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SLIRP Gene

protein-coding   GIFtS: 47
GCID: GC14P078175

SRA Stem-Loop Interacting RNA Binding Protein

(Previous name: chromosome 14 open reading frame 156)
(Previous symbol: C14orf156)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SRA Stem-Loop Interacting RNA Binding Protein1 2
C14orf1561 2 3 5
Chromosome 14 Open Reading Frame 1561
DC502
PD048722
SRA Stem-Loop-Interacting RNA-Binding Protein, Mitochondrial2

External Ids:    HGNC: 204951   Entrez Gene: 818922   Ensembl: ENSG000001197057   OMIM: 6102115   UniProtKB: Q9GZT33   

Export aliases for SLIRP gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLIRP Gene:
Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable
stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop
structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 (PubMed
16762838)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLIRP Gene:
SLIRP (SRA stem-loop interacting RNA binding protein) is a protein-coding gene. GO annotations related to this gene include RNA binding and nucleotide binding.

UniProtKB/Swiss-Prot: SLIRP_HUMAN, Q9GZT3
Function: RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA,
and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to
repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SLIRP
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLIRP promoter sequence
   Search Chromatin IP Primers for SLIRP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLIRP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

SLIRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLIRP gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P078175:  view genomic region     (about GC identifiers)

Start:
78,174,414 bp from pter      End:
78,227,447 bp from pter
Size:
53,034 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SLIRP_HUMAN, Q9GZT3 (See protein sequence)
Recommended Name: SRA stem-loop-interacting RNA-binding protein, mitochondrial precursor  
Size: 109 amino acids; 12349 Da
Secondary accessions: J3KMY7
Alternative splicing: 2 isoforms:  Q9GZT3-1   Q9GZT3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLIRP: NX_Q9GZT3

Explore proteomics data for SLIRP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys36, Lys88
  • Modification sites at PhosphoSitePlus

  • See SLIRP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001254792.1  NP_001254793.1  NP_112487.1  

    ENSEMBL proteins: 
     ENSP00000450909   ENSP00000238688   ENSP00000452057   ENSP00000450849   ENSP00000451606  
     ENSP00000450770   ENSP00000452162   ENSP00000452329   ENSP00000450587  

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    Search eBioscience for ELISAs for SLIRP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q9GZT3

    ProtoNet protein and cluster: Q9GZT3

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SLIRP_HUMAN, Q9GZT3
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with SLIRP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLIRP_HUMAN, Q9GZT3
    Function: RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA,
    and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to
    repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SLIRP           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slirp):
     mortality/aging  no phenotypic analysis  reproductive system 

    Find genes that share phenotypes with SLIRP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slirptm1.2Pjle for SLIRP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLIRP
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLIRP

    miRNA
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    hsa-mir-1914-5p (MIRT035796), hsa-mir-16-5p (MIRT031680)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SLIRP_HUMAN, Q9GZT3: Mitochondrion. Nucleus. Note=Predominantly mitochondrial. Some fraction is nuclear. In the
    nucleus, it is recruited to nuclear receptor target promoters

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IDA--
    GO:0030529ribonucleoprotein complex IEA--

    Find genes that share ontologies with SLIRP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLIRP
    Interactions:

        Search GeneGlobe Interaction Network for SLIRP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SLIRP (Q9GZT32, 3 ENSP000002386884) via UniProtKB, MINT, STRING, and/or I2D (see all 282)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRPPRCP427042, ENSP000002606654MINT-8340644 MINT-8079030 STRING: ENSP00000260665
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    SLX1AQ9BQ833, ENSP000002513034I2D: score=2 STRING: ENSP00000251303
    SLX1BQ9BQ833, ENSP000003289404I2D: score=2 STRING: ENSP00000328940
    BABAM1Q9NWV83, ENSP000003524084I2D: score=2 STRING: ENSP00000352408
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    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000961negative regulation of mitochondrial RNA catabolic process IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with SLIRP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLIRP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLIRP gene (3 alternative transcripts): 
    NM_001267863.1  NM_001267864.1  NM_031210.5  

    Unigene Cluster for SLIRP:

    SRA stem-loop interacting RNA binding protein
    Hs.655105  [show with all ESTs]
    Unigene Representative Sequence: BQ278491
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000557342(uc001xue.4) ENST00000238688 ENST00000557623 ENST00000557431
    ENST00000555890 ENST00000556831 ENST00000554074 ENST00000556375 ENST00000556310
    ENST00000553981 ENST00000556956
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat SLIRP

    Additional mRNA sequence: 

    AF253980.1 AF271779.1 AJ272055.1 AY860853.1 BC017895.1 NR_052025.1 

    16 DOTS entries:

    DT.101959452  DT.205936  DT.116858  DT.101983692  DT.120787428  DT.92412491  DT.92430511  DT.101983691 
    DT.100793671  DT.75174198  DT.100030853  DT.116859  DT.120787377  DT.120787404  DT.120787439  DT.95308927 

    Selected AceView cDNA sequences (see all 267):

    BU070572 AI150756 BU726271 BQ777999 AI023676 F35313 AA534561 AA541603 
    AI130748 AA927025 AA694164 AA603795 AA524049 AA694524 AA780729 BF445896 
    F34894 BM661754 BQ581622 AA947143 AI309287 BQ614067 AI475127 AA926970 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLIRP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGAAGGTG
    SLIRP Expression
    About this image


    SLIRP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
    SLIRP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLIRP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655105

    UniProtKB/Swiss-Prot: SLIRP_HUMAN, Q9GZT3
    Tissue specificity: Ubiquitously expressed, with highest level in heart, liver, skeletal muscle and testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLIRP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slirp1 , 5 RIKEN cDNA 1810035L17 gene5
    SRA stem-loop interacting RNA binding protein1
    82.25(n)1
    72.83(a)1
      12 (41.67 cM)5
    3807731  NM_026958.31  NP_081234.21 
     874438965 
    chicken
    (Gallus gallus)
    Aves SLIRP1 SRA stem-loop interacting RNA binding protein 60.95(n)
    52.86(a)
      772054  XM_001235248.3  XP_001235249.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slirp1 SRA stem-loop interacting RNA binding protein 63.89(n)
    62.5(a)
      100489427  XM_002938859.2  XP_002938905.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-276n11.11 si:ch73-276n11.1 67.12(n)
    59.46(a)
      368358  XM_002665165.3  XP_002665211.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG337146
    CG80216
    --
    31(a)
    29(a)
    many → 1
    many → 1
    X(21188961-21190299)
    3R(4476806-4477215)


    ENSEMBL Gene Tree for SLIRP (if available)
    TreeFam Gene Tree for SLIRP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLIRP gene
    9 SIMAP similar genes for SLIRP using alignment to 8 protein entries:     SLIRP_HUMAN (see all proteins):
    HNRNPD    DAZAP1    HNRNPAB    MSI2    HNRNPA0    TARDBP
    RBM28    DAZAP1/MEF2D fusion    PABPN1

    Find genes that share paralogs with SLIRP           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for SLIRP
    PGOHUM00000261863 PGOHUM00000261879 PGOHUM00000245481 PGOHUM00000242066


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLIRP (see all 179)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1893395761,2
    --78176408(+) ATATTA/GTAAAA 4 -- int10--------
    rs788092091,2
    C--78176596(+) AAGGAC/TAGTTA 4 -- int10--------
    rs791881711,2
    F--78176640(+) TACCAA/GCATAT 4 -- int11Minor allele frequency- G:0.02WA 118
    rs1821788671,2
    --78176644(+) AACATA/GTGGAG 4 -- int10--------
    rs1384320511,2
    --78176683(+) AACCCA/GCAGGA 4 -- int10--------
    rs1176989401,2
    C,F--78176706(+) ATTCAA/GTTAGT 4 -- int11Minor allele frequency- G:0.03NA 120
    rs748335161,2
    F--78176755(+) AGGCAG/CGAAGG 4 -- int11Minor allele frequency- C:0.02WA 118
    rs10778431,2
    C,H--78176789(-) ATTTAG/ATAAAA 4 -- int18Minor allele frequency- A:0.06NA EA NS 652
    rs10764961,2
    C,F,H--78176851(-) CAGTGT/CGTTTC 4 -- int128Minor allele frequency- C:0.44EA NA NS WA CSA 3068
    rs1164317741,2
    C,F--78176976(+) ACTCAA/GCAACT 4 -- int1 nc-transcript-variant1Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for SLIRP (78174414 - 78227447 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SLIRP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv521287CNV Gain19592680
    esv34940CNV Gain17911159
    nsv520021CNV Gain19592680
    essv7944CNV CNV17122850
    dgv643e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLIRP
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610211    OMIM disorders: --


    Find genes that share disorders with SLIRP           About GenesLikeMe


    Export disorders for SLIRP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLIRP gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with SLIRP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SLIRP, a small SRA binding protein, is a nuclear receptor corepressor. (PubMed id 16762838)1, 2, 3 Hatchell E.C.... Leedman P.J. (Mol. Cell 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    4. Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (Mol. Endocrinol. 2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    7. LRPPRC/SLIRP suppresses PNPase-mediated mRNA decay and promotes polyadenylation in human mitochondria. (PubMed id 22661577)1 Chujo T....Suzuki T. (Nucleic Acids Res. 2012)
    8. A bead-based approach for large-scale identification of in vitro kinase substrates. (PubMed id 22113938)1 Zhang M....Zou H. (Proteomics 2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81892 HGNC: 20495 AceView: C14orf156 Ensembl:ENSG00000119705 euGenes: HUgn81892
    ECgene: SLIRP H-InvDB: SLIRP

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLIRP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLIRP gene:
    Search GeneIP for patents involving SLIRP

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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