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Aliases for SLCO1A2 Gene

Aliases for SLCO1A2 Gene

  • Solute Carrier Organic Anion Transporter Family, Member 1A2 2 3
  • SLC21A3 3 4 6
  • OATP 3 4 6
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 3 2 3
  • Sodium-Independent Organic Anion Transporter 3 4
  • Organic Anion-Transporting Polypeptide 1 3 4
  • Solute Carrier Family 21 Member 3 3 4
  • OATP1A2 3 4
  • OATP-1 3 4
  • OATP-A 3 4
  • Solute Carrier Organic Anion Transporter Family Member 1A2 3
  • Organic Anion Transporting Polypeptide A 3
  • OATP1 4

External Ids for SLCO1A2 Gene

Previous HGNC Symbols for SLCO1A2 Gene

  • SLC21A3

Previous GeneCards Identifiers for SLCO1A2 Gene

  • GC12M021313
  • GC12M021417

Summaries for SLCO1A2 Gene

Entrez Gene Summary for SLCO1A2 Gene

  • This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]

GeneCards Summary for SLCO1A2 Gene

SLCO1A2 (Solute Carrier Organic Anion Transporter Family, Member 1A2) is a Protein Coding gene. Diseases associated with SLCO1A2 include aneurysmal bone cysts and intrahepatic cholestasis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include organic anion transmembrane transporter activity. An important paralog of this gene is SLCO1B7.

UniProtKB/Swiss-Prot for SLCO1A2 Gene

  • Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.

Gene Wiki entry for SLCO1A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO1A2 Gene

Genomics for SLCO1A2 Gene

Regulatory Elements for SLCO1A2 Gene

Genomic Location for SLCO1A2 Gene

Start:
21,264,600 bp from pter
End:
21,419,594 bp from pter
Size:
154,995 bases
Orientation:
Minus strand

Genomic View for SLCO1A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLCO1A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO1A2 Gene

Proteins for SLCO1A2 Gene

  • Protein details for SLCO1A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46721-SO1A2_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 1A2
    Protein Accession:
    P46721
    Secondary Accessions:
    • Q9UGP7
    • Q9UL38

    Protein attributes for SLCO1A2 Gene

    Size:
    670 amino acids
    Molecular mass:
    74145 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLCO1A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLCO1A2 Gene

Proteomics data for SLCO1A2 Gene at MOPED

Post-translational modifications for SLCO1A2 Gene

  • Glycosylation at Asn124, Asn135, Asn412, and Asn419
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLCO1A2 Gene

Domains for SLCO1A2 Gene

Gene Families for SLCO1A2 Gene

Graphical View of Domain Structure for InterPro Entry

P46721

UniProtKB/Swiss-Prot:

SO1A2_HUMAN :
  • P46721
Domain:
  • Contains 1 Kazal-like domain.
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO1A2: view

Function for SLCO1A2 Gene

Molecular function for SLCO1A2 Gene

UniProtKB/Swiss-Prot Function: Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.

Gene Ontology (GO) - Molecular Function for SLCO1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005515 protein binding --
GO:0008514 organic anion transmembrane transporter activity TAS 9007731
genes like me logo Genes that share ontologies with SLCO1A2: view

Phenotypes for SLCO1A2 Gene

genes like me logo Genes that share phenotypes with SLCO1A2: view

Animal Models for SLCO1A2 Gene

MGI Knock Outs for SLCO1A2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLCO1A2 Gene

Localization for SLCO1A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO1A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLCO1A2 Gene COMPARTMENTS Subcellular localization image for SLCO1A2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLCO1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLCO1A2: view

Pathways for SLCO1A2 Gene

genes like me logo Genes that share pathways with SLCO1A2: view

Gene Ontology (GO) - Biological Process for SLCO1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0008206 bile acid metabolic process TAS --
GO:0015711 organic anion transport TAS 9007731
GO:0015721 bile acid and bile salt transport TAS --
GO:0043252 sodium-independent organic anion transport TAS --
genes like me logo Genes that share ontologies with SLCO1A2: view

Compounds for SLCO1A2 Gene

(85) HMDB Compounds for SLCO1A2 Gene

Compound Synonyms Cas Number PubMed IDs
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
58814-71-4
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-oate
63266-91-1
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-oate
63266-89-7
12a-Hydroxy-3-oxocholadienic acid
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oate
13535-96-1
12b-Hydroxy-5b-cholanoic acid
  • 12b-Hydroxy-5b-cholanic acid
15173-23-6

(60) Drugbank Compounds for SLCO1A2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Aldosterone
  • (+)-aldosterone
52-39-1 transporter inhibitor
Aminohippurate
  • Aminohippurate Sodium
94-16-6 transporter substrate
Atorvastatin
134523-00-5 transporter inhibitor
Bumetanide
  • Bumetanida [INN-Spanish]
28395-03-1 transporter substrate
Chlorambucil
  • Chlocambucil
305-03-3 transporter

(6) IUPHAR Ligand for SLCO1A2 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]estrone-3-sulphate None None
naringin Inhibitor Inhibition
rifampicin Inhibitor Inhibition
[3H]BSP None None
rifamycin SV Inhibitor Inhibition
[3H]DPDPE None None

(11) Novoseek inferred chemical compound relationships for SLCO1A2 Gene

Compound -log(P) Hits PubMed IDs
oatp 96.4 38
estrone sulfate 84.8 3
taurocholate 82.2 6
deltorphin ii 73.6 2
bromosulfophthalein 69.7 2
genes like me logo Genes that share compounds with SLCO1A2: view

Transcripts for SLCO1A2 Gene

Unigene Clusters for SLCO1A2 Gene

Solute carrier organic anion transporter family, member 1A2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO1A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17
SP1: - -
SP2:
SP3: -
SP4: -

Relevant External Links for SLCO1A2 Gene

GeneLoc Exon Structure for
SLCO1A2
ECgene alternative splicing isoforms for
SLCO1A2

Expression for SLCO1A2 Gene

mRNA expression in normal human tissues for SLCO1A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO1A2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (8.9), Brain - Substantia nigra (7.3), Brain - Hippocampus (6.8), Brain - Amygdala (6.3), Brain - Putamen (basal ganglia) (5.0), and Brain - Hypothalamus (4.6).

SOURCE GeneReport for Unigene cluster for SLCO1A2 Gene Hs.46440

genes like me logo Genes that share expressions with SLCO1A2: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for SLCO1A2 Gene

Orthologs for SLCO1A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLCO1A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLCO1A2 35
  • 99.3 (n)
  • 99.25 (a)
SLCO1A2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLCO1A2 35
  • 87.64 (n)
  • 83.03 (a)
SLCO1A2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OATPA 36
  • 87 (a)
OneToOne
SLCO1A2 35
  • 89.65 (n)
  • 86.72 (a)
mouse
(Mus musculus)
Mammalia Gm5724 36
  • 66 (a)
OneToMany
Gm6614 36
  • 67 (a)
OneToMany
Slco1a1 36
  • 69 (a)
OneToMany
Slco1a4 36
  • 73 (a)
OneToMany
Slco1a5 35
  • 78.11 (n)
  • 72.54 (a)
Slco1a5 16
Slco1a5 36
  • 73 (a)
OneToMany
Slco1a6 36
  • 66 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SLCO1A2 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slco1a5 35
  • 77.66 (n)
  • 72.39 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 57 (a)
OneToMany
SLCO1A2 35
  • 65.53 (n)
  • 58.29 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC68666 35
Species with no ortholog for SLCO1A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLCO1A2 Gene

ENSEMBL:
Gene Tree for SLCO1A2 (if available)
TreeFam:
Gene Tree for SLCO1A2 (if available)

Paralogs for SLCO1A2 Gene

genes like me logo Genes that share paralogs with SLCO1A2: view

Variants for SLCO1A2 Gene

Sequence variations from dbSNP and Humsavar for SLCO1A2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs4078 -- 21,324,049(+) GAAGT(A/G)AACCA intron-variant
rs4088 -- 21,324,099(+) AGTAT(G/T)TGTGT intron-variant
rs722994 -- 21,294,132(-) CTATG(A/G)CATTA intron-variant
rs764906 -- 21,360,342(+) taaaa(C/T)GACAC intron-variant
rs875234 -- 21,265,117(-) ATTAC(A/G)CTCAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLCO1A2 Gene

Variant ID Type Subtype PubMed ID
nsv515735 CNV Gain+Loss 19592680
nsv898883 CNV Loss 21882294
dgv1390n71 CNV Loss 21882294
nsv898886 CNV Loss 21882294
nsv898889 CNV Loss 21882294
nsv898890 CNV Loss 21882294
dgv1391n71 CNV Loss 21882294
nsv898893 CNV Loss 21882294
esv1146701 CNV Insertion 17803354
nsv469161 CNV Loss 19166990
esv2750499 CNV Gain 17666407
nsv519603 CNV Gain+Loss 19592680
nsv470274 CNV Loss 18288195
nsv469162 CNV Loss 19166990
nsv898894 CNV Loss 21882294

Relevant External Links for SLCO1A2 Gene

HapMap Linkage Disequilibrium report
SLCO1A2
Human Gene Mutation Database (HGMD)
SLCO1A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO1A2 Gene

Disorders for SLCO1A2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SLCO1A2 Gene including...

Search for SLCO1A2 Gene in MalaCards »

(1) Novoseek inferred disease relationships for SLCO1A2 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for SLCO1A2

Genetic Association Database (GAD)
SLCO1A2
Human Genome Epidemiology (HuGE) Navigator
SLCO1A2
genes like me logo Genes that share disorders with SLCO1A2: view

No data available for UniProtKB/Swiss-Prot for SLCO1A2 Gene

Publications for SLCO1A2 Gene

  1. Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. (PMID: 15632119) Lee W. … Kim R.B. (J. Biol. Chem. 2005) 3 4 23 48
  2. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. (PMID: 7557095) Kullak-Ublick G.-A. … Meier P.J. (Gastroenterology 1995) 3 4 25
  3. Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney. (PMID: 18466105) ZaA^r Z.M. … Kullak-Ublick G.A. (Pharmacogenomics 2008) 3 23
  4. HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms. (PMID: 20051929) Hartkoorn R.C. … Owen A. (Pharmacogenet. Genomics 2010) 3 23
  5. Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12p12 by fluorescence in situ hybridization. (PMID: 9007731) Kullak-Ublick G.A. … Paumgartner G. (J. Hepatol. 1996) 2 3

Products for SLCO1A2 Gene

  • antibodies-online peptides for SLCO1A2
  • antibodies-online antibodies for SLCO1A2
  • antibodies-online kits for SLCO1A2

Sources for SLCO1A2 Gene

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