Aliases for SLF2 Gene
External Ids for SLF2 Gene
Previous HGNC Symbols for SLF2 Gene
GeneCards Summary for SLF2 Gene
SLF2 (SMC5-SMC6 Complex Localization Factor 2) is a Protein Coding gene. Diseases associated with SLF2 include Bronchiolo-Alveolar Adenocarcinoma and Interleukin-7 Receptor Alpha Deficiency. An important paralog of this gene is FAM178B.
UniProtKB/Swiss-Prot for SLF2 Gene
Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565).