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Aliases for SLCO3A1 Gene

Aliases for SLCO3A1 Gene

  • Solute Carrier Organic Anion Transporter Family Member 3A1 2 3 5
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 11 2 3
  • Organic Anion Transporter Polypeptide-Related Protein 3 3 4
  • Sodium-Independent Organic Anion Transporter D 3 4
  • Organic Anion-Transporting Polypeptide D 3 4
  • Solute Carrier Family 21 Member 11 3 4
  • PGE1 Transporter 3 4
  • SLC21A11 3 4
  • OATP-RP3 3 4
  • OATP3A1 3 4
  • OATPRP3 3 4
  • OATP-D 3 4
  • OATPD 3 4
  • Solute Carrier Organic Anion Transporter Family, Member 3A1 2

External Ids for SLCO3A1 Gene

Previous HGNC Symbols for SLCO3A1 Gene

  • SLC21A11

Previous GeneCards Identifiers for SLCO3A1 Gene

  • GC15P090126
  • GC15P090197
  • GC15P092396
  • GC15P068535

Summaries for SLCO3A1 Gene

GeneCards Summary for SLCO3A1 Gene

SLCO3A1 (Solute Carrier Organic Anion Transporter Family Member 3A1) is a Protein Coding gene. Diseases associated with SLCO3A1 include Aneurysmal Bone Cysts. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of vitamins, nucleosides, and related molecules. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLCO1B3.

UniProtKB/Swiss-Prot for SLCO3A1 Gene

  • Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491).

Gene Wiki entry for SLCO3A1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO3A1 Gene

Genomics for SLCO3A1 Gene

Regulatory Elements for SLCO3A1 Gene

Enhancers for SLCO3A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SLCO3A1 on UCSC Golden Path with GeneCards custom track

Promoters for SLCO3A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SLCO3A1 Gene

Chromosome:
15
Start:
91,853,695 bp from pter
End:
92,172,435 bp from pter
Size:
318,741 bases
Orientation:
Plus strand

Genomic View for SLCO3A1 Gene

Genes around SLCO3A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO3A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO3A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO3A1 Gene

Proteins for SLCO3A1 Gene

  • Protein details for SLCO3A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIG8-SO3A1_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 3A1
    Protein Accession:
    Q9UIG8
    Secondary Accessions:
    • A8K4A7
    • B3KPY5
    • B3KUR7
    • C6G486
    • Q9BW73
    • Q9GZV2

    Protein attributes for SLCO3A1 Gene

    Size:
    710 amino acids
    Molecular mass:
    76553 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLCO3A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLCO3A1 Gene

Post-translational modifications for SLCO3A1 Gene

  • Glycosylation at Asn 153, Asn 169, Asn 381, Asn 457, Asn 502, Asn 505, and Asn 519
  • Modification sites at PhosphoSitePlus

Other Protein References for SLCO3A1 Gene

Antibody Products

No data available for DME Specific Peptides for SLCO3A1 Gene

Domains & Families for SLCO3A1 Gene

Gene Families for SLCO3A1 Gene

Suggested Antigen Peptide Sequences for SLCO3A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UIG8

UniProtKB/Swiss-Prot:

SO3A1_HUMAN :
  • Contains 1 Kazal-like domain.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
Domain:
  • Contains 1 Kazal-like domain.
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO3A1: view

Function for SLCO3A1 Gene

Molecular function for SLCO3A1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=101 nM for PGE1 (isoform 1) {ECO:0000269 PubMed:16971491}; KM=218 nM for PGE1 (isoform 2) {ECO:0000269 PubMed:16971491}; KM=219 nM for PGE2 (isoform 1) {ECO:0000269 PubMed:16971491}; KM=371 nM for PGE2 (isoform 2) {ECO:0000269 PubMed:16971491};
UniProtKB/Swiss-Prot Function:
Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491).

Gene Ontology (GO) - Molecular Function for SLCO3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015347 sodium-independent organic anion transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLCO3A1: view
genes like me logo Genes that share phenotypes with SLCO3A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLCO3A1

CRISPR Products

miRNA for SLCO3A1 Gene

miRTarBase miRNAs that target SLCO3A1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLCO3A1 Gene

Localization for SLCO3A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO3A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLCO3A1 Gene COMPARTMENTS Subcellular localization image for SLCO3A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLCO3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with SLCO3A1: view

Pathways & Interactions for SLCO3A1 Gene

genes like me logo Genes that share pathways with SLCO3A1: view

Gene Ontology (GO) - Biological Process for SLCO3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015732 prostaglandin transport IBA --
GO:0043252 sodium-independent organic anion transport TAS --
genes like me logo Genes that share ontologies with SLCO3A1: view

No data available for SIGNOR curated interactions for SLCO3A1 Gene

Drugs & Compounds for SLCO3A1 Gene

(12) Drugs for SLCO3A1 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iloprost Approved, Investigational Pharma Full agonist, Agonist, Transporter, substrate Others, Prostacyclin (PGI2) analog 77
Methotrexate Approved Pharma Transporter, substrate Folate antagonist,inhibits DFHR 1496
Penicillin G Approved, Vet_approved Pharma Transporter, substrate 29
Alprostadil Approved, Investigational Pharma Transporter, inhibitor Prostaglandin. Vasodilator and antiplatelet agent in vivo 69
Aminohippuric acid Approved Pharma Transporter, inhibitor 0
genes like me logo Genes that share compounds with SLCO3A1: view

Transcripts for SLCO3A1 Gene

Unigene Clusters for SLCO3A1 Gene

Solute carrier organic anion transporter family, member 3A1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO3A1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
SP1: - - -
SP2: - - - - - - -
SP3: -
SP4: - -
SP5:
SP6: - - - -
SP7: - -

Relevant External Links for SLCO3A1 Gene

GeneLoc Exon Structure for
SLCO3A1
ECgene alternative splicing isoforms for
SLCO3A1

Expression for SLCO3A1 Gene

mRNA expression in normal human tissues for SLCO3A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO3A1 Gene

This gene is overexpressed in Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for SLCO3A1 Gene

This gene is overexpressed in Spinal cord (47.7) and Peripheral blood mononuclear cells (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLCO3A1 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLCO3A1 Gene:

SLCO3A1

SOURCE GeneReport for Unigene cluster for SLCO3A1 Gene:

Hs.311187

mRNA Expression by UniProt/SwissProt for SLCO3A1 Gene:

Q9UIG8-SO3A1_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in spleen and leukocytes. Generally the expression of isoform 1 is higher than that of isoform 2. Isoform 2 is particularly abundant in testis and brain. In testis, isoform 1 is detected in spermatogonia at different stages and absent from Sertoli cells, while isoform 2 is present in both (at protein level). Expressed in the choroid plexus epithelium, isoform 1 being localized at the basolateral membrane and isoform 2 at the apical one, as well as in the subapical intracellular vesicular compartments. Differential expression of both isoforms is also observed in other brain region: isoform 1 is very abundant in the gray matter of the frontal cortex, but is not associated with neuronal cell bodies. Not detected in the white matter. In contrast, isoform 2 is associated with neuronal bodies and axons in both the gray and the white matters of the frontal cortex.
genes like me logo Genes that share expression patterns with SLCO3A1: view

Primer Products

No data available for Protein tissue co-expression partners for SLCO3A1 Gene

Orthologs for SLCO3A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLCO3A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLCO3A1 34
  • 93.9 (n)
  • 97.18 (a)
SLCO3A1 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLCO3A1 34
  • 94.37 (n)
  • 97.61 (a)
SLCO3A1 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slco3a1 34
  • 91.03 (n)
  • 97.89 (a)
Slco3a1 16
Slco3a1 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLCO3A1 34
  • 99.4 (n)
  • 99.55 (a)
SLCO3A1 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slco3a1 34
  • 90.99 (n)
  • 97.75 (a)
oppossum
(Monodelphis domestica)
Mammalia SLCO3A1 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 92 (a)
OneToMany
-- 35
  • 94 (a)
OneToMany
chicken
(Gallus gallus)
Aves SLCO3A1 34
  • 83.62 (n)
  • 92.8 (a)
SLCO3A1 35
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLCO3A1 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slco3a1 34
  • 76.8 (n)
  • 88.42 (a)
zebrafish
(Danio rerio)
Actinopterygii slco3a1 34
  • 73.14 (n)
  • 80.27 (a)
slco3a1 35
  • 77 (a)
OneToMany
SLCO3A1 (2 of 2) 35
  • 75 (a)
OneToMany
Species where no ortholog for SLCO3A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLCO3A1 Gene

ENSEMBL:
Gene Tree for SLCO3A1 (if available)
TreeFam:
Gene Tree for SLCO3A1 (if available)

Paralogs for SLCO3A1 Gene

genes like me logo Genes that share paralogs with SLCO3A1: view

Variants for SLCO3A1 Gene

Sequence variations from dbSNP and Humsavar for SLCO3A1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1517618 - 92,104,415(-) GCGGG(C/G)TCTGA nc-transcript-variant, reference, missense
rs2677909 -- 92,100,944(+) TATAT(G/T)TCCCC intron-variant
rs2677911 -- 92,106,136(-) AGATT(C/T)CTCAT intron-variant
rs2853650 -- 92,105,976(-) AGAAC(A/G)GGGGG intron-variant
rs2853651 -- 92,103,935(-) GTTTA(C/T)TGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO3A1 Gene

Variant ID Type Subtype PubMed ID
dgv446n67 CNV gain 20364138
dgv4716n54 CNV loss 21841781
dgv4717n54 CNV loss 21841781
dgv4718n54 CNV loss 21841781
dgv4719n54 CNV loss 21841781
dgv4720n54 CNV loss 21841781
dgv4721n54 CNV loss 21841781
dgv4722n54 CNV loss 21841781
dgv4723n54 CNV loss 21841781
dgv4724n54 CNV loss 21841781
dgv4725n54 CNV loss 21841781
dgv4726n54 CNV loss 21841781
dgv55e180 CNV deletion 20482838
esv1040768 CNV insertion 17803354
esv1261605 CNV insertion 17803354
esv1315861 CNV insertion 17803354
esv1359284 CNV insertion 17803354
esv1362653 CNV insertion 17803354
esv23264 CNV gain+loss 19812545
esv25947 CNV loss 19812545
esv2657610 CNV deletion 23128226
esv2661054 CNV deletion 23128226
esv2662695 CNV deletion 23128226
esv2663236 CNV deletion 23128226
esv2677093 CNV deletion 23128226
esv27351 CNV loss 19812545
esv2750034 CNV deletion 23290073
esv2750035 CNV deletion 23290073
esv2750036 CNV deletion 23290073
esv2750037 CNV deletion 23290073
esv2750038 CNV deletion 23290073
esv275567 CNV loss 21479260
esv2760056 CNV loss 17122850
esv3216012 CNV deletion 24192839
esv3305105 CNV mobile element insertion 20981092
esv3309259 CNV mobile element insertion 20981092
esv3344467 CNV insertion 20981092
esv3394291 CNV insertion 20981092
esv3552848 CNV deletion 23714750
esv3552849 CNV deletion 23714750
esv3581821 CNV loss 25503493
esv3581822 CNV loss 25503493
esv3584923 CNV gain 24956385
esv3637251 CNV loss 21293372
esv3637252 CNV loss 21293372
esv3637254 CNV loss 21293372
esv3637255 CNV loss 21293372
esv3637257 CNV loss 21293372
esv3637258 CNV loss 21293372
esv3892723 CNV loss 25118596
nsv1037878 CNV gain 25217958
nsv1049753 CNV gain 25217958
nsv1112676 CNV deletion 24896259
nsv1141939 OTHER inversion 24896259
nsv1150096 CNV deletion 26484159
nsv118 CNV insertion 15895083
nsv119 CNV insertion 15895083
nsv120 CNV insertion 15895083
nsv1667 CNV insertion 18451855
nsv1668 CNV deletion 18451855
nsv1669 CNV insertion 18451855
nsv1670 CNV insertion 18451855
nsv524871 CNV loss 19592680
nsv570450 CNV loss 21841781
nsv570466 CNV loss 21841781
nsv570470 CNV loss 21841781
nsv819109 CNV gain 19587683
nsv821516 CNV deletion 20802225

Variation tolerance for SLCO3A1 Gene

Residual Variation Intolerance Score: 7.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLCO3A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLCO3A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO3A1 Gene

Disorders for SLCO3A1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLCO3A1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
aneurysmal bone cysts
  • bone cysts aneurysmal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLCO3A1

Genetic Association Database (GAD)
SLCO3A1
Human Genome Epidemiology (HuGE) Navigator
SLCO3A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLCO3A1
genes like me logo Genes that share disorders with SLCO3A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLCO3A1 Gene

Publications for SLCO3A1 Gene

  1. Molecular characterization of human and rat organic anion transporter OATP-D. (PMID: 14631946) Adachi H. … Abe T. (Am. J. Physiol. Renal Physiol. 2003) 3 22 25 65
  2. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (PMID: 10873595) Tamai I. … Tsuji A. (Biochem. Biophys. Res. Commun. 2000) 3 4 25 65
  3. Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. (PMID: 22076464) Ellinghaus E. … Franke A. (Leukemia 2012) 3 46 65
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  5. Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia. (PMID: 18521091) Volpi S. … Lavedan C. (Mol. Psychiatry 2009) 3 46 65

Products for SLCO3A1 Gene

Sources for SLCO3A1 Gene

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