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Aliases for SLCO2A1 Gene

Aliases for SLCO2A1 Gene

  • Solute Carrier Organic Anion Transporter Family, Member 2A1 2 3
  • Solute Carrier Family 21 (Prostaglandin Transporter), Member 2 2 3
  • Matrin F/G 1 2 3
  • SLC21A2 3 4
  • OATP2A1 3 4
  • PGT 3 4
  • Solute Carrier Family 21 Member 2 4
  • Prostaglandin Transporter 4
  • PHOAR2 3
  • MATR1 3

External Ids for SLCO2A1 Gene

Previous HGNC Symbols for SLCO2A1 Gene

  • SLC21A2
  • MATR1

Previous GeneCards Identifiers for SLCO2A1 Gene

  • GC03M134972
  • GC03M135134
  • GC03M133651
  • GC03M131029

Summaries for SLCO2A1 Gene

Entrez Gene Summary for SLCO2A1 Gene

  • This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011]

GeneCards Summary for SLCO2A1 Gene

SLCO2A1 (Solute Carrier Organic Anion Transporter Family, Member 2A1) is a Protein Coding gene. Diseases associated with SLCO2A1 include hypertrophic osteoarthropathy, primary, autosomal recessive 2 and neurogenic arthropathy. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and DAG and IP3 signaling. GO annotations related to this gene include transporter activity and prostaglandin transmembrane transporter activity. An important paralog of this gene is SLCO1B7.

UniProtKB/Swiss-Prot for SLCO2A1 Gene

  • May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A

Gene Wiki entry for SLCO2A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO2A1 Gene

Genomics for SLCO2A1 Gene

Regulatory Elements for SLCO2A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLCO2A1 Gene

Chromosome:
3
Start:
133,932,696 bp from pter
End:
134,052,184 bp from pter
Size:
119,489 bases
Orientation:
Minus strand

Genomic View for SLCO2A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLCO2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO2A1 Gene

Proteins for SLCO2A1 Gene

  • Protein details for SLCO2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92959-SO2A1_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 2A1
    Protein Accession:
    Q92959
    Secondary Accessions:
    • Q86V98
    • Q8IUN2

    Protein attributes for SLCO2A1 Gene

    Size:
    643 amino acids
    Molecular mass:
    70044 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SLCO2A1 Gene

neXtProt entry for SLCO2A1 Gene

Proteomics data for SLCO2A1 Gene at MOPED

Post-translational modifications for SLCO2A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLCO2A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLCO2A1 Gene

Domains & Families for SLCO2A1 Gene

Gene Families for SLCO2A1 Gene

Suggested Antigen Peptide Sequences for SLCO2A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92959

UniProtKB/Swiss-Prot:

SO2A1_HUMAN :
  • Contains 1 Kazal-like domain.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
Domain:
  • Contains 1 Kazal-like domain.
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO2A1: view

Function for SLCO2A1 Gene

Molecular function for SLCO2A1 Gene

UniProtKB/Swiss-Prot Function:
May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A

Gene Ontology (GO) - Molecular Function for SLCO2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005319 lipid transporter activity TAS 8787677
GO:0005515 protein binding --
GO:0015132 prostaglandin transmembrane transporter activity IBA --
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLCO2A1: view
genes like me logo Genes that share phenotypes with SLCO2A1: view

Animal Models for SLCO2A1 Gene

MGI Knock Outs for SLCO2A1:

Animal Model Products

CRISPR Products

miRNA for SLCO2A1 Gene

miRTarBase miRNAs that target SLCO2A1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLCO2A1 Gene

Localization for SLCO2A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO2A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLCO2A1 Gene COMPARTMENTS Subcellular localization image for SLCO2A1 gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SLCO2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8787677
GO:0016020 membrane TAS 8787677
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLCO2A1: view

Pathways & Interactions for SLCO2A1 Gene

genes like me logo Genes that share pathways with SLCO2A1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SLCO2A1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000311291%0d%0a9606.ENSP00000339007%0d%0a
Selected Interacting proteins: Q92959-SO2A1_HUMAN ENSP00000311291 for SLCO2A1 Gene via UniProtKB I2D STRING

Gene Ontology (GO) - Biological Process for SLCO2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport --
GO:0006869 lipid transport TAS 8787677
GO:0015732 prostaglandin transport IBA --
GO:0043252 sodium-independent organic anion transport TAS --
genes like me logo Genes that share ontologies with SLCO2A1: view

No data available for SIGNOR curated interactions for SLCO2A1 Gene

Drugs & Compounds for SLCO2A1 Gene

(16) Drugs for SLCO2A1 Gene - From: NovoSeek, IUPHAR, DGIdb, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Furosemide Approved Pharma Inhibition, Inhibitor, Transporter, inhibitor GABAA receptors antagonist, Na+/2Cl-/K+ (NKCC) cotransporter inhibitor. Also antagonizes GABAA 158
Iloprost Approved, Investigational Pharma Full agonist, Agonist, Transporter, substrate Others, Prostacyclin (PGI2) analog 73
Pyruvic acid Approved Nutra Transporter, inhibitor 0
Alprostadil Approved, Investigational Pharma Transporter, substrate 57
Dinoprost Tromethamine Approved Pharma Transporter 9

(8) Additional Compounds for SLCO2A1 Gene - From: IUPHAR and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
bromocresol green
Inhibition, Inhibitor
BSP
Inhibition, Inhibitor
(+-)-pgf2-alpha
oATP
PGE1
genes like me logo Genes that share compounds with SLCO2A1: view

Transcripts for SLCO2A1 Gene

Unigene Clusters for SLCO2A1 Gene

Solute carrier organic anion transporter family, member 2A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO2A1 Gene

No ASD Table

Relevant External Links for SLCO2A1 Gene

GeneLoc Exon Structure for
SLCO2A1
ECgene alternative splicing isoforms for
SLCO2A1

Expression for SLCO2A1 Gene

mRNA expression in normal human tissues for SLCO2A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO2A1 Gene

This gene is overexpressed in Lung (x6.6) and Thyroid (x4.6).

Protein differential expression in normal tissues from HIPED for SLCO2A1 Gene

This gene is overexpressed in Adrenal (26.5), Seminal vesicle (7.2), Placenta (6.7), Lung (6.6), and Uterus (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLCO2A1 Gene



SOURCE GeneReport for Unigene cluster for SLCO2A1 Gene Hs.518270

mRNA Expression by UniProt/SwissProt for SLCO2A1 Gene

Q92959-SO2A1_HUMAN
Tissue specificity: Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart.
genes like me logo Genes that share expression patterns with SLCO2A1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for SLCO2A1 Gene

Orthologs for SLCO2A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLCO2A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLCO2A1 35
  • 86.16 (n)
  • 83.83 (a)
SLCO2A1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLCO2A1 35
  • 88.85 (n)
  • 89.11 (a)
SLCO2A1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slco2a1 35
  • 84.84 (n)
  • 83.33 (a)
Slco2a1 16
Slco2a1 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLCO2A1 35
  • 94.61 (n)
  • 93.93 (a)
SLCO2A1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slco2a1 35
  • 84.48 (n)
  • 83.02 (a)
oppossum
(Monodelphis domestica)
Mammalia SLCO2A1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLCO2A1 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLCO2A1 35
  • 71.41 (n)
  • 66.77 (a)
SLCO2A1 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLCO2A1 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slco2a1 35
  • 64.25 (n)
  • 66.78 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68657 35
zebrafish
(Danio rerio)
Actinopterygii slco2a1 36
  • 55 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for SLCO2A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLCO2A1 Gene

ENSEMBL:
Gene Tree for SLCO2A1 (if available)
TreeFam:
Gene Tree for SLCO2A1 (if available)

Paralogs for SLCO2A1 Gene

(15) SIMAP similar genes for SLCO2A1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLCO2A1: view

Variants for SLCO2A1 Gene

Sequence variations from dbSNP and Humsavar for SLCO2A1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1131597 -- 133,933,562(-) GGTGG(A/G)TGCCT utr-variant-3-prime
rs1131598 -- 133,933,478(-) AATAT(A/G)TTTAT utr-variant-3-prime
rs2075697 -- 133,933,504(-) CCAAC(A/G)AAGGA utr-variant-3-prime
rs2370512 -- 133,933,896(-) TGAAA(A/T)GGTCC utr-variant-3-prime
rs3923834 -- 133,942,508(-) TCCCC(A/C/T)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO2A1 Gene

Variant ID Type Subtype PubMed ID
esv2725944 CNV Deletion 23290073
esv2222789 CNV Deletion 18987734
esv2725945 CNV Deletion 23290073
esv1546500 CNV Deletion 17803354
nsv527655 CNV Loss 19592680
nsv877509 CNV Gain 21882294

Variation tolerance for SLCO2A1 Gene

Residual Variation Intolerance Score: 92.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.12; 84.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLCO2A1 Gene

HapMap Linkage Disequilibrium report
SLCO2A1
Human Gene Mutation Database (HGMD)
SLCO2A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO2A1 Gene

Disorders for SLCO2A1 Gene

MalaCards: The human disease database

(12) MalaCards diseases for SLCO2A1 Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypertrophic osteoarthropathy, primary, autosomal recessive 2
  • pachydermoperiostosis, autosomal recessive
neurogenic arthropathy
  • arthropathy associated with neurological disorder
secondary hypertrophic osteoarthropathy
  • hypertrophic pulmonary osteoarthropathy
primary hypertrophic osteoarthropathy
  • pachydermoperiostosis of nail
gastric mucosal hypertrophy
  • hypertrophic gastropathy
- elite association

UniProtKB/Swiss-Prot

SO2A1_HUMAN
  • Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2) [MIM:614441]: A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. {ECO:0000269 PubMed:22197487, ECO:0000269 PubMed:22331663, ECO:0000269 PubMed:22553128, ECO:0000269 PubMed:22696055}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLCO2A1

Genetic Association Database (GAD)
SLCO2A1
Human Genome Epidemiology (HuGE) Navigator
SLCO2A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLCO2A1
genes like me logo Genes that share disorders with SLCO2A1: view

No data available for Genatlas for SLCO2A1 Gene

Publications for SLCO2A1 Gene

  1. Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT). (PMID: 8787677) Lu R. … Schuster V.L. (J. Clin. Invest. 1996) 2 23 25 26 67
  2. Regulation and role of organic anion-transporting polypeptides (OATPs) in drug delivery at the choroid plexus. (PMID: 20356750) Zhang H. … Yu L.G. (J Clin Neurosci 2010) 23 67
  3. Influence of cyclooxygenase inhibitors on the function of the prostaglandin transporter organic anion-transporting polypeptide 2A1 expressed in human gastroduodenal mucosa. (PMID: 19843975) Mandery K. … Glaeser H. (J. Pharmacol. Exp. Ther. 2010) 23 67
  4. The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. (PMID: 19136477) Greenhough A. … Kaidi A. (Carcinogenesis 2009) 23 67
  5. Molecular cloning and characterization of the porcine prostaglandin transporter (SLCO2A1): evaluation of its role in F4 mediated neonatal diarrhoea. (PMID: 19807916) Van Poucke M. … Peelman L.J. (BMC Genet. 2009) 23 67

Products for SLCO2A1 Gene

Sources for SLCO2A1 Gene

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