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Aliases for SLFN12 Gene

Aliases for SLFN12 Gene

  • Schlafen Family Member 12 2 3 5
  • SLFN3 3

External Ids for SLFN12 Gene

Previous GeneCards Identifiers for SLFN12 Gene

  • GC17M030763
  • GC17M033738
  • GC17M029923

Summaries for SLFN12 Gene

GeneCards Summary for SLFN12 Gene

SLFN12 (Schlafen Family Member 12) is a Protein Coding gene. An important paralog of this gene is SLFN12L.

Additional gene information for SLFN12 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLFN12 Gene

Genomics for SLFN12 Gene

GeneHancer (GH) Regulatory Elements for SLFN12 Gene

Promoters and enhancers for SLFN12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I035431 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 581 +0.2 218 3.6 ATF1 ZNF213 ATF7 FOS RUNX3 KLF13 JUNB ZNF518A MAFF SMARCA4 SLFN12 ENSG00000267648 ZNF830 LIG3 ENSG00000267547 SLFN13 GC17M035431 ENSG00000267102
GH17I035372 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 18.7 +59.3 59305 2.8 HDGF SMAD1 GLI4 ZNF2 ZNF121 GLIS2 ZNF416 ZNF143 ATF7 SP3 SLFN11 GC17M035325 LOC105371933 LIG3 ZNF830 SLFN12 ENSG00000267102 ENSG00000267648 SLFN14 RFFL
GH17I035367 Enhancer 0.8 Ensembl ENCODE 10 +65.1 65053 2 HDGF DACH1 SP2 MAX ELF1 ZIC2 SP1 POLR2A PRDM10 MYC SLFN12 LOC105371933 SLFN11 GC17M035325 GC17P035345
GH17I035981 Promoter/Enhancer 1.4 EPDnew ENCODE 5.1 -548.7 -548735 1.4 ELF3 FOXA2 ARID4B THRB ZNF48 ZSCAN9 RAD21 RARA YY1 MIXL1 CCL16 ENSG00000275431 SLFN12 GC17M036109 GC17M036105
GH17I035529 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 4.9 -97.9 -97870 3.6 CTCF ZNF146 ZNF366 PRDM1 SLFN5 AP2B1 SLFN13 NLE1 SLFN12L RASL10B SLFN12 CCL5 SLFN11 RFFL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLFN12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLFN12 gene promoter:

Genomic Locations for SLFN12 Gene

Genomic Locations for SLFN12 Gene
chr17:35,409,650-35,433,283
(GRCh38/hg38)
Size:
23,634 bases
Orientation:
Minus strand
chr17:33,738,079-33,760,302
(GRCh37/hg19)

Genomic View for SLFN12 Gene

Genes around SLFN12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLFN12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLFN12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLFN12 Gene

Proteins for SLFN12 Gene

  • Protein details for SLFN12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYM2-SLN12_HUMAN
    Recommended name:
    Schlafen family member 12
    Protein Accession:
    Q8IYM2
    Secondary Accessions:
    • A8K711
    • Q9NP47

    Protein attributes for SLFN12 Gene

    Size:
    578 amino acids
    Molecular mass:
    66972 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLFN12 Gene

Post-translational modifications for SLFN12 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLFN12 Gene

Domains & Families for SLFN12 Gene

Gene Families for SLFN12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SLFN12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLFN12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYM2

UniProtKB/Swiss-Prot:

SLN12_HUMAN :
  • Belongs to the Schlafen family.
Family:
  • Belongs to the Schlafen family.
genes like me logo Genes that share domains with SLFN12: view

Function for SLFN12 Gene

Gene Ontology (GO) - Molecular Function for SLFN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SLFN12: view

Phenotypes for SLFN12 Gene

GenomeRNAi human phenotypes for SLFN12:
genes like me logo Genes that share phenotypes with SLFN12: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLFN12 Gene

Localization for SLFN12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLFN12 gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SLFN12 Gene

Pathways & Interactions for SLFN12 Gene

SuperPathways for SLFN12 Gene

No Data Available

Interacting Proteins for SLFN12 Gene

Selected Interacting proteins: Q8IYM2-SLN12_HUMAN for SLFN12 Gene via MINT IID

Gene Ontology (GO) - Biological Process for SLFN12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLFN12 Gene

Drugs & Compounds for SLFN12 Gene

No Compound Related Data Available

Transcripts for SLFN12 Gene

Unigene Clusters for SLFN12 Gene

Schlafen family member 12:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLFN12 Gene

No ASD Table

Relevant External Links for SLFN12 Gene

GeneLoc Exon Structure for
SLFN12
ECgene alternative splicing isoforms for
SLFN12

Expression for SLFN12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLFN12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLFN12 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLFN12 Gene



Protein tissue co-expression partners for SLFN12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLFN12 Gene:

SLFN12

SOURCE GeneReport for Unigene cluster for SLFN12 Gene:

Hs.663548

Evidence on tissue expression from TISSUES for SLFN12 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SLFN12: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLFN12 Gene

Orthologs for SLFN12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLFN12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLFN12 33 34
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia SLFN12L 33
  • 76.83 (n)
-- 34
  • 67 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SLFN12 33
  • 76.4 (n)
rat
(Rattus norvegicus)
Mammalia Slfn4 33
  • 66.12 (n)
mouse
(Mus musculus)
Mammalia Slfn1 34
  • 50 (a)
ManyToMany
Slfn2 34
  • 49 (a)
ManyToMany
Slfn3 34
  • 43 (a)
ManyToMany
Slfn4 34
  • 40 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 16 (a)
OneToMany
Species where no ortholog for SLFN12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLFN12 Gene

ENSEMBL:
Gene Tree for SLFN12 (if available)
TreeFam:
Gene Tree for SLFN12 (if available)

Paralogs for SLFN12 Gene

Paralogs for SLFN12 Gene

(5) SIMAP similar genes for SLFN12 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLFN12: view

Variants for SLFN12 Gene

Sequence variations from dbSNP and Humsavar for SLFN12 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000028843 -- 35,434,724(-) G/A upstream_transcript_variant
rs1000279712 -- 35,412,528(-) A/G intron_variant
rs1000622909 -- 35,418,953(-) C/T intron_variant
rs1000723247 -- 35,411,214(-) C/T 3_prime_UTR_variant
rs1000987471 -- 35,410,113(-) A/C 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLFN12 Gene

Variant ID Type Subtype PubMed ID
dgv3142n100 CNV loss 25217958
dgv365n27 CNV loss 19166990
dgv5532n54 CNV loss 21841781
dgv5533n54 CNV loss 21841781
dgv570e214 CNV loss 21293372
dgv571e214 CNV gain 21293372
dgv907e212 CNV loss 25503493
esv1009166 CNV deletion 20482838
esv2715869 CNV deletion 23290073
esv2762399 CNV loss 21179565
esv3892997 CNV gain+loss 25118596
esv3892999 CNV loss 25118596
nsv1060927 CNV gain 25217958
nsv457728 CNV gain 19166990
nsv515566 CNV gain+loss 19592680
nsv574741 CNV loss 21841781
nsv574743 CNV loss 21841781
nsv574749 CNV gain+loss 21841781

Variation tolerance for SLFN12 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLFN12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLFN12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLFN12 Gene

Disorders for SLFN12 Gene

Additional Disease Information for SLFN12

No disorders were found for SLFN12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLFN12 Gene

Publications for SLFN12 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Targeting tumor cells based on Phosphodiesterase 3A expression. (PMID: 29107068) Nazir M … Fryknäs M (Experimental cell research 2017) 3 58

Products for SLFN12 Gene

Sources for SLFN12 Gene

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