patents involving SLIT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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