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Aliases for SLCO5A1 Gene

Aliases for SLCO5A1 Gene

  • Solute Carrier Organic Anion Transporter Family, Member 5A1 2 3
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 15 2 3
  • Organic Anion Transporter Polypeptide-Related Protein 4 3 4
  • Solute Carrier Family 21 Member 15 3 4
  • SLC21A15 3 4
  • OATP-RP4 3 4
  • OATP5A1 3 4
  • OATPRP4 3 4
  • Solute Carrier Organic Anion Transporter Family Member 5A1 3
  • OATP-J 3

External Ids for SLCO5A1 Gene

Previous HGNC Symbols for SLCO5A1 Gene

  • SLC21A15

Previous GeneCards Identifiers for SLCO5A1 Gene

  • GC08M070634
  • GC08M070748
  • GC08M070584
  • GC08M066078

Summaries for SLCO5A1 Gene

Entrez Gene Summary for SLCO5A1 Gene

  • This gene encodes a 12 transmembrane domain protein that is a member of the solute carrier organic anion transporter superfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

GeneCards Summary for SLCO5A1 Gene

SLCO5A1 (Solute Carrier Organic Anion Transporter Family, Member 5A1) is a Protein Coding gene. Diseases associated with SLCO5A1 include mesomelia-synostoses syndrome and mesomelia. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLCO1B7.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO5A1 Gene

Genomics for SLCO5A1 Gene

Regulatory Elements for SLCO5A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLCO5A1 Gene

69,667,047 bp from pter
69,835,064 bp from pter
168,018 bases
Minus strand

Genomic View for SLCO5A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLCO5A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO5A1 Gene

Proteins for SLCO5A1 Gene

  • Protein details for SLCO5A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier organic anion transporter family member 5A1
    Protein Accession:
    Secondary Accessions:
    • A4QPC2
    • B2RPF7
    • B3KMU7
    • E9PKK5
    • G3V1C0

    Protein attributes for SLCO5A1 Gene

    848 amino acids
    Molecular mass:
    91864 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLCO5A1 Gene


neXtProt entry for SLCO5A1 Gene

Proteomics data for SLCO5A1 Gene at MOPED

Post-translational modifications for SLCO5A1 Gene

  • Glycosylation at Asn228, Asn241, Asn469, Asn550, Asn590, Asn597, and Asn730
  • Modification sites at PhosphoSitePlus

Other Protein References for SLCO5A1 Gene

No data available for DME Specific Peptides for SLCO5A1 Gene

Domains for SLCO5A1 Gene

Gene Families for SLCO5A1 Gene

Suggested Antigen Peptide Sequences for SLCO5A1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9H2Y9
  • Contains 1 Kazal-like domain.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO5A1: view

Function for SLCO5A1 Gene

Gene Ontology (GO) - Molecular Function for SLCO5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SLCO5A1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLCO5A1 Gene

Localization for SLCO5A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO5A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLCO5A1 Gene COMPARTMENTS Subcellular localization image for SLCO5A1 gene
Compartment Confidence
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for SLCO5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLCO5A1: view

Pathways for SLCO5A1 Gene

SuperPathways for SLCO5A1 Gene

No Data Available

Interacting Proteins for SLCO5A1 Gene

Gene Ontology (GO) - Biological Process for SLCO5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with SLCO5A1: view

No data available for Pathways by source for SLCO5A1 Gene

Transcripts for SLCO5A1 Gene

Unigene Clusters for SLCO5A1 Gene

Solute carrier organic anion transporter family, member 5A1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLCO5A1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLCO5A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO5A1 Gene

No ASD Table

Relevant External Links for SLCO5A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLCO5A1 Gene

mRNA expression in normal human tissues for SLCO5A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO5A1 Gene

This gene is overexpressed in Muscle - Skeletal (8.7), Heart - Left Ventricle (8.4), and Heart - Atrial Appendage (5.5).

SOURCE GeneReport for Unigene cluster for SLCO5A1 Gene Hs.443609

genes like me logo Genes that share expressions with SLCO5A1: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for SLCO5A1 Gene

Orthologs for SLCO5A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLCO5A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLCO5A1 35
  • 99.53 (n)
  • 99.41 (a)
SLCO5A1 36
  • 99 (a)
(Bos Taurus)
Mammalia SLCO5A1 35
  • 88.89 (n)
  • 88.97 (a)
SLCO5A1 36
  • 89 (a)
(Canis familiaris)
Mammalia SLCO5A1 35
  • 91.23 (n)
  • 92.69 (a)
SLCO5A1 36
  • 92 (a)
(Mus musculus)
Mammalia Slco5a1 35
  • 86.23 (n)
  • 89.76 (a)
Slco5a1 16
Slco5a1 36
  • 88 (a)
(Monodelphis domestica)
Mammalia SLCO5A1 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia SLCO5A1 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Slco5a1 35
  • 84.24 (n)
  • 88.66 (a)
(Gallus gallus)
Aves SLCO5A1 35
  • 80.71 (n)
  • 85.08 (a)
SLCO5A1 36
  • 85 (a)
(Anolis carolinensis)
Reptilia SLCO5A1 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slco5a1 35
  • 74.21 (n)
  • 81.79 (a)
Str.19838 35
(Danio rerio)
Actinopterygii LOC556735 35
  • 67.3 (n)
  • 74.97 (a)
slco5a1 36
  • 69 (a)
SLCO5A1 (2 of 2) 36
  • 72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008711 35
  • 48.88 (n)
  • 40.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta Oatp30B 35
  • 50.5 (n)
  • 40.66 (a)
Oatp30B 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea F21G4.1 36
  • 24 (a)
F47E1.2 36
  • 23 (a)
F47E1.4 36
  • 24 (a)
Y32F6B.1 36
  • 21 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9649 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for SLCO5A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLCO5A1 Gene

Gene Tree for SLCO5A1 (if available)
Gene Tree for SLCO5A1 (if available)

Paralogs for SLCO5A1 Gene

Selected SIMAP similar genes for SLCO5A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLCO5A1: view

Variants for SLCO5A1 Gene

Sequence variations from dbSNP and Humsavar for SLCO5A1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs937086 -- 69,733,630(-) CCACC(A/C)CCACG intron-variant
rs1138541 -- 69,672,393(-) AATGT(A/G)TGTGC utr-variant-3-prime, nc-transcript-variant
rs1343767 -- 69,738,773(-) AATTC(A/G)AGCAC intron-variant
rs1574074 -- 69,745,346(+) CATTT(C/T)TTTTA intron-variant
rs1814666 -- 69,806,988(-) AAGTG(G/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO5A1 Gene

Variant ID Type Subtype PubMed ID
dgv92n68 CNV Loss 17160897
nsv6244 CNV Loss 18451855
esv22621 CNV Gain 19812545
esv33249 CNV Loss 17666407
esv5772 CNV Gain 19470904

Relevant External Links for SLCO5A1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO5A1 Gene

Disorders for SLCO5A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SLCO5A1 Gene including...

Search for SLCO5A1 Gene in MalaCards »

Relevant External Links for SLCO5A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLCO5A1: view

No data available for UniProtKB/Swiss-Prot for SLCO5A1 Gene

Publications for SLCO5A1 Gene

  1. The superfamily of organic anion transporting polypeptides. (PMID: 12507753) Hagenbuch B. … Meier P.J. (Biochim. Biophys. Acta 2003) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Common genetic variation and the control of HIV-1 in humans. (PMID: 20041166) Fellay J. … Goldstein D.B. (PLoS Genet. 2009) 3 48
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Mesomelia-synostoses syndrome results from deletion of SULF1 and SLCO5A1 genes at 8q13. (PMID: 20602915) Isidor B. … Le Caignec C. (Am. J. Hum. Genet. 2010) 3

Products for SLCO5A1 Gene

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