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Aliases for SLCO5A1 Gene

Aliases for SLCO5A1 Gene

  • Solute Carrier Organic Anion Transporter Family Member 5A1 2 3 5
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 15 2 3
  • Solute Carrier Organic Anion Transporter Family, Member 5A1 2 3
  • Organic Anion Transporter Polypeptide-Related Protein 4 3 4
  • Solute Carrier Family 21 Member 15 3 4
  • SLC21A15 3 4
  • OATP-RP4 3 4
  • OATP5A1 3 4
  • OATPRP4 3 4
  • OATP-J 3
  • OATPJ 3

External Ids for SLCO5A1 Gene

Previous HGNC Symbols for SLCO5A1 Gene

  • SLC21A15

Previous GeneCards Identifiers for SLCO5A1 Gene

  • GC08M070634
  • GC08M070748
  • GC08M070584
  • GC08M066078

Summaries for SLCO5A1 Gene

Entrez Gene Summary for SLCO5A1 Gene

  • This gene encodes a 12 transmembrane domain protein that is a member of the solute carrier organic anion transporter superfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

GeneCards Summary for SLCO5A1 Gene

SLCO5A1 (Solute Carrier Organic Anion Transporter Family Member 5A1) is a Protein Coding gene. Diseases associated with SLCO5A1 include Mesomelia-Synostoses Syndrome and Mesomelia. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLCO1B7.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO5A1 Gene

Genomics for SLCO5A1 Gene

Regulatory Elements for SLCO5A1 Gene

Enhancers for SLCO5A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLCO5A1 on UCSC Golden Path with GeneCards custom track

Promoters for SLCO5A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLCO5A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLCO5A1 Gene

69,667,046 bp from pter
69,835,064 bp from pter
168,019 bases
Minus strand

Genomic View for SLCO5A1 Gene

Genes around SLCO5A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO5A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO5A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO5A1 Gene

Proteins for SLCO5A1 Gene

  • Protein details for SLCO5A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier organic anion transporter family member 5A1
    Protein Accession:
    Secondary Accessions:
    • A4QPC2
    • B2RPF7
    • B3KMU7
    • E9PKK5
    • G3V1C0

    Protein attributes for SLCO5A1 Gene

    848 amino acids
    Molecular mass:
    91864 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLCO5A1 Gene


neXtProt entry for SLCO5A1 Gene

Proteomics data for SLCO5A1 Gene at MOPED

Post-translational modifications for SLCO5A1 Gene

  • Glycosylation at Asn 228, Asn 241, Asn 469, Asn 550, Asn 590, Asn 597, and Asn 730
  • Modification sites at PhosphoSitePlus

Other Protein References for SLCO5A1 Gene

No data available for DME Specific Peptides for SLCO5A1 Gene

Domains & Families for SLCO5A1 Gene

Gene Families for SLCO5A1 Gene

Suggested Antigen Peptide Sequences for SLCO5A1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Kazal-like domain.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
  • Contains 1 Kazal-like domain.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO5A1: view

Function for SLCO5A1 Gene

genes like me logo Genes that share phenotypes with SLCO5A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLCO5A1

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLCO5A1 Gene

Localization for SLCO5A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO5A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLCO5A1 Gene COMPARTMENTS Subcellular localization image for SLCO5A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLCO5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLCO5A1: view

Pathways & Interactions for SLCO5A1 Gene

SuperPathways for SLCO5A1 Gene

No Data Available

Interacting Proteins for SLCO5A1 Gene

Gene Ontology (GO) - Biological Process for SLCO5A1 Gene


No data available for Pathways by source and SIGNOR curated interactions for SLCO5A1 Gene

Drugs & Compounds for SLCO5A1 Gene

No Compound Related Data Available

Transcripts for SLCO5A1 Gene

Unigene Clusters for SLCO5A1 Gene

Solute carrier organic anion transporter family, member 5A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO5A1 Gene

No ASD Table

Relevant External Links for SLCO5A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLCO5A1 Gene

mRNA expression in normal human tissues for SLCO5A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO5A1 Gene

This gene is overexpressed in Muscle - Skeletal (x8.7), Heart - Left Ventricle (x8.4), and Heart - Atrial Appendage (x5.5).

SOURCE GeneReport for Unigene cluster for SLCO5A1 Gene Hs.443609

genes like me logo Genes that share expression patterns with SLCO5A1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLCO5A1 Gene

Orthologs for SLCO5A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLCO5A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLCO5A1 35
  • 88.89 (n)
  • 88.97 (a)
SLCO5A1 36
  • 89 (a)
(Canis familiaris)
Mammalia SLCO5A1 35
  • 91.23 (n)
  • 92.69 (a)
SLCO5A1 36
  • 92 (a)
(Mus musculus)
Mammalia Slco5a1 35
  • 86.23 (n)
  • 89.76 (a)
Slco5a1 16
Slco5a1 36
  • 88 (a)
(Pan troglodytes)
Mammalia SLCO5A1 35
  • 99.53 (n)
  • 99.41 (a)
SLCO5A1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slco5a1 35
  • 84.24 (n)
  • 88.66 (a)
(Monodelphis domestica)
Mammalia SLCO5A1 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia SLCO5A1 36
  • 94 (a)
(Gallus gallus)
Aves SLCO5A1 35
  • 80.71 (n)
  • 85.08 (a)
SLCO5A1 36
  • 85 (a)
(Anolis carolinensis)
Reptilia SLCO5A1 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slco5a1 35
  • 74.21 (n)
  • 81.79 (a)
Str.19838 35
(Danio rerio)
Actinopterygii LOC556735 35
  • 67.3 (n)
  • 74.97 (a)
slco5a1 36
  • 69 (a)
SLCO5A1 (2 of 2) 36
  • 72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008711 35
  • 48.88 (n)
  • 40.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta Oatp30B 35
  • 50.5 (n)
  • 40.66 (a)
Oatp30B 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea F21G4.1 36
  • 24 (a)
F47E1.2 36
  • 23 (a)
F47E1.4 36
  • 24 (a)
Y32F6B.1 36
  • 21 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9649 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for SLCO5A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLCO5A1 Gene

Gene Tree for SLCO5A1 (if available)
Gene Tree for SLCO5A1 (if available)

Paralogs for SLCO5A1 Gene

(13) SIMAP similar genes for SLCO5A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLCO5A1: view

Variants for SLCO5A1 Gene

Sequence variations from dbSNP and Humsavar for SLCO5A1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_022041 -
rs2380563 -- 69,692,837(+) gacct(G/T)ccaga intron-variant
rs2380564 -- 69,692,961(+) ttcta(C/T)gtact intron-variant
rs2380566 -- 69,746,003(+) TGTCA(A/T)CCCTG intron-variant
rs2380567 -- 69,700,457(-) CTCTC(C/G/T)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO5A1 Gene

Variant ID Type Subtype PubMed ID
dgv92n68 CNV Loss 17160897
nsv6244 CNV Loss 18451855
esv22621 CNV Gain 19812545
esv33249 CNV Loss 17666407
esv5772 CNV Gain 19470904

Variation tolerance for SLCO5A1 Gene

Residual Variation Intolerance Score: 11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.48; 91.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLCO5A1 Gene

Disorders for SLCO5A1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLCO5A1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
mesomelia-synostoses syndrome
  • dominant mesomelic shortness of stature with acral synostoses, umbilical anomalies, and soft palate agenesis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLCO5A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLCO5A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLCO5A1 Gene

Publications for SLCO5A1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The superfamily of organic anion transporting polypeptides. (PMID: 12507753) Hagenbuch B. … Meier P.J. (Biochim. Biophys. Acta 2003) 2 3
  3. Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy. (PMID: 25301452) Brenner S. … Buxhofer-Ausch V. (Cancer Lett. 2015) 3
  4. Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. (PMID: 23934736) Yu B. … Boerwinkle E. (Genet. Epidemiol. 2013) 3
  5. Characterization of SLCO5A1/OATP5A1, a solute carrier transport protein with non-classical function. (PMID: 24376674) Sebastian K. … Baron J.M. (PLoS ONE 2013) 3

Products for SLCO5A1 Gene

Sources for SLCO5A1 Gene