Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLFN13 Gene

Aliases for SLFN13 Gene

  • Schlafen Family Member 13 2 3 5
  • SLFN10 3

External Ids for SLFN13 Gene

Previous GeneCards Identifiers for SLFN13 Gene

  • GC17M030786
  • GC17M033762
  • GC17M029947

Summaries for SLFN13 Gene

GeneCards Summary for SLFN13 Gene

SLFN13 (Schlafen Family Member 13) is a Protein Coding gene. An important paralog of this gene is SLFN5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLFN13 Gene

Genomics for SLFN13 Gene

Regulatory Elements for SLFN13 Gene

Promoters for SLFN13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLFN13 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLFN13 Gene

35,435,096 bp from pter
35,449,008 bp from pter
13,913 bases
Minus strand

Genomic View for SLFN13 Gene

Genes around SLFN13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLFN13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLFN13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLFN13 Gene

Proteins for SLFN13 Gene

  • Protein details for SLFN13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Schlafen family member 13
    Protein Accession:
    Secondary Accessions:
    • E1P645
    • Q658M1
    • Q6ZS51
    • Q96A81

    Protein attributes for SLFN13 Gene

    897 amino acids
    Molecular mass:
    102045 Da
    Quaternary structure:
    No Data Available
    • Sequence=AK127728; Type=Frameshift; Positions=261; Evidence={ECO:0000305};

    Alternative splice isoforms for SLFN13 Gene


neXtProt entry for SLFN13 Gene

Proteomics data for SLFN13 Gene at MOPED

Post-translational modifications for SLFN13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLFN13 Gene

Domains & Families for SLFN13 Gene

Gene Families for SLFN13 Gene

Protein Domains for SLFN13 Gene

Suggested Antigen Peptide Sequences for SLFN13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Schlafen family.
  • Belongs to the Schlafen family.
genes like me logo Genes that share domains with SLFN13: view

Function for SLFN13 Gene

Phenotypes for SLFN13 Gene

GenomeRNAi human phenotypes for SLFN13:
genes like me logo Genes that share phenotypes with SLFN13: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLFN13 Gene

Localization for SLFN13 Gene

Subcellular locations from

Jensen Localization Image for SLFN13 Gene COMPARTMENTS Subcellular localization image for SLFN13 gene
Compartment Confidence
cytosol 3
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SLFN13 Gene

Pathways & Interactions for SLFN13 Gene

SuperPathways for SLFN13 Gene

No Data Available

Interacting Proteins for SLFN13 Gene

Gene Ontology (GO) - Biological Process for SLFN13 Gene


No data available for Pathways by source and SIGNOR curated interactions for SLFN13 Gene

Drugs & Compounds for SLFN13 Gene

No Compound Related Data Available

Transcripts for SLFN13 Gene

Unigene Clusters for SLFN13 Gene

Schlafen family member 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLFN13 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - -
SP5: - - - - - -
SP6: - - -
SP7: - -
SP8: -

Relevant External Links for SLFN13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLFN13 Gene

mRNA expression in normal human tissues for SLFN13 Gene

mRNA differential expression in normal tissues according to GTEx for SLFN13 Gene

This gene is overexpressed in Whole Blood (x4.2) and Minor Salivary Gland (x4.0).

Protein differential expression in normal tissues from HIPED for SLFN13 Gene

This gene is overexpressed in Adipocyte (51.6), Platelet (8.7), and Heart (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SLFN13 Gene

SOURCE GeneReport for Unigene cluster for SLFN13 Gene Hs.462833

genes like me logo Genes that share expression patterns with SLFN13: view

Protein tissue co-expression partners for SLFN13 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SLFN13 Gene

Orthologs for SLFN13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLFN13 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Slfn9 35
  • 72.65 (n)
  • 64.33 (a)
Slfn9 16
Slfn8 36
  • 61 (a)
Slfn9 36
  • 62 (a)
(Pan troglodytes)
Mammalia SLFN13 35
  • 99.22 (n)
  • 98.66 (a)
SLFN13 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Slfn13 35
  • 71.26 (n)
  • 61.69 (a)
(Bos Taurus)
Mammalia -- 36
  • 66 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 53 (a)
Species with no ortholog for SLFN13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLFN13 Gene

Gene Tree for SLFN13 (if available)
Gene Tree for SLFN13 (if available)

Paralogs for SLFN13 Gene

Paralogs for SLFN13 Gene

(6) SIMAP similar genes for SLFN13 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLFN13: view

Variants for SLFN13 Gene

Sequence variations from dbSNP and Humsavar for SLFN13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs12943866 - 35,445,670(+) AGTGA(C/T)TTGCC intron-variant, reference, missense
rs7216628 - 35,445,533(+) ACACG(C/T)GGCCC intron-variant, reference, missense
rs3744371 - 35,441,335(+) AGTTT(C/T)CCGGG reference, missense
rs16970912 - 35,442,187(+) AGAAA(A/G/T)GTCGC reference, missense
rs11657183 - 35,441,364(+) TTCTA(A/T)CACTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLFN13 Gene

Variant ID Type Subtype PubMed ID
nsv515566 CNV Gain+Loss 19592680
nsv908077 CNV Loss 21882294
dgv3142n71 CNV Gain 21882294
esv2715869 CNV Deletion 23290073
dgv365n27 CNV Loss 19166990
nsv457728 CNV Gain 19166990

Variation tolerance for SLFN13 Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.13; 84.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLFN13 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLFN13 Gene

Disorders for SLFN13 Gene

Relevant External Links for SLFN13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLFN13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLFN13 Gene

Publications for SLFN13 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Schlafen, a new family of growth regulatory genes that affect thymocyte development. (PMID: 9846487) Schwarz D.A. … Hedrick S.M. (Immunity 1998) 2 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3
  5. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3

Products for SLFN13 Gene

Sources for SLFN13 Gene

Back to Top