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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC9C2 Gene

protein-coding   GIFtS: 43
GCID: GC01M173470

Solute Carrier Family 9, Member C2 (Putative)

(Previous names: solute carrier family 9, isoform 11, solute carrier family...)
(Previous symbol: SLC9A11)
Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 9, Member C2 (Putative)1 2     Solute Carrier Family 9, Isoform 111
SLC9A111 2 3     Solute Carrier Family 9, Member C21
Solute Carrier Family 9, Member 111 2     RP3-436N22.22
Solute Carrier Family 9 Member C22 3     Sodium/Hydrogen Exchanger 112
NHE-112 3     Solute Carrier Family 92
Na(+)/H(+) Exchanger 112 3     Solute Carrier Family 9 Member 113

External Ids:    HGNC: 286641   Entrez Gene: 2845252   Ensembl: ENSG000001627537   UniProtKB: Q5TAH23   

Export aliases for SLC9C2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC9C2 Gene: 
SLC9C2 (solute carrier family 9, member C2 (putative)) is a protein-coding gene. Diseases associated with SLC9C2 include pneumonia, and among its related super-pathways are Stimuli-sensing channels and SLC-mediated transmembrane transport. GO annotations related to this gene include ion channel activity and solute:hydrogen antiporter activity. An important paralog of this gene is SLC9C1.

UniProtKB/Swiss-Prot: SL9C2_HUMAN, Q5TAH2
Function: Involved in pH regulation (By similarity)

Gene Wiki entry for SLC9C2 (SLC9A11) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SLC9C2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC9C2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC9C2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC9C2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.1   Ensembl cytogenetic band:  1q25.1   HGNC cytogenetic band: 1q25.1

SLC9C2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC9C2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M173470:  view genomic region     (about GC identifiers)

Start:
173,469,603 bp from pter      End:
173,572,233 bp from pter
Size:
102,631 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SL9C2_HUMAN, Q5TAH2 (See protein sequence)
Recommended Name: Sodium/hydrogen exchanger 11  
Size: 1124 amino acids; 129053 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q86UF3

Explore the universe of human proteins at neXtProt for SLC9C2: NX_Q5TAH2

Explore proteomics data for SLC9C2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5TAH2

  • SLC9C2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC9C2 Protein Expression
    REFSEQ proteins: NP_848622.2  
    ENSEMBL proteins: 
     ENSP00000356687   ENSP00000445437  
    Reactome Protein details: Q5TAH2
    Human Recombinant Protein Products for SLC9C2: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    SLC9C2 for ontologies           About GeneDecksing



    SLC9C2 Antibody Products: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Sodium/hydrogen exchanger 11 
    SLC9 family of sodium/hydrogen exchangers

    5/7 InterPro protein domains (see all 7):
     IPR000595 cNMP-bd_dom
     IPR018422 Cation/H_exchanger_CPA1
     IPR027359 K_channel_four-helix_dom
     IPR006153 Cation/H_exchanger
     IPR018490 cNMP-bd-like

    Graphical View of Domain Structure for InterPro Entry Q5TAH2

    ProtoNet protein and cluster: Q5TAH2

    1 Blocks protein domain: IPB000595 Cyclic nucleotide-binding domain

    UniProtKB/Swiss-Prot: SL9C2_HUMAN, Q5TAH2
    Domain: Contains an ion transport-like region is related to the membrane segments of voltage-gated ion channels
    (By similarity)
    Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
    Similarity: Contains 1 cyclic nucleotide-binding domain


    SLC9C2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SL9C2_HUMAN, Q5TAH2
    Function: Involved in pH regulation (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015299solute:hydrogen antiporter activity IEA--
         
    SLC9C2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC9C2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC9C2 
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    miRNA
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9C2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC9C2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.49
    Stimuli-sensing channels0.49
    2SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for SLC9C2
        Transmembrane transport of small molecules
    Stimuli-sensing channels
    Ion channel transport



    SLC9C2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC9C2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLC9C2 (ENSP000003566874) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000228299ENSP000003978674STRING: ENSP00000397867
    NEXNENSP000003339384STRING: ENSP00000333938
    --ENSP000004136774STRING: ENSP00000413677
    --ENSP000003876684STRING: ENSP00000387668
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport ----
    GO:0006814sodium ion transport IEA--
    GO:0055085transmembrane transport ----

    SLC9C2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC9C2 (SL9C2)

    Search CenterWatch for drugs/clinical trials and news about SLC9C2 / SL9C2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC9C2 gene: 
    NM_178527.3  

    Unigene Cluster for SLC9C2:

    Solute carrier family 9, member C2 (putative)
    Hs.494981  [show with all ESTs]
    Unigene Representative Sequence: AL832631
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367714(uc001giz.2 uc010pmq.1) ENST00000466087(uc009wwe.2)
    ENST00000497689 ENST00000479367 ENST00000476568 ENST00000536496
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SLC9C2
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC9C2

    Additional mRNA sequence: 

    AK128104.1 AK302731.1 AL832631.2 BC042592.1 BX648119.1 

    2 DOTS entries:

    DT.95101497  DT.99986389 

    18 AceView cDNA sequences:

    AA724256 AA621275 NM_178527 BX648119 AA634531 AA926665 AI027619 AA954546 
    AA398085 AK128104 BC042592 BM979514 BU853927 BG482704 BG773317 AA399386 
    CA440089 BQ428705 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC9C2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                                      -                                         -                                                                           
    SP2:                                                                                            -                                                               
    SP3:              -           -                                                                                                                                 
    SP4:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          


    ECgene alternative splicing isoforms for SLC9C2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC9C2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTTGTTA
    SLC9C2 Expression
    About this image


    See SLC9C2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC9C2

    SOURCE GeneReport for Unigene cluster: Hs.494981
        SABiosciences Custom PCR Arrays for SLC9C2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9C2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SLC9C2 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    rat
    (Rattus norvegicus)
    Mammalia Slc9c21 solute carrier family 9, member C2 (putative) 78.19(n)
    69.89(a)
      364029  XM_344165.3  XP_344166.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    32(a)
    1 → many
    1(75660752-75769510)


    ENSEMBL Gene Tree for SLC9C2 (if available)
    TreeFam Gene Tree for SLC9C2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC9C2 gene
    SLC9C12  
    2 SIMAP similar genes for SLC9C2 using alignment to 2 protein entries:     SL9C2_HUMAN (see all proteins):
    SLC9C1    SCN5A

    SLC9C2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1956 SNPs in SLC9C2 are shown (see all 1956)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs75484151,2
    C--173469328(+) atcatA/C/Taagaa 1 -- ds50010--------
    rs1461207861,2
    --173469384(+) CTATGA/GAGTAG 1 -- ds50010--------
    rs1836887001,2
    --173469467(+) CTTGGA/GCGAGA 1 -- ds50010--------
    rs1401026871,2
    --173469620(+) AAACTC/TAACTT 1 -- ut310--------
    rs1868600581,2
    --173469735(+) TACTGA/GAAGTT 1 -- ut310--------
    rs1917447661,2
    --173469838(+) AATTAC/TAACAA 1 -- ut310--------
    rs412645661,2
    F--173469862(+) AATTAC/TAGGTT 1 -- ut310--------
    rs1147083111,2
    C,F--173469885(+) GAGTAA/GCATAT 1 -- ut311Minor allele frequency- G:0.10WA 118
    rs1866084421,2
    --173470054(+) TTTACA/GGAAGT 1 -- ut310--------
    rs120654261,2
    C,F,H--173470105(+) TCAGTA/GGCTTC 1 -- ut31 ese322Minor allele frequency- G:0.31NS EA NA WA CSA 2348

    HapMap Linkage Disequilibrium report for SLC9C2 (173469603 - 173572233 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC9C2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC9C2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC9C2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for SLC9C2:    About MalaCards
    pneumonia    


    SLC9C2 for disorders           About GeneDecksing


    Export disorders for SLC9C2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC9C2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SLC9C2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284525 HGNC: 28664 AceView: MGC43026 Ensembl:ENSG00000162753 euGenes: HUgn284525
    ECgene: SLC9C2 H-InvDB: SLC9C2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC9C2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC9C2 gene:
    Search GeneIP for patents involving SLC9C2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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