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Aliases for SLCO6A1 Gene

Aliases for SLCO6A1 Gene

  • Solute Carrier Organic Anion Transporter Family, Member 6A1 2 3
  • Cancer/Testis Antigen 48 2 3 4
  • Organic Anion-Transporting Polypeptide I 3 4
  • Solute Carrier Family 21 Member 19 3 4
  • Gonad-Specific Transporter 3 4
  • OATP6A1 3 4
  • OATP-I 3 4
  • CT48 3 4
  • GST 3 4
  • Organic Anion-Transporting Polypeptide 6A1 4
  • Testis-Specific Organic Anion Transporter 3
  • SLC21A19 4
  • OATPY 3

External Ids for SLCO6A1 Gene

Previous GeneCards Identifiers for SLCO6A1 Gene

  • GC05M101783
  • GC05M101735
  • GC05M096889

Summaries for SLCO6A1 Gene

GeneCards Summary for SLCO6A1 Gene

SLCO6A1 (Solute Carrier Organic Anion Transporter Family, Member 6A1) is a Protein Coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLCO1B7.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO6A1 Gene

Genomics for SLCO6A1 Gene

Regulatory Elements for SLCO6A1 Gene

Genomic Location for SLCO6A1 Gene

Chromosome:
5
Start:
102,371,782 bp from pter
End:
102,499,656 bp from pter
Size:
127,875 bases
Orientation:
Minus strand

Genomic View for SLCO6A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLCO6A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO6A1 Gene

Proteins for SLCO6A1 Gene

  • Protein details for SLCO6A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UG4-SO6A1_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 6A1
    Protein Accession:
    Q86UG4
    Secondary Accessions:
    • A6NHC1
    • Q6ZMY5
    • Q86UV2
    • Q8IYU5

    Protein attributes for SLCO6A1 Gene

    Size:
    719 amino acids
    Molecular mass:
    79232 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLCO6A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLCO6A1 Gene

Proteomics data for SLCO6A1 Gene at MOPED

Post-translational modifications for SLCO6A1 Gene

  • Glycosylation at Asn 300, Asn 497, Asn 546, and Asn 661
  • Modification sites at PhosphoSitePlus

Other Protein References for SLCO6A1 Gene

No data available for DME Specific Peptides for SLCO6A1 Gene

Domains & Families for SLCO6A1 Gene

Gene Families for SLCO6A1 Gene

Suggested Antigen Peptide Sequences for SLCO6A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q86UG4

UniProtKB/Swiss-Prot:

SO6A1_HUMAN :
  • Contains 1 Kazal-like domain.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
Domain:
  • Contains 1 Kazal-like domain.
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO6A1: view

Function for SLCO6A1 Gene

Gene Ontology (GO) - Molecular Function for SLCO6A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005515 protein binding --
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLCO6A1: view
genes like me logo Genes that share phenotypes with SLCO6A1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLCO6A1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLCO6A1 Gene

Localization for SLCO6A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO6A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLCO6A1 Gene COMPARTMENTS Subcellular localization image for SLCO6A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLCO6A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLCO6A1: view

Pathways & Interactions for SLCO6A1 Gene

SuperPathways for SLCO6A1 Gene

No Data Available

Interacting Proteins for SLCO6A1 Gene

Gene Ontology (GO) - Biological Process for SLCO6A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0043252 sodium-independent organic anion transport IBA --
GO:0098656 anion transmembrane transport IBA --
genes like me logo Genes that share ontologies with SLCO6A1: view

No data available for Pathways by source and SIGNOR curated interactions for SLCO6A1 Gene

Drugs & Compounds for SLCO6A1 Gene

(2) Drugs for SLCO6A1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Levothyroxine Approved Pharma 0
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1387
genes like me logo Genes that share compounds with SLCO6A1: view

Transcripts for SLCO6A1 Gene

mRNA/cDNA for SLCO6A1 Gene

Unigene Clusters for SLCO6A1 Gene

Solute carrier organic anion transporter family, member 6A1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLCO6A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO6A1 Gene

No ASD Table

Relevant External Links for SLCO6A1 Gene

GeneLoc Exon Structure for
SLCO6A1
ECgene alternative splicing isoforms for
SLCO6A1

Expression for SLCO6A1 Gene

mRNA expression in normal human tissues for SLCO6A1 Gene

mRNA differential expression in normal tissues according to GTEx for SLCO6A1 Gene

This gene is overexpressed in Testis (x51.7).

Protein differential expression in normal tissues from HIPED for SLCO6A1 Gene

This gene is overexpressed in Plasma (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLCO6A1 Gene



SOURCE GeneReport for Unigene cluster for SLCO6A1 Gene Hs.388874

mRNA Expression by UniProt/SwissProt for SLCO6A1 Gene

Q86UG4-SO6A1_HUMAN
Tissue specificity: Strongly expressed in testis. Weakly expressed in spleen, brain, fetal brain and placenta. Detected in lung tumors.
genes like me logo Genes that share expression patterns with SLCO6A1: view

Protein tissue co-expression partners for SLCO6A1 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLCO6A1 Gene

Orthologs for SLCO6A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLCO6A1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SLCO6A1 35
  • 75.47 (n)
  • 58.68 (a)
SLCO6A1 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slco6b1 35
  • 66.24 (n)
  • 50 (a)
Slco6b1 16
Slco6b1 36
  • 44 (a)
OneToMany
Slco6c1 36
  • 38 (a)
OneToMany
Slco6d1 36
  • 34 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SLCO6A1 35
  • 99.17 (n)
  • 98.18 (a)
SLCO6A1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slco6b1 35
  • 63.56 (n)
  • 46.38 (a)
cow
(Bos Taurus)
Mammalia SLCO6A1 36
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLCO6A1 36
  • 35 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 37 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Oatp58Db 36
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F53B1.8 36
  • 19 (a)
ManyToMany
K02G10.5 36
  • 22 (a)
ManyToMany
Y70G10A.3 36
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
Species with no ortholog for SLCO6A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLCO6A1 Gene

ENSEMBL:
Gene Tree for SLCO6A1 (if available)
TreeFam:
Gene Tree for SLCO6A1 (if available)

Paralogs for SLCO6A1 Gene

(6) SIMAP similar genes for SLCO6A1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLCO6A1: view

Variants for SLCO6A1 Gene

Sequence variations from dbSNP and Humsavar for SLCO6A1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_036622 -
VAR_036623 -
VAR_036624 -
VAR_053680 -

Structural Variations from Database of Genomic Variants (DGV) for SLCO6A1 Gene

Variant ID Type Subtype PubMed ID
nsv522882 CNV Loss 19592680
nsv462324 CNV Gain 19166990
nsv882510 CNV Loss 21882294
nsv830427 CNV Gain 17160897
nsv462325 CNV Loss 19166990
dgv6250n71 CNV Gain 21882294
nsv882512 CNV Gain 21882294
nsv882513 CNV Loss 21882294
dgv350n21 CNV Gain 19592680
nsv882517 CNV Loss 21882294
esv2730527 CNV Deletion 23290073
esv1929846 CNV Deletion 18987734
esv2730529 CNV Deletion 23290073
esv2730530 CNV Deletion 23290073
esv2730531 CNV Deletion 23290073
esv2730532 CNV Deletion 23290073
nsv830428 CNV Gain+Loss 17160897

Variation tolerance for SLCO6A1 Gene

Residual Variation Intolerance Score: 92.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.79; 79.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLCO6A1 Gene

HapMap Linkage Disequilibrium report
SLCO6A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO6A1 Gene

Disorders for SLCO6A1 Gene

Relevant External Links for SLCO6A1

Genetic Association Database (GAD)
SLCO6A1
Human Genome Epidemiology (HuGE) Navigator
SLCO6A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLCO6A1
genes like me logo Genes that share disorders with SLCO6A1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLCO6A1 Gene

Publications for SLCO6A1 Gene

  1. Cyanobacterial cyclopeptides as lead compounds to novel targeted cancer drugs. (PMID: 20411119) Sainis I. … Briasoulis E. (Mar Drugs 2010) 23 67
  2. Role of drug transporters and drug accumulation in the temporal acquisition of drug resistance. (PMID: 18980695) Hembruff S.L. … Parissenti A.M. (BMC Cancer 2008) 23 67
  3. Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene. (PMID: 16741617) Ohtsuka H. … Unno M. (J. Gastroenterol. 2006) 23 67
  4. [Drug transport in the respiratory epithelium]. (PMID: 16047280) Paul H.B. … Groneberg D.A. (Pneumologie 2005) 23 67
  5. Interactions of stevioside and steviol with renal organic anion transporters in S2 cells and mouse renal cortical slices. (PMID: 15948029) Srimaroeng C. … Chatsudthipong V. (Pharm. Res. 2005) 23 67

Products for SLCO6A1 Gene

Sources for SLCO6A1 Gene

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