Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLFN12L Gene

Aliases for SLFN12L Gene

  • Schlafen Family Member 12 Like 2 3
  • Schlafen Family Member 12-Like 2 5
  • SLFN5 4

External Ids for SLFN12L Gene

Previous GeneCards Identifiers for SLFN12L Gene

  • GC17M030823
  • GC17M033801
  • GC17M033791

Summaries for SLFN12L Gene

GeneCards Summary for SLFN12L Gene

SLFN12L (Schlafen Family Member 12 Like) is a Protein Coding gene. An important paralog of this gene is SLFN5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLFN12L Gene

Genomics for SLFN12L Gene

Regulatory Elements for SLFN12L Gene

Enhancers for SLFN12L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLFN12L on UCSC Golden Path with GeneCards custom track

Promoters for SLFN12L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLFN12L on UCSC Golden Path with GeneCards custom track

Genomic Location for SLFN12L Gene

Chromosome:
17
Start:
35,464,249 bp from pter
End:
35,537,861 bp from pter
Size:
73,613 bases
Orientation:
Minus strand

Genomic View for SLFN12L Gene

Genes around SLFN12L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLFN12L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLFN12L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLFN12L Gene

Proteins for SLFN12L Gene

  • Protein details for SLFN12L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IEE8-SN12L_HUMAN
    Recommended name:
    Schlafen family member 12-like
    Protein Accession:
    Q6IEE8
    Secondary Accessions:
    • F5H6G3

    Protein attributes for SLFN12L Gene

    Size:
    588 amino acids
    Molecular mass:
    67096 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD80167.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLFN12L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLFN12L Gene

Proteomics data for SLFN12L Gene at MOPED

Post-translational modifications for SLFN12L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLFN12L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLFN12L Gene

Domains & Families for SLFN12L Gene

Gene Families for SLFN12L Gene

Protein Domains for SLFN12L Gene

Suggested Antigen Peptide Sequences for SLFN12L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IEE8

UniProtKB/Swiss-Prot:

SN12L_HUMAN :
  • Belongs to the Schlafen family.
Family:
  • Belongs to the Schlafen family.
genes like me logo Genes that share domains with SLFN12L: view

Function for SLFN12L Gene

miRNA for SLFN12L Gene

miRTarBase miRNAs that target SLFN12L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLFN12L Gene

Localization for SLFN12L Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLFN12L Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLFN12L Gene COMPARTMENTS Subcellular localization image for SLFN12L gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SLFN12L Gene

Pathways & Interactions for SLFN12L Gene

SuperPathways for SLFN12L Gene

No Data Available

Interacting Proteins for SLFN12L Gene

Gene Ontology (GO) - Biological Process for SLFN12L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLFN12L Gene

Drugs & Compounds for SLFN12L Gene

No Compound Related Data Available

Transcripts for SLFN12L Gene

mRNA/cDNA for SLFN12L Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLFN12L Gene

Schlafen family member 12-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLFN12L Gene

No ASD Table

Relevant External Links for SLFN12L Gene

GeneLoc Exon Structure for
SLFN12L
ECgene alternative splicing isoforms for
SLFN12L

Expression for SLFN12L Gene

mRNA expression in normal human tissues for SLFN12L Gene

mRNA differential expression in normal tissues according to GTEx for SLFN12L Gene

This gene is overexpressed in Whole Blood (x8.2).

Protein differential expression in normal tissues from HIPED for SLFN12L Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLFN12L Gene



SOURCE GeneReport for Unigene cluster for SLFN12L Gene Hs.447559

genes like me logo Genes that share expression patterns with SLFN12L: view

Protein tissue co-expression partners for SLFN12L Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SLFN12L Gene

Orthologs for SLFN12L Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLFN12L Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Slfn4 35
  • 66.87 (n)
  • 50.3 (a)
Slfn4 16
Slfn1 36
  • 48 (a)
ManyToMany
Slfn2 36
  • 50 (a)
ManyToMany
Slfn3 36
  • 41 (a)
ManyToMany
Slfn4 36
  • 39 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia SLFN12L 35
  • 98.55 (n)
  • 97.56 (a)
SLFN12L 36
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 66 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 15 (a)
OneToMany
Species with no ortholog for SLFN12L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLFN12L Gene

ENSEMBL:
Gene Tree for SLFN12L (if available)
TreeFam:
Gene Tree for SLFN12L (if available)

Paralogs for SLFN12L Gene

Paralogs for SLFN12L Gene

(5) SIMAP similar genes for SLFN12L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLFN12L: view

Variants for SLFN12L Gene

Sequence variations from dbSNP and Humsavar for SLFN12L Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs12451679 - 35,479,527(+) CAGTC(A/G)AGAAG reference, missense
rs2304967 - 35,478,161(-) TCCAG(C/G)AAGTA reference, missense
rs2304968 - 35,478,131(-) GAGTT(A/G)TCCTC reference, missense
rs3744372 - 35,475,137(+) TCAAG(G/T)AGAAG reference, missense
rs1838148 -- 35,492,382(-) GGCCC(A/G)GGAAG upstream-variant-2KB

Variation tolerance for SLFN12L Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.04; 84.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLFN12L Gene

HapMap Linkage Disequilibrium report
SLFN12L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLFN12L Gene

Disorders for SLFN12L Gene

Relevant External Links for SLFN12L

Genetic Association Database (GAD)
SLFN12L
Human Genome Epidemiology (HuGE) Navigator
SLFN12L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLFN12L

No disorders were found for SLFN12L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLFN12L Gene

Publications for SLFN12L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Schlafen, a new family of growth regulatory genes that affect thymocyte development. (PMID: 9846487) Schwarz D.A. … Hedrick S.M. (Immunity 1998) 2 3
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  4. Genome-wide association scan of trait depression. (PMID: 20800221) Terracciano A. … Costa P.T. (Biol. Psychiatry 2010) 3
  5. Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control. (PMID: 20045101) Ferreira M.A. … Martin N.G. (Am. J. Hum. Genet. 2010) 3

Products for SLFN12L Gene

Sources for SLFN12L Gene

Content