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SLCO1B7 Gene

protein-coding   GIFtS: 31
GCID: GC12P020985

Solute Carrier Organic Anion Transporter Family, Member...

  Search for SLCO1B7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Organic Anion Transporter Family, Member 1B7
(Non-Functional)1 2
     SLC21A212
Liver-Specific Organic Anion Transporter 32 3     Liver-Specific Organic Anion Transporter 3TM122
LST-32 3     Organic Anion Transporter LST-3b2
LST32 3     Putative Solute Carrier Organic Anion Transporter Family Member 1B72
LST-3TM122     LST3TM123

External Ids:    HGNC: 329341   Entrez Gene: 3388212   Ensembl: ENSG000002057547   UniProtKB: G3V0H73   

Export aliases for SLCO1B7 gene to outside databases

Previous GC identifers: GC12P021169 GC12P020969 GC12P020970 GC12P020975 GC12P020980


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLCO1B7 Gene:
SLCO1B7 (solute carrier organic anion transporter family, member 1B7 (non-functional)) is a protein-coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLCO2A1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for SLCO1B7
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLCO1B7 promoter sequence
   Search Chromatin IP Primers for SLCO1B7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLCO1B7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.2   Ensembl cytogenetic band:  12p12.2   HGNC cytogenetic band: 12p12.3

SLCO1B7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO1B7 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P020985:  view genomic region     (about GC identifiers)

Start:
20,968,673 bp from pter      End:
21,245,679 bp from pter
Size:
277,007 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SO1B7_HUMAN, G3V0H7 (See protein sequence)
Recommended Name: Putative solute carrier organic anion transporter family member 1B7  
Size: 640 amino acids; 71247 Da
Caution: Product of a dubious CDS prediction. May encode a non-functional truncated protein
Secondary accessions: Q71QF0

Explore the universe of human proteins at neXtProt for SLCO1B7: NX_G3V0H7

Explore proteomics data for SLCO1B7 at MOPED


See SLCO1B7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001009562.3  
ENSEMBL proteins: 
 ENSP00000394168   ENSP00000439857   ENSP00000452013  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SLC: Solute carriers

4 InterPro protein domains:
 IPR002350 Kazal_dom
 IPR004156 OA_transporter
 IPR020846 MFS_dom
 IPR016196 MFS_dom_general_subst_transpt

Graphical View of Domain Structure for InterPro Entry G3V0H7

ProtoNet protein and cluster: G3V0H7

UniProtKB/Swiss-Prot: SO1B7_HUMAN, G3V0H7
Similarity: Belongs to the organo anion transporter (TC 2.A.60) family
Similarity: Contains 1 Kazal-like domain


SLCO1B7 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005215transporter activity IEA--
GO:0005515protein binding ----
GO:0022857transmembrane transporter activity ----
     
SLCO1B7 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
SO1B7_HUMAN, G3V0H7: Cell membrane; Multi-pass membrane protein (Potential)

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0016020membrane ----
GO:0016021integral component of membrane IEA--

SLCO1B7 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SLCO1B7 About                                                                                                See pathways by source

SuperPathContained pathways About
1Bile secretion
Bile secretion

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Kegg Pathway  (Kegg details for SLCO1B7):
    Bile secretion


SLCO1B7 for pathways           About GeneDecksing

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Interactions:

    Search GeneGlobe Interaction Network for SLCO1B7

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006810transport ----
GO:0055085transmembrane transport ----

SLCO1B7 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for SLCO1B7 (SO1B7)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SLCO1B7 gene: 
NM_001009562.4  

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000421593(uc010sin.2) ENST00000545916 ENST00000541784 ENST00000554957

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Selected AceView cDNA sequences (see all 40):

CB163667 AB026257 CB161434 BG562880 BX283296 CB161880 AA382692 CB161473 
BG618727 CB163230 BC005243 AF205071 BX507379 BX495197 NM_006446 AF060500 
BG568633 CB164145 BC070172 H62927 BG567055 BM764855 BX283459 BG569386 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SLCO1B7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAAAGGATAC
SLCO1B7 Expression
About this image

SLCO1B7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SLCO1B7 Protein Expression
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for SLCO1B7 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
35(a)
1 → many
1(65382381-65399776)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
33(a)
1 → many
5(8325221-8353497)
        Species with no ortholog for SLCO1B7

ENSEMBL Gene Tree for SLCO1B7 (if available)
TreeFam Gene Tree for SLCO1B7 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SLCO1B7 gene
SLCO2A12  SLCO4C12  ENSG000002570622  SLCO1B32  SLCO3A12  SLCO2B12  SLCO5A12  SLCO1B12  
SLCO6A12  SLCO1A22  ENSG000002570462  SLCO4A12  SLCO1C12  
13 SIMAP similar genes for SLCO1B7 using alignment to 3 protein entries:     SO1B7_HUMAN (see all proteins):
SLCO1B3    SLC21A8    LST3    SLCO1B1    SLCO1A2    SLCO1C1
SLCO3A1    DKFZp313M176    SLCO2B1    SLCO4C1    SLCO4A1    SLCO5A1
SLCO2A1

SLCO1B7 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SLCO1B7 (see all 1922)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs560898481,2
C--21076335(+) GGAGT-/GAAA  
 TGAGGGT
ATATG
1 -- int10--------
rs1466816021,2
--21166636(+) TTCAGC/TATAAA 1 -- us2k10--------
rs1882276301,2
--21166649(+) TTTGGA/GGGGAA 1 -- us2k10--------
rs1929271091,2
--21166961(+) AATAGC/TTCACC 1 -- us2k10--------
rs1827775871,2
--21166974(+) TGTGGC/TCATCT 1 -- us2k10--------
rs1880344081,2
--21167013(+) AGTTAA/GTGATA 1 -- us2k10--------
rs1913733131,2
--21167026(+) AATTTA/TAAAAT 1 -- us2k10--------
rs1850335121,2
--21167152(+) AGATTA/GCAAAA 1 -- us2k10--------
rs589878531,2
C,F--21167211(+) GACACC/TTCTCA 1 -- us2k15Minor allele frequency- T:0.37WA CSA 125
rs1895622221,2
--21167224(+) AGAAAA/CCATTT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for SLCO1B7 (20968673 - 21218673 bp, first 250kb of SLCO1B7)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for SLCO1B7:    About this table    
Variant IDTypeSubtypePubMed ID
nsv898879CNV Loss21882294
nsv469159CNV Loss19166990
nsv898878CNV Loss21882294
nsv898877CNV Loss21882294
nsv898872CNV Loss21882294
nsv515735CNV Gain+Loss19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SLCO1B7 gene integrated from 10 sources:
(articles sorted by number of sources associating them with SLCO1B7)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition. (PubMed id 20837016)1 Buch S....Hampe J. (Gastroenterology 2010)
  2. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
  3. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 338821 HGNC: 32934 AceView: SLCO1B1andLST-3 Ensembl:ENSG00000205754 euGenes: HUgn338821
ECgene: SLCO1B7 Kegg: 338821 H-InvDB: SLCO1B7

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SLCO1B7 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SLCO1B7 gene:
Search GeneIP for patents involving SLCO1B7

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 SwitchGear 3'UTR luciferase reporter plasmids for SLCO1B7
 SwitchGear Promoter luciferase reporter plasmids for SLCO1B7
 Search ThermoFisher Antibodies for SLCO1B7
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SLCO1B7
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLCO1B7
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLCO1B7
 LSBio Antibodies in human, mouse, rat for SLCO1B7
Customized transgenic rodents for:
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 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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