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Aliases for SLF1 Gene

Aliases for SLF1 Gene

  • SMC5-SMC6 Complex Localization Factor 1 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 32 3 4
  • BRCT Domain-Containing Protein 1 3 4
  • Smc5/6 Localization Factor 1 3 4
  • BRCT Domain Containing 1 2 3
  • Ankyrin Repeat Domain 32 2 3
  • ANKRD32 3 4
  • BRCTD1 3 4
  • SMC5-SMC6 Complex Localization Factor Protein 1 3
  • BRCTx 3

External Ids for SLF1 Gene

Previous HGNC Symbols for SLF1 Gene

  • BRCTD1
  • ANKRD32

Summaries for SLF1 Gene

GeneCards Summary for SLF1 Gene

SLF1 (SMC5-SMC6 Complex Localization Factor 1) is a Protein Coding gene. An important paralog of this gene is BARD1.

UniProtKB/Swiss-Prot for SLF1 Gene

  • Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions (PubMed:25931565).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLF1 Gene

Genomics for SLF1 Gene

Regulatory Elements for SLF1 Gene

Enhancers for SLF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SLF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLF1 Gene

Chromosome:
5
Start:
94,615,858 bp from pter
End:
94,739,436 bp from pter
Size:
123,579 bases
Orientation:
Plus strand

Genomic View for SLF1 Gene

Genes around SLF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLF1 Gene

Proteins for SLF1 Gene

  • Protein details for SLF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQI6-SLF1_HUMAN
    Recommended name:
    SMC5-SMC6 complex localization factor protein 1
    Protein Accession:
    Q9BQI6
    Secondary Accessions:
    • B4DMG4
    • Q3B7K4
    • Q6NSA5
    • Q6PHW9
    • Q9Y402

    Protein attributes for SLF1 Gene

    Size:
    1058 amino acids
    Molecular mass:
    121050 Da
    Quaternary structure:
    • Interacts (via N-terminus) with SLF2; this interaction links RAD18 to the SMC5-SMC6 complex (PubMed:25931565). Interacts (via BRCT domains) with RAD18; this interaction occurs in a SLF2-independent manner (PubMed:25931565). Interacts with SMC6 (PubMed:25931565). Interacts (via BRCT domains) with RAD18 (via C-terminus and phosphorylated form); this interaction is required for efficient repair of UV-induced DNA damage (By similarity).
    SequenceCaution:
    • Sequence=AAH54885.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH54885.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH70332.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH70332.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI07572.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB66495.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLF1 Gene

Post-translational modifications for SLF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLF1 Gene

No data available for DME Specific Peptides for SLF1 Gene

Domains & Families for SLF1 Gene

Gene Families for SLF1 Gene

Protein Domains for SLF1 Gene

Suggested Antigen Peptide Sequences for SLF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BQI6

UniProtKB/Swiss-Prot:

SLF1_HUMAN :
  • BRCT domains are necessary for its targeting to ionizing radiation-induced nuclear foci.
  • Contains 3 ANK repeats.
Domain:
  • BRCT domains are necessary for its targeting to ionizing radiation-induced nuclear foci.
  • Contains 2 BRCT domains.
Similarity:
  • Contains 3 ANK repeats.
genes like me logo Genes that share domains with SLF1: view

Function for SLF1 Gene

Molecular function for SLF1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions (PubMed:25931565).

Gene Ontology (GO) - Molecular Function for SLF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25931565
GO:0031625 ubiquitin protein ligase binding IPI 25931565
GO:0032403 protein complex binding IPI 25931565
genes like me logo Genes that share ontologies with SLF1: view
genes like me logo Genes that share phenotypes with SLF1: view

Animal Models for SLF1 Gene

MGI Knock Outs for SLF1:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLF1 Gene

Localization for SLF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLF1 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Relocalizes with RAD18 to nuclear foci in response to DNA damage. Colocalizes with RAD18 in the nucleus and to centrosomes (By similarity). Associates with chromatin (PubMed:25931565). Accumulates with RAD18 and the SMC5-SMC6 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). {ECO:0000250 UniProtKB:Q8R3P9, ECO:0000269 PubMed:25931565}.

Gene Ontology (GO) - Cellular Components for SLF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome ISS --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005813 centrosome ISS --
GO:0035861 site of double-strand break IDA 25931565
genes like me logo Genes that share ontologies with SLF1: view

No data available for Subcellular locations from COMPARTMENTS for SLF1 Gene

Pathways & Interactions for SLF1 Gene

SuperPathways for SLF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IDA 25931565
GO:0031334 positive regulation of protein complex assembly IMP 25931565
GO:0034184 positive regulation of maintenance of mitotic sister chromatid cohesion IMP 25931565
GO:1990166 protein localization to site of double-strand break IDA 25931565
genes like me logo Genes that share ontologies with SLF1: view

No data available for Pathways by source and SIGNOR curated interactions for SLF1 Gene

Drugs & Compounds for SLF1 Gene

No Compound Related Data Available

Transcripts for SLF1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLF1 Gene

No ASD Table

Relevant External Links for SLF1 Gene

GeneLoc Exon Structure for
SLF1
ECgene alternative splicing isoforms for
SLF1

Expression for SLF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of SLF1 Gene:

SLF1
genes like me logo Genes that share expression patterns with SLF1: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SLF1 Gene

Orthologs for SLF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANKRD32 34
  • 90.44 (n)
  • 86.23 (a)
ANKRD32 35
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD32 34
  • 91.86 (n)
  • 88.84 (a)
ANKRD32 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd32 34
  • 85.1 (n)
  • 80.46 (a)
Slf1 16
Ankrd32 35
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANKRD32 34
  • 99.53 (n)
  • 98.68 (a)
ANKRD32 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankrd32 34
  • 85.48 (n)
  • 80.83 (a)
oppossum
(Monodelphis domestica)
Mammalia ANKRD32 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD32 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD32 34
  • 66.24 (n)
  • 52.2 (a)
ANKRD32 35
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD32 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd32 34
  • 59.24 (n)
  • 47.2 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101882450 34
  • 43.81 (n)
  • 30.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10984 35
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 13 (a)
OneToMany
Species where no ortholog for SLF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLF1 Gene

ENSEMBL:
Gene Tree for SLF1 (if available)
TreeFam:
Gene Tree for SLF1 (if available)

Paralogs for SLF1 Gene

Paralogs for SLF1 Gene

genes like me logo Genes that share paralogs with SLF1: view

Variants for SLF1 Gene

Sequence variations from dbSNP and Humsavar for SLF1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs6891545 - 94,651,827(+) GGAAG(A/C)CATAC reference, missense
rs1451733 -- 94,648,228(-) ACTAA(A/G)AAAAT intron-variant
rs1451734 -- 94,648,159(-) TTAAG(C/T)GTAAC intron-variant
rs1451735 -- 94,647,907(-) AATCT(G/T)TAAAT intron-variant
rs1549179 -- 94,679,095(-) GTGTG(A/T)ATCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLF1 Gene

Variant ID Type Subtype PubMed ID
esv2759354 CNV loss 17122850
esv7536 CNV gain 19470904
nsv435825 CNV deletion 17901297
nsv462254 CNV loss 19166990
nsv4920 CNV insertion 18451855
nsv598952 CNV loss 21841781
nsv598953 CNV loss 21841781

Variation tolerance for SLF1 Gene

Gene Damage Index Score: 2.12; 38.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLF1 Gene

Disorders for SLF1 Gene

Relevant External Links for SLF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLF1

No disorders were found for SLF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLF1 Gene

Publications for SLF1 Gene

  1. DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links. (PMID: 25931565) RAoschle M. … Mann M. (Science 2015) 2 3 4 65
  2. BRCTx is a novel, highly conserved RAD18-interacting protein. (PMID: 15632077) Adams D.J. … Bradley A. (Mol. Cell. Biol. 2005) 2 3 65
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 65
  4. KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation. (PMID: 25582440) Hong J.H. … Raught B. (Mol. Cell Proteomics 2015) 3 65
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65

Products for SLF1 Gene

Sources for SLF1 Gene

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