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SLCO3A1 Gene

protein-coding   GIFtS: 59
GCID: GC15P092396

Solute Carrier Organic Anion Transporter Family, Member...

(Previous names: solute carrier family 21 (organic anion transporter), member...)
(Previous symbol: SLC21A11)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Organic Anion Transporter Family, Member 3A11 2     Sodium-Independent Organic Anion Transporter D2 3
SLC21A111 2 3     Solute Carrier Family 21 Member 112 3
OATP3A12 3 5     OATP-D2 3
OATPD2 3 5     OATP-RP32 3
Solute Carrier Family 21 (Organic Anion Transporter), Member 111 2     OATPRP32 3
Organic Anion Transporter Polypeptide-Related Protein 32 3     PGE1 Transporter2 3
Organic Anion-Transporting Polypeptide D2 3     Solute Carrier Organic Anion Transporter Family Member 3A12

External Ids:    HGNC: 109521   Entrez Gene: 282322   Ensembl: ENSG000001764637   OMIM: 6124355   UniProtKB: Q9UIG83   

Export aliases for SLCO3A1 gene to outside databases

Previous GC identifers: GC15P090126 GC15P090197 GC15P068535


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLCO3A1 Gene:
SLCO3A1 (solute carrier organic anion transporter family, member 3A1) is a protein-coding gene. Diseases associated with SLCO3A1 include aneurysmal bone cysts, and nicotine dependence. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLCO2A1.

UniProtKB/Swiss-Prot: SO3A1_HUMAN, Q9UIG8
Function: Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595).
Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but
not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate,
digoxin nor DHEAS (PubMed:16971491)

Gene Wiki entry for SLCO3A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLCO3A1 gene promoter:
         RP58   POU3F2 (N-Oct-5a)   NF-AT   RORalpha1   NF-AT4   S8   NF-AT2   NF-AT3   SEF-1 (1)   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLCO3A1 promoter sequence
   Search Chromatin IP Primers for SLCO3A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLCO3A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26

SLCO3A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO3A1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P092396:  view genomic region     (about GC identifiers)

Start:
92,396,925 bp from pter      End:
92,715,665 bp from pter
Size:
318,741 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SO3A1_HUMAN, Q9UIG8 (See protein sequence)
Recommended Name: Solute carrier organic anion transporter family member 3A1  
Size: 710 amino acids; 76553 Da
Secondary accessions: A8K4A7 B3KPY5 B3KUR7 C6G486 Q9BW73 Q9GZV2
Alternative splicing: 4 isoforms:  Q9UIG8-1   Q9UIG8-2   Q9UIG8-3   Q9UIG8-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLCO3A1: NX_Q9UIG8

Explore proteomics data for SLCO3A1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn153, Asn169, Asn381, Asn457, Asn502, Asn505, Asn519
  • Modification sites at PhosphoSitePlus

  • See SLCO3A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138516.1  NP_037404.2  

    ENSEMBL proteins: 
     ENSP00000320634   ENSP00000387846   ENSP00000450559   ENSP00000451287   ENSP00000451780  
    Reactome Protein details: Q9UIG8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: OATP3A1
    SLCO family of organic anion transporting polypeptides

    3 InterPro protein domains:
     IPR002350 Kazal_dom
     IPR004156 OA_transporter
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9UIG8

    ProtoNet protein and cluster: Q9UIG8

    2 Blocks protein domains:
    IPB004156 Organic anion transporter polypeptide (OATP)
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: SO3A1_HUMAN, Q9UIG8
    Similarity: Belongs to the organo anion transporter (TC 2.A.60) family
    Similarity: Contains 1 Kazal-like domain


    SLCO3A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SO3A1_HUMAN, Q9UIG8
    Function: Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595).
    Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but
    not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate,
    digoxin nor DHEAS (PubMed:16971491)
    Biophysicochemical properties: Kinetic parameters: KM=101 nM for PGE1 (isoform 1); KM=218 nM for PGE1 (isoform 2);
    KM=219 nM for PGE2 (isoform 1); KM=371 nM for PGE2 (isoform 2);

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005515protein binding ----
         
    SLCO3A1 for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target SLCO3A1:
    hsa-mir-215-5p (MIRT024914), hsa-mir-192-5p (MIRT026667), hsa-mir-218-1-3p (MIRT038665), hsa-let-7e-5p (MIRT051495)

    Block miRNA regulation of human, mouse, rat SLCO3A1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLCO3A1 (see all 83):
    hsa-miR-3152-3p hsa-miR-520f hsa-miR-188-5p hsa-miR-146a hsa-miR-128 hsa-miR-3921 hsa-miR-3916 hsa-miR-637
    SwitchGear 3'UTR luciferase reporter plasmidSLCO3A1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SO3A1_HUMAN, Q9UIG8: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    SLCO3A1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLCO3A1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transmembrane transport of small molecules0.47
    2Transport of vitamins, nucleosides, and related molecules
    Transport of organic anions0.00
    Transport of vitamins, nucleosides, and related molecules

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLCO3A1
        Transport of organic anions



    SLCO3A1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SLCO3A1: 
              Drug Transporters in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLCO3A1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SLCO3A1 (Q9UIG83 ENSP000003206344) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A3R1O147453, ENSP000002626134I2D: score=1 STRING: ENSP00000262613
    SLC9A3R2Q155993, ENSP000004080054I2D: score=1 STRING: ENSP00000408005
    PDZD3ENSP000003271074STRING: ENSP00000327107
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0043252sodium-independent organic anion transport TAS--
    GO:0055085transmembrane transport TAS--

    SLCO3A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLCO3A1 (SO3A1)

    9 DrugBank Compounds for SLCO3A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DinoprostoneDinoprostone Prostaglandin E2 (see all 3)363-24-6transportersubstrate10873595 14631946
    Alprostadil-- 745-65-3transporterinhibitor14631946
    AminohippurateAminohippurate Sodium (see all 7)94-16-6transporterinhibitor14631946
    Conjugated EstrogensEstrogens (see all 10)438-67-5transportersubstrate10873595
    Dinoprost TromethamineDinoprost, trometamol salt (see all 7)38562-01-5transporter--14631946
    Iloprost-- 78919-13-8transportersubstrate14631946
    MethotrexateAmethopterin (see all 12)59-05-2transportersubstrate14631946
    Penicillin G-- 61-33-6transportersubstrate10873595
    Taurocholic Acid-- 81-24-3transporterinhibitor14631946

    2 IUPHAR Ligands for SLCO3A1 (OATP3A1)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]estrone-3-sulphate
    NoneNone--
    [3H]PGE2
    NoneNone--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLCO3A1 gene (2 alternative transcripts): 
    NM_001145044.1  NM_013272.3  

    Unigene Cluster for SLCO3A1:

    Solute carrier organic anion transporter family, member 3A1
    Hs.311187  [show with all ESTs]
    Unigene Representative Sequence: NM_013272
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318445(uc002bqx.2) ENST00000553653 ENST00000424469(uc002bqy.2 uc002bqz.1)
    ENST00000555111 ENST00000553304 ENST00000555769(uc010boc.1) ENST00000556649
    ENST00000555549 ENST00000555892 ENST00000555210 ENST00000555513 ENST00000564072
    ENST00000566477
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    Additional mRNA sequence: 

    AB031050.2 AF187816.1 AF205074.1 AK057031.1 AK097797.1 AK124270.1 AK290872.1 AK308463.1 
    AK310306.1 AL109695.1 BC000585.2 

    8 DOTS entries:

    DT.113311  DT.95166764  DT.100785589  DT.455767  DT.100036627  DT.40108526  DT.40267114  DT.91947139 

    Selected AceView cDNA sequences (see all 212):

    BE467492 BU163383 AI359612 BQ877250 BQ675933 BE671835 AA775372 AL109695 
    AI421413 AA984473 BM697511 BM974617 BQ066581 BF058428 AI824343 AI633367 
    AW003026 AI081321 F13203 AI694530 AA912412 BM750662 AA770128 AK097797 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLCO3A1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
    SP1:                          -                                   -                                         -                     
    SP2:        -     -     -     -     -                             -                                         -                     
    SP3:                                                                                                        -                     
    SP4:                                -                             -                                                               
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for SLCO3A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLCO3A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTTCAGGA
    SLCO3A1 Expression
    About this image


    SLCO3A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
             Retina
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
     
     Kidney (Urinary System)
             Renal Collecting Duct System
     
     Gonad
             XY Germ Cells Testis Cord
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
    SLCO3A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLCO3A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.311187

    UniProtKB/Swiss-Prot: SO3A1_HUMAN, Q9UIG8
    Tissue specificity: Ubiquitous. Highly expressed in spleen and leukocytes. Generally the expression of isoform 1
    is higher than that of isoform 2. Isoform 2 is particularly abundant in testis and brain. In testis, isoform 1 is
    detected in spermatogonia at different stages and absent from Sertoli cells, while isoform 2 is present in both
    (at protein level). Expressed in the choroid plexus epithelium, isoform 1 being localized at the basolateral
    membrane and isoform 2 at the apical one, as well as in the subapical intracellular vesicular compartments.
    Differential expression of both isoforms is also observed in other brain region: isoform 1 is very abundant in
    the gray matter of the frontal cortex, but is not associated with neuronal cell bodies. Not detected in the white
    matter. In contrast, isoform 2 is associated with neuronal bodies and axons in both the gray and the white
    matters of the frontal cortex

        Pathway & Disease-focused RT2 Profiler PCR Array including SLCO3A1: 
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO3A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLCO3A1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slco3a11 , 5 solute carrier organic anion transporter family, member more1, 5 91.03(n)1
    97.89(a)1
      7 (42.95 cM)5
    1081161  NM_023908.21  NP_076397.21 
     742754195 
    chicken
    (Gallus gallus)
    Aves SLCO3A11 solute carrier organic anion transporter family, member more 83.62(n)
    92.8(a)
      415504  XM_413876.4  XP_413876.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLCO3A16
    solute carrier organic anion transporter family, m...
    90(a)
    1 ↔ 1
    GL343392.1(638245-719118)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slco3a11 solute carrier organic anion transporter family, member more 76.8(n)
    88.42(a)
      100498508  XM_002933314.2  XP_002933360.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slco3a11 solute carrier organic anion transporter family, member more 73.14(n)
    80.27(a)
      569735  NM_001045188.2  NP_001038653.1 


    ENSEMBL Gene Tree for SLCO3A1 (if available)
    TreeFam Gene Tree for SLCO3A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLCO3A1 gene
    SLCO2A12  SLCO4C12  SLCO1B72  ENSG000002570622  SLCO1B32  SLCO2B12  SLCO5A12  SLCO1B12  
    SLCO6A12  SLCO1A22  ENSG000002570462  SLCO4A12  SLCO1C12  
    14 SIMAP similar genes for SLCO3A1 using alignment to 4 protein entries:     SO3A1_HUMAN (see all proteins):
    SLCO1A2    SLCO1B1    SLCO2B1    SLCO1B3    SLCO1B7    DKFZp313M176
    SLCO5A1    SLC21A8    SLCO1C1    LST3    SLCO4C1    SLCO2A1
    SLCO4A1    SLCO6A1

    SLCO3A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLCO3A1 (see all 7858)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1481219381,2
    --92395061(+) AGCACA/TCAGTA 2 -- us2k10--------
    rs285349231,2
    C,F--92395158(+) CATTCA/GTAGAC 2 -- us2k112Minor allele frequency- G:0.48NA NS WA CSA 262
    rs1418794181,2
    --92395192(+) TTACCA/GTCACA 2 -- us2k10--------
    rs118581201,2
    C,F,A,H--92395263(+) CATGAA/TGCAAA 2 -- us2k117Minor allele frequency- T:0.37NS EA NA WA CSA 799
    rs1506335521,2
    --92395265(+) TGAAGC/GAAAGT 2 -- us2k10--------
    rs1387296071,2
    --92395352(+) AAGAAA/GGGGGC 2 -- us2k10--------
    rs118581571,2
    C,F,A,H--92395398(+) GTGTGA/GCCACT 2 -- us2k114Minor allele frequency- G:0.28NS EA NA WA CSA 673
    rs1419132371,2
    C--92395439(+) CTTCAA/GGTGTG 2 -- us2k10--------
    rs1462739601,2
    --92395450(+) GGGGGA/TGCCAA 2 -- us2k10--------
    rs1856324171,2
    --92395524(+) ATCACA/GTCTGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLCO3A1 (92396925 - 92646925 bp, first 250kb of SLCO3A1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLCO3A1 (see all 35):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821516CNV Deletion20802225
    esv2662695CNV Deletion23128226
    esv2663236CNV Deletion23128226
    esv2750035CNV Deletion23290073
    esv2750036CNV Deletion23290073
    esv2750037CNV Deletion23290073
    dgv55e180CNV Deletion20482838
    esv2677093CNV Deletion23128226
    esv2657610CNV Deletion23128226
    esv2661054CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLCO3A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLCO3A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612435    OMIM disorders: --

    13 diseases for SLCO3A1:    
    About MalaCards
    aneurysmal bone cysts    nicotine dependence    attention deficit hyperactivity disorder    choroiditis
    osteosarcoma    lymphoblastic leukemia    hypertension    cerebritis
    schizophrenia    obesity    thyroiditis    leukemia
    neuronitis


    SLCO3A1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLCO3A1
    Human Genome Epidemiology (HuGE) Navigator: SLCO3A1 (5 documents)

    Export disorders for SLCO3A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLCO3A1 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with SLCO3A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (PubMed id 10873595)1, 2, 7 Tamai I.... Tsuji A. (Biochem. Biophys. Res. Commun. 2000)
    2. Molecular characterization of human and rat organic anion transporter OATP-D. (PubMed id 14631946)1, 7, 9 Adachi H....Abe T. (Am. J. Physiol. Renal Physiol. 2003)
    3. Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. (PubMed id 22076464)1, 4 Ellinghaus E....Franke A. (Leukemia 2012)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans. (PubMed id 19330903)1, 4 Montasser M.E....Hixson J.E. (J. Hypertens. 2009)
    6. Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia. (PubMed id 18521091)1, 4 Volpi S....Lavedan C. (Mol. Psychiatry 2009)
    7. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PubMed id 18821565)1, 4 Lasky-Su J....Faraone S.V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    8. Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain. (PubMed id 16971491)1, 2 Huber R.D.... Stieger B. (Am. J. Physiol. 2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 28232 HGNC: 10952 AceView: SLCO3A1 Ensembl:ENSG00000176463 euGenes: HUgn28232
    ECgene: SLCO3A1 H-InvDB: SLCO3A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLCO3A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLCO3A1 gene:
    Search GeneIP for patents involving SLCO3A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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