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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLCO2B1 Gene

protein-coding GIFtS: 57
GCID: GC11P074864

solute carrier organic anion transporter family, member...

(Previous names: solute carrier family 21 (organic anion transporter), member...)
(Previous symbol: SLC21A9)

Explore 4 diseases affiliated with
SLCO2B1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Organic Anion Transporter Family, Member 2B1¹ ²		Organic Anion Transporter Polypeptide-Related Protein 2² ³
SLC21A9¹ ² ³ ⁵		OATP-RP2² ³
OATP-B¹ ² ³		Solute Carrier Organic Anion Transporter Family Member 2B1²
OATP2B1¹ ² ³		KIAA0880³
OATPB² ³ ⁵		OATPRP2³
Solute Carrier Family 21 (Organic Anion Transporter), Member 9¹ ²		Solute Carrier Family 21 Member 9³
Organic Anion Transporter B² ³

External Ids:	HGNC: 10962¹	Entrez Gene: 11309²	Ensembl: ENSG00000137491⁷	OMIM: 604988⁵	UniProtKB: O94956³

Export aliases for SLCO2B1 gene to outside databases

Previous GC identifers: GC11P074588 GC11P074539 GC11P074862 GC11P071159

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLCO2B1:

This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein

encoded by this locus may function in regulation of placental uptake of sulfated steroids. Alternatively spliced

transcript variants have been described. (provided by RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: SO2B1_HUMAN, O94956

Function: Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2,

PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost (By similarity)

Gene Wiki entry for SLCO2B1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLCO2B1 gene promoter:
COUP-TF1 COUP-TF Sp1 COUP HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLCO2B1 promoter sequence

Search SABiosciences Chromatin IP Primers for SLCO2B1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLCO2B1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13

SLCO2B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO2B1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P074864: view genomic region (about GC identifiers)

Start:	74,811,608 bp from pter	End:	74,917,594 bp from pter
Size:	105,987 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SO2B1_HUMAN, O94956 (See protein sequence)

Recommended Name: Solute carrier organic anion transporter family member 2B1

Size: 709 amino acids; 76711 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Sequence caution: Sequence=AAG42205.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAA74903.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: Q9H2Z0 Q9UFU1

Alternative splicing: 2 isoforms: O94956-1 O94956-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLCO2B1: NX_O94956

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O94956

SLCO2B1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001138683.1 NP_001138684.1 NP_009187.1

ENSEMBL proteins:

ENSP00000432889 ENSP00000289575 ENSP00000434112 ENSP00000432650 ENSP00000436324

ENSP00000389653 ENSP00000435384 ENSP00000431192 ENSP00000436513 ENSP00000431324

ENSP00000433872 ENSP00000388912 ENSP00000434742 ENSP00000341286

Reactome Protein details: O94956
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLCO2B1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--
GO:0016324	apical plasma membrane	IEA	--

SLCO2B1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SLCO2B1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLCO2B1 for domains About GeneDecksing

2 InterPro domains/families:

IPR004156 OA_transporter

IPR016196 MFS_dom_general_subst_transpt

Graphical View of Domain Structure for InterPro Entry O94956

ProtoNet protein and cluster: O94956

1 Blocks protein family: IPB004156 Organic anion transporter polypeptide (OATP)

UniProtKB/Swiss-Prot: SO2B1_HUMAN, O94956

Similarity: Belongs to the organo anion transporter (TC 2.A.60) family

Similarity: Contains 1 Kazal-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SO2B1_HUMAN, O94956

Function: Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2,

PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost (By similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): SLCO2B1 Browse MicroRNA Expression Plasmids
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		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate SLCO2B1 (see all 23):
		hsa-miR-125a-5p hsa-miR-300 hsa-miR-765 hsa-miR-520a-5p hsa-miR-320e hsa-miR-3150b-3p hsa-miR-125b hsa-miR-7-1*

		SwitchGear 3'UTR luciferase reporter plasmid: SLCO2B1 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO2B1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	--	--
GO:0008514	organic anion transmembrane transporter activity	IDA	18501590
GO:0015347	sodium-independent organic anion transmembrane transporter activity	IDA	18501590

SLCO2B1 for ontologies About GeneDecksing

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Slco2b1):

immune system

SLCO2B1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics

	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics	1.00			Statin Pathway - Generalized, Pharmacokinetics	0.70
	Fluvastatin Pathway, Pharmacokinetics	0.80

Transport of organic anions

Transport of organic anions

1.00

Transport of vitamins, nucleosides, and related molecules

0.35

SLC-mediated transmembrane transport

SLC-mediated transmembrane transport

1.00

Transmembrane transport of small molecules

0.50

Pravastatin Pathway, Pharmacokinetics

Pravastatin Pathway, Pharmacokinetics

1.00

Rosuvastatin Pathway, Pharmacokinetics

0.44

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for SLCO2B1

	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Transport of vitamins, nucleosides, and related molecules
	Transport of organic anions

5 PharmGKB Pathways for SLCO2B1

	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
	Fluvastatin Pathway, Pharmacokinetics
	Pravastatin Pathway, Pharmacokinetics
	Rosuvastatin Pathway, Pharmacokinetics
	Statin Pathway - Generalized, Pharmacokinetics

SLCO2B1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLCO2B1

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015711	organic anion transport	--	--
GO:0043252	sodium-independent organic anion transport	TAS	--
GO:0055085	transmembrane transport	TAS	--

SLCO2B1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SLCO2B1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLCO2B1

1 HMDB Compound for SLCO2B1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Thromboxane B2	TXB2	54397-85-2	--

10/28 DrugBank Compounds for SLCO2B1 (see all 28) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Conjugated Estrogens	Estrogens (see all 10)	438-67-5	transporter	substrate	11683238 11159893 12724351 14610227 15640378
Pravastatin	Pravastatin Sodium (see all 4)	81093-37-0	transporter	substrate inhibitor	12724351 14610227 19151602
Taurocholic Acid	--	81-24-3	transporter	substrate	14610227 10973807 15640378
Acetic acid	Ethanoat (see all 2)	64-19-7	transporter	substrate inhibitor	12724351 14610227
Dinoprostone	Dinoprostone Prostaglandin E2 (see all 3)	363-24-6	transporter	substrate	10873595 10973807
Lactic Acid	--	50-21-5	transporter	substrate inhibitor	12724351 14610227
Alprostadil	--	745-65-3	transporter	inhibitor	10973807
Benzoic Acid	--	65-85-0	transporter	inhibitor	12724351
Citric Acid	--	77-92-9	transporter	inhibitor	12724351
Digoxin	--	20830-75-5	transporter	substrate	10973807

5 Novoseek chemical compound relationships for SLCO2B1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
oatp	91	9	12542534 (2), 20102298 (1)
estrone sulfate	89.7	12	16714376 (4), 11683238 (4), 20102298 (1)
estradiol-17beta-glucuronide	82.1	4	11683238 (4)
ribonucleic acid	42.6	1	17178262 (1)
steroid	34.9	3	11683238 (2), 19383542 (1)

1 PharmGKB related drug/compound annotation for SLCO2B1 gene

Drug/compound	PharmGKB Annotation
montelukast	CA

About this table

Search CenterWatch for drugs/clinical trials and news about SLCO2B1 / SO2B1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLCO2B1 gene (3 alternative transcripts):

NM_001145211.2 NM_001145212.2 NM_007256.4

Unigene Cluster for SLCO2B1:

Solute carrier organic anion transporter family, member 2B1

Hs.7884 [show with all ESTs]

Unigene Representative Sequence: AK127289

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000526660 ENST00000531713(uc010rrp.1) ENST00000289575(uc001owb.3 uc010rrr.2 uc010rrs.2 uc001owc.3 uc001owd.3)

ENST00000532236 ENST00000531756(uc010rrq.2) ENST00000531457 ENST00000525650

ENST00000454962 ENST00000530556 ENST00000534004 ENST00000527180 ENST00000525845

ENST00000534186 ENST00000428359 ENST00000526839 ENST00000530012 ENST00000528108

ENST00000530015

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		hsa-miR-125a-5p hsa-miR-300 hsa-miR-765 hsa-miR-520a-5p hsa-miR-320e hsa-miR-3150b-3p hsa-miR-125b hsa-miR-7-1*

		SwitchGear 3'UTR luciferase reporter plasmid: SLCO2B1 3' UTR sequence

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Additional cDNA sequence:

AB020687.1 AB026256.1 AF205073.1 AK127289.1 AK127363.1 AK290234.1 AK294503.1 AK296079.1

AK300134.1 AK302492.1 AK304783.1 AL117465.1 AL833466.1 BC041095.1 BC127254.1 FM209049.1

FM209050.1 FM209051.1 FM209052.1 FM209053.1 FM209054.1

12 DOTS entries:

DT.116249 DT.91832103 DT.100023475 DT.100775404 DT.97800114 DT.95095394 DT.100775403 DT.92454117

DT.120708544 DT.120708534 DT.120708567 DT.99993351

24/187 AceView cDNA sequences (see all 187):

BG820401 BQ185458 AI224416 BM919645 AI887596 BQ186012 CA448920 AL698793

CB160977 AI828362 AL117465 AI401052 BQ187803 AB020687 BC041095 AI952908

AI052501 NM_007256 AW769905 AI904102 AA984749 BM931986 AA350104 T33238

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SLCO2B1 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	^	14	^	15a	·	15b
SP1:																											-						-		-
SP2:							-																				-						-		-
SP3:							-		-		-		-
SP4:							-		-		-
SP5:							-		-		-		-		-		-		-

ECgene alternative splicing isoforms for SLCO2B1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLCO2B1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATCTATCAA

About this image

SLCO2B1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLCO2B1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLCO2B1

SOURCE GeneReport for Unigene cluster: Hs.7884

SABiosciences Expression via Pathway-Focused PCR Array including SLCO2B1:

Drug Transporters in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO2B1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SLCO2B1 gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLCO2B1¹	solute carrier organic anion transporter family, member more	63.41(n) 55.84(a)		419051 XM_417242.3 XP_417242.3
lizard (Anolis carolinensis)	Reptilia	SLCO2B1⁶	--	49(a)	1 ↔ 1	GL343587.1(3818-71301)
African clawed frog (Xenopus laevis)	Amphibia	Xl.15841²	Xenopus laevis transcribed sequence with weak similarity more	75.47(n)		BJ060452.1
zebrafish (Danio rerio)	Actinopterygii	slco2b1¹	solute carrier organic anion transporter family, member more	55.16(n) 49.44(a)		792084 NM_001037678.2 NP_001032767.2
fruit fly (Drosophila melanogaster)	Insecta	Oatp33Ea⁶ Oatp58Db⁶ (see all 7)	Organic anion transporting polypeptide 58Db (see all 7)	20(a) 20(a) (see all 7)	many ↔ many many ↔ many (see all 7)	2L(12441401-12445924) 2R(18108685-18111095)
worm (Caenorhabditis elegans)	Secernentea	F21G4.1¹	Protein F21G4.1	42(n) 29.81(a)		181203 NM_077258.5 NP_509659.3

ENSEMBL Gene Tree for SLCO2B1 (if available)
TreeFam Gene Tree for SLCO2B1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLCO2B1 gene

SLCO2A1² SLCO4C1² SLCO1B7² ENSG00000257062² SLCO3A1² SLCO1B3² SLCO5A1² SLCO6A1²

SLCO1B1² ENSG00000257046² SLCO4A1² SLCO1A2² SLCO1C1²

13 SIMAP similar genes for SLCO2B1 using alignment to 11 protein entries: SO2B1_HUMAN (see all proteins):

DKFZp686E0517 SLCO5A1 SLCO3A1 SLCO2A1 SLCO1B1 SLCO1B3

SLCO1A2 SLCO1B7 SLC21A8 SLCO1C1 SLCO4A1 LST3

SLCO4C1

SLCO2B1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200729218^1,2	C,	other	96739260(+)	`CCATCA/GACACC`	6	N D	mis¹		0	--	--	--	--
rs59709045^1,2	C,	--	71157678(+)	`AGGCCG/AGGCGG`	2	--	us2k¹		2		WA	120
rs77048806^1,2	F,	--	71159163(+)	`CCCCTC/ACTCCT`	2	--	us2k¹		1		WA	118
rs58991765^1,2	C,F,	--	71159562(+)	`CTGCTA/CACAGA`	2	--	us2k¹		5		WA CSA	649
rs72998506^1,2		--	71161068(+)	`CTTGGA/GGACTG`	2	--	int¹		0	--	--	--	--
rs112643363^1,2	C,	--	71161079(+)	`CAGTAC/TGGCAG`	2	--	int¹		2		NA	122
rs12418440^1,2	H	--	71161169(+)	`GGGGGG/TCGGTG`	2	--	int¹		0	--	--	--	--
rs76743386^1,2	C,	--	71161244(+)	`AGAGCG/AGGGAG`	2	--	int¹		2		WA	120
rs57573811^1,2	C,F,	--	71161356(+)	`CAGGTG/TCCCAC`	2	--	int¹		3		WA CSA	6
rs61259856^1,2	C,F,	--	71161652(+)	`TTAGGC/TAGCAG`	2	--	int¹		3		WA	122

HapMap Linkage Disequilibrium report for SLCO2B1 (74811608 - 74917594 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLCO2B1: --
Human Gene Mutation Database (HGMD): SLCO2B1

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SLCO2B1 for disorders           About GeneDecksing

OMIM gene information: 604988    OMIM disorders: --

4 diseases for SLCO2B1:    About MalaCards

inflammatory bowel disease breast cancer prostate cancer prostatitis

1 Novoseek disease relationship for SLCO2B1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	7.62	5	17214375 (3), 17991769 (1)

Genetic Association Database (GAD): SLCO2B1
Human Genome Epidemiology (HuGE) Navigator: SLCO2B1 (15 documents)

Export disorders for SLCO2B1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SLCO2B1 gene, integrated from 9 sources (see all 63):
(articles sorted by number of sources associating them with SLCO2B1)

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Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (PubMed id 10873595)^{1, 2, 7} Tamai I.... Tsuji A. (2000)
High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). (PubMed id 15226675)^{1, 4, 9} Niemi M....Kivisto K.T. (2004)
Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1. (PubMed id 16754786)^{1, 2} Hanggi E....St-Pierre M.V. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis. (PubMed id 12130747)^{1, 4} Nozawa T....Yokoi T. (2002)
Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. (PubMed id 11159893)^{1, 7} Kullak-Ublick G.A....Hagenbuch B. (2001)
Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)^{1, 2} Nagase T....Ohara O. (1998)
Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C. (PubMed id 11683238)^{7, 9} Tamai I....Tsuji A. (2001)
Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta. (PubMed id 11932330)^{1, 9} St-Pierre M.V....Stallmach T. (2002)
Transcriptional control of human organic anion transporting polypeptide 2B1 gene. (PubMed id 19383542)^{1, 9} Pomari E....Dalla Valle L. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 11309	HGNC: 10962	AceView: SLCO2B1	Ensembl:ENSG00000137491	euGenes: HUgn11309
ECgene: SLCO2B1	H-InvDB: SLCO2B1

(According to HUGE)
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HUGE: KIAA0880

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SLCO2B1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLCO2B1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SLCO2B1 gene:
Search GeneIP for patents involving SLCO2B1

GeneCards and IP:
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