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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLCO1B7 Gene

protein-coding   GIFtS: 36
GCID: GC12P020980

Solute Carrier Organic Anion Transporter Family, Member...

  Search for SLCO1B7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Organic Anion Transporter Family, Member 1B7
(Non-Functional)1 2
     SLC21A212
Liver-Specific Organic Anion Transporter 32 3     Liver-Specific Organic Anion Transporter 3TM122
LST-32 3     Organic Anion Transporter LST-3b2
LST32 3     Putative Solute Carrier Organic Anion Transporter Family Member 1B72
LST-3TM122     LST3TM123

External Ids:    HGNC: 329341   Entrez Gene: 3388212   Ensembl: ENSG000002057547   UniProtKB: G3V0H73   

Export aliases for SLCO1B7 gene to outside databases

Previous GC identifers: GC12P021169 GC12P020969 GC12P020970 GC12P020975


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLCO1B7 Gene: 
SLCO1B7 (solute carrier organic anion transporter family, member 1B7 (non-functional)) is a protein-coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLCO2A1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SLCO1B7
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLCO1B7 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLCO1B7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLCO1B7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.2   Ensembl cytogenetic band:  12p12.2   HGNC cytogenetic band: 12p12.3

SLCO1B7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO1B7 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P020980:  view genomic region     (about GC identifiers)

Start:
20,968,673 bp from pter      End:
21,245,679 bp from pter
Size:
277,007 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SO1B7_HUMAN, G3V0H7 (See protein sequence)
Recommended Name: Putative solute carrier organic anion transporter family member 1B7  
Size: 640 amino acids; 71247 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (Potential)
Caution: Product of a dubious CDS prediction. May encode a non-functional truncated protein
Secondary accessions: Q71QF0

Explore the universe of human proteins at neXtProt for SLCO1B7: NX_G3V0H7

Explore proteomics data for SLCO1B7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_G3V0H7

  • SLCO1B7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLCO1B7 Protein Expression
    REFSEQ proteins: NP_001009562.3  
    ENSEMBL proteins: 
     ENSP00000394168   ENSP00000439857   ENSP00000452013  

    Human Recombinant Protein Products for SLCO1B7: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SLCO1B7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    4 InterPro protein domains:
     IPR002350 Kazal_dom
     IPR004156 OA_transporter
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry G3V0H7

    ProtoNet protein and cluster: G3V0H7

    UniProtKB/Swiss-Prot: SO1B7_HUMAN, G3V0H7
    Similarity: Belongs to the organo anion transporter (TC 2.A.60) family
    Similarity: Contains 1 Kazal-like domain


    SLCO1B7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005515protein binding ----
    GO:0022857transmembrane transporter activity ----
         
    SLCO1B7 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLCO1B7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Bile secretion
    Bile secretion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for SLCO1B7):
        Bile secretion


    SLCO1B7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLCO1B7

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0055085transmembrane transport ----

    SLCO1B7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLCO1B7 (SO1B7)

    Search CenterWatch for drugs/clinical trials and news about SLCO1B7 / SO1B7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLCO1B7 gene: 
    NM_001009562.4  

    Unigene Cluster for SLCO1B7:

    Solute carrier organic anion transporter family, member 1B7 (non-functional)
    Hs.729117  [show with all ESTs]
    Unigene Representative Sequence: AF401642
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000421593(uc010sin.2) ENST00000545916 ENST00000541784 ENST00000554957

    miRNA
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    Inhib. RNA
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    Primer
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    Additional mRNA sequence: AF401642.1 

    1 DOTS entry:

    DT.102824387 

    24/40 AceView cDNA sequences (see all 40):

    BG618727 CB161880 AA382692 CB163667 CB161473 BX283296 AB026257 CB161434 
    BG562880 BG567055 BM764855 BC070172 AF401642 BX283459 AF205071 AF060500 
    BG568493 BX507379 BG569568 BG569386 BX495197 CB164145 BC005243 BC054878 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLCO1B7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAGGATAC
    SLCO1B7 Expression
    About this image


    See SLCO1B7 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.729117
        SABiosciences Custom PCR Arrays for SLCO1B7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO1B7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLCO1B7 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SLCO1B36
    --
    --
    40(a)
    37(a)
    1 ↔ many
    possible ortholog
    1(65317306-65337388)
    1(65337214-65368820)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    42(a)
    38(a)
    1 ↔ many
    possible ortholog
    5(8410455-8428198)
    5(8382878-8408937)
    zebrafish
    (Danio rerio)
    Actinopterygii slco1d16
    slco1f46
    (see all 8)
    solute carrier organic anion transporter family, m...
    solute carrier organic anion transporter family, m...
    (see all 8)
    41(a)
    41(a)
    (see all 8)
    possible ortholog
    possible ortholog
    (see all 8)
    Zv9_NA995(3331-39201)
    4(60470768-60490279)
    fruit fly
    (Drosophila melanogaster)
    Insecta Oatp58Db6
    Oatp33Ea6
    (see all 6)
    Organic anion transporting polypeptide 33Ea
    (see all 6)
    20(a)
    19(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    2R(18108685-18111095)
    2L(12441401-12445924)
    worm
    (Caenorhabditis elegans)
    Secernentea F21G4.16
    F47E1.46
    (see all 4)
    Protein F47E1.4
    (see all 4)
    23(a)
    21(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    X(9889315-9892328)
    X(9062834-9066657)
            Species with no ortholog for SLCO1B7

    ENSEMBL Gene Tree for SLCO1B7 (if available)
    TreeFam Gene Tree for SLCO1B7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLCO1B7 gene
    SLCO2A12  SLCO4C12  ENSG000002570622  SLCO1B32  SLCO3A12  SLCO2B12  SLCO5A12  SLCO1B12  
    SLCO6A12  SLCO1A22  ENSG000002570462  SLCO4A12  SLCO1C12  
    13 SIMAP similar genes for SLCO1B7 using alignment to 3 protein entries:     SO1B7_HUMAN (see all proteins):
    SLCO1B3    SLC21A8    LST3    SLCO1B1    SLCO1A2    SLCO1C1
    SLCO3A1    DKFZp313M176    SLCO2B1    SLCO4C1    SLCO4A1    SLCO5A1
    SLCO2A1

    SLCO1B7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1922 SNPs in SLCO1B7 are shown (see all 1922)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs560898481,2
    C--21076335(+) GGAGT-/GAAA  
     TGAGGGT
    ATATG
    1 -- int10--------
    rs1466816021,2
    --21166636(+) TTCAGC/TATAAA 1 -- us2k10--------
    rs1882276301,2
    --21166649(+) TTTGGA/GGGGAA 1 -- us2k10--------
    rs1929271091,2
    --21166961(+) AATAGC/TTCACC 1 -- us2k10--------
    rs1827775871,2
    --21166974(+) TGTGGC/TCATCT 1 -- us2k10--------
    rs1880344081,2
    --21167013(+) AGTTAA/GTGATA 1 -- us2k10--------
    rs1913733131,2
    --21167026(+) AATTTA/TAAAAT 1 -- us2k10--------
    rs1850335121,2
    --21167152(+) AGATTA/GCAAAA 1 -- us2k10--------
    rs589878531,2
    C,F--21167211(+) GACACC/TTCTCA 1 -- us2k15Minor allele frequency- T:0.37WA CSA 125
    rs1895622221,2
    --21167224(+) AGAAAA/CCATTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLCO1B7 (20968673 - 21218673 bp, first 250kb of SLCO1B7)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SLCO1B7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv898879CNV Loss21882294
    nsv469159CNV Loss19166990
    nsv898878CNV Loss21882294
    nsv898877CNV Loss21882294
    nsv898872CNV Loss21882294
    nsv515735CNV Gain+Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLCO1B7 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SLCO1B7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition. (PubMed id 20837016)1 Buch S....Hampe J. (2010)
    2. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
    3. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 338821 HGNC: 32934 AceView: SLCO1B1andLST-3 Ensembl:ENSG00000205754 euGenes: HUgn338821
    ECgene: SLCO1B7 Kegg: 338821 H-InvDB: SLCO1B7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLCO1B7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLCO1B7 gene:
    Search GeneIP for patents involving SLCO1B7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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