Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC9C1 Gene

protein-coding   GIFtS: 41
GCID: GC03M111860

Solute Carrier Family 9, Subfamily C (Na+-Transporting Carboxylic...

(Previous names: solute carrier family 9, isoform 10, solute carrier family...)
(Previous symbol: SLC9A10)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 9, Subfamily C (Na+-Transporting Carboxylic Acid
Decarboxylase), Member 11 2
     sNHE2 3
SLC9A101 2 3 5     Solute Carrier Family 9, Isoform 101
Solute Carrier Family 9, Member 101 2     NHE2
sperm-NHE1 2     Sodium/Hydrogen Exchanger 102
Solute Carrier Family 9 Member C12 3     Solute Carrier Family 10 Member 102
Sperm-Specific Na(+)/H(+) Exchanger2 3     Solute Carrier Family 92
NHE-102 3     Sperm-Specific Sodium Proton Exchanger2
Na(+)/H(+) Exchanger 102 3     Solute Carrier Family 9 Member 103

External Ids:    HGNC: 314011   Entrez Gene: 2853352   Ensembl: ENSG000001721397   OMIM: 6127385   UniProtKB: Q4G0N83   

Export aliases for SLC9C1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SLC9C1 Gene:
SLC9A10 is a member of the sodium-hydrogen exchanger (NHE) family (see SLC9A1, MIM 107310) and is required for
male fertility and sperm motility (Wang et al., 2003 (PubMed 14634667)).(supplied by OMIM, Apr 2009)

GeneCards Summary for SLC9C1 Gene:
SLC9C1 (solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1) is a protein-coding gene. Diseases associated with SLC9C1 include pneumonia, and diabetes mellitus. GO annotations related to this gene include solute:hydrogen antiporter activity. An important paralog of this gene is SLC9C2.

UniProtKB/Swiss-Prot: SL9C1_HUMAN, Q4G0N8
Function: Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa.
Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm
motility which is essential late in the preparation of sperm for fertilization. Required for the expression and
bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity)

Gene Wiki entry for SLC9C1 (SLC9A10) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Search for regulatory transcription factor binding sites for SLC9C1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC9C1 promoter sequence
   Search Chromatin IP Primers for SLC9C1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC9C1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.2   Ensembl cytogenetic band:  3q13.2   HGNC cytogenetic band: 3q13

SLC9C1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC9C1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M111860:  view genomic region     (about GC identifiers)

Start:
111,859,734 bp from pter      End:
112,013,105 bp from pter
Size:
153,372 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SL9C1_HUMAN, Q4G0N8 (See protein sequence)
Recommended Name: Sodium/hydrogen exchanger 10  
Size: 1177 amino acids; 135206 Da
Subunit: Interacts with soluble adenylyl cyclase (sAC) (By similarity)
Sequence caution: Sequence=DAA01462.1; Type=Erroneous gene model prediction;
Secondary accessions: Q6ZRP4 Q7RTP2
Alternative splicing: 2 isoforms:  Q4G0N8-1   Q4G0N8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC9C1: NX_Q4G0N8

Explore proteomics data for SLC9C1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn278

  • See SLC9C1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_898884.1  
    ENSEMBL proteins: 
     ENSP00000306627   ENSP00000420688   ENSP00000418371   ENSP00000417274  
    Reactome Protein details: Q4G0N8

    SLC9C1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SLC9C1
    GenScript Custom Purified and Recombinant Proteins Services for SLC9C1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SLC9C1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC9C1
    Novus Biologicals SLC9C1 Antibodies
    Search for Antibodies for SLC9C1 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for SLC9C1
    Search LSBio for Antibodies for SLC9C1

    SLC9C1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC9C1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC9C1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Sodium/hydrogen exchanger 10
    SLC9 family of sodium/hydrogen exchangers

    Selected InterPro protein domains (see all 6):
     IPR006153 Cation/H_exchanger
     IPR018490 cNMP-bd-like
     IPR000595 cNMP-bd_dom
     IPR018422 Cation/H_exchanger_CPA1
     IPR028483 N/H_exchanger_10

    Graphical View of Domain Structure for InterPro Entry Q4G0N8

    ProtoNet protein and cluster: Q4G0N8

    2 Blocks protein domains:
    IPB000595 Cyclic nucleotide-binding domain
    IPB006153 Sodium/hydrogen exchanger


    UniProtKB/Swiss-Prot: SL9C1_HUMAN, Q4G0N8
    Domain: The ion transport-like region is related to the membrane segments of voltage-gated ion channels. Its
    function is unknown (By similarity)
    Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
    Similarity: Contains 1 cyclic nucleotide-binding domain


    SLC9C1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SL9C1_HUMAN, Q4G0N8
    Function: Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa.
    Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm
    motility which is essential late in the preparation of sperm for fertilization. Required for the expression and
    bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015299solute:hydrogen antiporter activity IEA--
         
    SLC9C1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Slc9c1):
     reproductive system 

    SLC9C1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc9c1tm1Gar for SLC9C1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC9C1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC9C1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC9C1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC9C1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SLC9C1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SLC9C1
    SwitchGear 3'UTR luciferase reporter plasmidSLC9C1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC9C1
    Predesigned siRNA for gene silencing in human, mouse, rat SLC9C1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC9C1

    Clone
    Products:
         
    OriGene clones in human, mouse for SLC9C1 (see all 6)
    OriGene ORF clones in mouse, rat for SLC9C1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SLC9C1
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC9C1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9C1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC9C1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC9C1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9C1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SL9C1_HUMAN, Q4G0N8: Cell projection, cilium, flagellum membrane; Multi-pass membrane protein (By similarity)

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0031514motile cilium IEA--

    SLC9C1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SLC9C1 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC9C1
        Stimuli-sensing channels



    SLC9C1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC9C1
    Interactions:

        Search GeneGlobe Interaction Network for SLC9C1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for SLC9C1 (ENSP000003066274) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMCO3ENSP000003893994STRING: ENSP00000389399
    CHMP6ENSP000003174684STRING: ENSP00000317468
    CRLS1ENSP000003681404STRING: ENSP00000368140
    TBC1D5ENSP000004029354STRING: ENSP00000402935
    VPS36ENSP000003672994STRING: ENSP00000367299
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport ----
    GO:0006814sodium ion transport IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--

    SLC9C1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC9C1 (SL9C1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLC9C1 gene: 
    NM_183061.1  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305815(uc003dyu.3) ENST00000487372(uc011bhu.2 uc010hqc.3)
    ENST00000471295 ENST00000486574 ENST00000467397
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC9C1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SLC9C1
    SwitchGear 3'UTR luciferase reporter plasmidSLC9C1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC9C1
    Predesigned siRNA for gene silencing in human, mouse, rat SLC9C1
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC9C1 (see all 6)
    OriGene ORF clones in mouse, rat for SLC9C1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SLC9C1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC9C1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9C1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC9C1
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SLC9C1
      QuantiTect SYBR Green Assays in human, mouse, rat SLC9C1
      QuantiFast Probe-based Assays in human, mouse, rat SLC9C1

    5 AceView cDNA sequences:

    BK001328 BC044801 AK128084 BG717374 BG722974 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLC9C1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAACATTCA
    SLC9C1 Expression
    About this image


    SLC9C1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Testis (Reproductive System)
             Mature Sertoli Cells Seminiferous Tubules
    SLC9C1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC9C1 Protein Expression
        Custom PCR Arrays for SLC9C1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC9C1
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SLC9C1
    QuantiTect SYBR Green Assays in human, mouse, rat SLC9C1
    QuantiFast Probe-based Assays in human, mouse, rat SLC9C1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9C1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for SLC9C1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc9c11 , 5 solute carrier family 9, member 105
    solute carrier family 9, subfamily C (Na+-transporting more1
    77.69(n)1
    69.31(a)1
      16 (29.53 cM)5
    2081691  NM_198106.41  NP_932774.31 
     455353095 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    36(a)
    1 → many
    1(75660752-75769510)


    ENSEMBL Gene Tree for SLC9C1 (if available)
    TreeFam Gene Tree for SLC9C1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLC9C1 gene
    SLC9C22  
    2 SIMAP similar genes for SLC9C1 using alignment to 3 protein entries:     SL9C1_HUMAN (see all proteins):
    SCN5A    SLC9C2

    SLC9C1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SLC9C1 (see all 3380)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1435722671,2
    --111859312(+) CAGATA/GTCTAT 1 -- int10--------
    rs119281301,2
    C,F,A,H--111859362(+) GTTTTC/GAAATC 1 -- int113Minor allele frequency- G:0.35NS EA NA CSA WA 790
    rs133193701,2
    C,F,H--111859428(+) GAATAA/CTTGTA 1 -- int15Minor allele frequency- C:0.02NS EA WA 520
    rs1480597681,2
    --111859509(+) AGAAAA/GCATGC 1 -- int10--------
    rs105113061,2
    C,F,A,H--111859525(+) TTCTTC/GACTGT 1 -- int197Minor allele frequency- G:0.34NS EA NA PA EU CA WA CSA 4882
    rs354113581,2
    C,F--111859667(+) TCACTA/GTTATA 1 -- int17Minor allele frequency- G:0.33NA EA 250
    rs1131093291,2
    F--111859690(+) CTACCG/AAGATG 1 -- int12Minor allele frequency- A:0.06CSA WA 120
    rs105113071,2
    C,F,A,H--111859734(+) TGGATC/GAAGAA 1 -- int1114Minor allele frequency- G:0.33NS EA NA PA EU CA WA CSA 7224
    rs1417893491,2
    C--111859755(+) ACTATA/CTTTTA 1 -- ut310--------
    rs119205681,2
    C,F,H--111859779(+) TTCATA/GAAGTG 1 -- ut316Minor allele frequency- G:0.01NS EA NA CSA 408

    HapMap Linkage Disequilibrium report for SLC9C1 (111859734 - 112013105 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC9C1: --
    Human Gene Mutation Database (HGMD): SLC9C1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC9C1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC9C1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612738    OMIM disorders: --

    2 diseases for SLC9C1:    
    About MalaCards
    pneumonia    diabetes mellitus


    SLC9C1 for disorders           About GeneDecksing


    Export disorders for SLC9C1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLC9C1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SLC9C1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. (PubMed id 12783626)1, 2, 3 Oduru S....Williams S.C. (BMC Genomics 2003)
    2. Role of the Na(+)/H(+) exchanger on the development of diabetes mellitus and its chronic complications. (PubMed id 23000155)1 Sun Y.M....Wang L.F. (Biochem. Biophys. Res. Commun. 2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility. (PubMed id 14634667)1 Wang D....Garbers D.L. (Nat. Cell Biol. 2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 285335 HGNC: 31401 AceView: LOC285335 Ensembl:ENSG00000172139 euGenes: HUgn285335
    ECgene: SLC9C1 H-InvDB: SLC9C1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC9C1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLC9C1 gene:
    Search GeneIP for patents involving SLC9C1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC9C1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC9C1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC9C1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC9C1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC9C1   OriGene Custom Protein Services for SLC9C1  

     
     
     Block miRNA regulation of human, mouse, rat SLC9C1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC9C1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC9C1 Predesigned siRNA for gene silencing in human, mouse, rat SLC9C1
     QuantiFast Probe-based Assays in human, mouse, rat SLC9C1 QuantiTect SYBR Green Assays in human, mouse, rat SLC9C1
     Custom PCR Arrays for SLC9C1 Search Chromatin IP Primers for SLC9C1
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SLC9C1 Search GeneGlobe Interaction Network for SLC9C1
     Search Regulatory tfbs for SLC9C1
     GenScript Custom Purified and Recombinant Proteins Services for SLC9C1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for SLC9C1
     GenScript Custom Assay Services for SLC9C1 GenScript Custom overexpressing Cell Line Services for SLC9C1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLC9C1 (SL9C1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLC9C1 antibodies
     Search for Antibodies for SLC9C1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SLC9C1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC9C1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9C1
     SwitchGear 3'UTR luciferase reporter plasmids for SLC9C1
     SwitchGear Promoter luciferase reporter plasmids for SLC9C1
     Search ThermoFisher Antibodies for SLC9C1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9C1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC9C1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC9C1
     Search LSBio for Antibodies for SLC9C1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC9C1 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4