SLC9C2 Gene
protein-coding GIFtS: 43
GCID: GC01M173470
|
|
solute carrier family 9, member C2 (putative)(Previous names: solute carrier family 9, isoform 11, solute carrier family...)
(Previous symbol: SLC9A11)
| |
Aliases
for SLC9C2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 9, Member C2 (Putative)1 2 | | MGC430261 | | SLC9A111 2 3 | | Solute Carrier Family 9, Isoform 111 | | Solute Carrier Family 9, Member 111 2 | | RP3-436N22.22 | | Solute Carrier Family 9 Member C22 3 | | Sodium/Hydrogen Exchanger 112 | | NHE-112 3 | | Solute Carrier Family 92 | | Na(+)/H(+) Exchanger 112 3 | | Solute Carrier Family 9 Member 113 |
Export aliases for SLC9C2 gene to outside databases |
Summaries
for SLC9C2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SL9C2_HUMAN, Q5TAH2Function: Involved in pH regulation (By similarity)
Gene Wiki entry for SLC9C2 (SLC9A11)
|
Genomic Views
for SLC9C2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SLC9C2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC9C2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC9C2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q25.1 Ensembl cytogenetic band: 1q25.1 HGNC cytogenetic band: 1q25.1SLC9C2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M173470: view genomic region
(about GC identifiers)
Start:
|
173,469,603 bp from pter |
End:
|
173,572,233 bp from pter |
Size:
|
102,631 bases |
Orientation:
|
minus strand |
|
Proteins
for SLC9C2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SL9C2_HUMAN, Q5TAH2 (See
protein sequence)Recommended Name: Sodium/hydrogen exchanger 11 Size: 1124 amino acids; 129053 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q86UF3Explore the universe of human proteins at neXtProt for SLC9C2: NX_Q5TAH2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5TAH2
SLC9C2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_848622.2
ENSEMBL proteins: ENSP00000356687 ENSP00000445437 Reactome Protein details: Q5TAH2
Human Recombinant Protein Products for SLC9C2:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SLC9C2 for ontologies About GeneDecksing
SLC9C2 Antibody Products:
Assay Products for SLC9C2: |
Protein
Domains /
Families
for SLC9C2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC9C2 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q5TAH2ProtoNet protein and cluster: Q5TAH2 1 Blocks protein family: IPB000595 Cyclic nucleotide-binding domain
UniProtKB/Swiss-Prot: SL9C2_HUMAN, Q5TAH2Domain: Contains an ion transport-like region is related to the membrane segments of voltage-gated ion channels (Bysimilarity)Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) familySimilarity: Contains 1 cyclic nucleotide-binding domain |
Function
for SLC9C2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SL9C2_HUMAN, Q5TAH2Function: Involved in pH regulation (By similarity) Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005216 | ion channel activity |
IEA | -- | | GO:0015299 | solute:hydrogen antiporter activity |
IEA | -- |
SLC9C2 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9C2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9C2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for SLC9C2 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC9C2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9C2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9C2 |
|
Pathways & Interactions
for SLC9C2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ion channel transport | | | 2 | SLC-mediated transmembrane transport | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for SLC9C2
SLC9C2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC9C2
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for SLC9C2 (ENSP000003566874) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006814 | sodium ion transport |
IEA | -- |
SLC9C2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC9C2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC9C2
Search CenterWatch for drugs/clinical trials and news about SLC9C2 / SL9C2
|
Transcripts
for SLC9C2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC9C2 gene: NM_178527.3 Unigene Cluster for SLC9C2: Solute carrier family 9, member C2 (putative) Hs.494981 [show with all ESTs]Unigene Representative Sequence: AL8326316 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367714(uc001giz.2 uc010pmq.1) ENST00000466087(uc009wwe.2)
ENST00000497689 ENST00000479367 ENST00000476568 ENST00000536496
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9C2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9C2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SLC9C2 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC9C2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9C2 |
Additional cDNA sequence: AK128104.1 AK302731.1 AL832631.2 BC042592.1 BX648119.1 2 DOTS entries: DT.95101497 DT.99986389 18 AceView cDNA sequences: AA621275 AA634531 BX648119 BM979514 NM_178527 BC042592 AA398085 AA724256 AA926665 AI027619 AA954546 AK128104 BU853927 CA440089 AA399386 BG482704 BG773317 BQ428705
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC9C2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 |
|---|
|
| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SLC9C2
|
Expression
for SLC9C2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC9C2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATTTGTTA
About this image
See SLC9C2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC9C2
SOURCE GeneReport for Unigene cluster: Hs.494981
SABiosciences Custom PCR Arrays for SLC9C2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC9C2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SLC9C2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC9C2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC9C2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9C2 |
Orthologs
for SLC9C2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for SLC9C2 gene from 3/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATNHX76ATNHX86 |
sodium/hydrogen exchanger 8 |
8(a)12(a) |
many ↔ manymany ↔ many |
2(457010-463326) 1(5031950-5036477) |
rice
(Oryza sativa) |
Liliopsida |
-- |
sodium/hydrogen exchanger 7, putative, expressed |
9(a) |
1 → many |
12(27460759-27475209) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
yjcE6 |
predicted cation/proton antiporter |
9(a) |
1 → many |
Chromosome(4278003-4279652) |
ENSEMBL Gene Tree for SLC9C2 (if available)
TreeFam Gene Tree for SLC9C2 (if available) |
Paralogs
for SLC9C2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC9C2 gene
- SLC9C12
2 SIMAP similar genes for SLC9C2 using alignment to 2 protein entries: SL9C2_HUMAN (see all proteins):SLC9C1 SCN5A
SLC9C2 for paralogs About GeneDecksing
|
Genomic Variants
for SLC9C2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC9C2 (173469603 - 173572233 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC9C2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC9C2 |
|
Disorders
/ Diseases
for SLC9C2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC9C2 for disorders About GeneDecksing
1  disease for SLC9C2: About MalaCardsmalaria
Export disorders for SLC9C2 gene to outside databases
|
Publications
for SLC9C2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC9C2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC9C2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SLC9C2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC9C2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC9C2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC9C2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC9C2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC9C2 gene:
Search GeneIP for patents involving SLC9C2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC9C2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC9C2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC9C2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC9C2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC9C2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC9C2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC9C2 |
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| |  |  |  |  | | | | |
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 | | | SLC9C2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9C2 |
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