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SLCO2A1 Gene

protein-coding   GIFtS: 62
GCID: GC03M133651

Solute Carrier Organic Anion Transporter Family, Member...

(Previous names: solute carrier family 21 (prostaglandin transporter), member...)
(Previous symbols: SLC21A2, MATR1)
  See SLCO2A1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Organic Anion Transporter Family, Member 2A11 2     Solute Carrier Family 21 (Prostaglandin Transporter), Member 21 2
SLC21A21 2 3 5     Prostaglandin Transporter2 3
OATP2A12 3 5     Solute Carrier Family 21 Member 22 3
PGT2 3 5     PHOAR22 5
MATR11 2     Solute Carrier Organic Anion Transporter Family Member 2A12
Matrin F/G 11 2     

External Ids:    HGNC: 109551   Entrez Gene: 65782   Ensembl: ENSG000001746407   OMIM: 6014605   UniProtKB: Q929593   

Export aliases for SLCO2A1 gene to outside databases

Previous GC identifers: GC03M134972 GC03M135134 GC03M131029


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLCO2A1 Gene:
This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of
transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in
numerous tissues. (provided by RefSeq, Dec 2011)

GeneCards Summary for SLCO2A1 Gene:
SLCO2A1 (solute carrier organic anion transporter family, member 2A1) is a protein-coding gene. Diseases associated with SLCO2A1 include secondary hypertrophic osteoarthropathy, and hypertrophic osteoarthropathy, primary, autosomal recessive 2. GO annotations related to this gene include prostaglandin transmembrane transporter activity and lipid transporter activity. An important paralog of this gene is SLCO4C1.

UniProtKB/Swiss-Prot: SO2A1_HUMAN, Q92959
Function: May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of
prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2
and PGF2A

Gene Wiki entry for SLCO2A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLCO2A1 gene promoter:
         STAT1   NF-1   NF-1/L   STAT1beta   CUTL1   Cdc5   STAT1alpha   GATA-1   AREB6   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLCO2A1 promoter sequence
   Search Chromatin IP Primers for SLCO2A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLCO2A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21   Ensembl cytogenetic band:  3q22.2   HGNC cytogenetic band: 3q21

SLCO2A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO2A1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M133651:  view genomic region     (about GC identifiers)

Start:
133,651,540 bp from pter      End:
133,771,028 bp from pter
Size:
119,489 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SO2A1_HUMAN, Q92959 (See protein sequence)
Recommended Name: Solute carrier organic anion transporter family member 2A1  
Size: 643 amino acids; 70044 Da
1 PDB 3D structure from and Proteopedia for SLCO2A1:
3MRR (3D)    
Secondary accessions: Q86V98 Q8IUN2

Explore the universe of human proteins at neXtProt for SLCO2A1: NX_Q92959

Explore proteomics data for SLCO2A1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn134, Asn478, Asn491
  • Modification sites at PhosphoSitePlus

  • See SLCO2A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005621.2  
    ENSEMBL proteins: 
     ENSP00000311291   ENSP00000418893   ENSP00000420028  
    Reactome Protein details: Q92959

    SLCO2A1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: OATP2A1
    SLCO family of organic anion transporting polypeptides

    4 InterPro protein domains:
     IPR002350 Kazal_dom
     IPR004156 OA_transporter
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q92959

    ProtoNet protein and cluster: Q92959

    2 Blocks protein domains:
    IPB004156 Organic anion transporter polypeptide (OATP)
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: SO2A1_HUMAN, Q92959
    Similarity: Belongs to the organo anion transporter (TC 2.A.60) family
    Similarity: Contains 1 Kazal-like domain


    Find genes that share domains with SLCO2A1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SO2A1_HUMAN, Q92959
    Function: May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of
    prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2
    and PGF2A

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005319lipid transporter activity TAS8787677
    GO:0005515protein binding ----
    GO:0015132prostaglandin transmembrane transporter activity IEA--
         
    Find genes that share ontologies with SLCO2A1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SLCO2A1:
     Decreased cell number  G0/1 arrest  Lamellipodia cells 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slco2a1):
     cardiovascular system  cellular  homeostasis/metabolism  mortality/aging  renal/urinary system 

    Find genes that share phenotypes with SLCO2A1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slco2a1tm1.2Vsch for SLCO2A1

       genOway: Develop your customized and physiologically relevant rodent model for SLCO2A1

    miRNA
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    miRTarBase miRNAs that target SLCO2A1:
    hsa-mir-181a-5p (MIRT025150)

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    hsa-miR-548p hsa-miR-125a-5p hsa-miR-3607-5p hsa-miR-3184 hsa-miR-4251 hsa-miR-1224-3p hsa-miR-4299 hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidSLCO2A1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SO2A1_HUMAN, Q92959: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8787677
    GO:0016020membrane TAS8787677
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with SLCO2A1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLCO2A1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transmembrane transport of small molecules0.47
    2Transport of vitamins, nucleosides, and related molecules
    Transport of organic anions0.00
    Transport of vitamins, nucleosides, and related molecules
    3Ca-dependent events
    Neurophysiological process PGE2 induced pain processing0.38


    Find genes that share SuperPaths with SLCO2A1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for SLCO2A1
        Neurophysiological process PGE2-induced pain processing

    1 Reactome Pathway for SLCO2A1
        Transport of organic anions


        Pathway & Disease-focused RT2 Profiler PCR Array including SLCO2A1: 
              Drug Transporters in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLCO2A1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLCO2A1 (Q929591, 3 ENSP000003112914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 3, ENSP000003390074EBI-1760532,EBI-401755 I2D: score=1 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006869lipid transport TAS8787677
    GO:0015732prostaglandin transport ----
    GO:0043252sodium-independent organic anion transport TAS--
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with SLCO2A1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLCO2A1 (SO2A1)

    Selected DrugBank Compounds for SLCO2A1 (see all 13)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alprostadil-- 745-65-3transportersubstrate8787677 7754369
    DinoprostoneDinoprostone Prostaglandin E2 (see all 3)363-24-6transportersubstrate8787677 7754369
    Iloprost-- 78919-13-8transportersubstrate8787677 7754369
    Arachidonic Acid-- 506-32-1transportersubstrate7754369
    Dinoprost TromethamineDinoprost, trometamol salt (see all 7)38562-01-5transporter--8787677
    Fructose-1,6-Diphosphate-- --transporterinhibitor11997326
    FurosemideDihydroflumethiazide (see all 12)54-31-9transporterinhibitor7754369
    Glucose-6-Phosphate-- 56-73-5transporterinhibitor11997326
    Glyceraldehyde-3-Phosphate-- 142-10-9transporterinhibitor11997326
    Lactic Acid-- 50-21-5transporterinhibitor11997326

    3 IUPHAR Ligands for SLCO2A1 (OATP2A1)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]PGE2
    NoneNone--
    BSP
    InhibitorInhibition--
    bromocresol green
    InhibitorInhibition--

    8 Novoseek inferred chemical compound relationships for SLCO2A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostaglandin 84.1 55 15044627 (3), 15657371 (2), 16842938 (2), 14631946 (2) (see all 29)
    (+-)-pgf2-alpha 77.4 2 15044627 (1)
    oatp 70.2 2 10601278 (1)
    pge2 63.6 11 15044627 (3), 14631946 (1), 19138942 (1), 9506966 (1)
    prostaglandin f2alpha 58.1 1 11093791 (1)
    pge1 38.4 1 14631946 (1)
    indomethacin 29.3 1 12630701 (1)
    atp 0 1 12630701 (1)



    Find genes that share compounds with SLCO2A1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLCO2A1 gene: 
    NM_005630.2  

    Unigene Cluster for SLCO2A1:

    Solute carrier organic anion transporter family, member 2A1
    Hs.518270  [show with all ESTs]
    Unigene Representative Sequence: NM_005630
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310926(uc003eqa.4) ENST00000493729 ENST00000481359 ENST00000462770(uc011blv.2)
    ENST00000477061 ENST00000464676(uc010htw.1) ENST00000478651 ENST00000478662

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    hsa-miR-548p hsa-miR-125a-5p hsa-miR-3607-5p hsa-miR-3184 hsa-miR-4251 hsa-miR-1224-3p hsa-miR-4299 hsa-miR-1205
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    Additional mRNA sequence: 

    AK303550.1 AK309561.1 BC041140.1 BC051347.1 U70867.1 

    8 DOTS entries:

    DT.314904  DT.95229652  DT.100748492  DT.120894286  DT.120894293  DT.70101265  DT.91690159  DT.91747746 

    Selected AceView cDNA sequences (see all 143):

    BF589463 AI424234 AI492517 BF446356 BQ005081 BM128901 CA443557 BF111670 
    BM988738 AI376659 AA887582 BM504792 AW583761 BQ102463 BU741978 BQ272209 
    AI474048 BG055100 AW304821 BU784458 AW592709 AA913860 BM710461 BM312407 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLCO2A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAATTTAAC
    SLCO2A1 Expression
    About this image


    SLCO2A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Podocytes Podocyte Layer
             Proximal Tubule
     
     Epithelial Cells
             Podocytes Podocyte Layer
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Definitive endoderm-like cells
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
    SLCO2A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLCO2A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518270

    UniProtKB/Swiss-Prot: SO2A1_HUMAN, Q92959
    Tissue specificity: Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart

        Pathway & Disease-focused RT2 Profiler PCR Array including SLCO2A1: 
              Drug Transporters in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO2A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLCO2A1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slco2a11 , 5 solute carrier organic anion transporter family, member more1, 5 84.84(n)1
    83.33(a)1
      9 (54.72 cM)5
    240591  NM_033314.31  NP_201571.21 
     1030084895 
    chicken
    (Gallus gallus)
    Aves SLCO2A11 solute carrier organic anion transporter family, member more 71.41(n)
    66.77(a)
      424862  NM_001198927.1  NP_001185856.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLCO2A16
    solute carrier organic anion transporter family, m...
    52(a)
    1 ↔ 1
    3(31013525-31165221)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686572 hypothetical protein MGC68657 75.05(n)    BC060473.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slco2a16
    solute carrier organic anion transporter family, m...
    55(a)
    1 ↔ 1
    6(27332251-27373486) ENSDARG00000061896


    ENSEMBL Gene Tree for SLCO2A1 (if available)
    TreeFam Gene Tree for SLCO2A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLCO2A1 gene
    SLCO4C12  SLCO1B72  ENSG000002570622  SLCO1B32  SLCO3A12  SLCO2B12  SLCO5A12  SLCO1B12  
    SLCO6A12  SLCO1A22  SLCO1C12  ENSG000002570462  SLCO4A12  
    15 SIMAP similar genes for SLCO2A1 using alignment to 3 protein entries:     SO2A1_HUMAN (see all proteins):
    SLC21A2    SLCO2B1    SLCO1A2    SLCO1B3    SLCO1B1    SLCO4A1
    SLCO4C1    SLCO3A1    SLCO5A1    LST3    SLCO1B7    SLCO6A1
    SPINK7    SLC21A8    SLCO1C1

    Find genes that share paralogs with SLCO2A1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLCO2A1 (see all 2206)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0686414
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4--see VAR_0686412 G R mis40--------
    VAR_0686384
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4--see VAR_0686382 G A mis40--------
    VAR_0683524
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4--see VAR_0683522 F S mis40--------
    VAR_0686404
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4--see VAR_0686402 S L mis40--------
    VAR_0686424
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4--see VAR_0686422 C F mis40--------
    VAR_0686394
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4--see VAR_0686392 G D mis40--------
    VAR_0686454
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4--see VAR_0686452 W G mis40--------
    VAR_0675994
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4--see VAR_0675992 G E mis40--------
    VAR_0686374
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4--see VAR_0686372 R H mis40--------
    VAR_0686444
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4--see VAR_0686442 Q H mis40--------

    HapMap Linkage Disequilibrium report for SLCO2A1 (133651540 - 133771028 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SLCO2A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725945CNV Deletion23290073
    esv1546500CNV Deletion17803354
    esv2725944CNV Deletion23290073
    esv2222789CNV Deletion18987734
    nsv527655CNV Loss19592680
    nsv877509CNV Gain21882294

    Human Gene Mutation Database (HGMD): SLCO2A1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLCO2A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLCO2A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601460   
    OMIM disorders: 614441  
    UniProtKB/Swiss-Prot: SO2A1_HUMAN, Q92959
  • Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2) [MIM:614441]: A disease
    characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features
    of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include
    delayed closure of the cranial sutures and congenital heart disease. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 4 diseases for SLCO2A1:    
    About MalaCards
    secondary hypertrophic osteoarthropathy    hypertrophic osteoarthropathy, primary, autosomal recessive 2    primary hypertrophic osteoarthropathy    cranio osteoarthropathy

    2 diseases from the University of Copenhagen DISEASES database for SLCO2A1:
    Primary hypertrophic osteoarthropathy     Secondary hypertrophic osteoarthropathy

    Find genes that share disorders with SLCO2A1           About GenesLikeMe

    Genetic Association Database (GAD): SLCO2A1
    Human Genome Epidemiology (HuGE) Navigator: SLCO2A1 (3 documents)

    Export disorders for SLCO2A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLCO2A1 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with SLCO2A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT). (PubMed id 8787677)1, 2, 3, 7, 9 Lu R.... Schuster V.L. (J. Clin. Invest. 1996)
    2. Molecular cloning of the gene for the human prostaglandin transporter hPGT: gene organization, promoter activity, and chromosomal localization. (PubMed id 9618293)1, 2, 3 Lu R. and Schuster V.L. (Biochem. Biophys. Res. Commun. 1998)
    3. Mutations in the prostaglandin transporter SLCO2A1 cause primary hypertrophic osteoarthropathy with digital clubbing. (PubMed id 22696055)1, 2 Busch J.... Bergmann C. (J. Invest. Dermatol. 2012)
    4. Mutations in the prostaglandin transporter encoding gene SLCO2A1 cause primary hypertrophic osteoarthropathy and isolated digital clubbing. (PubMed id 22331663)1, 2 Seifert W.... Horn D. (Hum. Mutat. 2012)
    5. Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy. (PubMed id 22197487)1, 2 Zhang Z.... Liu Y. (Am. J. Hum. Genet. 2012)
    6. Prostaglandin transporter mutations cause pachydermoperiostosis with myelofibrosis. (PubMed id 22553128)1, 2 Diggle C.P.... Bonthron D.T. (Hum. Mutat. 2012)
    7. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    8. Genetic factors related to unconjugated hyperbilirubinemia amongst adults. (PubMed id 15864125)1, 4 Huang C.S....Tang K.S. (Pharmacogenet. Genomics 2005)
    9. Regulation of prostaglandin transporters in colorectal neoplasia. (PubMed id 19138942)1, 9 Holla V.R....DuBois R.N. (Cancer Prev Res (Phila) 2008)
    10. Expression and localization of prostaglandin transporter in Alzheimer disease brains and age-matched controls. (PubMed id 18353443)1, 9 Choi K....DorAc S. (J. Neuroimmunol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6578 HGNC: 10955 AceView: SLCO2A1 Ensembl:ENSG00000174640 euGenes: HUgn6578
    ECgene: SLCO2A1 H-InvDB: SLCO2A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLCO2A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLCO2A1 gene:
    Search GeneIP for patents involving SLCO2A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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