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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLCO5A1 Gene

protein-coding   GIFtS: 46
GCID: GC08M070584

Solute Carrier Organic Anion Transporter Family, Member...

(Previous names: solute carrier family 21 (organic anion transporter), member...)
(Previous symbol: SLC21A15)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Organic Anion Transporter Family, Member 5A11 2     OATP-RP42 3
SLC21A151 2 3     OATP5A12 3
Solute Carrier Family 21 (Organic Anion Transporter), Member 151 2     OATPRP42 3
Organic Anion Transporter Polypeptide-Related Protein 42 3     OATP-J2
Solute Carrier Family 21 Member 152 3     Solute Carrier Organic Anion Transporter Family Member 5A12

External Ids:    HGNC: 190461   Entrez Gene: 817962   Ensembl: ENSG000001375717   OMIM: 6135435   UniProtKB: Q9H2Y93   

Export aliases for SLCO5A1 gene to outside databases

Previous GC identifers: GC08M070634 GC08M070748 GC08M066078


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLCO5A1 Gene:
This gene encodes a 12 transmembrane domain protein that is a member of the solute carrier organic anion
transporter superfamily. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Mar
2009)

GeneCards Summary for SLCO5A1 Gene: 
SLCO5A1 (solute carrier organic anion transporter family, member 5A1) is a protein-coding gene. Diseases associated with SLCO5A1 include mesomelia-synostoses syndrome, and mesomelia. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLCO2A1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008183.19  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLCO5A1 gene promoter:
         Sox5   p53   RelA   NF-kappaB   N-Myc   POU2F1   POU2F1a   c-Myb   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLCO5A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLCO5A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLCO5A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13.3   Ensembl cytogenetic band:  8q13.3   HGNC cytogenetic band: 8q13.1

SLCO5A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO5A1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M070584:  view genomic region     (about GC identifiers)

Start:
70,584,568 bp from pter      End:
70,747,299 bp from pter
Size:
162,732 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SO5A1_HUMAN, Q9H2Y9 (See protein sequence)
Recommended Name: Solute carrier organic anion transporter family member 5A1  
Size: 848 amino acids; 91864 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A4QPC2 B2RPF7 B3KMU7 E9PKK5 G3V1C0
Alternative splicing: 3 isoforms:  Q9H2Y9-1   Q9H2Y9-2   Q9H2Y9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLCO5A1: NX_Q9H2Y9

Explore proteomics data for SLCO5A1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H2Y9

  • SLCO5A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLCO5A1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001139480.1  NP_001139481.1  NP_112220.2  

    ENSEMBL proteins: 
     ENSP00000260126   ENSP00000434422   ENSP00000432676   ENSP00000431611  

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    Cloud-Clone Corp. Proteins for SLCO5A1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SLCO5A1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: OATP5A1 
    SLCO family of organic anion transporting polypeptides

    4 InterPro protein domains:
     IPR002350 Kazal_dom
     IPR004156 OA_transporter
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9H2Y9

    ProtoNet protein and cluster: Q9H2Y9

    2 Blocks protein domains:
    IPB004156 Organic anion transporter polypeptide (OATP)
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: SO5A1_HUMAN, Q9H2Y9
    Similarity: Belongs to the organo anion transporter (TC 2.A.60) family
    Similarity: Contains 1 Kazal-like domain


    SLCO5A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005515protein binding ----
         
    SLCO5A1 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidSLCO5A1 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLCO5A1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLCO5A1 (ENSP000002601264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KNCNENSP000003796074STRING: ENSP00000379607
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0055085transmembrane transport ----

    SLCO5A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLCO5A1 (SO5A1)

    Search CenterWatch for drugs/clinical trials and news about SLCO5A1 / SO5A1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLCO5A1 gene (3 alternative transcripts): 
    NM_001146008.1  NM_001146009.1  NM_030958.2  

    Unigene Cluster for SLCO5A1:

    Solute carrier organic anion transporter family, member 5A1
    Hs.443609  [show with all ESTs]
    Unigene Representative Sequence: NM_030958
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260126(uc010lzb.3 uc011lfa.2 uc003xyl.3) ENST00000524945(uc003xyk.3)
    ENST00000526750 ENST00000530307 ENST00000532388(uc010lzc.2) ENST00000528658
    ENST00000524703 ENST00000531422
    miRNA
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    hsa-miR-448 hsa-let-7d hsa-miR-202 hsa-miR-128 hsa-let-7c hsa-miR-218 hsa-let-7g hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidSLCO5A1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Additional mRNA sequence: 

    AF205075.1 AK022760.1 AK096879.1 AK097273.1 AK299048.1 AK307567.1 AK308488.1 BC016067.2 
    BC137424.1 BC139755.1 BC144618.1 

    4 DOTS entries:

    DT.75131581  DT.97817363  DT.99936253  DT.40117894 

    24/31 AceView cDNA sequences (see all 31):

    CR596526 AF205075 BX116038 NM_030958 CK904374 BM023337 CD632988 CD632980 
    AW204447 BE465984 AK022760 CD632984 BX452286 CA449383 BC016067 AU126355 
    AI699510 BI915782 AL538826 AK096879 CK904373 CD632982 CD632997 CD632995 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLCO5A1 expression in normal human tissues (normalized intensities)      SLCO5A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLCO5A1 Expression
    About this image


    SLCO5A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Heart (Cardiovascular System)
             heart/pericardium   
     
     Breast (Uncategorized)
             MAMMARY GLAND   
     
     Kidney (Urinary System)
             Renal Vesicle

    See SLCO5A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLCO5A1

    SOURCE GeneReport for Unigene cluster: Hs.443609
        SABiosciences Custom PCR Arrays for SLCO5A1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO5A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLCO5A1 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slco5a11 , 5 solute carrier organic anion transporter family, member more1, 5 86.23(n)1
    89.76(a)1
      1 (3.71 cM)5
    2407261  NM_172841.21  NP_766429.21 
     128665495 
    chicken
    (Gallus gallus)
    Aves SLCO5A11 solute carrier organic anion transporter family, member more 80.89(n)
    85.77(a)
      420174  XM_418287.3  XP_418287.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLCO5A16
    Uncharacterized protein
    85(a)
    1 ↔ 1
    4(32003957-32066308)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.198382 Transcribed sequence with moderate similarity to protein more 77.47(n)    BX783610.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5567351 solute carrier organic anion transporter family member more 67.17(n)
    74.72(a)
      556735  XM_679609.4  XP_684701.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Oatp30B1 Organic anion transporting polypeptide 30B 51.11(n)
    41.61(a)
      34268  NM_135449.3  NP_609293.2 


    ENSEMBL Gene Tree for SLCO5A1 (if available)
    TreeFam Gene Tree for SLCO5A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLCO5A1 gene
    SLCO2A12  SLCO4C12  SLCO1B72  ENSG000002570622  SLCO1B32  SLCO3A12  SLCO2B12  SLCO1B12  
    SLCO6A12  SLCO1A22  SLCO1C12  ENSG000002570462  SLCO4A12  
    13 SIMAP similar genes for SLCO5A1 using alignment to 2 protein entries:     SO5A1_HUMAN (see all proteins):
    SLCO2B1    SLCO1A2    DKFZp313M176    SLCO3A1    SLCO1B1    SLCO4C1
    SLCO1B3    SLC21A8    SLCO1C1    SLCO4A1    LST3    SLCO1B7
    SLCO2A1

    SLCO5A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3470 SNPs in SLCO5A1 are shown (see all 3470)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1123248031,2
    C--70584258(+) AAAGCC/TGTCAT 3 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs119890801,2
    C,F,A,H--70584275(+) TCCCTA/GTTATG 3 -- ds500123Minor allele frequency- N:0.00EA NA NS WA CSA 1400
    rs119891091,2
    C,F,A,H--70584378(+) GATTTG/ATGATT 3 -- ds500130Minor allele frequency- A:0.22NA NS EA WA CSA 2908
    rs11385411,2
    C,F,H--70584628(-) AATGTG/ATGTGC 3 -- ut3126Minor allele frequency- A:0.39NA NS EA WA CSA 2488
    rs1854958581,2
    --70584774(+) TTAATA/GATATG 3 -- ut310--------
    rs169362791,2
    C,F,H--70584809(+) TTTGCT/GAACCG 3 -- ut31 ese333Minor allele frequency- G:0.24NA EA NS WA CSA 3405
    rs1462889681,2
    --70584852(+) GCTTTC/GAATTA 3 -- ut310--------
    rs1903257301,2
    --70584928(+) CTCAGC/TCTTGT 3 -- ut310--------
    rs601272271,2
    C--70585010(+) AAAAA-/AGAAAG 3 -- ut310--------
    rs2008763421,2
    C--70585153(+) GGTCCG/TCAGAG 5 E A mis1 ut310--------

    HapMap Linkage Disequilibrium report for SLCO5A1 (70584568 - 70747299 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SLCO5A1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6244CNV Loss18451855
    dgv92n68CNV Loss17160897
    esv33249CNV Loss17666407
    esv5772CNV Gain19470904
    esv22621CNV Gain19812545

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613543    OMIM disorders: --

    2 diseases for SLCO5A1:    About MalaCards
    mesomelia-synostoses syndrome    mesomelia


    SLCO5A1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLCO5A1
    Human Genome Epidemiology (HuGE) Navigator: SLCO5A1 (2 documents)

    Export disorders for SLCO5A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLCO5A1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SLCO5A1)
        Utopia: connect your pdf to the dynamic
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    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Common genetic variation and the control of HIV-1 in humans. (PubMed id 20041166)1, 4 Fellay J....Goldstein D.B. (2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The superfamily of organic anion transporting polypeptides. (PubMed id 12507753)1, 3 Hagenbuch B. and Meier P.J. (2003)
    5. Expression and localization of the uptake transporter s OATP2B1, OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue. (PubMed id 21278488)1 Kindla J....KAPnig J. (2011)
    6. Mesomelia-synostoses syndrome results from deletion o f SULF1 and SLCO5A1 genes at 8q13. (PubMed id 20602915)1 Isidor B....Le Caignec C. (2010)
    7. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81796 HGNC: 19046 AceView: SLCO5A1 Ensembl:ENSG00000137571 euGenes: HUgn81796
    ECgene: SLCO5A1 H-InvDB: SLCO5A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLCO5A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLCO5A1 gene:
    Search GeneIP for patents involving SLCO5A1

    GeneCards and IP:
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