Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLIRP Gene

protein-coding GIFtS: 45
GCID: GC14P078175

SRA stem-loop interacting RNA binding protein

(Previous name: chromosome 14 open reading frame 156 )
(Previous symbol: C14orf156)

Explore 1 disease affiliated with
SLIRP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SRA Stem-Loop Interacting RNA Binding Protein¹ ²
C14orf156¹ ² ³ ⁵
DC50¹ ²
Chromosome 14 Open Reading Frame 156¹
PD04872²
SRA Stem-Loop-Interacting RNA-Binding Protein, Mitochondrial²

External Ids:	HGNC: 20495¹	Entrez Gene: 81892²	Ensembl: ENSG00000119705⁷	OMIM: 610211⁵	UniProtKB: Q9GZT3³

Export aliases for SLIRP gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLIRP:

Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable

stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7

of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 (PubMed 16762838)).(supplied by

OMIM, Mar 2008)

UniProtKB/Swiss-Prot: SLIRP_HUMAN, Q9GZT3

Function: RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and

repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress

glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for SLIRP
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLIRP promoter sequence

Search SABiosciences Chromatin IP Primers for SLIRP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLIRP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.3

SLIRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLIRP gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P078175: view genomic region (about GC identifiers)

Start:	78,174,414 bp from pter	End:	78,227,447 bp from pter
Size:	53,034 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SLIRP_HUMAN, Q9GZT3 (See protein sequence)

Recommended Name: SRA stem-loop-interacting RNA-binding protein, mitochondrial precursor

Size: 109 amino acids; 12349 Da

Subcellular location: Mitochondrion. Nucleus. Note=Predominantly mitochondrial. Some fraction is nuclear. In the

nucleus, it is recruited to nuclear receptor target promoters

Explore the universe of human proteins at neXtProt for SLIRP: NX_Q9GZT3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9GZT3

SLIRP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001254792.1 NP_001254793.1 NP_112487.1

ENSEMBL proteins:

ENSP00000450909 ENSP00000238688 ENSP00000452057 ENSP00000450849 ENSP00000451606

ENSP00000450770 ENSP00000452162 ENSP00000452329 ENSP00000450587

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SLIRP OriGene Protein Over-expression Lysate: SLIRP OriGene Custom Protein Services for SLIRP
	GenScript Custom Purified and Recombinant Proteins Services for SLIRP
	Novus Biologicals SLIRP Protein Novus Biologicals SLIRP Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLIRP

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005739	mitochondrion	IDA	--

SLIRP for ontologies About GeneDecksing

SLIRP Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: SLIRP OriGene Custom Antibody Services for SLIRP
	GenScript Custom Superior Antibodies Services for SLIRP
	Novus Biologicals SLIRP Antibodies
	Search for Antibodies for SLIRP at Abcam
	Uscn Antibodies for SLIRP
	ThermoFisher Antibodies for SLIRP

Assay Products for SLIRP:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SLIRP
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SLIRP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLIRP for domains About GeneDecksing

2 InterPro domains/families:

IPR000504 RRM_dom

IPR012677 Nucleotide-bd_a/b_plait

Graphical View of Domain Structure for InterPro Entry Q9GZT3

ProtoNet protein and cluster: Q9GZT3

1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

UniProtKB/Swiss-Prot: SLIRP_HUMAN, Q9GZT3

Similarity: Contains 1 RRM (RNA recognition motif) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SLIRP_HUMAN, Q9GZT3

Function: RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and

repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress

glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation

miRNA Products:		OriGene 3'-UTR Clone: SLIRP Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLIRP
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SLIRP
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLIRP (see all 4) OriGene shRNA RFP: SLIRP OriGene siRNA: SLIRP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLIRP

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SLIRP

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLIRP (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLIRP OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for SLIRP
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLIRP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLIRP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SLIRP
		Search LifeMap BioReagents cell lines for SLIRP

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SLIRP

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003676	nucleic acid binding	--	--
GO:0003723	RNA binding	IEA	--

SLIRP for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLIRP

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/241 Interacting proteins for SLIRP (Q9GZT3^{2, 3} ENSP00000238688⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 241)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ICT1	Q14197²^,³, ENSP00000301585⁴	MINT-8079030 I2D: score=1 STRING: ENSP00000301585
SLX1A	Q9BQ83³, ENSP00000251303⁴	I2D: score=2 STRING: ENSP00000251303
SLX1B	Q9BQ83³, ENSP00000328940⁴	I2D: score=2 STRING: ENSP00000328940
LRPPRC	P42704², ENSP00000260665⁴	MINT-8340644 MINT-8079030 STRING: ENSP00000260665
BABAM1	Q9NWV8³, ENSP00000352408⁴	I2D: score=2 STRING: ENSP00000352408

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

SLIRP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLIRP
Search CenterWatch for drugs/clinical trials and news about SLIRP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLIRP gene (3 alternative transcripts):

NM_001267863.1 NM_001267864.1 NM_031210.5

Unigene Cluster for SLIRP:

SRA stem-loop interacting RNA binding protein

Hs.655105 [show with all ESTs]

Unigene Representative Sequence: BQ278491

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000557342(uc001xue.4) ENST00000238688 ENST00000557623 ENST00000557431

ENST00000555890 ENST00000556831 ENST00000554074 ENST00000556375 ENST00000556310

ENST00000553981 ENST00000556956

miRNA Products:		OriGene 3'-UTR Clone: SLIRP Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLIRP
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SLIRP
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLIRP (see all 4) OriGene shRNA RFP: SLIRP OriGene siRNA: SLIRP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLIRP

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLIRP (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLIRP OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for SLIRP
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLIRP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLIRP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLIRP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SLIRP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLIRP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLIRP

Additional cDNA sequence:

AF253980.1 AF271779.1 AJ272055.1 AY860853.1 BC017895.1 NR_052025.1

16 DOTS entries:

DT.101959452 DT.205936 DT.116858 DT.101983692 DT.120787428 DT.92412491 DT.92430511 DT.101983691

DT.100793671 DT.75174198 DT.100030853 DT.116859 DT.120787377 DT.120787404 DT.120787439 DT.95308927

24/267 AceView cDNA sequences (see all 267):

AA704855 AI130748 BF445896 AA603795 AA927025 AA541603 AA694524 BU070572

AI150756 BM661888 AA694164 F33405 AI475127 F34894 BQ777999 BU726271

BQ581622 AA534561 AA524049 BM661754 AI023676 BM690034 AA780729 F35313

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLIRP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAGAAGGTG

About this image

SLIRP expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Ventral Foregut Endoderm

Gut Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Endoderm-like cells (Generation of hepato...)

See SLIRP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLIRP

SOURCE GeneReport for Unigene cluster: Hs.655105

UniProtKB/Swiss-Prot: SLIRP_HUMAN, Q9GZT3

Tissue specificity: Ubiquitously expressed, with highest level in heart, liver, skeletal muscle and testis

SABiosciences Custom PCR Arrays for SLIRP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLIRP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SLIRP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLIRP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLIRP

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SLIRP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SLIRP gene from 5/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Slirp^{1 , 5}	RIKEN cDNA 1810035L17 gene⁵ SRA stem-loop interacting RNA binding protein¹	78.62(n)¹ 71.7(a)¹		12 (41.67 cM)⁵ 380773¹ NM_026958.3¹ NP_081234.2¹ 87443896⁵
chicken (Gallus gallus)	Aves	SLIRP¹	SRA stem-loop interacting RNA binding protein	53.7(n) 47.78(a)		772054 XM_001235248.2 XP_001235249.1
zebrafish (Danio rerio)	Actinopterygii	sb:cb657¹	sb:cb657	62.88(n) 55.68(a)		368358 XM_002665165.2 XP_002665211.1
fruit fly (Drosophila melanogaster)	Insecta	CG33714⁶ CG8021⁶	--	31(a) 26(a)	many → 1 many → 1	X(21188961-21190299) 3R(4476806-4477215)
worm (Caenorhabditis elegans)	Secernentea	C50B8.1⁶	Protein C50B8.1	24(a)	1 ↔ 1	V(13565849-13566946)

ENSEMBL Gene Tree for SLIRP (if available)
TreeFam Gene Tree for SLIRP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLIRP gene

9 SIMAP similar genes for SLIRP using alignment to 9 protein entries: SLIRP_HUMAN (see all proteins):

HNRNPD DAZAP1 HNRNPAB HNRNPA0 MSI2 TARDBP

RBM28 DAZAP1/MEF2D fusion PABPN1

SLIRP for paralogs About GeneDecksing

4 Pseudogenes.org Pseudogenes for SLIRP
PGOHUM00000261863 PGOHUM00000261879 PGOHUM00000245481 PGOHUM00000242066

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189339576^1,2		--	78176408(+)	`ATATTA/GTAAAA`	4	--	int¹		0	--	--	--	--
rs78809209^1,2		--	78176596(+)	`AAGGAC/TAGTTA`	4	--	int¹		0	--	--	--	--
rs79188171^1,2	F,	--	78176640(+)	`TACCAA/GCATAT`	4	--	int¹		1		WA	118
rs182178867^1,2		--	78176644(+)	`AACATA/GTGGAG`	4	--	int¹		0	--	--	--	--
rs138432051^1,2		--	78176683(+)	`AACCCA/GCAGGA`	4	--	int¹		0	--	--	--	--
rs117698940^1,2	C,F,	--	78176706(+)	`ATTCAA/GTTAGT`	4	--	int¹		1		NA	120
rs74833516^1,2	F,	--	78176755(+)	`AGGCAG/CGAAGG`	4	--	int¹		1		WA	118
rs1077843^1,2	C,H	--	78176789(-)	`ATTTAG/ATAAAA`	4	--	int¹		8		NA EA NS	652
rs1076496^1,2	C,F,H,	--	78176851(-)	`CAGTGT/CGTTTC`	4	--	int¹		28		EA NA NS WA CSA	3068
rs116431774^1,2	F,	--	78176976(+)	`ACTCAA/GCAACT`	4	--	int¹ nc-transcript-variant		1		WA	118

HapMap Linkage Disequilibrium report for SLIRP (78174414 - 78227447 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLIRP: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLIRP

DNA2.0 Custom Variant and Variant Library Synthesis for SLIRP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLIRP for disorders           About GeneDecksing

OMIM gene information: 610211    OMIM disorders: --

1 disease for SLIRP:    About MalaCards

thyroiditis

Export disorders for SLIRP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLIRP gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with SLIRP)

Utopia: connect your pdf to the dynamic
world of online information

SLIRP, a small SRA binding protein, is a nuclear receptor corepressor. (PubMed id 16762838)^{1, 2, 3} Hatchell E.C.... Leedman P.J. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Global landscape of HIV-human protein complexes. (PubMed id 22190034)¹ Jager S....Krogan N.J. (2012)
LRPPRC/SLIRP suppresses PNPase-mediated mRNA decay and promotes polyadenylation in human mitochondria. (PubMed id 22661577)¹ Chujo T....Suzuki T. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 81892	HGNC: 20495	AceView: C14orf156	Ensembl:ENSG00000119705	euGenes: HUgn81892
ECgene: SLIRP	H-InvDB: SLIRP

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLIRP	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLIRP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SLIRP gene:
Search GeneIP for patents involving SLIRP

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for SLIRP		OriGene shRNA RFP for SLIRP
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLIRP		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLIRP
	OriGene Protein Over-expression Lysate for SLIRP		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SLIRP		OriGene 3'-UTR Clone for SLIRP
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLIRP		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLIRP
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for SLIRP		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SLIRP		OriGene Custom Protein Services for SLIRP
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLIRP
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLIRP
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLIRP
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLIRP
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLIRP
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLIRP

	GenScript Custom Purified and Recombinant Proteins Services for SLIRP		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for SLIRP
	GenScript Custom Assay Services for SLIRP		GenScript Custom Superior Antibodies Services for SLIRP
	GenScript Custom overexpressing Cell Line Services for SLIRP		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Search Regulatory tfbs for SLIRP
	Search Chromatin IP Primers for SLIRP
	RT² qPCR Primer Assay in human, mouse, rat SLIRP
	Search GNC Networks for SLIRP
	SABiosciences Custom PCR Arrays for SLIRP

Search Tocris compounds for SLIRP

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SLIRP antibodies
	SLIRP proteins
	SLIRP lysates

	Search for Antibodies for SLIRP at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for SLIRP
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

SLIRP Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SLIRP

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SLIRP

	Browse SwitchGear 3'UTR luciferase reporter plasmids for SLIRP
	SwitchGear Promoter luciferase reporter plasmids for SLIRP

ThermoFisher Antibodies for SLIRP

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLIRP

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SLIRP gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

SLIRP Gene

SRA stem-loop interacting RNA binding protein

Aliases
for SLIRP gene

Summaries
for SLIRP gene

Genomic Views
for SLIRP gene

Proteins
for SLIRP gene

Protein Domains /
Families
for SLIRP gene

Function
for SLIRP gene

Pathways & Interactions
for SLIRP gene

Drugs & Compounds
for SLIRP gene

Transcripts
for SLIRP gene

Expression
for SLIRP gene

Orthologs
for SLIRP gene

Paralogs
for SLIRP gene

Genomic Variants
for SLIRP gene

Disorders / Diseases
for SLIRP gene

Publications
for SLIRP gene

External Searches for SLIRP gene

Genome Databases showing SLIRP gene

Other Databases showing SLIRP gene

Specialized Databases showing SLIRP gene

Intellectual Property
for SLIRP gene

Products
for SLIRP gene

View Random Gene

Advanced Search

Export list of displayed genes

SLIRP Gene

SRA stem-loop interacting RNA binding protein

Aliasesfor SLIRP gene

Summariesfor SLIRP gene

Genomic Viewsfor SLIRP gene

Proteinsfor SLIRP gene

Protein Domains /Familiesfor SLIRP gene

Functionfor SLIRP gene

Pathways & Interactionsfor SLIRP gene

Drugs & Compoundsfor SLIRP gene

Transcriptsfor SLIRP gene

Expression for SLIRP gene

Orthologsfor SLIRP gene

Paralogsfor SLIRP gene

Genomic Variantsfor SLIRP gene

Disorders / Diseasesfor SLIRP gene

Publicationsfor SLIRP gene

External Searches for SLIRP gene

Genome Databases showing SLIRP gene

Other Databases showing SLIRP gene

Specialized Databases showing SLIRP gene

Intellectual Propertyfor SLIRP gene

Productsfor SLIRP gene

View Random Gene

Aliases
for SLIRP gene

Summaries
for SLIRP gene

Genomic Views
for SLIRP gene

Proteins
for SLIRP gene

Protein Domains /
Families
for SLIRP gene

Function
for SLIRP gene

Pathways & Interactions
for SLIRP gene

Drugs & Compounds
for SLIRP gene

Transcripts
for SLIRP gene

Expression
for SLIRP gene

Orthologs
for SLIRP gene

Paralogs
for SLIRP gene

Genomic Variants
for SLIRP gene

Disorders / Diseases
for SLIRP gene

Publications
for SLIRP gene

Intellectual Property
for SLIRP gene

Products
for SLIRP gene