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Aliases for SLCO6A1 Gene

Aliases for SLCO6A1 Gene

  • Solute Carrier Organic Anion Transporter Family Member 6A1 2 3 5
  • Cancer/Testis Antigen 48 2 3 4
  • Organic Anion-Transporting Polypeptide I 3 4
  • Solute Carrier Family 21 Member 19 3 4
  • Gonad-Specific Transporter 3 4
  • OATP6A1 3 4
  • OATP-I 3 4
  • CT48 3 4
  • GST 3 4
  • Solute Carrier Organic Anion Transporter Family, Member 6A1 2
  • Organic Anion-Transporting Polypeptide 6A1 4
  • Testis-Specific Organic Anion Transporter 3
  • Testicular Tissue Protein Li 174 3
  • SLC21A19 4
  • OATPY 3

External Ids for SLCO6A1 Gene

Previous GeneCards Identifiers for SLCO6A1 Gene

  • GC05M101783
  • GC05M101735
  • GC05M096889

Summaries for SLCO6A1 Gene

GeneCards Summary for SLCO6A1 Gene

SLCO6A1 (Solute Carrier Organic Anion Transporter Family Member 6A1) is a Protein Coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLCO4C1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO6A1 Gene

Genomics for SLCO6A1 Gene

Regulatory Elements for SLCO6A1 Gene

Enhancers for SLCO6A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F102530 0.9 Ensembl ENCODE 11.7 -32.3 -32312 2.3 HLF CEBPB CEBPG ATF2 YY1 ATF3 CEBPA PRDM10 ENSG00000249017 SLCO6A1 PAM LINC00492
GH05F102523 0.6 Ensembl 16.9 -24.0 -24045 0.6 ZNF316 MAFF TBX21 MAFK SPI1 SLCO6A1 ENSG00000249017 SLCO4C1 LINC00492
GH05F102295 1 ENCODE 5.9 +203.4 203434 2.5 ARID4B SIN3A DMAP1 ZNF48 ZNF121 GLIS2 ELK1 CBX5 ZNF143 KLF7 SLCO4C1 PAM SLCO6A1 GC05P102158
GH05F102453 0.4 Ensembl 11.5 +45.7 45656 0.4 PRDM1 ENSG00000249017 SLCO6A1 SLCO4C1 RN7SKP68
GH05F102528 0.2 ENCODE 17.1 -29.7 -29745 1.8 SLCO6A1 ENSG00000249017 PAM LINC00492
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLCO6A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLCO6A1 Gene

102,371,782 bp from pter
102,499,656 bp from pter
127,875 bases
Minus strand

Genomic View for SLCO6A1 Gene

Genes around SLCO6A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO6A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO6A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO6A1 Gene

Proteins for SLCO6A1 Gene

  • Protein details for SLCO6A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier organic anion transporter family member 6A1
    Protein Accession:
    Secondary Accessions:
    • A6NHC1
    • Q6ZMY5
    • Q86UV2
    • Q8IYU5

    Protein attributes for SLCO6A1 Gene

    719 amino acids
    Molecular mass:
    79232 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLCO6A1 Gene


neXtProt entry for SLCO6A1 Gene

Post-translational modifications for SLCO6A1 Gene

  • Glycosylation at Asn 300, Asn 497, Asn 546, and Asn 661
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLCO6A1 Gene

Domains & Families for SLCO6A1 Gene

Gene Families for SLCO6A1 Gene

Suggested Antigen Peptide Sequences for SLCO6A1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Kazal-like domain.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
  • Contains 1 Kazal-like domain.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO6A1: view

Function for SLCO6A1 Gene

Gene Ontology (GO) - Molecular Function for SLCO6A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLCO6A1: view
genes like me logo Genes that share phenotypes with SLCO6A1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLCO6A1 Gene

Localization for SLCO6A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO6A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLCO6A1 gene
Compartment Confidence
plasma membrane 5
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLCO6A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLCO6A1: view

Pathways & Interactions for SLCO6A1 Gene

SuperPathways for SLCO6A1 Gene

No Data Available

Interacting Proteins for SLCO6A1 Gene

Selected Interacting proteins: Q86UG4-SO6A1_HUMAN for SLCO6A1 Gene via IID

Gene Ontology (GO) - Biological Process for SLCO6A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0043252 sodium-independent organic anion transport IBA --
genes like me logo Genes that share ontologies with SLCO6A1: view

No data available for Pathways by source and SIGNOR curated interactions for SLCO6A1 Gene

Drugs & Compounds for SLCO6A1 Gene

(2) Drugs for SLCO6A1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SLCO6A1: view

Transcripts for SLCO6A1 Gene

mRNA/cDNA for SLCO6A1 Gene

Unigene Clusters for SLCO6A1 Gene

Solute carrier organic anion transporter family, member 6A1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO6A1 Gene

No ASD Table

Relevant External Links for SLCO6A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLCO6A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLCO6A1 Gene

mRNA differential expression in normal tissues according to GTEx for SLCO6A1 Gene

This gene is overexpressed in Testis (x51.7).

Protein differential expression in normal tissues from HIPED for SLCO6A1 Gene

This gene is overexpressed in Plasma (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLCO6A1 Gene

Protein tissue co-expression partners for SLCO6A1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLCO6A1 Gene:


SOURCE GeneReport for Unigene cluster for SLCO6A1 Gene:


mRNA Expression by UniProt/SwissProt for SLCO6A1 Gene:

Tissue specificity: Strongly expressed in testis. Weakly expressed in spleen, brain, fetal brain and placenta. Detected in lung tumors.
genes like me logo Genes that share expression patterns with SLCO6A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLCO6A1 Gene

Orthologs for SLCO6A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLCO6A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLCO6A1 34 35
  • 99.17 (n)
(Canis familiaris)
Mammalia SLCO6A1 34 35
  • 75.47 (n)
(Mus musculus)
Mammalia Slco6b1 34 16 35
  • 66.24 (n)
Slco6c1 35
  • 38 (a)
Slco6d1 35
  • 34 (a)
(Rattus norvegicus)
Mammalia Slco6b1 34
  • 63.56 (n)
(Bos Taurus)
Mammalia SLCO6A1 35
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
(Monodelphis domestica)
Mammalia SLCO6A1 35
  • 35 (a)
(Gallus gallus)
Aves -- 35
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta Oatp58Db 35
  • 16 (a)
(Caenorhabditis elegans)
Secernentea Y70G10A.3 35
  • 23 (a)
K02G10.5 35
  • 22 (a)
F53B1.8 35
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
-- 35
  • 27 (a)
-- 35
  • 27 (a)
Species where no ortholog for SLCO6A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLCO6A1 Gene

Gene Tree for SLCO6A1 (if available)
Gene Tree for SLCO6A1 (if available)

Paralogs for SLCO6A1 Gene

(6) SIMAP similar genes for SLCO6A1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLCO6A1: view

Variants for SLCO6A1 Gene

Sequence variations from dbSNP and Humsavar for SLCO6A1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10035507 -- 102,500,795(+) tttgc(A/G)tgagt upstream-variant-2KB, utr-variant-5-prime
rs10036226 -- 102,458,127(+) GGATA(C/G)CATTT intron-variant
rs10036441 -- 102,371,344(+) AATGA(A/T)CCTTG downstream-variant-500B
rs10037939 -- 102,433,177(+) tactt(C/T)gtgat intron-variant
rs10038730 -- 102,498,892(+) TCGGC(A/T)GCCCG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SLCO6A1 Gene

Variant ID Type Subtype PubMed ID
nsv830428 CNV gain+loss 17160897
nsv830427 CNV gain 17160897
nsv599189 CNV gain 21841781
nsv522882 CNV loss 19592680
nsv462325 CNV loss 19166990
nsv462324 CNV gain 19166990
nsv1030022 CNV loss 25217958
nsv1029894 CNV gain 25217958
nsv1028787 CNV gain 25217958
nsv1022583 CNV gain 25217958
nsv1020531 CNV loss 25217958
nsv1015892 CNV gain 25217958
esv3606051 CNV gain 21293372
esv3606050 CNV gain 21293372
esv3606048 CNV gain 21293372
esv3606047 CNV gain 21293372
esv3575866 CNV gain 25503493
esv2730532 CNV deletion 23290073
esv2730531 CNV deletion 23290073
esv2730530 CNV deletion 23290073
esv2730529 CNV deletion 23290073
esv2730527 CNV deletion 23290073
esv1929846 CNV deletion 18987734
dgv9977n54 CNV loss 21841781
dgv350n21 CNV gain 19592680
dgv1630e212 CNV gain 25503493

Variation tolerance for SLCO6A1 Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.79; 79.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLCO6A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO6A1 Gene

Disorders for SLCO6A1 Gene

Relevant External Links for SLCO6A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLCO6A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLCO6A1 Gene

Publications for SLCO6A1 Gene

  1. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny E.E. … Peter I. (PLoS Genet. 2012) 3 46 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Genetic polymorphisms in Thai neonates with hyperbilirubinemia. (PMID: 19397531) Prachukthum S. … Hongeng S. (Acta Paediatr. 2009) 3 46 64
  4. Common variants conferring risk of schizophrenia. (PMID: 19571808) Stefansson H. … Collier D.A. (Nature 2009) 3 46 64
  5. Identification and characterization of novel rat and human gonad- specific organic anion transporters. (PMID: 12677006) Suzuki T. … Abe T. (Mol. Endocrinol. 2003) 3 4 64

Products for SLCO6A1 Gene

Sources for SLCO6A1 Gene

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