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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLCO2A1 Gene

protein-coding   GIFtS: 61
GCID: GC03M133651

solute carrier organic anion transporter family, member...

(Previous names: solute carrier family 21 (prostaglandin transporter), member...)
(Previous symbols: SLC21A2, MATR1)
 Explore 8 diseases affiliated with
SLCO2A1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLCO2A1    

Aliases
for SLCO2A1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Organic Anion Transporter Family, Member 2A11 2     Solute Carrier Family 21 (Prostaglandin Transporter), Member 21 2
PGT1 2 3 5     Prostaglandin Transporter2 3
SLC21A21 2 3 5     Solute Carrier Family 21 Member 22 3
OATP2A11 2 3     PHOAR22
MATR11 2     Solute Carrier Organic Anion Transporter Family Member 2A12
Matrin F/G 11 2     

External Ids:    HGNC: 109551   Entrez Gene: 65782   Ensembl: ENSG000001746407   OMIM: 6014605   UniProtKB: Q929593   

Export aliases for SLCO2A1 gene to outside databases

Previous GC identifers: GC03M134972 GC03M135134 GC03M131029


Summaries
for SLCO2A1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLCO2A1:
This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters.
The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues.
(provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: SO2A1_HUMAN, Q92959
Function: May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of
prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and
PGF2A

Gene Wiki entry for SLCO2A1


Genomic Views
for SLCO2A1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLCO2A1 gene promoter:
         STAT1   NF-1   NF-1/L   STAT1beta   CUTL1   Cdc5   STAT1alpha   GATA-1   AREB6   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLCO2A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLCO2A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLCO2A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21   Ensembl cytogenetic band:  3q22.2   HGNC cytogenetic band: 3q21

SLCO2A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO2A1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M133651:  view genomic region     (about GC identifiers)

Start:
 133,651,540 bp from pter      End:
 133,771,028 bp from pter
Size:
 119,489 bases      Orientation:
 minus strand

Proteins
for SLCO2A1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SO2A1_HUMAN, Q92959 (See protein sequence)
Recommended Name: Solute carrier organic anion transporter family member 2A1  
Size: 643 amino acids; 70044 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for SLCO2A1:
3MRR (3D)    
Secondary accessions: Q86V98 Q8IUN2

Explore the universe of human proteins at neXtProt for SLCO2A1: NX_Q92959

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92959

    • SLCO2A1 Protein expression data from MOPED and PaxDb:    About this image 
    SLCO2A1 Protein Expression
    REFSEQ proteins: NP_005621.2  
    ENSEMBL proteins: 
     ENSP00000311291   ENSP00000418893   ENSP00000420028  
    Reactome Protein details: Q92959
    Human Recombinant Protein Products for SLCO2A1: 
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    Uscn Proteins for SLCO2A1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8787677
    GO:0016020membrane TAS8787677

    SLCO2A1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SLCO2A1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLCO2A1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR002350 Prot_inh_Kazal
     IPR004156 OA_transporter
     IPR020846 MFS_dom
     IPR011497 Kazal-type_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q92959

    ProtoNet protein and cluster: Q92959

    2 Blocks protein families:
    IPB004156 Organic anion transporter polypeptide (OATP)
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: SO2A1_HUMAN, Q92959
    Similarity: Belongs to the organo anion transporter (TC 2.A.60) family
    Similarity: Contains 1 Kazal-like domain


    Function
    for SLCO2A1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SO2A1_HUMAN, Q92959
    Function: May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of
    prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and
    PGF2A

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005319lipid transporter activity TAS8787677
    GO:0015132prostaglandin transmembrane transporter activity IEA--
         
    SLCO2A1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SLCO2A1:
     Decreased cell number  G0/1 arrest  Lamellipodia cells 

         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Slco2a1):
     cardiovascular system  cellular  homeostasis/metabolism  mortality/aging  renal/urinary system 

    SLCO2A1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Slco2a1tm1.2Vsch for SLCO2A1
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    miRNA
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    hsa-miR-548p hsa-miR-125a-5p hsa-miR-3607-5p hsa-miR-3184 hsa-miR-4251 hsa-miR-1224-3p hsa-miR-4299 hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmid: SLCO2A1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Cell Line
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    In Situ Assay
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    Pathways & Interactions
    for SLCO2A1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transport of organic anions
    		Transport of organic anions1.00
    		Transport of vitamins, nucleosides, and related molecules0.35
    2SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50
    3PKA activation in glucagon signalling
    		Neurophysiological process_PGE2-induced pain processing0.44
    		Neurophysiological process PGE2-induced pain processing0.44

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SLCO2A1
        Neurophysiological process PGE2-induced pain processing


    1 GeneGo (Thomson Reuters) Pathway for SLCO2A1
        Neurophysiological process PGE2-induced pain processing

    4        Reactome Pathways for SLCO2A1
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of vitamins, nucleosides, and related molecules
    Transport of organic anions



    SLCO2A1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLCO2A1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLCO2A1 (Q929591, 3 ENSP000003112914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 3, ENSP000003390074EBI-1760532,EBI-401755 I2D: score=1 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006869lipid transport TAS8787677
    GO:0015732prostaglandin transport ----
    GO:0043252sodium-independent organic anion transport TAS--
    GO:0055085transmembrane transport TAS--

    SLCO2A1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLCO2A1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLCO2A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SLCO2A1

    10/11 DrugBank Compounds for SLCO2A1 (see all 11)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alprostadil-- 745-65-3transportersubstrate8787677 7754369
    DinoprostoneDinoprostone Prostaglandin E2 (see all 3)363-24-6transportersubstrate8787677 7754369
    Iloprost-- 78919-13-8transportersubstrate8787677 7754369
    Arachidonic Acid-- 506-32-1transportersubstrate7754369
    Fructose-1,6-Diphosphate-- --transporterinhibitor11997326
    FurosemideDihydroflumethiazide (see all 12)54-31-9transporterinhibitor7754369
    Glucose-6-Phosphate-- 56-73-5transporterinhibitor11997326
    Glyceraldehyde-3-Phosphate-- 142-10-9transporterinhibitor11997326
    Lactic Acid-- 50-21-5transporterinhibitor11997326
    Phosphoenolpyruvate-- 138-08-9transporterinhibitor11997326

    8 Novoseek chemical compound relationships for SLCO2A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostaglandin 84.1 55 15044627 (3), 15657371 (2), 16842938 (2), 14631946 (2) (see all 29)
    (+-)-pgf2-alpha 77.4 2 15044627 (1)
    oatp 70.2 2 10601278 (1)
    pge2 63.6 11 15044627 (3), 14631946 (1), 19138942 (1), 9506966 (1)
    prostaglandin f2alpha 58.1 1 11093791 (1)
    pge1 38.4 1 14631946 (1)
    indomethacin 29.3 1 12630701 (1)
    atp 0 1 12630701 (1)

    Search CenterWatch for drugs/clinical trials and news about SLCO2A1 / SO2A1 

    Transcripts
    for SLCO2A1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLCO2A1 gene: 
    NM_005630.2  

    Unigene Cluster for SLCO2A1:

    Solute carrier organic anion transporter family, member 2A1
    Hs.518270  [show with all ESTs]
    Unigene Representative Sequence: NM_005630
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310926(uc003eqa.4) ENST00000493729 ENST00000481359 ENST00000462770(uc011blv.2)
    ENST00000477061 ENST00000464676(uc010htw.1) ENST00000478651 ENST00000478662


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    hsa-miR-548p hsa-miR-125a-5p hsa-miR-3607-5p hsa-miR-3184 hsa-miR-4251 hsa-miR-1224-3p hsa-miR-4299 hsa-miR-1205
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK303550.1 AK309561.1 BC041140.1 BC051347.1 U70867.1 

    8 DOTS entries:

    DT.314904  DT.95229652  DT.100748492  DT.120894286  DT.120894293  DT.70101265  DT.91690159  DT.91747746 

    24/143 AceView cDNA sequences (see all 143):

    CA443557 AA369950 BQ272209 BM312407 AI376659 BM504792 BC041140 BM672624 
    BM710461 BQ102463 AI424234 BQ881236 BU741978 BM988738 BF446356 AA887582 
    AA913860 BU784458 BQ005081 AI200637 BU502767 AA369951 BF589463 BM126866 

    GeneLoc Exon Structure


    Expression
    for SLCO2A1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLCO2A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAATTTAAC
    SLCO2A1 Expression
    About this image

    SLCO2A1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyProximal TubuleProximal Tubule CellsKidney
    LiverLiver LobulePeriportal HepatocytesLiver
    KidneyGlomerular TuftKidney
    KidneyGlomerulusKidney
    KidneyProximal TubuleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    Definitive endoderm-like cells (Generation and expan...)
    Endoderm progenitor-like cells (Generation and expan...)
    Definitive endoderm-like cells (Generation of mesend...)
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Extraembryonic endoderm-like cells (Generation of extrae...)

    See SLCO2A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLCO2A1

    SOURCE GeneReport for Unigene cluster: Hs.518270

    UniProtKB/Swiss-Prot: SO2A1_HUMAN, Q92959
    Tissue specificity: Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart

        SABiosciences Expression via Pathway-Focused PCR Array including SLCO2A1: 
              Drug Transporters in human mouse rat

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    In Situ
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    Orthologs
    for SLCO2A1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLCO2A1 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLCO2A11 solute carrier organic anion transporter family, member more 71.41(n)
    66.77(a)    		   424862  NM_001198927.1  NP_001185856.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SLCO2A16
    		 --
    		 63(a)
    		 1 ↔ 1
    		 3(31094526-31135594)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC686572 hypothetical protein MGC68657 75.05(n)    BC060473.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii slco2a16
    		 solute carrier organic anion transporter family, m...
    		 55(a)
    		 1 ↔ 1
    		 6(27332251-27373486)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Oatp58Da6
    Oatp33Ea6
    (see all 7)    		 Organic anion transporting polypeptide 33Ea
    (see all 7)    		 22(a)
    20(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 2R(18105961-18108393)
    2L(12441401-12445924)
    worm
    (Caenorhabditis elegans)    		 Secernentea F21G4.16
    F47E1.46
    (see all 4)    		 Protein F47E1.4
    (see all 4)    		 24(a)
    20(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 X(9889257-9892270)
    X(9062779-9066602)


    ENSEMBL Gene Tree for SLCO2A1 (if available)
    TreeFam Gene Tree for SLCO2A1 (if available) 

    Paralogs
    for SLCO2A1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLCO2A1 gene
    SLCO4C12  SLCO1B72  ENSG000002570622  SLCO3A12  SLCO1B32  SLCO5A12  SLCO2B12  SLCO6A12  
    SLCO1B12  ENSG000002570462  SLCO4A12  SLCO1A22  SLCO1C12  
    15 SIMAP similar genes for SLCO2A1 using alignment to 3 protein entries:     SO2A1_HUMAN (see all proteins):
    SLC21A2    SLCO2B1    SLCO1A2    SLCO1B1    SLCO1B3    SLCO4A1
    SLCO4C1    SLCO3A1    SLCO5A1    SLCO1B7    SLCO6A1    SPINK7
    SLC21A8    SLCO1C1    LST3

    SLCO2A1 for paralogs           About GeneDecksing



    Genomic Variants
    for SLCO2A1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1841 NCBI SNPs in SLCO2A1 are shown (see all 1841)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs98200981,2
    		C,F--131029299(+) agggcG/Tcagtg 1 -- ds50014Minor allele frequency- T:0.04NA 126
    rs98207871,2
    		H--131029917(+) CCTTCC/TTGAGT 1 -- ut31 ese3 trp34Minor allele frequency- T:0.00NS EA 420
    rs563935531,2
    		C--131029981(+) TTCCAC/TAAAGA 1 -- ut311Minor allele frequency- T:0.50NA 2
    rs130770631,2
    		C,H--131030066(+) CCAGAG/AGTGGC 1 -- ut31 ese35Minor allele frequency- A:0.00NS EA NA 422
    rs558144701,2
    		C--131030132(+) AATGGC/TCATGA 1 -- ut310--------
    rs20756971,2
    		C,F--131030478(-) CCAACG/AAAGGA 1 -- ut31 ese31Minor allele frequency- A:0.01EA 1478
    rs787973271,2
    		--131030635(+) TGGGCC/TGCAGC 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs800472741,2
    		C,F--131030801(+) GGTTCT/CTCCCA 1 -- ut311Minor allele frequency- C:0.07WA 118
    rs729783881,2
    		C,F--131031386(+) CTCAGT/AGGGCA 1 -- ut313Minor allele frequency- A:0.13WA CSA 122
    rs738612581,2
    		C,F--131031876(+) CCACTG/AGGAAG 1 -- int13Minor allele frequency- A:0.05WA CSA 122

    HapMap Linkage Disequilibrium report for SLCO2A1 (133651540 - 133771028 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SLCO2A1
         1 Indel: 27163
    Human Gene Mutation Database (HGMD): SLCO2A1

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    Disorders / Diseases
    for SLCO2A1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLCO2A1 for disorders           About GeneDecksing

    OMIM gene information: 601460    OMIM disorders: --

    UniProtKB/Swiss-Prot: SO2A1_HUMAN, Q92959
  • Defects in SLCO2A1 are the cause of hypertrophic osteoarthropathy, primary, autosomal recessive, type 2
    • (PHOAR2) [MIM:614441]. PHOAR2 is a disease characterized by digital clubbing, periostosis, acroosteolysis, painful
    joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp.
    Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease

    8 diseases for SLCO2A1:    About MalaCards
    secondary hypertrophic osteoarthropathy    primary hypertrophic osteoarthropathy    gastroduodenitis    choroiditis
    alzheimer's disease    colon cancer    ischemia    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for SLCO2A1:
    Primary hypertrophic osteoarthropathy     Secondary hypertrophic osteoarthropathy
    Genetic Association Database (GAD): SLCO2A1
    Human Genome Epidemiology (HuGE) Navigator: SLCO2A1 (3 documents)

    Export disorders for SLCO2A1 gene to outside databases

    Publications
    for SLCO2A1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLCO2A1 gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with SLCO2A1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT). (PubMed id 8787677)1, 2, 3, 7, 9 Lu R.... Schuster V.L. (1996)
    2. Molecular cloning of the gene for the human prostaglandin transporter hPGT: gene organization, promoter activity, and chromosomal localization. (PubMed id 9618293)1, 2, 3 Lu R. and Schuster V.L. (1998)
    3. Mutations in the prostaglandin transporter SLCO2A1 cause primary hypertrophic osteoarthropathy with digital clubbing. (PubMed id 22696055)1, 2 Busch J.... Bergmann C. (2012)
    4. Mutations in the prostaglandin transporter encoding gene SLCO2A1 cause primary hypertrophic osteoarthropathy and isolated digital clubbing. (PubMed id 22331663)1, 2 Seifert W.... Horn D. (2012)
    5. Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy. (PubMed id 22197487)1, 2 Zhang Z.... Liu Y. (2012)
    6. Prostaglandin transporter mutations cause pachydermoperiostosis with myelofibrosis. (PubMed id 22553128)1, 2 Diggle C.P.... Bonthron D.T. (2012)
    7. Genetic factors related to unconjugated hyperbilirubinemia amongst adults. (PubMed id 15864125)1, 4 Huang C.S....Tang K.S. (2005)
    8. Regulation of prostaglandin transporters in colorectal neoplasia. (PubMed id 19138942)1, 9 Holla V.R....DuBois R.N. (2008)
    9. Expression and localization of prostaglandin transporter in Alzheimer disease brains and age-matched controls. (PubMed id 18353443)1, 9 Choi K....Dore S. (2008)
    10. Functional characterization of prostaglandin transporter and terminal prostaglandin synthases during decidualization of human endometrial stromal cells. (PubMed id 16339169)1, 9 Kang J....Fortier M.A. (2006)

    External Searches for SLCO2A1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing SLCO2A1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6578 HGNC: 10955 AceView: SLCO2A1 Ensembl:ENSG00000174640 euGenes: HUgn6578
    ECgene: SLCO2A1 H-InvDB: SLCO2A1

    Other Databases showing SLCO2A1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLCO2A1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLCO2A1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLCO2A1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLCO2A1 gene:
    Search GeneIP for patents involving SLCO2A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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