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Aliases for SLFN12 Gene

Aliases for SLFN12 Gene

  • Schlafen Family Member 12 2 3 5
  • SLFN3 3

External Ids for SLFN12 Gene

Previous GeneCards Identifiers for SLFN12 Gene

  • GC17M030763
  • GC17M033738
  • GC17M029923

Summaries for SLFN12 Gene

GeneCards Summary for SLFN12 Gene

SLFN12 (Schlafen Family Member 12) is a Protein Coding gene. An important paralog of this gene is SLFN12L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLFN12 Gene

Genomics for SLFN12 Gene

Regulatory Elements for SLFN12 Gene

Enhancers for SLFN12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F035431 0.9 ENCODE 31 +0.2 218 3.6 TBP ATF1 INSM2 RFX5 ELK1 FOS ZNF263 SMARCC1 NFYA CEBPB SLFN12 ENSG00000267648 ENSG00000267321 ENSG00000267547 SLFN13 ENSG00000267102
GH17F035372 1 ENCODE 18.7 +59.3 59250 2.6 HDGF ATF1 GLI4 ZNF2 ZNF121 GLIS2 ZNF416 ZNF263 SP3 REST SLFN11 LIG3 SLFN12 ENSG00000270871 ZNF830 ENSG00000267102 ENSG00000267648 SLFN14 ENSG00000270894 RFFL
GH17F035367 1 Ensembl ENCODE 9.9 +65.1 65054 2.0 HDGF TAL1 SP2 USF2 MAX ZIC2 SP1 RAD51 NCOR1 POLR2A SLFN12 LOC105371933 GC17P035345
GH17F035529 1.3 FANTOM5 Ensembl ENCODE 4.9 -97.9 -97871 3.6 CTCF ZNF146 REST ZBTB40 FOSL1 ZNF316 ZNF366 ZBTB33 ZNF24 PRDM1 SLFN5 AP2B1 SLFN13 NLE1 SLFN12L RASL10B SLFN12 CCL5 SLFN11 RFFL
GH17F035428 0.2 Ensembl 27.6 +4.3 4283 0.8 SLFN12 SLFN13 ENSG00000267102
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLFN12 on UCSC Golden Path with GeneCards custom track

Promoters for SLFN12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001344775 883 2801 TBP INSM2 FEZF1 RFX5 ELK1 FOS ZNF263 SMARCC1 CEBPB JUNB

Genomic Location for SLFN12 Gene

Chromosome:
17
Start:
35,409,650 bp from pter
End:
35,433,283 bp from pter
Size:
23,634 bases
Orientation:
Minus strand

Genomic View for SLFN12 Gene

Genes around SLFN12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLFN12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLFN12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLFN12 Gene

Proteins for SLFN12 Gene

  • Protein details for SLFN12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYM2-SLN12_HUMAN
    Recommended name:
    Schlafen family member 12
    Protein Accession:
    Q8IYM2
    Secondary Accessions:
    • A8K711
    • Q9NP47

    Protein attributes for SLFN12 Gene

    Size:
    578 amino acids
    Molecular mass:
    66972 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLFN12 Gene

Post-translational modifications for SLFN12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLFN12 Gene

Domains & Families for SLFN12 Gene

Gene Families for SLFN12 Gene

Protein Domains for SLFN12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLFN12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYM2

UniProtKB/Swiss-Prot:

SLN12_HUMAN :
  • Belongs to the Schlafen family.
Family:
  • Belongs to the Schlafen family.
genes like me logo Genes that share domains with SLFN12: view

Function for SLFN12 Gene

Gene Ontology (GO) - Molecular Function for SLFN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SLFN12: view

Phenotypes for SLFN12 Gene

GenomeRNAi human phenotypes for SLFN12:
genes like me logo Genes that share phenotypes with SLFN12: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLFN12 Gene

Localization for SLFN12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLFN12 gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SLFN12 Gene

Pathways & Interactions for SLFN12 Gene

SuperPathways for SLFN12 Gene

No Data Available

Interacting Proteins for SLFN12 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000302077%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q8IYM2-SLN12_HUMAN ENSP00000302077 for SLFN12 Gene via IID STRING MINT

Gene Ontology (GO) - Biological Process for SLFN12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLFN12 Gene

Transcripts for SLFN12 Gene

Unigene Clusters for SLFN12 Gene

Schlafen family member 12:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLFN12 Gene

No ASD Table

Relevant External Links for SLFN12 Gene

GeneLoc Exon Structure for
SLFN12
ECgene alternative splicing isoforms for
SLFN12

Expression for SLFN12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLFN12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLFN12 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLFN12 Gene



Protein tissue co-expression partners for SLFN12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLFN12 Gene:

SLFN12

SOURCE GeneReport for Unigene cluster for SLFN12 Gene:

Hs.663548
genes like me logo Genes that share expression patterns with SLFN12: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLFN12 Gene

Orthologs for SLFN12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLFN12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLFN12 34 35
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia SLFN12L 34
  • 76.83 (n)
-- 35
  • 67 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SLFN12 34
  • 76.4 (n)
rat
(Rattus norvegicus)
Mammalia Slfn4 34
  • 66.12 (n)
mouse
(Mus musculus)
Mammalia Slfn1 35
  • 50 (a)
ManyToMany
Slfn2 35
  • 49 (a)
ManyToMany
Slfn3 35
  • 43 (a)
ManyToMany
Slfn4 35
  • 40 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 16 (a)
OneToMany
Species where no ortholog for SLFN12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLFN12 Gene

ENSEMBL:
Gene Tree for SLFN12 (if available)
TreeFam:
Gene Tree for SLFN12 (if available)

Paralogs for SLFN12 Gene

Paralogs for SLFN12 Gene

(5) SIMAP similar genes for SLFN12 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLFN12: view

Variants for SLFN12 Gene

Sequence variations from dbSNP and Humsavar for SLFN12 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1051582 -- 35,406,823(-) ATCTT(A/G)CCCAG utr-variant-3-prime
rs10585273 -- 35,418,686(+) TGCAC(-/CC/G)CTTTT intron-variant
rs1060884 -- 35,421,821(-) ggctc(A/G)cgcct intron-variant
rs1060885 -- 35,421,818(-) TCACG(C/T)CTGTA intron-variant
rs10671590 -- 35,418,568(+) ATATG(-/ATAC)ATACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLFN12 Gene

Variant ID Type Subtype PubMed ID
nsv515566 CNV gain+loss 19592680
nsv574741 CNV loss 21841781
nsv574743 CNV loss 21841781
nsv574749 CNV gain+loss 21841781
nsv457728 CNV gain 19166990
nsv1060927 CNV gain 25217958
esv3892999 CNV loss 25118596
esv3892997 CNV gain+loss 25118596
esv2762399 CNV loss 21179565
esv2715869 CNV deletion 23290073
esv1009166 CNV deletion 20482838
dgv907e212 CNV loss 25503493
dgv571e214 CNV gain 21293372
dgv570e214 CNV loss 21293372
dgv5533n54 CNV loss 21841781
dgv5532n54 CNV loss 21841781
dgv365n27 CNV loss 19166990
dgv3142n100 CNV loss 25217958

Variation tolerance for SLFN12 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLFN12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLFN12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLFN12 Gene

Disorders for SLFN12 Gene

Relevant External Links for SLFN12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLFN12

No disorders were found for SLFN12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLFN12 Gene

Publications for SLFN12 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Schlafen 12 expression modulates prostate cancer cell differentiation. (PMID: 24768141) Kovalenko P.L. … Basson M.D. (J. Surg. Res. 2014) 3 64
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3 64

Products for SLFN12 Gene

Sources for SLFN12 Gene

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