SLCO5A1 Gene
protein-coding GIFtS: 44
GCID: GC08M070584
|
|
solute carrier organic anion transporter family, member...(Previous names: solute carrier family 21 (organic anion transporter), member...)
(Previous symbol: SLC21A15)
| |
Aliases
for SLCO5A1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Organic Anion Transporter Family, Member 5A11 2 | | Solute Carrier Family 21 (Organic Anion Transporter), Member 151 2 | | OATP5A11 2 3 | | Organic Anion Transporter Polypeptide-Related Protein 42 3 | | OATPRP41 2 3 | | Solute Carrier Family 21 Member 152 3 | | SLC21A151 2 3 | | OATP-RP42 3 | | OATP-J1 2 | | Solute Carrier Organic Anion Transporter Family Member 5A12 |
Export aliases for SLCO5A1 gene to outside databasesPrevious GC identifers: GC08M070634 GC08M070748 GC08M066078 |
Summaries
for SLCO5A1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLCO5A1:
This gene encodes a 12 transmembrane domain protein that is a member of the solute carrier organic anion transportersuperfamily. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Mar 2009)
|
Genomic Views
for SLCO5A1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLCO5A1 gene promoter:
Sox5 p53 RelA NF-kappaB N-Myc POU2F1 POU2F1a c-Myb NF-kappaB1 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLCO5A1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLCO5A1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q13.3 Ensembl cytogenetic band: 8q13.3 HGNC cytogenetic band: 8q13.1SLCO5A1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M070584: view genomic region
(about GC identifiers)
Start:
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70,584,568 bp from pter |
End:
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70,747,299 bp from pter |
Size:
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162,732 bases |
Orientation:
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minus strand |
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Proteins
for SLCO5A1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SO5A1_HUMAN, Q9H2Y9 (See
protein sequence)Recommended Name: Solute carrier organic anion transporter family member 5A1 Size: 848 amino acids; 91864 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A4QPC2 B2RPF7 B3KMU7 E9PKK5 G3V1C0Alternative splicing: 3 isoforms: Q9H2Y9-1 Q9H2Y9-2 Q9H2Y9-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SLCO5A1: NX_Q9H2Y9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H2Y9
SLCO5A1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001139480.1 NP_001139481.1 NP_112220.2
ENSEMBL proteins: ENSP00000260126 ENSP00000434422 ENSP00000432676 ENSP00000431611
Human Recombinant Protein Products for SLCO5A1:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SLCO5A1 for ontologies About GeneDecksing
SLCO5A1 Antibody Products:
Assay Products for SLCO5A1: |
Protein
Domains /
Families
for SLCO5A1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLCO5A1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H2Y9ProtoNet protein and cluster: Q9H2Y9 2 Blocks protein families: IPB004156 Organic anion transporter polypeptide (OATP) IPB011497 Protease inhibitor
UniProtKB/Swiss-Prot: SO5A1_HUMAN, Q9H2Y9Similarity: Belongs to the organo anion transporter (TC 2.A.60) familySimilarity: Contains 1 Kazal-like domain |
Function
for SLCO5A1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005215 | transporter activity |
IEA | -- |
SLCO5A1 for ontologies About GeneDecksing
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLCO5A1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO5A1 |
|
Pathways & Interactions
for SLCO5A1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLCO5A1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SLCO5A1 (ENSP000002601264) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for SLCO5A1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLCO5A1
Search CenterWatch for drugs/clinical trials and news about SLCO5A1 / SO5A1
|
Transcripts
for SLCO5A1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLCO5A1 gene (3 alternative transcripts): NM_001146008.1 NM_001146009.1 NM_030958.2 Unigene Cluster for SLCO5A1: Solute carrier organic anion transporter family, member 5A1 Hs.443609 [show with all ESTs]Unigene Representative Sequence: NM_0309588 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000260126(uc010lzb.3 uc011lfa.2 uc003xyl.3) ENST00000524945(uc003xyk.3)
ENST00000526750 ENST00000530307 ENST00000532388(uc010lzc.2) ENST00000528658
ENST00000524703 ENST00000531422
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLCO5A1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLCO5A1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Additional cDNA sequence: AF205075.1 AK022760.1 AK096879.1 AK097273.1 AK299048.1 AK307567.1 AK308488.1 BC016067.2 BC137424.1 BC139755.1 BC144618.1 4 DOTS entries: DT.75131581 DT.97817363 DT.99936253 DT.40117894 24/31 AceView cDNA sequences (see all 31): AF205075 CK904374 CR596526 NM_030958 BX116038 AK096879 BI915782 CD632982 CK904373 BM023337 CD632988 BC016067 CA449383 CD632980 AL538826 CD632984 AK022760 BE465984 AU126355 BX452286 AW204447 AI699510 CD632997 CD632990
GeneLoc Exon Structure
|
Expression
for SLCO5A1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLCO5A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SLCO5A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLCO5A1
SOURCE GeneReport for Unigene cluster: Hs.443609
SABiosciences Custom PCR Arrays for SLCO5A1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLCO5A1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO5A1 |
Orthologs
for SLCO5A1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SLCO5A1 gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SLCO5A11 |
solute carrier organic anion transporter family, member more |
80.89(n)
85.77(a) |
|
420174 XM_418287.3 XP_418287.3 |
lizard
(Anolis carolinensis) |
Reptilia |
SLCO5A16 |
-- |
85(a) |
1 ↔ 1 |
4(32003957-32066308) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.198382 |
Transcribed sequence with moderate similarity to protein more |
77.47(n) |
|
BX783610.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5567351 |
solute carrier organic anion transporter family member more |
67.17(n)
74.72(a) |
|
556735 XM_679609.4 XP_684701.3 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Oatp30B1 |
Organic anion transporting polypeptide 30B |
51.11(n)
41.61(a) |
|
34268 NM_135449.3 NP_609293.2 |
ENSEMBL Gene Tree for SLCO5A1 (if available)
TreeFam Gene Tree for SLCO5A1 (if available) |
Paralogs
for SLCO5A1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLCO5A1 gene
- SLCO2A12 SLCO4C12 SLCO1B72 ENSG000002570622 SLCO1B32 SLCO3A12 SLCO2B12 SLCO6A12
- SLCO1B12 ENSG000002570462 SLCO4A12 SLCO1A22 SLCO1C12
13 SIMAP similar genes for SLCO5A1 using alignment to 2 protein entries: SO5A1_HUMAN (see all proteins):SLCO2B1 SLCO1A2 DKFZp313M176 SLCO3A1 SLCO1B1 SLCO4C1
SLCO1B3 SLC21A8 SLCO1C1 SLCO4A1 SLCO1B7 SLCO2A1
LST3
SLCO5A1 for paralogs About GeneDecksing
|
Genomic Variants
for SLCO5A1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLCO5A1 (70584568 - 70747299 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SLCO5A1
2 CNVs: 70388 7703
1 Indel: 60711 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLCO5A1 |
|
Disorders
/ Diseases
for SLCO5A1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLCO5A1 for disorders About GeneDecksing
OMIM gene information: 613543
OMIM disorders: --
3  diseases for SLCO5A1: About MalaCardsmesomelia-synostoses syndrome mesomelia synostoses syndrome
Human Genome Epidemiology (HuGE) Navigator: SLCO5A1 (2 documents)
Export disorders for SLCO5A1 gene to outside databases
|
Publications
for SLCO5A1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLCO5A1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with SLCO5A1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The superfamily of organic anion transporting polypeptides. (PubMed id 12507753)1, 3 Hagenbuch B. and Meier P.J. (2003)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Expression and localization of the uptake transporter s OATP2B1, OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue. (PubMed id 21278488)1 Kindla J....KAPnig J. (2011)
- Mesomelia-synostoses syndrome results from deletion o f SULF1 and SLCO5A1 genes at 8q13. (PubMed id 20602915)1 Isidor B....Le Caignec C. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Common genetic variation and the control of HIV-1 in humans. (PubMed id 20041166)1 Fellay J....Goldstein D.B. (2009)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SLCO5A1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLCO5A1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLCO5A1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLCO5A1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLCO5A1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLCO5A1 gene:
Search GeneIP for patents involving SLCO5A1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLCO5A1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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