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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC9B2 Gene

protein-coding GIFtS: 47
GCID: GC04M103946

solute carrier family 9, subfamily B (NHA2, cation proton...

(Previous names: Na+/H+ exchanger domain containing 2, solute carrier family...)
(Previous symbol: NHEDC2)

Explore 4 diseases affiliated with
SLC9B2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 9, Subfamily B (NHA2, Cation Proton Antiporter 2), Member 2¹ ²		Solute Carrier Family 9 Subfamily B Member 2² ³
NHA2¹ ² ³ ⁵		Na(+)/H(+) Exchanger-Like Domain-Containing Protein 2² ³
NHEDC2¹ ² ³ ⁵		NHE Domain-Containing Protein 2² ³
Na+/H+ Exchanger Domain Containing 2¹ ²		FLJ23984¹
Solute Carrier Family 9, Subfamily B (Cation Proton Antiporter 2), Member 2¹ ²		NHE10²
Mitochondrial Na(+)/H(+) Exchanger NHA2² ³		Mitochondrial Sodium/Hydrogen Exchanger 9B2²
Sodium/Hydrogen Exchanger-Like Domain-Containing Protein 2² ³		Mitochondrial Sodium/Hydrogen Exchanger NHA2²

External Ids:	HGNC: 25143¹	Entrez Gene: 133308²	Ensembl: ENSG00000164038⁷	OMIM: 611789⁵	UniProtKB: Q86UD5³

Export aliases for SLC9B2 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC9B2:

Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or

the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce

environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 (PubMed 18000046)).(supplied

by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: SL9B2_HUMAN, Q86UD5

Function: Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes

to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By

similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for SLC9B2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC9B2 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC9B2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC9B2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q24 Ensembl cytogenetic band: 4q24 HGNC cytogenetic band: 4q24

SLC9B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC9B2 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M103946: view genomic region (about GC identifiers)

Start:	103,941,025 bp from pter	End:	104,006,986 bp from pter
Size:	65,962 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SL9B2_HUMAN, Q86UD5 (See protein sequence)

Recommended Name: Mitochondrial sodium/hydrogen exchanger 9B2

Size: 537 amino acids; 57564 Da

Subcellular location: Mitochondrion membrane; Multi-pass membrane protein (By similarity)

Secondary accessions: B5ME52 Q6ZMD8 Q96D95

Alternative splicing: 2 isoforms: Q86UD5-1 Q86UD5-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC9B2: NX_Q86UD5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86UD5

SLC9B2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_849155.2

ENSEMBL proteins:

ENSP00000354574 ENSP00000421943 ENSP00000378265 ENSP00000425385 ENSP00000422477

ENSP00000426305 ENSP00000423496 ENSP00000345241

Reactome Protein details: Q86UD5
Human Recombinant Protein Products for SLC9B2:

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	Uscn Proteins for SLC9B2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--
GO:0031966	mitochondrial membrane	IEA	--

SLC9B2 for ontologies About GeneDecksing

SLC9B2 Antibody Products:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC9B2 for domains About GeneDecksing

1 InterPro domain/family:

IPR006153 Cation/H_exchanger

Graphical View of Domain Structure for InterPro Entry Q86UD5

ProtoNet protein and cluster: Q86UD5

1 Blocks protein family: IPB006153 Sodium/hydrogen exchanger

UniProtKB/Swiss-Prot: SL9B2_HUMAN, Q86UD5

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SL9B2_HUMAN, Q86UD5

Function: Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes

to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By

similarity)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	--	--
GO:0015299	solute:hydrogen antiporter activity	IEA	--
GO:0016491	oxidoreductase activity	--	--

SLC9B2 for ontologies About GeneDecksing

Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Slc9b2):

normal

SLC9B2 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC9B2

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9B2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ion channel transport

Ion channel transport

1.00

Stimuli-sensing channels

0.49

SLC-mediated transmembrane transport

Transmembrane transport of small molecules

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for SLC9B2

	Transmembrane transport of small molecules
	Stimuli-sensing channels
	Ion channel transport

SLC9B2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC9B2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

5 Interacting proteins for SLC9B2 (Q86UD5³ ENSP00000354574⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CTU2	Q2VPK5³	I2D: score=5
DENND6B	Q8NEG7³	I2D: score=5
RTFDC1	Q9BY42³	I2D: score=5
CACTIN	Q8WUQ7³	I2D: score=4
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006814	sodium ion transport	IEA	--

SLC9B2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC9B2
Search CenterWatch for drugs/clinical trials and news about SLC9B2 / SL9B2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC9B2 gene:

NM_178833.4

Unigene Cluster for SLC9B2:

Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2

Hs.546482 [show with all ESTs]

Unigene Representative Sequence: BX640844

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000362026(uc010iln.2) ENST00000506288 ENST00000394785(uc003hwx.4 uc003hwy.3 uc011cew.2)

ENST00000503103 ENST00000503230 ENST00000510976 ENST00000515424(uc011cey.2)

ENST00000503818 ENST00000505838 ENST00000508136 ENST00000512806 ENST00000339611(uc011cex.1)

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Additional cDNA sequence:

AK172823.1 AK297010.1 AK298506.1 AK299888.1 BC009732.1 BC047447.1 BX640844.1

15 DOTS entries:

DT.407073 DT.100679223 DT.40285522 DT.100712987 DT.95368440 DT.100775719 DT.405763 DT.91646431

DT.100664442 DT.121253271 DT.97793914 DT.70102815 DT.92417724 DT.91720702 DT.92007695

24/115 AceView cDNA sequences (see all 115):

AA233152 F10816 BC009732 AI367621 BQ286748 BM971864 BM834042 BF724498

BI914487 BX494716 BM683318 BI962996 AI239938 BX640844 BF724499 BX454520

BX381078 AA233228 BX359761 Z40158 BM702572 BM669493 BG284074 AF447585

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC9B2 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15
SP1:																	-								-		-								-
SP2:																	-								-		-
SP3:																	-								-		-				-		-		-
SP4:																									-
SP5:

ECgene alternative splicing isoforms for SLC9B2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC9B2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGGAAAAAAA

About this image

SLC9B2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Visceral White Adipocytes

Adipose

Brain

Blood Brain Barrier

Adult Endothelial Cells

Blood Brain Barrier, Endothelium

Bone

Stylopod Long Bone

Bone

Zeugopod Periosteum

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC9B2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC9B2

SOURCE GeneReport for Unigene cluster: Hs.546482

UniProtKB/Swiss-Prot: SL9B2_HUMAN, Q86UD5

Tissue specificity: Detected in red blood cells (at protein level)

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SLC9B2 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Slc9b2⁵ Nhedc2¹	Na+/H+ exchanger domain containing 2^{1, 5}	81.9(n)¹ 81.34(a)¹		3 (62.55 cM)⁵ 97086¹ NM_178877.6¹ NP_849208.4¹ 135307700⁵
chicken (Gallus gallus)	Aves	NHEDC2¹	Na+/H+ exchanger domain containing 2	69.16(n) 68.58(a)		428776 XM_426332.3 XP_426332.2
zebrafish (Danio rerio)	Actinopterygii	LOC571064¹	mitochondrial sodium/hydrogen exchanger NHA2-like	62.57(n) 66.74(a)		571064 XM_694618.2 XP_699710.2
fruit fly (Drosophila melanogaster)	Insecta	Nha1¹	Na[+]/H[+] hydrogen antiporter 1	46.91(n) 37.07(a)		33961 NM_164717.1 NP_723224.2
worm (Caenorhabditis elegans)	Secernentea	F57G8.5⁶ F41E7.1⁶ (see all 3)	Protein F41E7.1 (see all 3)	23(a) 23(a) (see all 3)	possible ortholog possible ortholog (see all 3)	V(16339004-16341514) X(10279540-10282786)

ENSEMBL Gene Tree for SLC9B2 (if available)
TreeFam Gene Tree for SLC9B2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC9B2 gene

SLC9B1P1² SLC9B1²

3 SIMAP similar genes for SLC9B2 using alignment to 5 protein entries: SL9B2_HUMAN (see all proteins):

BDH2 SLC9B1 SLC9B1P1

SLC9B2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147370810^1,2		--	103946230(+)	`TAGGAA/GTGTGA`	1	--	int¹		0	--	--	--	--
rs184898576^1,2		--	103946280(+)	`GATATC/GATCAA`	1	--	int¹		0	--	--	--	--
rs139471414^1,2		--	103946330(+)	`CATCAC/TTTCCT`	1	--	int¹		0	--	--	--	--
rs189909865^1,2		--	103946385(+)	`GGAGAC/TATGGT`	1	--	int¹		0	--	--	--	--
rs183839588^1,2		--	103946394(+)	`GTAGAC/GATCCA`	1	--	int¹		0	--	--	--	--
rs72943512^1,2	C	--	103946619(+)	`GAGTAT/ACCCTG`	1	--	int¹		1		WA	2
rs114494669^1,2	F	--	103946635(+)	`ATTAAC/TGAACC`	1	--	int¹		1		WA	118
rs115231456^1,2	F	--	103946872(+)	`GCCACT/AGAAAT`	1	--	ut3¹		1		WA	118
rs149446343^1,2		--	103946914(+)	`GATAAA/GGTTTT`	1	--	ut3¹		0	--	--	--	--
rs76842810^1,2		--	103947024(+)	`AGTAAC/GGGAAG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLC9B2 (103941025 - 104006986 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC9B2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC9B2

DNA2.0 Custom Variant and Variant Library Synthesis for SLC9B2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC9B2 for disorders           About GeneDecksing

OMIM gene information: 611789    OMIM disorders: --

4 diseases for SLC9B2:    About MalaCards

alcohol dependence essential hypertension hypertension alcoholism

Export disorders for SLC9B2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLC9B2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with SLC9B2)

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Proteomic profile of osteoclast membrane proteins: identification of Na+/H+ exchanger domain containing 2 and its role in osteoclast fusion. (PubMed id 18600791)^{1, 3} Ha B.G....Park E.K. (2008)
A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension. (PubMed id 18000046)^{1, 2} Xiang M.... Rao R. (2007)
Unconventional chemiosmotic coupling of NHA2, a mammal ian Na+/H+ antiporter, to a plasma membrane H+ gradient. (PubMed id 22948142)¹ Kondapalli K.C....Rao R. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)¹ Kalsi G....Riley B.P. (2010)
Mutational analysis of NHAoc/NHA2 in Saccharomyces ce revisiae. (PubMed id 20713131)¹ Huang X....Battaglino R.A. (2010)
Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension. (PubMed id 20053353)¹ Schushan M....Ben-Tal N. (2010)
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts. (PubMed id 17988971)¹ Battaglino R.A....Stashenko P. (2008)
Characterization of the sodium/hydrogen exchanger NHA2. (PubMed id 18508966)¹ Fuster D.G....Moe O.W. (2008)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 133308	HGNC: 25143	AceView: LOC150159	Ensembl:ENSG00000164038	euGenes: HUgn133308
ECgene: SLC9B2	H-InvDB: SLC9B2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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Name	Description
PharmGKB entry for SLC9B2	Pharmacogenomics, SNPs, Pathways

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SLC9B2 Gene

solute carrier family 9, subfamily B (NHA2, cation proton...

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solute carrier family 9, subfamily B (NHA2, cation proton...

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