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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLCO4A1 Gene

protein-coding   GIFtS: 59
GCID: GC20P061273

solute carrier organic anion transporter family, member...

(Previous names: solute carrier family 21 (organic anion transporter), member...)
(Previous symbol: SLC21A12)
 Explore 11 diseases affiliated with
SLCO4A1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLCO4A1    

Aliases
for SLCO4A1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Organic Anion Transporter Family, Member 4A11 2     Sodium-Independent Organic Anion Transporter E2 3
OATP4A11 2 3 5     Solute Carrier Family 21 Member 122 3
OATP-E1 2 3     OATP-RP12 3
SLC21A121 2 3     OATP12 3
OATPE2 3 5     OATPRP12 3
Solute Carrier Family 21 (Organic Anion Transporter), Member 121 2     POAT2 3
Colon Organic Anion Transporter2 3     Organic Anion Transporting Polypeptide E2
Organic Anion Transporter Polypeptide-Related Protein 12 3     Solute Carrier Organic Anion Transporter Family Member 4A12
Organic Anion-Transporting Polypeptide E2 3     

External Ids:    HGNC: 109531   Entrez Gene: 282312   Ensembl: ENSG000001011877   OMIM: 6124365   UniProtKB: Q96BD03   

Export aliases for SLCO4A1 gene to outside databases

Previous GC identifers: GC20P062000 GC20P060744 GC20P057991


Summaries
for SLCO4A1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SO4A1_HUMAN, Q96BD0
Function: Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3
(triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate

Gene Wiki entry for SLCO4A1


Genomic Views
for SLCO4A1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011333.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLCO4A1 gene promoter:
         AhR   p53   Tal-1beta   E47   Arnt   HNF-1A   HNF-1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLCO4A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLCO4A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLCO4A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.1

SLCO4A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO4A1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P061273:  view genomic region     (about GC identifiers)

Start:
 61,273,797 bp from pter      End:
 61,317,137 bp from pter
Size:
 43,341 bases      Orientation:
 plus strand

Proteins
for SLCO4A1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SO4A1_HUMAN, Q96BD0 (See protein sequence)
Recommended Name: Solute carrier organic anion transporter family member 4A1  
Size: 722 amino acids; 77193 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAA91247.1; Type=Erroneous initiation;
Secondary accessions: Q9H4T7 Q9H4T8 Q9H8P2 Q9NWX8 Q9UI35 Q9UIG7
Alternative splicing: 4 isoforms:  Q96BD0-1   Q96BD0-2   Q96BD0-3   Q96BD0-4   

Explore the universe of human proteins at neXtProt for SLCO4A1: NX_Q96BD0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96BD0

    • SLCO4A1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057438.3  
    ENSEMBL proteins: 
     ENSP00000434245   ENSP00000359538   ENSP00000414855   ENSP00000217159  
    Reactome Protein details: Q96BD0
    Human Recombinant Protein Products: 
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    Novus Biologicals SLCO4A1 Lysate
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    Uscn Proteins for SLCO4A1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--


    SLCO4A1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLCO4A1

    Protein Domains /
    Families
    for SLCO4A1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLCO4A1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR002350 Prot_inh_Kazal
     IPR004156 OA_transporter
     IPR020846 MFS_dom
     IPR011497 Kazal-type_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q96BD0

    ProtoNet protein and cluster: Q96BD0

    2 Blocks protein families:
    IPB004156 Organic anion transporter polypeptide (OATP)
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: SO4A1_HUMAN, Q96BD0
    Similarity: Belongs to the organo anion transporter (TC 2.A.60) family
    Similarity: Contains 1 Kazal-like domain


    Function
    for SLCO4A1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SO4A1_HUMAN, Q96BD0
    Function: Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3
    (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate

    miRNA
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    Inhib. RNA
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0015349thyroid hormone transmembrane transporter activity ----


    SLCO4A1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SLCO4A1:
     Increased HPV18 LCR reporter a 


    Pathways & Interactions
    for SLCO4A1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transport of organic anions
    		Transport of organic anions1.00
    		Transport of vitamins, nucleosides, and related molecules0.35
    2SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50
    3Hepatic ABC Transporters
    		Hepatic ABC Transporters1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SLCO4A1
        Hepatic ABC Transporters

    4        Reactome Pathways for SLCO4A1
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of vitamins, nucleosides, and related molecules
    Transport of organic anions



    SLCO4A1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLCO4A1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for SLCO4A1 (Q96BD03 ENSP000002171594) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631043I2D: score=3 
    MTMR9Q96QG73I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042403thyroid hormone metabolic process ----
    GO:0043252sodium-independent organic anion transport TAS--
    GO:0055085transmembrane transport TAS--
    GO:0070327thyroid hormone transport ----


    SLCO4A1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLCO4A1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLCO4A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLCO4A1

    10/86 HMDB Compounds for SLCO4A1 (see all 86)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acidChenodeoxycholic acid 3-glucuronide (see all 3)58814-71-4--
    1,3,12-Trihydroxycholan-24-oic acid1,3,12-Trihydroxycholan-24-oate (see all 6)63266-91-1--
    1,3,7,12-Tetrahydroxycholan-24-oic acid1,3,7,12-Tetrahydroxycholan-24-oate (see all 10)63266-89-7--
    12-Ketodeoxycholic acid12-Dehydrodeoxycholate (see all 20)5130-29-0--
    12a-Hydroxy-3-oxocholadienic acid12a-Hydroxy-3-oxo-4,6-choladien-24-oate (see all 8)13535-96-1--
    12b-Hydroxy-5b-cholanoic acid12b-Hydroxy-5b-cholanic acid (see all 9)15173-23-6--
    1b,3a,12a-Trihydroxy-5b-cholanoic acid1,3,12-trihydroxy-(5b)-Cholan-24-oate (see all 6)80434-32-8--
    1b,3a,7a-Trihydroxy-5b-cholanoic acid1 beta,3a,7a-Trihydroxy-5b-cholanoate (see all 18)99598-04-6--
    1b-Hydroxycholic acid1b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 5)80875-94-1--
    2b,3a,7a,12a-Tetrahydroxy-5b-cholanoic acid2b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 7)60696-60-8--

    7 DrugBank Compounds for SLCO4A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    LiothyronineL-Liothyronine (see all 5)6893-02-3transportersubstrate inhibitor11316767 14993604
    Liotrix-- 8065-29-0transportersubstrate inhibitor11316767 14993604
    Conjugated EstrogensEstrogens (see all 10)438-67-5transportersubstrate10873595
    Digoxin-- 20830-75-5transportersubstrate14993604
    DinoprostoneDinoprostone Prostaglandin E2 (see all 3)363-24-6transportersubstrate10873595
    Penicillin G-- 61-33-6transportersubstrate10873595
    Taurocholic Acid-- 81-24-3transporterinhibitor11316767

    2 Novoseek chemical compound relationships for SLCO4A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oatp 90.7 14 11316767 (4), 12542534 (2), 19885603 (1)
    taurocholate 67.9 1 16637898 (1)

    Search CenterWatch for drugs/clinical trials and news about SLCO4A1 / SO4A1 

    Transcripts
    for SLCO4A1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLCO4A1 gene: 
    NM_016354.3  

    Unigene Cluster for SLCO4A1:

    Solute carrier organic anion transporter family, member 4A1
    Hs.235782  [show with all ESTs]
    Unigene Representative Sequence: NM_016354
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497209 ENST00000370507 ENST00000470412 ENST00000495889 ENST00000466961
    ENST00000451793 ENST00000497919 ENST00000466818 ENST00000217159(uc002ydb.1 uc002yde.1)


    miRNA
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB031051.1 AF187817.1 AF205072.1 AK000551.1 AK023410.1 BC015727.1 

    12 DOTS entries:

    DT.212594  DT.100743380  DT.95102841  DT.95148575  DT.100840473  DT.101975909  DT.95102799  DT.100744646 
    DT.101977556  DT.92428716  DT.97858867  DT.97765643 

    24/138 AceView cDNA sequences (see all 138):

    AI276796 BU196388 BX645582 BU543183 AW614640 BQ924684 BQ918647 BQ948972 
    AK095985 F29712 BU543102 BX483888 BM703715 BX105765 BU502596 BM757403 
    BE501491 BM759272 AB031051 AI027850 BI860613 BP360141 BG681711 BE251142 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SLCO4A1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
    SP1:                                -     -                                         -                 -     -                     
    SP2:                                      -     -     -           -     -           -                 -     -     -     -         
    SP3:                                                                                                                              
    SP4:                                                              -     -     -     -                 -     -                     
    SP5:                                                                                -                                             


    ECgene alternative splicing isoforms for SLCO4A1

    Expression
    for SLCO4A1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLCO4A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGCTCCTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLCO4A1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeInterscapular Brown Adipose DepotAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See SLCO4A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLCO4A1

    SOURCE GeneReport for Unigene cluster: Hs.235782

    UniProtKB/Swiss-Prot: SO4A1_HUMAN, Q96BD0
    Tissue specificity: Ubiquitous, with the exception of spleen and leukocytes

        SABiosciences Expression via Pathway-Focused PCR Array including SLCO4A1: 
              Drug Transporters in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for SLCO4A1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLCO4A1 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLCO4A11 solute carrier organic anion transporter family, member more 70.06(n)
    70.18(a)    		   419231  NM_001030856.1  NP_001026027.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SLCO4A16
    		 --
    		 65(a)
    		 1 ↔ 1
    		 4(152048874-152074083)
    zebrafish
    (Danio rerio)    		 Actinopterygii slco4a11 solute carrier organic anion transporter family, member more 64.83(n)
    65.8(a)    		   567865  XM_691171.2  XP_696263.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Oatp26F1 Organic anion transporting polypeptide 26F 56.01(n)
    46.24(a)    		   33927  NM_135211.2  NP_609055.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_Y70G10A.31 Protein Y70G10A.3 46.75(n)
    37.95(a)    		   190573  NM_066866.1  NP_499267.1 


    ENSEMBL Gene Tree for SLCO4A1 (if available)
    TreeFam Gene Tree for SLCO4A1 (if available) 

    Paralogs
    for SLCO4A1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLCO4A1 gene
    SLCO2A12  SLCO4C12  SLCO1B72  ENSG000002570622  SLCO1B32  SLCO3A12  SLCO5A12  SLCO2B12  
    SLCO6A12  SLCO1B12  ENSG000002570462  SLCO1A22  SLCO1C12  
    13 SIMAP similar genes for SLCO4A1 using alignment to 2 protein entries:     SO4A1_HUMAN (see all proteins):
    SLCO4C1    SLCO2A1    SLCO1B3    SLCO6A1    SLC21A8    SLCO2B1
    SLCO5A1    SLCO1B1    LST3    SLCO1A2    SLCO1B7    SLCO1C1
    SLCO3A1

    SLCO4A1 for paralogs           About GeneDecksing



    Genomic Variants
    for SLCO4A1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/759 NCBI SNPs in SLCO4A1 are shown (see all 759)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs739183781,2
    		C,--57989441(+) AGGACC/TGAGGG 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs60904451,2
    		C,--57989975(+) GAGGCC/TAGGTC 1 -- nc-transcript-variant4Minor allele frequency- T:0.07WA CSA NA 241
    rs81157551,2
    		C,F,A,--57990034(+) GTGCAC/TCTTCC 1 -- nc-transcript-variant1Minor allele frequency- T:0.02WA 118
    rs799570521,2
    		C,--57990401(+) CACGCT/CATGCC 1 -- nc-transcript-variant2Minor allele frequency- C:0.06WA 120
    rs1146705201,2
    		C,F,--57990482(+) CATTTC/ACCCCC 1 -- nc-transcript-variant1Minor allele frequency- A:0.03WA 118
    rs792527631,2
    		C,--57991114(+) CAGCGC/TCCAGG 1 -- nc-transcript-variant0--------
    rs744558501,2
    		C,F,--57991235(+) GAGCGG/CGGAGT 1 -- nc-transcript-variant2Minor allele frequency- C:0.09NA EA 240
    rs81177201,2
    		A--57992097(+) GGGCTA/GGTTTC 1 -- nc-transcript-variant0--------
    rs81177281,2
    		A--57992136(+) CCACCA/GCGCGA 1 -- nc-transcript-variant0--------
    rs81221871,2
    		A--57992195(+) AGAGGG/TTCGGG 1 -- nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for SLCO4A1 (61273797 - 61317137 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for SLCO4A1
         3 CNVs: 4106 5347 5144

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    Disorders / Diseases
    for SLCO4A1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLCO4A1 for disorders           About GeneDecksing

    OMIM gene information: 612436    OMIM disorders: --

    11 diseases for SLCO4A1:    About MalaCards
    allan-herndon-dudley syndrome    aneurysmal bone cysts    mucinous cystadenocarcinoma    thyroid hormone metabolism
    cystadenocarcinoma    inflammatory bowel disease    cholestasis    ovarian cancer
    thyroiditis    osteosarcoma    cerebritis

    1 disease from the University of Copenhagen DISEASES database for SLCO4A1:
    Cholestasis
    Human Genome Epidemiology (HuGE) Navigator: SLCO4A1 (2 documents)

    Export disorders for SLCO4A1 gene to outside databases

    Publications
    for SLCO4A1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLCO4A1 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with SLCO4A1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (PubMed id 10873595)1, 2, 3, 7 Tamai I.... Tsuji A. (2000)
    2. Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. (PubMed id 11316767)1, 2, 7, 9 Fujiwara K.... Abe T. (2001)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodiff erentiation. (PubMed id 21486766)1 Chan S.Y....Kilby M.D. (2011)
    9. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)

    External Searches for SLCO4A1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing SLCO4A1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28231 HGNC: 10953 AceView: SLCO4A1 Ensembl:ENSG00000101187 euGenes: HUgn28231
    ECgene: SLCO4A1 H-InvDB: SLCO4A1

    Other Databases showing SLCO4A1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLCO4A1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLCO4A1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLCO4A1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLCO4A1 gene:
    Search GeneIP for patents involving SLCO4A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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