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SLCO1A2 Gene

protein-coding   GIFtS: 62
GCID: GC12M021417

Solute Carrier Organic Anion Transporter Family, Member...

(Previous names: solute carrier family 21 (organic anion transporter), member...)
(Previous symbol: SLC21A3)
  See SLCO1A2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Solute Carrier Organic Anion Transporter Family, Member 1A21 2     OATP-12 3
SLC21A31 2 3 5     OATP-A2 3
OATP2 3 5     OATP1A22 3
Solute Carrier Family 21 (Organic Anion Transporter), Member 31 2     Organic Anion Transporting Polypeptide A2
Organic Anion-Transporting Polypeptide 12 3     Solute Carrier Organic Anion Transporter Family Member 1A22
Sodium-Independent Organic Anion Transporter2 3     OATP13
Solute Carrier Family 21 Member 32 3     

External Ids:    HGNC: 109561   Entrez Gene: 65792   Ensembl: ENSG000000844537   OMIM: 6028835   UniProtKB: P467213   
ORGUL members:         

Export aliases for SLCO1A2 gene to outside databases

Previous GC identifers: GC12M021313 GC12M021191


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLCO1A2 Gene:
This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver.
Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of
the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants.
(provided by RefSeq, Dec 2008)

GeneCards Summary for SLCO1A2 Gene:
SLCO1A2 (solute carrier organic anion transporter family, member 1A2) is a protein-coding gene. Diseases associated with SLCO1A2 include aneurysmal bone cysts. GO annotations related to this gene include organic anion transmembrane transporter activity. An important paralog of this gene is SLCO2A1.

UniProtKB/Swiss-Prot: SO1A2_HUMAN, P46721
Function: Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and
conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the
grapefruit juice component naringin

Gene Wiki entry for SLCO1A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLCO1A2 gene promoter:
         STAT3   HNF-4alpha2   NF-kappaB   NF-kappaB1   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLCO1A2 promoter sequence
   Search Chromatin IP Primers for SLCO1A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLCO1A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12   Ensembl cytogenetic band:  12p12.1   HGNC cytogenetic band: 12p12

SLCO1A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO1A2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M021417:  view genomic region     (about GC identifiers)

Start:
21,417,534 bp from pter      End:
21,572,528 bp from pter
Size:
154,995 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SO1A2_HUMAN, P46721 (See protein sequence)
Recommended Name: Solute carrier organic anion transporter family member 1A2  
Size: 670 amino acids; 74145 Da
Secondary accessions: Q9UGP7 Q9UL38
Alternative splicing: 2 isoforms:  P46721-1   P46721-2   

Explore the universe of human proteins at neXtProt for SLCO1A2: NX_P46721

Explore proteomics data for SLCO1A2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn124, Asn135, Asn412, Asn419
  • Modification sites at PhosphoSitePlus

  • See SLCO1A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_066580.1  NP_602307.1  

    ENSEMBL proteins: 
     ENSP00000305974   ENSP00000440154   ENSP00000394854   ENSP00000438348   ENSP00000403638  
     ENSP00000416190   ENSP00000409314   ENSP00000390572   ENSP00000407462   ENSP00000401195  
     ENSP00000409691   ENSP00000390672   ENSP00000392124   ENSP00000410338   ENSP00000393973  
     ENSP00000439401   ENSP00000375088  
    Reactome Protein details: P46721

    SLCO1A2 Human Recombinant Protein Products:

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    Novus Biologicals SLCO1A2 Lysates
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    Cloud-Clone Corp. Proteins for SLCO1A2

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: OATP1A2
    SLCO family of organic anion transporting polypeptides

    4 InterPro protein domains:
     IPR002350 Kazal_dom
     IPR004156 OA_transporter
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry P46721

    ProtoNet protein and cluster: P46721

    2 Blocks protein domains:
    IPB004156 Organic anion transporter polypeptide (OATP)
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: SO1A2_HUMAN, P46721
    Similarity: Belongs to the organo anion transporter (TC 2.A.60) family
    Similarity: Contains 1 Kazal-like domain


    Find genes that share domains with SLCO1A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SO1A2_HUMAN, P46721
    Function: Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and
    conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the
    grapefruit juice component naringin

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005515protein binding ----
    GO:0008514organic anion transmembrane transporter activity TAS9007731
         
    Find genes that share ontologies with SLCO1A2           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slco1a5):
     hematopoietic system  immune system 

    Find genes that share phenotypes with SLCO1A2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slco1a5tm1Lex for SLCO1A2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLCO1A2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLCO1A2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLCO1A2

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate SLCO1A2:
    hsa-miR-320a hsa-miR-382 hsa-miR-320b hsa-let-7g* hsa-miR-3121-3p hsa-miR-320d hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): SLCO1A2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLCO1A2
    Predesigned siRNA for gene silencing in human, mouse, rat SLCO1A2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): SLCO1A2 (NM_134431)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLCO1A2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLCO1A2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO1A2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SO1A2_HUMAN, P46721: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLCO1A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLCO1A2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Synthesis of bile acids and bile salts
    Bile acid and bile salt metabolism0.73
    Recycling of bile acids and salts0.00
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transmembrane transport of small molecules0.47
    3Methotrexate Pathway, Pharmacokinetics
    Methotrexate Pathway (Brain Cell), Pharmacokinetics0.43
    Methotrexate Pathway, Pharmacokinetics0.43
    4Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    5Transport of vitamins, nucleosides, and related molecules
    Transport of organic anions0.00
    Transport of vitamins, nucleosides, and related molecules


    Find genes that share SuperPaths with SLCO1A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SLCO1A2
        Hepatic ABC Transporters

    2 Reactome Pathways for SLCO1A2
        Recycling of bile acids and salts
    Transport of organic anions

    3 PharmGKB Pathways for SLCO1A2
        Methotrexate Pathway (Brain Cell), Pharmacokinetics
    Methotrexate Pathway, Pharmacokinetics
    Statin Pathway - Generalized, Pharmacokinetics

    1 Kegg Pathway  (Kegg details for SLCO1A2):
        Bile secretion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLCO1A2: 
              Growth Factors in human mouse rat
              Drug Transporters in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLCO1A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for SLCO1A2 (P467213 ENSP000003059744) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A3R1O147453, ENSP000002626134I2D: score=1 STRING: ENSP00000262613
    PDZK1Q5T2W13, ENSP000003421434I2D: score=1 STRING: ENSP00000342143
    SLC9A3R2Q155993, ENSP000004080054I2D: score=1 STRING: ENSP00000408005
    ABCB11ENSP000002638174STRING: ENSP00000263817
    ABCC3ENSP000002852384STRING: ENSP00000285238
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0008206bile acid metabolic process TAS--
    GO:0015711organic anion transport TAS9007731
    GO:0015721bile acid and bile salt transport TAS--
    GO:0043252sodium-independent organic anion transport TAS--

    Find genes that share ontologies with SLCO1A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLCO1A2 (SO1A2)

    Selected HMDB Compounds for SLCO1A2 (see all 85)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acidChenodeoxycholic acid 3-glucuronide (see all 3)58814-71-4--
    1,3,12-Trihydroxycholan-24-oic acid1,3,12-Trihydroxycholan-24-oate (see all 6)63266-91-1--
    1,3,7,12-Tetrahydroxycholan-24-oic acid1,3,7,12-Tetrahydroxycholan-24-oate (see all 10)63266-89-7--
    12-Ketodeoxycholic acid12-Dehydrodeoxycholate (see all 20)5130-29-0--
    12a-Hydroxy-3-oxocholadienic acid12a-Hydroxy-3-oxo-4,6-choladien-24-oate (see all 8)13535-96-1--
    12b-Hydroxy-5b-cholanoic acid12b-Hydroxy-5b-cholanic acid (see all 9)15173-23-6--
    1b,3a,12a-Trihydroxy-5b-cholanoic acid1,3,12-trihydroxy-(5b)-Cholan-24-oate (see all 6)80434-32-8--
    1b,3a,7a-Trihydroxy-5b-cholanoic acid1 beta,3a,7a-Trihydroxy-5b-cholanoate (see all 18)99598-04-6--
    1b-Hydroxycholic acid1b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 5)80875-94-1--
    2b,3a,7a,12a-Tetrahydroxy-5b-cholanoic acid2b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 7)60696-60-8--

    Selected DrugBank Compounds for SLCO1A2 (see all 60)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Taurocholic Acid-- 81-24-3transportersubstrate inhibitor inducer8045503 7557095 8786566 11408557 10198348 8779894 12399219 9918568 10601278 8779893 12702494 12235261 8968376 8621133 9632674 12842829 10381771 12518026 10600646 11408531 9334206 9794920
    Conjugated EstrogensEstrogens (see all 10)438-67-5transportersubstrate inhibitor9539145 8786566 10871297 10198348 8779894 9918568 8938553 12702494 8968376 10600646 9794920
    Cholic Acid-- 81-25-4transportersubstrate inhibitor inducer8278353 8045503 7557095 10198348 9918568 8779893 11438506 12842829
    OuabainG-Strophanthin (see all 7)630-60-4transportersubstrate inhibitor8786566 11159893 10198348 8938553 9632674 10600646
    Quinidine-- 56-54-2transporterinhibitor10421612 11883641 10490898 11408531
    RifampinRFP (see all 3)13292-46-1transporterinhibitor12085361 11883641 10869292 10381771
    Ursodeoxycholic acid(3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid (see all 18)128-13-2transportersubstrate inhibitor inducer8045503 7557095 11438506 12842829
    DinoprostoneDinoprostone Prostaglandin E2 (see all 3)363-24-6transportersubstrate11159893 8779893 11713643
    Estradiol17beta oestradiol (see all 7)50-28-2transporterinhibitor8786566 11159893 8779894
    LiothyronineL-Liothyronine (see all 5)6893-02-3transportersubstrate11316767 11159893 9918867

    6 IUPHAR Ligands for SLCO1A2 (OATP1A2)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]estrone-3-sulphate
    NoneNone--
    naringin
    InhibitorInhibition--
    rifampicin
    InhibitorInhibition--
    [3H]BSP
    NoneNone--
    rifamycin SV
    InhibitorInhibition--
    [3H]DPDPE
    NoneNone--

    Selected Novoseek inferred chemical compound relationships for SLCO1A2 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oatp 96.4 57 11901224 (5), 8990200 (5), 11897630 (4), 12542534 (2) (see all 23)
    estrone sulfate 84.8 3 15832500 (1), 19010908 (1), 15632119 (1)
    taurocholate 82.2 8 8904218 (1), 16637898 (1), 11408557 (1), 16611857 (1) (see all 6)
    deltorphin ii 73.6 3 10871297 (1), 15632119 (1)
    bromosulfophthalein 69.7 2 8572210 (1), 15650133 (1)
    fexofenadine 69.2 6 17215845 (4), 16014768 (1)
    pravastatin 56.4 4 16611857 (1), 10601278 (1)
    digoxin 50.6 2 16611857 (1)
    probenecid 45.8 1 11408557 (1)
    prostaglandin 34.7 5 14631946 (1), 10601278 (1), 10873595 (1)



    Find genes that share compounds with SLCO1A2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLCO1A2 gene (3 alternative transcripts): 
    NM_021094.3  NM_134431.3  NM_005075.2  

    Unigene Cluster for SLCO1A2:

    Solute carrier organic anion transporter family, member 1A2
    Hs.46440  [show with all ESTs]
    Unigene Representative Sequence: NM_134431
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000307378(uc010sio.2 uc001res.3 uc010siq.2) ENST00000544020
    ENST00000458504 ENST00000544290 ENST00000480394(uc001reu.2) ENST00000463718(uc001ret.3)
    ENST00000413682 ENST00000422327 ENST00000453443 ENST00000473830 ENST00000421294
    ENST00000450590 ENST00000435179 ENST00000445053 ENST00000421287 ENST00000416627
    ENST00000430803 ENST00000452078(uc001rer.3 uc010sip.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat SLCO1A2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate SLCO1A2:
    hsa-miR-320a hsa-miR-382 hsa-miR-320b hsa-let-7g* hsa-miR-3121-3p hsa-miR-320d hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): SLCO1A2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SLCO1A2
    Predesigned siRNA for gene silencing in human, mouse, rat SLCO1A2
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    OriGene ORF clones in mouse, rat for SLCO1A2
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    GenScript: all cDNA clones in your preferred vector (see all 2): SLCO1A2 (NM_134431)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLCO1A2
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat SLCO1A2
      QuantiFast Probe-based Assays in human, mouse, rat SLCO1A2

    Additional mRNA sequence: 

    AF279784.1 AK296044.1 AK316249.1 BC144256.1 U21943.1 

    14 DOTS entries:

    DT.100742569  DT.91963539  DT.95367785  DT.301466  DT.307481  DT.121183641  DT.121183647  DT.97836928 
    DT.92418196  DT.121183651  DT.121183667  DT.121183684  DT.92418195  DT.121183662 

    Selected AceView cDNA sequences (see all 25):

    AF279784 U21943 CA314457 AL589319 NM_134431 NM_021094 NM_005075 BX282641 
    AF085224 BI668292 BC042452 AL705820 BX955947 BI547522 BG701767 N80085 
    BG204113 AI632103 BI550525 BF945519 BG699366 N62948 BG701848 AI557639 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLCO1A2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17
    SP1:                                            -                                                                             -         
    SP2:                                                                                                                                    
    SP3:                    -                                                                                                               
    SP4:                    -                                                                                                               


    ECgene alternative splicing isoforms for SLCO1A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SLCO1A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATCCAGAA
    SLCO1A2 Expression
    About this image


    SLCO1A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    SLCO1A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLCO1A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.46440
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLCO1A2: 
              Growth Factors in human mouse rat
              Drug Transporters in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO1A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLCO1A2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slco1a51 , 5 solute carrier organic anion transporter family, member more1, 5 78.11(n)1
    72.54(a)1
      6 (73.69 cM)5
    1080961  NM_001267707.11  NP_001254636.11 
     1422342275 
    chicken
    (Gallus gallus)
    Aves SLCO1A21 solute carrier organic anion transporter family, member more 65.53(n)
    58.29(a)
      418190  XM_416421.4  XP_416421.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    55(a)
    1 → many
    5(8325221-8353497)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686662 hypothetical protein MGC68666 69.57(n)    BC060021.1 


    ENSEMBL Gene Tree for SLCO1A2 (if available)
    TreeFam Gene Tree for SLCO1A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLCO1A2 gene
    SLCO2A12  SLCO4C12  SLCO1B72  ENSG000002570622  SLCO1B32  SLCO3A12  SLCO2B12  SLCO5A12  
    SLCO1B12  SLCO6A12  SLCO1C12  ENSG000002570462  SLCO4A12  
    13 SIMAP similar genes for SLCO1A2 using alignment to 14 protein entries:     SO1A2_HUMAN (see all proteins):
    SLCO1B1    SLCO1B7    SLCO1B3    SLCO1C1    SLCO3A1    LST3
    SLC21A8    SLCO5A1    SLCO2A1    SLCO2B1    DKFZp313M176    SLCO4C1
    SLCO4A1

    Find genes that share paralogs with SLCO1A2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLCO1A2 (see all 2771)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364094
    A colorectal cancer sample4--see VAR_0364092 V I mis40--------
    rs762226111,2
    C--21417153(+) TTTTAC/TTTTCT 2 -- ds50010--------
    rs1929175341,2
    --21417217(+) CAAAAC/TTAATT 2 -- ds50010--------
    rs110459151,2
    C,F,H--21417296(+) TTCTTG/ATCAAC 2 -- ds500115Minor allele frequency- A:0.16NS EA NA CSA WA 1935
    rs1852355121,2
    --21417361(+) AATTGC/TTGACT 2 -- ds50010--------
    rs1873308981,2
    --21417444(+) ACTTAA/GATAAC 2 -- ds50010--------
    rs122301131,2
    C--21417485(+) GGGAAG/AAGGAG 2 -- ds50013Minor allele frequency- A:0.24CSA WA EA 239
    rs108417771,2
    C,F,A,H--21417517(+) AGAAGA/GTATGA 2 -- ds500114Minor allele frequency- G:0.17NS EA CSA WA 1909
    rs1165834521,2
    C,F--21417618(+) CTTACA/GGGATT 2 -- ut311Minor allele frequency- G:0.04WA 118
    rs1405124121,2
    --21417650(+) AAATGA/GCTCCA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SLCO1A2 (21417534 - 21572528 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLCO1A2 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1146701CNV Insertion17803354
    nsv898890CNV Loss21882294
    nsv898894CNV Loss21882294
    nsv470274CNV Loss18288195
    nsv469161CNV Loss19166990
    nsv898886CNV Loss21882294
    nsv898893CNV Loss21882294
    dgv1390n71CNV Loss21882294
    nsv898889CNV Loss21882294
    nsv469162CNV Loss19166990

    Human Gene Mutation Database (HGMD): SLCO1A2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLCO1A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLCO1A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602883    OMIM disorders: --

    1 disease for SLCO1A2:    
    About MalaCards
    aneurysmal bone cysts


    Find genes that share disorders with SLCO1A2           About GenesLikeMe

    1 Novoseek inferred disease relationship for SLCO1A2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 19885603 (1)

    Genetic Association Database (GAD): SLCO1A2
    Human Genome Epidemiology (HuGE) Navigator: SLCO1A2 (13 documents)

    Export disorders for SLCO1A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLCO1A2 gene, integrated from 10 sources (see all 122):
    (articles sorted by number of sources associating them with SLCO1A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. (PubMed id 15632119)1, 2, 4, 9 Lee W.... Kim R.B. (J. Biol. Chem. 2005)
    2. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. (PubMed id 7557095)1, 2, 7 Kullak-Ublick G.-A.... Meier P.J. (Gastroenterology 1995)
    3. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. (PubMed id 21685912)1, 4 HAPglinger G.U....Schellenberg G.D. (Nat. Genet. 2011)
    4. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (BMC Genet. 2010)
    5. Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition. (PubMed id 20837016)1, 4 Buch S....Hampe J. (Gastroenterology 2010)
    6. The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics. (PubMed id 19890249)1, 4 Picard N....Marquet P. (Clin. Pharmacol. Ther. 2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Genome-wide association meta-analysis for total serum bilirubin levels. (PubMed id 19414484)1, 4 Johnson A.D.... Witteman J.C. (Hum. Mol. Genet. 2009)
    10. Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients. (PubMed id 18695635)1, 4 Miura M....Suzuki T. (Ther Drug Monit 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6579 HGNC: 10956 AceView: SLCO1A2 Ensembl:ENSG00000084453 euGenes: HUgn6579
    ECgene: SLCO1A2 Kegg: 6579 H-InvDB: SLCO1A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLCO1A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLCO1A2 gene:
    Search GeneIP for patents involving SLCO1A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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