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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLCO4C1 Gene

protein-coding   GIFtS: 51
GCID: GC05M101597

solute carrier organic anion transporter family, member...
 Explore 4 diseases affiliated with
SLCO4C1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLCO4C1    

Aliases
for SLCO4C1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Organic Anion Transporter Family, Member 4C11 2     Organic Anion Transporter M12 3
OATP-H1 2 3     Solute Carrier Family 21 Member 202 3
OATP4C11 2 3     OATP-M12 3
OATPX1 2 3     PRO21762
SLC21A201 2 3     Solute Carrier Organic Anion Transporter Family Member 4C12

External Ids:    HGNC: 236121   Entrez Gene: 3531892   Ensembl: ENSG000001739307   OMIM: 6090135   UniProtKB: Q6ZQN73   

Export aliases for SLCO4C1 gene to outside databases

Previous GC identifers: GC05M101647 GC05M101645 GC05M096752


Summaries
for SLCO4C1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLCO4C1:
SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile
acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et
al., 2004 (PubMed 14993604)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: SO4C1_HUMAN, Q6ZQN7
Function: Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain,
thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the
uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of
renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various
compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic
anions and compounds within or between cells. This ion-transporting process is important to maintain the strict
epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle
epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to
facilitate the acquisition of the ability to fertilize the egg




Genomic Views
for SLCO4C1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLCO4C1 gene promoter:
         SREBP-1c   NF-AT   SREBP-1b   AREB6   NF-AT4   SREBP-1a   NF-AT2   NF-AT3   Cart-1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLCO4C1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLCO4C1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLCO4C1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q21.2   Ensembl cytogenetic band:  5q21.1   HGNC cytogenetic band: 5q21

SLCO4C1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO4C1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M101597:  view genomic region     (about GC identifiers)

Start:
 101,569,690 bp from pter      End:
 101,632,253 bp from pter
Size:
 62,564 bases      Orientation:
 minus strand

Proteins
for SLCO4C1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SO4C1_HUMAN, Q6ZQN7 (See protein sequence)
Recommended Name: Solute carrier organic anion transporter family member 4C1  
Size: 724 amino acids; 78948 Da
Subcellular location: Basolateral cell membrane; Multi-pass membrane protein (By similarity). Note=Detected at the
basolateral membrane of the proximal tubule cell in the kidney (By similarity)
Miscellaneous: SLCO4C1-mediated digoxin uptake is inhibited by digoxin itself and related compounds such as ouabain,
digitoxin and digoxigenin
Secondary accessions: Q86UG5

Explore the universe of human proteins at neXtProt for SLCO4C1: NX_Q6ZQN7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6ZQN7

    • SLCO4C1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_851322.3  
    ENSEMBL proteins: 
     ENSP00000309741  
    Reactome Protein details: Q6ZQN7
    Human Recombinant Protein Products: 
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    Novus Biologicals SLCO4C1 Protein
    Novus Biologicals SLCO4C1 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLCO4C1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0016323basolateral plasma membrane IEA--


    SLCO4C1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLCO4C1

    Protein Domains /
    Families
    for SLCO4C1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLCO4C1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR004156 OA_transporter
     IPR020846 MFS_dom
     IPR011497 Kazal-type_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q6ZQN7

    ProtoNet protein and cluster: Q6ZQN7

    2 Blocks protein families:
    IPB004156 Organic anion transporter polypeptide (OATP)
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: SO4C1_HUMAN, Q6ZQN7
    Similarity: Belongs to the organo anion transporter (TC 2.A.60) family
    Similarity: Contains 1 Kazal-like domain


    Function
    for SLCO4C1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SO4C1_HUMAN, Q6ZQN7
    Function: Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain,
    thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the
    uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of
    renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various
    compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic
    anions and compounds within or between cells. This ion-transporting process is important to maintain the strict
    epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle
    epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to
    facilitate the acquisition of the ability to fertilize the egg
    Biophysicochemical properties: Kinetic parameters: KM=7.8 uM for digoxin; KM=0.38 uM for ouabain; KM=5.9 uM for
    thyroxine;

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLCO4C1
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate SLCO4C1 (see all 18):
    hsa-miR-142-3p hsa-miR-607 hsa-miR-202 hsa-miR-944 hsa-miR-340 hsa-miR-1304 hsa-miR-124 hsa-miR-2115
    SwitchGear 3'UTR luciferase reporter plasmid: SLCO4C1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLCO4C1 (see all 7)
    OriGene shRNA RFP: SLCO4C1
    OriGene siRNA: SLCO4C1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLCO4C1

    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--


    SLCO4C1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SLCO4C1:
     Increased G2M DNA content 


    Pathways & Interactions
    for SLCO4C1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transport of organic anions
    		Transport of organic anions1.00
    		Transport of vitamins, nucleosides, and related molecules0.35
    2SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for SLCO4C1
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of vitamins, nucleosides, and related molecules
    Transport of organic anions



    SLCO4C1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLCO4C1

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--
    GO:0043252sodium-independent organic anion transport TAS--


    SLCO4C1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLCO4C1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLCO4C1

    2 HMDB Compounds for SLCO4C1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    DigoxinCardoxin (see all 19)20830-75-5--

    5 DrugBank Compounds for SLCO4C1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DigitoxinDigitoksin (see all 3)71-63-6transporterinhibitor14993604
    Digoxin-- 20830-75-5transporterinhibitor14993604
    LiothyronineL-Liothyronine (see all 5)6893-02-3transportersubstrate14993604
    Liotrix-- 8065-29-0transportersubstrate14993604
    OuabainG-Strophanthin (see all 7)630-60-4transportersubstrate14993604

    Search CenterWatch for drugs/clinical trials and news about SLCO4C1 / SO4C1 

    Transcripts
    for SLCO4C1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLCO4C1 gene: 
    NM_180991.4  

    Unigene Cluster for SLCO4C1:

    Solute carrier organic anion transporter family, member 4C1
    Hs.127648  [show with all ESTs]
    Unigene Representative Sequence: NM_180991
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000310954(uc003knm.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLCO4C1
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate SLCO4C1 (see all 18):
    hsa-miR-142-3p hsa-miR-607 hsa-miR-202 hsa-miR-944 hsa-miR-340 hsa-miR-1304 hsa-miR-124 hsa-miR-2115
    SwitchGear 3'UTR luciferase reporter plasmid: SLCO4C1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLCO4C1 (see all 7)
    OriGene shRNA RFP: SLCO4C1
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLCO4C1
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLCO4C1

    Additional cDNA sequence: 

    AF119865.2 AF401643.1 AK128854.1 AY273896.2 BX647349.1 BX647577.1 BX647880.1 

    2 DOTS entries:

    DT.75101320  DT.102826059 

    24/34 AceView cDNA sequences (see all 34):

    AF401643 NM_180991 AY273896 BE552428 AI536639 AW613570 AF119865 AI247886 
    BF589967 AI824051 BX503593 BX503594 AK128854 AW271833 BX647349 BX647577 
    BX647880 AI760112 AI133558 AI174797 AA954028 BG674098 BX495927 BX496033 

    GeneLoc Exon Structure


    Expression
    for SLCO4C1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLCO4C1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAAGAACTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLCO4C1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerType1 Off Cone Bipolar CellsBipolar, Retina
    KidneyMetanephrosKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Matrigel embedded cells (Derivation of cardio...)

    See SLCO4C1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLCO4C1

    SOURCE GeneReport for Unigene cluster: Hs.127648

    UniProtKB/Swiss-Prot: SO4C1_HUMAN, Q6ZQN7
    Tissue specificity: Predominantly expressed in kidney but also weakly expressed in both fetal liver and kidney

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    In Situ
    Assay Products:     
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    Orthologs
    for SLCO4C1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLCO4C1 gene from 2/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLCO4C11 solute carrier organic anion transporter family, member more 67.74(n)
    65.9(a)    		   769132  XM_003643045.1  XP_003643093.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea F53B1.81 Protein F53B1.8 45.07(n)
    34.24(a)    		   180528  NM_075993.4  NP_508394.2 


    ENSEMBL Gene Tree for SLCO4C1 (if available)
    TreeFam Gene Tree for SLCO4C1 (if available) 

    Paralogs
    for SLCO4C1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLCO4C1 gene
    SLCO2A12  SLCO1B72  ENSG000002570622  SLCO1B32  SLCO3A12  SLCO5A12  SLCO2B12  SLCO6A12  
    SLCO1B12  ENSG000002570462  SLCO4A12  SLCO1A22  SLCO1C12  
    13 SIMAP similar genes for SLCO4C1 using alignment to 1 protein entry:     SO4C1_HUMAN:
    SLCO6A1    SLCO4A1    SLCO1B3    SLC21A8    SLCO1B1    SLCO2A1
    SLCO3A1    SLCO5A1    SLCO1A2    SLCO1C1    SLCO1B7    SLCO2B1
    LST3

    SLCO4C1 for paralogs           About GeneDecksing



    Genomic Variants
    for SLCO4C1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1188 NCBI SNPs in SLCO4C1 are shown (see all 1188)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1436738431,2
    		--101569249(+) TTGGAA/CTTTAC 1 -- ds50010--------
    rs14691041,2
    		C,F,O,A,H,--101569545(-) TTTCTT/CGTATC 1 -- ds500133Minor allele frequency- C:0.48NS EA NA WA CSA 2930
    rs1471863091,2
    		--101569561(+) GGATTA/GAATTA 1 -- ds50010--------
    rs1813272211,2
    		--101569684(+) AAACAC/TGACAA 1 -- ds50010--------
    rs1396501621,2
    		--101569692(+) CAATTC/TTGTAT 1 -- ut310--------
    rs561845371,2
    		C--101569748(+) TTTACA/GATAAA 1 -- ut310--------
    rs1493144591,2
    		--101569957(+) AACAAC/TCATAA 1 -- ut310--------
    rs1114677651,2
    		--101569974(+) AAAAAC/TGCACT 1 -- ut312Minor allele frequency- T:0.04CSA WA 120
    rs1850714111,2
    		--101570124(+) TATATA/GTAAAA 1 -- ut310--------
    rs1118646111,2
    		C,--101570135(+) GCTCCT/AGACTC 1 -- ut311Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for SLCO4C1 (101569690 - 101632253 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLCO4C1: --

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    Disorders / Diseases
    for SLCO4C1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLCO4C1 for disorders           About GeneDecksing

    OMIM gene information: 609013    OMIM disorders: --

    4 diseases for SLCO4C1:    About MalaCards
    essential hypertension    thyroiditis    epididymitis    hypertension

    Human Genome Epidemiology (HuGE) Navigator: SLCO4C1 (7 documents)

    Export disorders for SLCO4C1 gene to outside databases

    Publications
    for SLCO4C1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLCO4C1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SLCO4C1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. (PubMed id 14993604)1, 2, 7, 9 Mikkaichi T.... Abe T. (2004)
    2. Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein. (PubMed id 17314201)2, 9 Chu X.Y....Evers R. (2007)
    3. Genetic variation in solute carrier genes is associat ed with preeclampsia. (PubMed id 20691413)1 Morrison A.C....Puschett J.B. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    5. Transport of estrone 3-sulfate mediated by organic an ion transporter OATP4C1: estrone 3-sulfate binds to the different recognition s ite for digoxin in OATP4C1. (PubMed id 20610891)1 Yamaguchi H....Mano N. (2010)
    6. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    7. SLCO4C1 transporter eliminates uremic toxins and atte nuates hypertension and renal inflammation. (PubMed id 19875811)1 Toyohara T....Abe T. (2009)
    8. Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain. (PubMed id 19197249)1 Tripodi G....Manunta P. (2009)
    9. Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenc lature and molecular/functional properties. (PubMed id 14579113)1 Hagenbuch B. and Meier P.J. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    External Searches for SLCO4C1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing SLCO4C1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 353189 HGNC: 23612 AceView: SLCO4C1 Ensembl:ENSG00000173930 euGenes: HUgn353189
    ECgene: SLCO4C1 H-InvDB: SLCO4C1

    Other Databases showing SLCO4C1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLCO4C1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLCO4C1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLCO4C1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLCO4C1 gene:
    Search GeneIP for patents involving SLCO4C1

    GeneCards and IP:
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