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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLCO1B1 Gene

protein-coding   GIFtS: 63
GCID: GC12P021284

solute carrier organic anion transporter family, member...

(Previous names: solute carrier family 21 (organic anion transporter), member...)
(Previous symbol: SLC21A6)
 Explore 31 diseases affiliated with
SLCO1B1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLCO1B1    

Aliases
for SLCO1B1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Organic Anion Transporter Family, Member 1B11 2     Solute Carrier Family 21 (Organic Anion Transporter), Member 61 2
OATP1B11 2 3 5     Liver-Specific Organic Anion Transporter 12 3
LST-11 2 3     Sodium-Independent Organic Anion-Transporting Polypeptide 22 3
OATP-C1 2 3     Solute Carrier Family 21 Member 62 3
SLC21A61 2 3     OATP-22 3
LST12 3 5     HBLRR2
OATP22 3 5     Solute Carrier Organic Anion Transporter Family Member 1B12
OATPC2 3 5     

External Ids:    HGNC: 109591   Entrez Gene: 105992   Ensembl: ENSG000001345387   OMIM: 6048435   UniProtKB: Q9Y6L63   
ORGUL members:         

Export aliases for SLCO1B1 gene to outside databases

Previous GC identifers: GC12P021175 GC12P021058


Summaries
for SLCO1B1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLCO1B1:
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a
transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including
bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug
compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the
gene encoding this protein are associated with impaired transporter function. (provided by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: SO1B1_HUMAN, Q9Y6L6
Function: Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate,
dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2,
leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic
anions from the liver

Gene Wiki entry for SLCO1B1

PharmGKB "VIP" summary for SLCO1B1


Genomic Views
for SLCO1B1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLCO1B1 gene promoter:
         HOXA9B   HOXA9   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   C/EBPalpha   CREB   deltaCREB   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLCO1B1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLCO1B1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLCO1B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p   Ensembl cytogenetic band:  12p12.2   HGNC cytogenetic band: 12p12

SLCO1B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO1B1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P021284:  view genomic region     (about GC identifiers)

Start:
 21,284,128 bp from pter      End:
 21,392,730 bp from pter
Size:
 108,603 bases      Orientation:
 plus strand

Proteins
for SLCO1B1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SO1B1_HUMAN, Q9Y6L6 (See protein sequence)
Recommended Name: Solute carrier organic anion transporter family member 1B1  
Size: 691 amino acids; 76449 Da
Subcellular location: Basolateral cell membrane; Multi-pass membrane protein. Note=Detected in basolateral membranes of
hepatocytes
Secondary accessions: B2R7G2 Q29R64 Q9NQ37 Q9UBF3 Q9UH89

Explore the universe of human proteins at neXtProt for SLCO1B1: NX_Q9Y6L6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y6L6

    • SLCO1B1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006437.3  
    ENSEMBL proteins: 
     ENSP00000256958  
    Reactome Protein details: Q9Y6L6
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate: SLCO1B1
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    Novus Biologicals SLCO1B1 Protein
    Novus Biologicals SLCO1B1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLCO1B1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS10358072
    GO:0016020membrane TAS10358072
    GO:0016323basolateral plasma membrane IEA--


    SLCO1B1 for ontologies           About GeneDecksing



    SLCO1B1 Antibody Products: 
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    Uscn Antibodies for SLCO1B1
    ThermoFisher Antibody for SLCO1B1

    Assay Products for SLCO1B1: 
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    Uscn ELISAs and CLIAs for SLCO1B1

    Protein Domains /
    Families
    for SLCO1B1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLCO1B1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR002350 Prot_inh_Kazal
     IPR004156 OA_transporter
     IPR020846 MFS_dom
     IPR011497 Kazal-type_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9Y6L6

    ProtoNet protein and cluster: Q9Y6L6

    2 Blocks protein families:
    IPB004156 Organic anion transporter polypeptide (OATP)
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: SO1B1_HUMAN, Q9Y6L6
    Similarity: Belongs to the organo anion transporter (TC 2.A.60) family
    Similarity: Contains 1 Kazal-like domain


    Function
    for SLCO1B1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SO1B1_HUMAN, Q9Y6L6
    Function: Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate,
    dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2,
    leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic
    anions from the liver

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: SLCO1B1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLCO1B1
    OriGene shRNA RFP: SLCO1B1
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLCO1B1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SLCO1B1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLCO1B1
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLCO1B1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SLCO1B1 (NM_006446)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLCO1B1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLCO1B1 

    Cell Line
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    Search LifeMap BioReagents cell lines for SLCO1B1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO1B1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015347sodium-independent organic anion transmembrane transporter activity TAS10358072


    SLCO1B1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for SLCO1B1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Rosiglitazone Pharmacokinetic Pathway
    		Rosiglitazone Pharmacokinetic Pathway1.00
    		Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics0.50
    		Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics0.50
    2Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
    		Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics1.00
    		Statin Pathway - Generalized, Pharmacokinetics0.70
    		Fluvastatin Pathway, Pharmacokinetics0.80
    3Pravastatin Pathway, Pharmacokinetics
    		Pravastatin Pathway, Pharmacokinetics1.00
    		Rosuvastatin Pathway, Pharmacokinetics0.44
    		Methotrexate Pathway, Pharmacokinetics0.47
    4Transport of organic anions
    		Transport of organic anions1.00
    		Transport of vitamins, nucleosides, and related molecules0.35
    5SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SLCO1B1
        Selected targets of HNF1

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SLCO1B1
        Hepatic ABC Transporters

    2 BioSystems Pathways for SLCO1B1 
        Codeine and morphine metabolism
    Drug Induction of Bile Acid Pathway

    5/8        Reactome Pathways for SLCO1B1 (see all 8)
        Transmembrane transport of small molecules
    SLC-mediated transmembrane transport
    Transport of vitamins, nucleosides, and related molecules
    Bile acid and bile salt metabolism
    Metabolism

    5/12 PharmGKB Pathways for SLCO1B1 (see all 12)
        Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics
    Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics
    Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
    Codeine and Morphine Pathway, Pharmacokinetics
    Fluvastatin Pathway, Pharmacokinetics

    1         Kegg Pathway  (Kegg details for SLCO1B1):
        Bile secretion


    SLCO1B1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLCO1B1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLCO1B1 (ENSP000002569584) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCB11ENSP000002638174STRING: ENSP00000263817
    ABCC3ENSP000002852384STRING: ENSP00000285238
    ALBENSP000002958974STRING: ENSP00000295897
    FABP6ENSP000003775494STRING: ENSP00000377549
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008206bile acid metabolic process TAS--
    GO:0015711organic anion transport TAS10358072
    GO:0015721bile acid and bile salt transport TAS--
    GO:0043252sodium-independent organic anion transport TAS--
    GO:0044281small molecule metabolic process TAS--


    SLCO1B1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLCO1B1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLCO1B1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SLCO1B1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    EstropipateEstrogen receptor agonist and OATP1B1 inhibitor[7280-37-7]

    10/93 HMDB Compounds for SLCO1B1 (see all 93)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acidChenodeoxycholic acid 3-glucuronide (see all 3)58814-71-412196548
    1,3,12-Trihydroxycholan-24-oic acid1,3,12-Trihydroxycholan-24-oate (see all 6)63266-91-112196548
    1,3,7,12-Tetrahydroxycholan-24-oic acid1,3,7,12-Tetrahydroxycholan-24-oate (see all 10)63266-89-712196548
    12-Ketodeoxycholic acid12-Dehydrodeoxycholate (see all 20)5130-29-012196548
    12a-Hydroxy-3-oxocholadienic acid12a-Hydroxy-3-oxo-4,6-choladien-24-oate (see all 8)13535-96-112196548
    12b-Hydroxy-5b-cholanoic acid12b-Hydroxy-5b-cholanic acid (see all 9)15173-23-612196548
    1b,3a,12a-Trihydroxy-5b-cholanoic acid1,3,12-trihydroxy-(5b)-Cholan-24-oate (see all 6)80434-32-812196548
    1b,3a,7a-Trihydroxy-5b-cholanoic acid1 beta,3a,7a-Trihydroxy-5b-cholanoate (see all 18)99598-04-612196548
    1b-Hydroxycholic acid1b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 5)80875-94-112196548
    2b,3a,7a,12a-Tetrahydroxy-5b-cholanoic acid2b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 7)60696-60-812196548

    10/43 DrugBank Compounds for SLCO1B1 (see all 43)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Conjugated EstrogensEstrogens (see all 10)438-67-5transportersubstrate inhibitor12101011 11683238 15159445 14977862 12906759 15901800 11134001
    Digoxin-- 20830-75-5transportersubstrate inhibitor12101011 11408557 11451172 11883641 11257421 11818398
    PravastatinPravastatin Sodium (see all 4)81093-37-0transportersubstrate inhibitor10601278 19919292 15616150 15970799 15901800
    Taurocholic Acid-- 81-24-3transportersubstrate inhibitor inducer10358072 10601278 12235261 12906759 11134001
    CyclosporineCiclosporin (see all 3)59865-13-3transporterinhibitor12538813 14530907 12490595 12906759
    RifampinRFP (see all 3)13292-46-1transporterinhibitor12085361 19919292 12490595 11134001
    Cholic Acid-- 81-25-4transportersubstrate inhibitor inducer10644574 12235261 11134001
    Atorvastatin-- 134523-00-5transportersubstrate inhibitor10601278 15970799
    CerivastatinCerivastatin sodium (see all 2)145599-86-6transportersubstrate15970799 15901800
    DinoprostoneDinoprostone Prostaglandin E2 (see all 3)363-24-6transportersubstrate10358072 10873595

    10/28 Novoseek chemical compound relationships for SLCO1B1 gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oatp 91.9 31 12542534 (2), 19661216 (2), 19785645 (2), 10644574 (2) (see all 12)
    estradiol-17beta-glucuronide 84.2 1 15564882 (1)
    taurocholate 81.9 8 12196548 (1), 16637898 (1), 11408557 (1), 17989996 (1) (see all 8)
    pravastatin 79.4 53 17177112 (7), 16678544 (5), 15864131 (5), 11356905 (4) (see all 15)
    estrone sulfate 78.6 7 17918775 (2), 17641954 (1), 15159445 (1), 11477075 (1)
    androstane 73.8 2 15382119 (1), 18334180 (1)
    repaglinide 66.8 15 15961978 (3), 16198658 (2), 16796707 (1), 19785645 (1)
    rosuvastatin 65.7 5 15289793 (2), 15116058 (2), 18617601 (1)
    uridine diphosphate 59.6 2 19238116 (1)
    bromosulfophthalein 58.5 2 17989996 (1), 10644574 (1)

    10/13 PharmGKB related drug/compound annotations for SLCO1B1 gene (see all 13)
    Drug/compound PharmGKB Annotation
    atorvastatinCA  
    cerivastatinCA  
    fluvastatinCA  
    hmg coa reductase inhibitorsCA  
    methotrexateCA  
    nateglinideCA  
    pravastatinCA  
    repaglinideCA  
    rifampinCA  
    rosuvastatinCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about SLCO1B1 / SO1B1 

    Transcripts
    for SLCO1B1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLCO1B1 gene: 
    NM_006446.4  

    Unigene Cluster for SLCO1B1:

    Solute carrier organic anion transporter family, member 1B1
    Hs.449738  [show with all ESTs]
    Unigene Representative Sequence: AF205071
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000256958(uc001req.4)

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: SLCO1B1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLCO1B1
    OriGene shRNA RFP: SLCO1B1
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    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLCO1B1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SLCO1B1 (NM_006446)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLCO1B1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLCO1B1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLCO1B1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLCO1B1

    Additional cDNA sequence: 

    AB026257.1 AF060500.1 AF205071.1 AJ132573.1 AK312970.1 BC005243.2 BC020696.1 BC054878.1 
    BC070172.1 BC105596.1 BC114376.1 

    2 DOTS entries:

    DT.430127  DT.92431204 

    24/40 AceView cDNA sequences (see all 40):

    CB161434 BG618727 CB163667 CB161880 AB026257 AA382692 CB161473 BX283296 
    BG562880 BG566359 BG569386 CB163230 BG569568 BC005243 AF060500 BG567055 
    NM_006446 AF205071 AJ132573 CB147672 BX507379 BC020696 CB164145 BX495197 

    GeneLoc Exon Structure


    Expression
    for SLCO1B1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLCO1B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTACTGTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SLCO1B1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLCO1B1

    SOURCE GeneReport for Unigene cluster: Hs.449738

    UniProtKB/Swiss-Prot: SO1B1_HUMAN, Q9Y6L6
    Tissue specificity: Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Not detected
    in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small
    intestine, colon and leukocyte

        SABiosciences Expression via Pathway-Focused PCR Array including SLCO1B1: 
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    Orthologs
    for SLCO1B1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLCO1B1 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLCO1B11 solute carrier organic anion transporter family, member more 60.3(n)
    50.73(a)    		   418187  XM_416418.3  XP_416418.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 45(a)
    		 1 → many
    		 5(8412701-8428198)
    zebrafish
    (Danio rerio)    		 Actinopterygii slco1f16
    slco1f46
    (see all 6)    		 solute carrier organic anion transporter family, m...
    solute carrier organic anion transporter family, m...
    (see all 6)    		 43(a)
    43(a)
    (see all 6)    		 possible ortholog
    possible ortholog
    (see all 6)    		 5(62638038-62646208)
    4(60470768-60490279)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Oatp58Da6
    Oatp58Db6
    (see all 7)    		 Organic anion transporting polypeptide 58Db
    (see all 7)    		 21(a)
    20(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 2R(18105961-18108393)
    2R(18108685-18111095)
    worm
    (Caenorhabditis elegans)    		 Secernentea F21G4.16
    F47E1.46
    (see all 4)    		 Protein F47E1.4
    (see all 4)    		 23(a)
    21(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 X(9889257-9892270)
    X(9062779-9066602)


    ENSEMBL Gene Tree for SLCO1B1 (if available)
    TreeFam Gene Tree for SLCO1B1 (if available) 

    Paralogs
    for SLCO1B1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLCO1B1 gene
    SLCO2A12  SLCO4C12  SLCO1B72  ENSG000002570622  SLCO3A12  SLCO1B32  SLCO5A12  SLCO2B12  
    SLCO6A12  ENSG000002570462  SLCO4A12  SLCO1A22  SLCO1C12  
    12 SIMAP similar genes for SLCO1B1 using alignment to 8 protein entries:     SO1B1_HUMAN (see all proteins):
    SLCO1B3    SLC21A8    LST3    SLCO1B7    SLCO1A2    SLCO1C1
    SLCO3A1    SLCO2B1    SLCO2A1    SLCO5A1    SLCO4C1    SLCO4A1

    SLCO1B1 for paralogs           About GeneDecksing



    Genomic Variants
    for SLCO1B1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2330 NCBI SNPs in SLCO1B1 are shown (see all 2330)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1396912451,2
    		Cother21105811(+) TCCAAT/ACATTG 2 /N /I mis11Minor allele frequency- A:0.00NA 4506
    rs792411141,2
    		F,--21056166(+) ACTAAA/CTCTTT 1 -- us2k11Minor allele frequency- C:0.09WA 118
    rs582080201,2
    		F,--21056370(+) AATCAA/GTTTTT 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs173287631,2
    		C,F,H,--21056466(+) TTCCAT/CGATCC 1 -- us2k128Minor allele frequency- C:0.11NA NS EA CSA 4063
    rs730603641,2
    		--21056809(+) GGCAGA/TACATG 1 -- us2k10--------
    rs767755141,2
    		F,--21056834(+) TGCTTA/TTTTAA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs557475261,2
    		C,F,--21056868(+) AGCCAG/CAATCT 1 -- us2k13Minor allele frequency- C:0.05WA 122
    rs593101111,2
    		F,--21057146(+) GAATGA/GTAAGG 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs789065651,2
    		C,--21057638(+) ACTTAT/CGTACC 1 -- us2k14Minor allele frequency- C:0.00NA 536
    rs597103861,2
    		C,F,--21057906(+) TGGCAA/CCTGGA 1 -- us2k16Minor allele frequency- C:0.02NA 1172

    HapMap Linkage Disequilibrium report for SLCO1B1 (21284128 - 21392730 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SLCO1B1
         2 CNVs: 49020 49025
    Human Gene Mutation Database (HGMD): SLCO1B1

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    Disorders / Diseases
    for SLCO1B1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLCO1B1 for disorders           About GeneDecksing

    OMIM gene information: 604843    OMIM disorders: --

    UniProtKB/Swiss-Prot: SO1B1_HUMAN, Q9Y6L6
  • Defects in SLCO1B1 are a cause of hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]. An autosomal recessive
    • form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with
    hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye
    bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal

    20/31 diseases for SLCO1B1 (see all 31):    About MalaCards
    sclerosing cholangitis    primary sclerosing cholangitis    intrahepatic cholestasis    primary biliary cirrhosis
    neonatal jaundice    cholestasis    cholangitis    jaundice
    myocardial infarction    acute myocardial infarction    coronary heart disease    gilbert syndrome
    essential hypertension    liver disease    hepatocellular carcinoma    rheumatoid arthritis
    myopathy    neutropenia    breast cancer    hypertension

    3 diseases from the University of Copenhagen DISEASES database for SLCO1B1:
    Bilirubin metabolic disorder     Cholestasis     Myopathy

    10 Novoseek disease relationships for SLCO1B1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperbilirubinemia 70.5 14 15965581 (4), 19858149 (2), 20514852 (2), 15319464 (2) (see all 7)
    jaundice neonatal 65.3 2 15965581 (1), 19397531 (1)
    cholestasis 54.9 1 10500057 (1)
    g6pd deficiency 48 5 15965581 (2), 15864125 (1), 15319464 (1)
    myopathy 34.1 4 19238167 (1), 19785645 (1)
    liver diseases 32.6 5 12601360 (2), 11454187 (1)
    biliary cirrhosis primary 16.4 1 14568249 (1)
    breast cancer 9.92 4 18617601 (1), 19223659 (1), 16381673 (1), 17991769 (1)
    hepatocellular carcinoma 3.59 3 14739090 (1), 12695556 (1)
    cancer 0 4 19390945 (2), 17323126 (1)

    Genetic Association Database (GAD): SLCO1B1
    Human Genome Epidemiology (HuGE) Navigator: SLCO1B1 (129 documents)

    Export disorders for SLCO1B1 gene to outside databases

    Publications
    for SLCO1B1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLCO1B1 gene, integrated from 9 sources (see all 280):
    (articles sorted by number of sources associating them with SLCO1B1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. (PubMed id 10358072)1, 2, 3, 7, 9 Abe T.... Yawo H. (1999)
    2. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. (PubMed id 10644574)1, 2, 7, 9 Koenig J.... Keppler D. (2000)
    3. A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter. (PubMed id 12196548)1, 2, 6, 9 Michalski C.... Koenig J. (2002)
    4. Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans. (PubMed id 11477075)1, 2, 4, 9 Tirona R.G.... Kim R.B. (2001)
    5. A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl- CoA reductase inhibitor transporters. (PubMed id 10601278)1, 2, 7, 9 Hsiang B.H....Kirchgessner T.G. (1999)
    6. Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis. (PubMed id 12130747)1, 2, 4 Nozawa T....Yokoi T. (2002)
    7. OATP1B1 polymorphism is a major determinant of serum bilirubin level but not associated with rifampicin-mediated bilirubin elevation. (PubMed id 17973861)1, 6, 9 Zhang W....Zhou H.H. (2007)
    8. High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). (PubMed id 15226675)1, 4, 9 Niemi M....Kivisto K.T. (2004)
    9. Acute effects of pravastatin on cholesterol synthesis are associated with SLCO1B1 (encoding OATP1B1) haplotype *17. (PubMed id 15864131)1, 4, 9 Niemi M....Kivisto K.T. (2005)
    10. Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics. (PubMed id 12811365)1, 4, 9 Nishizato Y.... Sugiyama Y. (2003)

    External Searches for SLCO1B1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing SLCO1B1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10599 HGNC: 10959 AceView: SLCO1B1andLST-3 Ensembl:ENSG00000134538 euGenes: HUgn10599
    ECgene: SLCO1B1 Kegg: 10599 H-InvDB: SLCO1B1

    Other Databases showing SLCO1B1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLCO1B1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLCO1B1 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/slco1b1/

    Intellectual Property
    for SLCO1B1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLCO1B1 gene:
    Search GeneIP for patents involving SLCO1B1

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