SLFN13 Gene
protein-coding GIFtS: 41
GCID: GC17M033762
|
|
schlafen family member 13
| |
Aliases
for SLFN13 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Schlafen Family Member 131 2 | | FLJ319521 | | SLFN102 |
Export aliases for SLFN13 gene to outside databasesPrevious GC identifers: GC17M030786 GC17M029947 |
Summaries
for SLFN13 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SLFN13 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLFN13 gene promoter:
AhR HOXA9 HOXA9B C/EBPbeta RFX1 Lmo2 Roaz Gfi-1 Meis-1b Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLFN13
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLFN13 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q12SLFN13 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M033762: view genomic region
(about GC identifiers)
Start:
|
33,762,115 bp from pter |
End:
|
33,775,856 bp from pter |
Size:
|
13,742 bases |
Orientation:
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minus strand |
|
Proteins
for SLFN13 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SLN13_HUMAN, Q68D06 (See
protein sequence)Recommended Name: Schlafen family member 13 Size: 897 amino acids; 102045 Da
Sequence caution: Sequence=AK127728; Type=Frameshift; Positions=261;
Secondary accessions: E1P645 Q658M1 Q6ZS51 Q96A81Alternative splicing: 2 isoforms: Q68D06-1 Q68D06-2 Explore the universe of human proteins at neXtProt for SLFN13: NX_Q68D06
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q68D06
SLFN13 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653283.3
ENSEMBL proteins: ENSP00000285013 ENSP00000434439 ENSP00000437298 ENSP00000435442 ENSP00000467426 ENSP00000435328 ENSP00000433181 ENSP00000467557 ENSP00000353692 ENSP00000444016
Human Recombinant Protein Products for SLFN13:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IDA | -- |
SLFN13 for ontologies About GeneDecksing
SLFN13 Antibody Products:
Assay Products for SLFN13: |
Protein
Domains /
Families
for SLFN13 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLFN13 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q68D06ProtoNet protein and cluster: Q68D06 UniProtKB/Swiss-Prot: SLN13_HUMAN, Q68D06Similarity: Belongs to the Schlafen family |
Function
for SLFN13 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- |
SLFN13 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN13 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN13
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLFN13 (NM_144682) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLFN13 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLFN13 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLFN13 |
|
Pathways & Interactions
for SLFN13 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLFN13
|
Drugs & Compounds
for SLFN13 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLFN13
Search CenterWatch for drugs/clinical trials and news about SLFN13 / SLN13
|
Transcripts
for SLFN13 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLFN13 gene: NM_144682.5 Unigene Cluster for SLFN13: Schlafen family member 13 Hs.462833 [show with all ESTs]Unigene Representative Sequence: NM_14468212 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000285013(uc002hjk.1 uc010wch.1 uc002hjl.2 uc002hjm.2 uc010ctt.2)
ENST00000526861 ENST00000530782 ENST00000534689 ENST00000533791 ENST00000532774
ENST00000532210 ENST00000524511 ENST00000531588 ENST00000526483 ENST00000360502
ENST00000542635
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN13 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN13
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLFN13 (NM_144682) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLFN13 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLFN13 |
Additional cDNA sequence: AK056514.1 AK074465.1 AK122750.1 AK126184.1 AK127728.1 AL832726.1 AL833747.1 BC136622.1 BC171771.1 CR749630.1 7 DOTS entries: DT.40292552 DT.101981872 DT.121004683 DT.91680258 DT.121004680 DT.40228655 DT.121004675 24/46 AceView cDNA sequences (see all 46): AI538236 AW517467 BM560787 BU679096 AA811728 AI478308 AK127728 BQ893450 AK074465 CA427765 AI205296 NM_144682 BX476862 AK122750 BM914096 BX486351 CB116559 CR749630 CD653722 BM988117 BQ379854 AA969331 BF062524 AL712648
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SLFN13 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c |
|---|
|
| SP1: | | | | | | | - | | | | - | | - | | | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | - | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SLFN13
|
Expression
for SLFN13 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLFN13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAGCACACA
About this image
See SLFN13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLFN13
SOURCE GeneReport for Unigene cluster: Hs.462833
SABiosciences Custom PCR Arrays for SLFN13
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLFN13
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLFN13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLFN13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLFN13 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLFN13 |
Orthologs
for SLFN13 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for SLFN13 (if available)
TreeFam Gene Tree for SLFN13 (if available) |
Paralogs
for SLFN13 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLFN13 gene
- SLFN122 SLFN142 SLFN12L2 SLFN112 SLFN52
6 SIMAP similar genes for SLFN13 using alignment to 6 protein entries: SLN13_HUMAN (see all proteins):FLJ31952 SLFN11 SLFN5 SLFN12 SLFN14 SLFN12L
SLFN13 for paralogs About GeneDecksing
|
Genomic Variants
for SLFN13 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLFN13 (33762115 - 33775856 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SLFN13
2 CNVs: 49846 53288 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLFN13 |
|
Disorders
/ Diseases
for SLFN13 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SLFN13 for disorders About MalaCards
SLFN13 for disorders About GeneDecksing
OMIM gene information: 614957
OMIM disorders: --
Export disorders for SLFN13 gene to outside databases
|
Publications
for SLFN13 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLFN13 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLFN13) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Schlafen, a new family of growth regulatory genes that affect thymocyte development. (PubMed id 9846487)1, 3 Schwarz D.A....Hedrick S.M. (1998)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1 Wiemann S.... Poustka A. (2001)
- Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (2000)
- DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (2000)
|
External Searches for SLFN13 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLFN13 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLFN13 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLFN13 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLFN13 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLFN13 gene:
Search GeneIP for patents involving SLFN13
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLFN13 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLFN13 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLFN13 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLFN13 | | | OriGene Protein Over-expression Lysate for SLFN13 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLFN13 | | OriGene 3'-UTR Clone for SLFN13 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN13 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN13 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SLFN13 | | OriGene Custom Protein Services for SLFN13 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLFN13 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLFN13 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLFN13 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLFN13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLFN13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLFN13 |
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| | | | Search Tocris compounds for SLFN13 |
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 | | | SLFN13 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLFN13 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for SLFN13 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLFN13 |
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