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SLCO4A1 Gene

protein-coding   GIFtS: 63
GCID: GC20P061273

Solute Carrier Organic Anion Transporter Family, Member...

(Previous names: solute carrier family 21 (organic anion transporter), member...)
(Previous symbol: SLC21A12)
  See SLCO4A1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Organic Anion Transporter Family, Member 4A11 2     Solute Carrier Family 21 Member 122 3
SLC21A121 2 3     OATP-E2 3
OATP4A12 3 5     OATP-RP12 3
OATPE2 3 5     OATP12 3
Solute Carrier Family 21 (Organic Anion Transporter), Member 121 2     OATPRP12 3
Colon Organic Anion Transporter2 3     POAT2 3
Organic Anion Transporter Polypeptide-Related Protein 12 3     Organic Anion Transporting Polypeptide E2
Organic Anion-Transporting Polypeptide E2 3     Solute Carrier Organic Anion Transporter Family Member 4A12
Sodium-Independent Organic Anion Transporter E2 3     

External Ids:    HGNC: 109531   Entrez Gene: 282312   Ensembl: ENSG000001011877   OMIM: 6124365   UniProtKB: Q96BD03   

Export aliases for SLCO4A1 gene to outside databases

Previous GC identifers: GC20P062000 GC20P060744 GC20P057991


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLCO4A1 Gene:
SLCO4A1 (solute carrier organic anion transporter family, member 4A1) is a protein-coding gene. Diseases associated with SLCO4A1 include aneurysmal bone cysts, and mucinous cystadenocarcinoma. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLCO2A1.

UniProtKB/Swiss-Prot: SO4A1_HUMAN, Q96BD0
Function: Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3
(triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate

Gene Wiki entry for SLCO4A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLCO4A1 gene promoter:
         AhR   p53   Tal-1beta   E47   Arnt   HNF-1A   HNF-1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLCO4A1 promoter sequence
   Search Chromatin IP Primers for SLCO4A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLCO4A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.1

SLCO4A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO4A1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P061273:  view genomic region     (about GC identifiers)

Start:
61,273,797 bp from pter      End:
61,317,137 bp from pter
Size:
43,341 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SO4A1_HUMAN, Q96BD0 (See protein sequence)
Recommended Name: Solute carrier organic anion transporter family member 4A1  
Size: 722 amino acids; 77193 Da
Sequence caution: Sequence=BAA91247.1; Type=Erroneous initiation;
Secondary accessions: Q9H4T7 Q9H4T8 Q9H8P2 Q9NWX8 Q9UI35 Q9UIG7
Alternative splicing: 4 isoforms:  Q96BD0-1   Q96BD0-2   Q96BD0-3   Q96BD0-4   

Explore the universe of human proteins at neXtProt for SLCO4A1: NX_Q96BD0

Explore proteomics data for SLCO4A1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys66, Lys353
  • Glycosylation2 at Asn499, Asn557
  • Modification sites at PhosphoSitePlus

  • See SLCO4A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057438.3  
    ENSEMBL proteins: 
     ENSP00000434245   ENSP00000359538   ENSP00000414855   ENSP00000217159  
    Reactome Protein details: Q96BD0

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: OATP4A1
    SLCO family of organic anion transporting polypeptides

    4 InterPro protein domains:
     IPR002350 Kazal_dom
     IPR004156 OA_transporter
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q96BD0

    ProtoNet protein and cluster: Q96BD0

    2 Blocks protein domains:
    IPB004156 Organic anion transporter polypeptide (OATP)
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: SO4A1_HUMAN, Q96BD0
    Similarity: Belongs to the organo anion transporter (TC 2.A.60) family
    Similarity: Contains 1 Kazal-like domain


    Find genes that share domains with SLCO4A1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SO4A1_HUMAN, Q96BD0
    Function: Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3
    (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SLCO4A1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLCO4A1:
     Increased HPV18 LCR reporter a 

    Animal Models:
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    hsa-mir-92b-3p (MIRT040640), hsa-mir-335-5p (MIRT017470), hsa-let-7e-5p (MIRT051635)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SO4A1_HUMAN, Q96BD0: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol2
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLCO4A1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLCO4A1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transmembrane transport of small molecules0.47
    2Transport of vitamins, nucleosides, and related molecules
    Transport of organic anions0.00
    Transport of vitamins, nucleosides, and related molecules
    3Hepatic ABC Transporters
    Hepatic ABC Transporters0.41


    Find genes that share SuperPaths with SLCO4A1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SLCO4A1
        Hepatic ABC Transporters

    1 Reactome Pathway for SLCO4A1
        Transport of organic anions


        Pathway & Disease-focused RT2 Profiler PCR Array including SLCO4A1: 
              Drug Transporters in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLCO4A1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for SLCO4A1 (Q96BD03 ENSP000002171594) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631043I2D: score=3 
    MTMR9Q96QG73I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0043252sodium-independent organic anion transport TAS--
    GO:0055085transmembrane transport TAS--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLCO4A1 (SO4A1)

    Selected HMDB Compounds for SLCO4A1 (see all 86)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acidChenodeoxycholic acid 3-glucuronide (see all 3)58814-71-4--
    1,3,12-Trihydroxycholan-24-oic acid1,3,12-Trihydroxycholan-24-oate (see all 6)63266-91-1--
    1,3,7,12-Tetrahydroxycholan-24-oic acid1,3,7,12-Tetrahydroxycholan-24-oate (see all 10)63266-89-7--
    12-Ketodeoxycholic acid12-Dehydrodeoxycholate (see all 20)5130-29-0--
    12a-Hydroxy-3-oxocholadienic acid12a-Hydroxy-3-oxo-4,6-choladien-24-oate (see all 8)13535-96-1--
    12b-Hydroxy-5b-cholanoic acid12b-Hydroxy-5b-cholanic acid (see all 9)15173-23-6--
    1b,3a,12a-Trihydroxy-5b-cholanoic acid1,3,12-trihydroxy-(5b)-Cholan-24-oate (see all 6)80434-32-8--
    1b,3a,7a-Trihydroxy-5b-cholanoic acid1 beta,3a,7a-Trihydroxy-5b-cholanoate (see all 18)99598-04-6--
    1b-Hydroxycholic acid1b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 5)80875-94-1--
    2b,3a,7a,12a-Tetrahydroxy-5b-cholanoic acid2b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 7)60696-60-8--

    10 DrugBank Compounds for SLCO4A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    LiothyronineL-Liothyronine (see all 5)6893-02-3transportersubstrate inhibitor11316767 14993604
    Liotrix-- 8065-29-0transportersubstrate inhibitor11316767 14993604
    Conjugated EstrogensEstrogens (see all 10)438-67-5transportersubstrate10873595
    Dextrothyroxine-- 51-49-0transporter--11316767
    Digoxin-- 20830-75-5transportersubstrate14993604
    DinoprostoneDinoprostone Prostaglandin E2 (see all 3)363-24-6transportersubstrate10873595
    Estradiol17beta oestradiol (see all 7)50-28-2transporter--10873595
    Levothyroxine(-)-Thyroxine (see all 13)51-48-9transporter--11316767
    Penicillin G-- 61-33-6transportersubstrate10873595
    Taurocholic Acid-- 81-24-3transporterinhibitor11316767

    1 IUPHAR Ligand for SLCO4A1 (OATP4A1)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]estrone-3-sulphate
    NoneNone--

    2 Novoseek inferred chemical compound relationships for SLCO4A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oatp 90.7 14 11316767 (4), 12542534 (2), 19885603 (1)
    taurocholate 67.9 1 16637898 (1)



    Find genes that share compounds with SLCO4A1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLCO4A1 gene: 
    NM_016354.3  

    Unigene Cluster for SLCO4A1:

    Solute carrier organic anion transporter family, member 4A1
    Hs.235782  [show with all ESTs]
    Unigene Representative Sequence: NM_016354
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497209 ENST00000370507 ENST00000470412 ENST00000495889 ENST00000466961
    ENST00000451793 ENST00000497919 ENST00000466818 ENST00000217159(uc002ydb.1 uc002yde.1)

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    Additional mRNA sequence: 

    AB031051.1 AF187817.1 AF205072.1 AK000551.1 AK023410.1 BC015727.1 

    12 DOTS entries:

    DT.212594  DT.100743380  DT.95102841  DT.95148575  DT.100840473  DT.101975909  DT.95102799  DT.100744646 
    DT.101977556  DT.92428716  DT.97858867  DT.97765643 

    Selected AceView cDNA sequences (see all 138):

    BX645582 BU196388 BQ948972 AB031051 BE251142 BU543537 BP360141 AF187817 
    CR616855 NM_016354 CR607274 BU502596 BX105765 F29712 BM703715 BQ924684 
    BX340091 BU543183 BX483888 BU543102 BM757403 AI027850 BE501491 BF038849 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLCO4A1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
    SP1:                                -     -                                         -                 -     -                     
    SP2:                                      -     -     -           -     -           -                 -     -     -     -         
    SP3:                                                                                                                              
    SP4:                                                              -     -     -     -                 -     -                     
    SP5:                                                                                -                                             


    ECgene alternative splicing isoforms for SLCO4A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLCO4A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCTCCTGT
    SLCO4A1 Expression
    About this image


    SLCO4A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    SLCO4A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLCO4A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.235782

    UniProtKB/Swiss-Prot: SO4A1_HUMAN, Q96BD0
    Tissue specificity: Ubiquitous, with the exception of spleen and leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including SLCO4A1: 
              Drug Transporters in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLCO4A1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slco4a11 , 5 solute carrier organic anion transporter family, member more1, 5 79.66(n)1
    76.72(a)1
      2 (102.99 cM)5
    1081151  NM_148933.11  NP_683735.11 
     1804562455 
    chicken
    (Gallus gallus)
    Aves SLCO4A11 solute carrier organic anion transporter family, member more 70.18(n)
    70.91(a)
      419231  NM_001278151.1  NP_001265080.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLCO4A16
    solute carrier organic anion transporter family, m...
    65(a)
    1 ↔ 1
    4(152000913-152077803)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slco4a11 solute carrier organic anion transporter family, member more 66.12(n)
    66.28(a)
      100145193  NM_001126683.1  NP_001120155.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slco4a11 solute carrier organic anion transporter family, member more 64.76(n)
    65.28(a)
      567865  XM_691171.3  XP_696263.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Oatp26F1 Organic anion transporting polypeptide 26F 56.11(n)
    46.12(a)
      33927  NM_135211.3  NP_609055.2 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y70G10A.31 CELE_Y70G10A.3 46.75(n)
    37.95(a)
      190573  NM_066866.1  NP_499267.1 


    ENSEMBL Gene Tree for SLCO4A1 (if available)
    TreeFam Gene Tree for SLCO4A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLCO4A1 gene
    SLCO2A12  SLCO4C12  SLCO1B72  ENSG000002570622  SLCO1B32  SLCO3A12  SLCO2B12  SLCO5A12  
    SLCO1B12  SLCO6A12  SLCO1A22  ENSG000002570462  SLCO1C12  
    13 SIMAP similar genes for SLCO4A1 using alignment to 2 protein entries:     SO4A1_HUMAN (see all proteins):
    SLCO4C1    SLCO2A1    SLCO1B3    SLCO6A1    LST3    SLC21A8
    SLCO2B1    SLCO5A1    SLCO1B1    SLCO1A2    SLCO1B7    SLCO1C1
    SLCO3A1

    Find genes that share paralogs with SLCO4A1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLCO4A1 (see all 658)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs783510591,2
    --61277276(+) GTGTCA/GTCCAG 1 -- int10--------
    rs126260981,2
    C,F,H--61277335(+) CTTTCG/AGGAGG 1 -- int12Minor allele frequency- A:0.29NA EA 124
    rs1118167301,2
    C,F--61277460(+) CAAGCC/TCCCCG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1472423901,2
    C--61277497(+) CACACA/GTTGGG 1 -- int10--------
    rs1407455561,2
    --61277565(+) CCACCC/TGCCCT 1 -- int10--------
    rs1160152761,2
    C,F--61277650(+) AGGAGT/CCCCAG 1 -- int11Minor allele frequency- C:0.09WA 118
    rs1423188741,2
    --61277689(+) GGAAGC/TAGGCC 1 -- int10--------
    rs1136322261,2
    C--61277916(+) GAGGCTGA/-GGAGG 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs562004231,2
    C,F--61277969(+) GGGCTC/TCGGGG 1 -- int13Minor allele frequency- T:0.08WA NA 240
    rs1508428061,2
    --61277974(+) CCGGGA/GCCGGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for SLCO4A1 (61273797 - 61317137 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLCO4A1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv994234CNV Deletion20482838
    esv1387013CNV Deletion17803354
    esv2722821CNV Deletion23290073
    esv2722820CNV Deletion23290073
    esv2422398CNV Duplication17116639
    nsv428380CNV Loss18775914
    nsv913073CNV Loss21882294
    nsv913106CNV Loss21882294
    nsv834026CNV Loss17160897
    dgv4603n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLCO4A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLCO4A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612436    OMIM disorders: --

    2 diseases for SLCO4A1:    
    About MalaCards
    aneurysmal bone cysts    mucinous cystadenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for SLCO4A1:
    Cholestasis

    Find genes that share disorders with SLCO4A1           About GenesLikeMe

    Genetic Association Database (GAD): SLCO4A1
    Human Genome Epidemiology (HuGE) Navigator: SLCO4A1 (2 documents)

    Export disorders for SLCO4A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLCO4A1 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with SLCO4A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (PubMed id 10873595)1, 2, 3, 7 Tamai I.... Tsuji A. (Biochem. Biophys. Res. Commun. 2000)
    2. Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. (PubMed id 11316767)1, 2, 7, 9 Fujiwara K.... Abe T. (Endocrinology 2001)
    3. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation. (PubMed id 21486766)1 Chan S.Y....Kilby M.D. (J. Physiol. (Lond.) 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 28231 HGNC: 10953 AceView: SLCO4A1 Ensembl:ENSG00000101187 euGenes: HUgn28231
    ECgene: SLCO4A1 H-InvDB: SLCO4A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLCO4A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLCO4A1 gene:
    Search GeneIP for patents involving SLCO4A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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