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Aliases for SLFN12L Gene

Aliases for SLFN12L Gene

  • Schlafen Family Member 12-Like 2 3
  • SLFN5 4

External Ids for SLFN12L Gene

Previous GeneCards Identifiers for SLFN12L Gene

  • GC17M030823
  • GC17M033801
  • GC17M033791

Summaries for SLFN12L Gene

GeneCards Summary for SLFN12L Gene

SLFN12L (Schlafen Family Member 12-Like) is a Protein Coding gene. An important paralog of this gene is SLFN14.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLFN12L Gene

Genomics for SLFN12L Gene

Regulatory Elements for SLFN12L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLFN12L Gene

35,464,249 bp from pter
35,537,861 bp from pter
73,613 bases
Minus strand

Genomic View for SLFN12L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLFN12L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLFN12L Gene

Proteins for SLFN12L Gene

  • Protein details for SLFN12L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Schlafen family member 12-like
    Protein Accession:
    Secondary Accessions:
    • F5H6G3

    Protein attributes for SLFN12L Gene

    588 amino acids
    Molecular mass:
    67096 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAD80167.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLFN12L Gene


neXtProt entry for SLFN12L Gene

Proteomics data for SLFN12L Gene at MOPED

Post-translational modifications for SLFN12L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLFN12L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLFN12L Gene

Domains for SLFN12L Gene

Gene Families for SLFN12L Gene

Protein Domains for SLFN12L Gene

Suggested Antigen Peptide Sequences for SLFN12L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Schlafen family.
  • Belongs to the Schlafen family.
genes like me logo Genes that share domains with SLFN12L: view

Function for SLFN12L Gene

Gene Ontology (GO) - Molecular Function for SLFN12L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SLFN12L: view

Phenotypes for SLFN12L Gene

MGI mutant phenotypes for SLFN12L:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SLFN12L: view

miRNA for SLFN12L Gene

miRTarBase miRNAs that target SLFN12L

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLFN12L

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLFN12L Gene

Localization for SLFN12L Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLFN12L Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLFN12L Gene COMPARTMENTS Subcellular localization image for SLFN12L gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLFN12L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLFN12L: view

Pathways for SLFN12L Gene

SuperPathways for SLFN12L Gene

No Data Available

Interacting Proteins for SLFN12L Gene

Gene Ontology (GO) - Biological Process for SLFN12L Gene


No data available for Pathways by source for SLFN12L Gene

Transcripts for SLFN12L Gene

mRNA/cDNA for SLFN12L Gene

(3) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLFN12L Gene

Schlafen family member 12-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLFN12L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLFN12L Gene

No ASD Table

Relevant External Links for SLFN12L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLFN12L Gene

mRNA expression in normal human tissues for SLFN12L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLFN12L Gene

This gene is overexpressed in Whole Blood (8.2).

Protein differential expression in normal tissues for SLFN12L Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLFN12L Gene

SOURCE GeneReport for Unigene cluster for SLFN12L Gene Hs.447559

genes like me logo Genes that share expressions with SLFN12L: view

Expression partners for SLFN12L Gene

* - Elite partner

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLFN12L Gene

Orthologs for SLFN12L Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLFN12L Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Slfn4 35
  • 66.87 (n)
  • 50.3 (a)
Slfn3 16
Slfn1 36
  • 48 (a)
Slfn2 36
  • 50 (a)
Slfn3 36
  • 41 (a)
Slfn4 36
  • 39 (a)
(Pan troglodytes)
Mammalia SLFN12L 35
  • 98.55 (n)
  • 97.56 (a)
SLFN12L 36
  • 89 (a)
(Bos Taurus)
Mammalia -- 36
  • 66 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 15 (a)
Species with no ortholog for SLFN12L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLFN12L Gene

Gene Tree for SLFN12L (if available)
Gene Tree for SLFN12L (if available)

Paralogs for SLFN12L Gene

Paralogs for SLFN12L Gene

(5) SIMAP similar genes for SLFN12L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLFN12L: view

Variants for SLFN12L Gene

Sequence variations from dbSNP and Humsavar for SLFN12L Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2083820 -- 35,482,880(-) tgcag(C/T)cccag intron-variant
rs2304967 - 35,478,161(-) TCCAG(C/G)AAGTA reference, missense
rs2304968 - 35,478,131(-) GAGTT(A/G)TCCTC reference, missense
rs3744372 - 35,475,137(+) TCAAG(G/T)AGAAG reference, missense
rs4796087 -- 35,485,779(+) ttggt(A/G)gactt intron-variant

Relevant External Links for SLFN12L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLFN12L Gene

Disorders for SLFN12L Gene

Relevant External Links for SLFN12L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SLFN12L Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SLFN12L Gene

Publications for SLFN12L Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4
  2. Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control. (PMID: 20045101) Ferreira M.A. … Martin N.G. (Am. J. Hum. Genet. 2010) 3 48
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Genome-wide association scan of trait depression. (PMID: 20800221) Terracciano A. … Costa P.T. (Biol. Psychiatry 2010) 3 48
  5. Schlafen, a new family of growth regulatory genes that affect thymocyte development. (PMID: 9846487) Schwarz D.A. … Hedrick S.M. (Immunity 1998) 2 3

Products for SLFN12L Gene

Sources for SLFN12L Gene

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