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Aliases for SLFN11 Gene

Aliases for SLFN11 Gene

  • Schlafen Family Member 11 2 3 5
  • SLFN8/9 3

External Ids for SLFN11 Gene

Previous GeneCards Identifiers for SLFN11 Gene

  • GC17M030702
  • GC17M033677
  • GC17M029862

Summaries for SLFN11 Gene

GeneCards Summary for SLFN11 Gene

SLFN11 (Schlafen Family Member 11) is a Protein Coding gene. GO annotations related to this gene include tRNA binding. An important paralog of this gene is SLFN13.

UniProtKB/Swiss-Prot for SLFN11 Gene

  • Interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequesters tRNAs, prevents their maturation via post-transcriptional processing or accelerates their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA. May play a role in cell cycle arrest and/or induction of apoptosis in response to exogenously induced DNA damage.

Gene Wiki entry for SLFN11 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLFN11 Gene

Genomics for SLFN11 Gene

Regulatory Elements for SLFN11 Gene

Enhancers for SLFN11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F035372 1 ENCODE 26.6 -0.2 -181 2.6 HDGF ATF1 GLI4 ZNF2 ZNF121 GLIS2 ZNF416 ZNF263 SP3 REST SLFN11 LIG3 SLFN12 ENSG00000270871 ZNF830 ENSG00000267102 ENSG00000267648 SLFN14 ENSG00000270894 RFFL
GH17F035533 1.6 FANTOM5 Ensembl ENCODE 5.3 -163.8 -163820 9.0 HDGF PKNOX1 ATF1 WRNIP1 ZNF2 YY1 ZNF143 KLF13 JUNB REST AP2B1 SLFN12L CCL5 PEX12 SLFN5 TAF5LP1 GAS2L2 SLFN11 CCL14 RFFL
GH17F035345 1.1 FANTOM5 Ensembl ENCODE 6.2 +27.6 27553 2.2 CBX2 CEBPB NR2F2 ZNF121 CBX8 CTBP2 FOXP2 EZH2 RFFL SLFN5 SLFN11 ZNF830 SLFN14 GC17P035345 LOC105371933
GH17F035341 1 Ensembl ENCODE 6.3 +31.9 31878 1.2 TBL1XR1 BMI1 EBF1 ZNF316 CBX5 ZNF143 ETV6 MAFK MTA2 TRIM22 SLFN11 GC17P035345 LOC101060119
GH17F035529 1.3 FANTOM5 Ensembl ENCODE 4.4 -157.3 -157301 3.6 CTCF ZNF146 REST ZBTB40 FOSL1 ZNF316 ZNF366 ZBTB33 ZNF24 PRDM1 SLFN5 AP2B1 SLFN13 NLE1 SLFN12L RASL10B SLFN12 CCL5 SLFN11 RFFL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLFN11 on UCSC Golden Path with GeneCards custom track

Promoters for SLFN11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001344769 353 3401 HDGF GLI4 ZNF2 ZNF121 GLIS2 ZNF416 ZNF263 SP3 REST SMARCB1

Genomic Location for SLFN11 Gene

Chromosome:
17
Start:
35,350,305 bp from pter
End:
35,373,853 bp from pter
Size:
23,549 bases
Orientation:
Minus strand

Genomic View for SLFN11 Gene

Genes around SLFN11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLFN11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLFN11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLFN11 Gene

Proteins for SLFN11 Gene

  • Protein details for SLFN11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7L1-SLN11_HUMAN
    Recommended name:
    Schlafen family member 11
    Protein Accession:
    Q7Z7L1
    Secondary Accessions:
    • E1P643
    • Q8N3S8
    • Q8N762
    • Q8TEE0

    Protein attributes for SLFN11 Gene

    Size:
    901 amino acids
    Molecular mass:
    102836 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85010.1; Type=Frameshift; Positions=135; Evidence={ECO:0000305};

neXtProt entry for SLFN11 Gene

Post-translational modifications for SLFN11 Gene

  • Ubiquitination at Lys 97, Lys 262, Lys 391, Lys 429, Lys 743, Lys 807, Lys 823, and Lys 890
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLFN11 Gene

Domains & Families for SLFN11 Gene

Gene Families for SLFN11 Gene

Protein Domains for SLFN11 Gene

Suggested Antigen Peptide Sequences for SLFN11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z7L1

UniProtKB/Swiss-Prot:

SLN11_HUMAN :
  • Belongs to the Schlafen family.
Family:
  • Belongs to the Schlafen family.
genes like me logo Genes that share domains with SLFN11: view

Function for SLFN11 Gene

Molecular function for SLFN11 Gene

UniProtKB/Swiss-Prot Function:
Interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequesters tRNAs, prevents their maturation via post-transcriptional processing or accelerates their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA. May play a role in cell cycle arrest and/or induction of apoptosis in response to exogenously induced DNA damage.
UniProtKB/Swiss-Prot Induction:
By type I interferons, poly-IC and poly-dAdT.

Gene Ontology (GO) - Molecular Function for SLFN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IDA 23000900
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SLFN11: view
genes like me logo Genes that share phenotypes with SLFN11: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLFN11 Gene

Localization for SLFN11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLFN11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLFN11 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLFN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 22927417
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0016235 aggresome IDA --
genes like me logo Genes that share ontologies with SLFN11: view

Pathways & Interactions for SLFN11 Gene

SuperPathways for SLFN11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLFN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0051607 defense response to virus IEA,IMP 23000900
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle IEA,IMP 22927417
genes like me logo Genes that share ontologies with SLFN11: view

No data available for Pathways by source and SIGNOR curated interactions for SLFN11 Gene

Transcripts for SLFN11 Gene

Unigene Clusters for SLFN11 Gene

Schlafen family member 11:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLFN11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - - -
SP2: - -
SP3: - - -
SP4: - -
SP5: - - -
SP6: -
SP7:
SP8: - - - - -
SP9: - - - -
SP10:
SP11: - - - - - -

Relevant External Links for SLFN11 Gene

GeneLoc Exon Structure for
SLFN11
ECgene alternative splicing isoforms for
SLFN11

Expression for SLFN11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLFN11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLFN11 Gene

This gene is overexpressed in Platelet (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLFN11 Gene



Protein tissue co-expression partners for SLFN11 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLFN11 Gene:

SLFN11

SOURCE GeneReport for Unigene cluster for SLFN11 Gene:

Hs.745059

mRNA Expression by UniProt/SwissProt for SLFN11 Gene:

Q7Z7L1-SLN11_HUMAN
Tissue specificity: Exhibits a wider expression range in ovarian and colon adenocarcinoma than in their corresponding healthy tissues.
genes like me logo Genes that share expression patterns with SLFN11: view

Primer Products

No data available for mRNA differential expression in normal tissues for SLFN11 Gene

Orthologs for SLFN11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLFN11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLFN11 34 35
  • 98.93 (n)
cow
(Bos Taurus)
Mammalia SLFN11 34
  • 79.9 (n)
-- 35
  • 68 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Slfn9 35
  • 60 (a)
ManyToMany
Slfn8 35
  • 59 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 54 (a)
OneToMany
Species where no ortholog for SLFN11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLFN11 Gene

ENSEMBL:
Gene Tree for SLFN11 (if available)
TreeFam:
Gene Tree for SLFN11 (if available)

Paralogs for SLFN11 Gene

Paralogs for SLFN11 Gene

genes like me logo Genes that share paralogs with SLFN11: view

Variants for SLFN11 Gene

Sequence variations from dbSNP and Humsavar for SLFN11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1047249 -- 35,351,271(-) ctaag(A/G)ttggt utr-variant-3-prime
rs1047250 -- 35,351,270(-) taagg(C/T)tggtg utr-variant-3-prime
rs1047252 -- 35,351,228(-) TCCCT(C/T)CCTCC utr-variant-3-prime
rs1047253 -- 35,351,137(-) CAAAC(C/T)CTCGC utr-variant-3-prime
rs1047268 -- 35,350,476(-) AACAA(C/T)ATTTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLFN11 Gene

Variant ID Type Subtype PubMed ID
nsv978413 CNV duplication 23825009
nsv574749 CNV gain+loss 21841781
nsv574744 CNV loss 21841781
nsv574743 CNV loss 21841781
nsv574742 CNV loss 21841781
nsv574741 CNV loss 21841781
nsv515566 CNV gain+loss 19592680
nsv457728 CNV gain 19166990
nsv457724 CNV loss 19166990
nsv1060927 CNV gain 25217958
esv3892999 CNV loss 25118596
esv3892997 CNV gain+loss 25118596
esv3582618 CNV loss 25503493
esv3346849 CNV insertion 20981092
esv3305670 CNV mobile element insertion 20981092
esv2762399 CNV loss 21179565
esv2715869 CNV deletion 23290073
dgv907e212 CNV loss 25503493
dgv571e214 CNV gain 21293372
dgv570e214 CNV loss 21293372
dgv5532n54 CNV loss 21841781
dgv365n27 CNV loss 19166990
dgv3142n100 CNV loss 25217958

Variation tolerance for SLFN11 Gene

Residual Variation Intolerance Score: 96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLFN11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLFN11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLFN11 Gene

Disorders for SLFN11 Gene

Relevant External Links for SLFN11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLFN11

No disorders were found for SLFN11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLFN11 Gene

Publications for SLFN11 Gene

  1. The schlafen family of proteins and their regulation by interferons. (PMID: 23570387) Mavrommatis E. … Platanias L.C. (J. Interferon Cytokine Res. 2013) 2 3 64
  2. Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents. (PMID: 22927417) Zoppoli G. … Pommier Y. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4 64
  3. Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. (PMID: 23000900) Li M. … David M. (Nature 2012) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SLFN11 Gene

Sources for SLFN11 Gene

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