External Ids for SLFN14 Gene
Previous GeneCards Identifiers for SLFN14 Gene
The protein encoded by this gene plays an important role in platelet formation and function. Defects in this gene are a cause of thrombocytopenia with excessive bleeding. [provided by RefSeq, Jul 2016]
GeneCards Summary for SLFN14 Gene
SLFN14 (Schlafen Family Member 14) is a Protein Coding gene. Diseases associated with SLFN14 include Bleeding Disorder, Platelet-Type 20 and Thrombocytopenia. An important paralog of this gene is SLFN13.
UniProtKB/Swiss-Prot for SLFN14 Gene
Protein SLFN14: Shows no ribosome-associated and endoribonuclease activities.
C-terminally truncated SLFN14 endoribonuclease: Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed:25996083). May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner (By similarity). Involved in correct maturation of megakaryocytes and especially important for proplatelet extension.