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Aliases for SLFN5 Gene

Aliases for SLFN5 Gene

  • Schlafen Family Member 5 2 3 5

External Ids for SLFN5 Gene

Previous GeneCards Identifiers for SLFN5 Gene

  • GC17U900473
  • GC17M030826
  • GC17P030595
  • GC17P033570
  • GC17P029754

Summaries for SLFN5 Gene

GeneCards Summary for SLFN5 Gene

SLFN5 (Schlafen Family Member 5) is a Protein Coding gene. An important paralog of this gene is SLFN11.

UniProtKB/Swiss-Prot for SLFN5 Gene

  • May have a role in hematopoietic cell differentiation.

Additional gene information for SLFN5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLFN5 Gene

Genomics for SLFN5 Gene

Regulatory Elements for SLFN5 Gene

Enhancers for SLFN5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H035212 1.4 FANTOM5 Ensembl ENCODE dbSUPER 44.3 -27.9 -27945 5.4 PKNOX1 ETV1 ZNF133 BATF GABPA OSR2 PRDM6 ZNF157 CUX1 SPI1 SLFN5 NLE1 SLFN12L AP2B1 LINC02001 UNC45B ZNF830 SLC35G3
GH17H035241 1.3 ENCODE dbSUPER 45.5 +0.9 863 5.7 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF143 FOS SLFN5 UNC45B NLE1 LOC105371932
GH17H035256 1.5 Ensembl ENCODE dbSUPER 25 +14.0 14001 1.8 FOXA2 FEZF1 FOS TSHZ1 ZNF518A ZNF610 GLIS1 ZNF624 STAT3 WT1 SLFN5 RAD51D NLE1 SLFN12L ENSG00000267074 LOC105371932 ENSG00000267364
GH17H035252 1.4 Ensembl ENCODE dbSUPER 25 +10.6 10569 3.2 FOXA2 ZNF473 INSM2 SIN3A ZNF2 RAD21 YY1 POLR3A ZNF366 FOS ZNF830 SLFN5 LIG3 LOC105371742 LOC105371739 SLFN12L CCT6B NLE1 LOC105371932 ENSG00000267364
GH17H035083 2 FANTOM5 Ensembl ENCODE dbSUPER 13.1 -155.9 -155874 6.6 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 LIG3 ZNF830 RFFL SLFN5 CCT6B NLE1 RPL37P22
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLFN5 on UCSC Golden Path with GeneCards custom track

Promoters for SLFN5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000093465 264 3001 PKNOX1 ATF1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF766 GLIS2 KLF7

Genomic Locations for SLFN5 Gene

Genomic Locations for SLFN5 Gene
30,620 bases
Plus strand

Genomic View for SLFN5 Gene

Genes around SLFN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLFN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLFN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLFN5 Gene

Proteins for SLFN5 Gene

  • Protein details for SLFN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Schlafen family member 5
    Protein Accession:
    Secondary Accessions:
    • Q08AF2
    • Q8WU54
    • Q96A82

    Protein attributes for SLFN5 Gene

    891 amino acids
    Molecular mass:
    101055 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLFN5 Gene


neXtProt entry for SLFN5 Gene

Post-translational modifications for SLFN5 Gene

  • Ubiquitination at Lys65, Lys138, and isoforms=584
  • Modification sites at PhosphoSitePlus

Other Protein References for SLFN5 Gene

No data available for DME Specific Peptides for SLFN5 Gene

Domains & Families for SLFN5 Gene

Gene Families for SLFN5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SLFN5 Gene

Suggested Antigen Peptide Sequences for SLFN5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Schlafen family.
  • Belongs to the Schlafen family.
genes like me logo Genes that share domains with SLFN5: view

Function for SLFN5 Gene

Molecular function for SLFN5 Gene

UniProtKB/Swiss-Prot Function:
May have a role in hematopoietic cell differentiation.

Phenotypes From GWAS Catalog for SLFN5 Gene

Gene Ontology (GO) - Molecular Function for SLFN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SLFN5: view

Phenotypes for SLFN5 Gene

genes like me logo Genes that share phenotypes with SLFN5: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLFN5 Gene

Localization for SLFN5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLFN5 gene
Compartment Confidence
nucleus 4
cytosol 3
peroxisome 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLFN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SLFN5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SLFN5 Gene

Pathways & Interactions for SLFN5 Gene

SuperPathways for SLFN5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLFN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SLFN5: view

No data available for Pathways by source and SIGNOR curated interactions for SLFN5 Gene

Drugs & Compounds for SLFN5 Gene

No Compound Related Data Available

Transcripts for SLFN5 Gene

Unigene Clusters for SLFN5 Gene

Schlafen family member 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLFN5 Gene

No ASD Table

Relevant External Links for SLFN5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLFN5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLFN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLFN5 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for SLFN5 Gene

This gene is overexpressed in Lymph node (19.0), Peripheral blood mononuclear cells (10.9), Tlymphocyte (10.8), CD8 Tcells (7.7), and CD4 Tcells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLFN5 Gene

Protein tissue co-expression partners for SLFN5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLFN5 Gene:


SOURCE GeneReport for Unigene cluster for SLFN5 Gene:

genes like me logo Genes that share expression patterns with SLFN5: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLFN5 Gene

Orthologs for SLFN5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLFN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLFN5 33 34
  • 99.33 (n)
(Canis familiaris)
Mammalia SLFN5 33
  • 80.4 (n)
(Mus musculus)
Mammalia Slfn5 33 16 34
  • 73 (n)
(Rattus norvegicus)
Mammalia Slfn5 33
  • 71.55 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 50 (a)
Species where no ortholog for SLFN5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLFN5 Gene

Gene Tree for SLFN5 (if available)
Gene Tree for SLFN5 (if available)

Paralogs for SLFN5 Gene

Paralogs for SLFN5 Gene

(6) SIMAP similar genes for SLFN5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLFN5: view

Variants for SLFN5 Gene

Sequence variations from dbSNP and Humsavar for SLFN5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000068940 -- 35,252,816(+) AGTTC(C/T)TTAGA intron-variant
rs1000135414 -- 35,254,122(+) ACAAC(A/G)GTGCC intron-variant
rs1000169207 -- 35,253,649(+) GAATT(A/G)CAGGT intron-variant
rs1000502839 -- 35,252,132(+) AAACT(-/AA)AAAGA intron-variant
rs1000533898 -- 35,251,853(+) GGATT(A/G)CAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLFN5 Gene

Variant ID Type Subtype PubMed ID
nsv574741 CNV loss 21841781
nsv1127565 CNV deletion 24896259
esv3892999 CNV loss 25118596
esv3892998 CNV loss 25118596
esv3640444 CNV loss 21293372
esv2422399 CNV deletion 17116639

Variation tolerance for SLFN5 Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.55; 91.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLFN5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLFN5 Gene

Disorders for SLFN5 Gene

Relevant External Links for SLFN5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLFN5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLFN5 Gene

Publications for SLFN5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Schlafen, a new family of growth regulatory genes that affect thymocyte development. (PMID: 9846487) Schwarz DA … Hedrick SM (Immunity 1998) 2 3 60
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  5. Human Schlafen 5 (SLFN5) Is a Regulator of Motility and Invasiveness of Renal Cell Carcinoma Cells. (PMID: 26012550) Sassano A … Platanias LC (Molecular and cellular biology 2015) 3 60

Products for SLFN5 Gene

Sources for SLFN5 Gene

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