SLCO6A1 Gene
protein-coding GIFtS: 45
GCID: GC05M101735
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solute carrier organic anion transporter family, member...
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Aliases
for SLCO6A1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Organic Anion Transporter Family, Member 6A11 2 | | Organic Anion-Transporting Polypeptide I2 3 | | CT481 2 3 | | Solute Carrier Family 21 Member 192 3 | | OATP6A11 2 3 | | OATP-I2 3 | | GST2 3 5 | | MGC269491 | | OATPY1 2 | | Solute Carrier Organic Anion Transporter Family Member 6A12 | | Cancer/Testis Antigen 482 3 | | Testis-Specific Organic Anion Transporter2 | | Gonad-Specific Transporter2 3 | | SLC21A193 | | Organic Anion-Transporting Polypeptide 6A12 3 | | |
Export aliases for SLCO6A1 gene to outside databasesPrevious GC identifers: GC05M101783 GC05M096889 |
Summaries
for SLCO6A1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SLCO6A1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLCO6A1 gene promoter:
Max1 GR C/EBPbeta POU6F1 (c2) STAT5A AREB6 Max GR-alpha c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLCO6A1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLCO6A1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q21.1 Ensembl cytogenetic band: 5q21.1 HGNC cytogenetic band: 5q21.2SLCO6A1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M101735: view genomic region
(about GC identifiers)
Start:
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101,707,486 bp from pter |
End:
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101,834,720 bp from pter |
Size:
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127,235 bases |
Orientation:
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minus strand |
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Proteins
for SLCO6A1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SO6A1_HUMAN, Q86UG4 (See
protein sequence)Recommended Name: Solute carrier organic anion transporter family member 6A1 Size: 719 amino acids; 79232 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A6NHC1 Q6ZMY5 Q86UV2 Q8IYU5Alternative splicing: 3 isoforms: Q86UG4-1 Q86UG4-2 Q86UG4-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SLCO6A1: NX_Q86UG4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86UG4
SLCO6A1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775759.3
ENSEMBL proteins: ENSP00000421339 ENSP00000421846 ENSP00000369135 ENSP00000373671 ENSP00000421990 ENSP00000369138
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SLCO6A1 for ontologies About GeneDecksing
SLCO6A1 Antibody Products:
Assay Products for SLCO6A1: |
Protein
Domains /
Families
for SLCO6A1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLCO6A1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86UG4ProtoNet protein and cluster: Q86UG4 2 Blocks protein families: IPB004156 Organic anion transporter polypeptide (OATP) IPB011497 Protease inhibitor
UniProtKB/Swiss-Prot: SO6A1_HUMAN, Q86UG4Similarity: Belongs to the organo anion transporter (TC 2.A.60) familySimilarity: Contains 1 Kazal-like domain |
Function
for SLCO6A1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLCO6A1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLCO6A1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO6A1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005215 | transporter activity |
IEA | -- |
SLCO6A1 for ontologies About GeneDecksing
|
Pathways & Interactions
for SLCO6A1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLCO6A1
|
Drugs & Compounds
for SLCO6A1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SLCO6A1 for compounds About GeneDecksing
 Browse Tocris compounds for SLCO6A1
2 Novoseek chemical compound relationships for SLCO6A1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| thyroxine |
33 |
1 |
12923172 (1) |
| methotrexate |
26.4 |
2 |
11532100 (1), 11375950 (1) |
Search CenterWatch for drugs/clinical trials and news about SLCO6A1 / SO6A1
|
Transcripts
for SLCO6A1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLCO6A1 gene: NM_173488.3 Unigene Cluster for SLCO6A1: Solute carrier organic anion transporter family, member 6A1 Hs.388874 [show with all ESTs]Unigene Representative Sequence: NM_17348810 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000506729(uc003knn.3 uc003knp.3) ENST00000511588 ENST00000514765
ENST00000379807 ENST00000389019(uc003kno.3 uc003knq.3) ENST00000513675
ENST00000514551 ENST00000505739 ENST00000505407 ENST00000379810
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLCO6A1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLCO6A1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLCO6A1 (NM_173488) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLCO6A1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLCO6A1 |
Additional cDNA sequence: AF505657.1 AK131445.1 AY273897.1 BC034976.2 4 DOTS entries: DT.100750030 DT.40205095 DT.102821397 DT.95079143 14 AceView cDNA sequences: AL042741 AY273897 AA383531 AL040864 BI826682 BM554439 BC034976 CD557255 AF505657 AK131445 NM_173488 BI461904 BG705215 BG772379
GeneLoc Exon Structure
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Expression
for SLCO6A1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLCO6A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTCCAAAC
About this image
See SLCO6A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLCO6A1
SOURCE GeneReport for Unigene cluster: Hs.388874
UniProtKB/Swiss-Prot: SO6A1_HUMAN, Q86UG4Tissue specificity: Strongly expressed in testis. Weakly expressed in spleen, brain, fetal brain and placenta. Detectedin lung tumors
SABiosciences Custom PCR Arrays for SLCO6A1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLCO6A1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLCO6A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLCO6A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLCO6A1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO6A1 |
Orthologs
for SLCO6A1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SLCO6A1 gene from 3/14 species (see all 14) About this table
ENSEMBL Gene Tree for SLCO6A1 (if available)
TreeFam Gene Tree for SLCO6A1 (if available) |
Paralogs
for SLCO6A1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLCO6A1 gene
- SLCO2A12 SLCO4C12 SLCO1B72 ENSG000002570622 SLCO1B32 SLCO3A12 SLCO5A12 SLCO2B12
- SLCO1B12 ENSG000002570462 SLCO4A12 SLCO1A22 SLCO1C12
6 SIMAP similar genes for SLCO6A1 using alignment to 4 protein entries: SO6A1_HUMAN (see all proteins):DKFZp313M176 SLCO4C1 SLCO4A1 SLCO1B3 SLCO2A1 SLCO3A1
SLCO6A1 for paralogs About GeneDecksing
|
Genomic Variants
for SLCO6A1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLCO6A1 (101707486 - 101834720 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SLCO6A1
2 CNVs: 4469 51503 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLCO6A1 |
|
Disorders
/ Diseases
for SLCO6A1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLCO6A1 for disorders About GeneDecksing
OMIM gene information: 613365
OMIM disorders: --
2  diseases for SLCO6A1: About MalaCardslung cancer schizophrenia
Human Genome Epidemiology (HuGE) Navigator: SLCO6A1 (4 documents)
Export disorders for SLCO6A1 gene to outside databases
|
Publications
for SLCO6A1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLCO6A1 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with SLCO6A1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of novel rat and human gonad- specific organic anion transporters. (PubMed id 12677006)1, 2 Suzuki T.... Abe T. (2003)
- A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Genetic polymorphisms in Thai neonates with hyperbilirubinemia. (PubMed id 19397531)1 Prachukthum S....Hongeng S. (2009)
- Common variants conferring risk of schizophrenia. (PubMed id 19571808)1 Stefansson H....Collier D.A. (2009)
- Identification of the gonad-specific anion transporter SLCO6A1 as a cancer/testis (CT) antigen expressed in human lung cancer. (PubMed id 15546177)2 Lee S.-Y.... Old L.J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SLCO6A1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SLCO6A1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLCO6A1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLCO6A1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLCO6A1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SLCO6A1 gene:
Search GeneIP for patents involving SLCO6A1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLCO6A1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | SLCO6A1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO6A1 |
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