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Aliases for SLIRP Gene

Aliases for SLIRP Gene

  • SRA Stem-Loop Interacting RNA Binding Protein 2 3
  • C14orf156 3 4 6
  • SRA Stem-Loop-Interacting RNA-Binding Protein, Mitochondrial 3
  • Chromosome 14 Open Reading Frame 156 2
  • PD04872 3
  • DC50 3

External Ids for SLIRP Gene

Previous HGNC Symbols for SLIRP Gene

  • C14orf156

Previous GeneCards Identifiers for SLIRP Gene

  • GC14P078175

Summaries for SLIRP Gene

Entrez Gene Summary for SLIRP Gene

  • Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 [PubMed 16762838]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLIRP Gene

SLIRP (SRA Stem-Loop Interacting RNA Binding Protein) is a Protein Coding gene. GO annotations related to this gene include RNA binding and nucleotide binding.

UniProtKB/Swiss-Prot for SLIRP Gene

  • RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLIRP Gene

Genomics for SLIRP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLIRP Gene

Start:
77,708,071 bp from pter
End:
77,761,104 bp from pter
Size:
53,034 bases
Orientation:
Plus strand

Genomic View for SLIRP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLIRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLIRP Gene

No data available for Regulatory Elements for SLIRP Gene

Proteins for SLIRP Gene

  • Protein details for SLIRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZT3-SLIRP_HUMAN
    Recommended name:
    SRA stem-loop-interacting RNA-binding protein, mitochondrial
    Protein Accession:
    Q9GZT3
    Secondary Accessions:
    • J3KMY7

    Protein attributes for SLIRP Gene

    Size:
    109 amino acids
    Molecular mass:
    12349 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLIRP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLIRP Gene

Proteomics data for SLIRP Gene at MOPED

Post-translational modifications for SLIRP Gene

  • Ubiquitination at Lys36 and Lys88
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLIRP Gene

Domains for SLIRP Gene

Gene Families for SLIRP Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for SLIRP Gene

Suggested Antigen Peptide Sequences for SLIRP Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZT3

UniProtKB/Swiss-Prot:

SLIRP_HUMAN :
  • Q9GZT3
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with SLIRP: view

Function for SLIRP Gene

Molecular function for SLIRP Gene

UniProtKB/Swiss-Prot Function: RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation.

Gene Ontology (GO) - Molecular Function for SLIRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SLIRP: view

Phenotypes for SLIRP Gene

genes like me logo Genes that share phenotypes with SLIRP: view

Animal Models for SLIRP Gene

MGI Knock Outs for SLIRP:

Animal Model Products

CRISPR Products

miRNA for SLIRP Gene

miRTarBase miRNAs that target SLIRP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLIRP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLIRP Gene

Localization for SLIRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLIRP Gene

Mitochondrion. Nucleus. Note=Predominantly mitochondrial. Some fraction is nuclear. In the nucleus, it is recruited to nuclear receptor target promoters.

Gene Ontology (GO) - Cellular Components for SLIRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IDA --
GO:0030529 ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with SLIRP: view

No data available for Subcellular locations from COMPARTMENTS for SLIRP Gene

Pathways for SLIRP Gene

SuperPathways for SLIRP Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLIRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000961 negative regulation of mitochondrial RNA catabolic process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007286 spermatid development IEA --
GO:0007338 single fertilization IEA --
genes like me logo Genes that share ontologies with SLIRP: view

No data available for Pathways by source for SLIRP Gene

Transcripts for SLIRP Gene

Unigene Clusters for SLIRP Gene

SRA stem-loop interacting RNA binding protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLIRP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLIRP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLIRP Gene

No ASD Table

Relevant External Links for SLIRP Gene

GeneLoc Exon Structure for
SLIRP
ECgene alternative splicing isoforms for
SLIRP

Expression for SLIRP Gene

mRNA expression in normal human tissues for SLIRP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLIRP Gene

SOURCE GeneReport for Unigene cluster for SLIRP Gene Hs.655105

mRNA Expression by UniProt/SwissProt for SLIRP Gene

Q9GZT3-SLIRP_HUMAN
Tissue specificity: Ubiquitously expressed, with highest level in heart, liver, skeletal muscle and testis.
genes like me logo Genes that share expressions with SLIRP: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLIRP Gene

Orthologs for SLIRP Gene

This gene was present in the common ancestor of animals.

Orthologs for SLIRP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLIRP 35
  • 99.69 (n)
  • 100 (a)
SLIRP 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 44 (a)
OneToMany
SLIRP 35
  • 81.35 (n)
  • 73.39 (a)
SLIRP 36
  • 72 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SLIRP 35
  • 82.11 (n)
  • 74.74 (a)
SLIRP 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slirp 35
  • 82.25 (n)
  • 72.83 (a)
Slirp 16
Slirp 36
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLIRP 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLIRP 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slirp 35
  • 82.25 (n)
  • 72.83 (a)
chicken
(Gallus gallus)
Aves SLIRP 35
  • 60.95 (n)
  • 52.86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slirp 35
  • 63.89 (n)
  • 62.5 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-276n11.1 35
  • 67.12 (n)
  • 59.46 (a)
SLIRP 36
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG33714 36
  • 31 (a)
OneToMany
CG8021 36
  • 29 (a)
OneToMany
Species with no ortholog for SLIRP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLIRP Gene

ENSEMBL:
Gene Tree for SLIRP (if available)
TreeFam:
Gene Tree for SLIRP (if available)

Paralogs for SLIRP Gene

Pseudogenes.org Pseudogenes for SLIRP Gene

genes like me logo Genes that share paralogs with SLIRP: view

No data available for Paralogs for SLIRP Gene

Variants for SLIRP Gene

Sequence variations from dbSNP and Humsavar for SLIRP Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs176945 -- 77,711,310(+) TTGTT(C/G)AAAAA intron-variant
rs176946 -- 77,712,096(+) caagc(A/G)taatg intron-variant
rs176947 -- 77,712,604(+) tacgc(C/T)cggct intron-variant
rs176948 -- 77,712,761(+) tttaa(C/T)tgtag intron-variant
rs176949 -- 77,712,849(+) tgtta(A/C)ctagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLIRP Gene

Variant ID Type Subtype PubMed ID
dgv643e1 CNV Complex 17122850
essv7944 CNV CNV 17122850
esv34940 CNV Gain 17911159
nsv521287 CNV Gain 19592680
nsv520021 CNV Gain 19592680

Relevant External Links for SLIRP Gene

HapMap Linkage Disequilibrium report
SLIRP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLIRP Gene

Disorders for SLIRP Gene

No disorders were found for SLIRP Gene.

No data available for UniProtKB/Swiss-Prot for SLIRP Gene

Publications for SLIRP Gene

  1. SLIRP, a small SRA binding protein, is a nuclear receptor corepressor. (PMID: 16762838) Hatchell E.C. … Leedman P.J. (Mol. Cell 2006) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Large-scale analysis of the human ubiquitin-related proteome. (PMID: 16196087) Matsumoto M. … Nakayama K.I. (Proteomics 2005) 3
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for SLIRP Gene

Sources for SLIRP Gene

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