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Aliases for SLCO1B1 Gene

Aliases for SLCO1B1 Gene

  • Solute Carrier Organic Anion Transporter Family Member 1B1 2 3 5
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 6 2 3
  • Solute Carrier Organic Anion Transporter Family, Member 1B1 2 3
  • Sodium-Independent Organic Anion-Transporting Polypeptide 2 3 4
  • Liver-Specific Organic Anion Transporter 1 3 4
  • SLC21A6 3 4
  • OATP1B1 3 4
  • OATP-2 3 4
  • OATP-C 3 4
  • LST-1 3 4
  • OATP2 3 4
  • OATPC 3 4
  • LST1 3 4
  • Solute Carrier Family 21 Member 6 4
  • HBLRR 3

External Ids for SLCO1B1 Gene

Previous HGNC Symbols for SLCO1B1 Gene

  • SLC21A6

Previous GeneCards Identifiers for SLCO1B1 Gene

  • GC12P021175
  • GC12P021284

Summaries for SLCO1B1 Gene

Entrez Gene Summary for SLCO1B1 Gene

  • This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]

GeneCards Summary for SLCO1B1 Gene

SLCO1B1 (Solute Carrier Organic Anion Transporter Family Member 1B1) is a Protein Coding gene. Diseases associated with SLCO1B1 include hyperbilirubinemia, rotor type, digenic and slco1b1-related altered drug metabolism. Among its related pathways are Bile secretion and Statin Pathway - Generalized, Pharmacokinetics. GO annotations related to this gene include transporter activity and sodium-independent organic anion transmembrane transporter activity. An important paralog of this gene is SLCO1B7.

UniProtKB/Swiss-Prot for SLCO1B1 Gene

  • Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.

Tocris Summary for SLCO1B1 Gene

  • ATP-binding cassette (ABC) transporters form one of the largest groups of paralogous protein families that have a wide diversity of functions and substrates. Specificity has been shown for small and large molecules, highly charged molecules and highly hydrophobic systems.

Gene Wiki entry for SLCO1B1 Gene

PharmGKB "VIP" Summary for SLCO1B1 Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for SLCO1B1 Gene

Genomics for SLCO1B1 Gene

Regulatory Elements for SLCO1B1 Gene

Enhancers for SLCO1B1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLCO1B1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLCO1B1 Gene

Chromosome:
12
Start:
21,131,194 bp from pter
End:
21,239,796 bp from pter
Size:
108,603 bases
Orientation:
Plus strand

Genomic View for SLCO1B1 Gene

Genes around SLCO1B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO1B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO1B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO1B1 Gene

Proteins for SLCO1B1 Gene

  • Protein details for SLCO1B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6L6-SO1B1_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 1B1
    Protein Accession:
    Q9Y6L6
    Secondary Accessions:
    • B2R7G2
    • Q29R64
    • Q9NQ37
    • Q9UBF3
    • Q9UH89

    Protein attributes for SLCO1B1 Gene

    Size:
    691 amino acids
    Molecular mass:
    76449 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLCO1B1 Gene

Proteomics data for SLCO1B1 Gene at MOPED

Post-translational modifications for SLCO1B1 Gene

  • Glycosylation at Asn 130, Asn 134, Asn 432, Asn 503, Asn 516, and Asn 617
  • Modification sites at PhosphoSitePlus

Other Protein References for SLCO1B1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLCO1B1 Gene

Domains & Families for SLCO1B1 Gene

Gene Families for SLCO1B1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6L6

UniProtKB/Swiss-Prot:

SO1B1_HUMAN :
  • Contains 1 Kazal-like domain.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
Domain:
  • Contains 1 Kazal-like domain.
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO1B1: view

Function for SLCO1B1 Gene

Molecular function for SLCO1B1 Gene

UniProtKB/Swiss-Prot Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.

Gene Ontology (GO) - Molecular Function for SLCO1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015125 bile acid transmembrane transporter activity IBA,TAS --
GO:0015349 thyroid hormone transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLCO1B1: view
genes like me logo Genes that share phenotypes with SLCO1B1: view

Human Phenotype Ontology for SLCO1B1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for SLCO1B1 Gene

miRTarBase miRNAs that target SLCO1B1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLCO1B1 Gene

Localization for SLCO1B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO1B1 Gene

Basolateral cell membrane; Multi-pass membrane protein. Note=Detected in basolateral membranes of hepatocytes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLCO1B1 Gene COMPARTMENTS Subcellular localization image for SLCO1B1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLCO1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,TAS 10358072
genes like me logo Genes that share ontologies with SLCO1B1: view

Pathways & Interactions for SLCO1B1 Gene

genes like me logo Genes that share pathways with SLCO1B1: view

Interacting Proteins for SLCO1B1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000256958%0d%0a9606.ENSP00000285238%0d%0a9606.ENSP00000377549%0d%0a9606.ENSP00000295897%0d%0a
Selected Interacting proteins: ENSP00000256958 for SLCO1B1 Gene via STRING

Gene Ontology (GO) - Biological Process for SLCO1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008206 bile acid metabolic process IBA,TAS --
GO:0043252 sodium-independent organic anion transport TAS --
genes like me logo Genes that share ontologies with SLCO1B1: view

No data available for SIGNOR curated interactions for SLCO1B1 Gene

Drugs & Compounds for SLCO1B1 Gene

(120) Drugs for SLCO1B1 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pravastatin Approved Pharma Competitive, Inhibitor, inhibitor, Transporter, substrate 145
Rifampicin Approved Pharma Agonist, binder, Target, Transporter, inhibitor Pregnane X receptor agonist; antibiotic 324
Irinotecan Approved, Investigational Pharma Transporter, inhibitor Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1055
Gemfibrozil Approved Pharma Agonist, activator, Transporter, inhibitor 23
Methotrexate Approved Pharma Transporter, substrate Folate antagonist,inhibits DFHR, Cytotoxic agent 1466

(96) Additional Compounds for SLCO1B1 Gene - From: HMDB, Tocris, Novoseek, and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
estrone sulfate
  • Conestoral
  • Estrogenic substances
  • Estrone
  • Estrone hydrogen sulfate
  • Estrone hydrogen sulphate
481-97-0
[<sup>3</sup>H]estradiol-17beta-glucuronide
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
  • Chenodeoxycholic acid-3-b-D-glucuronide
  • Chenodeoxycholic acid-3-beta-delta-glucuronide
58814-71-4
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxy-5b-Cholanoate
  • 1,3,12-Trihydroxy-5b-Cholanoic acid
  • 1,3,12-Trihydroxy-Cholan-24-oate
  • 1,3,12-Trihydroxy-Cholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-oate
63266-91-1
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oate
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-oate
  • 1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholanoate
63266-89-7

(5) Tocris Compounds for SLCO1B1 Gene

Compound Action Cas Number
Estropipate Estrogen receptor agonist and OATP1B1 inhibitor 7280-37-7
Fumitremorgin C Inhibitor of BCRP-mediated multidrug resistance 118974-02-0
Ko 143 Potent and selective BCRP inhibitor 461054-93-3
MK 571 Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor 115104-28-4
Reversan Selective MRP1 and P-gp inhibitor 313397-13-6

(1) ApexBio Compounds for SLCO1B1 Gene

Compound Action Cas Number
Probenecid 57-66-9
genes like me logo Genes that share compounds with SLCO1B1: view

Transcripts for SLCO1B1 Gene

mRNA/cDNA for SLCO1B1 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLCO1B1 Gene

Solute carrier organic anion transporter family, member 1B1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO1B1 Gene

No ASD Table

Relevant External Links for SLCO1B1 Gene

GeneLoc Exon Structure for
SLCO1B1
ECgene alternative splicing isoforms for
SLCO1B1

Expression for SLCO1B1 Gene

mRNA expression in normal human tissues for SLCO1B1 Gene

mRNA differential expression in normal tissues according to GTEx for SLCO1B1 Gene

This gene is overexpressed in Liver (x52.5).

Protein differential expression in normal tissues from HIPED for SLCO1B1 Gene

This gene is overexpressed in Liver (39.0), Gallbladder (18.1), and Fetal Liver (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLCO1B1 Gene



SOURCE GeneReport for Unigene cluster for SLCO1B1 Gene Hs.449738

mRNA Expression by UniProt/SwissProt for SLCO1B1 Gene

Q9Y6L6-SO1B1_HUMAN
Tissue specificity: Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.
genes like me logo Genes that share expression patterns with SLCO1B1: view

Protein tissue co-expression partners for SLCO1B1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLCO1B1 Gene

Orthologs for SLCO1B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLCO1B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLCO1B1 35
  • 99.13 (n)
  • 98.26 (a)
SLCO1B1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 70 (a)
OneToMany
dog
(Canis familiaris)
Mammalia OATPC 36
  • 69 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Slco1b2 36
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToMany
chicken
(Gallus gallus)
Aves SLCO1B1 35
  • 60.35 (n)
  • 50.73 (a)
-- 36
  • 39 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slco1b3 35
  • 55.49 (n)
  • 48.78 (a)
Species with no ortholog for SLCO1B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLCO1B1 Gene

ENSEMBL:
Gene Tree for SLCO1B1 (if available)
TreeFam:
Gene Tree for SLCO1B1 (if available)

Paralogs for SLCO1B1 Gene

genes like me logo Genes that share paralogs with SLCO1B1: view

Variants for SLCO1B1 Gene

Sequence variations from dbSNP and Humsavar for SLCO1B1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs56101265 - 21,172,782(+) GAAGC(C/T)TTGAA reference, missense
rs56061388 - 21,174,595(+) GATTG(C/T)ATTTG reference, missense
rs2306283 - 21,176,804(-) TGAAT(C/T)GATAT reference, missense
VAR_015073 -
rs11045819 - 21,176,879(+) CATCA(A/C)CTGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLCO1B1 Gene

Variant ID Type Subtype PubMed ID
nsv898872 CNV Loss 21882294
nsv515735 CNV Gain+Loss 19592680
nsv469159 CNV Loss 19166990
nsv898880 CNV Loss 21882294
dgv1389n71 CNV Loss 21882294
nsv898883 CNV Loss 21882294
nsv898884 CNV Loss 21882294
dgv1390n71 CNV Loss 21882294
nsv898886 CNV Loss 21882294

Variation tolerance for SLCO1B1 Gene

Residual Variation Intolerance Score: 80.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.28; 70.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLCO1B1 Gene

HapMap Linkage Disequilibrium report
SLCO1B1
Human Gene Mutation Database (HGMD)
SLCO1B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO1B1 Gene

Disorders for SLCO1B1 Gene

MalaCards: The human disease database

(14) MalaCards diseases for SLCO1B1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hyperbilirubinemia, rotor type, digenic
  • rotor syndrome
slco1b1-related altered drug metabolism
  • drug sensitivity
statin toxicity
neonatal jaundice
  • neonatal hyperbilirubinemia
glucosephosphate dehydrogenase deficiency
  • deficiency of g-6pd
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

SO1B1_HUMAN
  • Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. {ECO:0000269 PubMed:22232210}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLCO1B1

Genetic Association Database (GAD)
SLCO1B1
Human Genome Epidemiology (HuGE) Navigator
SLCO1B1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLCO1B1
genes like me logo Genes that share disorders with SLCO1B1: view

No data available for Genatlas for SLCO1B1 Gene

Publications for SLCO1B1 Gene

  1. Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans. (PMID: 11477075) Tirona R.G. … Kim R.B. (J. Biol. Chem. 2001) 3 4 23 48 67
  2. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. (PMID: 10358072) Abe T. … Yawo H. (J. Biol. Chem. 1999) 2 3 23 25 26
  3. Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. (PMID: 12490595) Tirona R.G. … Kim R.B. (J. Pharmacol. Exp. Ther. 2003) 3 23 25 26
  4. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. (PMID: 10644574) Koenig J. … Keppler D. (Am. J. Physiol. 2000) 3 23 25 26
  5. A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl- CoA reductase inhibitor transporters. (PMID: 10601278) Hsiang B.H. … Kirchgessner T.G. (J. Biol. Chem. 1999) 3 23 25 26

Products for SLCO1B1 Gene

Sources for SLCO1B1 Gene

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