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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLCO1C1 Gene

protein-coding GIFtS: 55
GCID: GC12P020848

solute carrier organic anion transporter family, member...

(Previous names: solute carrier family 21 (organic anion transporter), member...)
(Previous symbol: SLC21A14)

Explore 7 diseases affiliated with
SLCO1C1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Organic Anion Transporter Family, Member 1C1¹ ²		Organic Anion Transporter Polypeptide-Related Protein 5² ³
SLC21A14¹ ² ³ ⁵		Organic Anion-Transporting Polypeptide 14² ³
OATP-F¹ ² ³		Solute Carrier Family 21 Member 14² ³
OATP1C1¹ ² ³		Thyroxine Transporter² ³
OATP14² ³ ⁵		OAT-RP-5² ³
OATPF² ³ ⁵		OATP-14² ³
OATP1¹ ²		OATPRP5² ³
Solute Carrier Family 21 (Organic Anion Transporter), Member 14¹ ²		Organic Anion Transporting Polypeptide 14²
Organic Anion Transporter F² ³		Solute Carrier Organic Anion Transporter Family Member 1C1²

External Ids:	HGNC: 13819¹	Entrez Gene: 53919²	Ensembl: ENSG00000139155⁷	OMIM: 613389⁵	UniProtKB: Q9NYB5³

Export aliases for SLCO1C1 gene to outside databases

Previous GC identifers: GC12P020739 GC12P020620

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLCO1C1:

This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor

that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high

affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the

gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism.

Alternative splicing results in multiple transcript variants. (provided by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: SO1C1_HUMAN, Q9NYB5

Function: Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones

thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol,

estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role

in regulating T4 flux into and out of the brain (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLCO1C1 gene promoter:
RFX1 AML1a MIF-1 HNF-3beta C/EBPalpha Evi-1 N-Myc POU2F1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLCO1C1 promoter sequence

Search SABiosciences Chromatin IP Primers for SLCO1C1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLCO1C1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.2 Ensembl cytogenetic band: 12p12.2 HGNC cytogenetic band: 12p12.2

SLCO1C1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO1C1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P020848: view genomic region (about GC identifiers)

Start:	20,848,289 bp from pter	End:	20,906,320 bp from pter
Size:	58,032 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SO1C1_HUMAN, Q9NYB5 (See protein sequence)

Recommended Name: Solute carrier organic anion transporter family member 1C1

Size: 712 amino acids; 78696 Da

Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Expressed in both luminal and abluminal

membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus

(By similarity)

Secondary accessions: B7Z251 B7Z3Q3 B7Z8P1 F5GZD6 Q5JPA4

Alternative splicing: 4 isoforms: Q9NYB5-1 Q9NYB5-2 Q9NYB5-3 Q9NYB5-4 (No experimental confirmation available. Ref.3 (BAH11737) sequence is in conflict in position: 559:S->F)

Explore the universe of human proteins at neXtProt for SLCO1C1: NX_Q9NYB5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NYB5

SLCO1C1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001139416.1 NP_001139417.1 NP_001139418.1 NP_059131.1

ENSEMBL proteins:

ENSP00000437399 ENSP00000438665 ENSP00000266509 ENSP00000444527 ENSP00000444149

ENSP00000370964

Reactome Protein details: Q9NYB5
Human Recombinant Protein Products for SLCO1C1:

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	Uscn Proteins for SLCO1C1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--

SLCO1C1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SLCO1C1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLCO1C1 for domains About GeneDecksing

5 InterPro domains/families:

IPR002350 Prot_inh_Kazal

IPR004156 OA_transporter

IPR020846 MFS_dom

IPR011497 Kazal-type_dom

IPR016196 MFS_dom_general_subst_transpt

Graphical View of Domain Structure for InterPro Entry Q9NYB5

ProtoNet protein and cluster: Q9NYB5

2 Blocks protein families:

IPB004156 Organic anion transporter polypeptide (OATP)

IPB011497 Protease inhibitor

UniProtKB/Swiss-Prot: SO1C1_HUMAN, Q9NYB5

Similarity: Belongs to the organo anion transporter (TC 2.A.60) family

Similarity: Contains 1 Kazal-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SO1C1_HUMAN, Q9NYB5

Function: Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones

thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol,

estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role

in regulating T4 flux into and out of the brain (By similarity)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	IEA	--
GO:0015125	bile acid transmembrane transporter activity	--	--

SLCO1C1 for ontologies About GeneDecksing

Phenotypes:
5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Slco1c1):

behavior/neurological

growth/size

homeostasis/metabolism

normal

reproductive system

SLCO1C1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Slco1c1^tm1.1Arte for SLCO1C1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO1C1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transport of organic anions

Transport of organic anions

1.00

Transport of vitamins, nucleosides, and related molecules

0.35

SLC-mediated transmembrane transport

SLC-mediated transmembrane transport

1.00

Transmembrane transport of small molecules

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for SLCO1C1

	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Transport of vitamins, nucleosides, and related molecules
	Transport of organic anions

SLCO1C1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLCO1C1

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for SLCO1C1 (ENSP00000266509⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PDZD3	ENSP00000327107⁴	STRING: ENSP00000327107
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015721	bile acid and bile salt transport	--	--
GO:0043252	sodium-independent organic anion transport	TAS	--
GO:0055085	transmembrane transport	TAS	--

SLCO1C1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLCO1C1

2 HMDB Compounds for SLCO1C1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Estrone sulfate	Conestoral (see all 12)	481-97-0	--
Thyroxine	(-)-Thyroxine (see all 33)	51-48-9	--

10/13 DrugBank Compounds for SLCO1C1 (see all 13) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Liotrix	--	8065-29-0	transporter	substrate inhibitor	15166123 12351693 18845642 10592235
Conjugated Estrogens	Estrogens (see all 10)	438-67-5	transporter	substrate inhibitor	15166123 12351693
Diclofenac	Diclofenac Acid (see all 4)	15307-86-5	transporter	inhibitor	18845642 10592235
Levothyroxine	(-)-Thyroxine (see all 13)	51-48-9	transporter	substrate	18845642 10592235
Liothyronine	L-Liothyronine (see all 5)	6893-02-3	transporter	substrate inhibitor	15166123 12351693
Meclofenamic acid	Acide meclofenamique [INN-French] (see all 6)	644-62-2	transporter	inhibitor	18845642 10592235
Phenytoin	5,5-diphenylhydantoin (see all 13)	57-41-0	transporter	inhibitor	18845642 10592235
Taurocholic Acid	--	81-24-3	transporter	substrate inhibitor	15166123 12351693
Digoxin	--	20830-75-5	transporter	substrate	12351693
Dinoprostone	Dinoprostone Prostaglandin E2 (see all 3)	363-24-6	transporter	substrate	12351693

Search CenterWatch for drugs/clinical trials and news about SLCO1C1 / SO1C1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLCO1C1 gene (4 alternative transcripts):

NM_001145944.1 NM_001145945.1 NM_001145946.1 NM_017435.4

Unigene Cluster for SLCO1C1:

Solute carrier organic anion transporter family, member 1C1

Hs.47261 [show with all ESTs]

Unigene Representative Sequence: AL834209

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000534996 ENST00000539415 ENST00000540354 ENST00000266509(uc001rei.3)

ENST00000497911 ENST00000535609 ENST00000545102 ENST00000539443 ENST00000545604(uc010sii.2 uc010sij.2 uc009zip.3)

ENST00000381552(uc010sik.2)

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Additional cDNA sequence:

AF205076.1 AF260704.1 AK294333.1 AK296236.1 AK303713.1 AK308729.1 AL834209.1 BC022461.2

6 DOTS entries:

DT.40236247 DT.100011468 DT.404870 DT.100653158 DT.121184752 DT.121184705

24/34 AceView cDNA sequences (see all 34):

BX095641 AL834209 CR594946 AW021931 AF260704 AL533324 BG205422 BX453785

BI552249 BC022461 AF205076 BX430994 BG200582 BV182973 BI916410 NM_017435

BG207906 BX419409 AI671274 BF447535 BI494410 BX430993 N57603 BG716696

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SLCO1C1 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17
SP1:											-		-		-				-
SP2:
SP3:											-		-		-
SP4:											-

ECgene alternative splicing isoforms for SLCO1C1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLCO1C1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTGAAAGGT

About this image

SLCO1C1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

9 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Choroid Plexus

Mature Choroid Plexus Cells

Selective marker (cell-identifying gene)

Choroid Plexus

Brain

Blood Brain Barrier

Adult Endothelial Cells

Blood Brain Barrier, Endothelium

Brain

Blood Brain Barrier

Endothelial Cells

Blood Brain Barrier, Endothelium

Brain

Blood Brain Barrier

Postnatal Endothelial Cells

Blood Brain Barrier, Endothelium

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Brain

Brain

Brain

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLCO1C1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLCO1C1

SOURCE GeneReport for Unigene cluster: Hs.47261

UniProtKB/Swiss-Prot: SO1C1_HUMAN, Q9NYB5

Tissue specificity: Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the

exception of pons and cerebellum. Not strongly enriched in cerebral microvessels

SABiosciences Custom PCR Arrays for SLCO1C1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO1C1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SLCO1C1 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLCO1C1¹	solute carrier organic anion transporter family, member more	72.25(n) 71.97(a)		418186 NM_001039097.1 NP_001034186.1
lizard (Anolis carolinensis)	Reptilia	SLCO1C1⁶	--	67(a)	1 ↔ 1	5(8443122-8469224)
zebrafish (Danio rerio)	Actinopterygii	slco1c1¹	solute carrier organic anion transporter family, member more	62.72(n) 61.83(a)		562772 NM_001044997.3 NP_001038462.2
fruit fly (Drosophila melanogaster)	Insecta	Oatp58Da⁶ Oatp58Db⁶ (see all 7)	Organic anion transporting polypeptide 58Db (see all 7)	23(a) 22(a) (see all 7)	many ↔ many many ↔ many (see all 7)	2R(18105961-18108393) 2R(18108685-18111095)
worm (Caenorhabditis elegans)	Secernentea	F21G4.1⁶ Y32F6B.1⁶ (see all 4)	Protein Y32F6B.1 (see all 4)	22(a) 20(a) (see all 4)	many ↔ many many ↔ many (see all 4)	X(9889257-9892270) V(10480923-10484717)

ENSEMBL Gene Tree for SLCO1C1 (if available)
TreeFam Gene Tree for SLCO1C1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLCO1C1 gene

SLCO2A1² SLCO4C1² SLCO1B7² ENSG00000257062² SLCO3A1² SLCO1B3² SLCO5A1² SLCO2B1²

SLCO6A1² SLCO1B1² ENSG00000257046² SLCO4A1² SLCO1A2²

12 SIMAP similar genes for SLCO1C1 using alignment to 3 protein entries: SO1C1_HUMAN (see all proteins):

SLCO1B3 SLCO1B1 SLC21A8 SLCO1A2 LST3 SLCO1B7

SLCO3A1 SLCO2B1 SLCO4C1 SLCO5A1 SLCO4A1 SLCO2A1

SLCO1C1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191060452^1,2		--	20846326(+)	`CCTGGG/TAAGAT`	2	--	us2k¹		0	--	--	--	--
rs146544091^1,2		--	20846329(+)	`GGGAAG/TATCAA`	2	--	us2k¹		0	--	--	--	--
rs183260836^1,2		--	20846488(+)	`CCCCCA/GGTACC`	4	--	us2k¹		0	--	--	--	--
rs139720841^1,2		--	20846520(+)	`AAAGAC/GAGTCT`	4	--	us2k¹		0	--	--	--	--
rs72658760^1,2	C	--	20846588(+)	`CTAGCG/ATTTTT`	4	--	us2k¹		5		WA NA EA	362
rs7962073^1,2	C,H	--	20846596(+)	`TTTTTA/TAGTAC`	4	--	us2k¹		4		NS EA	416
rs149792307^1,2		--	20846703(+)	`AAACAC/TCAGGA`	4	--	us2k¹		0	--	--	--	--
rs72658761^1,2	C	--	20846900(+)	`TTAATT/ATACCA`	4	--	us2k¹		4		WA NA EA	360
rs78069643^1,2	F	--	20846981(+)	`TGTCCC/GTTTAT`	4	--	us2k¹		1		WA	118
rs188738023^1,2		--	20846982(+)	`GTCCCC/TTTATA`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLCO1C1 (20848289 - 20906320 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for SLCO1C1
1 CNV: 71474
5 Indels: 61213 39885 101447 45021 42097
Human Gene Mutation Database (HGMD): SLCO1C1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SLCO1C1 for disorders           About GeneDecksing

OMIM gene information: 613389    OMIM disorders: --

7 diseases for SLCO1C1:    About MalaCards

allan-herndon-dudley syndrome thyroiditis hyperthyroidism cholestasis

hypothyroidism choroiditis cerebritis

1 disease from the University of Copenhagen DISEASES database for SLCO1C1:

Cholestasis

Human Genome Epidemiology (HuGE) Navigator: SLCO1C1 (3 documents)

Export disorders for SLCO1C1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SLCO1C1 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with SLCO1C1)

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Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. (PubMed id 12351693)^{1, 2, 7} Pizzagalli F....Meier P.J. (2002)
Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier. (PubMed id 18687783)^{1, 2, 9} Roberts L.M....Zerangue N. (2008)
Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs. (PubMed id 18845642)^{1, 7} Westholm D.E....Anderson G.W. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Thyroid hormone transport and metabolism by OATP1C1 and consequences of genetic variation. (PubMed id 18566113)^{1, 9} van der Deure W.M....Visser T.J. (2008)
ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier. (PubMed id 16357150)^{1, 9} Bronger H....Nies A.T. (2005)
Investigation of single nucleotide polymorphisms and b iological pathways associated with response to TNFa inhibitors in patients with rheumatoid arthritis. (PubMed id 22569225)¹ Krintel S.B....Hetland M.L. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodiff erentiation. (PubMed id 21486766)¹ Chan S.Y....Kilby M.D. (2011)
Expression of thyroid hormone transporters in the hum an hypothalamus. (PubMed id 21508134)¹ Alkemade A....Fliers E. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 53919	HGNC: 13819	AceView: SLCO1C1	Ensembl:ENSG00000139155	euGenes: HUgn53919
ECgene: SLCO1C1	H-InvDB: SLCO1C1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SLCO1C1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLCO1C1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SLCO1C1 gene:
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