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Aliases for SLFNL1 Gene

Aliases for SLFNL1 Gene

  • Schlafen Like 1 2 3 5
  • Schlafen-Like 1 2

External Ids for SLFNL1 Gene

Previous GeneCards Identifiers for SLFNL1 Gene

  • GC01M041253
  • GC01M041481
  • GC01M039598

Summaries for SLFNL1 Gene

GeneCards Summary for SLFNL1 Gene

SLFNL1 (Schlafen Like 1) is a Protein Coding gene.

Additional gene information for SLFNL1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLFNL1 Gene

Genomics for SLFNL1 Gene

Regulatory Elements for SLFNL1 Gene

Enhancers for SLFNL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H040976 1.3 Ensembl ENCODE 24.3 +44.2 44240 6 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 ZNF207 FOS EXO5 SLFNL1 CTPS1 ENSG00000235358 NFYC RLF SCMH1 FOXO6 GC01M040907
GH01H040372 1.8 FANTOM5 ENCODE dbSUPER 12.8 +647.6 647592 5 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF766 PPIEL PPIE TRIT1 EXO5 SMAP2 ENSG00000259943 ENSG00000182109 RLF NFYC-AS1 LOC105378674
GH01H041869 1.5 Ensembl ENCODE dbSUPER 12.8 -846.7 -846687 1 PKNOX1 ATF1 FEZF1 ZNF2 GLIS2 GATA2 ATF7 FOS RUNX3 SP3 FOXJ3 SLFNL1 P3H1 HIVEP3 PIR53563 GC01M041738
GH01H040690 1.4 ENCODE dbSUPER 12.9 +330.7 330743 4 ZFP64 DMAP1 YY1 SLC30A9 SP3 NFYC MEF2D ZNF610 GLIS1 NBN ENSG00000259943 RIMS3 EXO5 NFYC-AS1 RLF LOC105378674 ZFP69 SLFNL1 TRIT1 MIR30C1
GH01H041473 1.3 Ensembl ENCODE dbSUPER 9.1 -452.4 -452365 3 ELF3 FOXA2 PKNOX1 RAD21 YY1 SCRT2 RCOR1 THAP11 CEBPB REST LOC101929901 ENSG00000230881 LOC100418723 SLFNL1 CTPS1 FOXO6 GC01M041472 RNA5SP45
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLFNL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLFNL1 Gene

Chromosome:
1
Start:
41,015,597 bp from pter
End:
41,023,444 bp from pter
Size:
7,848 bases
Orientation:
Minus strand

Genomic View for SLFNL1 Gene

Genes around SLFNL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLFNL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLFNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLFNL1 Gene

Proteins for SLFNL1 Gene

  • Protein details for SLFNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q499Z3-SLNL1_HUMAN
    Recommended name:
    Schlafen-like protein 1
    Protein Accession:
    Q499Z3
    Secondary Accessions:
    • A8K8D1
    • Q49AG8
    • Q5VW72
    • Q5VW74
    • Q8N7V7
    • Q8TCH6
    • Q8WVZ8

    Protein attributes for SLFNL1 Gene

    Size:
    407 amino acids
    Molecular mass:
    45603 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLFNL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLFNL1 Gene

Post-translational modifications for SLFNL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLFNL1 Gene

Domains & Families for SLFNL1 Gene

Gene Families for SLFNL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SLFNL1 Gene

Suggested Antigen Peptide Sequences for SLFNL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q499Z3

UniProtKB/Swiss-Prot:

SLNL1_HUMAN :
  • Belongs to the Schlafen family.
Family:
  • Belongs to the Schlafen family.
genes like me logo Genes that share domains with SLFNL1: view

Function for SLFNL1 Gene

Gene Ontology (GO) - Molecular Function for SLFNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SLFNL1: view

Phenotypes for SLFNL1 Gene

genes like me logo Genes that share phenotypes with SLFNL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLFNL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLFNL1 Gene

Localization for SLFNL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLFNL1 gene
Compartment Confidence
nucleus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SLFNL1 Gene

Pathways & Interactions for SLFNL1 Gene

SuperPathways for SLFNL1 Gene

No Data Available

Interacting Proteins for SLFNL1 Gene

Selected Interacting proteins: Q499Z3-SLNL1_HUMAN for SLFNL1 Gene via IID

Symbol External ID(s) Details
APP

Gene Ontology (GO) - Biological Process for SLFNL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLFNL1 Gene

Drugs & Compounds for SLFNL1 Gene

No Compound Related Data Available

Transcripts for SLFNL1 Gene

Unigene Clusters for SLFNL1 Gene

Schlafen-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLFNL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLFNL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7
SP1: - -
SP2:
SP3:
SP4: - -
SP5: -
SP6: -
SP7: -
SP8: -

Relevant External Links for SLFNL1 Gene

GeneLoc Exon Structure for
SLFNL1
ECgene alternative splicing isoforms for
SLFNL1

Expression for SLFNL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLFNL1 Gene

mRNA differential expression in normal tissues according to GTEx for SLFNL1 Gene

This gene is overexpressed in Testis (x27.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLFNL1 Gene



Protein tissue co-expression partners for SLFNL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLFNL1 Gene:

SLFNL1

SOURCE GeneReport for Unigene cluster for SLFNL1 Gene:

Hs.194609

Evidence on tissue expression from TISSUES for SLFNL1 Gene

  • Nervous system(4.1)
  • Lung(4)
genes like me logo Genes that share expression patterns with SLFNL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLFNL1 Gene

Orthologs for SLFNL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLFNL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLFNL1 33 34
  • 99.02 (n)
dog
(Canis familiaris)
Mammalia SLFNL1 33 34
  • 79.3 (n)
cow
(Bos Taurus)
Mammalia SLFNL1 33 34
  • 78.18 (n)
mouse
(Mus musculus)
Mammalia Slfnl1 33 16 34
  • 78.16 (n)
rat
(Rattus norvegicus)
Mammalia Slfnl1 33
  • 77.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
OneToMany
-- 34
  • 39 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SLFNL1 34
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLFNL1 34
  • 49 (a)
OneToOne
Species where no ortholog for SLFNL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLFNL1 Gene

ENSEMBL:
Gene Tree for SLFNL1 (if available)
TreeFam:
Gene Tree for SLFNL1 (if available)

Paralogs for SLFNL1 Gene

No data available for Paralogs for SLFNL1 Gene

Variants for SLFNL1 Gene

Sequence variations from dbSNP and Humsavar for SLFNL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000168038 -- 41,021,273(+) TCACG(A/C)TTTTT intron-variant, utr-variant-5-prime
rs1001209020 -- 41,022,148(+) GCCAG(G/T)CCCTT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001224468 -- 41,021,578(+) TGGGG(A/G)CATTC intron-variant, utr-variant-5-prime
rs1001385193 -- 41,015,248(+) GCTAA(C/T)GGTCT intron-variant, nc-transcript-variant, downstream-variant-500B
rs1002238206 -- 41,022,716(+) ACCCC(C/G)TCTCC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SLFNL1 Gene

Variant ID Type Subtype PubMed ID
nsv546103 CNV loss 21841781

Variation tolerance for SLFNL1 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.19; 80.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLFNL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLFNL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLFNL1 Gene

Disorders for SLFNL1 Gene

Relevant External Links for SLFNL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLFNL1

No disorders were found for SLFNL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLFNL1 Gene

Publications for SLFNL1 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 60
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60

Products for SLFNL1 Gene

Sources for SLFNL1 Gene

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