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Aliases for SLFN14 Gene

Aliases for SLFN14 Gene

  • Schlafen Family Member 14 2 3 5
  • BDPLT20 3

External Ids for SLFN14 Gene

Previous GeneCards Identifiers for SLFN14 Gene

  • GC17M030901
  • GC17M033875
  • GC17M030060

Summaries for SLFN14 Gene

GeneCards Summary for SLFN14 Gene

SLFN14 (Schlafen Family Member 14) is a Protein Coding gene. An important paralog of this gene is SLFN5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLFN14 Gene

Genomics for SLFN14 Gene

Regulatory Elements for SLFN14 Gene

Enhancers for SLFN14 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLFN14 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLFN14 Gene

35,545,734 bp from pter
35,560,836 bp from pter
15,103 bases
Minus strand

Genomic View for SLFN14 Gene

Genes around SLFN14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLFN14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLFN14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLFN14 Gene

Proteins for SLFN14 Gene

  • Protein details for SLFN14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Schlafen family member 14
    Protein Accession:
    Secondary Accessions:
    • B2RTW9

    Protein attributes for SLFN14 Gene

    912 amino acids
    Molecular mass:
    103907 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLFN14 Gene


neXtProt entry for SLFN14 Gene

Proteomics data for SLFN14 Gene at MOPED

Post-translational modifications for SLFN14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLFN14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLFN14 Gene

Domains & Families for SLFN14 Gene

Gene Families for SLFN14 Gene

Protein Domains for SLFN14 Gene

Suggested Antigen Peptide Sequences for SLFN14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Schlafen family.
  • Belongs to the Schlafen family.
genes like me logo Genes that share domains with SLFN14: view

Function for SLFN14 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLFN14 Gene

Localization for SLFN14 Gene

Subcellular locations from

Jensen Localization Image for SLFN14 Gene COMPARTMENTS Subcellular localization image for SLFN14 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1
extracellular 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SLFN14 Gene

Pathways & Interactions for SLFN14 Gene

SuperPathways for SLFN14 Gene

No Data Available

Interacting Proteins for SLFN14 Gene

Gene Ontology (GO) - Biological Process for SLFN14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071286 cellular response to magnesium ion ISS --
genes like me logo Genes that share ontologies with SLFN14: view

No data available for Pathways by source and SIGNOR curated interactions for SLFN14 Gene

Drugs & Compounds for SLFN14 Gene

No Compound Related Data Available

Transcripts for SLFN14 Gene

mRNA/cDNA for SLFN14 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLFN14 Gene

Schlafen family member 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLFN14 Gene

No ASD Table

Relevant External Links for SLFN14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLFN14 Gene

mRNA expression in normal human tissues for SLFN14 Gene

mRNA differential expression in normal tissues according to GTEx for SLFN14 Gene

This gene is overexpressed in Whole Blood (x8.3), Spleen (x6.5), Lung (x4.3), and Small Intestine - Terminal Ileum (x4.2).

Protein differential expression in normal tissues from HIPED for SLFN14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (37.9), Platelet (13.5), and Serum (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLFN14 Gene

SOURCE GeneReport for Unigene cluster for SLFN14 Gene Hs.591193

genes like me logo Genes that share expression patterns with SLFN14: view

Protein tissue co-expression partners for SLFN14 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SLFN14 Gene

Orthologs for SLFN14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLFN14 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLFN14 35
  • 84.29 (n)
  • 79.01 (a)
SLFN14 36
  • 72 (a)
(Canis familiaris)
Mammalia SLFN14 35
  • 84.45 (n)
  • 78.99 (a)
SLFN14 36
  • 79 (a)
(Mus musculus)
Mammalia Slfn14 35
  • 78.53 (n)
  • 71.09 (a)
Slfn14 16
Slfn14 36
  • 70 (a)
(Pan troglodytes)
Mammalia SLFN14 35
  • 99.45 (n)
  • 99.23 (a)
SLFN14 36
  • 99 (a)
(Monodelphis domestica)
Mammalia SLFN14 36
  • 61 (a)
Species with no ortholog for SLFN14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLFN14 Gene

Gene Tree for SLFN14 (if available)
Gene Tree for SLFN14 (if available)

Paralogs for SLFN14 Gene

Paralogs for SLFN14 Gene

(6) SIMAP similar genes for SLFN14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLFN14: view

Variants for SLFN14 Gene

Sequence variations from dbSNP and Humsavar for SLFN14 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10512472 - 35,557,785(+) ATTTC(C/T)GTGAA reference, missense
rs321612 - 35,554,612(+) AAATT(C/T)GTGGA reference, missense
rs1350011 - 35,548,370(+) CAGGC(C/T)TGAAA reference, missense
rs1350010 - 35,548,339(+) CTGGA(A/C)TAAGC reference, missense
rs9907259 - 35,548,265(+) ATAAA(A/G)CAGGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLFN14 Gene

Variant ID Type Subtype PubMed ID
nsv908079 CNV Loss 21882294

Variation tolerance for SLFN14 Gene

Gene Damage Index Score: 14.13; 96.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLFN14 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLFN14 Gene

Disorders for SLFN14 Gene

Relevant External Links for SLFN14

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLFN14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLFN14 Gene

Publications for SLFN14 Gene

  1. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C. … Soranzo N. (Nature 2011) 3 48 67
  2. Schlafen, a new family of growth regulatory genes that affect thymocyte development. (PMID: 9846487) Schwarz D.A. … Hedrick S.M. (Immunity 1998) 2 3
  3. Characterization of Novel Ribosome-Associated Endoribonuclease SLFN14 from Rabbit Reticulocytes. (PMID: 25996083) Pisareva V.P. … Pisarev A.V. (Biochemistry 2015) 3
  4. SLFN14 mutations underlie thrombocytopenia with excessive bleeding and platelet secretion defects. (PMID: 26280575) Fletcher S.J. … Morgan N.V. (J. Clin. Invest. 2015) 3
  5. A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity. (PMID: 24785509) Barnett G.C. … West C.M. (Radiother Oncol 2014) 3

Products for SLFN14 Gene

Sources for SLFN14 Gene