Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLIRP Gene

Aliases for SLIRP Gene

  • SRA Stem-Loop Interacting RNA Binding Protein 2 3 5
  • C14orf156 3 4
  • Chromosome 14 Open Reading Frame 156 2
  • PD04872 3
  • DC50 3

External Ids for SLIRP Gene

Previous HGNC Symbols for SLIRP Gene

  • C14orf156

Previous GeneCards Identifiers for SLIRP Gene

  • GC14P078175

Summaries for SLIRP Gene

Entrez Gene Summary for SLIRP Gene

  • Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 [PubMed 16762838]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLIRP Gene

SLIRP (SRA Stem-Loop Interacting RNA Binding Protein) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding.

UniProtKB/Swiss-Prot for SLIRP Gene

  • RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLIRP Gene

Genomics for SLIRP Gene

Regulatory Elements for SLIRP Gene

Enhancers for SLIRP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLIRP on UCSC Golden Path with GeneCards custom track

Promoters for SLIRP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLIRP on UCSC Golden Path with GeneCards custom track

Genomic Location for SLIRP Gene

Chromosome:
14
Start:
77,708,071 bp from pter
End:
77,761,104 bp from pter
Size:
53,034 bases
Orientation:
Plus strand

Genomic View for SLIRP Gene

Genes around SLIRP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLIRP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLIRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLIRP Gene

Proteins for SLIRP Gene

  • Protein details for SLIRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZT3-SLIRP_HUMAN
    Recommended name:
    SRA stem-loop-interacting RNA-binding protein, mitochondrial
    Protein Accession:
    Q9GZT3
    Secondary Accessions:
    • J3KMY7

    Protein attributes for SLIRP Gene

    Size:
    109 amino acids
    Molecular mass:
    12349 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLIRP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLIRP Gene

Proteomics data for SLIRP Gene at MOPED

Post-translational modifications for SLIRP Gene

  • Ubiquitination at Lys 36 and Lys 88
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLIRP Gene

Domains & Families for SLIRP Gene

Gene Families for SLIRP Gene

Protein Domains for SLIRP Gene

Suggested Antigen Peptide Sequences for SLIRP Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZT3

UniProtKB/Swiss-Prot:

SLIRP_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with SLIRP: view

Function for SLIRP Gene

Molecular function for SLIRP Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation.

Gene Ontology (GO) - Molecular Function for SLIRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with SLIRP: view
genes like me logo Genes that share phenotypes with SLIRP: view

Animal Models for SLIRP Gene

MGI Knock Outs for SLIRP:

Animal Model Products

CRISPR Products

miRNA for SLIRP Gene

miRTarBase miRNAs that target SLIRP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLIRP Gene

Localization for SLIRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLIRP Gene

Mitochondrion. Nucleus. Note=Predominantly mitochondrial. Some fraction is nuclear. In the nucleus, it is recruited to nuclear receptor target promoters.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLIRP Gene COMPARTMENTS Subcellular localization image for SLIRP gene
Compartment Confidence
mitochondrion 5
nucleus 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for SLIRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IDA 20833797
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with SLIRP: view

Pathways & Interactions for SLIRP Gene

SuperPathways for SLIRP Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLIRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030317 sperm motility IEA --
genes like me logo Genes that share ontologies with SLIRP: view

No data available for Pathways by source and SIGNOR curated interactions for SLIRP Gene

Drugs & Compounds for SLIRP Gene

No Compound Related Data Available

Transcripts for SLIRP Gene

Unigene Clusters for SLIRP Gene

SRA stem-loop interacting RNA binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLIRP Gene

No ASD Table

Relevant External Links for SLIRP Gene

GeneLoc Exon Structure for
SLIRP
ECgene alternative splicing isoforms for
SLIRP

Expression for SLIRP Gene

mRNA expression in normal human tissues for SLIRP Gene

Protein differential expression in normal tissues from HIPED for SLIRP Gene

This gene is overexpressed in Bone (26.2) and Nasal epithelium (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLIRP Gene



SOURCE GeneReport for Unigene cluster for SLIRP Gene Hs.655105

mRNA Expression by UniProt/SwissProt for SLIRP Gene

Q9GZT3-SLIRP_HUMAN
Tissue specificity: Ubiquitously expressed, with highest level in heart, liver, skeletal muscle and testis.
genes like me logo Genes that share expression patterns with SLIRP: view

Protein tissue co-expression partners for SLIRP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SLIRP Gene

Orthologs for SLIRP Gene

This gene was present in the common ancestor of animals.

Orthologs for SLIRP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLIRP 35
  • 81.35 (n)
  • 73.39 (a)
-- 36
  • 44 (a)
OneToMany
SLIRP 36
  • 72 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SLIRP 35
  • 82.11 (n)
  • 74.74 (a)
SLIRP 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slirp 35
  • 82.25 (n)
  • 72.83 (a)
Slirp 16
Slirp 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLIRP 35
  • 99.69 (n)
  • 100 (a)
SLIRP 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slirp 35
  • 82.25 (n)
  • 72.83 (a)
oppossum
(Monodelphis domestica)
Mammalia SLIRP 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLIRP 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLIRP 35
  • 60.95 (n)
  • 52.86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slirp 35
  • 63.89 (n)
  • 62.5 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-276n11.1 35
  • 67.12 (n)
  • 59.46 (a)
SLIRP 36
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG33714 36
  • 31 (a)
OneToMany
CG8021 36
  • 29 (a)
OneToMany
Species with no ortholog for SLIRP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLIRP Gene

ENSEMBL:
Gene Tree for SLIRP (if available)
TreeFam:
Gene Tree for SLIRP (if available)

Paralogs for SLIRP Gene

Pseudogenes.org Pseudogenes for SLIRP Gene

genes like me logo Genes that share paralogs with SLIRP: view

No data available for Paralogs for SLIRP Gene

Variants for SLIRP Gene

Sequence variations from dbSNP and Humsavar for SLIRP Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs176945 -- 77,711,310(+) TTGTT(C/G)AAAAA intron-variant
rs176946 -- 77,712,096(+) caagc(A/G)taatg intron-variant
rs176947 -- 77,712,604(+) tacgc(C/T)cggct intron-variant
rs176948 -- 77,712,761(+) tttaa(C/T)tgtag intron-variant
rs176949 -- 77,712,849(+) tgtta(A/C)ctagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLIRP Gene

Variant ID Type Subtype PubMed ID
dgv643e1 CNV Complex 17122850
essv7944 CNV CNV 17122850
esv34940 CNV Gain 17911159
nsv521287 CNV Gain 19592680
nsv520021 CNV Gain 19592680

Variation tolerance for SLIRP Gene

Residual Variation Intolerance Score: 80.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLIRP Gene

HapMap Linkage Disequilibrium report
SLIRP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLIRP Gene

Disorders for SLIRP Gene

Relevant External Links for SLIRP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLIRP

No disorders were found for SLIRP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLIRP Gene

Publications for SLIRP Gene

  1. SLIRP, a small SRA binding protein, is a nuclear receptor corepressor. (PMID: 16762838) Hatchell E.C. … Leedman P.J. (Mol. Cell 2006) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for SLIRP Gene

Sources for SLIRP Gene

Content