SLFN12 Gene
protein-coding GIFtS: 40
GCID: GC17M033738
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schlafen family member 12
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Aliases
for SLFN12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Schlafen Family Member 121 2 | | FLJ102601 | | SLFN32 |
Export aliases for SLFN12 gene to outside databasesPrevious GC identifers: GC17M030763 GC17M029923 |
Summaries
for SLFN12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SLFN12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLFN12 gene promoter:
AhR ISGF-3 RFX1 Lmo2 CUTL1 C/EBPalpha Arnt CREB deltaCREB HSF2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLFN12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLFN12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q12SLFN12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M033738: view genomic region
(about GC identifiers)
Start:
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33,738,079 bp from pter |
End:
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33,760,302 bp from pter |
Size:
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22,224 bases |
Orientation:
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minus strand |
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Proteins
for SLFN12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SLN12_HUMAN, Q8IYM2 (See
protein sequence)Recommended Name: Schlafen family member 12 Size: 578 amino acids; 66972 Da
Secondary accessions: A8K711 Q9NP47Explore the universe of human proteins at neXtProt for SLFN12: NX_Q8IYM2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IYM2
SLFN12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060512.3
ENSEMBL proteins: ENSP00000378063 ENSP00000302077 ENSP00000394903 ENSP00000398315 ENSP00000404175
Human Recombinant Protein Products:
SLFN12 Antibody Products:
Assay Products for SLFN12: |
Protein
Domains /
Families
for SLFN12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLFN12 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IYM2ProtoNet protein and cluster: Q8IYM2 UniProtKB/Swiss-Prot: SLN12_HUMAN, Q8IYM2Similarity: Belongs to the Schlafen family |
Function
for SLFN12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN12
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLFN12 (NM_018042) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLFN12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLFN12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLFN12 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- |
SLFN12 for ontologies About GeneDecksing
|
Pathways & Interactions
for SLFN12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLFN12
|
Drugs & Compounds
for SLFN12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLFN12
Search CenterWatch for drugs/clinical trials and news about SLFN12 / SLN12
|
Transcripts
for SLFN12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLFN12 gene: NM_018042.3 Unigene Cluster for SLFN12: Schlafen family member 12 Hs.663548 [show with all ESTs]Unigene Representative Sequence: BX6470818 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000394562(uc002hjj.4 uc010cts.3) ENST00000304905(uc002hji.4)
ENST00000452764 ENST00000460530 ENST00000479326 ENST00000447040 ENST00000445092
ENST00000428476
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN12
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLFN12 (NM_018042) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLFN12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLFN12 |
Additional cDNA sequence: AK001122.1 AK291826.1 BC035605.1 BX647081.1 6 DOTS entries: DT.203232 DT.100713816 DT.121004671 DT.99984644 DT.102829485 DT.40281717 24/43 AceView cDNA sequences (see all 43): CA434585 AA279089 AI419354 BQ227558 BE464669 BQ219120 AA279134 AU120577 AA761531 AA278409 CB215217 BI520035 AI798759 BG574411 NM_018042 BC035605 BF508339 AL708760 BF356869 BX647081 AK001122 BX472393 AI224532 BU853689
GeneLoc Exon Structure
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Expression
for SLFN12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLFN12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SLFN12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLFN12
SOURCE GeneReport for Unigene cluster: Hs.663548
SABiosciences Custom PCR Arrays for SLFN12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLFN12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLFN12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLFN12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLFN12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLFN12 |
Orthologs
for SLFN12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for SLFN12 (if available)
TreeFam Gene Tree for SLFN12 (if available) |
Paralogs
for SLFN12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLFN12 gene
- SLFN132 SLFN142 SLFN12L2 SLFN112 SLFN52
5 SIMAP similar genes for SLFN12 using alignment to 3 protein entries: SLN12_HUMAN (see all proteins):SLFN12L SLFN11 SLFN14 SLFN13 SLFN5
SLFN12 for paralogs About GeneDecksing
|
Genomic Variants
for SLFN12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLFN12 (33738079 - 33760302 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SLFN12
2 CNVs: 49846 53288 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLFN12 |
|
Disorders
/ Diseases
for SLFN12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SLFN12 for disorders About MalaCards
SLFN12 for disorders About GeneDecksing
OMIM gene information: 614955
OMIM disorders: --
Export disorders for SLFN12 gene to outside databases
|
Publications
for SLFN12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLFN12 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLFN12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Schlafen, a new family of growth regulatory genes that affect thymocyte development. (PubMed id 9846487)1 Schwarz D.A....Hedrick S.M. (1998)
|
External Searches for SLFN12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SLFN12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLFN12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLFN12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLFN12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLFN12 gene:
Search GeneIP for patents involving SLFN12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLFN12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for SLFN12 | | OriGene shRNA RFP for SLFN12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLFN12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLFN12 | | | OriGene Protein Over-expression Lysate for SLFN12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLFN12 | | OriGene 3'-UTR Clone for SLFN12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SLFN12 | | OriGene Custom Protein Services for SLFN12 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLFN12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLFN12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLFN12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLFN12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLFN12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLFN12 |
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 |  |  |  | |
| | | | Search Tocris compounds for SLFN12 |
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 | | | SLFN12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLFN12 |
|  |  |  | | | | ThermoFisher Antibodies for SLFN12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLFN12 |
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