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Aliases for SLCO4A1 Gene

Aliases for SLCO4A1 Gene

  • Solute Carrier Organic Anion Transporter Family, Member 4A1 2 3
  • OATP4A1 3 4 6
  • OATPE 3 4 6
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 12 2 3
  • Organic Anion Transporter Polypeptide-Related Protein 1 3 4
  • Sodium-Independent Organic Anion Transporter E 3 4
  • Organic Anion-Transporting Polypeptide E 3 4
  • Solute Carrier Family 21 Member 12 3 4
  • Colon Organic Anion Transporter 3 4
  • SLC21A12 3 4
  • OATP-RP1 3 4
  • OATPRP1 3 4
  • OATP-E 3 4
  • OATP1 3 4
  • POAT 3 4
  • Solute Carrier Organic Anion Transporter Family Member 4A1 3
  • Organic Anion Transporting Polypeptide E 3

External Ids for SLCO4A1 Gene

Previous Symbols for SLCO4A1 Gene

  • SLC21A12

Summaries for SLCO4A1 Gene

GeneCards Summary for SLCO4A1 Gene

SLCO4A1 (Solute Carrier Organic Anion Transporter Family, Member 4A1) is a Protein Coding gene. Diseases associated with SLCO4A1 include aneurysmal bone cysts and mucinous cystadenocarcinoma. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLCO1B7.

UniProtKB/Swiss-Prot for SLCO4A1 Gene

  • Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate

Gene Wiki entry for SLCO4A1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO4A1 Gene

Genomics for SLCO4A1 Gene

Genomic Location for SLCO4A1 Gene

Start:
62,642,443 bp from pter
End:
62,685,785 bp from pter
Size:
43,343 bases
Orientation:
Plus strand

Genomic View for SLCO4A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLCO4A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO4A1 Gene

Regulatory Elements for SLCO4A1 Gene

Proteins for SLCO4A1 Gene

  • Protein details for SLCO4A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BD0-SO4A1_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 4A1
    Protein Accession:
    Q96BD0
    Secondary Accessions:
    • Q9H4T7
    • Q9H4T8
    • Q9H8P2
    • Q9NWX8
    • Q9UI35
    • Q9UIG7

    Protein attributes for SLCO4A1 Gene

    Size:
    722 amino acids
    Molecular mass:
    77193 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91247.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLCO4A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLCO4A1 Gene

Proteomics data for SLCO4A1 Gene at MOPED

Post-translational modifications for SLCO4A1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys66 and Lys353
  • Glycosylation at Asn499 and Asn557

Other Protein References for SLCO4A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLCO4A1 Gene

Domains for SLCO4A1 Gene

Gene Families for SLCO4A1 Gene

UniProtKB/Swiss-Prot:

SO4A1_HUMAN
Domain:
  • Contains 1 Kazal-like domain.:
    • Q96BD0
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.:
    • Q96BD0
genes like me logo Genes that share domains with SLCO4A1: view

Function for SLCO4A1 Gene

Molecular function for SLCO4A1 Gene

UniProtKB/Swiss-Prot Function: Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate

Gene Ontology (GO) - Molecular Function for SLCO4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SLCO4A1: view

Phenotypes for SLCO4A1 Gene

GenomeRNAi human phenotypes for SLCO4A1:
genes like me logo Genes that share phenotypes with SLCO4A1: view

miRNA for SLCO4A1 Gene

miRTarBase miRNAs that target SLCO4A1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLCO4A1 Gene

Localization for SLCO4A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO4A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLCO4A1 Gene COMPARTMENTS Subcellular localization image for SLCO4A1 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SLCO4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLCO4A1: view

Pathways for SLCO4A1 Gene

genes like me logo Genes that share pathways with SLCO4A1: view

Interacting Proteins for SLCO4A1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000217159%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000217159 Q96BD0-SO4A1_HUMAN for SLCO4A1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLCO4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0043252 sodium-independent organic anion transport TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLCO4A1: view

Compounds for SLCO4A1 Gene

(86) HMDB Compounds for SLCO4A1 Gene

Compound Synonyms Cas Number PubMed IDs
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
58814-71-4
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-oate
63266-91-1
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-oate
63266-89-7
12a-Hydroxy-3-oxocholadienic acid
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oate
13535-96-1
12b-Hydroxy-5b-cholanoic acid
  • 12b-Hydroxy-5b-cholanic acid
15173-23-6

(10) Drugbank Compounds for SLCO4A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Conjugated Estrogens
  • Estrogens
438-67-5 transporter substrate
Dextrothyroxine
51-49-0 transporter
Digoxin
20830-75-5 transporter substrate
Dinoprostone
  • Dinoprostone Prostaglandin E2
363-24-6 transporter substrate
Estradiol
  • 17beta oestradiol
50-28-2 transporter

(1) IUPHAR Ligand for SLCO4A1 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]estrone-3-sulphate None None

(2) Novoseek inferred chemical compound relationships for SLCO4A1 Gene

Compound -log(P) Hits PubMed IDs
oatp 90.7 7
taurocholate 67.9 1
genes like me logo Genes that share compounds with SLCO4A1: view

Transcripts for SLCO4A1 Gene

Unigene Clusters for SLCO4A1 Gene

Solute carrier organic anion transporter family, member 4A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO4A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
SP1: - - - - -
SP2: - - - - - - - - - -
SP3:
SP4: - - - - - -
SP5: -
SP6: -
SP7:

Relevant External Links for SLCO4A1 Gene

GeneLoc Exon Structure for
SLCO4A1
ECgene alternative splicing isoforms for
SLCO4A1

Expression for SLCO4A1 Gene

mRNA expression in normal human tissues for SLCO4A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLCO4A1 Gene

SOURCE GeneReport for Unigene cluster for SLCO4A1 Gene Hs.235782

mRNA Expression by UniProt/SwissProt for SLCO4A1 Gene

Q96BD0-SO4A1_HUMAN
Tissue specificity: Ubiquitous, with the exception of spleen and leukocytes
genes like me logo Genes that share expressions with SLCO4A1: view

Orthologs for SLCO4A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLCO4A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLCO4A1 36
  • 98.59 (n)
  • 98.98 (a)
SLCO4A1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLCO4A1 36
  • 83.55 (n)
  • 80.11 (a)
SLCO4A1 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLCO4A1 36
  • 83.05 (n)
  • 80 (a)
SLCO4A1 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slco4a1 36
  • 79.66 (n)
  • 76.72 (a)
Slco4a1 16
Slco4a1 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLCO4A1 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLCO4A1 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slco4a1 36
  • 78.87 (n)
  • 75.63 (a)
chicken
(Gallus gallus)
Aves SLCO4A1 36
  • 70.18 (n)
  • 70.91 (a)
SLCO4A1 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLCO4A1 37
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slco4a1 36
  • 66.12 (n)
  • 66.28 (a)
zebrafish
(Danio rerio)
Actinopterygii slco4a1 36
  • 64.76 (n)
  • 65.28 (a)
slco4a1 37
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008712 36
  • 55.95 (n)
  • 50.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta Oatp26F 36
  • 56.11 (n)
  • 46.12 (a)
Oatp26F 37
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y70G10A.3 36
  • 46.75 (n)
  • 37.95 (a)
F53B1.8 37
  • 26 (a)
ManyToMany
K02G10.5 37
  • 27 (a)
ManyToMany
Y70G10A.3 37
  • 33 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
OneToOne
Species with no ortholog for SLCO4A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLCO4A1 Gene

ENSEMBL:
Gene Tree for SLCO4A1 (if available)
TreeFam:
Gene Tree for SLCO4A1 (if available)

Paralogs for SLCO4A1 Gene

Selected SIMAP similar genes for SLCO4A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLCO4A1: view

Variants for SLCO4A1 Gene

Sequence variations from dbSNP and Humsavar for SLCO4A1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs872626 -- 62,659,008(+) CTAAG(C/T)GCTTG intron-variant
rs1047099 - 62,656,686(+) GGTAC(A/G)TCTCG missense, reference, nc-transcript-variant
rs1055196 -- 62,672,214(+) GGCGG(C/T)GGGCC utr-variant-3-prime, intron-variant, downstream-variant-500B
rs1815591 -- 62,645,662(+) TTTTC(A/T)AACCA intron-variant
rs2185089 -- 62,678,188(+) AGAAA(C/T)GCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO4A1 Gene

Variant ID Type Subtype PubMed ID
esv2422398 CNV Duplication 17116639
dgv4603n71 CNV Loss 21882294
nsv459065 CNV Gain 19166990
nsv913073 CNV Loss 21882294
dgv1343e1 CNV Complex 17122850
nsv428380 CNV Loss 18775914
nsv834026 CNV Loss 17160897
nsv913106 CNV Loss 21882294
esv2722820 CNV Deletion 23290073
esv2722821 CNV Deletion 23290073
esv994234 CNV Deletion 20482838
esv1387013 CNV Deletion 17803354
nsv913108 CNV Loss 21882294
nsv9822 CNV Gain 18304495

Relevant External Links for SLCO4A1 Gene

HapMap Linkage Disequilibrium report
SLCO4A1

Disorders for SLCO4A1 Gene

(1) University of Copenhagen DISEASES for SLCO4A1 Gene

Relevant External Links for SLCO4A1

Genetic Association Database (GAD)
SLCO4A1
Human Genome Epidemiology (HuGE) Navigator
SLCO4A1
genes like me logo Genes that share disorders with SLCO4A1: view

No data available for UniProtKB/Swiss-Prot for SLCO4A1 Gene

Publications for SLCO4A1 Gene

  1. Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. (PMID: 11316767) Fujiwara K. … Abe T. (Endocrinology 2001) 3 4 23 25
  2. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (PMID: 10873595) Tamai I. … Tsuji A. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 25
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SLCO4A1 Gene

Sources for SLCO4A1 Gene

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