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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLCO2A1 Gene

protein-coding   GIFtS: 61
GCID: GC03M133651

Solute Carrier Organic Anion Transporter Family, Member...

(Previous names: solute carrier family 21 (prostaglandin transporter), member...)
(Previous symbols: SLC21A2, MATR1)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Organic Anion Transporter Family, Member 2A11 2     Prostaglandin Transporter2 3
SLC21A21 2 3 5     Solute Carrier Family 21 Member 22 3
PGT2 3 5     OATP2A12 3
MATR11 2     PHOAR22
Matrin F/G 11 2     Solute Carrier Organic Anion Transporter Family Member 2A12
Solute Carrier Family 21 (Prostaglandin Transporter), Member 21 2     

External Ids:    HGNC: 109551   Entrez Gene: 65782   Ensembl: ENSG000001746407   OMIM: 6014605   UniProtKB: Q929593   

Export aliases for SLCO2A1 gene to outside databases

Previous GC identifers: GC03M134972 GC03M135134 GC03M131029


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLCO2A1 Gene:
This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of
transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in
numerous tissues. (provided by RefSeq, Dec 2011)

GeneCards Summary for SLCO2A1 Gene: 
SLCO2A1 (solute carrier organic anion transporter family, member 2A1) is a protein-coding gene. Diseases associated with SLCO2A1 include primary hypertrophic osteoarthropathy, and secondary hypertrophic osteoarthropathy, and among its related super-pathways are Transmembrane transport of small molecules and Transport of vitamins, nucleosides, and related molecules. GO annotations related to this gene include prostaglandin transmembrane transporter activity and lipid transporter activity. An important paralog of this gene is SLCO4C1.

UniProtKB/Swiss-Prot: SO2A1_HUMAN, Q92959
Function: May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of
prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2
and PGF2A

Gene Wiki entry for SLCO2A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLCO2A1 gene promoter:
         STAT1   NF-1   NF-1/L   STAT1beta   CUTL1   Cdc5   STAT1alpha   GATA-1   AREB6   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLCO2A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLCO2A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLCO2A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21   Ensembl cytogenetic band:  3q22.2   HGNC cytogenetic band: 3q21

SLCO2A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO2A1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M133651:  view genomic region     (about GC identifiers)

Start:
133,651,540 bp from pter      End:
133,771,028 bp from pter
Size:
119,489 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SO2A1_HUMAN, Q92959 (See protein sequence)
Recommended Name: Solute carrier organic anion transporter family member 2A1  
Size: 643 amino acids; 70044 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for SLCO2A1:
3MRR (3D)    
Secondary accessions: Q86V98 Q8IUN2

Explore the universe of human proteins at neXtProt for SLCO2A1: NX_Q92959

Explore proteomics data for SLCO2A1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92959

  • SLCO2A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLCO2A1 Protein Expression
    REFSEQ proteins: NP_005621.2  
    ENSEMBL proteins: 
     ENSP00000311291   ENSP00000418893   ENSP00000420028  
    Reactome Protein details: Q92959
    Human Recombinant Protein Products for SLCO2A1: 
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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8787677
    GO:0016020membrane TAS8787677
    GO:0016021integral to membrane ----

    SLCO2A1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: OATP2A1 
    SLCO family of organic anion transporting polypeptides

    4 InterPro protein domains:
     IPR002350 Kazal_dom
     IPR004156 OA_transporter
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q92959

    ProtoNet protein and cluster: Q92959

    2 Blocks protein domains:
    IPB004156 Organic anion transporter polypeptide (OATP)
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: SO2A1_HUMAN, Q92959
    Similarity: Belongs to the organo anion transporter (TC 2.A.60) family
    Similarity: Contains 1 Kazal-like domain


    SLCO2A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SO2A1_HUMAN, Q92959
    Function: May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of
    prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2
    and PGF2A

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005319lipid transporter activity TAS8787677
    GO:0005515protein binding ----
    GO:0015132prostaglandin transmembrane transporter activity IEA--
         
    SLCO2A1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SLCO2A1:
     Decreased cell number  G0/1 arrest  Lamellipodia cells 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slco2a1):
     cardiovascular system  cellular  homeostasis/metabolism  mortality/aging  renal/urinary system 

    SLCO2A1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slco2a1tm1.2Vsch for SLCO2A1

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLCO2A1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50
    2Transport of organic anions
    Transport of vitamins, nucleosides, and related molecules0.34
    Transport of organic anions0.34
    3PKA activation in glucagon signalling
    Neurophysiological process PGE2-induced pain processing0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SLCO2A1
        Neurophysiological process PGE2-induced pain processing


    1 GeneGo (Thomson Reuters) Pathway for SLCO2A1
        Neurophysiological process PGE2-induced pain processing

    4        Reactome Pathways for SLCO2A1
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of vitamins, nucleosides, and related molecules
    Transport of organic anions



    SLCO2A1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLCO2A1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLCO2A1 (Q929591, 3 ENSP000003112914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 3, ENSP000003390074EBI-1760532,EBI-401755 I2D: score=1 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006869lipid transport TAS8787677
    GO:0015732prostaglandin transport ----
    GO:0043252sodium-independent organic anion transport TAS--
    GO:0055085transmembrane transport TAS--

    SLCO2A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLCO2A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SLCO2A1 (SO2A1)

    10/13 DrugBank Compounds for SLCO2A1 (see all 13)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alprostadil-- 745-65-3transportersubstrate8787677 7754369
    DinoprostoneDinoprostone Prostaglandin E2 (see all 3)363-24-6transportersubstrate8787677 7754369
    Iloprost-- 78919-13-8transportersubstrate8787677 7754369
    Arachidonic Acid-- 506-32-1transportersubstrate7754369
    Dinoprost TromethamineDinoprost, trometamol salt (see all 7)38562-01-5transporter--8787677
    Fructose-1,6-Diphosphate-- --transporterinhibitor11997326
    FurosemideDihydroflumethiazide (see all 12)54-31-9transporterinhibitor7754369
    Glucose-6-Phosphate-- 56-73-5transporterinhibitor11997326
    Glyceraldehyde-3-Phosphate-- 142-10-9transporterinhibitor11997326
    Lactic Acid-- 50-21-5transporterinhibitor11997326

    3 IUPHAR Ligands for SLCO2A1 (OATP2A1)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [3H]PGE2
    NoneNone--
    BSP
    InhibitorInhibition--
    bromocresol green
    InhibitorInhibition--

    8 Novoseek inferred chemical compound relationships for SLCO2A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostaglandin 84.1 55 15044627 (3), 15657371 (2), 16842938 (2), 14631946 (2) (see all 29)
    (+-)-pgf2-alpha 77.4 2 15044627 (1)
    oatp 70.2 2 10601278 (1)
    pge2 63.6 11 15044627 (3), 14631946 (1), 19138942 (1), 9506966 (1)
    prostaglandin f2alpha 58.1 1 11093791 (1)
    pge1 38.4 1 14631946 (1)
    indomethacin 29.3 1 12630701 (1)
    atp 0 1 12630701 (1)

    Search CenterWatch for drugs/clinical trials and news about SLCO2A1 / SO2A1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLCO2A1 gene: 
    NM_005630.2  

    Unigene Cluster for SLCO2A1:

    Solute carrier organic anion transporter family, member 2A1
    Hs.518270  [show with all ESTs]
    Unigene Representative Sequence: NM_005630
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310926(uc003eqa.4) ENST00000493729 ENST00000481359 ENST00000462770(uc011blv.2)
    ENST00000477061 ENST00000464676(uc010htw.1) ENST00000478651 ENST00000478662


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    Additional mRNA sequence: 

    AK303550.1 AK309561.1 BC041140.1 BC051347.1 U70867.1 

    8 DOTS entries:

    DT.314904  DT.95229652  DT.100748492  DT.120894286  DT.120894293  DT.70101265  DT.91690159  DT.91747746 

    24/143 AceView cDNA sequences (see all 143):

    AW583761 BM504792 BM127485 BC051347 AI200637 BM312407 BG055100 BM672624 
    AW304821 AA913860 BF446356 AI474048 BU741978 BQ102463 BQ272209 BQ881236 
    BM710461 AA369951 AI376659 BM352304 BU502767 AI492517 BF111670 BM725078 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLCO2A1 expression in normal human tissues (normalized intensities)      SLCO2A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAATTTAAC
    SLCO2A1 Expression
    About this image


    SLCO2A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Kidney (Urinary System)    fully expand to see all 7 entries
             Podocytes Podocyte Layer
             Proximal Tubule
             visceral organ/metanephros/renal cortex   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ/metanephros/renal cortex   
     
     Primitive Streak (Early Embryonic Tissues)
             Definitive endoderm-like cells ( Generation and expansion of endodermal progenitor...
     
     Gut Tube (Gastrointestinal Tract)
             Endoderm progenitor-like cells ( Generation and expansion of endodermal progenitor...
     
     Uterus (Reproductive System)
             myometrium   

    See SLCO2A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLCO2A1

    SOURCE GeneReport for Unigene cluster: Hs.518270

    UniProtKB/Swiss-Prot: SO2A1_HUMAN, Q92959
    Tissue specificity: Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart

        SABiosciences Expression via Pathway-Focused PCR Array including SLCO2A1: 
              Drug Transporters in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLCO2A1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slco2a11 , 5 solute carrier organic anion transporter family, member more1, 5 84.84(n)1
    83.33(a)1
      9 (54.72 cM)5
    240591  NM_033314.31  NP_201571.21 
     1030084895 
    chicken
    (Gallus gallus)
    Aves SLCO2A11 solute carrier organic anion transporter family, member more 71.41(n)
    66.77(a)
      424862  NM_001198927.1  NP_001185856.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLCO2A16
    solute carrier organic anion transporter family, m...
    51(a)
    1 ↔ 1
    3(31013525-31165221)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686572 hypothetical protein MGC68657 75.05(n)    BC060473.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slco2a16
    solute carrier organic anion transporter family, m...
    54(a)
    1 ↔ 1
    6(27332251-27373486)
    fruit fly
    (Drosophila melanogaster)
    Insecta Oatp33Ea6
    Oatp58Da6
    (see all 6)
    Organic anion transporting polypeptide 58Da
    (see all 6)
    22(a)
    22(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    2L(12441401-12445924)
    2R(18105961-18108393)
    worm
    (Caenorhabditis elegans)
    Secernentea F21G4.16
    Y32F6B.16
    (see all 4)
    Protein Y32F6B.1
    (see all 4)
    25(a)
    20(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    X(9889315-9892328)
    V(10480946-10484740)


    ENSEMBL Gene Tree for SLCO2A1 (if available)
    TreeFam Gene Tree for SLCO2A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLCO2A1 gene
    SLCO4C12  SLCO1B72  ENSG000002570622  SLCO1B32  SLCO3A12  SLCO2B12  SLCO5A12  SLCO1B12  
    SLCO6A12  SLCO1A22  SLCO1C12  ENSG000002570462  SLCO4A12  
    15 SIMAP similar genes for SLCO2A1 using alignment to 3 protein entries:     SO2A1_HUMAN (see all proteins):
    SLC21A2    SLCO2B1    SLCO1A2    SLCO1B3    SLCO1B1    SLCO4A1
    SLCO4C1    SLCO3A1    SLCO5A1    LST3    SLCO1B7    SLCO6A1
    SPINK7    SLC21A8    SLCO1C1

    SLCO2A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2206 SNPs in SLCO2A1 are shown (see all 2206)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0686414
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4--see VAR_0686412 G R mis40--------
    VAR_0686384
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4--see VAR_0686382 G A mis40--------
    VAR_0683524
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4--see VAR_0683522 F S mis40--------
    VAR_0686404
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4--see VAR_0686402 S L mis40--------
    VAR_0686424
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4--see VAR_0686422 C F mis40--------
    VAR_0686394
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4--see VAR_0686392 G D mis40--------
    VAR_0686454
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4--see VAR_0686452 W G mis40--------
    VAR_0675994
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4--see VAR_0675992 G E mis40--------
    VAR_0686374
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4--see VAR_0686372 R H mis40--------
    VAR_0686444
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4--see VAR_0686442 Q H mis40--------

    HapMap Linkage Disequilibrium report for SLCO2A1 (133651540 - 133771028 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SLCO2A1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2725945CNV Deletion23290073
    esv1546500CNV Deletion17803354
    esv2725944CNV Deletion23290073
    esv2222789CNV Deletion18987734
    nsv527655CNV Loss19592680
    nsv877509CNV Gain21882294


    Human Gene Mutation Database (HGMD): SLCO2A1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLCO2A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLCO2A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601460    OMIM disorders: --

    UniProtKB/Swiss-Prot: SO2A1_HUMAN, Q92959
  • Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2) [MIM:614441]: A disease
    characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features
    of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include
    delayed closure of the cranial sutures and congenital heart disease. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 11 diseases for SLCO2A1:    About MalaCards
    primary hypertrophic osteoarthropathy    secondary hypertrophic osteoarthropathy    gastroduodenitis    myelofibrosis
    hyperparathyroidism    choroiditis    ischemia    colon cancer
    endotheliitis    alzheimer's disease    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for SLCO2A1:
    Primary hypertrophic osteoarthropathy     Secondary hypertrophic osteoarthropathy

    SLCO2A1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): SLCO2A1
    Human Genome Epidemiology (HuGE) Navigator: SLCO2A1 (3 documents)

    Export disorders for SLCO2A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLCO2A1 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with SLCO2A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT). (PubMed id 8787677)1, 2, 3, 7, 9 Lu R.... Schuster V.L. (1996)
    2. Molecular cloning of the gene for the human prostaglandin transporter hPGT: gene organization, promoter activity, and chromosomal localization. (PubMed id 9618293)1, 2, 3 Lu R. and Schuster V.L. (1998)
    3. Mutations in the prostaglandin transporter SLCO2A1 cause primary hypertrophic osteoarthropathy with digital clubbing. (PubMed id 22696055)1, 2 Busch J.... Bergmann C. (2012)
    4. Mutations in the prostaglandin transporter encoding gene SLCO2A1 cause primary hypertrophic osteoarthropathy and isolated digital clubbing. (PubMed id 22331663)1, 2 Seifert W.... Horn D. (2012)
    5. Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy. (PubMed id 22197487)1, 2 Zhang Z.... Liu Y. (2012)
    6. Prostaglandin transporter mutations cause pachydermoperiostosis with myelofibrosis. (PubMed id 22553128)1, 2 Diggle C.P.... Bonthron D.T. (2012)
    7. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (2010)
    8. Genetic factors related to unconjugated hyperbilirubinemia amongst adults. (PubMed id 15864125)1, 4 Huang C.S....Tang K.S. (2005)
    9. Regulation of prostaglandin transporters in colorectal neoplasia. (PubMed id 19138942)1, 9 Holla V.R....DuBois R.N. (2008)
    10. Expression and localization of prostaglandin transporter in Alzheimer disease brains and age-matched controls. (PubMed id 18353443)1, 9 Choi K....Dore S. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6578 HGNC: 10955 AceView: SLCO2A1 Ensembl:ENSG00000174640 euGenes: HUgn6578
    ECgene: SLCO2A1 H-InvDB: SLCO2A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLCO2A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLCO2A1 gene:
    Search GeneIP for patents involving SLCO2A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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