Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLCO1B3 Gene

protein-coding GIFtS: 55
GCID: GC12P020963

solute carrier organic anion transporter family, member...

(Previous names: solute carrier family 21 (organic anion transporter), member...)
(Previous symbol: SLC21A8)

Explore 25 diseases affiliated with
SLCO1B3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Organic Anion Transporter Family, Member 1B3¹ ²		HBLRR²
OATP1B3¹ ² ³		LST-3TM13²
OATP8¹ ²		LST3²
SLC21A8¹ ²		Liver-Specific Organic Anion Transporter 3TM13²
Solute Carrier Family 21 (Organic Anion Transporter), Member 8¹ ²		Organic Anion Transporter LST-3c²
Liver-Specific Organic Anion Transporter 2² ³		Solute Carrier Organic Anion Transporter Family Member 1B3²
Organic Anion Transporter 8² ³		LST2³
Organic Anion-Transporting Polypeptide 8² ³		OATP8,SLC21A8³
LST-2² ³		Solute Carrier Family 21 Member 8³
OATP-8² ³

External Ids:	HGNC: 10961¹	Entrez Gene: 28234²	Ensembl: ENSG00000111700⁷	OMIM: 605495⁵	UniProtKB: Q9NPD5³

Export aliases for SLCO1B3 gene to outside databases

Previous GC identifers: GC12P020859 GC12P020736

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLCO1B3:

This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a

transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a

critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type

hyperbilirubinemia. (provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5

Function: Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate,

triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein

(BSP). Involved in the clearance of bile acids and organic anions from the liver

Gene Wiki entry for SLCO1B3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLCO1B3 gene promoter:
ATF-2 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) STAT5A POU3F2 HNF-4alpha1 PPAR-gamma1 PPAR-gamma2 aMEF-2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for SLCO1B3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLCO1B3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12 Ensembl cytogenetic band: 12p12.2 HGNC cytogenetic band: 12p12

SLCO1B3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO1B3 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P020963: view genomic region (about GC identifiers)

Start:	20,963,636 bp from pter	End:	21,243,040 bp from pter
Size:	279,405 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5 (See protein sequence)

Recommended Name: Solute carrier organic anion transporter family member 1B3

Size: 702 amino acids; 77403 Da

Subcellular location: Basolateral cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for SLCO1B3: NX_Q9NPD5

Post-translational modifications:

N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NPD5

SLCO1B3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_062818.1

ENSEMBL proteins:

ENSP00000442000 ENSP00000370956 ENSP00000442769 ENSP00000443225 ENSP00000451758

ENSP00000261196

Reactome Protein details: Q9NPD5
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: SLCO1B3 OriGene Custom Protein Services for SLCO1B3
	GenScript Custom Purified and Recombinant Proteins Services for SLCO1B3
	Novus Biologicals SLCO1B3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLCO1B3

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	10779507
GO:0016020	membrane	--	--
GO:0016323	basolateral plasma membrane	IEA	--

SLCO1B3 for ontologies About GeneDecksing

SLCO1B3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SLCO1B3
	GenScript Custom Superior Antibodies Services for SLCO1B3
	Novus Biologicals SLCO1B3 Antibody
	Search for Antibodies for SLCO1B3 at Abcam
	Uscn Antibodies for SLCO1B3
	ThermoFisher Antibody for SLCO1B3

Assay Products for SLCO1B3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SLCO1B3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SLCO1B3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLCO1B3 for domains About GeneDecksing

5 InterPro domains/families:

IPR002350 Prot_inh_Kazal

IPR004156 OA_transporter

IPR020846 MFS_dom

IPR011497 Kazal-type_dom

IPR016196 MFS_dom_general_subst_transpt

Graphical View of Domain Structure for InterPro Entry Q9NPD5

ProtoNet protein and cluster: Q9NPD5

2 Blocks protein families:

IPB004156 Organic anion transporter polypeptide (OATP)

IPB011497 Protease inhibitor

UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5

Similarity: Belongs to the organo anion transporter (TC 2.A.60) family

Similarity: Contains 1 Kazal-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5

Function: Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate,

triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein

(BSP). Involved in the clearance of bile acids and organic anions from the liver

miRNA Products:		OriGene 3'-UTR Clone: SLCO1B3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLCO1B3
		1 QIAGEN miScript miRNA Assays for microRNA that regulate SLCO1B3:
		hsa-miR-607
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLCO1B3 (see all 4) OriGene shRNA RFP: SLCO1B3 OriGene siRNA: SLCO1B3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLCO1B3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SLCO1B3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLCO1B3 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLCO1B3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SLCO1B3 (NM_019844)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLCO1B3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLCO1B3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SLCO1B3
		Search LifeMap BioReagents cell lines for SLCO1B3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO1B3

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	--	--
GO:0008514	organic anion transmembrane transporter activity	TAS	10779507

SLCO1B3 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Slco1b2^tm1Cdk for SLCO1B3
     3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slco1b2):

homeostasis/metabolism

liver/biliary system

mortality/aging

SLCO1B3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics

	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics	1.00			Statin Pathway - Generalized, Pharmacokinetics	0.70
	Fluvastatin Pathway, Pharmacokinetics	0.80

Pravastatin Pathway, Pharmacokinetics

	Pravastatin Pathway, Pharmacokinetics	1.00			Rosuvastatin Pathway, Pharmacokinetics	0.44
	Methotrexate Pathway, Pharmacokinetics	0.47

Transport of organic anions

Transport of organic anions

1.00

Transport of vitamins, nucleosides, and related molecules

0.35

SLC-mediated transmembrane transport

SLC-mediated transmembrane transport

1.00

Transmembrane transport of small molecules

0.50

Metabolism

Metabolism

1.00

Metabolism of lipids and lipoproteins

0.34

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 Reactome Pathways for SLCO1B3 (see all 8)

	Transmembrane transport of small molecules
	SLC-mediated transmembrane transport
	Transport of vitamins, nucleosides, and related molecules
	Bile acid and bile salt metabolism
	Metabolism

5/8 PharmGKB Pathways for SLCO1B3 (see all 8)

	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
	Fluvastatin Pathway, Pharmacokinetics
	Methotrexate Pathway, Pharmacokinetics
	Mycophenolic acid Pathway, Pharmacokinetics
	Pravastatin Pathway, Pharmacokinetics

1 Kegg Pathway (Kegg details for SLCO1B3):

Bile secretion

SLCO1B3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SLCO1B3

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for SLCO1B3 (ENSP00000261196⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABCB11	ENSP00000263817⁴	STRING: ENSP00000263817
ABCC3	ENSP00000285238⁴	STRING: ENSP00000285238
ALB	ENSP00000295897⁴	STRING: ENSP00000295897
FABP6	ENSP00000377549⁴	STRING: ENSP00000377549

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008206	bile acid metabolic process	TAS	--
GO:0015711	organic anion transport	TAS	10779507
GO:0015721	bile acid and bile salt transport	TAS	--
GO:0043252	sodium-independent organic anion transport	TAS	--
GO:0044281	small molecule metabolic process	TAS	--

SLCO1B3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SLCO1B3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLCO1B3

10/85 HMDB Compounds for SLCO1B3 (see all 85) About this table

Compound	Synonyms	CAS #	PubMed Ids
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid	Chenodeoxycholic acid 3-glucuronide (see all 3)	58814-71-4	--
1,3,12-Trihydroxycholan-24-oic acid	1,3,12-Trihydroxycholan-24-oate (see all 6)	63266-91-1	--
1,3,7,12-Tetrahydroxycholan-24-oic acid	1,3,7,12-Tetrahydroxycholan-24-oate (see all 10)	63266-89-7	--
12-Ketodeoxycholic acid	12-Dehydrodeoxycholate (see all 20)	5130-29-0	--
12a-Hydroxy-3-oxocholadienic acid	12a-Hydroxy-3-oxo-4,6-choladien-24-oate (see all 8)	13535-96-1	--
12b-Hydroxy-5b-cholanoic acid	12b-Hydroxy-5b-cholanic acid (see all 9)	15173-23-6	--
1b,3a,12a-Trihydroxy-5b-cholanoic acid	1,3,12-trihydroxy-(5b)-Cholan-24-oate (see all 6)	80434-32-8	--
1b,3a,7a-Trihydroxy-5b-cholanoic acid	1 beta,3a,7a-Trihydroxy-5b-cholanoate (see all 18)	99598-04-6	--
1b-Hydroxycholic acid	1b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 5)	80875-94-1	--
2b,3a,7a,12a-Tetrahydroxy-5b-cholanoic acid	2b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 7)	60696-60-8	--

10/13 DrugBank Compounds for SLCO1B3 (see all 13) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Conjugated Estrogens	Estrogens (see all 10)	438-67-5	transporter	substrate	11159893 15159445 14977862 11134001
Rifampin	RFP (see all 3)	13292-46-1	transporter	substrate inhibitor	12085361 11641421 11134001
Taurocholic Acid	--	81-24-3	transporter	substrate	11375950 11159893 11134001
Liothyronine	L-Liothyronine (see all 5)	6893-02-3	transporter	substrate	11375950 11159893
Liotrix	--	8065-29-0	transporter	substrate	11375950 11159893
Valsartan	--	137862-53-4	transporter	substrate	19937834 19936896
Caspofungin	--	179463-17-3	transporter	substrate	15716364
Cholic Acid	--	81-25-4	transporter	substrate	11134001
Digoxin	--	20830-75-5	transporter	substrate	11159893
Methotrexate	Amethopterin (see all 12)	59-05-2	transporter	substrate	11375950

8 Novoseek chemical compound relationships for SLCO1B3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
oatp	88.7	3	17823233 (1), 19074973 (1)
bromosulfophthalein	79.8	3	19881253 (1), 18314419 (1), 15226676 (1)
taurocholate	76	3	15841457 (1), 19074973 (1)
estrone sulfate	64.9	1	15159445 (1)
chenodeoxycholic acid	62	2	16741617 (1), 16534140 (1)
deoxycholic acid	47.3	2	16741617 (1), 16534140 (1)
rifampicin	22.5	1	16837569 (1)
cyclosporin a	1.33	1	15665139 (1)

2 PharmGKB related drug/compound annotations for SLCO1B3 gene

Drug/compound	PharmGKB Annotation
docetaxel	CA
mycophenolate mofetil	CA

About this table

Search CenterWatch for drugs/clinical trials and news about SLCO1B3 / SO1B3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLCO1B3 gene:

NM_019844.3

Unigene Cluster for SLCO1B3:

Solute carrier organic anion transporter family, member 1B3

Hs.504966 [show with all ESTs]

Unigene Representative Sequence: NM_019844

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000540853 ENST00000381545(uc001rel.3) ENST00000545880 ENST00000544370

ENST00000553473 ENST00000261196(uc001rek.3)

miRNA Products:		OriGene 3'-UTR Clone: SLCO1B3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLCO1B3
		1 QIAGEN miScript miRNA Assays for microRNA that regulate SLCO1B3:
		hsa-miR-607
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLCO1B3 (see all 4) OriGene shRNA RFP: SLCO1B3 OriGene siRNA: SLCO1B3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLCO1B3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLCO1B3 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLCO1B3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SLCO1B3 (NM_019844)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLCO1B3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLCO1B3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLCO1B3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SLCO1B3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLCO1B3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLCO1B3

Additional cDNA sequence:

AB669023.1 AF187815.1 AJ251506.1 AK055874.1 AY342017.1 BC022843.1 BC058006.1 BC070264.1

BC105597.1

6 DOTS entries:

DT.101981096 DT.75197718 DT.92431202 DT.92431206 DT.70104685 DT.91655560

24/49 AceView cDNA sequences (see all 49):

BM968322 BG616856 AI270220 BC022843 CR594924 AF187815 AI678477 NM_019844

AK055874 CA311212 AY342017 AJ251506 BX094205 CB161997 BX497794 BG569268

BG563594 BG545072 CB162237 BG563836 BC058006 BC070264 BU633737 AV681834

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLCO1B3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAAGTTGTA

About this image

SLCO1B3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Perivenous Hepatocytes

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLCO1B3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLCO1B3

SOURCE GeneReport for Unigene cluster: Hs.504966

UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5

Tissue specificity: Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the

central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas,

liver and gall bladder

SABiosciences Expression via Pathway-Focused PCR Array including SLCO1B3:

Drug Transporters in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLCO1B3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SLCO1B3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLCO1B3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLCO1B3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO1B3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SLCO1B3 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLCO1B3⁶	Uncharacterized protein	49(a)	1 → many	1(67328451-67343147)
lizard (Anolis carolinensis)	Reptilia	--	--	45(a)	1 → many	5(8412701-8428198)
zebrafish (Danio rerio)	Actinopterygii	slco1d1⁶ slco1f4⁶ (see all 6)	solute carrier organic anion transporter family, m... solute carrier organic anion transporter family, m... (see all 6)	44(a) 43(a) (see all 6)	1 ↔ many possible ortholog (see all 6)	Zv9_NA995(3331-39201) 4(60470768-60490279)
fruit fly (Drosophila melanogaster)	Insecta	Oatp58Da⁶ Oatp33Ea⁶ (see all 7)	Organic anion transporting polypeptide 33Ea (see all 7)	22(a) 21(a) (see all 7)	many ↔ many many ↔ many (see all 7)	2R(18105961-18108393) 2L(12441401-12445924)
worm (Caenorhabditis elegans)	Secernentea	F21G4.1⁶ F47E1.4⁶ (see all 4)	Protein F47E1.4 (see all 4)	22(a) 21(a) (see all 4)	many ↔ many many ↔ many (see all 4)	X(9889257-9892270) X(9062779-9066602)

ENSEMBL Gene Tree for SLCO1B3 (if available)
TreeFam Gene Tree for SLCO1B3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLCO1B3 gene

SLCO2A1² SLCO4C1² SLCO1B7² ENSG00000257062² SLCO3A1² SLCO5A1² SLCO2B1² SLCO6A1²

SLCO1B1² ENSG00000257046² SLCO4A1² SLCO1A2² SLCO1C1²

14 SIMAP similar genes for SLCO1B3 using alignment to 7 protein entries: SO1B3_HUMAN (see all proteins):

SLC21A8 SLCO1B1 SLCO1B7 LST3 SLCO1A2 SLCO1C1

SLCO3A1 DKFZp313M176 SLCO2B1 SLCO2A1 SLCO4C1 SLCO4A1

SLCO5A1 SLCO6A1

SLCO1B3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs71446729^1,2	C,	--	20734702(+)	`TTATTG/TCGGCA`	1	--	us2k¹		2		NA	122
rs76333049^1,2		--	20735387(+)	`ACACTC/GCGGTT`	1	--	us2k¹		0	--	--	--	--
rs114820563^1,2	C,F,	--	20735782(+)	`AAATAC/AATATT`	1	--	us2k¹		1		WA	118
rs78852732^1,2		--	20737305(+)	`CTTCTC/GGGCAC`	1	--	int¹		0	--	--	--	--
rs192060213^1,2	C,	--	20738182(+)	`CTGCTC/TCCGGC`	1	--	int¹		0	--	--	--	--
rs116708077^1,2	C,F,	--	20738661(+)	`AAGAAT/CGGACA`	1	--	int¹		1		WA	118
rs74067222^1,2	C,	--	20738864(+)	`TATAGG/AATTAA`	1	--	int¹		1		WA	2
rs76069495^1,2		--	20739490(+)	`TTGTTT/GCCATA`	1	--	int¹		1		NA	120
rs77714247^1,2	F,	--	20739984(+)	`TTTACA/CTATCT`	1	--	int¹		1		NA	120
rs76036462^1,2		--	20740001(+)	`TCTATA/GTGAGC`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for SLCO1B3 (20963636 - 21213636 bp, first 250kb of SLCO1B3)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for SLCO1B3
5 CNVs: 49020 3878 31863 0162 71474
1 Indel: 33251
Human Gene Mutation Database (HGMD): SLCO1B3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLCO1B3

DNA2.0 Custom Variant and Variant Library Synthesis for SLCO1B3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLCO1B3 for disorders About GeneDecksing

OMIM gene information: 605495 OMIM disorders: --

UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5

Defects in SLCO1B3 are a cause of hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]. An autosomal recessive

form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with

hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye

bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal

20/25 diseases for SLCO1B3 (see all 25): About MalaCards

intrahepatic cholestasis intrahepatic cholestasis of pregnancy rotor syndrome primary biliary cirrhosis

cholestasis peripheral t-cell lymphoma chronic myeloid leukemia myeloid leukemia

cutaneous t cell lymphoma leukopenia hepatocellular carcinoma liver disease

choroiditis colon cancer ovarian cancer nasopharyngitis

breast carcinoma leukemia carcinoma prostate cancer

3 Novoseek disease relationships for SLCO1B3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatocellular carcinoma	1	6	14739090 (2), 12695556 (2)
tumors	0	1	17308056 (1)
cancer	0	3	20130966 (2), 17186002 (1)

Human Genome Epidemiology (HuGE) Navigator: SLCO1B3 (29 documents)

Export disorders for SLCO1B3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLCO1B3 gene, integrated from 9 sources (see all 112):
(articles sorted by number of sources associating them with SLCO1B3)

Utopia: connect your pdf to the dynamic
world of online information

LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. (PubMed id 11375950)^{1, 2, 7, 9} Abe T.... Matsuno S. (2001)
Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. (PubMed id 15159445)^{1, 7, 9} Hirano M....Sugiyama Y. (2004)
Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. (PubMed id 22232210)^{1, 2} van de Steeg E....Schinkel A.H. (2012)
Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. (PubMed id 11159893)^{1, 7} Kullak-Ublick G.A....Hagenbuch B. (2001)
Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. (PubMed id 10779507)^{1, 2} Koenig J.... Keppler D. (2000)
Overexpression of OATP1B3 confers apoptotic resistance in colon cancer. (PubMed id 19074900)^{1, 9} Lee W....El-Rifai W. (2008)
Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8). (PubMed id 15226676)^{1, 9} Letschert K....Konig J. (2004)
The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma. (PubMed id 14739090)^{1, 9} Vavricka S.R....Kullak-Ublick G.A. (2004)
Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma. (PubMed id 12695556)^{1, 9} Cui Y....Keppler D. (2003)
Amino acid residues in transmembrane domain 10 of organic anion transporting polypeptide 1B3 are critical for cholecystokinin octapeptide transport. (PubMed id 18690707)^{1, 9} Gui C. and Hagenbuch B. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 28234	HGNC: 10961	AceView: SLCO1B3	Ensembl:ENSG00000111700	euGenes: HUgn28234
ECgene: SLCO1B3	Kegg: 28234	H-InvDB: SLCO1B3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLCO1B3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLCO1B3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SLCO1B3 gene:
Search GeneIP for patents involving SLCO1B3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for SLCO1B3
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLCO1B3		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLCO1B3
	OriGene Protein Over-expression Lysate for SLCO1B3		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SLCO1B3		OriGene 3'-UTR Clone for SLCO1B3
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLCO1B3		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLCO1B3
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SLCO1B3		OriGene Custom Protein Services for SLCO1B3
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLCO1B3
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLCO1B3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLCO1B3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLCO1B3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLCO1B3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLCO1B3

	GenScript Custom Purified and Recombinant Proteins Services for SLCO1B3		GenScript cDNA clones with any tag delivered in your preferred vector for SLCO1B3
	GenScript Custom Assay Services for SLCO1B3		GenScript Custom Superior Antibodies Services for SLCO1B3
	GenScript Custom overexpressing Cell Line Services for SLCO1B3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SLCO1B3 promoter
	Search Chromatin IP Primers for SLCO1B3
	RT² qPCR Primer Assay in human, mouse, rat SLCO1B3
	GNC Network for SLCO1B3
	SABiosciences PCR Arrays including human, mouse, rat SLCO1B3

Search Tocris compounds for SLCO1B3

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SLCO1B3 antibodies
	SLCO1B3 lysates

	Search for Antibodies for SLCO1B3 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for SLCO1B3
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

SLCO1B3 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SLCO1B3

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO1B3

	Browse SwitchGear 3'UTR luciferase reporter plasmids for SLCO1B3
	Browse SwitchGear Promoter luciferase reporter plasmids for SLCO1B3

ThermoFisher Antibody for SLCO1B3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLCO1B3

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SLCO1B3 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

SLCO1B3 Gene

solute carrier organic anion transporter family, member...

Aliases
for SLCO1B3 gene

Summaries
for SLCO1B3 gene

Genomic Views
for SLCO1B3 gene

Proteins
for SLCO1B3 gene

Protein Domains /
Families
for SLCO1B3 gene

Function
for SLCO1B3 gene

Pathways & Interactions
for SLCO1B3 gene

Drugs & Compounds
for SLCO1B3 gene

Transcripts
for SLCO1B3 gene

Expression
for SLCO1B3 gene

Orthologs
for SLCO1B3 gene

Paralogs
for SLCO1B3 gene

Genomic Variants
for SLCO1B3 gene

Disorders / Diseases
for SLCO1B3 gene

Publications
for SLCO1B3 gene

External Searches for SLCO1B3 gene

Genome Databases showing SLCO1B3 gene

Other Databases showing SLCO1B3 gene

Specialized Databases showing SLCO1B3 gene

Intellectual Property
for SLCO1B3 gene

Products
for SLCO1B3 gene

View Random Gene

SLCO1B3 (Gene Symbol)
Solute Carrier Organic Anion Transporter Family, Member 1B3
OATP1B3
OATP8
SLC21A8
Solute Carrier Family 21 (Organic Anion Transporter), Member 8
Liver-Specific Organic Anion Transporter 2
Organic Anion Transporter 8
Organic Anion-Transporting Polypeptide 8
LST-2
OATP-8
HBLRR
LST-3TM13
LST3
Liver-Specific Organic Anion Transporter 3TM13
Organic Anion Transporter LST-3c
Solute Carrier Organic Anion Transporter Family Member 1B3
LST2
OATP8,SLC21A8
Solute Carrier Family 21 Member 8

Advanced Search

Export list of displayed genes

SLCO1B3 Gene

solute carrier organic anion transporter family, member...

Aliasesfor SLCO1B3 gene

Summariesfor SLCO1B3 gene

Genomic Viewsfor SLCO1B3 gene

Proteinsfor SLCO1B3 gene

Protein Domains /Familiesfor SLCO1B3 gene

Functionfor SLCO1B3 gene

Pathways & Interactionsfor SLCO1B3 gene

Drugs & Compoundsfor SLCO1B3 gene

Transcriptsfor SLCO1B3 gene

Expression for SLCO1B3 gene

Orthologsfor SLCO1B3 gene

Paralogsfor SLCO1B3 gene

Genomic Variantsfor SLCO1B3 gene

Disorders / Diseasesfor SLCO1B3 gene

Publicationsfor SLCO1B3 gene

External Searches for SLCO1B3 gene

Genome Databases showing SLCO1B3 gene

Other Databases showing SLCO1B3 gene

Specialized Databases showing SLCO1B3 gene

Intellectual Propertyfor SLCO1B3 gene

Productsfor SLCO1B3 gene

View Random Gene

Aliases
for SLCO1B3 gene

Summaries
for SLCO1B3 gene

Genomic Views
for SLCO1B3 gene

Proteins
for SLCO1B3 gene

Protein Domains /
Families
for SLCO1B3 gene

Function
for SLCO1B3 gene

Pathways & Interactions
for SLCO1B3 gene

Drugs & Compounds
for SLCO1B3 gene

Transcripts
for SLCO1B3 gene

Expression
for SLCO1B3 gene

Orthologs
for SLCO1B3 gene

Paralogs
for SLCO1B3 gene

Genomic Variants
for SLCO1B3 gene

Disorders / Diseases
for SLCO1B3 gene

Publications
for SLCO1B3 gene

Intellectual Property
for SLCO1B3 gene

Products
for SLCO1B3 gene