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Aliases for SLC9C1 Gene

Aliases for SLC9C1 Gene

  • Solute Carrier Family 9, Subfamily C (Na+-Transporting Carboxylic Acid Decarboxylase), Member 1 2 3
  • SLC9A10 3 4 6
  • Sperm-Specific Na(+)/H(+) Exchanger 3 4
  • Solute Carrier Family 9, Member 10 2 3
  • Solute Carrier Family 9 Member C1 3 4
  • Na(+)/H(+) Exchanger 10 3 4
  • Sperm-NHE 2 3
  • NHE-10 3 4
  • SNHE 3 4
  • Sperm-Specific Sodium Proton Exchanger 3
  • Solute Carrier Family 9, Isoform 10 2
  • Solute Carrier Family 10 Member 10 3
  • Solute Carrier Family 9 Member 10 4
  • Sodium/Hydrogen Exchanger 10 3
  • Solute Carrier Family 9 3
  • NHE 3

External Ids for SLC9C1 Gene

Previous HGNC Symbols for SLC9C1 Gene

  • SLC9A10

Previous GeneCards Identifiers for SLC9C1 Gene

  • GC03M111860

Summaries for SLC9C1 Gene

Entrez Gene Summary for SLC9C1 Gene

  • SLC9A10 is a member of the sodium-hydrogen exchanger (NHE) family (see SLC9A1, MIM 107310) and is required for male fertility and sperm motility (Wang et al., 2003 [PubMed 14634667]).[supplied by OMIM, Apr 2009]

GeneCards Summary for SLC9C1 Gene

SLC9C1 (Solute Carrier Family 9, Subfamily C (Na+-Transporting Carboxylic Acid Decarboxylase), Member 1) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include solute:proton antiporter activity. An important paralog of this gene is SLC9C2.

UniProtKB/Swiss-Prot for SLC9C1 Gene

  • Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity).

Gene Wiki entry for SLC9C1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC9C1 Gene

Genomics for SLC9C1 Gene

Genomic Location for SLC9C1 Gene

Start:
112,140,772 bp from pter
End:
112,294,258 bp from pter
Size:
153,487 bases
Orientation:
Minus strand

Genomic View for SLC9C1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC9C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC9C1 Gene

No data available for Regulatory Elements for SLC9C1 Gene

Proteins for SLC9C1 Gene

  • Protein details for SLC9C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0N8-SL9C1_HUMAN
    Recommended name:
    Sodium/hydrogen exchanger 10
    Protein Accession:
    Q4G0N8
    Secondary Accessions:
    • Q6ZRP4
    • Q7RTP2

    Protein attributes for SLC9C1 Gene

    Size:
    1177 amino acids
    Molecular mass:
    135206 Da
    Quaternary structure:
    • Interacts with soluble adenylyl cyclase (sAC).
    SequenceCaution:
    • Sequence=DAA01462.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC9C1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC9C1 Gene

Proteomics data for SLC9C1 Gene at MOPED

Post-translational modifications for SLC9C1 Gene

  • Glycosylation at Asn278
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC9C1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC9C1 Gene

Domains for SLC9C1 Gene

Gene Families for SLC9C1 Gene

Graphical View of Domain Structure for InterPro Entry

Q4G0N8

UniProtKB/Swiss-Prot:

SL9C1_HUMAN :
  • Q4G0N8
Domain:
  • The ion transport-like region is related to the membrane segments of voltage-gated ion channels. Its function is unknown (By similarity).
  • Contains 1 cyclic nucleotide-binding domain.
Family:
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
genes like me logo Genes that share domains with SLC9C1: view

No data available for Suggested Antigen Peptide Sequences for SLC9C1 Gene

Function for SLC9C1 Gene

Molecular function for SLC9C1 Gene

UniProtKB/Swiss-Prot Function: Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity).

Gene Ontology (GO) - Molecular Function for SLC9C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015299 solute:proton antiporter activity IEA --
genes like me logo Genes that share ontologies with SLC9C1: view

Phenotypes for SLC9C1 Gene

MGI mutant phenotypes for SLC9C1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SLC9C1: view

Animal Models for SLC9C1 Gene

MGI Knock Outs for SLC9C1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC9C1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC9C1 Gene

Localization for SLC9C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC9C1 Gene

Cell projection, cilium, flagellum membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SLC9C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with SLC9C1: view

No data available for Subcellular locations from COMPARTMENTS for SLC9C1 Gene

Pathways for SLC9C1 Gene

genes like me logo Genes that share pathways with SLC9C1: view

Pathways by source for SLC9C1 Gene

Interacting Proteins for SLC9C1 Gene

Gene Ontology (GO) - Biological Process for SLC9C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport --
GO:0006814 sodium ion transport IEA --
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SLC9C1: view

Transcripts for SLC9C1 Gene

mRNA/cDNA for SLC9C1 Gene

(19) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC9C1 Gene

Solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC9C1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC9C1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC9C1 Gene

No ASD Table

Relevant External Links for SLC9C1 Gene

GeneLoc Exon Structure for
SLC9C1
ECgene alternative splicing isoforms for
SLC9C1

Expression for SLC9C1 Gene

mRNA expression in normal human tissues for SLC9C1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC9C1 Gene

This gene is overexpressed in Testis (23.7) and Heart - Left Ventricle (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC9C1 Gene

SOURCE GeneReport for Unigene cluster for SLC9C1 Gene Hs.680112

genes like me logo Genes that share expressions with SLC9C1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC9C1 Gene

Orthologs for SLC9C1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC9C1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC9C1 35
  • 99.03 (n)
  • 98.15 (a)
SLC9C1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC9C1 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC9C1 35
  • 82.89 (n)
  • 72.86 (a)
SLC9C1 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc9c1 35
  • 77.69 (n)
  • 69.31 (a)
Slc9c1 16
Slc9c1 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC9C1 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC9C1 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc9c1 35
  • 77.28 (n)
  • 69.75 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
Species with no ortholog for SLC9C1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC9C1 Gene

ENSEMBL:
Gene Tree for SLC9C1 (if available)
TreeFam:
Gene Tree for SLC9C1 (if available)

Paralogs for SLC9C1 Gene

Paralogs for SLC9C1 Gene

Selected SIMAP similar genes for SLC9C1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC9C1: view

Variants for SLC9C1 Gene

Sequence variations from dbSNP and Humsavar for SLC9C1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs958695 -- 112,220,013(+) CACAT(C/T)TGCCC intron-variant
rs1112229 -- 112,147,003(+) ATTTA(A/G)GATGA intron-variant
rs1119338 -- 112,253,685(+) aacca(A/G)tgcaa intron-variant
rs1119339 -- 112,253,797(+) cagaa(A/C)tagaa intron-variant
rs1304787 -- 112,254,850(-) gatga(A/G)agggg intron-variant

Relevant External Links for SLC9C1 Gene

HapMap Linkage Disequilibrium report
SLC9C1
Human Gene Mutation Database (HGMD)
SLC9C1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC9C1 Gene

Disorders for SLC9C1 Gene

No disorders were found for SLC9C1 Gene.

No data available for UniProtKB/Swiss-Prot for SLC9C1 Gene

Publications for SLC9C1 Gene

  1. Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. (PMID: 12783626) Oduru S. … Williams S.C. (BMC Genomics 2003) 2 3 4
  2. A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility. (PMID: 14634667) Wang D. … Garbers D.L. (Nat. Cell Biol. 2003) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Role of the Na(+)/H(+) exchanger on the development of diabetes mellitus and its chronic complications. (PMID: 23000155) Sun Y.M. … Wang L.F. (Biochem. Biophys. Res. Commun. 2012) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for SLC9C1 Gene

Sources for SLC9C1 Gene

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