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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLCO3A1 Gene

protein-coding   GIFtS: 55
GCID: GC15P092396

solute carrier organic anion transporter family, member...

(Previous names: solute carrier family 21 (organic anion transporter), member...)
(Previous symbol: SLC21A11)
 Explore 9 diseases affiliated with
SLCO3A1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLCO3A1    

Aliases
for SLCO3A1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Organic Anion Transporter Family, Member 3A11 2     Organic Anion-Transporting Polypeptide D2 3
OATP3A11 2 3 5     Sodium-Independent Organic Anion Transporter D2 3
OATP-D1 2 3     Solute Carrier Family 21 Member 112 3
SLC21A111 2 3     OATP-RP32 3
OATPD2 3 5     OATPRP32 3
Solute Carrier Family 21 (Organic Anion Transporter), Member 111 2     PGE1 Transporter2 3
Organic Anion Transporter Polypeptide-Related Protein 32 3     Solute Carrier Organic Anion Transporter Family Member 3A12

External Ids:    HGNC: 109521   Entrez Gene: 282322   Ensembl: ENSG000001764637   OMIM: 6124355   UniProtKB: Q9UIG83   

Export aliases for SLCO3A1 gene to outside databases

Previous GC identifers: GC15P090126 GC15P090197 GC15P068535


Summaries
for SLCO3A1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SO3A1_HUMAN, Q9UIG8
Function: Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595).
Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not
DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin
nor DHEAS (PubMed:16971491)

Gene Wiki entry for SLCO3A1


Genomic Views
for SLCO3A1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010274.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLCO3A1 gene promoter:
         RP58   POU3F2 (N-Oct-5a)   NF-AT   RORalpha1   NF-AT4   S8   NF-AT2   NF-AT3   SEF-1 (1)   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLCO3A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLCO3A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLCO3A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26

SLCO3A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO3A1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P092396:  view genomic region     (about GC identifiers)

Start:
 92,396,925 bp from pter      End:
 92,715,665 bp from pter
Size:
 318,741 bases      Orientation:
 plus strand

Proteins
for SLCO3A1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SO3A1_HUMAN, Q9UIG8 (See protein sequence)
Recommended Name: Solute carrier organic anion transporter family member 3A1  
Size: 710 amino acids; 76553 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A8K4A7 B3KPY5 B3KUR7 C6G486 Q9BW73 Q9GZV2
Alternative splicing: 4 isoforms:  Q9UIG8-1   Q9UIG8-2   Q9UIG8-3   Q9UIG8-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLCO3A1: NX_Q9UIG8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UIG8

    • SLCO3A1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138516.1  NP_037404.2  

    ENSEMBL proteins: 
     ENSP00000320634   ENSP00000387846   ENSP00000450559   ENSP00000451755   ENSP00000450516  
     ENSP00000451287   ENSP00000451780  
    Reactome Protein details: Q9UIG8
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    Uscn Proteins for SLCO3A1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--


    SLCO3A1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLCO3A1

    Protein Domains /
    Families
    for SLCO3A1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLCO3A1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR002350 Prot_inh_Kazal
     IPR004156 OA_transporter
     IPR011497 Kazal-type_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9UIG8

    ProtoNet protein and cluster: Q9UIG8

    2 Blocks protein families:
    IPB004156 Organic anion transporter polypeptide (OATP)
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: SO3A1_HUMAN, Q9UIG8
    Similarity: Belongs to the organo anion transporter (TC 2.A.60) family
    Similarity: Contains 1 Kazal-like domain


    Function
    for SLCO3A1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SO3A1_HUMAN, Q9UIG8
    Function: Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595).
    Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not
    DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin
    nor DHEAS (PubMed:16971491)
    Biophysicochemical properties: Kinetic parameters: KM=101 nM for PGE1 (isoform 1); KM=218 nM for PGE1 (isoform 2);
    KM=219 nM for PGE2 (isoform 1); KM=371 nM for PGE2 (isoform 2);

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    hsa-miR-3152-3p hsa-miR-520f hsa-miR-188-5p hsa-miR-146a hsa-miR-128 hsa-miR-3921 hsa-miR-3916 hsa-miR-637
    SwitchGear 3'UTR luciferase reporter plasmid: SLCO3A1 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--


    SLCO3A1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for SLCO3A1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transport of organic anions
    		Transport of organic anions1.00
    		Transport of vitamins, nucleosides, and related molecules0.35
    2SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for SLCO3A1
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of vitamins, nucleosides, and related molecules
    Transport of organic anions



    SLCO3A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLCO3A1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SLCO3A1 (Q9UIG83 ENSP000003206344) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A3R1O147453, ENSP000002626134I2D: score=1 STRING: ENSP00000262613
    SLC9A3R2Q155993, ENSP000004080054I2D: score=1 STRING: ENSP00000408005
    PDZD3ENSP000003271074STRING: ENSP00000327107
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043252sodium-independent organic anion transport TAS--
    GO:0055085transmembrane transport TAS--


    SLCO3A1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLCO3A1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLCO3A1

    8 DrugBank Compounds for SLCO3A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alprostadil-- 745-65-3transporterinhibitor14631946
    AminohippurateAminohippurate Sodium (see all 7)94-16-6transporterinhibitor14631946
    Conjugated EstrogensEstrogens (see all 10)438-67-5transportersubstrate10873595
    DinoprostoneDinoprostone Prostaglandin E2 (see all 3)363-24-6transportersubstrate10873595
    Iloprost-- 78919-13-8transportersubstrate14631946
    MethotrexateAmethopterin (see all 12)59-05-2transportersubstrate14631946
    Penicillin G-- 61-33-6transportersubstrate10873595
    Taurocholic Acid-- 81-24-3transporterinhibitor14631946

    Search CenterWatch for drugs/clinical trials and news about SLCO3A1 / SO3A1 

    Transcripts
    for SLCO3A1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLCO3A1 gene (2 alternative transcripts): 
    NM_001145044.1  NM_013272.3  

    Unigene Cluster for SLCO3A1:

    Solute carrier organic anion transporter family, member 3A1
    Hs.311187  [show with all ESTs]
    Unigene Representative Sequence: NM_013272
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318445(uc002bqx.2) ENST00000553653 ENST00000424469(uc002bqy.2 uc002bqz.1)
    ENST00000555111 ENST00000553304 ENST00000555769(uc010boc.1) ENST00000556649
    ENST00000555549 ENST00000555892 ENST00000555210 ENST00000555439 ENST00000555513
    ENST00000564072 ENST00000566477

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    8/83 QIAGEN miScript miRNA Assays for microRNAs that regulate SLCO3A1 (see all 83):
    hsa-miR-3152-3p hsa-miR-520f hsa-miR-188-5p hsa-miR-146a hsa-miR-128 hsa-miR-3921 hsa-miR-3916 hsa-miR-637
    SwitchGear 3'UTR luciferase reporter plasmid: SLCO3A1 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB031050.2 AF187816.1 AF205074.1 AK057031.1 AK097797.1 AK124270.1 AK290872.1 AK308463.1 
    AK310306.1 AL109695.1 BC000585.2 

    8 DOTS entries:

    DT.113311  DT.95166764  DT.100785589  DT.455767  DT.100036627  DT.40108526  DT.40267114  DT.91947139 

    24/212 AceView cDNA sequences (see all 212):

    BE467492 BU163383 AI359612 AA775372 AL109695 BE671835 BQ675933 BQ066581 
    BM974617 BF058428 AA984473 BQ878301 AA826044 BU161162 AI685873 BE217940 
    AI356069 BI335893 AI356797 AW205561 BQ083637 AK097797 BM750662 BE502928 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SLCO3A1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
    SP1:                          -                                   -                                         -                     
    SP2:        -     -     -     -     -                             -                                         -                     
    SP3:                                                                                                        -                     
    SP4:                                -                             -                                                               
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for SLCO3A1

    Expression
    for SLCO3A1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLCO3A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTTTCAGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLCO3A1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    LungTracheaBasal CellsLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLCO3A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLCO3A1

    SOURCE GeneReport for Unigene cluster: Hs.311187

    UniProtKB/Swiss-Prot: SO3A1_HUMAN, Q9UIG8
    Tissue specificity: Ubiquitous. Highly expressed in spleen and leukocytes. Generally the expression of isoform 1 is
    higher than that of isoform 2. Isoform 2 is particularly abundant in testis and brain. In testis, isoform 1 is
    detected in spermatogonia at different stages and absent from Sertoli cells, while isoform 2 is present in both (at
    protein level). Expressed in the choroid plexus epithelium, isoform 1 being localized at the basolateral membrane and
    isoform 2 at the apical one, as well as in the subapical intracellular vesicular compartments. Differential expression
    of both isoforms is also observed in other brain region: isoform 1 is very abundant in the gray matter of the frontal
    cortex, but is not associated with neuronal cell bodies. Not detected in the white matter. In contrast, isoform 2 is
    associated with neuronal bodies and axons in both the gray and the white matters of the frontal cortex

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    In Situ
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    Orthologs
    for SLCO3A1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLCO3A1 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLCO3A11 solute carrier organic anion transporter family, member more 83.59(n)
    92.48(a)    		   415504  XM_413876.3  XP_413876.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SLCO3A16
    		 --
    		 90(a)
    		 1 ↔ 1
    		 GL343392.1(638909-719012)
    zebrafish
    (Danio rerio)    		 Actinopterygii slco3a11 solute carrier organic anion transporter family, member more 72.85(n)
    80.24(a)    		   569735  NM_001045188.2  NP_001038653.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Oatp58Da6
    Oatp33Ea6
    (see all 7)    		 Organic anion transporting polypeptide 33Ea
    (see all 7)    		 23(a)
    22(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 2R(18105961-18108393)
    2L(12441401-12445924)
    worm
    (Caenorhabditis elegans)    		 Secernentea F21G4.16
    F47E1.46
    (see all 4)    		 Protein F47E1.4
    (see all 4)    		 25(a)
    22(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 X(9889257-9892270)
    X(9062779-9066602)


    ENSEMBL Gene Tree for SLCO3A1 (if available)
    TreeFam Gene Tree for SLCO3A1 (if available) 

    Paralogs
    for SLCO3A1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLCO3A1 gene
    SLCO2A12  SLCO4C12  SLCO1B72  ENSG000002570622  SLCO1B32  SLCO5A12  SLCO2B12  SLCO6A12  
    SLCO1B12  ENSG000002570462  SLCO4A12  SLCO1A22  SLCO1C12  
    14 SIMAP similar genes for SLCO3A1 using alignment to 5 protein entries:     SO3A1_HUMAN (see all proteins):
    SLCO1A2    SLCO1B3    SLCO1B1    SLCO2B1    SLCO1B7    DKFZp313M176
    SLCO5A1    SLC21A8    SLCO1C1    LST3    SLCO4C1    SLCO2A1
    SLCO4A1    SLCO6A1

    SLCO3A1 for paralogs           About GeneDecksing



    Genomic Variants
    for SLCO3A1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6718 NCBI SNPs in SLCO3A1 are shown (see all 6718)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1481219381,2
    		--92395061(+) AGCACA/TCAGTA 2 -- us2k10--------
    rs285349231,2
    		C,F,--92395158(+) CATTCA/GTAGAC 2 -- us2k112Minor allele frequency- G:0.48NA NS WA CSA 262
    rs1418794181,2
    		--92395192(+) TTACCA/GTCACA 2 -- us2k10--------
    rs118581201,2
    		C,F,A,H,--92395263(+) CATGAA/TGCAAA 2 -- us2k117Minor allele frequency- T:0.37NS EA NA WA CSA 799
    rs1506335521,2
    		--92395265(+) TGAAGC/GAAAGT 2 -- us2k10--------
    rs1387296071,2
    		--92395352(+) AAGAAA/GGGGGC 2 -- us2k10--------
    rs118581571,2
    		C,F,A,H,--92395398(+) GTGTGA/GCCACT 2 -- us2k114Minor allele frequency- G:0.28NS EA NA WA CSA 673
    rs1419132371,2
    		--92395439(+) CTTCAA/GGTGTG 2 -- us2k10--------
    rs1462739601,2
    		--92395450(+) GGGGGA/TGCCAA 2 -- us2k10--------
    rs1856324171,2
    		--92395524(+) ATCACA/GTCTGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLCO3A1 (92396925 - 92646925 bp, first 250kb of SLCO3A1)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 18 variations for SLCO3A1
         13 CNVs: 0463 35352 66874 58742 87840 87842 35353 0462 0461 3095 66876 87841 66875
         5 Indels: 77068 77069 87844 77070 87843

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    Disorders / Diseases
    for SLCO3A1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLCO3A1 for disorders           About GeneDecksing

    OMIM gene information: 612435    OMIM disorders: --

    9 diseases for SLCO3A1:    About MalaCards
    attention deficit hyperactivity disorder    aneurysmal bone cysts    choroiditis    osteosarcoma
    hypertension    cerebritis    schizophrenia    thyroiditis
    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: SLCO3A1 (5 documents)

    Export disorders for SLCO3A1 gene to outside databases

    Publications
    for SLCO3A1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLCO3A1 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with SLCO3A1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (PubMed id 10873595)1, 2, 7 Tamai I.... Tsuji A. (2000)
    2. Molecular characterization of human and rat organic anion transporter OATP-D. (PubMed id 14631946)1, 7, 9 Adachi H....Abe T. (2003)
    3. Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain. (PubMed id 16971491)1, 2 Huber R.D.... Stieger B. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Identification of germline susceptibility loci in ETV6 -RUNX1-rearranged childhood acute lymphoblastic leukemia. (PubMed id 22076464)1 Ellinghaus E....Franke A. (2012)
    7. ANAPC1 and SLCO3A1 are associated with nicotine depend ence: meta-analysis of genome-wide association studies. (PubMed id 22377092)1 Wang K.S....Zeng M. (2012)
    8. The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodiff erentiation. (PubMed id 21486766)1 Chan S.Y....Kilby M.D. (2011)
    9. Expression and localization of the uptake transporter s OATP2B1, OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue. (PubMed id 21278488)1 Kindla J....KAPnig J. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    External Searches for SLCO3A1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing SLCO3A1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28232 HGNC: 10952 AceView: SLCO3A1 Ensembl:ENSG00000176463 euGenes: HUgn28232
    ECgene: SLCO3A1 H-InvDB: SLCO3A1

    Other Databases showing SLCO3A1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLCO3A1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLCO3A1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLCO3A1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLCO3A1 gene:
    Search GeneIP for patents involving SLCO3A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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