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SLCO1B1 Gene

protein-coding   GIFtS: 65
GCID: GC12P021284

Solute Carrier Organic Anion Transporter Family, Member...

(Previous names: solute carrier family 21 (organic anion transporter), member...)
(Previous symbol: SLC21A6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Organic Anion Transporter Family, Member 1B11 2     Sodium-Independent Organic Anion-Transporting Polypeptide 22 3
SLC21A61 2 3     Solute Carrier Family 21 Member 62 3
LST12 3 5     LST-12 3
OATP1B12 3 5     OATP-22 3
OATP22 3 5     OATP-C2 3
OATPC2 3 5     HBLRR2 5
Solute Carrier Family 21 (Organic Anion Transporter), Member 61 2     Solute Carrier Organic Anion Transporter Family Member 1B12
Liver-Specific Organic Anion Transporter 12 3     

External Ids:    HGNC: 109591   Entrez Gene: 105992   Ensembl: ENSG000001345387   OMIM: 6048435   UniProtKB: Q9Y6L63   
ORGUL members:         

Export aliases for SLCO1B1 gene to outside databases

Previous GC identifers: GC12P021175 GC12P021058


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLCO1B1 Gene:
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a
transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including
bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of
drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes.
Polymorphisms in the gene encoding this protein are associated with impaired transporter function. (provided by
RefSeq, Mar 2009)

GeneCards Summary for SLCO1B1 Gene:
SLCO1B1 (solute carrier organic anion transporter family, member 1B1) is a protein-coding gene. Diseases associated with SLCO1B1 include hyperbilirubinemia, rotor type, digenic, and rotor syndrome. GO annotations related to this gene include sodium-independent organic anion transmembrane transporter activity. An important paralog of this gene is SLCO2A1.

UniProtKB/Swiss-Prot: SO1B1_HUMAN, Q9Y6L6
Function: Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate,
dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane
B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and
organic anions from the liver

Gene Wiki entry for SLCO1B1 Gene

PharmGKB "VIP" summary for SLCO1B1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLCO1B1 gene promoter:
         HOXA9B   HOXA9   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   C/EBPalpha   CREB   deltaCREB   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLCO1B1 promoter sequence
   Search Chromatin IP Primers for SLCO1B1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLCO1B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p   Ensembl cytogenetic band:  12p12.2   HGNC cytogenetic band: 12p12

SLCO1B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO1B1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P021284:  view genomic region     (about GC identifiers)

Start:
21,284,128 bp from pter      End:
21,392,730 bp from pter
Size:
108,603 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SO1B1_HUMAN, Q9Y6L6 (See protein sequence)
Recommended Name: Solute carrier organic anion transporter family member 1B1  
Size: 691 amino acids; 76449 Da
Secondary accessions: B2R7G2 Q29R64 Q9NQ37 Q9UBF3 Q9UH89

Explore the universe of human proteins at neXtProt for SLCO1B1: NX_Q9Y6L6

Explore proteomics data for SLCO1B1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn130, Asn134, Asn432, Asn503, Asn516, Asn617
  • Modification sites at PhosphoSitePlus

  • See SLCO1B1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006437.3  
    ENSEMBL proteins: 
     ENSP00000256958  
    Reactome Protein details: Q9Y6L6

    SLCO1B1 Human Recombinant Protein Products:

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    SLCO1B1 Antibody Products:

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    SLCO1B1 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: OATP1B1
    SLCO family of organic anion transporting polypeptides

    4 InterPro protein domains:
     IPR002350 Kazal_dom
     IPR004156 OA_transporter
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9Y6L6

    ProtoNet protein and cluster: Q9Y6L6

    2 Blocks protein domains:
    IPB004156 Organic anion transporter polypeptide (OATP)
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: SO1B1_HUMAN, Q9Y6L6
    Similarity: Belongs to the organo anion transporter (TC 2.A.60) family
    Similarity: Contains 1 Kazal-like domain


    SLCO1B1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SO1B1_HUMAN, Q9Y6L6
    Function: Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate,
    dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane
    B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and
    organic anions from the liver

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005515protein binding ----
    GO:0015347sodium-independent organic anion transmembrane transporter activity TAS10358072
         
    SLCO1B1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLCO1B1
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    miRNA
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    miRTarBase miRNAs that target SLCO1B1:
    hsa-mir-335-5p (MIRT018741), hsa-mir-26b-5p (MIRT030029)

    Block miRNA regulation of human, mouse, rat SLCO1B1 using miScript Target Protectors
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    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO1B1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SO1B1_HUMAN, Q9Y6L6: Basolateral cell membrane; Multi-pass membrane protein. Note=Detected in basolateral
    membranes of hepatocytes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus2
    extracellular1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS10358072
    GO:0016020membrane TAS10358072
    GO:0016021integral component of membrane ----
    GO:0016323basolateral plasma membrane IEA--

    SLCO1B1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLCO1B1 About   (see all 12)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Codeine and Morphine Pathway, Pharmacokinetics
    Codeine and Morphine Pathway, Pharmacokinetics0.33
    Codeine and morphine metabolism0.00
    2Statin Pathway - Generalized, Pharmacokinetics
    Statin Pathway - Generalized, Pharmacokinetics0.50
    Fluvastatin Pathway, Pharmacokinetics0.00
    Ibuprofen Pathway, Pharmacokinetics0.50
    Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics0.00
    Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics0.00
    Pravastatin Pathway, Pharmacokinetics0.00
    Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics0.00
    Rosuvastatin Pathway, Pharmacokinetics0.00
    3Synthesis of bile acids and bile salts
    Bile acid and bile salt metabolism0.73
    Recycling of bile acids and salts0.00
    4Irinotecan Pathway, Pharmacokinetics
    Irinotecan Pathway, Pharmacokinetics0.69
    Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics0.50
    5Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transmembrane transport of small molecules0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SLCO1B1
        Hepatic ABC Transporters

    2 BioSystems Pathways for SLCO1B1
        Codeine and morphine metabolism
    Drug Induction of Bile Acid Pathway

    2 Reactome Pathways for SLCO1B1
        Recycling of bile acids and salts
    Transport of organic anions

    Selected PharmGKB Pathways for SLCO1B1 (see all 13)
        Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics
    Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics
    Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
    Codeine and Morphine Pathway, Pharmacokinetics
    Fluvastatin Pathway, Pharmacokinetics

    1 Kegg Pathway  (Kegg details for SLCO1B1):
        Bile secretion


    SLCO1B1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SLCO1B1: 
              Drug Transporters in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLCO1B1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLCO1B1 (ENSP000002569584) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCB11ENSP000002638174STRING: ENSP00000263817
    ABCC3ENSP000002852384STRING: ENSP00000285238
    ALBENSP000002958974STRING: ENSP00000295897
    FABP6ENSP000003775494STRING: ENSP00000377549
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0008206bile acid metabolic process TAS--
    GO:0015711organic anion transport TAS10358072
    GO:0015721bile acid and bile salt transport TAS--
    GO:0043252sodium-independent organic anion transport TAS--

    SLCO1B1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for SLCO1B1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PSC 833Inhibitor of P-gp-mediated MDR[121584-18-7]
    XR 9051 HClPotent modulator of P-gp-mediated MDR[180422-22-4]
    Ko 143Potent and selective BCRP inhibitor[461054-93-3]
    ProbenecidMRP inhibitor[57-66-9]
    Elacridar hydrochlorideP-gp inhibitor[143851-98-3]

    Selected HMDB Compounds for SLCO1B1 (see all 93)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acidChenodeoxycholic acid 3-glucuronide (see all 3)58814-71-412196548
    1,3,12-Trihydroxycholan-24-oic acid1,3,12-Trihydroxycholan-24-oate (see all 6)63266-91-112196548
    1,3,7,12-Tetrahydroxycholan-24-oic acid1,3,7,12-Tetrahydroxycholan-24-oate (see all 10)63266-89-712196548
    12-Ketodeoxycholic acid12-Dehydrodeoxycholate (see all 20)5130-29-012196548
    12a-Hydroxy-3-oxocholadienic acid12a-Hydroxy-3-oxo-4,6-choladien-24-oate (see all 8)13535-96-112196548
    12b-Hydroxy-5b-cholanoic acid12b-Hydroxy-5b-cholanic acid (see all 9)15173-23-612196548
    1b,3a,12a-Trihydroxy-5b-cholanoic acid1,3,12-trihydroxy-(5b)-Cholan-24-oate (see all 6)80434-32-812196548
    1b,3a,7a-Trihydroxy-5b-cholanoic acid1 beta,3a,7a-Trihydroxy-5b-cholanoate (see all 18)99598-04-612196548
    1b-Hydroxycholic acid1b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 5)80875-94-112196548
    2b,3a,7a,12a-Tetrahydroxy-5b-cholanoic acid2b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 7)60696-60-812196548

    Selected DrugBank Compounds for SLCO1B1 (see all 59)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Conjugated EstrogensEstrogens (see all 10)438-67-5transportersubstrate inhibitor12101011 11683238 11159893 15159445 14977862 12906759 15901800 11134001
    Digoxin-- 20830-75-5transportersubstrate inhibitor12101011 11408557 11451172 11883641 11257421 11818398
    Taurocholic Acid-- 81-24-3transportersubstrate inhibitor inducer10358072 11159893 10601278 12235261 12906759 11134001
    Pravastatin-- 81093-37-0transportersubstrate inhibitor10601278 19919292 15616150 15970799 15901800
    CyclosporineCiclosporin (see all 4)59865-13-3transporterinhibitor12538813 14530907 12490595 12906759
    RifampinRFP (see all 3)13292-46-1transporterinhibitor12085361 19919292 12490595 11134001
    Cholic Acid-- 81-25-4transportersubstrate inhibitor inducer10644574 12235261 11134001
    DinoprostoneDinoprostone Prostaglandin E2 (see all 3)363-24-6transportersubstrate10358072 11159893 10873595
    Atorvastatin-- 134523-00-5transportersubstrate inhibitor10601278 15970799
    CerivastatinCerivastatin sodium (see all 2)145599-86-6transportersubstrate15970799 15901800

    10 IUPHAR Ligands for SLCO1B1 (OATP1B1)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]estrone-3-sulphate
    NoneNone--
    gemfibrozil
    InhibitorInhibition--
    rifampicin
    InhibitorInhibition--
    cyclosporin A
    InhibitorInhibition--
    sildenafil
    InhibitorInhibition--
    rifamycin SV
    InhibitorInhibition--
    indocyanine Green
    InhibitorInhibition--
    [3H]estradiol-17beta-glucuronide
    NoneNone--
    pravastatin
    NoneNone--
    glycyrrhizin
    InhibitorInhibition--

    Selected Novoseek inferred chemical compound relationships for SLCO1B1 gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oatp 91.9 31 12542534 (2), 19661216 (2), 19785645 (2), 10644574 (2) (see all 12)
    estradiol-17beta-glucuronide 84.2 1 15564882 (1)
    taurocholate 81.9 8 12196548 (1), 16637898 (1), 11408557 (1), 17989996 (1) (see all 8)
    pravastatin 79.4 53 17177112 (7), 16678544 (5), 15864131 (5), 11356905 (4) (see all 15)
    estrone sulfate 78.6 7 17918775 (2), 17641954 (1), 15159445 (1), 11477075 (1)
    androstane 73.8 2 15382119 (1), 18334180 (1)
    repaglinide 66.8 15 15961978 (3), 16198658 (2), 16796707 (1), 19785645 (1)
    rosuvastatin 65.7 5 15289793 (2), 15116058 (2), 18617601 (1)
    uridine diphosphate 59.6 2 19238116 (1)
    bromosulfophthalein 58.5 2 17989996 (1), 10644574 (1)

    Selected PharmGKB related drug/compound annotations for SLCO1B1 gene (see all 12)    About this table
    Drug/compound PharmGKB Annotation
    SN-38CA  
    atorvastatinCA  
    cerivastatinCA  
    fluvastatinCA  
    hmg coa reductase inhibitorsCA  
    methotrexateCA  
    nateglinideCA  
    pravastatinCA  
    repaglinideCA  
    rifampinCA  



    SLCO1B1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for SLCO1B1 gene: 
    NM_006446.4  

    Unigene Cluster for SLCO1B1:

    Solute carrier organic anion transporter family, member 1B1
    Hs.449738  [show with all ESTs]
    Unigene Representative Sequence: AF205071
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000256958(uc001req.4)
    miRNA
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    Block miRNA regulation of human, mouse, rat SLCO1B1 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidSLCO1B1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat SLCO1B1

    Additional mRNA sequence: 

    AB026257.1 AF060500.1 AF205071.1 AJ132573.1 AK312970.1 BC005243.2 BC020696.1 BC054878.1 
    BC070172.1 BC105596.1 BC114376.1 

    2 DOTS entries:

    DT.430127  DT.92431204 

    Selected AceView cDNA sequences (see all 40):

    CB161473 CB161434 BX283296 BG562880 CB161880 AA382692 BG618727 CB163667 
    AB026257 BG567055 AF060500 BG566359 BM764855 BC054878 H62927 AF205071 
    BX283459 BC070172 NM_006446 BG569568 BC020696 CB147672 AF401642 BG569386 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLCO1B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTACTGTGT
    SLCO1B1 Expression
    About this image

    SLCO1B1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLCO1B1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.449738

    UniProtKB/Swiss-Prot: SO1B1_HUMAN, Q9Y6L6
    Tissue specificity: Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Not
    detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis,
    ovary, small intestine, colon and leukocyte

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLCO1B1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SLCO1B11 solute carrier organic anion transporter family, member more 60.35(n)
    50.73(a)
      418187  XM_416418.4  XP_416418.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    36(a)
    1 → many
    5(8325221-8353497)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slco1b31 solute carrier organic anion transporter family, member more 55.49(n)
    48.78(a)
      613085  NM_001032322.1  NP_001027493.1 
            Species with no ortholog for SLCO1B1

    ENSEMBL Gene Tree for SLCO1B1 (if available)
    TreeFam Gene Tree for SLCO1B1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLCO1B1 gene
    SLCO2A12  SLCO4C12  SLCO1B72  ENSG000002570622  SLCO1B32  SLCO3A12  SLCO2B12  SLCO5A12  
    SLCO6A12  SLCO1A22  SLCO1C12  ENSG000002570462  SLCO4A12  
    12 SIMAP similar genes for SLCO1B1 using alignment to 8 protein entries:     SO1B1_HUMAN (see all proteins):
    SLCO1B3    SLC21A8    LST3    SLCO1B7    SLCO1A2    SLCO1C1
    SLCO3A1    SLCO2B1    SLCO2A1    SLCO5A1    SLCO4C1    SLCO4A1

    SLCO1B1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLCO1B1 (see all 2764)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1396912451,2
    Cuntested121199918(+) TCCAAT/ACATTG 2 /N /I mis11Minor allele frequency- A:0.00NA 4506
    rs356943781,2
    C,F--21058517(+) AACAT-/AAAAAA 1 -- int12Minor allele frequency- A:0.50NA CSA 4
    rs1999035431,2
    --21058521(+) TAAAA-/GAACAG 1 -- int10--------
    rs41490891,2
    C--21058523(+) AAAAA-/A/CCAGGT 1 -- int10--------
    rs2019523061,2
    C--21062045(+) AATTT-/CTGTTC 1 -- int10--------
    rs672524341,2
    C--21065605(+) AAGAA-/GTGGAG 1 -- int10--------
    rs1430556031,2
    C--21068093(+) CTATA-/TTAC  
            
    TTACT
    1 -- int10--------
    rs345681991,2
    C--21068096(+) CTATA-/C/TTAC
            
    TTACT
    1 -- int11NA 2
    rs1459156621,2
    C--21068124(+) CACAA-/ATTT  
            
    ATTTT
    1 -- int10--------
    rs350346041,2
    C--21094846(+) TTTTTT/-GTATT 1 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for SLCO1B1 (21284128 - 21392730 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SLCO1B1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469159CNV Loss19166990
    nsv898880CNV Loss21882294
    nsv898886CNV Loss21882294
    dgv1389n71CNV Loss21882294
    dgv1390n71CNV Loss21882294
    nsv898872CNV Loss21882294
    nsv898883CNV Loss21882294
    nsv898884CNV Loss21882294
    nsv515735CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): SLCO1B1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLCO1B1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLCO1B1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604843   
    OMIM disorders: 237450  
    UniProtKB/Swiss-Prot: SO1B1_HUMAN, Q9Y6L6
  • Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An autosomal recessive form of primary conjugated
    hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth
    or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and
    prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • Selected diseases for SLCO1B1 (see all 38):    
    About MalaCards
    hyperbilirubinemia, rotor type, digenic    rotor syndrome    bilirubin metabolic disorder    neonatal jaundice
    intrahepatic cholestasis of pregnancy    intrahepatic cholestasis    gilbert syndrome    cholestasis
    peptic ulcer    sclerosing cholangitis    primary sclerosing cholangitis    cholangitis
    neutropenia    primary biliary cirrhosis    myopathy    acute myocardial infarction
    essential hypertension    liver disease    coronary heart disease    myocardial infarction

    3 diseases from the University of Copenhagen DISEASES database for SLCO1B1:
    Bilirubin metabolic disorder     Cholestasis     Myopathy

    SLCO1B1 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for SLCO1B1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperbilirubinemia 70.5 14 15965581 (4), 19858149 (2), 20514852 (2), 15319464 (2) (see all 7)
    jaundice neonatal 65.3 2 15965581 (1), 19397531 (1)
    cholestasis 54.9 1 10500057 (1)
    g6pd deficiency 48 5 15965581 (2), 15864125 (1), 15319464 (1)
    myopathy 34.1 4 19238167 (1), 19785645 (1)
    liver diseases 32.6 5 12601360 (2), 11454187 (1)
    biliary cirrhosis primary 16.4 1 14568249 (1)
    breast cancer 9.92 4 18617601 (1), 19223659 (1), 16381673 (1), 17991769 (1)
    hepatocellular carcinoma 3.59 3 14739090 (1), 12695556 (1)
    cancer 0 4 19390945 (2), 17323126 (1)

    Genetic Association Database (GAD): SLCO1B1
    Human Genome Epidemiology (HuGE) Navigator: SLCO1B1 (129 documents)

    Export disorders for SLCO1B1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLCO1B1 gene, integrated from 10 sources (see all 319):
    (articles sorted by number of sources associating them with SLCO1B1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. (PubMed id 10358072)1, 2, 3, 7, 9 Abe T.... Yawo H. (J. Biol. Chem. 1999)
    2. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. (PubMed id 10644574)1, 2, 7, 9 Koenig J.... Keppler D. (Am. J. Physiol. 2000)
    3. A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter. (PubMed id 12196548)1, 2, 6, 9 Michalski C.... Koenig J. (J. Biol. Chem. 2002)
    4. Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans. (PubMed id 11477075)1, 2, 4, 9 Tirona R.G.... Kim R.B. (J. Biol. Chem. 2001)
    5. A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl- CoA reductase inhibitor transporters. (PubMed id 10601278)1, 2, 7, 9 Hsiang B.H....Kirchgessner T.G. (J. Biol. Chem. 1999)
    6. Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis. (PubMed id 12130747)1, 2, 4 Nozawa T....Yokoi T. (J. Pharmacol. Exp. Ther. 2002)
    7. OATP1B1 polymorphism is a major determinant of serum bilirubin level but not associated with rifampicin-mediated bilirubin elevation. (PubMed id 17973861)1, 6, 9 Zhang W....Zhou H.H. (amp 2007)
    8. Organic anion transporter protein (OATP1B1) encoded by SLCO1B1 gene polymorphism (388A&gt;G) &amp; susceptibility in gallstone disease. (PubMed id 19293444)1, 4, 9 Jindal C....Mittal B. (Indian J. Med. Res. 2009)
    9. High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). (PubMed id 15226675)1, 4, 9 Niemi M....KivistAP K.T. (Pharmacogenetics 2004)
    10. SLCO1B1 (OATP1B1, an uptake transporter) and ABCG2 (BCRP, an efflux transporter) variant alleles and pharmacokinetics of pitavastatin in healthy volunteers. (PubMed id 17460607)1, 4, 9 Ieiri I....Sugiyama Y. (Clin. Pharmacol. Ther. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10599 HGNC: 10959 AceView: SLCO1B1andLST-3 Ensembl:ENSG00000134538 euGenes: HUgn10599
    ECgene: SLCO1B1 Kegg: 10599 H-InvDB: SLCO1B1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLCO1B1 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/slco1b1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLCO1B1 gene:
    Search GeneIP for patents involving SLCO1B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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