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Aliases for SLC9B2 Gene

Aliases for SLC9B2 Gene

  • Solute Carrier Family 9, Subfamily B (NHA2, Cation Proton Antiporter 2), Member 2 2 3
  • NHEDC2 3 4 6
  • NHA2 3 4 6
  • Solute Carrier Family 9, Subfamily B (Cation Proton Antiporter 2), Member 2 2 3
  • Sodium/Hydrogen Exchanger-Like Domain-Containing Protein 2 3 4
  • Na(+)/H(+) Exchanger-Like Domain-Containing Protein 2 3 4
  • Solute Carrier Family 9 Subfamily B Member 2 3 4
  • Mitochondrial Na(+)/H(+) Exchanger NHA2 3 4
  • Na+/H+ Exchanger Domain Containing 2 2 3
  • NHE Domain-Containing Protein 2 3 4
  • Mitochondrial Sodium/Hydrogen Exchanger NHA2 3
  • Mitochondrial Sodium/Hydrogen Exchanger 9B2 3
  • NHE10 3

External Ids for SLC9B2 Gene

Previous HGNC Symbols for SLC9B2 Gene

  • NHEDC2

Previous GeneCards Identifiers for SLC9B2 Gene

  • GC04M103946

Summaries for SLC9B2 Gene

Entrez Gene Summary for SLC9B2 Gene

  • Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC9B2 Gene

SLC9B2 (Solute Carrier Family 9, Subfamily B (NHA2, Cation Proton Antiporter 2), Member 2) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include solute:proton antiporter activity. An important paralog of this gene is SLC9B1.

UniProtKB/Swiss-Prot for SLC9B2 Gene

  • Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC9B2 Gene

Genomics for SLC9B2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC9B2 Gene

Start:
103,019,868 bp from pter
End:
103,085,829 bp from pter
Size:
65,962 bases
Orientation:
Minus strand

Genomic View for SLC9B2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC9B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC9B2 Gene

No data available for Regulatory Elements for SLC9B2 Gene

Proteins for SLC9B2 Gene

  • Protein details for SLC9B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UD5-SL9B2_HUMAN
    Recommended name:
    Mitochondrial sodium/hydrogen exchanger 9B2
    Protein Accession:
    Q86UD5
    Secondary Accessions:
    • B5ME52
    • Q6ZMD8
    • Q96D95

    Protein attributes for SLC9B2 Gene

    Size:
    537 amino acids
    Molecular mass:
    57564 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC9B2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC9B2 Gene

Proteomics data for SLC9B2 Gene at MOPED

Post-translational modifications for SLC9B2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC9B2 Gene

No data available for DME Specific Peptides for SLC9B2 Gene

Domains for SLC9B2 Gene

Gene Families for SLC9B2 Gene

HGNC:
  • SLC :Solute carriers

Protein Domains for SLC9B2 Gene

Graphical View of Domain Structure for InterPro Entry

Q86UD5

UniProtKB/Swiss-Prot:

SL9B2_HUMAN :
  • Q86UD5
Family:
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
genes like me logo Genes that share domains with SLC9B2: view

No data available for Suggested Antigen Peptide Sequences for SLC9B2 Gene

Function for SLC9B2 Gene

Molecular function for SLC9B2 Gene

UniProtKB/Swiss-Prot Function: Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity).

Gene Ontology (GO) - Molecular Function for SLC9B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015299 solute:proton antiporter activity IEA --
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with SLC9B2: view
genes like me logo Genes that share phenotypes with SLC9B2: view

Animal Models for SLC9B2 Gene

MGI Knock Outs for SLC9B2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC9B2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC9B2 Gene

Localization for SLC9B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC9B2 Gene

Mitochondrion membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SLC9B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC9B2: view

No data available for Subcellular locations from COMPARTMENTS for SLC9B2 Gene

Pathways for SLC9B2 Gene

genes like me logo Genes that share pathways with SLC9B2: view

Pathways by source for SLC9B2 Gene

Interacting Proteins for SLC9B2 Gene

Gene Ontology (GO) - Biological Process for SLC9B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport --
GO:0006814 sodium ion transport IEA --
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
GO:0055114 oxidation-reduction process --
genes like me logo Genes that share ontologies with SLC9B2: view

Transcripts for SLC9B2 Gene

Unigene Clusters for SLC9B2 Gene

Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC9B2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC9B2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP4: -
SP5:

Relevant External Links for SLC9B2 Gene

GeneLoc Exon Structure for
SLC9B2
ECgene alternative splicing isoforms for
SLC9B2

Expression for SLC9B2 Gene

mRNA expression in normal human tissues for SLC9B2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC9B2 Gene

SOURCE GeneReport for Unigene cluster for SLC9B2 Gene Hs.546482

mRNA Expression by UniProt/SwissProt for SLC9B2 Gene

Q86UD5-SL9B2_HUMAN
Tissue specificity: Detected in red blood cells (at protein level)
genes like me logo Genes that share expressions with SLC9B2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLC9B2 Gene

Orthologs for SLC9B2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC9B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NHEDC2 35
  • 99.57 (n)
  • 99.63 (a)
SLC9B2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC9B2 35
  • 86.73 (n)
  • 83.74 (a)
SLC9B2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC9B2 35
  • 88.83 (n)
  • 86.96 (a)
SLC9B2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc9b2 35
  • 81.9 (n)
  • 81.34 (a)
Slc9b2 16
Slc9b2 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC9B2 36
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC9B2 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc9b2 35
  • 82.4 (n)
  • 81.72 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 64 (a)
OneToMany
NHEDC2 35
  • 69.06 (n)
  • 68.11 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc9b2 35
  • 68.2 (n)
  • 67.47 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01072557.1 36
  • 66 (a)
ManyToMany
CU695013.3 36
  • 44 (a)
ManyToMany
si:dkey-162b23.4 35
  • 62.31 (n)
  • 66.3 (a)
si:dkey-162b23.4 36
  • 54 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002093 35
  • 47.68 (n)
  • 39.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nha1 35
  • 45.88 (n)
  • 35.86 (a)
Nha1 36
  • 23 (a)
ManyToMany
Nha2 36
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F41E7.1 36
  • 23 (a)
ManyToMany
F41E7.2 36
  • 18 (a)
ManyToMany
F57G8.5 36
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6614 36
  • 51 (a)
OneToMany
Species with no ortholog for SLC9B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC9B2 Gene

ENSEMBL:
Gene Tree for SLC9B2 (if available)
TreeFam:
Gene Tree for SLC9B2 (if available)

Paralogs for SLC9B2 Gene

Paralogs for SLC9B2 Gene

Selected SIMAP similar genes for SLC9B2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC9B2: view

Variants for SLC9B2 Gene

Sequence variations from dbSNP and Humsavar for SLC9B2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1080081 -- 103,029,268(-) ACATT(A/G)TACAT intron-variant
rs1383732 -- 103,032,232(+) CCCCT(A/G)TTACT intron-variant
rs1481279 -- 103,056,781(-) CATAG(A/T)TGGTT intron-variant
rs2276976 - 103,043,372(+) AACCA(A/C)AATGC missense, reference, nc-transcript-variant
rs2866631 -- 103,070,446(-) aaaca(A/C)acaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC9B2 Gene

Variant ID Type Subtype PubMed ID
dgv1656e1 CNV Complex 17122850
nsv461598 CNV Loss 19166990
nsv4445 CNV Insertion 18451855
nsv830021 CNV Loss 17160897
nsv4446 CNV Insertion 18451855

Relevant External Links for SLC9B2 Gene

HapMap Linkage Disequilibrium report
SLC9B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC9B2 Gene

Disorders for SLC9B2 Gene

No disorders were found for SLC9B2 Gene.

No data available for UniProtKB/Swiss-Prot for SLC9B2 Gene

Publications for SLC9B2 Gene

  1. Proteomic profile of osteoclast membrane proteins: identification of Na+/H+ exchanger domain containing 2 and its role in osteoclast fusion. (PMID: 18600791) Ha B.G. … Park E.K. (Proteomics 2008) 2 3
  2. A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension. (PMID: 18000046) Xiang M. … Rao R. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4
  3. Characterization of the sodium/hydrogen exchanger NHA2. (PMID: 18508966) Fuster D.G. … Moe O.W. (J. Am. Soc. Nephrol. 2008) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts. (PMID: 17988971) Battaglino R.A. … Stashenko P. (Bone 2008) 3

Products for SLC9B2 Gene

  • antibodies-online peptides for SLC9B2
  • antibodies-online antibodies for SLC9B2
  • antibodies-online kits for SLC9B2

Sources for SLC9B2 Gene

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