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SLCO2B1 Gene

protein-coding   GIFtS: 61
GCID: GC11P074949

Solute Carrier Organic Anion Transporter Family, Member...

(Previous names: solute carrier family 21 (organic anion transporter), member...)
(Previous symbol: SLC21A9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Solute Carrier Organic Anion Transporter Family, Member 2B11 2     OATP-RP22 3
SLC21A91 2 3 5     OATP2B12 3
OATPB2 3 5     Solute Carrier Organic Anion Transporter Family Member 2B12
Solute Carrier Family 21 (Organic Anion Transporter), Member 91 2     KIAA08803
Organic Anion Transporter B2 3     OATPRP23
Organic Anion Transporter Polypeptide-Related Protein 22 3     Solute Carrier Family 21 Member 93
OATP-B2 3     

External Ids:    HGNC: 109621   Entrez Gene: 113092   Ensembl: ENSG000001374917   OMIM: 6049885   UniProtKB: O949563   
ORGUL members:         

Export aliases for SLCO2B1 gene to outside databases

Previous GC identifers: GC11P074588 GC11P074539 GC11P074862 GC11P071159 GC11P074864 GC11P074901


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLCO2B1 Gene:
This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein
encoded by this locus may function in regulation of placental uptake of sulfated steroids. Alternatively spliced
transcript variants have been described. (provided by RefSeq, Nov 2010)

GeneCards Summary for SLCO2B1 Gene:
SLCO2B1 (solute carrier organic anion transporter family, member 2B1) is a protein-coding gene. Diseases associated with SLCO2B1 include inflammatory bowel disease, and breast and colorectal cancer. GO annotations related to this gene include organic anion transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. An important paralog of this gene is SLCO2A1.

UniProtKB/Swiss-Prot: SO2B1_HUMAN, O94956
Function: Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins
PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost (By similarity)

Gene Wiki entry for SLCO2B1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLCO2B1 gene promoter:
         COUP-TF1   COUP-TF   Sp1   COUP   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLCO2B1 promoter sequence
   Search Chromatin IP Primers for SLCO2B1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLCO2B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13

SLCO2B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO2B1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P074949:  view genomic region     (about GC identifiers)

Start:
74,811,608 bp from pter      End:
74,917,594 bp from pter
Size:
105,987 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SO2B1_HUMAN, O94956 (See protein sequence)
Recommended Name: Solute carrier organic anion transporter family member 2B1  
Size: 709 amino acids; 76711 Da
Sequence caution: Sequence=AAG42205.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA74903.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q9H2Z0 Q9UFU1
Alternative splicing: 2 isoforms:  O94956-1   O94956-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLCO2B1: NX_O94956

Explore proteomics data for SLCO2B1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn176, Asn538
  • Modification sites at PhosphoSitePlus

  • See SLCO2B1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138683.1  NP_001138684.1  NP_009187.1  

    ENSEMBL proteins: 
     ENSP00000432889   ENSP00000289575   ENSP00000434112   ENSP00000432650   ENSP00000436324  
     ENSP00000389653   ENSP00000435384   ENSP00000431192   ENSP00000436513   ENSP00000431324  
     ENSP00000433872   ENSP00000388912   ENSP00000434742   ENSP00000341286  
    Reactome Protein details: O94956

    SLCO2B1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: OATP2B1
    SLCO family of organic anion transporting polypeptides

    3 InterPro protein domains:
     IPR002350 Kazal_dom
     IPR004156 OA_transporter
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry O94956

    ProtoNet protein and cluster: O94956

    1 Blocks protein domain: IPB004156 Organic anion transporter polypeptide (OATP)

    UniProtKB/Swiss-Prot: SO2B1_HUMAN, O94956
    Similarity: Belongs to the organo anion transporter (TC 2.A.60) family
    Similarity: Contains 1 Kazal-like domain


    SLCO2B1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SO2B1_HUMAN, O94956
    Function: Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins
    PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0008514organic anion transmembrane transporter activity IDA18501590
    GO:0015125bile acid transmembrane transporter activity IEA--
    GO:0015347sodium-independent organic anion transmembrane transporter activity IDA18501590
         
    SLCO2B1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Slco2b1):
     immune system 

    SLCO2B1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLCO2B1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLCO2B1
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLCO2B1 (see all 23):
    hsa-miR-125a-5p hsa-miR-300 hsa-miR-765 hsa-miR-520a-5p hsa-miR-320e hsa-miR-3150b-3p hsa-miR-125b hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidSLCO2B1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SLCO2B1

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    Browse Sino Biological Human cDNA Clones
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    PureStem ES-209, Meso-prx/latp Progenitor
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO2B1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SO2B1_HUMAN, O94956: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    peroxisome2
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0016324apical plasma membrane IEA--

    SLCO2B1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLCO2B1 About    
    See pathways by source

    SuperPathContained pathways About
    1Statin Pathway - Generalized, Pharmacokinetics
    Statin Pathway - Generalized, Pharmacokinetics0.50
    Fluvastatin Pathway, Pharmacokinetics0.00
    Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics0.00
    Rosuvastatin Pathway, Pharmacokinetics0.00
    Pravastatin Pathway, Pharmacokinetics0.00
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transmembrane transport of small molecules0.47
    3Transport of vitamins, nucleosides, and related molecules
    Transport of organic anions0.00
    Transport of vitamins, nucleosides, and related molecules

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLCO2B1
        Transport of organic anions

    5 PharmGKB Pathways for SLCO2B1
        Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
    Fluvastatin Pathway, Pharmacokinetics
    Pravastatin Pathway, Pharmacokinetics
    Rosuvastatin Pathway, Pharmacokinetics
    Statin Pathway - Generalized, Pharmacokinetics


    SLCO2B1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SLCO2B1: 
              Drug Transporters in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLCO2B1

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889liver development IEA--
    GO:0006810transport ----
    GO:0015721bile acid and bile salt transport ----
    GO:0043252sodium-independent organic anion transport TAS--
    GO:0055085transmembrane transport TAS--

    SLCO2B1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLCO2B1 (SO2B1)

    1 HMDB Compound for SLCO2B1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Thromboxane B2TXB2 54397-85-2--

    Selected DrugBank Compounds for SLCO2B1 (see all 32)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Conjugated EstrogensEstrogens (see all 10)438-67-5transportersubstrate11683238 11159893 12724351 14610227 15640378
    Pravastatin-- 81093-37-0transportersubstrate inhibitor12724351 14610227 19151602
    Taurocholic Acid-- 81-24-3transportersubstrate14610227 10973807 15640378
    Acetic acidEthanoat (see all 2)64-19-7transportersubstrate inhibitor12724351 14610227
    DinoprostoneDinoprostone Prostaglandin E2 (see all 3)363-24-6transportersubstrate10873595 10973807
    Lactic Acid-- 50-21-5transportersubstrate inhibitor12724351 14610227
    Alprostadil-- 745-65-3transporterinhibitor10973807
    Atorvastatin-- 134523-00-5transporter--17178262
    Benzoic Acid-- 65-85-0transporterinhibitor12724351
    Citric Acid-- 77-92-9transporterinhibitor12724351

    5 IUPHAR Ligands for SLCO2B1 (OATP2B1)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]estrone-3-sulphate
    NoneNone--
    gemfibrozil
    InhibitorInhibition--
    [3H]BSP
    NoneNone--
    rifamycin SV
    InhibitorInhibition--
    glibenclamide
    InhibitorInhibition--

    5 Novoseek inferred chemical compound relationships for SLCO2B1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oatp 91 9 12542534 (2), 20102298 (1)
    estrone sulfate 89.7 12 16714376 (4), 11683238 (4), 20102298 (1)
    estradiol-17beta-glucuronide 82.1 4 11683238 (4)
    ribonucleic acid 42.6 1 17178262 (1)
    steroid 34.9 3 11683238 (2), 19383542 (1)

    1 PharmGKB related drug/compound annotation for SLCO2B1 gene    About this table
    Drug/compound PharmGKB Annotation
    montelukastCA  



    SLCO2B1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLCO2B1 gene (3 alternative transcripts): 
    NM_001145211.2  NM_001145212.2  NM_007256.4  

    Unigene Cluster for SLCO2B1:

    Solute carrier organic anion transporter family, member 2B1
    Hs.7884  [show with all ESTs]
    Unigene Representative Sequence: AK127289
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000526660 ENST00000531713(uc010rrp.1) ENST00000289575(uc001owb.3 uc010rrr.2 uc010rrs.2 uc001owc.3 uc001owd.3)
    ENST00000532236 ENST00000531756(uc010rrq.2) ENST00000531457 ENST00000525650
    ENST00000454962 ENST00000530556 ENST00000534004 ENST00000527180 ENST00000525845
    ENST00000534186 ENST00000428359 ENST00000526839 ENST00000530012 ENST00000528108
    ENST00000530015
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    hsa-miR-125a-5p hsa-miR-300 hsa-miR-765 hsa-miR-520a-5p hsa-miR-320e hsa-miR-3150b-3p hsa-miR-125b hsa-miR-7-1*
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    GenScript: all cDNA clones in your preferred vector (see all 3): SLCO2B1 (NM_007256)
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      QuantiFast Probe-based Assays in human, mouse, rat SLCO2B1

    Additional mRNA sequence: 

    AB020687.1 AB026256.1 AF205073.1 AK127289.1 AK127363.1 AK290234.1 AK294503.1 AK296079.1 
    AK300134.1 AK302492.1 AK304783.1 AL117465.1 AL833466.1 BC041095.1 BC127254.1 FM209049.1 
    FM209050.1 FM209051.1 FM209052.1 FM209053.1 FM209054.1 

    12 DOTS entries:

    DT.116249  DT.91832103  DT.100023475  DT.100775404  DT.97800114  DT.95095394  DT.100775403  DT.92454117 
    DT.120708544  DT.120708534  DT.120708567  DT.99993351 

    Selected AceView cDNA sequences (see all 187):

    AW591768 AA350104 AW769905 AI887596 BM931986 AI419433 AI052501 T33238 
    AW044072 AA346508 BQ185458 AI141669 AV726277 AB020687 T32658 CB160977 
    BQ016374 BC041095 BM504059 NM_007256 AI362602 BG820401 AI401052 BU617422 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLCO2B1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:                                                                                -                 -     -                           
    SP2:                    -                                                           -                 -     -                           
    SP3:                    -     -     -     -                                                                                             
    SP4:                    -     -     -                                                                                                   
    SP5:                    -     -     -     -     -     -     -                                                                           


    ECgene alternative splicing isoforms for SLCO2B1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLCO2B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCTATCAA
    SLCO2B1 Expression
    About this image


    SLCO2B1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced embryoid bodies
     
     Lung (Respiratory System)
     
     Liver (Hepatobiliary System)
     
     Spleen (Hematopoietic System)
    SLCO2B1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLCO2B1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7884
        Pathway & Disease-focused RT2 Profiler PCR Array including SLCO2B1: 
              Drug Transporters in human mouse rat

    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLCO2B1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slco2b11 , 5 solute carrier organic anion transporter family, member more1, 5 79.77(n)1
    75.55(a)1
      7 (54.11 cM)5
    1014881  NM_001252530.11  NP_001239459.11 
     996578045 
    chicken
    (Gallus gallus)
    Aves SLCO2B11 solute carrier organic anion transporter family, member more 63.2(n)
    55.75(a)
      419051  XM_417242.4  XP_417242.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLCO2B16
    solute carrier organic anion transporter family, m...
    49(a)
    1 ↔ 1
    GL343587.1(3818-71301)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.158412 Xenopus laevis transcribed sequence with weak similarity more 75.47(n)    BJ060452.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slco2b11 solute carrier organic anion transporter family, member more 55.06(n)
    49.6(a)
      792084  NM_001037678.2  NP_001032767.2 
    worm
    (Caenorhabditis elegans)
    Secernentea F21G4.11 F21G4.1 41.74(n)
    29.72(a)
      181203  NM_077258.6  NP_509659.3 


    ENSEMBL Gene Tree for SLCO2B1 (if available)
    TreeFam Gene Tree for SLCO2B1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLCO2B1 gene
    SLCO2A12  SLCO4C12  SLCO1B72  ENSG000002570622  SLCO1B32  SLCO3A12  SLCO5A12  SLCO1B12  
    SLCO6A12  SLCO1A22  SLCO1C12  ENSG000002570462  SLCO4A12  
    13 SIMAP similar genes for SLCO2B1 using alignment to 11 protein entries:     SO2B1_HUMAN (see all proteins):
    DKFZp686E0517    SLCO5A1    SLCO3A1    SLCO2A1    SLCO1B1    SLCO1B3
    SLCO1A2    SLCO1B7    SLC21A8    LST3    SLCO1C1    SLCO4A1
    SLCO4C1

    SLCO2B1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLCO2B1 (see all 1233)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364124
    A breast cancer sample4--see VAR_0364122 E K mis40--------
    rs2007292181,2
    Cuntested174779392(+) CCATCA/GACACC 6 N D mis10--------
    rs1394942011,2
    --74725041(+) TACTGC/TATATA 2 -- us2k10--------
    rs28510641,2
    C,F,A,H--74725061(+) GGGGGG/TTATTG 2 -- us2k124Minor allele frequency- T:0.29NS EA NA WA CSA 2352
    rs597090451,2
    C,F--74725102(+) AGGCCG/AGGCGG 2 -- us2k12Minor allele frequency- A:0.06WA 120
    rs1861809531,2
    --74725105(+) CCGGGC/TGGGCA 2 -- us2k10--------
    rs1908971561,2
    --74725248(+) GTGTGA/GTGGCA 2 -- us2k10--------
    rs1823267141,2
    --74725322(+) GAGGTC/TGCAGT 2 -- us2k10--------
    rs28510651,2
    C,F,A--74725323(+) AGGTTT/GCAGTG 2 -- us2k15Minor allele frequency- G:0.30NA WA 10
    rs1475920371,2
    C--74725460(+) AAGCTG/TGTCCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLCO2B1 (74811608 - 74917594 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SLCO2B1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897919CNV Loss21882294

    Human Gene Mutation Database (HGMD): SLCO2B1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLCO2B1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLCO2B1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604988    OMIM disorders: --

    8 diseases for SLCO2B1:    
    About MalaCards
    inflammatory bowel disease    breast and colorectal cancer    breast cancer    prostate cancer
    prostatitis    colorectal cancer    hepatitis    endotheliitis


    SLCO2B1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SLCO2B1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 7.62 5 17214375 (3), 17991769 (1)

    Genetic Association Database (GAD): SLCO2B1
    Human Genome Epidemiology (HuGE) Navigator: SLCO2B1 (15 documents)

    Export disorders for SLCO2B1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLCO2B1 gene, integrated from 10 sources (see all 71):
    (articles sorted by number of sources associating them with SLCO2B1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (PubMed id 10873595)1, 2, 7 Tamai I.... Tsuji A. (Biochem. Biophys. Res. Commun. 2000)
    2. High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). (PubMed id 15226675)1, 4, 9 Niemi M....KivistAP K.T. (Pharmacogenetics 2004)
    3. Impact of regulatory polymorphisms in organic anion transporter genes in the human liver. (PubMed id 19620935)1, 4 Aoki M....Inui K. (Pharmacogenet. Genomics 2009)
    4. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    5. Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1. (PubMed id 16754786)1, 2 Hanggi E.... St-Pierre M.V. (Mol. Pharmacol. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis. (PubMed id 12130747)1, 4 Nozawa T....Yokoi T. (J. Pharmacol. Exp. Ther. 2002)
    8. Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. (PubMed id 11159893)1, 7 Kullak-Ublick G.A....Hagenbuch B. (Gastroenterology 2001)
    9. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    10. Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C. (PubMed id 11683238)7, 9 Tamai I....Tsuji A. (Pharm. Res. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11309 HGNC: 10962 AceView: SLCO2B1 Ensembl:ENSG00000137491 euGenes: HUgn11309
    ECgene: SLCO2B1 H-InvDB: SLCO2B1

    (According to HUGE)
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    HUGE: KIAA0880

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLCO2B1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLCO2B1 gene:
    Search GeneIP for patents involving SLCO2B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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