Aliases for SLCO1B3 Gene
External Ids for SLCO1B3 Gene
Previous HGNC Symbols for SLCO1B3 Gene
Previous GeneCards Identifiers for SLCO1B3 Gene
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. [provided by RefSeq, Feb 2012]
GeneCards Summary for SLCO1B3 Gene
SLCO1B3 (Solute Carrier Organic Anion Transporter Family, Member 1B3) is a Protein Coding gene. Diseases associated with SLCO1B3 include hyperbilirubinemia, rotor type, digenic and ascending colon cancer. Among its related pathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and organic anion transmembrane transporter activity. An important paralog of this gene is SLCO1B7.
UniProtKB/Swiss-Prot for SLCO1B3 Gene
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.