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Aliases for SLCO1C1 Gene

Aliases for SLCO1C1 Gene

  • Solute Carrier Organic Anion Transporter Family Member 1C1 2 3 5
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 14 2 3
  • Solute Carrier Organic Anion Transporter Family, Member 1C1 2 3
  • Organic Anion Transporter Polypeptide-Related Protein 5 3 4
  • Organic Anion-Transporting Polypeptide 14 3 4
  • Solute Carrier Family 21 Member 14 3 4
  • Organic Anion Transporter F 3 4
  • Thyroxine Transporter 3 4
  • SLC21A14 3 4
  • OAT-RP-5 3 4
  • OATP-14 3 4
  • OATP1C1 3 4
  • OATPRP5 3 4
  • OATP-F 3 4
  • OATP14 3 4
  • OATPF 3 4
  • Organic Anion Transporting Polypeptide 14 3
  • OATP1 3

External Ids for SLCO1C1 Gene

Previous HGNC Symbols for SLCO1C1 Gene

  • SLC21A14

Previous GeneCards Identifiers for SLCO1C1 Gene

  • GC12P020739
  • GC12P020848
  • GC12P020620

Summaries for SLCO1C1 Gene

Entrez Gene Summary for SLCO1C1 Gene

  • This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

GeneCards Summary for SLCO1C1 Gene

SLCO1C1 (Solute Carrier Organic Anion Transporter Family Member 1C1) is a Protein Coding gene. Diseases associated with SLCO1C1 include allan-herndon-dudley syndrome and chronic cholangitis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. GO annotations related to this gene include transporter activity and transmembrane transporter activity. An important paralog of this gene is SLCO1B7.

UniProtKB/Swiss-Prot for SLCO1C1 Gene

  • Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO1C1 Gene

Genomics for SLCO1C1 Gene

Regulatory Elements for SLCO1C1 Gene

Genomic Location for SLCO1C1 Gene

Chromosome:
12
Start:
20,695,355 bp from pter
End:
20,753,386 bp from pter
Size:
58,032 bases
Orientation:
Plus strand

Genomic View for SLCO1C1 Gene

Genes around SLCO1C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO1C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO1C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO1C1 Gene

Proteins for SLCO1C1 Gene

  • Protein details for SLCO1C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYB5-SO1C1_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 1C1
    Protein Accession:
    Q9NYB5
    Secondary Accessions:
    • B7Z251
    • B7Z3Q3
    • B7Z8P1
    • F5GZD6
    • Q5JPA4

    Protein attributes for SLCO1C1 Gene

    Size:
    712 amino acids
    Molecular mass:
    78696 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLCO1C1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLCO1C1 Gene

Proteomics data for SLCO1C1 Gene at MOPED

Post-translational modifications for SLCO1C1 Gene

  • Glycosylation at Asn 146, Asn 510, Asn 520, and Asn 533
  • Modification sites at PhosphoSitePlus

Other Protein References for SLCO1C1 Gene

Antibody Products

No data available for DME Specific Peptides for SLCO1C1 Gene

Domains & Families for SLCO1C1 Gene

Gene Families for SLCO1C1 Gene

Suggested Antigen Peptide Sequences for SLCO1C1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYB5

UniProtKB/Swiss-Prot:

SO1C1_HUMAN :
  • Contains 1 Kazal-like domain.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
Domain:
  • Contains 1 Kazal-like domain.
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO1C1: view

Function for SLCO1C1 Gene

Molecular function for SLCO1C1 Gene

UniProtKB/Swiss-Prot Function:
Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity).

Gene Ontology (GO) - Molecular Function for SLCO1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015125 bile acid transmembrane transporter activity IBA --
GO:0015349 thyroid hormone transmembrane transporter activity IEA,TAS --
genes like me logo Genes that share ontologies with SLCO1C1: view
genes like me logo Genes that share phenotypes with SLCO1C1: view

Animal Models for SLCO1C1 Gene

MGI Knock Outs for SLCO1C1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLCO1C1 Gene

Localization for SLCO1C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO1C1 Gene

Cell membrane; Multi-pass membrane protein. Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLCO1C1 Gene COMPARTMENTS Subcellular localization image for SLCO1C1 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SLCO1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLCO1C1: view

Pathways & Interactions for SLCO1C1 Gene

genes like me logo Genes that share pathways with SLCO1C1: view

Interacting Proteins for SLCO1C1 Gene

Gene Ontology (GO) - Biological Process for SLCO1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0043252 sodium-independent organic anion transport TAS --
GO:0070327 thyroid hormone transport IEA,TAS --
genes like me logo Genes that share ontologies with SLCO1C1: view

No data available for SIGNOR curated interactions for SLCO1C1 Gene

Drugs & Compounds for SLCO1C1 Gene

(23) Drugs for SLCO1C1 Gene - From: IUPHAR, DGIdb, DrugBank, PharmGKB, HMDB, FDA Approved Drugs, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Probenecid Approved Pharma Inhibition, Inhibitor, blocker, Transporter, inhibitor 27
Levothyroxine Approved Pharma Transporter, substrate 0
Liotrix Approved Pharma Transporter, substrate, inhibitor 0
Meclofenamic acid Approved Pharma Transporter, inhibitor 1
Methotrexate Approved Pharma Transporter, substrate Folate antagonist,inhibits DFHR, Cytotoxic agent 1444

(4) Additional Compounds for SLCO1C1 Gene - From: HMDB and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
TCA
Inhibition, Inhibitor
3',4'-Dihydrodiol
4'-Hydroxydiclofenac
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid
  • 4'-Hydroxy diclofenac
  • 4'-OH DCF
  • {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
64118-84-9
estrone sulfate
  • Conestoral
  • Estrogenic substances
  • Estrone
  • Estrone hydrogen sulfate
  • Estrone hydrogen sulphate
481-97-0

(1) ApexBio Compounds for SLCO1C1 Gene

Compound Action Cas Number
Probenecid 57-66-9
genes like me logo Genes that share compounds with SLCO1C1: view

Transcripts for SLCO1C1 Gene

Unigene Clusters for SLCO1C1 Gene

Solute carrier organic anion transporter family, member 1C1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO1C1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - -
SP2:
SP3: - - -
SP4: -

Relevant External Links for SLCO1C1 Gene

GeneLoc Exon Structure for
SLCO1C1
ECgene alternative splicing isoforms for
SLCO1C1

Expression for SLCO1C1 Gene

mRNA expression in normal human tissues for SLCO1C1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO1C1 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x7.9), Brain - Nucleus accumbens (basal ganglia) (x7.0), Brain - Putamen (basal ganglia) (x6.1), Brain - Amygdala (x6.0), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Cortex (x4.2).

SOURCE GeneReport for Unigene cluster for SLCO1C1 Gene Hs.47261

mRNA Expression by UniProt/SwissProt for SLCO1C1 Gene

Q9NYB5-SO1C1_HUMAN
Tissue specificity: Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels.
genes like me logo Genes that share expression patterns with SLCO1C1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SLCO1C1 Gene

Orthologs for SLCO1C1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLCO1C1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLCO1C1 35
  • 89.27 (n)
  • 89.06 (a)
SLCO1C1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLCO1C1 35
  • 90.26 (n)
  • 90.45 (a)
SLCO1C1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slco1c1 35
  • 84.25 (n)
  • 84.11 (a)
Slco1c1 16
Slco1c1 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLCO1C1 35
  • 99.64 (n)
  • 99.69 (a)
SLCO1C1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slco1c1 35
  • 84.36 (n)
  • 84.83 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SLCO1C1 36
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLCO1C1 35
  • 72.25 (n)
  • 71.97 (a)
SLCO1C1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLCO1C1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slco1c1 35
  • 65.71 (n)
  • 67.62 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12238 35
zebrafish
(Danio rerio)
Actinopterygii slco1c1 36
  • 54 (a)
OneToOne
slco1c1 35
  • 62.5 (n)
  • 61.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
CSA.1414 36
  • 31 (a)
OneToMany
Species with no ortholog for SLCO1C1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLCO1C1 Gene

ENSEMBL:
Gene Tree for SLCO1C1 (if available)
TreeFam:
Gene Tree for SLCO1C1 (if available)

Paralogs for SLCO1C1 Gene

(12) SIMAP similar genes for SLCO1C1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLCO1C1: view

Variants for SLCO1C1 Gene

Sequence variations from dbSNP and Humsavar for SLCO1C1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs952658 -- 20,712,367(-) CTCTA(C/T)TTCAG intron-variant
rs953001 -- 20,752,693(+) TGAAA(C/T)ATATA utr-variant-3-prime
rs953002 -- 20,752,763(+) TATCA(C/T)TTACT utr-variant-3-prime
rs959346 -- 20,699,152(-) AAAGC(C/T)TTTAA intron-variant, upstream-variant-2KB
rs966864 -- 20,713,802(-) CACTT(C/T)CTCTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLCO1C1 Gene

Variant ID Type Subtype PubMed ID
nsv635 CNV Insertion 18451855
esv2037706 CNV Deletion 18987734
esv3591 CNV Deletion 18987735
esv2745622 CNV Deletion 23290073
esv2532269 CNV Deletion 19546169
esv990517 CNV Deletion 20482838
esv7360 CNV Loss 19470904
nsv523367 CNV Loss 19592680
nsv826279 CNV Loss 20364138
esv2659248 CNV Deletion 23128226
esv24973 CNV Gain 19812545

Variation tolerance for SLCO1C1 Gene

Residual Variation Intolerance Score: 38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.61; 97.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLCO1C1 Gene

HapMap Linkage Disequilibrium report
SLCO1C1
Human Gene Mutation Database (HGMD)
SLCO1C1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO1C1 Gene

Disorders for SLCO1C1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLCO1C1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
allan-herndon-dudley syndrome
  • allan-herndon syndrome
chronic cholangitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLCO1C1

Genetic Association Database (GAD)
SLCO1C1
Human Genome Epidemiology (HuGE) Navigator
SLCO1C1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLCO1C1
genes like me logo Genes that share disorders with SLCO1C1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLCO1C1 Gene

Publications for SLCO1C1 Gene

  1. Thyroid hormone transport and metabolism by organic anion transporter 1C1 and consequences of genetic variation. (PMID: 18566113) van der Deure W.M. … Visser T.J. (Endocrinology 2008) 3 23 48 67
  2. Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs. (PMID: 18845642) Westholm D.E. … Anderson G.W. (Endocrinology 2009) 3 25 26
  3. Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. (PMID: 12351693) Pizzagalli F. … Meier P.J. (Mol. Endocrinol. 2002) 3 25 26
  4. Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier. (PMID: 18687783) Roberts L.M. … Zerangue N. (Endocrinology 2008) 3 23
  5. ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier. (PMID: 16357150) Bronger H. … Nies A.T. (Cancer Res. 2005) 3 23

Products for SLCO1C1 Gene

Sources for SLCO1C1 Gene

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