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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLFN13 Gene

protein-coding   GIFtS: 43
GCID: GC17M033762

Schlafen Family Member 13

  Search for SLFN13
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Schlafen Family Member 131 2
SLFN102

External Ids:    HGNC: 264811   Entrez Gene: 1468572   Ensembl: ENSG000001547607   OMIM: 6149575   UniProtKB: Q68D063   

Export aliases for SLFN13 gene to outside databases

Previous GC identifers: GC17M030786 GC17M029947


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLFN13 Gene: 
SLFN13 (schlafen family member 13) is a protein-coding gene. GO annotations related to this gene include ATP binding. An important paralog of this gene is SLFN12.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010799.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLFN13 gene promoter:
         AhR   HOXA9   HOXA9B   C/EBPbeta   RFX1   Lmo2   Roaz   Gfi-1   Meis-1b   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLFN13 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLFN13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLFN13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

SLFN13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLFN13 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M033762:  view genomic region     (about GC identifiers)

Start:
33,762,115 bp from pter      End:
33,775,856 bp from pter
Size:
13,742 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SLN13_HUMAN, Q68D06 (See protein sequence)
Recommended Name: Schlafen family member 13  
Size: 897 amino acids; 102045 Da
Sequence caution: Sequence=AK127728; Type=Frameshift; Positions=261;
Secondary accessions: E1P645 Q658M1 Q6ZS51 Q96A81
Alternative splicing: 2 isoforms:  Q68D06-1   Q68D06-2   

Explore the universe of human proteins at neXtProt for SLFN13: NX_Q68D06

Explore proteomics data for SLFN13 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q68D06

  • SLFN13 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLFN13 Protein Expression
    REFSEQ proteins: NP_653283.3  
    ENSEMBL proteins: 
     ENSP00000285013   ENSP00000434439   ENSP00000437298   ENSP00000435442   ENSP00000467426  
     ENSP00000435328   ENSP00000433181   ENSP00000467557   ENSP00000353692   ENSP00000444016  

    Human Recombinant Protein Products for SLFN13: 
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    Novus Biologicals SLFN13 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLFN13 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--

    SLFN13 for ontologies           About GeneDecksing



    SLFN13 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for SLFN13 

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    Cloud-Clone Corp. ELISAs for SLFN13 
    Cloud-Clone Corp. CLIAs for SLFN13


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR007421 ATPase_AAA-4
     IPR018647 DUF2075

    Graphical View of Domain Structure for InterPro Entry Q68D06

    ProtoNet protein and cluster: Q68D06

    UniProtKB/Swiss-Prot: SLN13_HUMAN, Q68D06
    Similarity: Belongs to the Schlafen family


    SLFN13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
         
    SLFN13 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLFN13 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLFN13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLFN13 
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    miRNA
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    Inhib. RNA
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    Clone
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    OriGene ORF clones in mouse, rat for SLFN13
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                         Customized lentivirus expression plasmids for stable overexpression of SLFN13 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLFN13


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLFN13

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLFN13 (SLN13)

    Search CenterWatch for drugs/clinical trials and news about SLFN13 / SLN13

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLFN13 gene: 
    NM_144682.5  

    Unigene Cluster for SLFN13:

    Schlafen family member 13
    Hs.462833  [show with all ESTs]
    Unigene Representative Sequence: NM_144682
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000285013(uc002hjk.1 uc010wch.1 uc002hjl.2 uc002hjm.2 uc010ctt.2)
    ENST00000526861 ENST00000530782 ENST00000534689 ENST00000533791 ENST00000532774
    ENST00000532210 ENST00000524511 ENST00000531588 ENST00000526483 ENST00000360502
    ENST00000542635
    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate SLFN13:
    hsa-miR-135b hsa-miR-150 hsa-miR-135a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLFN13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLFN13
    Clone
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    OriGene clones in human, mouse for SLFN13 (see all 9)
    OriGene ORF clones in mouse, rat for SLFN13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLFN13 (NM_144682)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLFN13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLFN13
    Sirion Biotech Customized lentivirus for stable overexpression of SLFN13 
                         Customized lentivirus expression plasmids for stable overexpression of SLFN13 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SLFN13
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLFN13
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLFN13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLFN13

    Additional mRNA sequence: 

    AK056514.1 AK074465.1 AK122750.1 AK126184.1 AK127728.1 AL832726.1 AL833747.1 BC136622.1 
    BC171771.1 CR749630.1 

    7 DOTS entries:

    DT.40292552  DT.101981872  DT.121004683  DT.91680258  DT.121004680  DT.40228655  DT.121004675 

    24/46 AceView cDNA sequences (see all 46):

    CA427765 BU679096 AI205296 AA811728 AK122750 NM_144682 AW517467 AI478308 
    AK127728 BM560787 AI538236 BQ893450 AK074465 BX476862 AI609173 BG198408 
    AK126184 BF062524 CB116559 AA969331 BX486351 BQ379854 CR749630 AK056514 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SLFN13 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                    -           -     -           -     -     -     -     -                 -                           
    SP2:                    -           -     -     -     -     -     -     -     -                 -                           
    SP3:                    -                 -                                                                                 
    SP4:                    -           -                                                                                       
    SP5:                    -           -     -                       -     -     -                                             


    ECgene alternative splicing isoforms for SLFN13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLFN13 expression in normal human tissues (normalized intensities)      SLFN13 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCACACA
    SLFN13 Expression
    About this image


    SLFN13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Epithelium (Respiratory System)    fully expand to see all 2 entries
             bronchial epithelial cells   
     
     Lung (Respiratory System)
             trachea   
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme

    See SLFN13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLFN13

    SOURCE GeneReport for Unigene cluster: Hs.462833
        SABiosciences Custom PCR Arrays for SLFN13
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLFN13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for SLFN13 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slfn85
    Slfn91
    schlafen 85
    schlafen 91
    72.69(n)1
    64.41(a)1
      11 (50.30 cM)5
    2378861  NM_172796.21  NP_766384.21 
     830021585 


    ENSEMBL Gene Tree for SLFN13 (if available)
    TreeFam Gene Tree for SLFN13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLFN13 gene
    SLFN122  SLFN142  SLFN12L2  SLFN112  SLFN52  
    6 SIMAP similar genes for SLFN13 using alignment to 6 protein entries:     SLN13_HUMAN (see all proteins):
    FLJ31952    SLFN11    SLFN5    SLFN12    SLFN14    SLFN12L

    SLFN13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/479 SNPs in SLFN13 are shown (see all 479)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1147859351,2
    F--33761619(+) CTAGCG/ACAGGC 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs773509741,2
    C--33761648(+) TCTAT-/AATCCC 1 -- ds50010--------
    rs2020116411,2
    C--33761884(+) AAGGG-/ATTCT 
            
    ATCTC
    1 -- ds50010--------
    rs1479193861,2
    C--33761894(+) ATCTC-/AAAAAA
    AGAAAAAGA
    AAAAA
    1 -- ds50010--------
    rs1448792991,2
    --33761948(+) TGCAGG/TGATTT 1 -- ds50010--------
    rs72130691,2
    C--33761988(+) AGAAAC/GAAAAG 1 -- ds50010--------
    rs26718261,2
    C,H--33761995(-) TTAATC/GTCTTT 1 -- ds500112Minor allele frequency- G:0.00NA WA CSA EA 263
    rs562890191,2
    C,F--33762036(+) GGCATG/AACATA 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1161061231,2
    C,F--33762131(+) TTATGT/CTTTTA 1 -- ut311Minor allele frequency- C:0.02WA 118
    rs790514841,2
    C--33762220(+) TTACAC/TGGCTA 1 -- ut313Minor allele frequency- T:0.08CSA WA EA 240

    HapMap Linkage Disequilibrium report for SLFN13 (33762115 - 33775856 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SLFN13:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2715869CNV Deletion23290073
    dgv365n27CNV Loss19166990
    nsv908077CNV Loss21882294
    dgv3142n71CNV Gain21882294
    nsv457728CNV Gain19166990
    nsv515566CNV Gain+Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLFN13
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLFN13 for disorders           About MalaCards
    OMIM gene information: 614957    OMIM disorders: --


    SLFN13 for disorders           About GeneDecksing


    Export disorders for SLFN13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLFN13 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SLFN13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Schlafen, a new family of growth regulatory genes that affect thymocyte development. (PubMed id 9846487)1, 3 Schwarz D.A....Hedrick S.M. (1998)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    4. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1 Wiemann S.... Poustka A. (2001)
    9. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (2000)
    10. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 146857 HGNC: 26481 AceView: FLJ31952 Ensembl:ENSG00000154760 euGenes: HUgn146857
    ECgene: SLFN13 H-InvDB: SLFN13

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLFN13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLFN13 gene:
    Search GeneIP for patents involving SLFN13

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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