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Aliases for SLFN5 Gene

Aliases for SLFN5 Gene

  • Schlafen Family Member 5 2 3 5

External Ids for SLFN5 Gene

Previous GeneCards Identifiers for SLFN5 Gene

  • GC17U900473
  • GC17M030826
  • GC17P030595
  • GC17P033570
  • GC17P029754

Summaries for SLFN5 Gene

GeneCards Summary for SLFN5 Gene

SLFN5 (Schlafen Family Member 5) is a Protein Coding gene. An important paralog of this gene is SLFN14.

UniProtKB/Swiss-Prot for SLFN5 Gene

  • May have a role in hematopoietic cell differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLFN5 Gene

Genomics for SLFN5 Gene

Regulatory Elements for SLFN5 Gene

Enhancers for SLFN5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLFN5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLFN5 Gene

35,243,036 bp from pter
35,273,655 bp from pter
30,620 bases
Plus strand

Genomic View for SLFN5 Gene

Genes around SLFN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLFN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLFN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLFN5 Gene

Proteins for SLFN5 Gene

  • Protein details for SLFN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Schlafen family member 5
    Protein Accession:
    Secondary Accessions:
    • Q08AF2
    • Q8WU54
    • Q96A82

    Protein attributes for SLFN5 Gene

    891 amino acids
    Molecular mass:
    101055 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLFN5 Gene


neXtProt entry for SLFN5 Gene

Proteomics data for SLFN5 Gene at MOPED

Post-translational modifications for SLFN5 Gene

  • Ubiquitination at Lys 65, Lys 138, and Lys 584
  • Modification sites at PhosphoSitePlus

Other Protein References for SLFN5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLFN5 Gene

Domains & Families for SLFN5 Gene

Gene Families for SLFN5 Gene

Protein Domains for SLFN5 Gene

Suggested Antigen Peptide Sequences for SLFN5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Schlafen family.
  • Belongs to the Schlafen family.
genes like me logo Genes that share domains with SLFN5: view

Function for SLFN5 Gene

Molecular function for SLFN5 Gene

UniProtKB/Swiss-Prot Function:
May have a role in hematopoietic cell differentiation.

Phenotypes for SLFN5 Gene

genes like me logo Genes that share phenotypes with SLFN5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLFN5 Gene

Localization for SLFN5 Gene

Subcellular locations from

Jensen Localization Image for SLFN5 Gene COMPARTMENTS Subcellular localization image for SLFN5 gene
Compartment Confidence
nucleus 4
cytosol 3
peroxisome 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SLFN5 Gene

Pathways & Interactions for SLFN5 Gene

SuperPathways for SLFN5 Gene

No Data Available

Interacting Proteins for SLFN5 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000299977 for SLFN5 Gene via STRING

Gene Ontology (GO) - Biological Process for SLFN5 Gene


No data available for Pathways by source and SIGNOR curated interactions for SLFN5 Gene

Drugs & Compounds for SLFN5 Gene

No Compound Related Data Available

Transcripts for SLFN5 Gene

Unigene Clusters for SLFN5 Gene

Schlafen family member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLFN5 Gene

No ASD Table

Relevant External Links for SLFN5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLFN5 Gene

mRNA expression in normal human tissues for SLFN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLFN5 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for SLFN5 Gene

This gene is overexpressed in Lymph node (19.0), Peripheral blood mononuclear cells (10.9), Tlymphocyte (10.8), CD8 Tcells (7.7), and CD4 Tcells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLFN5 Gene

SOURCE GeneReport for Unigene cluster for SLFN5 Gene Hs.709347

genes like me logo Genes that share expression patterns with SLFN5: view

Protein tissue co-expression partners for SLFN5 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SLFN5 Gene

Orthologs for SLFN5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLFN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia SLFN5 35
  • 80.4 (n)
  • 70.58 (a)
(Mus musculus)
Mammalia Slfn5 35
  • 73 (n)
  • 59.73 (a)
Slfn5 16
Slfn5 36
  • 58 (a)
(Pan troglodytes)
Mammalia SLFN5 35
  • 99.33 (n)
  • 98.65 (a)
SLFN5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slfn5 35
  • 71.55 (n)
  • 57.55 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
Species with no ortholog for SLFN5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLFN5 Gene

Gene Tree for SLFN5 (if available)
Gene Tree for SLFN5 (if available)

Paralogs for SLFN5 Gene

Paralogs for SLFN5 Gene

(6) SIMAP similar genes for SLFN5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLFN5: view

Variants for SLFN5 Gene

Sequence variations from dbSNP and Humsavar for SLFN5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11651240 - 35,265,572(+) TTCTC(C/T)GAAGG reference, missense, utr-variant-3-prime
rs2291189 - 35,265,602(+) CAAAG(C/T)AAGTG reference, missense, utr-variant-3-prime
rs16970806 - 35,265,472(+) AAGGT(C/G)TCCCA reference, missense, utr-variant-3-prime
rs1055636 -- 35,267,301(+) AAATT(A/C)GTAAA downstream-variant-500B, utr-variant-3-prime
rs2127828 -- 35,252,992(+) AATTT(C/G)GGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLFN5 Gene

Variant ID Type Subtype PubMed ID
esv2422399 CNV Deletion 17116639

Variation tolerance for SLFN5 Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.55; 91.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLFN5 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLFN5 Gene

Disorders for SLFN5 Gene

Relevant External Links for SLFN5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLFN5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLFN5 Gene

Publications for SLFN5 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Schlafen, a new family of growth regulatory genes that affect thymocyte development. (PMID: 9846487) Schwarz D.A. … Hedrick S.M. (Immunity 1998) 2 3
  3. Human Schlafen 5 (SLFN5) Is a Regulator of Motility and Invasiveness of Renal Cell Carcinoma Cells. (PMID: 26012550) Sassano A. … Platanias L.C. (Mol. Cell. Biol. 2015) 3
  4. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  5. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3

Products for SLFN5 Gene

Sources for SLFN5 Gene