Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLCO4C1 Gene

Aliases for SLCO4C1 Gene

  • Solute Carrier Organic Anion Transporter Family, Member 4C1 2 3
  • OATP4C1 3 4 6
  • Solute Carrier Family 21 Member 20 3 4
  • Organic Anion Transporter M1 3 4
  • SLC21A20 3 4
  • OATP-M1 3 4
  • OATP-H 3 4
  • OATPX 3 4
  • Solute Carrier Organic Anion Transporter Family Member 4C1 3
  • PRO2176 3

External Ids for SLCO4C1 Gene

Summaries for SLCO4C1 Gene

Entrez Gene Summary for SLCO4C1 Gene

  • SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 14993604]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLCO4C1 Gene

SLCO4C1 (Solute Carrier Organic Anion Transporter Family, Member 4C1) is a Protein Coding gene. Diseases associated with SLCO4C1 include eastern equine encephalitis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLCO1B7.

UniProtKB/Swiss-Prot for SLCO4C1 Gene

  • Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO4C1 Gene

Genomics for SLCO4C1 Gene

Genomic Location for SLCO4C1 Gene

Start:
102,233,986 bp from pter
End:
102,296,549 bp from pter
Size:
62,564 bases
Orientation:
Minus strand

Genomic View for SLCO4C1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLCO4C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO4C1 Gene

Regulatory Elements for SLCO4C1 Gene

Proteins for SLCO4C1 Gene

  • Protein details for SLCO4C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZQN7-SO4C1_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 4C1
    Protein Accession:
    Q6ZQN7
    Secondary Accessions:
    • Q86UG5

    Protein attributes for SLCO4C1 Gene

    Size:
    724 amino acids
    Molecular mass:
    78948 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • SLCO4C1-mediated digoxin uptake is inhibited by digoxin itself and related compounds such as ouabain, digitoxin and digoxigenin.

neXtProt entry for SLCO4C1 Gene

Proteomics data for SLCO4C1 Gene at MOPED

Post-translational modifications for SLCO4C1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr557

Other Protein References for SLCO4C1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLCO4C1 Gene

Domains for SLCO4C1 Gene

Gene Families for SLCO4C1 Gene

UniProtKB/Swiss-Prot:

SO4C1_HUMAN
Domain:
  • Contains 1 Kazal-like domain.:
    • Q6ZQN7
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.:
    • Q6ZQN7
genes like me logo Genes that share domains with SLCO4C1: view

Function for SLCO4C1 Gene

Molecular function for SLCO4C1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=7.8 uM for digoxin {ECO:0000269 PubMed:14993604}; KM=0.38 uM for ouabain {ECO:0000269 PubMed:14993604}; KM=5.9 uM for thyroxine {ECO:0000269 PubMed:14993604};
UniProtKB/Swiss-Prot Function: Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg.

Gene Ontology (GO) - Molecular Function for SLCO4C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SLCO4C1: view

Phenotypes for SLCO4C1 Gene

GenomeRNAi human phenotypes for SLCO4C1:
genes like me logo Genes that share phenotypes with SLCO4C1: view

miRNA for SLCO4C1 Gene

miRTarBase miRNAs that target SLCO4C1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLCO4C1 Gene

Localization for SLCO4C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO4C1 Gene

Basolateral cell membrane; Multi-pass membrane protein. Note=Detected at the basolateral membrane of the proximal tubule cell in the kidney. {ECO:0000250 UniProtKB:Q71MB6}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLCO4C1 Gene COMPARTMENTS Subcellular localization image for SLCO4C1 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLCO4C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SLCO4C1: view

Pathways for SLCO4C1 Gene

genes like me logo Genes that share pathways with SLCO4C1: view

Interacting Proteins for SLCO4C1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309741%0d%0a9606.ENSP00000260983%0d%0a
Selected Interacting proteins: ENSP00000309741 for SLCO4C1 Gene via STRING

Symbol External ID(s) Details
HECW2

Gene Ontology (GO) - Biological Process for SLCO4C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
GO:0043252 sodium-independent organic anion transport TAS --
genes like me logo Genes that share ontologies with SLCO4C1: view

Compounds for SLCO4C1 Gene

(2) HMDB Compounds for SLCO4C1 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4
Digoxin
  • Cardoxin
20830-75-5

(9) Drugbank Compounds for SLCO4C1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Dextrothyroxine
51-49-0 transporter
Digitoxin
  • Digitoksin
71-63-6 transporter inhibitor
Digoxin
20830-75-5 transporter inhibitor
Levothyroxine
  • (-)-Thyroxine
51-48-9 transporter
Liothyronine
  • L-Liothyronine
6893-02-3 transporter substrate

(1) IUPHAR Ligand for SLCO4C1 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]digoxin None None
genes like me logo Genes that share compounds with SLCO4C1: view

Transcripts for SLCO4C1 Gene

mRNA/cDNA for SLCO4C1 Gene

Unigene Clusters for SLCO4C1 Gene

Solute carrier organic anion transporter family, member 4C1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO4C1 Gene

No ASD Table

Relevant External Links for SLCO4C1 Gene

GeneLoc Exon Structure for
SLCO4C1
ECgene alternative splicing isoforms for
SLCO4C1

Expression for SLCO4C1 Gene

mRNA expression in normal human tissues for SLCO4C1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO4C1 Gene

This gene is overexpressed in Whole Blood (13.7), Kidney - Cortex (11.0), and Lung (8.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLCO4C1 Gene

SOURCE GeneReport for Unigene cluster for SLCO4C1 Gene Hs.127648

mRNA Expression by UniProt/SwissProt for SLCO4C1 Gene

Q6ZQN7-SO4C1_HUMAN
Tissue specificity: Predominantly expressed in kidney but also weakly expressed in both fetal liver and kidney.
genes like me logo Genes that share expressions with SLCO4C1: view

Orthologs for SLCO4C1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLCO4C1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLCO4C1 36
  • 99.26 (n)
  • 99.45 (a)
SLCO4C1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLCO4C1 36
  • 81.39 (n)
  • 74.19 (a)
SLCO4C1 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLCO4C1 36
  • 86.59 (n)
  • 81.43 (a)
SLCO4C1 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slco4c1 36
  • 81.92 (n)
  • 80.75 (a)
Slco4c1 16
Slco4c1 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLCO4C1 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slco4c1 36
  • 80.53 (n)
  • 80.36 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 63 (a)
OneToMany
SLCO4C1 36
  • 67.69 (n)
  • 65.9 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 43 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slco4c1 36
  • 64.07 (n)
  • 59.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta Oatp33Eb 37
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F53B1.8 36
  • 44.09 (n)
  • 33.03 (a)
F53B1.8 37
  • 25 (a)
ManyToMany
K02G10.5 37
  • 25 (a)
ManyToMany
Y70G10A.3 37
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
ManyToMany
-- 37
  • 38 (a)
ManyToMany
-- 37
  • 41 (a)
ManyToMany
Species with no ortholog for SLCO4C1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLCO4C1 Gene

ENSEMBL:
Gene Tree for SLCO4C1 (if available)
TreeFam:
Gene Tree for SLCO4C1 (if available)

Paralogs for SLCO4C1 Gene

Selected SIMAP similar genes for SLCO4C1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLCO4C1: view

Variants for SLCO4C1 Gene

Sequence variations from dbSNP and Humsavar for SLCO4C1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs174414 -- 102,257,038(-) CTTAA(A/G)TGGTG intron-variant
rs261098 -- 102,258,642(-) ATACT(A/C)CCCTC intron-variant
rs261099 -- 102,258,495(-) CATCT(C/G)TGCTC intron-variant
rs261100 -- 102,258,482(-) AGTCT(C/T)AAACT intron-variant
rs261101 -- 102,257,105(-) ATACA(A/T)TTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO4C1 Gene

Variant ID Type Subtype PubMed ID
nsv882505 CNV Loss 21882294
nsv507279 CNV Insertion 20534489
nsv522882 CNV Loss 19592680
esv268733 CNV Insertion 20981092
esv2678701 CNV Deletion 23128226

Relevant External Links for SLCO4C1 Gene

HapMap Linkage Disequilibrium report
SLCO4C1

Disorders for SLCO4C1 Gene

(1) University of Copenhagen DISEASES for SLCO4C1 Gene

Relevant External Links for SLCO4C1

Genetic Association Database (GAD)
SLCO4C1
Human Genome Epidemiology (HuGE) Navigator
SLCO4C1
genes like me logo Genes that share disorders with SLCO4C1: view

No data available for UniProtKB/Swiss-Prot for SLCO4C1 Gene

Publications for SLCO4C1 Gene

  1. Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. (PMID: 14993604) Mikkaichi T. … Abe T. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23 25
  2. Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein. (PMID: 17314201) Chu X.-Y. … Evers R. (J. Pharmacol. Exp. Ther. 2007) 4 23
  3. Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain. (PMID: 19197249) Tripodi G. … Manunta P. (Am. J. Hypertens. 2009) 3 49
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  5. Genetic variation in solute carrier genes is associated with preeclampsia. (PMID: 20691413) Morrison A.C. … Puschett J.B. (Am. J. Obstet. Gynecol. 2010) 3

Products for SLCO4C1 Gene

Sources for SLCO4C1 Gene

Back to Top

Content