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SLCO4C1 Gene

protein-coding   GIFtS: 55
GCID: GC05M101597

Solute Carrier Organic Anion Transporter Family, Member...

  See SLCO4C1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Organic Anion Transporter Family, Member 4C11 2     OATP-M12 3
OATP4C12 3 5     OATPX2 3
Organic Anion Transporter M12 3     SLC21A202 3
Solute Carrier Family 21 Member 202 3     PRO21762
OATP-H2 3     Solute Carrier Organic Anion Transporter Family Member 4C12

External Ids:    HGNC: 236121   Entrez Gene: 3531892   Ensembl: ENSG000001739307   OMIM: 6090135   UniProtKB: Q6ZQN73   

Export aliases for SLCO4C1 gene to outside databases

Previous GC identifers: GC05M101647 GC05M101645 GC05M096752


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLCO4C1 Gene:
SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of
bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues
(Mikkaichi et al., 2004 (PubMed 14993604)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLCO4C1 Gene:
SLCO4C1 (solute carrier organic anion transporter family, member 4C1) is a protein-coding gene. Diseases associated with SLCO4C1 include eastern equine encephalitis. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLCO2A1.

UniProtKB/Swiss-Prot: SO4C1_HUMAN, Q6ZQN7
Function: Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain,
thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in
the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into
and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and
various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement
of organic anions and compounds within or between cells. This ion-transporting process is important to maintain
the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since
seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface
proteins to facilitate the acquisition of the ability to fertilize the egg




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLCO4C1 gene promoter:
         SREBP-1c   NF-AT   SREBP-1b   AREB6   NF-AT4   SREBP-1a   NF-AT2   NF-AT3   Cart-1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLCO4C1 promoter sequence
   Search Chromatin IP Primers for SLCO4C1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLCO4C1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q21.2   Ensembl cytogenetic band:  5q21.1   HGNC cytogenetic band: 5q21

SLCO4C1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO4C1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M101597:  view genomic region     (about GC identifiers)

Start:
101,569,690 bp from pter      End:
101,632,253 bp from pter
Size:
62,564 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SO4C1_HUMAN, Q6ZQN7 (See protein sequence)
Recommended Name: Solute carrier organic anion transporter family member 4C1  
Size: 724 amino acids; 78948 Da
Miscellaneous: SLCO4C1-mediated digoxin uptake is inhibited by digoxin itself and related compounds such as
ouabain, digitoxin and digoxigenin
Secondary accessions: Q86UG5

Explore the universe of human proteins at neXtProt for SLCO4C1: NX_Q6ZQN7

Explore proteomics data for SLCO4C1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr557
  • Modification sites at PhosphoSitePlus

  • See SLCO4C1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_851322.3  
    ENSEMBL proteins: 
     ENSP00000309741  
    Reactome Protein details: Q6ZQN7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: OATP4C1
    SLCO family of organic anion transporting polypeptides

    4 InterPro protein domains:
     IPR002350 Kazal_dom
     IPR004156 OA_transporter
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q6ZQN7

    ProtoNet protein and cluster: Q6ZQN7

    2 Blocks protein domains:
    IPB004156 Organic anion transporter polypeptide (OATP)
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: SO4C1_HUMAN, Q6ZQN7
    Similarity: Belongs to the organo anion transporter (TC 2.A.60) family
    Similarity: Contains 1 Kazal-like domain


    Find genes that share domains with SLCO4C1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SO4C1_HUMAN, Q6ZQN7
    Function: Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain,
    thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in
    the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into
    and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and
    various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement
    of organic anions and compounds within or between cells. This ion-transporting process is important to maintain
    the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since
    seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface
    proteins to facilitate the acquisition of the ability to fertilize the egg
    Biophysicochemical properties: Kinetic parameters: KM=7.8 uM for digoxin; KM=0.38 uM for ouabain; KM=5.9 uM for
    thyroxine;

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SLCO4C1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLCO4C1:
     Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLCO4C1
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    miRTarBase miRNAs that target SLCO4C1:
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    Selected qRT-PCR Assays for microRNAs that regulate SLCO4C1 (see all 18):
    hsa-miR-142-3p hsa-miR-607 hsa-miR-202 hsa-miR-944 hsa-miR-340 hsa-miR-1304 hsa-miR-124 hsa-miR-2115
    SwitchGear 3'UTR luciferase reporter plasmidSLCO4C1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SO4C1_HUMAN, Q6ZQN7: Basolateral cell membrane; Multi-pass membrane protein (By similarity). Note=Detected at the
    basolateral membrane of the proximal tubule cell in the kidney (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0016323basolateral plasma membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with SLCO4C1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLCO4C1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transmembrane transport of small molecules0.47
    2Transport of vitamins, nucleosides, and related molecules
    Transport of organic anions0.00
    Transport of vitamins, nucleosides, and related molecules


    Find genes that share SuperPaths with SLCO4C1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLCO4C1
        Transport of organic anions


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLCO4C1
    Interactions:

        Search GeneGlobe Interaction Network for SLCO4C1

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--
    GO:0043252sodium-independent organic anion transport TAS--

    Find genes that share ontologies with SLCO4C1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for SLCO4C1 (SO4C1)

    2 HMDB Compounds for SLCO4C1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    DigoxinCardoxin (see all 19)20830-75-5--

    9 DrugBank Compounds for SLCO4C1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Dextrothyroxine-- 51-49-0transporter--14993604
    DigitoxinDigitoksin (see all 3)71-63-6transporterinhibitor14993604
    Digoxin-- 20830-75-5transporterinhibitor14993604
    Levothyroxine(-)-Thyroxine (see all 13)51-48-9transporter--14993604
    LiothyronineL-Liothyronine (see all 5)6893-02-3transportersubstrate14993604
    Liotrix-- 8065-29-0transportersubstrate14993604
    MethotrexateAmethopterin (see all 12)59-05-2transporter--14993604
    OuabainG-Strophanthin (see all 7)630-60-4transportersubstrate14993604
    SaxagliptinBMS-477118 (see all 2)361442-04-8transportersubstrate22686547

    1 IUPHAR Ligand for SLCO4C1 (OATP4C1)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]digoxin
    NoneNone--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLCO4C1 gene: 
    NM_180991.4  

    Unigene Cluster for SLCO4C1:

    Solute carrier organic anion transporter family, member 4C1
    Hs.127648  [show with all ESTs]
    Unigene Representative Sequence: NM_180991
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000310954(uc003knm.3)
    miRNA
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    hsa-miR-142-3p hsa-miR-607 hsa-miR-202 hsa-miR-944 hsa-miR-340 hsa-miR-1304 hsa-miR-124 hsa-miR-2115
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    Additional mRNA sequence: 

    AF119865.2 AF401643.1 AK128854.1 AY273896.2 BX647349.1 BX647577.1 BX647880.1 

    2 DOTS entries:

    DT.75101320  DT.102826059 

    Selected AceView cDNA sequences (see all 34):

    AI536639 AW613570 NM_180991 AI824051 BF589967 BE552428 AF119865 AY273896 
    BX503593 AF401643 AI247886 BX647880 BX503594 AA954028 AI133558 AI760112 
    AW271833 AK128854 BX647349 AI174797 BX647577 BX495927 AW243186 BG428310 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLCO4C1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAGAACTG
    SLCO4C1 Expression
    About this image


    SLCO4C1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Tip Cells Ureteric Bud
             Metanephros
     
     Neurons
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
    SLCO4C1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLCO4C1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.127648

    UniProtKB/Swiss-Prot: SO4C1_HUMAN, Q6ZQN7
    Tissue specificity: Predominantly expressed in kidney but also weakly expressed in both fetal liver and kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLCO4C1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slco4c11 , 5 solute carrier organic anion transporter family, member more1, 5 81.92(n)1
    80.75(a)1
      1 (47.76 cM)5
    2273941  NM_172658.31  NP_766246.11 
     968187845 
    chicken
    (Gallus gallus)
    Aves SLCO4C11 solute carrier organic anion transporter family, member more 67.69(n)
    65.9(a)
      769132  XM_003643045.2  XP_003643093.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    43(a)
    1 → many
    GL343193.1(1248811-1292627)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slco4c11 solute carrier organic anion transporter family, member more 64.07(n)
    59.08(a)
      100485817  XM_002933444.2  XP_002933490.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Oatp33Eb6
    Organic anion transporting polypeptide 33Eb
    16(a)
    many ↔ many
    2L(12448484-12452047)
    worm
    (Caenorhabditis elegans)
    Secernentea F53B1.81 F53B1.8 44.09(n)
    33.03(a)
      180528  NM_075993.5  NP_508394.2 


    ENSEMBL Gene Tree for SLCO4C1 (if available)
    TreeFam Gene Tree for SLCO4C1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLCO4C1 gene
    SLCO2A12  SLCO1B72  ENSG000002570622  SLCO1B32  SLCO3A12  SLCO2B12  SLCO5A12  SLCO1B12  
    SLCO6A12  SLCO1A22  ENSG000002570462  SLCO4A12  SLCO1C12  
    13 SIMAP similar genes for SLCO4C1 using alignment to 1 protein entry:     SO4C1_HUMAN:
    SLCO6A1    SLCO4A1    SLC21A8    SLCO1B3    LST3    SLCO1B1
    SLCO2A1    SLCO3A1    SLCO5A1    SLCO1A2    SLCO1C1    SLCO1B7
    SLCO2B1

    Find genes that share paralogs with SLCO4C1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLCO4C1 (see all 1361)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1436738431,2
    C--101569249(+) TTGGAA/CTTTAC 1 -- ds50010--------
    rs14691041,2
    C,F,O,A,H--101569545(-) TTTCTT/CGTATC 1 -- ds500133Minor allele frequency- C:0.48NS EA NA WA CSA 2930
    rs1471863091,2
    --101569561(+) GGATTA/GAATTA 1 -- ds50010--------
    rs1813272211,2
    --101569684(+) AAACAC/TGACAA 1 -- ds50010--------
    rs1396501621,2
    --101569692(+) CAATTC/TTGTAT 1 -- ut310--------
    rs561845371,2
    C--101569748(+) TTTACA/GATAAA 1 -- ut310--------
    rs1493144591,2
    --101569957(+) AACAAC/TCATAA 1 -- ut310--------
    rs1114677651,2
    C,F--101569974(+) AAAAAC/TGCACT 1 -- ut312Minor allele frequency- T:0.04CSA WA 120
    rs1850714111,2
    --101570124(+) TATATA/GTAAAA 1 -- ut310--------
    rs1118646111,2
    C,F--101570135(+) GCTCCT/AGACTC 1 -- ut311Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for SLCO4C1 (101569690 - 101632253 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SLCO4C1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678701CNV Deletion23128226
    nsv507279CNV Insertion20534489
    esv268733CNV Insertion20981092
    nsv522882CNV Loss19592680
    nsv882505CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLCO4C1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLCO4C1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609013    OMIM disorders: --

    1 disease for SLCO4C1:    
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    eastern equine encephalitis

    1 disease from the University of Copenhagen DISEASES database for SLCO4C1:
    Eastern equine encephalitis

    Find genes that share disorders with SLCO4C1           About GenesLikeMe

    Genetic Association Database (GAD): SLCO4C1
    Human Genome Epidemiology (HuGE) Navigator: SLCO4C1 (7 documents)

    Export disorders for SLCO4C1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLCO4C1 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with SLCO4C1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. (PubMed id 14993604)1, 2, 7, 9 Mikkaichi T.... Abe T. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain. (PubMed id 19197249)1, 4 Tripodi G....Manunta P. (Am. J. Hypertens. 2009)
    4. Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein. (PubMed id 17314201)2, 9 Chu X.-Y.... Evers R. (J. Pharmacol. Exp. Ther. 2007)
    5. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    6. Comparative clinical pharmacokinetics of dipeptidyl peptidase-4 inhibitors. (PubMed id 22686547)7 Golightly L.K....McDermott M.T. (Clin Pharmacokinet 2012)
    7. Genetic variation in solute carrier genes is associated with preeclampsia. (PubMed id 20691413)1 Morrison A.C....Puschett J.B. (Am. J. Obstet. Gynecol. 2010)
    8. Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1. (PubMed id 20610891)1 Yamaguchi H....Mano N. (Drug Metab. Pharmacokinet. 2010)
    9. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    10. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 353189 HGNC: 23612 AceView: SLCO4C1 Ensembl:ENSG00000173930 euGenes: HUgn353189
    ECgene: SLCO4C1 H-InvDB: SLCO4C1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLCO4C1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLCO4C1 gene:
    Search GeneIP for patents involving SLCO4C1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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