SLFN11 Gene
protein-coding GIFtS: 45
GCID: GC17M033677
|
|
schlafen family member 11
| |
Aliases
for SLFN11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Schlafen Family Member 111 2 | | FLJ349221 | | SLFN8/92 |
Export aliases for SLFN11 gene to outside databasesPrevious GC identifers: GC17M030702 GC17M029862 |
Summaries
for SLFN11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SLN11_HUMAN, Q7Z7L1Function: Interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis.Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as aspecific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAsand exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: mayeither sequesters tRNAs, prevents their maturation via post-transcriptional processing or accelerates theirdeacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA
Gene Wiki entry for SLFN11
|
Genomic Views
for SLFN11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SLFN11
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLFN11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLFN11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q12SLFN11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M033677: view genomic region
(about GC identifiers)
Start:
|
33,677,324 bp from pter |
End:
|
33,700,720 bp from pter |
Size:
|
23,397 bases |
Orientation:
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minus strand |
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Proteins
for SLFN11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SLN11_HUMAN, Q7Z7L1 (See
protein sequence)Recommended Name: Schlafen family member 11 Size: 901 amino acids; 102836 Da
Sequence caution: Sequence=BAB85010.1; Type=Frameshift; Positions=135;
Secondary accessions: E1P643 Q8N3S8 Q8N762 Q8TEE0Explore the universe of human proteins at neXtProt for SLFN11: NX_Q7Z7L1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z7L1
SLFN11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001098057.1 NP_001098058.1 NP_001098059.1 NP_001098060.1 NP_689483.3
ENSEMBL proteins: ENSP00000312402 ENSP00000378067 ENSP00000465198 ENSP00000464806 ENSP00000393615 ENSP00000468095 ENSP00000397454 ENSP00000395140 ENSP00000468602 ENSP00000465777
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IDA | -- |
SLFN11 for ontologies About GeneDecksing
SLFN11 Antibody Products:
Assay Products for SLFN11: |
Protein
Domains /
Families
for SLFN11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLFN11 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z7L1ProtoNet protein and cluster: Q7Z7L1 UniProtKB/Swiss-Prot: SLN11_HUMAN, Q7Z7L1Similarity: Belongs to the Schlafen family |
Function
for SLFN11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SLN11_HUMAN, Q7Z7L1Function: Interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis.Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as aspecific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAsand exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: mayeither sequesters tRNAs, prevents their maturation via post-transcriptional processing or accelerates theirdeacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNAInduction: By type I interferons, poly-IC and poly-dAdT
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN11 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN11 (see all 5)
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Synthesis Service for SLFN11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLFN11 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLFN11 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SLFN11 for ontologies About GeneDecksing
|
Pathways & Interactions
for SLFN11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLFN11
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for SLFN11 (Q7Z7L13 ENSP000003124024) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0051607 | defense response to virus |
IMP | -- |
SLFN11 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLFN11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLFN11
Search CenterWatch for drugs/clinical trials and news about SLFN11 / SLN11
|
Transcripts
for SLFN11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLFN11 gene (5 alternative transcripts): NM_001104587.1 NM_001104588.1 NM_001104589.1 NM_001104590.1 NM_152270.3 Unigene Cluster for SLFN11: Schlafen family member 11 Hs.462829 [show with all ESTs]Unigene Representative Sequence: NM_00110458713 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000308377(uc002hjg.4) ENST00000394566(uc010ctp.3 uc010ctq.3 uc002hjh.4 uc010ctr.3)
ENST00000592108 ENST00000586099 ENST00000591682 ENST00000441608 ENST00000589811
ENST00000430814 ENST00000427966 ENST00000588579 ENST00000589562 ENST00000592122
ENST00000498396
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN11 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLFN11 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): SLFN11 (NM_001104589) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLFN11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLFN11 |
Additional cDNA sequence: AK074184.1 AK092241.1 AK310802.1 AL512731.1 AL831964.2 BC052586.1 9 DOTS entries: DT.100789662 DT.212897 DT.97843288 DT.100789656 DT.97843287 DT.100789664 DT.40292552 DT.40188852 DT.101981872 24/119 AceView cDNA sequences (see all 119): BX474510 AA354049 CA391453 BX094814 AI347123 AI521940 AA465286 AW002281 AI094915 BF724684 AI700599 CF242828 AA465168 BQ421261 AA455074 AA741467 BX504125 AA810580 AW189685 AL512731 BX474499 AW016317 BX472875 AW243036
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SLFN11 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SLFN11
|
Expression
for SLFN11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLFN11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAATTCCAGT
About this image
See SLFN11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLFN11
SOURCE GeneReport for Unigene cluster: Hs.462829
SABiosciences Custom PCR Arrays for SLFN11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLFN11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SLFN11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLFN11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLFN11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLFN11 |
Orthologs
for SLFN11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for SLFN11 (if available)
TreeFam Gene Tree for SLFN11 (if available) |
Paralogs
for SLFN11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLFN11 gene
- SLFN132 SLFN122 SLFN142 SLFN12L2 SLFN52
6 SIMAP similar genes for SLFN11 using alignment to 9 protein entries: SLN11_HUMAN (see all proteins):FLJ31952 SLFN13 SLFN12 SLFN12L SLFN5 SLFN14
SLFN11 for paralogs About GeneDecksing
|
Genomic Variants
for SLFN11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLFN11 (33677324 - 33700720 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SLFN11
2 CNVs: 49846 53288 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLFN11 |
|
Disorders
/ Diseases
for SLFN11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SLFN11 for disorders About MalaCards
SLFN11 for disorders About GeneDecksing
OMIM gene information: 614953
OMIM disorders: --
Export disorders for SLFN11 gene to outside databases
|
Publications
for SLFN11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLFN11 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with SLFN11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. (PubMed id 23000900)1, 2 Li M.... David M. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensiti zes cancer cells to DNA-damaging agents. (PubMed id 22927417)1 Zoppoli G....Pommier Y. (2012)
- NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for SLFN11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLFN11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLFN11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLFN11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLFN11 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLFN11 gene:
Search GeneIP for patents involving SLFN11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLFN11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for SLFN11 | | OriGene Custom Protein Services for SLFN11 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLFN11 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLFN11 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLFN11 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLFN11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLFN11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLFN11 |
| |
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| |  |  |  |  | | | | |
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 | | | SLFN11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLFN11 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLFN11 |
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