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Aliases for SLFN13 Gene

Aliases for SLFN13 Gene

  • Schlafen Family Member 13 2 3
  • SLFN10 3

External Ids for SLFN13 Gene

Summaries for SLFN13 Gene

GeneCards Summary for SLFN13 Gene

SLFN13 (Schlafen Family Member 13) is a Protein Coding gene. An important paralog of this gene is SLFN14.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLFN13 Gene

Genomics for SLFN13 Gene

Genomic Location for SLFN13 Gene

Start:
35,435,096 bp from pter
End:
35,448,837 bp from pter
Size:
13,742 bases
Orientation:
Minus strand

Genomic View for SLFN13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLFN13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLFN13 Gene

Regulatory Elements for SLFN13 Gene

Proteins for SLFN13 Gene

  • Protein details for SLFN13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68D06-SLN13_HUMAN
    Recommended name:
    Schlafen family member 13
    Protein Accession:
    Q68D06
    Secondary Accessions:
    • E1P645
    • Q658M1
    • Q6ZS51
    • Q96A81

    Protein attributes for SLFN13 Gene

    Size:
    897 amino acids
    Molecular mass:
    102045 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK127728; Type=Frameshift; Positions=261; Evidence={ECO:0000305};

    Alternative splice isoforms for SLFN13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLFN13 Gene

Proteomics data for SLFN13 Gene at MOPED

Post-translational modifications for SLFN13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLFN13 Gene

Domains for SLFN13 Gene

Protein Domains for SLFN13 Gene

UniProtKB/Swiss-Prot:

SLN13_HUMAN
Family:
  • Belongs to the Schlafen family.:
    • Q68D06
genes like me logo Genes that share domains with SLFN13: view

No data available for Gene Families for SLFN13 Gene

Function for SLFN13 Gene

Gene Ontology (GO) - Molecular Function for SLFN13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SLFN13: view

miRNA for SLFN13 Gene

miRTarBase miRNAs that target SLFN13

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLFN13 Gene

Localization for SLFN13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLFN13 Gene COMPARTMENTS Subcellular localization image for SLFN13 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SLFN13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
genes like me logo Genes that share ontologies with SLFN13: view

Pathways for SLFN13 Gene

SuperPathways for SLFN13 Gene

No Data Available

Interacting Proteins for SLFN13 Gene

Gene Ontology (GO) - Biological Process for SLFN13 Gene

None

No data available for Pathways by source for SLFN13 Gene

Transcripts for SLFN13 Gene

Unigene Clusters for SLFN13 Gene

Schlafen family member 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLFN13 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - -
SP5: - - - - - -
SP6: - - -
SP7: - -
SP8: -
SP9:

Relevant External Links for SLFN13 Gene

GeneLoc Exon Structure for
SLFN13
ECgene alternative splicing isoforms for
SLFN13

Expression for SLFN13 Gene

mRNA expression in normal human tissues for SLFN13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLFN13 Gene

This gene is overexpressed in Whole Blood (4.2) and Minor Salivary Gland (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLFN13 Gene

SOURCE GeneReport for Unigene cluster for SLFN13 Gene Hs.462833

genes like me logo Genes that share expressions with SLFN13: view

Orthologs for SLFN13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLFN13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLFN13 36
  • 99.22 (n)
  • 98.66 (a)
SLFN13 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 66 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Slfn8 16
Slfn8 37
  • 61 (a)
ManyToMany
Slfn9 36
  • 72.65 (n)
  • 64.33 (a)
Slfn9 37
  • 62 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 53 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slfn13 36
  • 71.26 (n)
  • 61.69 (a)
Species with no ortholog for SLFN13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLFN13 Gene

ENSEMBL:
Gene Tree for SLFN13 (if available)
TreeFam:
Gene Tree for SLFN13 (if available)

Paralogs for SLFN13 Gene

Paralogs for SLFN13 Gene

Selected SIMAP similar genes for SLFN13 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLFN13: view

Variants for SLFN13 Gene

Sequence variations from dbSNP and Humsavar for SLFN13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1822403 -- 35,441,180(-) CTGGA(C/T)TACTT reference, synonymous-codon
rs2034097 -- 35,435,298(-) TCCCC(A/G)CAAAA utr-variant-3-prime
rs2376263 -- 35,436,659(-) TTCCA(C/T)AGAAG utr-variant-3-prime
rs2681066 -- 35,441,457(+) ATATT(A/G)CCACA intron-variant
rs3056654 -- 35,439,480(-) aagaa(-/GAA/GAAA)aaaaa utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLFN13 Gene

Variant ID Type Subtype PubMed ID
nsv515566 CNV Gain+Loss 19592680
nsv908077 CNV Loss 21882294
dgv3142n71 CNV Gain 21882294
esv2715869 CNV Deletion 23290073
dgv365n27 CNV Loss 19166990
nsv457728 CNV Gain 19166990

Relevant External Links for SLFN13 Gene

HapMap Linkage Disequilibrium report
SLFN13

Disorders for SLFN13 Gene

No disorders were found for SLFN13 Gene.

No data available for UniProtKB/Swiss-Prot for SLFN13 Gene

Publications for SLFN13 Gene

  1. Schlafen, a new family of growth regulatory genes that affect thymocyte development. (PMID: 9846487) Schwarz D.A. … Hedrick S.M. (Immunity 1998) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for SLFN13 Gene

Sources for SLFN13 Gene

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