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Aliases for SLCO2A1 Gene

Aliases for SLCO2A1 Gene

  • Solute Carrier Organic Anion Transporter Family Member 2A1 2 3 5
  • Solute Carrier Family 21 (Prostaglandin Transporter), Member 2 2 3
  • Matrin F/G 1 2 3
  • SLC21A2 3 4
  • OATP2A1 3 4
  • PGT 3 4
  • Solute Carrier Organic Anion Transporter Family, Member 2A1 2
  • Solute Carrier Family 21 Member 2 4
  • Prostaglandin Transporter 4
  • PHOAR2 3
  • MATR1 3

External Ids for SLCO2A1 Gene

Previous HGNC Symbols for SLCO2A1 Gene

  • SLC21A2
  • MATR1

Previous GeneCards Identifiers for SLCO2A1 Gene

  • GC03M134972
  • GC03M135134
  • GC03M133651
  • GC03M131029

Summaries for SLCO2A1 Gene

Entrez Gene Summary for SLCO2A1 Gene

  • This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011]

GeneCards Summary for SLCO2A1 Gene

SLCO2A1 (Solute Carrier Organic Anion Transporter Family Member 2A1) is a Protein Coding gene. Diseases associated with SLCO2A1 include Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 2 and Chronic Enteropathy Associated With Slco2a1 Gene. Among its related pathways are DAG and IP3 signaling and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and prostaglandin transmembrane transporter activity. An important paralog of this gene is SLCO2B1.

UniProtKB/Swiss-Prot for SLCO2A1 Gene

  • May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

Gene Wiki entry for SLCO2A1 Gene

Additional gene information for SLCO2A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO2A1 Gene

Genomics for SLCO2A1 Gene

GeneHancer (GH) Regulatory Elements for SLCO2A1 Gene

Promoters and enhancers for SLCO2A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I134029 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 562.6 +22.4 22361 0.8 ZSCAN4 KLF17 ZNF76 ZNF335 GLIS2 ZNF366 KLF7 ZNF391 EGR2 SP3 SLCO2A1 GC03M133943
GH03I134091 Enhancer 1 FANTOM5 ENCODE 13 -41.4 -41372 3.7 JUN MAX ZNF384 FEZF1 ZIC2 RAD21 BRCA1 ZFHX2 POLR2A SCRT2 SLCO2A1 RYK LOC105374117 GC03M134152
GH03I133942 Enhancer 1.1 Ensembl ENCODE 10.4 +107.6 107623 4.3 HDAC1 NFIB INSM2 FEZF1 TCF12 ZNF366 ZSCAN5C FOS ETV6 ZNF362 SLCO2A1 C3orf36 GC03M133943
GH03I134030 Enhancer 0.4 FANTOM5 23.9 +23.1 23088 0.1 SUZ12 EZH2 C3orf36 SLCO2A1 GC03M133943
GH03I134008 Enhancer 0.8 Ensembl ENCODE 11.5 +43.1 43100 2.1 STAT1 NFIB JUN CEBPB EP300 ZNF217 JUND GATA3 POLR2A ESR1 SLCO2A1 C3orf36 GC03M133943
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLCO2A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLCO2A1 gene promoter:

Genomic Locations for SLCO2A1 Gene

Genomic Locations for SLCO2A1 Gene
chr3:133,932,696-134,052,184
(GRCh38/hg38)
Size:
119,489 bases
Orientation:
Minus strand
chr3:133,651,540-133,771,028
(GRCh37/hg19)

Genomic View for SLCO2A1 Gene

Genes around SLCO2A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO2A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO2A1 Gene

Proteins for SLCO2A1 Gene

  • Protein details for SLCO2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92959-SO2A1_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 2A1
    Protein Accession:
    Q92959
    Secondary Accessions:
    • Q86V98
    • Q8IUN2

    Protein attributes for SLCO2A1 Gene

    Size:
    643 amino acids
    Molecular mass:
    70044 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SLCO2A1 Gene

neXtProt entry for SLCO2A1 Gene

Post-translational modifications for SLCO2A1 Gene

No Post-translational modifications

Other Protein References for SLCO2A1 Gene

No data available for DME Specific Peptides for SLCO2A1 Gene

Domains & Families for SLCO2A1 Gene

Gene Families for SLCO2A1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Potential drug targets
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLCO2A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92959

UniProtKB/Swiss-Prot:

SO2A1_HUMAN :
  • Belongs to the organo anion transporter (TC 2.A.60) family.
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO2A1: view

Function for SLCO2A1 Gene

Molecular function for SLCO2A1 Gene

UniProtKB/Swiss-Prot Function:
May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

Phenotypes From GWAS Catalog for SLCO2A1 Gene

Gene Ontology (GO) - Molecular Function for SLCO2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005319 lipid transporter activity TAS 8787677
GO:0015132 prostaglandin transmembrane transporter activity IEA,TAS --
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLCO2A1: view
genes like me logo Genes that share phenotypes with SLCO2A1: view

Human Phenotype Ontology for SLCO2A1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLCO2A1 Gene

MGI Knock Outs for SLCO2A1:

Animal Model Products

miRNA for SLCO2A1 Gene

miRTarBase miRNAs that target SLCO2A1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLCO2A1 Gene

Localization for SLCO2A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO2A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLCO2A1 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLCO2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 8787677
GO:0016020 membrane IEA,TAS 8787677
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLCO2A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLCO2A1 Gene

Pathways & Interactions for SLCO2A1 Gene

genes like me logo Genes that share pathways with SLCO2A1: view

Interacting Proteins for SLCO2A1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000311291%0d%0a9606.ENSP00000311032%0d%0a9606.ENSP00000352516%0d%0a9606.ENSP00000310040%0d%0a9606.ENSP00000351250%0d%0a9606.ENSP00000276893%0d%0a
Selected Interacting proteins: Q92959-SO2A1_HUMAN ENSP00000311291 for SLCO2A1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SLCO2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006869 lipid transport TAS 8787677
GO:0015732 prostaglandin transport IEA --
GO:0043252 sodium-independent organic anion transport TAS --
genes like me logo Genes that share ontologies with SLCO2A1: view

No data available for SIGNOR curated interactions for SLCO2A1 Gene

Drugs & Compounds for SLCO2A1 Gene

(17) Drugs for SLCO2A1 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Furosemide Approved, Vet_approved Pharma Agonist, Transporter, inhibitor GABAA receptors antagonist, Na+/2Cl-/K+ (NKCC) symporter inhibitor. Also antagonizes GABAA 209
Iloprost Approved, Investigational Pharma Full agonist, Agonist, Transporter, substrate Prostacyclin (PGI2) analog, Others 83
Pyruvic acid Approved, Investigational Nutra Transporter, inhibitor 0
Alprostadil Approved, Investigational Pharma Transporter, substrate 71
Dinoprost Tromethamine Approved, Vet_approved Pharma Transporter 12

(8) Additional Compounds for SLCO2A1 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
bromocresol green
Inhibition, Inhibitor
BSP
Inhibition, Inhibitor
genes like me logo Genes that share compounds with SLCO2A1: view

Transcripts for SLCO2A1 Gene

Unigene Clusters for SLCO2A1 Gene

Solute carrier organic anion transporter family, member 2A1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO2A1 Gene

No ASD Table

Relevant External Links for SLCO2A1 Gene

GeneLoc Exon Structure for
SLCO2A1
ECgene alternative splicing isoforms for
SLCO2A1

Expression for SLCO2A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLCO2A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO2A1 Gene

This gene is overexpressed in Lung (x6.6) and Thyroid (x4.6).

Protein differential expression in normal tissues from HIPED for SLCO2A1 Gene

This gene is overexpressed in Adrenal (26.5), Seminal vesicle (7.2), Placenta (6.7), Lung (6.6), and Uterus (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLCO2A1 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLCO2A1 Gene:

SLCO2A1

SOURCE GeneReport for Unigene cluster for SLCO2A1 Gene:

Hs.518270

mRNA Expression by UniProt/SwissProt for SLCO2A1 Gene:

Q92959-SO2A1_HUMAN
Tissue specificity: Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart.

Evidence on tissue expression from TISSUES for SLCO2A1 Gene

  • Nervous system(4.2)
  • Pancreas(2.8)
  • Skin(2.6)
  • Kidney(2.3)
  • Lung(2.2)
  • Thyroid gland(2.1)
  • Intestine(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SLCO2A1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • scalp
  • skull
Thorax:
  • chest wall
  • clavicle
  • heart
  • rib
  • rib cage
  • scapula
  • sternum
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • hair
  • skin
  • spinal column
  • sweat gland
  • vertebrae
genes like me logo Genes that share expression patterns with SLCO2A1: view

No data available for Protein tissue co-expression partners for SLCO2A1 Gene

Orthologs for SLCO2A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLCO2A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLCO2A1 33 34
  • 94.61 (n)
dog
(Canis familiaris)
Mammalia SLCO2A1 33 34
  • 88.85 (n)
cow
(Bos Taurus)
Mammalia SLCO2A1 33 34
  • 86.16 (n)
mouse
(Mus musculus)
Mammalia Slco2a1 33 16 34
  • 84.84 (n)
rat
(Rattus norvegicus)
Mammalia Slco2a1 33
  • 84.48 (n)
oppossum
(Monodelphis domestica)
Mammalia SLCO2A1 34
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLCO2A1 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLCO2A1 33 34
  • 71.41 (n)
lizard
(Anolis carolinensis)
Reptilia SLCO2A1 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slco2a1 33
  • 64.25 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68657 33
zebrafish
(Danio rerio)
Actinopterygii slco2a1 34
  • 55 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
OneToMany
Species where no ortholog for SLCO2A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLCO2A1 Gene

ENSEMBL:
Gene Tree for SLCO2A1 (if available)
TreeFam:
Gene Tree for SLCO2A1 (if available)

Paralogs for SLCO2A1 Gene

(15) SIMAP similar genes for SLCO2A1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLCO2A1: view

Variants for SLCO2A1 Gene

Sequence variations from dbSNP and Humsavar for SLCO2A1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1085307096 likely-pathogenic, Primary hypertrophic osteoarthropathy, autosomal recessive 2 133,947,261(-) GGGGTAGACTTCGG/GG coding_sequence_variant, inframe_deletion
rs370769816 uncertain-significance, Variant of unknown significance 133,951,315(-) G/A coding_sequence_variant, stop_gained
rs387906806 pathogenic, Primary hypertrophic osteoarthropathy, autosomal recessive 2, Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2) [MIM:614441] 133,951,305(-) C/T coding_sequence_variant, missense_variant
rs387907295 pathogenic, Primary hypertrophic osteoarthropathy, autosomal recessive 2, Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2) [MIM:614441] 133,947,292(-) C/A coding_sequence_variant, missense_variant
rs387907296 pathogenic, Primary hypertrophic osteoarthropathy, autosomal recessive 2, Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2) [MIM:614441] 133,973,807(-) T/A/C 5_prime_UTR_variant, coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO2A1 Gene

Variant ID Type Subtype PubMed ID
esv1546500 CNV deletion 17803354
esv2222789 CNV deletion 18987734
esv2725944 CNV deletion 23290073
esv2725945 CNV deletion 23290073
nsv1147308 CNV deletion 26484159
nsv472400 CNV novel sequence insertion 20440878
nsv527655 CNV loss 19592680

Variation tolerance for SLCO2A1 Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.12; 84.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLCO2A1 Gene

Human Gene Mutation Database (HGMD)
SLCO2A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLCO2A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO2A1 Gene

Disorders for SLCO2A1 Gene

MalaCards: The human disease database

(12) MalaCards diseases for SLCO2A1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypertrophic osteoarthropathy, primary, autosomal recessive, 2
  • phoar2
chronic enteropathy associated with slco2a1 gene
  • ceas
primary hypertrophic osteoarthropathy
  • pachydermoperiostosis of nail
secondary hypertrophic osteoarthropathy
  • bamberger-marie disease
neurogenic arthropathy
  • arthropathy associated with neurological disorder
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

SO2A1_HUMAN
  • Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2) [MIM:614441]: A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. {ECO:0000269 PubMed:22197487, ECO:0000269 PubMed:22331663, ECO:0000269 PubMed:22553128, ECO:0000269 PubMed:22696055}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for SLCO2A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLCO2A1: view

No data available for Genatlas for SLCO2A1 Gene

Publications for SLCO2A1 Gene

  1. Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT). (PMID: 8787677) Lu R … Schuster VL (The Journal of clinical investigation 1996) 2 3 4 22 25 58
  2. Molecular cloning of the gene for the human prostaglandin transporter hPGT: gene organization, promoter activity, and chromosomal localization. (PMID: 9618293) Lu R … Schuster VL (Biochemical and biophysical research communications 1998) 2 3 4 58
  3. Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy. (PMID: 22197487) Zhang Z … Liu Y (American journal of human genetics 2012) 3 4 58
  4. Mutations in the prostaglandin transporter encoding gene SLCO2A1 cause primary hypertrophic osteoarthropathy and isolated digital clubbing. (PMID: 22331663) Seifert W … Horn D (Human mutation 2012) 3 4 58
  5. Prostaglandin transporter mutations cause pachydermoperiostosis with myelofibrosis. (PMID: 22553128) Diggle CP … Bonthron DT (Human mutation 2012) 3 4 58

Products for SLCO2A1 Gene

Sources for SLCO2A1 Gene

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