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Aliases for SLC9C2 Gene

Aliases for SLC9C2 Gene

  • Solute Carrier Family 9, Member C2 (Putative) 2 3
  • Solute Carrier Family 9, Member 11 2 3
  • Solute Carrier Family 9 Member C2 3 4
  • Na(+)/H(+) Exchanger 11 3 4
  • SLC9A11 3 4
  • NHE-11 3 4
  • Solute Carrier Family 9, Isoform 11 2
  • Solute Carrier Family 9, Member C2 2
  • Solute Carrier Family 9 Member 11 4
  • Sodium/Hydrogen Exchanger 11 3
  • Solute Carrier Family 9 3

External Ids for SLC9C2 Gene

Previous Symbols for SLC9C2 Gene

  • SLC9A11

Summaries for SLC9C2 Gene

GeneCards Summary for SLC9C2 Gene

SLC9C2 (Solute Carrier Family 9, Member C2 (Putative)) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include solute:proton antiporter activity. An important paralog of this gene is SLC9C1.

UniProtKB/Swiss-Prot for SLC9C2 Gene

  • Involved in pH regulation.

Gene Wiki entry for SLC9C2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC9C2 Gene

Genomics for SLC9C2 Gene

Genomic Location for SLC9C2 Gene

173,500,464 bp from pter
173,603,094 bp from pter
102,631 bases
Minus strand

Genomic View for SLC9C2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC9C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC9C2 Gene

No data available for Regulatory Elements for SLC9C2 Gene

Proteins for SLC9C2 Gene

  • Protein details for SLC9C2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/hydrogen exchanger 11
    Protein Accession:
    Secondary Accessions:
    • Q86UF3

    Protein attributes for SLC9C2 Gene

    1124 amino acids
    Molecular mass:
    129053 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC9C2 Gene

Proteomics data for SLC9C2 Gene at MOPED

Post-translational modifications for SLC9C2 Gene

  • Glycosylation at Asn447 and Asn473

Other Protein References for SLC9C2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC9C2 Gene

Domains for SLC9C2 Gene

Gene Families for SLC9C2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains an ion transport-like region is related to the membrane segments of voltage-gated ion channels.:
    • Q5TAH2
  • Contains 1 cyclic nucleotide-binding domain.:
    • Q5TAH2
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.:
    • Q5TAH2
genes like me logo Genes that share domains with SLC9C2: view

No data available for Suggested Antigen Peptide Sequences for SLC9C2 Gene

Function for SLC9C2 Gene

Molecular function for SLC9C2 Gene

UniProtKB/Swiss-Prot Function: Involved in pH regulation.

Gene Ontology (GO) - Molecular Function for SLC9C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015299 solute:proton antiporter activity IEA --
genes like me logo Genes that share ontologies with SLC9C2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC9C2 Gene

Localization for SLC9C2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC9C2 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SLC9C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC9C2: view

No data available for Subcellular locations from COMPARTMENTS for SLC9C2 Gene

Pathways for SLC9C2 Gene

genes like me logo Genes that share pathways with SLC9C2: view

Pathways by source for SLC9C2 Gene

Interacting Proteins for SLC9C2 Gene

Gene Ontology (GO) - Biological Process for SLC9C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport --
GO:0006814 sodium ion transport IEA --
GO:0055085 transmembrane transport --
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC9C2: view

Transcripts for SLC9C2 Gene

Unigene Clusters for SLC9C2 Gene

Solute carrier family 9, member C2 (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC9C2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - -
SP2: -
SP3: - -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30

Relevant External Links for SLC9C2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC9C2 Gene

mRNA expression in normal human tissues for SLC9C2 Gene

mRNA differential expression in normal tissues according to GTEx for SLC9C2 Gene

This gene is overexpressed in Testis (20.6) and Brain - Caudate (basal ganglia) (4.2).

SOURCE GeneReport for Unigene cluster for SLC9C2 Gene Hs.494981

genes like me logo Genes that share expressions with SLC9C2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for SLC9C2 Gene

Orthologs for SLC9C2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC9C2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC9C2 35
  • 99.56 (n)
  • 99.2 (a)
SLC9C2 36
  • 99 (a)
(Bos Taurus)
Mammalia SLC9C2 35
  • 83.54 (n)
  • 73.57 (a)
SLC9C2 36
  • 73 (a)
(Canis familiaris)
Mammalia SLC9C2 35
  • 83.41 (n)
  • 71.31 (a)
SLC9C2 36
  • 76 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
-- 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia SLC9C2 36
  • 52 (a)
(Rattus norvegicus)
Mammalia Slc9c2 35
  • 76.29 (n)
  • 67.39 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
-- 36
  • 22 (a)
Species with no ortholog for SLC9C2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC9C2 Gene

Gene Tree for SLC9C2 (if available)
Gene Tree for SLC9C2 (if available)

Paralogs for SLC9C2 Gene

Paralogs for SLC9C2 Gene

Selected SIMAP similar genes for SLC9C2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC9C2: view

Variants for SLC9C2 Gene

Sequence variations from dbSNP and Humsavar for SLC9C2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs182477 -- 173,593,279(+) cactt(A/T)gggag intron-variant
rs186203 -- 173,593,269(+) gtaat(C/T)ccagc intron-variant
rs301694 -- 173,602,293(-) ATACC(A/C)ACAGA intron-variant
rs301695 -- 173,539,753(-) TTCAG(A/T)CTCCT intron-variant
rs301696 -- 173,539,646(-) GCTAC(A/G)CTCAT intron-variant

Relevant External Links for SLC9C2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC9C2 Gene

Disorders for SLC9C2 Gene

No disorders were found for SLC9C2 Gene.

No data available for UniProtKB/Swiss-Prot for SLC9C2 Gene

Publications for SLC9C2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for SLC9C2 Gene

Sources for SLC9C2 Gene

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