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Aliases for SLFN5 Gene

Aliases for SLFN5 Gene

  • Schlafen Family Member 5 2 3

External Ids for SLFN5 Gene

Previous GeneCards Identifiers for SLFN5 Gene

  • GC17U900473
  • GC17M030826
  • GC17P030595
  • GC17P033570
  • GC17P029754

Summaries for SLFN5 Gene

GeneCards Summary for SLFN5 Gene

SLFN5 (Schlafen Family Member 5) is a Protein Coding gene. An important paralog of this gene is SLFN14.

UniProtKB/Swiss-Prot for SLFN5 Gene

  • May have a role in hematopoietic cell differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLFN5 Gene

Genomics for SLFN5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLFN5 Gene

35,243,036 bp from pter
35,273,655 bp from pter
30,620 bases
Plus strand

Genomic View for SLFN5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLFN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLFN5 Gene

No data available for Regulatory Elements for SLFN5 Gene

Proteins for SLFN5 Gene

  • Protein details for SLFN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Schlafen family member 5
    Protein Accession:
    Secondary Accessions:
    • Q08AF2
    • Q8WU54
    • Q96A82

    Protein attributes for SLFN5 Gene

    891 amino acids
    Molecular mass:
    101055 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLFN5 Gene


neXtProt entry for SLFN5 Gene

Proteomics data for SLFN5 Gene at MOPED

Post-translational modifications for SLFN5 Gene

  • Ubiquitination at Lys65, Lys138, and Lys584
  • Modification sites at PhosphoSitePlus

Other Protein References for SLFN5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLFN5 Gene

Domains for SLFN5 Gene

Protein Domains for SLFN5 Gene

Suggested Antigen Peptide Sequences for SLFN5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q08AF3
  • Belongs to the Schlafen family.
genes like me logo Genes that share domains with SLFN5: view

No data available for Gene Families for SLFN5 Gene

Function for SLFN5 Gene

Molecular function for SLFN5 Gene

UniProtKB/Swiss-Prot Function: May have a role in hematopoietic cell differentiation.

Gene Ontology (GO) - Molecular Function for SLFN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SLFN5: view

Phenotypes for SLFN5 Gene

GenomeRNAi human phenotypes for SLFN5:
genes like me logo Genes that share phenotypes with SLFN5: view

Animal Model Products

CRISPR Products

miRNA for SLFN5 Gene

miRTarBase miRNAs that target SLFN5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLFN5 Gene

Localization for SLFN5 Gene

Subcellular locations from

Jensen Localization Image for SLFN5 Gene COMPARTMENTS Subcellular localization image for SLFN5 gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SLFN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SLFN5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SLFN5 Gene

Pathways for SLFN5 Gene

SuperPathways for SLFN5 Gene

No Data Available

Interacting Proteins for SLFN5 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000299977 for SLFN5 Gene via STRING

Gene Ontology (GO) - Biological Process for SLFN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SLFN5: view

No data available for Pathways by source for SLFN5 Gene

Transcripts for SLFN5 Gene

mRNA/cDNA for SLFN5 Gene

Unigene Clusters for SLFN5 Gene

Schlafen family member 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLFN5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLFN5
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLFN5 Gene

No ASD Table

Relevant External Links for SLFN5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLFN5 Gene

mRNA expression in normal human tissues for SLFN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLFN5 Gene

This gene is overexpressed in Muscle - Skeletal (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLFN5 Gene

SOURCE GeneReport for Unigene cluster for SLFN5 Gene Hs.709347

genes like me logo Genes that share expressions with SLFN5: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLFN5 Gene

Orthologs for SLFN5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLFN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLFN5 35
  • 99.33 (n)
  • 98.65 (a)
SLFN5 36
  • 99 (a)
(Canis familiaris)
Mammalia SLFN5 35
  • 80.4 (n)
  • 70.58 (a)
(Mus musculus)
Mammalia Slfn5 35
  • 73 (n)
  • 59.73 (a)
Slfn5 16
Slfn5 36
  • 58 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
(Rattus norvegicus)
Mammalia Slfn5 35
  • 71.55 (n)
  • 57.55 (a)
Species with no ortholog for SLFN5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLFN5 Gene

Gene Tree for SLFN5 (if available)
Gene Tree for SLFN5 (if available)

Paralogs for SLFN5 Gene

Paralogs for SLFN5 Gene

Selected SIMAP similar genes for SLFN5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLFN5: view

Variants for SLFN5 Gene

Sequence variations from dbSNP and Humsavar for SLFN5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs899940 -- 35,259,821(+) TCTGA(G/T)TTGCA intron-variant
rs1055636 -- 35,267,301(+) AAATT(A/C)GTAAA utr-variant-3-prime, downstream-variant-500B
rs1293224 -- 35,245,909(+) cttaa(A/G)aaact intron-variant
rs1471616 -- 35,248,101(+) accct(A/C)ctcat intron-variant
rs2127828 -- 35,252,992(+) AATTT(C/G)GGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLFN5 Gene

Variant ID Type Subtype PubMed ID
esv2422399 CNV Deletion 17116639

Relevant External Links for SLFN5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLFN5 Gene

Disorders for SLFN5 Gene

(1) University of Copenhagen DISEASES for SLFN5 Gene

genes like me logo Genes that share disorders with SLFN5: view

No data available for UniProtKB/Swiss-Prot for SLFN5 Gene

Publications for SLFN5 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Schlafen, a new family of growth regulatory genes that affect thymocyte development. (PMID: 9846487) Schwarz D.A. … Hedrick S.M. (Immunity 1998) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLFN5 Gene

Sources for SLFN5 Gene

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