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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLCO1B3 Gene

protein-coding   GIFtS: 58
GCID: GC12P020963

Solute Carrier Organic Anion Transporter Family, Member...

(Previous names: solute carrier family 21 (organic anion transporter), member...)
(Previous symbol: SLC21A8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Organic Anion Transporter Family, Member 1B31 2     LST-3TM132
SLC21A81 2     LST32
Solute Carrier Family 21 (Organic Anion Transporter), Member 81 2     OATP82
Liver-Specific Organic Anion Transporter 22 3     Liver-Specific Organic Anion Transporter 3TM132
Organic Anion Transporter 82 3     Organic Anion Transporter LST-3c2
Organic Anion-Transporting Polypeptide 82 3     Solute Carrier Organic Anion Transporter Family Member 1B32
LST-22 3     LST23
OATP-82 3     OATP8,SLC21A83
OATP1B32 3     Solute Carrier Family 21 Member 83
HBLRR2     

External Ids:    HGNC: 109611   Entrez Gene: 282342   Ensembl: ENSG000001117007   OMIM: 6054955   UniProtKB: Q9NPD53   

Export aliases for SLCO1B3 gene to outside databases

Previous GC identifers: GC12P020859 GC12P020736


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLCO1B3 Gene:
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a
transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and
plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type
hyperbilirubinemia. (provided by RefSeq, Feb 2012)

GeneCards Summary for SLCO1B3 Gene: 
SLCO1B3 (solute carrier organic anion transporter family, member 1B3) is a protein-coding gene. Diseases associated with SLCO1B3 include rotor syndrome, and intrahepatic cholestasis, and among its related super-pathways are Fluvastatin Pathway, Pharmacokinetics and Methotrexate Pathway, Pharmacokinetics. GO annotations related to this gene include organic anion transmembrane transporter activity. An important paralog of this gene is SLCO2A1.

UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5
Function: Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol,
taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and
sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver

Gene Wiki entry for SLCO1B3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLCO1B3 gene promoter:
         ATF-2   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   STAT5A   POU3F2   HNF-4alpha1   PPAR-gamma1   PPAR-gamma2   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SLCO1B3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLCO1B3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12   Ensembl cytogenetic band:  12p12.2   HGNC cytogenetic band: 12p12

SLCO1B3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO1B3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P020963:  view genomic region     (about GC identifiers)

Start:
20,963,636 bp from pter      End:
21,243,040 bp from pter
Size:
279,405 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5 (See protein sequence)
Recommended Name: Solute carrier organic anion transporter family member 1B3  
Size: 702 amino acids; 77403 Da
Subcellular location: Basolateral cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for SLCO1B3: NX_Q9NPD5

Explore proteomics data for SLCO1B3 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NPD5

  • SLCO1B3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLCO1B3 Protein Expression
    REFSEQ proteins: NP_062818.1  
    ENSEMBL proteins: 
     ENSP00000442000   ENSP00000370956   ENSP00000443225   ENSP00000451758   ENSP00000261196  
    Reactome Protein details: Q9NPD5
    Human Recombinant Protein Products for SLCO1B3: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLCO1B3 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS10779507
    GO:0016020membrane ----
    GO:0016021integral to membrane ----

    SLCO1B3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: OATP1B3 
    SLCO family of organic anion transporting polypeptides

    4 InterPro protein domains:
     IPR002350 Kazal_dom
     IPR004156 OA_transporter
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9NPD5

    ProtoNet protein and cluster: Q9NPD5

    2 Blocks protein domains:
    IPB004156 Organic anion transporter polypeptide (OATP)
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5
    Similarity: Belongs to the organo anion transporter (TC 2.A.60) family
    Similarity: Contains 1 Kazal-like domain


    SLCO1B3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SO1B3_HUMAN, Q9NPD5
    Function: Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol,
    taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and
    sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005515protein binding ----
    GO:0008514organic anion transmembrane transporter activity TAS10779507
         
    SLCO1B3 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slco1b2):
     homeostasis/metabolism  liver/biliary system  mortality/aging 

    SLCO1B3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slco1b2tm1Cdk for SLCO1B3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLCO1B3 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLCO1B3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLCO1B3 

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    hsa-miR-607
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    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SLCO1B3 (NM_019844)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO1B3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLCO1B3 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
    Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics0.80
    Statin Pathway - Generalized, Pharmacokinetics0.70
    Fluvastatin Pathway, Pharmacokinetics0.80
    Ibuprofen Pathway, Pharmacokinetics0.50
    2Pravastatin Pathway, Pharmacokinetics
    Pravastatin Pathway, Pharmacokinetics0.47
    Rosuvastatin Pathway, Pharmacokinetics0.44
    Methotrexate Pathway, Pharmacokinetics0.47
    3Synthesis of bile acids and bile salts
    Bile acid and bile salt metabolism0.74
    Recycling of bile acids and salts0.35
    4SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50
    5Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/8        Reactome Pathways for SLCO1B3 (see all 8)
        Transmembrane transport of small molecules
    SLC-mediated transmembrane transport
    Transport of vitamins, nucleosides, and related molecules
    Bile acid and bile salt metabolism
    Metabolism

    5/9 PharmGKB Pathways for SLCO1B3 (see all 9)
        Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
    Fluvastatin Pathway, Pharmacokinetics
    Ibuprofen Pathway, Pharmacokinetics
    Methotrexate Pathway, Pharmacokinetics
    Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics

    1         Kegg Pathway  (Kegg details for SLCO1B3):
        Bile secretion


    SLCO1B3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLCO1B3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLCO1B3 (ENSP000002611964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCB11ENSP000002638174STRING: ENSP00000263817
    ABCC3ENSP000002852384STRING: ENSP00000285238
    ALBENSP000002958974STRING: ENSP00000295897
    FABP6ENSP000003775494STRING: ENSP00000377549
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0008206bile acid metabolic process TAS--
    GO:0015711organic anion transport TAS10779507
    GO:0015721bile acid and bile salt transport TAS--
    GO:0043252sodium-independent organic anion transport TAS--

    SLCO1B3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLCO1B3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLCO1B3 (SO1B3)

    10/85 HMDB Compounds for SLCO1B3 (see all 85)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acidChenodeoxycholic acid 3-glucuronide (see all 3)58814-71-4--
    1,3,12-Trihydroxycholan-24-oic acid1,3,12-Trihydroxycholan-24-oate (see all 6)63266-91-1--
    1,3,7,12-Tetrahydroxycholan-24-oic acid1,3,7,12-Tetrahydroxycholan-24-oate (see all 10)63266-89-7--
    12-Ketodeoxycholic acid12-Dehydrodeoxycholate (see all 20)5130-29-0--
    12a-Hydroxy-3-oxocholadienic acid12a-Hydroxy-3-oxo-4,6-choladien-24-oate (see all 8)13535-96-1--
    12b-Hydroxy-5b-cholanoic acid12b-Hydroxy-5b-cholanic acid (see all 9)15173-23-6--
    1b,3a,12a-Trihydroxy-5b-cholanoic acid1,3,12-trihydroxy-(5b)-Cholan-24-oate (see all 6)80434-32-8--
    1b,3a,7a-Trihydroxy-5b-cholanoic acid1 beta,3a,7a-Trihydroxy-5b-cholanoate (see all 18)99598-04-6--
    1b-Hydroxycholic acid1b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 5)80875-94-1--
    2b,3a,7a,12a-Tetrahydroxy-5b-cholanoic acid2b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 7)60696-60-8--

    10/29 DrugBank Compounds for SLCO1B3 (see all 29)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Conjugated EstrogensEstrogens (see all 10)438-67-5transportersubstrate11159893 15159445 14977862 11134001
    RifampinRFP (see all 3)13292-46-1transportersubstrate inhibitor12085361 11641421 11134001
    Taurocholic Acid-- 81-24-3transportersubstrate11375950 11159893 11134001
    LiothyronineL-Liothyronine (see all 5)6893-02-3transportersubstrate11375950 11159893
    Liotrix-- 8065-29-0transportersubstrate11375950 11159893
    Mycophenolate mofetilMMF (see all 4)128794-94-5transportersubstrate21142914 17906856
    Valsartan-- 137862-53-4transportersubstrate19937834 19936896
    Atorvastatin-- 134523-00-5transportersubstrate23121773
    Caspofungin-- 179463-17-3transportersubstrate15716364
    Cholic Acid-- 81-25-4transportersubstrate11134001

    9 IUPHAR Ligands for SLCO1B3 (OATP1B3)    About this table 
    LigandTypeActionAffinityPubmed IDs
    gemfibrozil
    InhibitorInhibition--
    rifampicin
    InhibitorInhibition--
    [3H]CCK-8 (human, mouse, rat)
    NoneNone--
    cyclosporin A
    InhibitorInhibition--
    [3H]BSP
    NoneNone--
    sildenafil
    InhibitorInhibition--
    rifamycin SV
    InhibitorInhibition--
    [3H]estradiol-17β-glucuronide
    NoneNone--
    glycyrrhizin
    InhibitorInhibition--

    8 Novoseek inferred chemical compound relationships for SLCO1B3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oatp 88.7 3 17823233 (1), 19074973 (1)
    bromosulfophthalein 79.8 3 19881253 (1), 18314419 (1), 15226676 (1)
    taurocholate 76 3 15841457 (1), 19074973 (1)
    estrone sulfate 64.9 1 15159445 (1)
    chenodeoxycholic acid 62 2 16741617 (1), 16534140 (1)
    deoxycholic acid 47.3 2 16741617 (1), 16534140 (1)
    rifampicin 22.5 1 16837569 (1)
    cyclosporin a 1.33 1 15665139 (1)

    2 PharmGKB related drug/compound annotations for SLCO1B3 gene    About this table
    Drug/compound PharmGKB Annotation
    docetaxelCA  
    mycophenolate mofetilCA  

    Search CenterWatch for drugs/clinical trials and news about SLCO1B3 / SO1B3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLCO1B3 gene: 
    NM_019844.3  

    Unigene Cluster for SLCO1B3:

    Solute carrier organic anion transporter family, member 1B3
    Hs.504966  [show with all ESTs]
    Unigene Representative Sequence: NM_019844
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540853 ENST00000381545(uc001rel.3) ENST00000545880 ENST00000544370
    ENST00000553473 ENST00000261196(uc001rek.3)
    miRNA
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    GenScript: all cDNA clones in your preferred vector: SLCO1B3 (NM_019844)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLCO1B3
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    Additional mRNA sequence: 

    AB669023.1 AF187815.1 AJ251506.1 AK055874.1 AY342017.1 BC022843.1 BC058006.1 BC070264.1 
    BC105597.1 

    6 DOTS entries:

    DT.101981096  DT.75197718  DT.92431202  DT.92431206  DT.70104685  DT.91655560 

    24/49 AceView cDNA sequences (see all 49):

    BC022843 AI270220 BG616856 CR594924 BM968322 AF187815 CB161997 NM_019844 
    BX410159 BX094205 BC070264 CA311212 AV681834 BC058006 AK055874 BU633737 
    BX497794 AJ251506 BG567966 CB162237 AI678477 AY342017 BG563594 BG569268 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLCO1B3 expression in normal human tissues (normalized intensities)      SLCO1B3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAGTTGTA
    SLCO1B3 Expression
    About this image


    SLCO1B3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule

    See SLCO1B3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLCO1B3

    SOURCE GeneReport for Unigene cluster: Hs.504966

    UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5
    Tissue specificity: Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the
    central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon,
    pancreas, liver and gall bladder

        SABiosciences Expression via Pathway-Focused PCR Array including SLCO1B3: 
              Drug Transporters in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLCO1B3 gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slco1b21 , 5 solute carrier organic anion transporter family, member 1b2 less1, 5 75.88(n)1
    67.11(a)1
      6 (72.57 cM)5
    282531  NM_020495.11  NP_065241.11 
     1416295185 
    chicken
    (Gallus gallus)
    Aves SLCO1B36
    --
    --
    46(a)
    41(a)
    1 ↔ many
    possible ortholog
    1(65317306-65337388)
    1(65337214-65368820)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    46(a)
    43(a)
    1 ↔ many
    possible ortholog
    5(8410455-8428198)
    5(8382878-8408937)
    zebrafish
    (Danio rerio)
    Actinopterygii slco1d16
    slco1c16
    (see all 8)
    solute carrier organic anion transporter family, m...
    solute carrier organic anion transporter family, m...
    (see all 8)
    44(a)
    43(a)
    (see all 8)
    possible ortholog
    1 ↔ many
    (see all 8)
    Zv9_NA995(3331-39201)
    4(2545908-2598583)
    fruit fly
    (Drosophila melanogaster)
    Insecta Oatp33Ea6
    Oatp58Dc6
    (see all 6)
    Organic anion transporting polypeptide 58Dc
    (see all 6)
    22(a)
    21(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    2L(12441401-12445924)
    2R(18111186-18116073)
    worm
    (Caenorhabditis elegans)
    Secernentea F21G4.16
    F47E1.46
    (see all 4)
    Protein F47E1.4
    (see all 4)
    24(a)
    22(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    X(9889315-9892328)
    X(9062834-9066657)


    ENSEMBL Gene Tree for SLCO1B3 (if available)
    TreeFam Gene Tree for SLCO1B3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLCO1B3 gene
    SLCO2A12  SLCO4C12  SLCO1B72  ENSG000002570622  SLCO3A12  SLCO2B12  SLCO5A12  SLCO1B12  
    SLCO6A12  SLCO1A22  ENSG000002570462  SLCO4A12  SLCO1C12  
    14 SIMAP similar genes for SLCO1B3 using alignment to 5 protein entries:     SO1B3_HUMAN (see all proteins):
    SLC21A8    LST3    SLCO1B1    SLCO1B7    SLCO1C1    SLCO1A2
    DKFZp313M176    SLCO3A1    SLCO2B1    SLCO2A1    SLCO4C1    SLCO4A1
    SLCO5A1    SLCO6A1

    SLCO1B3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3086 SNPs in SLCO1B3 are shown (see all 3086)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364114
    A colorectal cancer sample4--see VAR_0364112 M L mis40--------
    VAR_0364104
    A colorectal cancer sample4--see VAR_0364102 I M mis40--------
    rs128191111,2
    --20740881(+) aaaaaA/Taaaaa 1 -- int10--------
    rs1113355751,2
    C--20746769(+) GAACTG/-GGCTG 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs351830471,2
    C--20752208(+) TTTTTT/-ATAAT 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs340822391,2
    C,F--20753551(+) ATTTCT/-TTTTT 1 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs1437417111,2
    C--20758935(+) AAAAA-/ATTATTAT 1 -- cds10--------
    rs722965021,2
    C--20759653(+) TATAT-/ACATACA 1 -- int10--------
    rs346265011,2
    C--20759719(+) ATGTA-/ATTT  
            
    ATTTA
    1 -- int10--------
    rs1469904741,2
    C--20759874(+) CAATA-/TATG  
            
    TATAT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for SLCO1B3 (20963636 - 21213636 bp, first 250kb of SLCO1B3)

    Structural Variations
         Database of Genomic Variants (DGV) 10/32 variations for SLCO1B3 (see all 32):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2663290CNV Deletion23128226
    esv2672824CNV Deletion23128226
    esv2666827CNV Deletion23128226
    nsv509459CNV Insertion20534489
    nsv636CNV Insertion18451855
    esv271083CNV Insertion20981092
    nsv898860CNV Loss21882294
    nsv898874CNV Loss21882294
    nsv898869CNV Loss21882294
    nsv898868CNV Loss21882294


    Human Gene Mutation Database (HGMD): SLCO1B3
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605495    OMIM disorders: --

    UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5
  • Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An autosomal recessive form of primary conjugated
    hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth
    or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and
    prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 20/25 diseases for SLCO1B3 (see all 25):    About MalaCards
    rotor syndrome    intrahepatic cholestasis    intrahepatic cholestasis of pregnancy    cholestasis
    peripheral t-cell lymphoma    leukopenia    cutaneous t cell lymphoma    jaundice
    primary biliary cirrhosis    chronic myeloid leukemia    choroiditis    hepatocellular carcinoma
    cytochrome p450    nasopharyngitis    liver disease    myeloid leukemia
    colon cancer    cerebritis    prostate cancer    tuberculosis


    SLCO1B3 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for SLCO1B3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 1 6 14739090 (2), 12695556 (2)
    tumors 0 1 17308056 (1)
    cancer 0 3 20130966 (2), 17186002 (1)

    Genetic Association Database (GAD): SLCO1B3
    Human Genome Epidemiology (HuGE) Navigator: SLCO1B3 (29 documents)

    Export disorders for SLCO1B3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLCO1B3 gene, integrated from 9 sources (see all 128):
    (articles sorted by number of sources associating them with SLCO1B3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. (PubMed id 11375950)1, 2, 7, 9 Abe T.... Matsuno S. (2001)
    2. Pharmacogenetic Pathway Analysis of Docetaxel Elimination. (PubMed id 18509327)1, 4, 7 Baker S....Sparreboom A. (2008)
    3. Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. (PubMed id 15159445)1, 7, 9 Hirano M....Sugiyama Y. (2004)
    4. Influence of SLCO1B3 gene polymorphism on the pharmacokinetics of digoxin in terminal renal failure. (PubMed id 19122334)1, 4, 9 Tsujimoto M....Sawada Y. (2008)
    5. Variants in the SLCO1B3 gene: interethnic distribution and association with paclitaxel pharmacokinetics. (PubMed id 17186002)1, 4, 9 Smith N.F....Sparreboom A. (2007)
    6. Influence of Solute Carriers on the Pharmacokinetics of CYP3A4 Probes. (PubMed id 18509328)1, 4, 9 Franke R....Sparreboom A. (2008)
    7. Visualization of hepatic uptake transporter function i n healthy subjects by using gadoxetic acid-enhanced MR imaging. (PubMed id 22771883)1, 7 Nassif A....Kuhn J.P. (2012)
    8. Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. (PubMed id 22232210)1, 2 van de Steeg E....Schinkel A.H. (2012)
    9. Effects of tuberculosis, race, and human gene SLCO1B1 polymorphisms on rifampin concentrations. (PubMed id 20660695)1, 4 Weiner M....Vernon A. (2010)
    10. The role of organic anion-transporting polypeptides a nd their common genetic variants in mycophenolic acid pharmacokinetics. (PubMed id 19890249)1, 4 Picard N....Marquet P. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28234 HGNC: 10961 AceView: SLCO1B3 Ensembl:ENSG00000111700 euGenes: HUgn28234
    ECgene: SLCO1B3 Kegg: 28234 H-InvDB: SLCO1B3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLCO1B3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLCO1B3 gene:
    Search GeneIP for patents involving SLCO1B3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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