Aliases for SLC9C1 Gene
External Ids for SLC9C1 Gene
Previous Symbols for SLC9C1 Gene
SLC9A10 is a member of the sodium-hydrogen exchanger (NHE) family (see SLC9A1, MIM 107310) and is required for male fertility and sperm motility (Wang et al., 2003 [PubMed 14634667]).[supplied by OMIM, Apr 2009]
GeneCards Summary for SLC9C1 Gene
SLC9C1 (Solute Carrier Family 9, Subfamily C (Na+-Transporting Carboxylic Acid Decarboxylase), Member 1) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include solute:proton antiporter activity. An important paralog of this gene is SLC9C2.
UniProtKB/Swiss-Prot for SLC9C1 Gene
Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity).