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Aliases for SLCO4A1 Gene

Aliases for SLCO4A1 Gene

  • Solute Carrier Organic Anion Transporter Family, Member 4A1 2 3
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 12 2 3
  • Organic Anion Transporter Polypeptide-Related Protein 1 3 4
  • Sodium-Independent Organic Anion Transporter E 3 4
  • Organic Anion-Transporting Polypeptide E 3 4
  • Solute Carrier Family 21 Member 12 3 4
  • Colon Organic Anion Transporter 3 4
  • SLC21A12 3 4
  • OATP-RP1 3 4
  • OATP4A1 3 4
  • OATPRP1 3 4
  • OATP-E 3 4
  • OATP1 3 4
  • OATPE 3 4
  • POAT 3 4
  • Organic Anion Transporting Polypeptide E 3

External Ids for SLCO4A1 Gene

Previous HGNC Symbols for SLCO4A1 Gene

  • SLC21A12

Previous GeneCards Identifiers for SLCO4A1 Gene

  • GC20P062000
  • GC20P060744
  • GC20P061273
  • GC20P057991
  • GC20P062655

Summaries for SLCO4A1 Gene

GeneCards Summary for SLCO4A1 Gene

SLCO4A1 (Solute Carrier Organic Anion Transporter Family, Member 4A1) is a Protein Coding gene. Diseases associated with SLCO4A1 include aneurysmal bone cysts. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of vitamins, nucleosides, and related molecules. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLCO1B7.

UniProtKB/Swiss-Prot for SLCO4A1 Gene

  • Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate

Gene Wiki entry for SLCO4A1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO4A1 Gene

Genomics for SLCO4A1 Gene

Regulatory Elements for SLCO4A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLCO4A1 Gene

Chromosome:
20
Start:
62,642,445 bp from pter
End:
62,685,830 bp from pter
Size:
43,386 bases
Orientation:
Plus strand

Genomic View for SLCO4A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLCO4A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO4A1 Gene

Proteins for SLCO4A1 Gene

  • Protein details for SLCO4A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BD0-SO4A1_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 4A1
    Protein Accession:
    Q96BD0
    Secondary Accessions:
    • Q9H4T7
    • Q9H4T8
    • Q9H8P2
    • Q9NWX8
    • Q9UI35
    • Q9UIG7

    Protein attributes for SLCO4A1 Gene

    Size:
    722 amino acids
    Molecular mass:
    77193 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91247.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLCO4A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLCO4A1 Gene

Proteomics data for SLCO4A1 Gene at MOPED

Post-translational modifications for SLCO4A1 Gene

  • Ubiquitination at Lys 66 and Lys 353
  • Glycosylation at Asn 499 and Asn 557
  • Modification sites at PhosphoSitePlus

Other Protein References for SLCO4A1 Gene

No data available for DME Specific Peptides for SLCO4A1 Gene

Domains & Families for SLCO4A1 Gene

Gene Families for SLCO4A1 Gene

Suggested Antigen Peptide Sequences for SLCO4A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BD0

UniProtKB/Swiss-Prot:

SO4A1_HUMAN :
  • Contains 1 Kazal-like domain.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
Domain:
  • Contains 1 Kazal-like domain.
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO4A1: view

Function for SLCO4A1 Gene

Molecular function for SLCO4A1 Gene

UniProtKB/Swiss-Prot Function:
Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate

Gene Ontology (GO) - Molecular Function for SLCO4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005515 protein binding --
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA --
GO:0015349 thyroid hormone transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLCO4A1: view
genes like me logo Genes that share phenotypes with SLCO4A1: view

Animal Model Products

CRISPR Products

miRNA for SLCO4A1 Gene

miRTarBase miRNAs that target SLCO4A1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLCO4A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLCO4A1 Gene

Localization for SLCO4A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO4A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLCO4A1 Gene COMPARTMENTS Subcellular localization image for SLCO4A1 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SLCO4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLCO4A1: view

Pathways & Interactions for SLCO4A1 Gene

genes like me logo Genes that share pathways with SLCO4A1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SLCO4A1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000217159%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q96BD0-SO4A1_HUMAN ENSP00000217159 for SLCO4A1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for SLCO4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport --
GO:0042403 thyroid hormone metabolic process IEA --
GO:0043252 sodium-independent organic anion transport TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLCO4A1: view

No data available for SIGNOR curated interactions for SLCO4A1 Gene

Drugs & Compounds for SLCO4A1 Gene

(17) Drugs for SLCO4A1 Gene - From: IUPHAR, DGIdb, DrugBank, HMDB, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Liotrix Approved Pharma Transporter, substrate, inhibitor 0
Penicillin G Approved Pharma Transporter, substrate 25
Conjugated Estrogens Approved Pharma Transporter, substrate 0
Dextrothyroxine Approved Pharma Transporter 0
Digoxin Approved Pharma Transporter, substrate Na+/K+ ATPase inhibitor 118

(82) Additional Compounds for SLCO4A1 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
  • Chenodeoxycholic acid-3-b-D-glucuronide
  • Chenodeoxycholic acid-3-beta-delta-glucuronide
58814-71-4
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxy-5b-Cholanoate
  • 1,3,12-Trihydroxy-5b-Cholanoic acid
  • 1,3,12-Trihydroxy-Cholan-24-oate
  • 1,3,12-Trihydroxy-Cholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-oate
63266-91-1
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oate
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-oate
  • 1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholanoate
63266-89-7
12a-Hydroxy-3-oxocholadienic acid
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oate
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oic acid
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienate
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienic acid
  • 12a-Hydroxy-3-oxochola-4,6-dienate
13535-96-1
12b-Hydroxy-5b-cholanoic acid
  • 12-Hydroxy-(5b,12b)-Cholan-24-oate
  • 12-Hydroxy-(5b,12b)-Cholan-24-oic acid
  • 12b-Hydroxy-5b-Cholan-24-oate
  • 12b-Hydroxy-5b-Cholan-24-oic acid
  • 12b-Hydroxy-5b-cholanic acid
15173-23-6
genes like me logo Genes that share compounds with SLCO4A1: view

Transcripts for SLCO4A1 Gene

Unigene Clusters for SLCO4A1 Gene

Solute carrier organic anion transporter family, member 4A1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLCO4A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO4A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
SP1: - - - - -
SP2: - - - - - - - - - -
SP3:
SP4: - - - - - -
SP5: -
SP6: -
SP7:

Relevant External Links for SLCO4A1 Gene

GeneLoc Exon Structure for
SLCO4A1
ECgene alternative splicing isoforms for
SLCO4A1

Expression for SLCO4A1 Gene

mRNA expression in normal human tissues for SLCO4A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLCO4A1 Gene

This gene is overexpressed in Placenta (65.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SLCO4A1 Gene



SOURCE GeneReport for Unigene cluster for SLCO4A1 Gene Hs.235782

mRNA Expression by UniProt/SwissProt for SLCO4A1 Gene

Q96BD0-SO4A1_HUMAN
Tissue specificity: Ubiquitous, with the exception of spleen and leukocytes
genes like me logo Genes that share expression patterns with SLCO4A1: view

Protein tissue co-expression partners for SLCO4A1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLCO4A1 Gene

Orthologs for SLCO4A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLCO4A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLCO4A1 35
  • 83.55 (n)
  • 80.11 (a)
SLCO4A1 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLCO4A1 35
  • 83.05 (n)
  • 80 (a)
SLCO4A1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slco4a1 35
  • 79.66 (n)
  • 76.72 (a)
Slco4a1 16
Slco4a1 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLCO4A1 35
  • 98.59 (n)
  • 98.98 (a)
SLCO4A1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slco4a1 35
  • 78.87 (n)
  • 75.63 (a)
oppossum
(Monodelphis domestica)
Mammalia SLCO4A1 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLCO4A1 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLCO4A1 35
  • 70.18 (n)
  • 70.91 (a)
SLCO4A1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLCO4A1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slco4a1 35
  • 66.12 (n)
  • 66.28 (a)
zebrafish
(Danio rerio)
Actinopterygii slco4a1 35
  • 64.76 (n)
  • 65.28 (a)
slco4a1 36
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008712 35
  • 55.95 (n)
  • 50.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta Oatp26F 35
  • 56.11 (n)
  • 46.12 (a)
Oatp26F 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y70G10A.3 35
  • 46.75 (n)
  • 37.95 (a)
F53B1.8 36
  • 26 (a)
ManyToMany
K02G10.5 36
  • 27 (a)
ManyToMany
Y70G10A.3 36
  • 33 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToOne
Species with no ortholog for SLCO4A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLCO4A1 Gene

ENSEMBL:
Gene Tree for SLCO4A1 (if available)
TreeFam:
Gene Tree for SLCO4A1 (if available)

Paralogs for SLCO4A1 Gene

(13) SIMAP similar genes for SLCO4A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLCO4A1: view

Variants for SLCO4A1 Gene

Sequence variations from dbSNP and Humsavar for SLCO4A1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs872626 -- 62,659,008(+) CTAAG(C/T)GCTTG intron-variant
rs1055196 -- 62,672,214(+) GGCGG(C/T)GGGCC utr-variant-3-prime, intron-variant, downstream-variant-500B, nc-transcript-variant
rs1815591 -- 62,645,662(+) TTTTC(A/T)AACCA intron-variant
rs2185089 -- 62,678,188(+) AGAAA(C/T)GCCAG intron-variant
rs2236553 -- 62,658,391(+) CTGTG(C/T)GGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO4A1 Gene

Variant ID Type Subtype PubMed ID
esv2422398 CNV Duplication 17116639
dgv4603n71 CNV Loss 21882294
nsv459065 CNV Gain 19166990
nsv913073 CNV Loss 21882294
dgv1343e1 CNV Complex 17122850
nsv428380 CNV Loss 18775914
nsv834026 CNV Loss 17160897
nsv913106 CNV Loss 21882294
esv2722820 CNV Deletion 23290073
esv2722821 CNV Deletion 23290073
esv994234 CNV Deletion 20482838
esv1387013 CNV Deletion 17803354
nsv913108 CNV Loss 21882294
nsv9822 CNV Gain 18304495

Variation tolerance for SLCO4A1 Gene

Residual Variation Intolerance Score: 90.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.17; 75.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLCO4A1 Gene

HapMap Linkage Disequilibrium report
SLCO4A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO4A1 Gene

Disorders for SLCO4A1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLCO4A1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
aneurysmal bone cysts
  • bone cysts aneurysmal
- elite association

Relevant External Links for SLCO4A1

Genetic Association Database (GAD)
SLCO4A1
Human Genome Epidemiology (HuGE) Navigator
SLCO4A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLCO4A1
genes like me logo Genes that share disorders with SLCO4A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLCO4A1 Gene

Publications for SLCO4A1 Gene

  1. Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. (PMID: 11316767) Fujiwara K. … Abe T. (Endocrinology 2001) 23 25 26 67
  2. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (PMID: 10873595) Tamai I. … Tsuji A. (Biochem. Biophys. Res. Commun. 2000) 2 25 26 67
  3. Molecular characterization of a new ovarian cancer cell line, YDOV-151, established from mucinous cystadenocarcinoma. (PMID: 19478469) Cho H. … Kim J.H. (Tohoku J. Exp. Med. 2009) 23 67
  4. Different expression patterns of organic anion transporting polypeptides in osteosarcomas, bone metastases and aneurysmal bone cysts. (PMID: 19885603) Liedauer R. … Thalhammer T. (Oncol. Rep. 2009) 23 67
  5. Changes in mRNA expression levels of solute carrier transporters in inflammatory bowel disease patients. (PMID: 19487253) Wojtal K.A. … Vavricka S.R. (Drug Metab. Dispos. 2009) 23 67

Products for SLCO4A1 Gene

Sources for SLCO4A1 Gene

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