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Aliases for SLFN12 Gene

Aliases for SLFN12 Gene

  • Schlafen Family Member 12 2 3 5
  • SLFN3 3

External Ids for SLFN12 Gene

Previous GeneCards Identifiers for SLFN12 Gene

  • GC17M030763
  • GC17M033738
  • GC17M029923

Summaries for SLFN12 Gene

GeneCards Summary for SLFN12 Gene

SLFN12 (Schlafen Family Member 12) is a Protein Coding gene. An important paralog of this gene is SLFN12L.

Additional gene information for SLFN12 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLFN12 Gene

Genomics for SLFN12 Gene

Regulatory Elements for SLFN12 Gene

Enhancers for SLFN12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H035431 0.9 ENCODE 31 +0.2 218 3.6 ATF1 ATF7 FOS RUNX3 JUNB ZNF518A MAFF SMARCA4 MYNN SP7 SLFN12 ENSG00000267648 ZNF830 LIG3 ENSG00000267547 SLFN13 ENSG00000267102
GH17H035372 1 ENCODE 18.7 +59.3 59250 2.6 HDGF GLI4 ZNF2 ZNF121 GLIS2 ZNF416 ZNF143 ATF7 SP3 REST SLFN11 LIG3 SLFN12 ZNF830 ENSG00000267102 ENSG00000267648 SLFN14 RFFL E2F3P1 SLFN5
GH17H035367 0.9 Ensembl ENCODE 9.9 +65.1 65054 2 HDGF SP2 MAX ELF1 ZIC2 SP1 PRDM10 MYC SPI1 SLFN12 LOC105371933 GC17P035345
GH17H035529 1.1 FANTOM5 ENCODE dbSUPER 4.9 -97.9 -97871 3.6 CTCF ZNF146 ZNF366 PRDM1 SLFN5 AP2B1 SLFN13 NLE1 SLFN12L RASL10B SLFN12 CCL5 SLFN11 RFFL
GH17H035981 0.9 ENCODE 5.1 -548.7 -548735 1.4 ELF3 FOXA2 ARID4B THRB ZSCAN9 RAD21 RARA YY1 MIXL1 SP5 SLFN12 CCL16 GC17M036084
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLFN12 on UCSC Golden Path with GeneCards custom track

Promoters for SLFN12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000093481 683 1601 CTCF RB1 JUN INSM2 MAX RFX5 HIC1 ZBTB48 POLR2A EED

Genomic Locations for SLFN12 Gene

Genomic Locations for SLFN12 Gene
chr17:35,409,650-35,433,283
(GRCh38/hg38)
Size:
23,634 bases
Orientation:
Minus strand
chr17:33,738,079-33,760,302
(GRCh37/hg19)

Genomic View for SLFN12 Gene

Genes around SLFN12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLFN12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLFN12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLFN12 Gene

Proteins for SLFN12 Gene

  • Protein details for SLFN12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYM2-SLN12_HUMAN
    Recommended name:
    Schlafen family member 12
    Protein Accession:
    Q8IYM2
    Secondary Accessions:
    • A8K711
    • Q9NP47

    Protein attributes for SLFN12 Gene

    Size:
    578 amino acids
    Molecular mass:
    66972 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLFN12 Gene

Post-translational modifications for SLFN12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLFN12 Gene

Domains & Families for SLFN12 Gene

Gene Families for SLFN12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SLFN12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLFN12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYM2

UniProtKB/Swiss-Prot:

SLN12_HUMAN :
  • Belongs to the Schlafen family.
Family:
  • Belongs to the Schlafen family.
genes like me logo Genes that share domains with SLFN12: view

Function for SLFN12 Gene

Gene Ontology (GO) - Molecular Function for SLFN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SLFN12: view

Phenotypes for SLFN12 Gene

GenomeRNAi human phenotypes for SLFN12:
genes like me logo Genes that share phenotypes with SLFN12: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLFN12 Gene

Localization for SLFN12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLFN12 gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SLFN12 Gene

Pathways & Interactions for SLFN12 Gene

SuperPathways for SLFN12 Gene

No Data Available

Interacting Proteins for SLFN12 Gene

Selected Interacting proteins: Q8IYM2-SLN12_HUMAN for SLFN12 Gene via MINT IID

Gene Ontology (GO) - Biological Process for SLFN12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLFN12 Gene

Drugs & Compounds for SLFN12 Gene

No Compound Related Data Available

Transcripts for SLFN12 Gene

Unigene Clusters for SLFN12 Gene

Schlafen family member 12:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLFN12 Gene

No ASD Table

Relevant External Links for SLFN12 Gene

GeneLoc Exon Structure for
SLFN12
ECgene alternative splicing isoforms for
SLFN12

Expression for SLFN12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLFN12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLFN12 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLFN12 Gene



Protein tissue co-expression partners for SLFN12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLFN12 Gene:

SLFN12

SOURCE GeneReport for Unigene cluster for SLFN12 Gene:

Hs.663548

Evidence on tissue expression from TISSUES for SLFN12 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SLFN12: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLFN12 Gene

Orthologs for SLFN12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLFN12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLFN12 33 34
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia SLFN12L 33
  • 76.83 (n)
-- 34
  • 67 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SLFN12 33
  • 76.4 (n)
rat
(Rattus norvegicus)
Mammalia Slfn4 33
  • 66.12 (n)
mouse
(Mus musculus)
Mammalia Slfn1 34
  • 50 (a)
ManyToMany
Slfn2 34
  • 49 (a)
ManyToMany
Slfn3 34
  • 43 (a)
ManyToMany
Slfn4 34
  • 40 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 16 (a)
OneToMany
Species where no ortholog for SLFN12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLFN12 Gene

ENSEMBL:
Gene Tree for SLFN12 (if available)
TreeFam:
Gene Tree for SLFN12 (if available)

Paralogs for SLFN12 Gene

Paralogs for SLFN12 Gene

(5) SIMAP similar genes for SLFN12 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLFN12: view

Variants for SLFN12 Gene

Sequence variations from dbSNP and Humsavar for SLFN12 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000028843 -- 35,434,724(+) CGTGC(A/G)CGCCT downstream-variant-500B, upstream-variant-2KB
rs1000279712 -- 35,412,528(+) GACCT(A/G)GTAGT intron-variant
rs1000622909 -- 35,418,953(+) AGCTC(C/T)GCCTC intron-variant
rs1000723247 -- 35,411,214(+) AAACC(C/T)AATTA utr-variant-3-prime
rs1000987471 -- 35,410,113(+) CACAC(A/C)GTGTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLFN12 Gene

Variant ID Type Subtype PubMed ID
dgv907e212 CNV loss 25503493
esv1009166 CNV deletion 20482838
esv2715869 CNV deletion 23290073
esv2762399 CNV loss 21179565
esv3892997 CNV gain+loss 25118596
esv3892999 CNV loss 25118596
nsv1060927 CNV gain 25217958
nsv457728 CNV gain 19166990
nsv515566 CNV gain+loss 19592680
nsv574741 CNV loss 21841781
nsv574743 CNV loss 21841781
nsv574749 CNV gain+loss 21841781
dgv571e214 CNV gain 21293372
dgv570e214 CNV loss 21293372
dgv5533n54 CNV loss 21841781
dgv5532n54 CNV loss 21841781
dgv365n27 CNV loss 19166990
dgv3142n100 CNV loss 25217958

Variation tolerance for SLFN12 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLFN12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLFN12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLFN12 Gene

Disorders for SLFN12 Gene

Relevant External Links for SLFN12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLFN12

No disorders were found for SLFN12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLFN12 Gene

Publications for SLFN12 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Schlafen 12 expression modulates prostate cancer cell differentiation. (PMID: 24768141) Kovalenko PL … Basson MD (The Journal of surgical research 2014) 3 60

Products for SLFN12 Gene

Sources for SLFN12 Gene

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