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Aliases for SLFN11 Gene

Aliases for SLFN11 Gene

  • Schlafen Family Member 11 2 3
  • SLFN8/9 3

External Ids for SLFN11 Gene

Summaries for SLFN11 Gene

GeneCards Summary for SLFN11 Gene

SLFN11 (Schlafen Family Member 11) is a Protein Coding gene. GO annotations related to this gene include tRNA binding. An important paralog of this gene is SLFN14.

UniProtKB/Swiss-Prot for SLFN11 Gene

  • Interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequesters tRNAs, prevents their maturation via post-transcriptional processing or accelerates their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA. May play a role in cell cycle arrest and/or induction of apoptosis in response to exogenously induced DNA damage.

Gene Wiki entry for SLFN11 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLFN11 Gene

Genomics for SLFN11 Gene

Genomic Location for SLFN11 Gene

Start:
35,350,305 bp from pter
End:
35,373,802 bp from pter
Size:
23,498 bases
Orientation:
Minus strand

Genomic View for SLFN11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLFN11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLFN11 Gene

No data available for Regulatory Elements for SLFN11 Gene

Proteins for SLFN11 Gene

  • Protein details for SLFN11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7L1-SLN11_HUMAN
    Recommended name:
    Schlafen family member 11
    Protein Accession:
    Q7Z7L1
    Secondary Accessions:
    • E1P643
    • Q8N3S8
    • Q8N762
    • Q8TEE0

    Protein attributes for SLFN11 Gene

    Size:
    901 amino acids
    Molecular mass:
    102836 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85010.1; Type=Frameshift; Positions=135; Evidence={ECO:0000305};

neXtProt entry for SLFN11 Gene

Proteomics data for SLFN11 Gene at MOPED

Post-translational modifications for SLFN11 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys97, Lys262, Lys391, Lys429, Lys743, Lys807, Lys823, and Lys890

No data available for DME Specific Peptides for SLFN11 Gene

Domains for SLFN11 Gene

Protein Domains for SLFN11 Gene

UniProtKB/Swiss-Prot:

SLN11_HUMAN
Family:
  • Belongs to the Schlafen family.:
    • Q7Z7L1
genes like me logo Genes that share domains with SLFN11: view

No data available for Gene Families for SLFN11 Gene

Function for SLFN11 Gene

Molecular function for SLFN11 Gene

UniProtKB/Swiss-Prot Function: Interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequesters tRNAs, prevents their maturation via post-transcriptional processing or accelerates their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA. May play a role in cell cycle arrest and/or induction of apoptosis in response to exogenously induced DNA damage.
UniProtKB/Swiss-Prot Induction: By type I interferons, poly-IC and poly-dAdT.

Gene Ontology (GO) - Molecular Function for SLFN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IDA 23000900
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SLFN11: view

miRNA for SLFN11 Gene

miRTarBase miRNAs that target SLFN11

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLFN11 Gene

Localization for SLFN11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLFN11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLFN11 Gene COMPARTMENTS Subcellular localization image for SLFN11 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SLFN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0016235 aggresome IDA --
genes like me logo Genes that share ontologies with SLFN11: view

Pathways for SLFN11 Gene

SuperPathways for SLFN11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLFN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051607 defense response to virus IMP 23000900
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle IMP 22927417
genes like me logo Genes that share ontologies with SLFN11: view

No data available for Pathways by source for SLFN11 Gene

Transcripts for SLFN11 Gene

Unigene Clusters for SLFN11 Gene

Schlafen family member 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLFN11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - - -
SP2: - -
SP3: - - -
SP4: - -
SP5: - - -
SP6: -
SP7:
SP8: - - - - -
SP9: - - - -
SP10:
SP11: - - - - - -

Relevant External Links for SLFN11 Gene

GeneLoc Exon Structure for
SLFN11
ECgene alternative splicing isoforms for
SLFN11

Expression for SLFN11 Gene

mRNA expression in normal human tissues for SLFN11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLFN11 Gene

SOURCE GeneReport for Unigene cluster for SLFN11 Gene Hs.745059

mRNA Expression by UniProt/SwissProt for SLFN11 Gene

Q7Z7L1-SLN11_HUMAN
Tissue specificity: Exhibits a wider expression range in ovarian and colon adenocarcinoma than in their corresponding healthy tissues.
genes like me logo Genes that share expressions with SLFN11: view

Orthologs for SLFN11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLFN11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLFN11 36
  • 98.93 (n)
  • 98.11 (a)
SLFN11 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 68 (a)
OneToMany
SLFN11 36
  • 79.9 (n)
  • 68.84 (a)
mouse
(Mus musculus)
Mammalia Slfn8 37
  • 59 (a)
ManyToMany
Slfn9 37
  • 60 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 54 (a)
OneToMany
Species with no ortholog for SLFN11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLFN11 Gene

ENSEMBL:
Gene Tree for SLFN11 (if available)
TreeFam:
Gene Tree for SLFN11 (if available)

Paralogs for SLFN11 Gene

Paralogs for SLFN11 Gene

genes like me logo Genes that share paralogs with SLFN11: view

Variants for SLFN11 Gene

Sequence variations from dbSNP and Humsavar for SLFN11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs884018 -- 35,373,143(+) TCTAG(C/G)CTTCG intron-variant
rs938298 -- 35,360,397(-) CGTCA(A/G)AATAA intron-variant
rs1047249 -- 35,351,271(-) ctaag(A/G)ttggt utr-variant-3-prime
rs1047250 -- 35,351,270(-) taagg(C/T)tggtg utr-variant-3-prime
rs1047252 -- 35,351,228(-) TCCCT(C/T)CCTCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLFN11 Gene

Variant ID Type Subtype PubMed ID
nsv457724 CNV Loss 19166990
nsv515566 CNV Gain+Loss 19592680
nsv908077 CNV Loss 21882294
dgv3142n71 CNV Gain 21882294
esv2715869 CNV Deletion 23290073
esv269947 CNV Insertion 20981092
dgv365n27 CNV Loss 19166990
nsv457728 CNV Gain 19166990

Relevant External Links for SLFN11 Gene

HapMap Linkage Disequilibrium report
SLFN11

Disorders for SLFN11 Gene

No disorders were found for SLFN11 Gene.

No data available for UniProtKB/Swiss-Prot for SLFN11 Gene

Publications for SLFN11 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. (PMID: 23000900) Li M. … David M. (Nature 2012) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents. (PMID: 22927417) Zoppoli G. … Pommier Y. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4

Products for SLFN11 Gene

Sources for SLFN11 Gene

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