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Aliases for SLCO5A1 Gene

Aliases for SLCO5A1 Gene

  • Solute Carrier Organic Anion Transporter Family Member 5A1 2 3 5
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 15 2 3
  • Organic Anion Transporter Polypeptide-Related Protein 4 3 4
  • Solute Carrier Family 21 Member 15 3 4
  • SLC21A15 3 4
  • OATP-RP4 3 4
  • OATP5A1 3 4
  • OATPRP4 3 4
  • Solute Carrier Organic Anion Transporter Family, Member 5A1 2
  • OATP-J 3
  • OATPJ 3

External Ids for SLCO5A1 Gene

Previous HGNC Symbols for SLCO5A1 Gene

  • SLC21A15

Previous GeneCards Identifiers for SLCO5A1 Gene

  • GC08M070634
  • GC08M070748
  • GC08M070584
  • GC08M066078

Summaries for SLCO5A1 Gene

Entrez Gene Summary for SLCO5A1 Gene

  • This gene encodes a 12 transmembrane domain protein that is a member of the solute carrier organic anion transporter superfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

GeneCards Summary for SLCO5A1 Gene

SLCO5A1 (Solute Carrier Organic Anion Transporter Family Member 5A1) is a Protein Coding gene. Diseases associated with SLCO5A1 include Mesomelia-Synostoses Syndrome and Mesomelia. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLCO4A1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO5A1 Gene

Genomics for SLCO5A1 Gene

Regulatory Elements for SLCO5A1 Gene

Enhancers for SLCO5A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F069675 0.8 Ensembl ENCODE 15.3 +158.6 158647 1.6 PKNOX1 ZNF133 IKZF1 ASH2L JUNB NFE2 CREM SLCO5A1 LOC105375889 LOC101929759 GC08M069668 RN7SKP29
GH08F069763 1 Ensembl ENCODE 11.4 +70.7 70655 1.0 HDGF KLF1 PKNOX1 BMI1 ZBTB40 ZFHX2 ZNF366 EGR2 MTA2 TRIM22 LOC101929759 SLCO5A1 RN7SKP29 LOC105375889 LOC100101127 GC08P069795
GH08F069643 0.9 Ensembl ENCODE 9.7 +191.0 191005 0.8 SCRT1 CTCF ZNF654 MTA2 BHLHE40 MAX TBX21 SCRT2 IKZF1 MLLT1 RN7SKP29 LOC101929759 SLCO5A1 GC08M069668 SULF1
GH08F069978 0.8 Ensembl ENCODE 10 -144.5 -144520 1.4 SMARCA4 IKZF1 EED TEAD4 JUNB POU5F1 CREM SLCO5A1 LOC101929759 GC08M069988 SDCBPP2
GH08F069684 0.3 FANTOM5 25.7 +150.7 150748 0.2 SLCO5A1 LOC105375889 LOC101929759 GC08M069668 RN7SKP29
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLCO5A1 on UCSC Golden Path with GeneCards custom track

Promoters for SLCO5A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001393929 1064 2801 HDGF PKNOX1 WRNIP1 SIN3A FEZF1 GLI4 ZNF2 ZNF121 GLIS2 ZNF143

Genomic Location for SLCO5A1 Gene

Chromosome:
8
Start:
69,667,046 bp from pter
End:
69,835,064 bp from pter
Size:
168,019 bases
Orientation:
Minus strand

Genomic View for SLCO5A1 Gene

Genes around SLCO5A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO5A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO5A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO5A1 Gene

Proteins for SLCO5A1 Gene

  • Protein details for SLCO5A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2Y9-SO5A1_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 5A1
    Protein Accession:
    Q9H2Y9
    Secondary Accessions:
    • A4QPC2
    • B2RPF7
    • B3KMU7
    • E9PKK5
    • G3V1C0

    Protein attributes for SLCO5A1 Gene

    Size:
    848 amino acids
    Molecular mass:
    91864 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLCO5A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLCO5A1 Gene

Post-translational modifications for SLCO5A1 Gene

  • Glycosylation at Asn 228, Asn 241, Asn 469, Asn 550, Asn 590, Asn 597, and Asn 730
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLCO5A1 Gene

Domains & Families for SLCO5A1 Gene

Gene Families for SLCO5A1 Gene

Suggested Antigen Peptide Sequences for SLCO5A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H2Y9

UniProtKB/Swiss-Prot:

SO5A1_HUMAN :
  • Contains 1 Kazal-like domain.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
Domain:
  • Contains 1 Kazal-like domain.
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO5A1: view

Function for SLCO5A1 Gene

Gene Ontology (GO) - Molecular Function for SLCO5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLCO5A1: view
genes like me logo Genes that share phenotypes with SLCO5A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLCO5A1

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLCO5A1 Gene

Localization for SLCO5A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO5A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLCO5A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLCO5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLCO5A1: view

Pathways & Interactions for SLCO5A1 Gene

SuperPathways for SLCO5A1 Gene

No Data Available

Interacting Proteins for SLCO5A1 Gene

Selected Interacting proteins: Q9H2Y9-SO5A1_HUMAN for SLCO5A1 Gene via IID

Symbol External ID(s) Details
NTN1
YIPF5

Gene Ontology (GO) - Biological Process for SLCO5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0043252 sodium-independent organic anion transport IBA --
genes like me logo Genes that share ontologies with SLCO5A1: view

No data available for Pathways by source and SIGNOR curated interactions for SLCO5A1 Gene

Transcripts for SLCO5A1 Gene

Unigene Clusters for SLCO5A1 Gene

Solute carrier organic anion transporter family, member 5A1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO5A1 Gene

No ASD Table

Relevant External Links for SLCO5A1 Gene

GeneLoc Exon Structure for
SLCO5A1
ECgene alternative splicing isoforms for
SLCO5A1

Expression for SLCO5A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLCO5A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO5A1 Gene

This gene is overexpressed in Muscle - Skeletal (x8.7), Heart - Left Ventricle (x8.4), and Heart - Atrial Appendage (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of SLCO5A1 Gene:

SLCO5A1

SOURCE GeneReport for Unigene cluster for SLCO5A1 Gene:

Hs.443609
genes like me logo Genes that share expression patterns with SLCO5A1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SLCO5A1 Gene

Orthologs for SLCO5A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLCO5A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLCO5A1 34 35
  • 99.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLCO5A1 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLCO5A1 34 35
  • 91.23 (n)
cow
(Bos Taurus)
Mammalia SLCO5A1 34 35
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Slco5a1 34 16 35
  • 86.23 (n)
oppossum
(Monodelphis domestica)
Mammalia SLCO5A1 35
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slco5a1 34
  • 84.24 (n)
chicken
(Gallus gallus)
Aves SLCO5A1 34 35
  • 80.71 (n)
lizard
(Anolis carolinensis)
Reptilia SLCO5A1 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slco5a1 34
  • 74.21 (n)
Str.19838 34
zebrafish
(Danio rerio)
Actinopterygii SLCO5A1 (2 of 2) 35
  • 72 (a)
OneToMany
slco5a1 35
  • 69 (a)
OneToMany
LOC556735 34
  • 67.3 (n)
fruit fly
(Drosophila melanogaster)
Insecta Oatp30B 34 35
  • 50.5 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008711 34
  • 48.88 (n)
worm
(Caenorhabditis elegans)
Secernentea F21G4.1 35
  • 24 (a)
OneToMany
F47E1.4 35
  • 24 (a)
OneToMany
F47E1.2 35
  • 23 (a)
OneToMany
Y32F6B.1 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9649 34
Species where no ortholog for SLCO5A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLCO5A1 Gene

ENSEMBL:
Gene Tree for SLCO5A1 (if available)
TreeFam:
Gene Tree for SLCO5A1 (if available)

Paralogs for SLCO5A1 Gene

(13) SIMAP similar genes for SLCO5A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLCO5A1: view

Variants for SLCO5A1 Gene

Sequence variations from dbSNP and Humsavar for SLCO5A1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10088829 -- 69,747,148(+) ccctg(C/T)ggccc intron-variant, downstream-variant-500B
rs10088905 -- 69,736,468(+) ATCTG(C/T)AGAGA intron-variant
rs10089953 -- 69,680,398(+) ttcta(A/T)tcctg intron-variant
rs10089960 -- 69,680,413(+) aattc(A/G)cttag intron-variant
rs10089971 -- 69,740,614(+) tagca(A/C)ccaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO5A1 Gene

Variant ID Type Subtype PubMed ID
nsv6244 CNV deletion 18451855
nsv1068714 OTHER inversion 25765185
esv5772 CNV gain 19470904
esv3617554 CNV loss 21293372
esv33249 CNV loss 17666407
esv22621 CNV gain 19812545
dgv92n68 CNV loss 17160897

Variation tolerance for SLCO5A1 Gene

Residual Variation Intolerance Score: 11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.48; 91.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLCO5A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLCO5A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO5A1 Gene

Disorders for SLCO5A1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLCO5A1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
mesomelia-synostoses syndrome
  • dominant mesomelic shortness of stature with acral synostoses, umbilical anomalies, and soft palate agenesis
mesomelia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLCO5A1

Genetic Association Database (GAD)
SLCO5A1
Human Genome Epidemiology (HuGE) Navigator
SLCO5A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLCO5A1
genes like me logo Genes that share disorders with SLCO5A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLCO5A1 Gene

Publications for SLCO5A1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Common genetic variation and the control of HIV-1 in humans. (PMID: 20041166) Fellay J. … Goldstein D.B. (PLoS Genet. 2009) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The superfamily of organic anion transporting polypeptides. (PMID: 12507753) Hagenbuch B. … Meier P.J. (Biochim. Biophys. Acta 2003) 2 3 64
  5. Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy. (PMID: 25301452) Brenner S. … Buxhofer-Ausch V. (Cancer Lett. 2015) 3 64

Products for SLCO5A1 Gene

Sources for SLCO5A1 Gene

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