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SLCO1B3 Gene

protein-coding   GIFtS: 59
GCID: GC12P020963

Solute Carrier Organic Anion Transporter Family, Member...

(Previous names: solute carrier family 21 (organic anion transporter), member...)
(Previous symbol: SLC21A8)
  See SLCO1B3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Organic Anion Transporter Family, Member 1B31 2     OATP82 5
SLC21A81 2 5     LST-3TM132
OATP1B32 3 5     LST32
Solute Carrier Family 21 (Organic Anion Transporter), Member 81 2     Liver-Specific Organic Anion Transporter 3TM132
Liver-Specific Organic Anion Transporter 22 3     Organic Anion Transporter LST-3c2
Organic Anion Transporter 82 3     Solute Carrier Organic Anion Transporter Family Member 1B32
Organic Anion-Transporting Polypeptide 82 3     LST23
LST-22 3     OATP8,SLC21A83
OATP-82 3     Solute Carrier Family 21 Member 83
HBLRR2 5     

External Ids:    HGNC: 109611   Entrez Gene: 282342   Ensembl: ENSG000001117007   OMIM: 6054955   UniProtKB: Q9NPD53   

Export aliases for SLCO1B3 gene to outside databases

Previous GC identifers: GC12P020859 GC12P020736


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLCO1B3 Gene:
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a
transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and
plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type
hyperbilirubinemia. (provided by RefSeq, Feb 2012)

GeneCards Summary for SLCO1B3 Gene:
SLCO1B3 (solute carrier organic anion transporter family, member 1B3) is a protein-coding gene. Diseases associated with SLCO1B3 include hyperbilirubinemia, rotor type, digenic, and rotor syndrome. GO annotations related to this gene include organic anion transmembrane transporter activity. An important paralog of this gene is SLCO2A1.

UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5
Function: Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol,
taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and
sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver

Gene Wiki entry for SLCO1B3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLCO1B3 gene promoter:
         ATF-2   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   STAT5A   POU3F2   HNF-4alpha1   PPAR-gamma1   PPAR-gamma2   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SLCO1B3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLCO1B3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12   Ensembl cytogenetic band:  12p12.2   HGNC cytogenetic band: 12p12

SLCO1B3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO1B3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P020963:  view genomic region     (about GC identifiers)

Start:
20,963,636 bp from pter      End:
21,243,040 bp from pter
Size:
279,405 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5 (See protein sequence)
Recommended Name: Solute carrier organic anion transporter family member 1B3  
Size: 702 amino acids; 77403 Da

Explore the universe of human proteins at neXtProt for SLCO1B3: NX_Q9NPD5

Explore proteomics data for SLCO1B3 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn134, Asn145, Asn151, Asn445, Asn503, Asn516
  • Modification sites at PhosphoSitePlus

  • See SLCO1B3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_062818.1  
    ENSEMBL proteins: 
     ENSP00000442000   ENSP00000370956   ENSP00000443225   ENSP00000451758   ENSP00000261196  
    Reactome Protein details: Q9NPD5

    SLCO1B3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for SLCO1B3
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    Novus Biologicals SLCO1B3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLCO1B3

     
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    antibodies-online peptides for SLCO1B3

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    antibodies-online antibodies for SLCO1B3 (13 products) 

    SLCO1B3 Assay Products:

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    antibodies-online kits for SLCO1B3 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: OATP1B3
    SLCO family of organic anion transporting polypeptides

    4 InterPro protein domains:
     IPR002350 Kazal_dom
     IPR004156 OA_transporter
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9NPD5

    ProtoNet protein and cluster: Q9NPD5

    2 Blocks protein domains:
    IPB004156 Organic anion transporter polypeptide (OATP)
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5
    Similarity: Belongs to the organo anion transporter (TC 2.A.60) family
    Similarity: Contains 1 Kazal-like domain


    Find genes that share domains with SLCO1B3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SO1B3_HUMAN, Q9NPD5
    Function: Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol,
    taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and
    sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005515protein binding ----
    GO:0008514organic anion transmembrane transporter activity TAS10779507
         
    Find genes that share ontologies with SLCO1B3           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slco1b2):
     homeostasis/metabolism  liver/biliary system  mortality/aging 

    Find genes that share phenotypes with SLCO1B3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slco1b2tm1Cdk for SLCO1B3

       genOway: Develop your customized and physiologically relevant rodent model for SLCO1B3

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate SLCO1B3:
    hsa-miR-607
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SLCO1B3 (NM_019844)
    Sino Biological Human cDNA Clone for SLCO1B3
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO1B3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SO1B3_HUMAN, Q9NPD5: Basolateral cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS10779507
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with SLCO1B3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLCO1B3 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Statin Pathway - Generalized, Pharmacokinetics
    Statin Pathway - Generalized, Pharmacokinetics0.50
    Pravastatin Pathway, Pharmacokinetics0.00
    Ibuprofen Pathway, Pharmacokinetics0.50
    Fluvastatin Pathway, Pharmacokinetics0.00
    Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics0.00
    Rosuvastatin Pathway, Pharmacokinetics0.00
    2Synthesis of bile acids and bile salts
    Bile acid and bile salt metabolism0.73
    Recycling of bile acids and salts0.00
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transmembrane transport of small molecules0.47
    4Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    5Irinotecan Pathway, Pharmacokinetics
    Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics0.50
    Taxane Pathway, Pharmacokinetics0.30


    Find genes that share SuperPaths with SLCO1B3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for SLCO1B3
        Recycling of bile acids and salts
    Transport of organic anions

    Selected PharmGKB Pathways for SLCO1B3 (see all 9)
        Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
    Fluvastatin Pathway, Pharmacokinetics
    Ibuprofen Pathway, Pharmacokinetics
    Methotrexate Pathway, Pharmacokinetics
    Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics

    1 Kegg Pathway  (Kegg details for SLCO1B3):
        Bile secretion

        Pathway & Disease-focused RT2 Profiler PCR Array including SLCO1B3: 
              Drug Transporters in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLCO1B3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLCO1B3 (ENSP000002611964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCB11ENSP000002638174STRING: ENSP00000263817
    ABCC3ENSP000002852384STRING: ENSP00000285238
    ALBENSP000002958974STRING: ENSP00000295897
    FABP6ENSP000003775494STRING: ENSP00000377549
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0008206bile acid metabolic process TAS--
    GO:0015711organic anion transport TAS10779507
    GO:0015721bile acid and bile salt transport TAS--
    GO:0043252sodium-independent organic anion transport TAS--

    Find genes that share ontologies with SLCO1B3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLCO1B3 (SO1B3)

    Selected HMDB Compounds for SLCO1B3 (see all 85)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acidChenodeoxycholic acid 3-glucuronide (see all 3)58814-71-4--
    1,3,12-Trihydroxycholan-24-oic acid1,3,12-Trihydroxycholan-24-oate (see all 6)63266-91-1--
    1,3,7,12-Tetrahydroxycholan-24-oic acid1,3,7,12-Tetrahydroxycholan-24-oate (see all 10)63266-89-7--
    12-Ketodeoxycholic acid12-Dehydrodeoxycholate (see all 20)5130-29-0--
    12a-Hydroxy-3-oxocholadienic acid12a-Hydroxy-3-oxo-4,6-choladien-24-oate (see all 8)13535-96-1--
    12b-Hydroxy-5b-cholanoic acid12b-Hydroxy-5b-cholanic acid (see all 9)15173-23-6--
    1b,3a,12a-Trihydroxy-5b-cholanoic acid1,3,12-trihydroxy-(5b)-Cholan-24-oate (see all 6)80434-32-8--
    1b,3a,7a-Trihydroxy-5b-cholanoic acid1 beta,3a,7a-Trihydroxy-5b-cholanoate (see all 18)99598-04-6--
    1b-Hydroxycholic acid1b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 5)80875-94-1--
    2b,3a,7a,12a-Tetrahydroxy-5b-cholanoic acid2b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 7)60696-60-8--

    Selected DrugBank Compounds for SLCO1B3 (see all 29)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Conjugated EstrogensEstrogens (see all 10)438-67-5transportersubstrate11159893 15159445 14977862 11134001
    RifampinRFP (see all 3)13292-46-1transportersubstrate inhibitor12085361 11641421 11134001
    Taurocholic Acid-- 81-24-3transportersubstrate11375950 11159893 11134001
    LiothyronineL-Liothyronine (see all 5)6893-02-3transportersubstrate11375950 11159893
    Liotrix-- 8065-29-0transportersubstrate11375950 11159893
    Mycophenolate mofetilMMF (see all 4)128794-94-5transportersubstrate21142914 17906856
    Valsartan-- 137862-53-4transportersubstrate19937834 19936896
    Atorvastatin-- 134523-00-5transportersubstrate23121773
    Caspofungin-- 179463-17-3transportersubstrate15716364
    Cholic Acid-- 81-25-4transportersubstrate11134001

    9 IUPHAR Ligands for SLCO1B3 (OATP1B3)    About this table
    LigandTypeActionAffinityPubmed IDs
    gemfibrozil
    InhibitorInhibition--
    rifampicin
    InhibitorInhibition--
    [3H]CCK-8 (human, mouse, rat)
    NoneNone--
    cyclosporin A
    InhibitorInhibition--
    [3H]BSP
    NoneNone--
    sildenafil
    InhibitorInhibition--
    rifamycin SV
    InhibitorInhibition--
    [3H]estradiol-17beta-glucuronide
    NoneNone--
    glycyrrhizin
    InhibitorInhibition--

    8 Novoseek inferred chemical compound relationships for SLCO1B3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oatp 88.7 3 17823233 (1), 19074973 (1)
    bromosulfophthalein 79.8 3 19881253 (1), 18314419 (1), 15226676 (1)
    taurocholate 76 3 15841457 (1), 19074973 (1)
    estrone sulfate 64.9 1 15159445 (1)
    chenodeoxycholic acid 62 2 16741617 (1), 16534140 (1)
    deoxycholic acid 47.3 2 16741617 (1), 16534140 (1)
    rifampicin 22.5 1 16837569 (1)
    cyclosporin a 1.33 1 15665139 (1)

    5 PharmGKB related drug/compound annotations for SLCO1B3 gene    About this table
    Drug/compound PharmGKB Annotation
    crizotinib
    dabrafenib
    docetaxelCA  
    mycophenolate mofetilCA  
    simeprevir



    Find genes that share compounds with SLCO1B3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLCO1B3 gene: 
    NM_019844.3  

    Unigene Cluster for SLCO1B3:

    Solute carrier organic anion transporter family, member 1B3
    Hs.504966  [show with all ESTs]
    Unigene Representative Sequence: NM_019844
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540853 ENST00000381545(uc001rel.3) ENST00000545880 ENST00000544370
    ENST00000553473 ENST00000261196(uc001rek.3)
    miRNA
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    hsa-miR-607
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    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat SLCO1B3

    Additional mRNA sequence: 

    AB669023.1 AF187815.1 AJ251506.1 AK055874.1 AY342017.1 BC022843.1 BC058006.1 BC070264.1 
    BC105597.1 

    6 DOTS entries:

    DT.101981096  DT.75197718  DT.92431202  DT.92431206  DT.70104685  DT.91655560 

    Selected AceView cDNA sequences (see all 49):

    BG616856 AI270220 BM968322 CR594924 BC022843 AF187815 CB161997 AI678477 
    CB162237 BC070264 BG563594 BC058006 BX094205 BG563836 BG569268 BG567966 
    BX497794 BX410159 BU633737 CA311212 AY342017 AV681834 AJ251506 NM_019844 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLCO1B3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAGTTGTA
    SLCO1B3 Expression
    About this image


    SLCO1B3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
    SLCO1B3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLCO1B3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.504966

    UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5
    Tissue specificity: Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the
    central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon,
    pancreas, liver and gall bladder

        Pathway & Disease-focused RT2 Profiler PCR Array including SLCO1B3: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLCO1B3 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slco1b21 , 5 solute carrier organic anion transporter family, member 1b2 less1, 5 75.88(n)1
    67.11(a)1
      6 (72.57 cM)5
    282531  NM_020495.11  NP_065241.11 
     1416295185 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    39(a)
    1 → many
    1(65382381-65399776)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    36(a)
    1 → many
    5(8325221-8353497)


    ENSEMBL Gene Tree for SLCO1B3 (if available)
    TreeFam Gene Tree for SLCO1B3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLCO1B3 gene
    SLCO2A12  SLCO4C12  SLCO1B72  ENSG000002570622  SLCO3A12  SLCO2B12  SLCO5A12  SLCO1B12  
    SLCO6A12  SLCO1A22  ENSG000002570462  SLCO4A12  SLCO1C12  
    14 SIMAP similar genes for SLCO1B3 using alignment to 5 protein entries:     SO1B3_HUMAN (see all proteins):
    SLC21A8    LST3    SLCO1B1    SLCO1B7    SLCO1C1    SLCO1A2
    DKFZp313M176    SLCO3A1    SLCO2B1    SLCO2A1    SLCO4C1    SLCO4A1
    SLCO5A1    SLCO6A1

    Find genes that share paralogs with SLCO1B3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLCO1B3 (see all 3086)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364114
    A colorectal cancer sample4--see VAR_0364112 M L mis40--------
    VAR_0364104
    A colorectal cancer sample4--see VAR_0364102 I M mis40--------
    rs128191111,2
    --20740881(+) aaaaaA/Taaaaa 1 -- int10--------
    rs1113355751,2
    C--20746769(+) GAACTG/-GGCTG 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs351830471,2
    C--20752208(+) TTTTTT/-ATAAT 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs340822391,2
    C,F--20753551(+) ATTTCT/-TTTTT 1 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs1437417111,2
    C--20758935(+) AAAAA-/ATTATTAT 1 -- cds10--------
    rs722965021,2
    C--20759653(+) TATAT-/ACATACA 1 -- int10--------
    rs346265011,2
    C--20759719(+) ATGTA-/ATTT  
            
    ATTTA
    1 -- int10--------
    rs1469904741,2
    C--20759874(+) CAATA-/TATG  
            
    TATAT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for SLCO1B3 (20963636 - 21213636 bp, first 250kb of SLCO1B3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLCO1B3 (see all 32):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663290CNV Deletion23128226
    esv2672824CNV Deletion23128226
    esv2666827CNV Deletion23128226
    nsv509459CNV Insertion20534489
    nsv636CNV Insertion18451855
    esv271083CNV Insertion20981092
    nsv898860CNV Loss21882294
    nsv898874CNV Loss21882294
    nsv898869CNV Loss21882294
    nsv898868CNV Loss21882294

    Human Gene Mutation Database (HGMD): SLCO1B3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLCO1B3
    DNA2.0 Custom Variant and Variant Library Synthesis for SLCO1B3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605495   
    OMIM disorders: 237450  
    UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5
  • Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An autosomal recessive form of primary conjugated
    hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth
    or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and
    prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 2 diseases for SLCO1B3:    
    About MalaCards
    hyperbilirubinemia, rotor type, digenic    rotor syndrome


    Find genes that share disorders with SLCO1B3           About GenesLikeMe

    3 Novoseek inferred disease relationships for SLCO1B3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 1 6 14739090 (2), 12695556 (2)
    tumors 0 1 17308056 (1)
    cancer 0 3 20130966 (2), 17186002 (1)

    Genetic Association Database (GAD): SLCO1B3
    Human Genome Epidemiology (HuGE) Navigator: SLCO1B3 (29 documents)

    Export disorders for SLCO1B3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLCO1B3 gene, integrated from 10 sources (see all 132):
    (articles sorted by number of sources associating them with SLCO1B3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. (PubMed id 11375950)1, 2, 7, 9 Abe T.... Matsuno S. (Gastroenterology 2001)
    2. Pharmacogenetic pathway analysis of docetaxel elimination. (PubMed id 18509327)1, 4, 7 Baker S.D....Sparreboom A. (Clin. Pharmacol. Ther. 2009)
    3. Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. (PubMed id 15159445)1, 7, 9 Hirano M....Sugiyama Y. (J. Pharmacol. Exp. Ther. 2004)
    4. Influence of SLCO1B3 gene polymorphism on the pharmacokinetics of digoxin in terminal renal failure. (PubMed id 19122334)1, 4, 9 Tsujimoto M....Sawada Y. (Drug Metab. Pharmacokinet. 2008)
    5. Variants in the SLCO1B3 gene: interethnic distribution and association with paclitaxel pharmacokinetics. (PubMed id 17186002)1, 4, 9 Smith N.F....Sparreboom A. (Clin. Pharmacol. Ther. 2007)
    6. Influence of solute carriers on the pharmacokinetics of CYP3A4 probes. (PubMed id 18509328)1, 4, 9 Franke R.M....Sparreboom A. (Clin. Pharmacol. Ther. 2008)
    7. Visualization of hepatic uptake transporter function in healthy subjects by using gadoxetic acid-enhanced MR imaging. (PubMed id 22771883)1, 7 Nassif A....KA1hn J.P. (Radiology 2012)
    8. Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. (PubMed id 22232210)1, 2 van de Steeg E.... Schinkel A.H. (J. Clin. Invest. 2012)
    9. Effects of tuberculosis, race, and human gene SLCO1B1 polymorphisms on rifampin concentrations. (PubMed id 20660695)1, 4 Weiner M....Vernon A. (Antimicrob. Agents Chemother. 2010)
    10. The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics. (PubMed id 19890249)1, 4 Picard N....Marquet P. (Clin. Pharmacol. Ther. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 28234 HGNC: 10961 AceView: SLCO1B3 Ensembl:ENSG00000111700 euGenes: HUgn28234
    ECgene: SLCO1B3 Kegg: 28234 H-InvDB: SLCO1B3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLCO1B3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLCO1B3 gene:
    Search GeneIP for patents involving SLCO1B3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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