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Aliases for SLCO1A2 Gene

Aliases for SLCO1A2 Gene

  • Solute Carrier Organic Anion Transporter Family Member 1A2 2 3 5
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 3 2 3
  • Solute Carrier Organic Anion Transporter Family, Member 1A2 2 3
  • Sodium-Independent Organic Anion Transporter 3 4
  • Organic Anion-Transporting Polypeptide 1 3 4
  • Solute Carrier Family 21 Member 3 3 4
  • SLC21A3 3 4
  • OATP1A2 3 4
  • OATP-1 3 4
  • OATP-A 3 4
  • OATP 3 4
  • Organic Anion Transporting Polypeptide A 3
  • OATP1 4

External Ids for SLCO1A2 Gene

Previous HGNC Symbols for SLCO1A2 Gene

  • SLC21A3

Previous GeneCards Identifiers for SLCO1A2 Gene

  • GC12M021313
  • GC12M021417

Summaries for SLCO1A2 Gene

Entrez Gene Summary for SLCO1A2 Gene

  • This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]

GeneCards Summary for SLCO1A2 Gene

SLCO1A2 (Solute Carrier Organic Anion Transporter Family Member 1A2) is a Protein Coding gene. Diseases associated with SLCO1A2 include aneurysmal bone cysts and intrahepatic cholestasis. Among its related pathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and organic anion transmembrane transporter activity. An important paralog of this gene is SLCO1B7.

UniProtKB/Swiss-Prot for SLCO1A2 Gene

  • Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.

Gene Wiki entry for SLCO1A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO1A2 Gene

Genomics for SLCO1A2 Gene

Regulatory Elements for SLCO1A2 Gene

Promoters for SLCO1A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLCO1A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLCO1A2 Gene

Chromosome:
12
Start:
21,264,600 bp from pter
End:
21,419,594 bp from pter
Size:
154,995 bases
Orientation:
Minus strand

Genomic View for SLCO1A2 Gene

Genes around SLCO1A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO1A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO1A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO1A2 Gene

Proteins for SLCO1A2 Gene

  • Protein details for SLCO1A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46721-SO1A2_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 1A2
    Protein Accession:
    P46721
    Secondary Accessions:
    • Q9UGP7
    • Q9UL38

    Protein attributes for SLCO1A2 Gene

    Size:
    670 amino acids
    Molecular mass:
    74145 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLCO1A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLCO1A2 Gene

Proteomics data for SLCO1A2 Gene at MOPED

Post-translational modifications for SLCO1A2 Gene

  • Glycosylation at Asn 124, Asn 135, Asn 412, and Asn 419
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SLCO1A2 Gene

Domains & Families for SLCO1A2 Gene

Gene Families for SLCO1A2 Gene

Graphical View of Domain Structure for InterPro Entry

P46721

UniProtKB/Swiss-Prot:

SO1A2_HUMAN :
  • Contains 1 Kazal-like domain.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
Domain:
  • Contains 1 Kazal-like domain.
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO1A2: view

Function for SLCO1A2 Gene

Molecular function for SLCO1A2 Gene

UniProtKB/Swiss-Prot Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.

Gene Ontology (GO) - Molecular Function for SLCO1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008514 organic anion transmembrane transporter activity TAS 9007731
GO:0015125 bile acid transmembrane transporter activity IBA,TAS --
genes like me logo Genes that share ontologies with SLCO1A2: view
genes like me logo Genes that share phenotypes with SLCO1A2: view

Animal Models for SLCO1A2 Gene

MGI Knock Outs for SLCO1A2:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLCO1A2 Gene

Localization for SLCO1A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO1A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLCO1A2 Gene COMPARTMENTS Subcellular localization image for SLCO1A2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLCO1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLCO1A2: view

Pathways & Interactions for SLCO1A2 Gene

genes like me logo Genes that share pathways with SLCO1A2: view

Gene Ontology (GO) - Biological Process for SLCO1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008206 bile acid metabolic process IBA,TAS --
GO:0043252 sodium-independent organic anion transport TAS --
GO:0055085 transmembrane transport TAS --
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
genes like me logo Genes that share ontologies with SLCO1A2: view

No data available for SIGNOR curated interactions for SLCO1A2 Gene

Drugs & Compounds for SLCO1A2 Gene

(72) Drugs for SLCO1A2 Gene - From: IUPHAR, DGIdb, DrugBank, HMDB, Novoseek, FDA Approved Drugs, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rifampicin Approved Pharma Agonist, binder, Target, Transporter, inhibitor Pregnane X receptor agonist; antibiotic 303
Probenecid Approved Pharma Inhibition, Inhibitor, Transporter, inhibitor 27
Bumetanide Approved Pharma Agonist, Transporter, substrate NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) symporter inhibitor 15
cholic acid Approved Pharma Full agonist, Agonist, Transporter, substrate, inhibitor, inducer 0
deoxycholic acid Approved Pharma Antagonist, Transporter, substrate, inhibitor 39

(86) Additional Compounds for SLCO1A2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
  • Chenodeoxycholic acid-3-b-D-glucuronide
  • Chenodeoxycholic acid-3-beta-delta-glucuronide
58814-71-4
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxy-5b-Cholanoate
  • 1,3,12-Trihydroxy-5b-Cholanoic acid
  • 1,3,12-Trihydroxy-Cholan-24-oate
  • 1,3,12-Trihydroxy-Cholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-oate
63266-91-1
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oate
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-oate
  • 1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholanoate
63266-89-7
12a-Hydroxy-3-oxocholadienic acid
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oate
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oic acid
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienate
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienic acid
  • 12a-Hydroxy-3-oxochola-4,6-dienate
13535-96-1
12b-Hydroxy-5b-cholanoic acid
  • 12-Hydroxy-(5b,12b)-Cholan-24-oate
  • 12-Hydroxy-(5b,12b)-Cholan-24-oic acid
  • 12b-Hydroxy-5b-Cholan-24-oate
  • 12b-Hydroxy-5b-Cholan-24-oic acid
  • 12b-Hydroxy-5b-cholanic acid
15173-23-6
genes like me logo Genes that share compounds with SLCO1A2: view

Transcripts for SLCO1A2 Gene

Unigene Clusters for SLCO1A2 Gene

Solute carrier organic anion transporter family, member 1A2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO1A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17
SP1: - -
SP2:
SP3: -
SP4: -

Relevant External Links for SLCO1A2 Gene

GeneLoc Exon Structure for
SLCO1A2
ECgene alternative splicing isoforms for
SLCO1A2

Expression for SLCO1A2 Gene

mRNA expression in normal human tissues for SLCO1A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO1A2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.9), Brain - Substantia nigra (x7.3), Brain - Hippocampus (x6.8), Brain - Amygdala (x6.3), Brain - Putamen (basal ganglia) (x5.0), and Brain - Hypothalamus (x4.6).

SOURCE GeneReport for Unigene cluster for SLCO1A2 Gene Hs.46440

genes like me logo Genes that share expression patterns with SLCO1A2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLCO1A2 Gene

Orthologs for SLCO1A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLCO1A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLCO1A2 35
  • 87.64 (n)
  • 83.03 (a)
SLCO1A2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLCO1A2 35
  • 89.65 (n)
  • 86.72 (a)
OATPA 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slco1a5 35
  • 78.11 (n)
  • 72.54 (a)
Slco1a5 16
Gm5724 36
  • 66 (a)
OneToMany
Gm6614 36
  • 67 (a)
OneToMany
Slco1a1 36
  • 69 (a)
OneToMany
Slco1a4 36
  • 73 (a)
OneToMany
Slco1a5 36
  • 73 (a)
OneToMany
Slco1a6 36
  • 66 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SLCO1A2 35
  • 99.3 (n)
  • 99.25 (a)
SLCO1A2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slco1a5 35
  • 77.66 (n)
  • 72.39 (a)
oppossum
(Monodelphis domestica)
Mammalia SLCO1A2 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLCO1A2 35
  • 65.53 (n)
  • 58.29 (a)
-- 36
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC68666 35
Species with no ortholog for SLCO1A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLCO1A2 Gene

ENSEMBL:
Gene Tree for SLCO1A2 (if available)
TreeFam:
Gene Tree for SLCO1A2 (if available)

Paralogs for SLCO1A2 Gene

genes like me logo Genes that share paralogs with SLCO1A2: view

Variants for SLCO1A2 Gene

Sequence variations from dbSNP and Humsavar for SLCO1A2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11568567 - 21,306,942(-) CCTCA(A/T)ACAGT reference, missense
rs45502302 - 21,306,920(-) GGAAA(A/T)TGGAA reference, missense
rs11568563 - 21,304,500(-) GGTGA(A/C)ACTCC reference, missense
rs45628437 - 21,297,416(-) ATGCA(A/G)TCTTT reference, missense
rs11568557 - 21,269,558(-) GAAAA(C/G)TAAAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLCO1A2 Gene

Variant ID Type Subtype PubMed ID
nsv515735 CNV Gain+Loss 19592680
nsv898883 CNV Loss 21882294
dgv1390n71 CNV Loss 21882294
nsv898886 CNV Loss 21882294
nsv898889 CNV Loss 21882294
nsv898890 CNV Loss 21882294
dgv1391n71 CNV Loss 21882294
nsv898893 CNV Loss 21882294
esv1146701 CNV Insertion 17803354
nsv469161 CNV Loss 19166990
esv2750499 CNV Gain 17666407
nsv519603 CNV Gain+Loss 19592680
nsv470274 CNV Loss 18288195
nsv469162 CNV Loss 19166990
nsv898894 CNV Loss 21882294

Variation tolerance for SLCO1A2 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.36; 70.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLCO1A2 Gene

HapMap Linkage Disequilibrium report
SLCO1A2
Human Gene Mutation Database (HGMD)
SLCO1A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO1A2 Gene

Disorders for SLCO1A2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLCO1A2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
aneurysmal bone cysts
  • bone cysts aneurysmal
intrahepatic cholestasis
  • intrahepatic cholestasis of pregnancy
bile duct disease
  • bile duct disorder nos
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLCO1A2

Genetic Association Database (GAD)
SLCO1A2
Human Genome Epidemiology (HuGE) Navigator
SLCO1A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLCO1A2
genes like me logo Genes that share disorders with SLCO1A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLCO1A2 Gene

Publications for SLCO1A2 Gene

  1. Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. (PMID: 15632119) Lee W. … Kim R.B. (J. Biol. Chem. 2005) 3 4 23 48 67
  2. Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. (PMID: 11316767) Fujiwara K. … Abe T. (Endocrinology 2001) 23 25 26
  3. Comparison of 'type I' and 'type II' organic cation transport by organic cation transporters and organic anion-transporting polypeptides. (PMID: 11408531) van Montfoort J.E. … Meier P.J. (J. Pharmacol. Exp. Ther. 2001) 23 25 26
  4. Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier. (PMID: 11408557) Sugiyama D. … Sugiyama Y. (J. Pharmacol. Exp. Ther. 2001) 23 25 26
  5. Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier. (PMID: 10871297) Gao B. … Meier P.J. (J. Pharmacol. Exp. Ther. 2000) 23 25 26

Products for SLCO1A2 Gene

Sources for SLCO1A2 Gene

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