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Aliases for SLCO1B3 Gene

Aliases for SLCO1B3 Gene

  • Solute Carrier Organic Anion Transporter Family, Member 1B3 2 3
  • SLC21A8 3 4 6
  • OATP1B3 3 4 6
  • OATP8 3 4 6
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 8 2 3
  • Liver-Specific Organic Anion Transporter 2 3 4
  • Organic Anion-Transporting Polypeptide 8 3 4
  • Organic Anion Transporter 8 3 4
  • OATP-8 3 4
  • HBLRR 3 6
  • LST-2 3 4
  • Solute Carrier Organic Anion Transporter Family Member 1B3 3
  • Liver-Specific Organic Anion Transporter 3TM13 3
  • Solute Carrier Family 21 Member 8 4
  • Organic Anion Transporter LST-3c 3
  • LST-3TM13 3
  • LST3 3
  • LST2 4

External Ids for SLCO1B3 Gene

Previous HGNC Symbols for SLCO1B3 Gene

  • SLC21A8

Previous GeneCards Identifiers for SLCO1B3 Gene

  • GC12P020859
  • GC12P020963

Summaries for SLCO1B3 Gene

Entrez Gene Summary for SLCO1B3 Gene

  • This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. [provided by RefSeq, Feb 2012]

GeneCards Summary for SLCO1B3 Gene

SLCO1B3 (Solute Carrier Organic Anion Transporter Family, Member 1B3) is a Protein Coding gene. Diseases associated with SLCO1B3 include hyperbilirubinemia, rotor type, digenic and intrahepatic cholestasis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include organic anion transmembrane transporter activity. An important paralog of this gene is SLCO1B7.

UniProtKB/Swiss-Prot for SLCO1B3 Gene

  • Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.

Gene Wiki entry for SLCO1B3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO1B3 Gene

Genomics for SLCO1B3 Gene

Genomic Location for SLCO1B3 Gene

Start:
20,810,702 bp from pter
End:
20,916,911 bp from pter
Size:
106,210 bases
Orientation:
Plus strand

Genomic View for SLCO1B3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLCO1B3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO1B3 Gene

Proteins for SLCO1B3 Gene

  • Protein details for SLCO1B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPD5-SO1B3_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 1B3
    Protein Accession:
    Q9NPD5
    Secondary Accessions:
    • E7EMT8
    • Q5JAR4

    Protein attributes for SLCO1B3 Gene

    Size:
    702 amino acids
    Molecular mass:
    77403 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLCO1B3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLCO1B3 Gene

Proteomics data for SLCO1B3 Gene at MOPED

Post-translational modifications for SLCO1B3 Gene

Other Protein References for SLCO1B3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLCO1B3 Gene

Domains for SLCO1B3 Gene

Gene Families for SLCO1B3 Gene

Suggested Antigen Peptide Sequences for SLCO1B3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NPD5

UniProtKB/Swiss-Prot:

SO1B3_HUMAN :
  • Q9NPD5
Domain:
  • Contains 1 Kazal-like domain.
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO1B3: view

Function for SLCO1B3 Gene

Molecular function for SLCO1B3 Gene

UniProtKB/Swiss-Prot Function: Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.

Gene Ontology (GO) - Molecular Function for SLCO1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005515 protein binding --
GO:0008514 organic anion transmembrane transporter activity TAS 10779507
genes like me logo Genes that share ontologies with SLCO1B3: view

Phenotypes for SLCO1B3 Gene

genes like me logo Genes that share phenotypes with SLCO1B3: view

Animal Models for SLCO1B3 Gene

MGI Knock Outs for SLCO1B3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLCO1B3 Gene

Localization for SLCO1B3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO1B3 Gene

Basolateral cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLCO1B3 Gene COMPARTMENTS Subcellular localization image for SLCO1B3 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLCO1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10779507
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with SLCO1B3: view

Pathways for SLCO1B3 Gene

genes like me logo Genes that share pathways with SLCO1B3: view

Interacting Proteins for SLCO1B3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000261196%0d%0a9606.ENSP00000285238%0d%0a9606.ENSP00000377549%0d%0a9606.ENSP00000295897%0d%0a
Selected Interacting proteins: ENSP00000261196 for SLCO1B3 Gene via STRING

Gene Ontology (GO) - Biological Process for SLCO1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0008206 bile acid metabolic process TAS --
GO:0015711 organic anion transport TAS 10779507
GO:0015721 bile acid and bile salt transport TAS --
GO:0043252 sodium-independent organic anion transport TAS --
genes like me logo Genes that share ontologies with SLCO1B3: view

Compounds for SLCO1B3 Gene

(85) HMDB Compounds for SLCO1B3 Gene

Compound Synonyms Cas Number PubMed IDs
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
58814-71-4
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-oate
63266-91-1
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-oate
63266-89-7
12a-Hydroxy-3-oxocholadienic acid
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oate
13535-96-1
12b-Hydroxy-5b-cholanoic acid
  • 12b-Hydroxy-5b-cholanic acid
15173-23-6

(29) Drugbank Compounds for SLCO1B3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Atorvastatin
134523-00-5 transporter substrate
Cabazitaxel
  • RPR-116258A
183133-96-2 transporter inhibitor
Caspofungin
179463-17-3 transporter substrate
Cholic Acid
81-25-4 transporter substrate
Conjugated Estrogens
  • Estrogens
438-67-5 transporter substrate

(9) IUPHAR Ligand for SLCO1B3 Gene

Ligand Type Action Affinity Pubmed IDs
gemfibrozil Inhibitor Inhibition
rifampicin Inhibitor Inhibition
[3H]CCK-8 (human, mouse, rat) None None
cyclosporin A Inhibitor Inhibition
[3H]BSP None None
sildenafil Inhibitor Inhibition
rifamycin SV Inhibitor Inhibition
[3H]estradiol-17beta-glucuronide None None
glycyrrhizin Inhibitor Inhibition

(8) Novoseek inferred chemical compound relationships for SLCO1B3 Gene

Compound -log(P) Hits PubMed IDs
oatp 88.7 2
bromosulfophthalein 79.8 3
taurocholate 76 2
estrone sulfate 64.9 1
chenodeoxycholic acid 62 2

(5) PharmGKB related drug/compound annotations for SLCO1B3 Gene

genes like me logo Genes that share compounds with SLCO1B3: view

Transcripts for SLCO1B3 Gene

Unigene Clusters for SLCO1B3 Gene

Solute carrier organic anion transporter family, member 1B3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO1B3 Gene

No ASD Table

Relevant External Links for SLCO1B3 Gene

GeneLoc Exon Structure for
SLCO1B3
ECgene alternative splicing isoforms for
SLCO1B3

Expression for SLCO1B3 Gene

mRNA expression in normal human tissues for SLCO1B3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO1B3 Gene

This gene is overexpressed in Liver (47.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLCO1B3 Gene

SOURCE GeneReport for Unigene cluster for SLCO1B3 Gene Hs.504966

mRNA Expression by UniProt/SwissProt for SLCO1B3 Gene

Q9NPD5-SO1B3_HUMAN
Tissue specificity: Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder
genes like me logo Genes that share expressions with SLCO1B3: view

Orthologs for SLCO1B3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLCO1B3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 70 (a)
OneToMany
SLCO1B3 35
  • 80.9 (n)
  • 71.49 (a)
dog
(Canis familiaris)
Mammalia OATPC 36
  • 71 (a)
OneToMany
SLCO1B3 35
  • 81.88 (n)
  • 71.59 (a)
mouse
(Mus musculus)
Mammalia Slco1b2 35
  • 75.88 (n)
  • 67.11 (a)
Slco1b2 16
Slco1b2 36
  • 66 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slco1b2 35
  • 75.46 (n)
  • 65.4 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 39 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
OneToMany
Species with no ortholog for SLCO1B3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLCO1B3 Gene

ENSEMBL:
Gene Tree for SLCO1B3 (if available)
TreeFam:
Gene Tree for SLCO1B3 (if available)

Paralogs for SLCO1B3 Gene

genes like me logo Genes that share paralogs with SLCO1B3: view

Variants for SLCO1B3 Gene

Sequence variations from dbSNP and Humsavar for SLCO1B3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs975653 -- 20,845,926(+) aatct(C/T)ttttt intron-variant
rs975654 -- 20,846,046(+) tctta(C/T)atcag intron-variant
rs975655 -- 20,846,134(+) acttc(C/T)tttgg intron-variant
rs975656 -- 20,846,147(+) ACATT(C/T)ACTAT intron-variant
rs975657 -- 20,846,411(+) ACTTC(A/G)TTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO1B3 Gene

Variant ID Type Subtype PubMed ID
esv24973 CNV Gain 19812545
dgv481e1 CNV Complex 17122850
nsv428275 CNV Gain 18775914
nsv483093 CNV Loss 15286789
nsv898859 CNV Gain 21882294
nsv898860 CNV Loss 21882294
esv2750761 CNV Loss 17666407
dgv4e24 CNV Loss 17666407
dgv276n67 CNV Gain 20364138
nsv509459 CNV Insertion 20534489
dgv1387n71 CNV Loss 21882294
nsv898865 CNV Loss 21882294
nsv898866 CNV Loss 21882294
nsv898867 CNV Gain+Loss 21882294
nsv898868 CNV Loss 21882294
esv2672824 CNV Deletion 23128226
nsv898869 CNV Loss 21882294
nsv898870 CNV Gain+Loss 21882294
nsv898871 CNV Gain 21882294
nsv898872 CNV Loss 21882294
esv271083 CNV Insertion 20981092
dgv1388n71 CNV Gain+Loss 21882294
nsv898874 CNV Loss 21882294
nsv898875 CNV Loss 21882294
esv2663290 CNV Deletion 23128226
nsv515735 CNV Gain+Loss 19592680
esv2666827 CNV Deletion 23128226
nsv8927 CNV Gain 18304495
nsv8928 CNV Loss 18304495
nsv636 CNV Insertion 18451855
nsv898877 CNV Loss 21882294
nsv438195 CNV Loss 16468122

Relevant External Links for SLCO1B3 Gene

HapMap Linkage Disequilibrium report
SLCO1B3
Human Gene Mutation Database (HGMD)
SLCO1B3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO1B3 Gene

Disorders for SLCO1B3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SLCO1B3 Gene including...

Search for SLCO1B3 Gene in MalaCards »

(1) OMIM Diseases for SLCO1B3 Gene (605495)

UniProtKB/Swiss-Prot

SO1B3_HUMAN
  • Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. {ECO:0000269 PubMed:22232210}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) Novoseek inferred disease relationships for SLCO1B3 Gene

Disease -log(P) Hits PubMed IDs
hepatocellular carcinoma 1 4
tumors 0 1
cancer 0 3

Relevant External Links for SLCO1B3

Genetic Association Database (GAD)
SLCO1B3
Human Genome Epidemiology (HuGE) Navigator
SLCO1B3
genes like me logo Genes that share disorders with SLCO1B3: view

Publications for SLCO1B3 Gene

  1. LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. (PMID: 11375950) Abe T. … Matsuno S. (Gastroenterology 2001) 3 4 23 25
  2. Variants in the SLCO1B3 gene: interethnic distribution and association with paclitaxel pharmacokinetics. (PMID: 17186002) Smith N.F. … Sparreboom A. (Clin. Pharmacol. Ther. 2007) 3 23 48
  3. Influence of solute carriers on the pharmacokinetics of CYP3A4 probes. (PMID: 18509328) Franke R.M. … Sparreboom A. (Clin. Pharmacol. Ther. 2008) 3 23 48
  4. Influence of SLCO1B3 gene polymorphism on the pharmacokinetics of digoxin in terminal renal failure. (PMID: 19122334) Tsujimoto M. … Sawada Y. (Drug Metab. Pharmacokinet. 2008) 3 23 48
  5. Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. (PMID: 15159445) Hirano M. … Sugiyama Y. (J. Pharmacol. Exp. Ther. 2004) 3 23 25

Products for SLCO1B3 Gene

  • antibodies-online peptides for SLCO1B3
  • antibodies-online antibodies for SLCO1B3
  • antibodies-online kits for SLCO1B3

Sources for SLCO1B3 Gene

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