External Ids for SLFN11 Gene
GeneCards Summary for SLFN11 Gene
SLFN11 (Schlafen Family Member 11) is a Protein Coding gene. GO annotations related to this gene include tRNA binding. An important paralog of this gene is SLFN14.
UniProtKB/Swiss-Prot for SLFN11 Gene
Interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequesters tRNAs, prevents their maturation via post-transcriptional processing or accelerates their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA. May play a role in cell cycle arrest and/or induction of apoptosis in response to exogenously induced DNA damage.