SLFN5 Gene
protein-coding GIFtS: 46
GCID: GC17P033570
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schlafen family member 5
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Aliases
for SLFN5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Schlafen Family Member 51 2 | | MGC197641 |
Export aliases for SLFN5 gene to outside databasesPrevious GC identifers: GC17U900473 GC17M030826 GC17P030595 GC17P029754 |
Summaries
for SLFN5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SLFN5_HUMAN, Q08AF3Function: May have a role in hematopoietic cell differentiation (By similarity)
|
Genomic Views
for SLFN5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SLFN5
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLFN5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLFN5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q12SLFN5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P033570: view genomic region
(about GC identifiers)
Start:
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33,570,055 bp from pter |
End:
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33,600,674 bp from pter |
Size:
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30,620 bases |
Orientation:
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plus strand |
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Proteins
for SLFN5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SLFN5_HUMAN, Q08AF3 (See
protein sequence)Recommended Name: Schlafen family member 5 Size: 891 amino acids; 101055 Da
Secondary accessions: Q08AF2 Q8WU54 Q96A82Alternative splicing: 2 isoforms: Q08AF3-1 Q08AF3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SLFN5: NX_Q08AF3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q08AF3
SLFN5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_659412.3
ENSEMBL proteins: ENSP00000299977 ENSP00000440537 ENSP00000466984
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
SLFN5 for ontologies About GeneDecksing
SLFN5 Antibody Products:
Assay Products for SLFN5: |
Protein
Domains /
Families
for SLFN5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLFN5 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q08AF3ProtoNet protein and cluster: Q08AF3 UniProtKB/Swiss-Prot: SLFN5_HUMAN, Q08AF3Similarity: Belongs to the Schlafen family |
Function
for SLFN5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SLFN5_HUMAN, Q08AF3Function: May have a role in hematopoietic cell differentiation (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLFN5 (NM_144975) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLFN5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLFN5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLFN5 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- |
SLFN5 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SLFN5:
|
Pathways & Interactions
for SLFN5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLFN5
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for SLFN5 (ENSP000002999774) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030154 | cell differentiation |
IEA | -- |
SLFN5 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLFN5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLFN5
Search CenterWatch for drugs/clinical trials and news about SLFN5
|
Transcripts
for SLFN5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLFN5 gene: NM_144975.3 Unigene Cluster for SLFN5: Schlafen family member 5 Hs.709347 [show with all ESTs]Unigene Representative Sequence: NM_1449753 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000299977(uc002hje.3 uc002hjf.4 uc010wcg.2) ENST00000542451
ENST00000592325
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLFN5 (NM_144975) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLFN5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLFN5 |
Additional cDNA sequence: AK054668.1 AK075116.1 AK303299.1 AK303632.1 AL832814.1 BC021238.1 BC125200.1 BC125201.1 BX647942.1 6 DOTS entries: DT.97770288 DT.115707 DT.91650513 DT.100754273 DT.120996492 DT.40253869 24/139 AceView cDNA sequences (see all 139): AW015128 F00314 BI766172 N21103 BQ686102 AI435399 BQ017889 AA242941 BM989559 BU161841 BU674784 BC021238 AI057502 AK054668 AA972151 BF195006 AA989712 AI269565 BM989511 AI433443 AA776469 BX495803 BM983270 AI440104
GeneLoc Exon Structure
|
Expression
for SLFN5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLFN5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTGTGATCC
About this image
See SLFN5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLFN5
SOURCE GeneReport for Unigene cluster: Hs.709347
SABiosciences Custom PCR Arrays for SLFN5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLFN5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLFN5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLFN5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLFN5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLFN5 |
Orthologs
for SLFN5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for SLFN5 (if available)
TreeFam Gene Tree for SLFN5 (if available) |
Paralogs
for SLFN5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLFN5 gene
- SLFN132 SLFN122 SLFN142 SLFN12L2 SLFN112
6 SIMAP similar genes for SLFN5 using alignment to 2 protein entries: SLFN5_HUMAN (see all proteins):FLJ31952 SLFN11 SLFN13 SLFN12 SLFN14 SLFN12L
SLFN5 for paralogs About GeneDecksing
|
Genomic Variants
for SLFN5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLFN5 (33570055 - 33600674 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SLFN5
1 CNV: 5439
Human Gene Mutation Database (HGMD): SLFN5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLFN5 |
|
Disorders
/ Diseases
for SLFN5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLFN5 for disorders About GeneDecksing
OMIM gene information: 614952
OMIM disorders: --
1  disease for SLFN5: About MalaCardsmelanoma
1 disease from the University of Copenhagen DISEASES database for SLFN5:Short bowel syndrome Export disorders for SLFN5 gene to outside databases
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Publications
for SLFN5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLFN5 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with SLFN5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Schlafen, a new family of growth regulatory genes that affect thymocyte development. (PubMed id 9846487)1, 3 Schwarz D.A....Hedrick S.M. (1998)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Purification and identification of endogenous polySUMO conjugates. (PubMed id 21252943)1 Bruderer R....Hay R.T. (2011)
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External Searches for SLFN5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLFN5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLFN5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLFN5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLFN5 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SLFN5 gene:
Search GeneIP for patents involving SLFN5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLFN5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLFN5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLFN5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for SLFN5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SLFN5 | | OriGene Custom Protein Services for SLFN5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLFN5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLFN5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLFN5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLFN5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLFN5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLFN5 |
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| | | | Search Tocris compounds for SLFN5 |
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 | | | SLFN5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLFN5 |
|  |  |  | | | | Search ThermoFisher Antibodies for SLFN5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLFN5 |
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