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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLCO1A2 Gene

protein-coding   GIFtS: 60
GCID: GC12M021417

solute carrier organic anion transporter family, member...

(Previous names: solute carrier family 21 (organic anion transporter), member...)
(Previous symbol: SLC21A3)
 Explore 20 diseases affiliated with
SLCO1A2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLCO1A2    

Aliases
for SLCO1A2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Organic Anion Transporter Family, Member 1A21 2     Sodium-Independent Organic Anion Transporter2 3
OATP1 2 3 5     Solute Carrier Family 21 Member 32 3
SLC21A31 2 3 5     OATP-12 3
OATP-A1 2 3     Organic Anion Transporting Polypeptide A2
OATP1A21 2 3     Solute Carrier Organic Anion Transporter Family Member 1A22
Solute Carrier Family 21 (Organic Anion Transporter), Member 31 2     OATP13
Organic Anion-Transporting Polypeptide 12 3     

External Ids:    HGNC: 109561   Entrez Gene: 65792   Ensembl: ENSG000000844537   OMIM: 6028835   UniProtKB: P467213   

Export aliases for SLCO1A2 gene to outside databases

Previous GC identifers: GC12M021313 GC12M021191


Summaries
for SLCO1A2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLCO1A2:
This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its
substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the
SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. (provided
by RefSeq, Dec 2008)

UniProtKB/Swiss-Prot: SO1A2_HUMAN, P46721
Function: Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated
(taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice
component naringin

Gene Wiki entry for SLCO1A2


Genomic Views
for SLCO1A2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLCO1A2 gene promoter:
         STAT3   HNF-4alpha2   NF-kappaB   NF-kappaB1   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLCO1A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLCO1A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLCO1A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12   Ensembl cytogenetic band:  12p12.1   HGNC cytogenetic band: 12p12

SLCO1A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO1A2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M021417:  view genomic region     (about GC identifiers)

Start:
 21,417,534 bp from pter      End:
 21,572,528 bp from pter
Size:
 154,995 bases      Orientation:
 minus strand

Proteins
for SLCO1A2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SO1A2_HUMAN, P46721 (See protein sequence)
Recommended Name: Solute carrier organic anion transporter family member 1A2  
Size: 670 amino acids; 74145 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q9UGP7 Q9UL38
Alternative splicing: 2 isoforms:  P46721-1   P46721-2   

Explore the universe of human proteins at neXtProt for SLCO1A2: NX_P46721

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P46721

    • SLCO1A2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_066580.1  NP_602307.1  

    ENSEMBL proteins: 
     ENSP00000305974   ENSP00000440154   ENSP00000394854   ENSP00000438348   ENSP00000403638  
     ENSP00000416190   ENSP00000409314   ENSP00000390572   ENSP00000407462   ENSP00000401195  
     ENSP00000409691   ENSP00000390672   ENSP00000392124   ENSP00000410338   ENSP00000393973  
     ENSP00000439401   ENSP00000375088  
    Reactome Protein details: P46721
    Human Recombinant Protein Products: 
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    Uscn Proteins for SLCO1A2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--


    SLCO1A2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLCO1A2

    Protein Domains /
    Families
    for SLCO1A2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLCO1A2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR002350 Prot_inh_Kazal
     IPR004156 OA_transporter
     IPR020846 MFS_dom
     IPR011497 Kazal-type_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry P46721

    ProtoNet protein and cluster: P46721

    2 Blocks protein families:
    IPB004156 Organic anion transporter polypeptide (OATP)
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: SO1A2_HUMAN, P46721
    Similarity: Belongs to the organo anion transporter (TC 2.A.60) family
    Similarity: Contains 1 Kazal-like domain


    Function
    for SLCO1A2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SO1A2_HUMAN, P46721
    Function: Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated
    (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice
    component naringin

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLCO1A2
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SLCO1A2:
    hsa-miR-320a hsa-miR-382 hsa-miR-320b hsa-let-7g* hsa-miR-3121-3p hsa-miR-320d hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): SLCO1A2 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: SLCO1A2
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLCO1A2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0008514organic anion transmembrane transporter activity TAS9007731


    SLCO1A2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Slco1a5tm1Lex for SLCO1A2
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slco1a5):
     hematopoietic system  immune system 

    SLCO1A2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLCO1A2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transport of organic anions
    		Transport of organic anions1.00
    		Transport of vitamins, nucleosides, and related molecules0.35
    2SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50
    3Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    4Synthesis of bile acids and bile salts
    		Bile acid and bile salt metabolism0.70
    		Recycling of bile acids and salts0.11
    5Pravastatin Pathway, Pharmacokinetics
    		Methotrexate Pathway, Pharmacokinetics0.47
    		Methotrexate Pathway (Brain Cell), Pharmacokinetics0.33

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SLCO1A2
        Hepatic ABC Transporters

    5/8        Reactome Pathways for SLCO1A2 (see all 8)
        Transmembrane transport of small molecules
    SLC-mediated transmembrane transport
    Transport of vitamins, nucleosides, and related molecules
    Bile acid and bile salt metabolism
    Metabolism

    3 PharmGKB Pathways for SLCO1A2
        Methotrexate Pathway (Brain Cell), Pharmacokinetics
    Methotrexate Pathway, Pharmacokinetics
    Statin Pathway - Generalized, Pharmacokinetics

    1         Kegg Pathway  (Kegg details for SLCO1A2):
        Bile secretion


    SLCO1A2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLCO1A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for SLCO1A2 (P467213 ENSP000003059744) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A3R1O147453, ENSP000002626134I2D: score=1 STRING: ENSP00000262613
    PDZK1Q5T2W13, ENSP000003421434I2D: score=1 STRING: ENSP00000342143
    SLC9A3R2Q155993, ENSP000004080054I2D: score=1 STRING: ENSP00000408005
    ABCB11ENSP000002638174STRING: ENSP00000263817
    ABCC3ENSP000002852384STRING: ENSP00000285238
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008206bile acid metabolic process TAS--
    GO:0015711organic anion transport TAS9007731
    GO:0015721bile acid and bile salt transport TAS--
    GO:0043252sodium-independent organic anion transport TAS--
    GO:0044281small molecule metabolic process TAS--


    SLCO1A2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLCO1A2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLCO1A2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLCO1A2

    10/85 HMDB Compounds for SLCO1A2 (see all 85)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acidChenodeoxycholic acid 3-glucuronide (see all 3)58814-71-4--
    1,3,12-Trihydroxycholan-24-oic acid1,3,12-Trihydroxycholan-24-oate (see all 6)63266-91-1--
    1,3,7,12-Tetrahydroxycholan-24-oic acid1,3,7,12-Tetrahydroxycholan-24-oate (see all 10)63266-89-7--
    12-Ketodeoxycholic acid12-Dehydrodeoxycholate (see all 20)5130-29-0--
    12a-Hydroxy-3-oxocholadienic acid12a-Hydroxy-3-oxo-4,6-choladien-24-oate (see all 8)13535-96-1--
    12b-Hydroxy-5b-cholanoic acid12b-Hydroxy-5b-cholanic acid (see all 9)15173-23-6--
    1b,3a,12a-Trihydroxy-5b-cholanoic acid1,3,12-trihydroxy-(5b)-Cholan-24-oate (see all 6)80434-32-8--
    1b,3a,7a-Trihydroxy-5b-cholanoic acid1 beta,3a,7a-Trihydroxy-5b-cholanoate (see all 18)99598-04-6--
    1b-Hydroxycholic acid1b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 5)80875-94-1--
    2b,3a,7a,12a-Tetrahydroxy-5b-cholanoic acid2b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 7)60696-60-8--

    10/54 DrugBank Compounds for SLCO1A2 (see all 54)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Taurocholic Acid-- 81-24-3transportersubstrate inhibitor inducer8045503 7557095 8786566 11408557 10198348 8779894 12399219 9918568 10601278 8779893 12702494 12235261 8968376 8621133 9632674 12842829 10381771 12518026 10600646 11408531 9334206 9794920
    Conjugated EstrogensEstrogens (see all 10)438-67-5transportersubstrate inhibitor9539145 8786566 10871297 10198348 8779894 9918568 8938553 12702494 8968376 10600646 9794920
    Cholic Acid-- 81-25-4transportersubstrate inhibitor inducer8278353 8045503 7557095 10198348 9918568 8779893 11438506 12842829
    OuabainG-Strophanthin (see all 7)630-60-4transportersubstrate inhibitor8786566 11159893 10198348 8938553 9632674 10600646
    RifampinRFP (see all 3)13292-46-1transporterinhibitor12085361 11883641 10869292 10381771
    Ursodeoxycholic acid(3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid (see all 18)128-13-2transportersubstrate inhibitor inducer8045503 7557095 11438506 12842829
    DinoprostoneDinoprostone Prostaglandin E2 (see all 3)363-24-6transportersubstrate11159893 8779893 11713643
    Methyltestosterone17-methyltestosterone (see all 3)58-18-4transporterinhibitor inducer8786566 8779894 8779895
    Quinidine-- 56-54-2transporterinhibitor10421612 11883641 11408531
    TestosteroneTES (see all 9)58-22-0transporterinhibitor inducer8786566 8779894 8779895

    10/11 Novoseek chemical compound relationships for SLCO1A2 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oatp 96.4 57 11901224 (5), 8990200 (5), 11897630 (4), 12542534 (2) (see all 23)
    estrone sulfate 84.8 3 15832500 (1), 19010908 (1), 15632119 (1)
    taurocholate 82.2 8 8904218 (1), 16637898 (1), 11408557 (1), 16611857 (1) (see all 6)
    deltorphin ii 73.6 3 10871297 (1), 15632119 (1)
    bromosulfophthalein 69.7 2 8572210 (1), 15650133 (1)
    fexofenadine 69.2 6 17215845 (4), 16014768 (1)
    pravastatin 56.4 4 16611857 (1), 10601278 (1)
    digoxin 50.6 2 16611857 (1)
    probenecid 45.8 1 11408557 (1)
    prostaglandin 34.7 5 14631946 (1), 10601278 (1), 10873595 (1)

    Search CenterWatch for drugs/clinical trials and news about SLCO1A2 / SO1A2 

    Transcripts
    for SLCO1A2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLCO1A2 gene (3 alternative transcripts): 
    NM_021094.3  NM_134431.3  NM_005075.2  

    Unigene Cluster for SLCO1A2:

    Solute carrier organic anion transporter family, member 1A2
    Hs.46440  [show with all ESTs]
    Unigene Representative Sequence: NM_134431
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000307378(uc010sio.2 uc001res.3 uc010siq.2) ENST00000544020
    ENST00000458504 ENST00000544290 ENST00000480394(uc001reu.2) ENST00000463718(uc001ret.3)
    ENST00000413682 ENST00000422327 ENST00000453443 ENST00000473830 ENST00000421294
    ENST00000450590 ENST00000435179 ENST00000445053 ENST00000421287 ENST00000416627
    ENST00000430803 ENST00000452078(uc001rer.3 uc010sip.2)

    miRNA
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    hsa-miR-320a hsa-miR-382 hsa-miR-320b hsa-let-7g* hsa-miR-3121-3p hsa-miR-320d hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): SLCO1A2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLCO1A2 (see all 4)
    OriGene shRNA RFP: SLCO1A2
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLCO1A2
    Clone
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    Additional cDNA sequence: 

    AF279784.1 AK296044.1 AK316249.1 BC144256.1 U21943.1 

    14 DOTS entries:

    DT.100742569  DT.91963539  DT.95367785  DT.301466  DT.307481  DT.121183641  DT.121183647  DT.97836928 
    DT.92418196  DT.121183651  DT.121183667  DT.121183684  DT.92418195  DT.121183662 

    24/25 AceView cDNA sequences (see all 25):

    CA314457 AL589319 U21943 AF085224 NM_134431 NM_021094 AF279784 BX282641 
    NM_005075 BI668292 BG701767 BX955947 BI547522 AL705820 BC042452 AI632103 
    N80085 BG699366 N62948 BI550525 BF945519 BG204113 BG701848 AI557639 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLCO1A2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17
    SP1:                                            -                                                                             -         
    SP2:                                                                                                                                    
    SP3:                    -                                                                                                               
    SP4:                    -                                                                                                               


    ECgene alternative splicing isoforms for SLCO1A2

    Expression
    for SLCO1A2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLCO1A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATCCAGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLCO1A2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLCO1A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLCO1A2

    SOURCE GeneReport for Unigene cluster: Hs.46440
        SABiosciences Expression via Pathway-Focused PCR Arrays including SLCO1A2: 
              Growth Factors in human mouse rat
              Drug Transporters in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for SLCO1A2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLCO1A2 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLCO1A21 solute carrier organic anion transporter family, member more 65.63(n)
    58.45(a)    		   418190  XM_416421.3  XP_416421.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SLCO1A26
    --
    		 --
    		 57(a)
    42(a)
    		 1 ↔ 1
    possible ortholog
    		 5(8333119-8353497)
    5(8382878-8407873)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC686662 hypothetical protein MGC68666 69.57(n)    BC060021.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii slco1d16
    slco1f16
    (see all 6)    		 solute carrier organic anion transporter family, m...
    solute carrier organic anion transporter family, m...
    (see all 6)    		 42(a)
    42(a)
    (see all 6)    		 1 ↔ many
    possible ortholog
    (see all 6)    		 Zv9_NA995(3331-39201)
    5(62638038-62646208)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Oatp58Da6
    Oatp33Ea6
    (see all 7)    		 Organic anion transporting polypeptide 33Ea
    (see all 7)    		 20(a)
    19(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 2R(18105961-18108393)
    2L(12441401-12445924)
    worm
    (Caenorhabditis elegans)    		 Secernentea F21G4.16
    F47E1.26
    (see all 4)    		 --
    		 22(a)
    20(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 X(9889257-9892270)
    X(9057595-9061806)


    ENSEMBL Gene Tree for SLCO1A2 (if available)
    TreeFam Gene Tree for SLCO1A2 (if available) 

    Paralogs
    for SLCO1A2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLCO1A2 gene
    SLCO2A12  SLCO4C12  SLCO1B72  ENSG000002570622  SLCO3A12  SLCO1B32  SLCO5A12  SLCO2B12  
    SLCO6A12  SLCO1B12  ENSG000002570462  SLCO4A12  SLCO1C12  
    13 SIMAP similar genes for SLCO1A2 using alignment to 14 protein entries:     SO1A2_HUMAN (see all proteins):
    SLCO1B1    SLCO1B3    SLCO1B7    SLCO1C1    SLCO3A1    SLC21A8
    LST3    SLCO5A1    SLCO2A1    SLCO2B1    DKFZp313M176    SLCO4C1
    SLCO4A1

    SLCO1A2 for paralogs           About GeneDecksing



    Genomic Variants
    for SLCO1A2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2337 NCBI SNPs in SLCO1A2 are shown (see all 2337)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs762226111,2
    		--21417153(+) TTTTAC/TTTTCT 2 -- ds50010--------
    rs1929175341,2
    		--21417217(+) CAAAAC/TTAATT 2 -- ds50010--------
    rs110459151,2
    		C,F,H,--21417296(+) TTCTTG/ATCAAC 2 -- ds500115Minor allele frequency- A:0.16NS EA NA CSA WA 1935
    rs1852355121,2
    		--21417361(+) AATTGC/TTGACT 2 -- ds50010--------
    rs1873308981,2
    		--21417444(+) ACTTAA/GATAAC 2 -- ds50010--------
    rs122301131,2
    		--21417485(+) GGGAAG/AAGGAG 2 -- ds50013Minor allele frequency- A:0.24CSA WA EA 239
    rs108417771,2
    		C,F,A,H,--21417517(+) AGAAGA/GTATGA 2 -- ds500114Minor allele frequency- G:0.17NS EA CSA WA 1909
    rs1165834521,2
    		C,F,--21417618(+) CTTACA/GGGATT 2 -- ut311Minor allele frequency- G:0.04WA 118
    rs1405124121,2
    		--21417650(+) AAATGA/GCTCCA 2 -- ut310--------
    rs759679891,2
    		F,--21417704(+) TCTTAA/GGGGTA 2 -- ut311Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for SLCO1A2 (21417534 - 21572528 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for SLCO1A2
         3 CNVs: 49027 49028 49026
    Human Gene Mutation Database (HGMD): SLCO1A2

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for SLCO1A2

    Disorders / Diseases
    for SLCO1A2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLCO1A2 for disorders           About GeneDecksing

    OMIM gene information: 602883    OMIM disorders: --

    20 diseases for SLCO1A2:    About MalaCards
    supranuclear palsy    progressive supranuclear palsy    aneurysmal bone cysts    intrahepatic cholestasis
    intrahepatic cholestasis of pregnancy    biliary atresia    cholestasis    chronic myeloid leukemia
    myeloid leukemia    tauopathy    aldosteronism    liver disease
    choroiditis    leukemia    osteosarcoma    breast cancer
    cerebritis    cholesterol    thyroiditis    hepatitis

    1 Novoseek disease relationship for SLCO1A2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 19885603 (1)

    Genetic Association Database (GAD): SLCO1A2
    Human Genome Epidemiology (HuGE) Navigator: SLCO1A2 (13 documents)

    Export disorders for SLCO1A2 gene to outside databases

    Publications
    for SLCO1A2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLCO1A2 gene, integrated from 9 sources (see all 116):
    (articles sorted by number of sources associating them with SLCO1A2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. (PubMed id 15632119)1, 2, 4, 9 Lee W.... Kim R.B. (2005)
    2. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. (PubMed id 7557095)1, 2, 7 Kullak-Ublick G.-A.... Meier P.J. (1995)
    3. Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes. (PubMed id 11238933)1, 2 Speek M. (2001)
    4. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. (PubMed id 10779507)1, 2 Koenig J.... Keppler D. (2000)
    5. Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain. (PubMed id 9539145)1, 7 Kullak-Ublick G.A....Paumgartner G. (1998)
    6. Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12p12 by fluorescence in situ hybridization. (PubMed id 9007731)1, 3 Kullak-Ublick G.A....Paumgartner G. (1996)
    7. Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells. (PubMed id 15832500)1, 9 Su Y....Sinko P.J. (2004)
    8. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (PubMed id 10873595)1, 9 Tamai I.... Tsuji A. (2000)
    9. Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer. (PubMed id 19010908)1, 9 Meyer zu Schwabedissen H.E....Kim R.B. (2008)
    10. Comparison of 'type I' and 'type II' organic cation transport by organic cation transporters and organic anion-transporting polypeptides. (PubMed id 11408531)7, 9 van Montfoort J.E.... Meier P.J. (2001)

    External Searches for SLCO1A2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing SLCO1A2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6579 HGNC: 10956 AceView: SLCO1A2 Ensembl:ENSG00000084453 euGenes: HUgn6579
    ECgene: SLCO1A2 Kegg: 6579 H-InvDB: SLCO1A2

    Other Databases showing SLCO1A2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLCO1A2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLCO1A2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLCO1A2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLCO1A2 gene:
    Search GeneIP for patents involving SLCO1A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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