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Aliases for SLCO1B1 Gene

Aliases for SLCO1B1 Gene

  • Solute Carrier Organic Anion Transporter Family, Member 1B1 2 3
  • OATP1B1 3 4 6
  • OATP2 3 4 6
  • OATPC 3 4 6
  • LST1 3 4 6
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 6 2 3
  • Sodium-Independent Organic Anion-Transporting Polypeptide 2 3 4
  • Liver-Specific Organic Anion Transporter 1 3 4
  • Solute Carrier Family 21 Member 6 3 4
  • SLC21A6 3 4
  • OATP-2 3 4
  • OATP-C 3 4
  • HBLRR 3 6
  • LST-1 3 4
  • Solute Carrier Organic Anion Transporter Family Member 1B1 3

External Ids for SLCO1B1 Gene

Previous HGNC Symbols for SLCO1B1 Gene

  • SLC21A6

Previous GeneCards Identifiers for SLCO1B1 Gene

  • GC12P021175
  • GC12P021284

Summaries for SLCO1B1 Gene

Entrez Gene Summary for SLCO1B1 Gene

  • This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]

GeneCards Summary for SLCO1B1 Gene

SLCO1B1 (Solute Carrier Organic Anion Transporter Family, Member 1B1) is a Protein Coding gene. Diseases associated with SLCO1B1 include statin toxicity and hyperbilirubinemia, rotor type, digenic. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include sodium-independent organic anion transmembrane transporter activity. An important paralog of this gene is SLCO1B7.

UniProtKB/Swiss-Prot for SLCO1B1 Gene

  • Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.

Gene Wiki entry for SLCO1B1 Gene

PharmGKB "VIP" Summary for SLCO1B1 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO1B1 Gene

Genomics for SLCO1B1 Gene

Regulatory Elements for SLCO1B1 Gene

Genomic Location for SLCO1B1 Gene

Start:
21,131,194 bp from pter
End:
21,239,796 bp from pter
Size:
108,603 bases
Orientation:
Plus strand

Genomic View for SLCO1B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLCO1B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO1B1 Gene

Proteins for SLCO1B1 Gene

  • Protein details for SLCO1B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6L6-SO1B1_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 1B1
    Protein Accession:
    Q9Y6L6
    Secondary Accessions:
    • B2R7G2
    • Q29R64
    • Q9NQ37
    • Q9UBF3
    • Q9UH89

    Protein attributes for SLCO1B1 Gene

    Size:
    691 amino acids
    Molecular mass:
    76449 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLCO1B1 Gene

Proteomics data for SLCO1B1 Gene at MOPED

Post-translational modifications for SLCO1B1 Gene

  • Glycosylation at Asn130, Asn134, Asn432, Asn503, Asn516, and Asn617
  • Modification sites at PhosphoSitePlus

Other Protein References for SLCO1B1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLCO1B1 Gene

Domains for SLCO1B1 Gene

Gene Families for SLCO1B1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6L6

UniProtKB/Swiss-Prot:

SO1B1_HUMAN :
  • Q9Y6L6
Domain:
  • Contains 1 Kazal-like domain.
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO1B1: view

Function for SLCO1B1 Gene

Molecular function for SLCO1B1 Gene

UniProtKB/Swiss-Prot Function: Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.

Gene Ontology (GO) - Molecular Function for SLCO1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005515 protein binding --
GO:0015347 sodium-independent organic anion transmembrane transporter activity TAS 10358072
genes like me logo Genes that share ontologies with SLCO1B1: view

miRNA for SLCO1B1 Gene

miRTarBase miRNAs that target SLCO1B1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLCO1B1 Gene

Localization for SLCO1B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO1B1 Gene

Basolateral cell membrane; Multi-pass membrane protein. Note=Detected in basolateral membranes of hepatocytes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLCO1B1 Gene COMPARTMENTS Subcellular localization image for SLCO1B1 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLCO1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10358072
GO:0016020 membrane TAS 10358072
GO:0016021 integral component of membrane --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with SLCO1B1: view

Pathways for SLCO1B1 Gene

genes like me logo Genes that share pathways with SLCO1B1: view

Interacting Proteins for SLCO1B1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000256958%0d%0a9606.ENSP00000285238%0d%0a9606.ENSP00000377549%0d%0a9606.ENSP00000295897%0d%0a
Selected Interacting proteins: ENSP00000256958 for SLCO1B1 Gene via STRING

Gene Ontology (GO) - Biological Process for SLCO1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0008206 bile acid metabolic process TAS --
GO:0015711 organic anion transport TAS 10358072
GO:0015721 bile acid and bile salt transport TAS --
GO:0043252 sodium-independent organic anion transport TAS --
genes like me logo Genes that share ontologies with SLCO1B1: view

Compounds for SLCO1B1 Gene

(93) HMDB Compounds for SLCO1B1 Gene

Compound Synonyms Cas Number PubMed IDs
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
58814-71-4
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-oate
63266-91-1
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-oate
63266-89-7
12a-Hydroxy-3-oxocholadienic acid
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oate
13535-96-1
12b-Hydroxy-5b-cholanoic acid
  • 12b-Hydroxy-5b-cholanic acid
15173-23-6

(59) Drugbank Compounds for SLCO1B1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Acetylcysteine
616-91-1 transporter inhibitor
Aminohippurate
  • Aminohippurate Sodium
94-16-6 transporter inhibitor
Atorvastatin
134523-00-5 transporter substrate inhibitor
Axitinib
319460-85-0 transporter substrate
Bezafibrate
  • Bezafibrat
41859-67-0 transporter inhibitor

(10) IUPHAR Ligand for SLCO1B1 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]estrone-3-sulphate None None
gemfibrozil Inhibitor Inhibition
rifampicin Inhibitor Inhibition
cyclosporin A Inhibitor Inhibition
sildenafil Inhibitor Inhibition
rifamycin SV Inhibitor Inhibition
indocyanine Green Inhibitor Inhibition
[3H]estradiol-17beta-glucuronide None None
pravastatin None None
glycyrrhizin Inhibitor Inhibition

(28) Novoseek inferred chemical compound relationships for SLCO1B1 Gene

Compound -log(P) Hits PubMed IDs
oatp 91.9 16
estradiol-17beta-glucuronide 84.2 1
taurocholate 81.9 8
pravastatin 79.4 40
estrone sulfate 78.6 5
genes like me logo Genes that share compounds with SLCO1B1: view

Transcripts for SLCO1B1 Gene

mRNA/cDNA for SLCO1B1 Gene

(40) Selected AceView cDNA sequences:
(11) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLCO1B1 Gene

Solute carrier organic anion transporter family, member 1B1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO1B1 Gene

No ASD Table

Relevant External Links for SLCO1B1 Gene

GeneLoc Exon Structure for
SLCO1B1
ECgene alternative splicing isoforms for
SLCO1B1

Expression for SLCO1B1 Gene

mRNA expression in normal human tissues for SLCO1B1 Gene

mRNA differential expression in normal tissues according to GTEx for SLCO1B1 Gene

This gene is overexpressed in Liver (52.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLCO1B1 Gene

SOURCE GeneReport for Unigene cluster for SLCO1B1 Gene Hs.449738

mRNA Expression by UniProt/SwissProt for SLCO1B1 Gene

Q9Y6L6-SO1B1_HUMAN
Tissue specificity: Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.
genes like me logo Genes that share expressions with SLCO1B1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLCO1B1 Gene

Orthologs for SLCO1B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLCO1B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLCO1B1 35
  • 99.13 (n)
  • 98.26 (a)
SLCO1B1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 70 (a)
OneToMany
dog
(Canis familiaris)
Mammalia OATPC 36
  • 69 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Slco1b2 36
  • 64 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 39 (a)
OneToMany
SLCO1B1 35
  • 60.35 (n)
  • 50.73 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slco1b3 35
  • 55.49 (n)
  • 48.78 (a)
Species with no ortholog for SLCO1B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLCO1B1 Gene

ENSEMBL:
Gene Tree for SLCO1B1 (if available)
TreeFam:
Gene Tree for SLCO1B1 (if available)

Paralogs for SLCO1B1 Gene

genes like me logo Genes that share paralogs with SLCO1B1: view

Variants for SLCO1B1 Gene

Sequence variations from dbSNP and Humsavar for SLCO1B1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs717958 -- 21,229,796(+) ACAAT(G/T)ATGTC intron-variant
rs717959 -- 21,229,966(+) tgagt(C/T)tctca intron-variant
rs964614 -- 21,176,456(+) TTACA(C/T)ACAAT intron-variant
rs964615 -- 21,176,490(+) GAAAC(C/T)AGGAT intron-variant
rs976754 -- 21,162,588(-) TGTGG(C/T)ACACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO1B1 Gene

Variant ID Type Subtype PubMed ID
nsv898872 CNV Loss 21882294
nsv515735 CNV Gain+Loss 19592680
nsv469159 CNV Loss 19166990
nsv898880 CNV Loss 21882294
dgv1389n71 CNV Loss 21882294
nsv898883 CNV Loss 21882294
nsv898884 CNV Loss 21882294
dgv1390n71 CNV Loss 21882294
nsv898886 CNV Loss 21882294

Relevant External Links for SLCO1B1 Gene

HapMap Linkage Disequilibrium report
SLCO1B1
Human Gene Mutation Database (HGMD)
SLCO1B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO1B1 Gene

Disorders for SLCO1B1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for SLCO1B1 Gene including...

Search for SLCO1B1 Gene in MalaCards »

(1) OMIM Diseases for SLCO1B1 Gene (604843)

UniProtKB/Swiss-Prot

SO1B1_HUMAN
  • Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. {ECO:0000269 PubMed:22232210}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for SLCO1B1 Gene

(10) Novoseek inferred disease relationships for SLCO1B1 Gene

Disease -log(P) Hits PubMed IDs
hyperbilirubinemia 70.5 13
jaundice neonatal 65.3 2
cholestasis 54.9 1
g6pd deficiency 48 4
myopathy 34.1 2

Relevant External Links for SLCO1B1

Genetic Association Database (GAD)
SLCO1B1
Human Genome Epidemiology (HuGE) Navigator
SLCO1B1
genes like me logo Genes that share disorders with SLCO1B1: view

Publications for SLCO1B1 Gene

  1. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. (PMID: 10358072) Abe T. … Yawo H. (J. Biol. Chem. 1999) 2 3 4 23 25
  2. Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans. (PMID: 11477075) Tirona R.G. … Kim R.B. (J. Biol. Chem. 2001) 3 4 23 48
  3. A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl- CoA reductase inhibitor transporters. (PMID: 10601278) Hsiang B.H. … Kirchgessner T.G. (J. Biol. Chem. 1999) 3 4 23 25
  4. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. (PMID: 10644574) Koenig J. … Keppler D. (Am. J. Physiol. 2000) 3 4 23 25
  5. A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter. (PMID: 12196548) Michalski C. … Koenig J. (J. Biol. Chem. 2002) 3 4 23 26

Products for SLCO1B1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Transporters in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SLCO1B1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SLCO1B1
    • Block miRNA regulation of SLCO1B1 using miScript Target Protectors

    Sources for SLCO1B1 Gene

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