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Aliases for SLC9B2 Gene

Aliases for SLC9B2 Gene

  • Solute Carrier Family 9 Member B2 2 3 5
  • Solute Carrier Family 9, Subfamily B (NHA2, Cation Proton Antiporter 2), Member 2 2 3
  • Solute Carrier Family 9, Subfamily B (Cation Proton Antiporter 2), Member 2 2 3
  • Sodium/Hydrogen Exchanger-Like Domain-Containing Protein 2 3 4
  • Na(+)/H(+) Exchanger-Like Domain-Containing Protein 2 3 4
  • Solute Carrier Family 9 Subfamily B Member 2 3 4
  • Na+/H+ Exchanger Domain Containing 2 2 3
  • NHE Domain-Containing Protein 2 3 4
  • Na(+)/H(+) Exchanger NHA2 3 4
  • NHEDC2 3 4
  • NHA2 3 4
  • Mitochondrial Sodium/Hydrogen Exchanger NHA2 3
  • Mitochondrial Sodium/Hydrogen Exchanger 9B2 3
  • Mitochondrial Na(+)/H(+) Exchanger NHA2 3
  • Sodium/Hydrogen Exchanger 9B2 3
  • NHE10 3

External Ids for SLC9B2 Gene

Previous HGNC Symbols for SLC9B2 Gene

  • NHEDC2

Previous GeneCards Identifiers for SLC9B2 Gene

  • GC04M103946

Summaries for SLC9B2 Gene

Entrez Gene Summary for SLC9B2 Gene

  • Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC9B2 Gene

SLC9B2 (Solute Carrier Family 9 Member B2) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include oxidoreductase activity and solute:proton antiporter activity. An important paralog of this gene is SLC9B1.

UniProtKB/Swiss-Prot for SLC9B2 Gene

  • Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:18000046, PubMed:28154142, PubMed:22948142, PubMed:18508966). Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity).

Additional gene information for SLC9B2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC9B2 Gene

Genomics for SLC9B2 Gene

Regulatory Elements for SLC9B2 Gene

Enhancers for SLC9B2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H102596 1.2 FANTOM5 ENCODE dbSUPER 10.5 +487.1 487072 3 HLF IKZF1 JUNB RUNX3 CREM NFKB1 SLC9B2 SLC39A8 ENSG00000260651 MANBA BDH2 UBE2D3 SLC9B1 LOC105377347 LOC105377621
GH04H102733 1.6 FANTOM5 Ensembl ENCODE dbSUPER 4.6 +351.2 351156 2 SOX13 FOXA2 MAX FEZF1 FOSL1 RERE FOS RUNX3 CREM NR2F1 MANBA NFKB1 SLC39A8 SLC9B2 UBE2D3 SLC9B1 GC04P102735 PIR57038
GH04H102758 0.7 FANTOM5 dbSUPER 4.7 +326.8 326849 0 MLLT1 MANBA NFKB1 UBE2D3 SLC9B2 SLC39A8 SLC9B1 LOC100419096
GH04H103200 0.6 ENCODE 4.4 -115.2 -115162 1 MAFF ZNF316 FOXA2 ZSCAN4 MAFG SMAD4 EMSY MAFK BDH2 KRT8P46 SLC9B2 ENSG00000248161 CENPE LINC02428
GH04H103074 1.3 Ensembl ENCODE 0.4 +10.0 9974 3 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF207 MXD4 BDH2 SLC9B2 SLC9B1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC9B2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC9B2 Gene

Chromosome:
4
Start:
103,019,868 bp from pter
End:
103,085,829 bp from pter
Size:
65,962 bases
Orientation:
Minus strand

Genomic View for SLC9B2 Gene

Genes around SLC9B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC9B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC9B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC9B2 Gene

Proteins for SLC9B2 Gene

  • Protein details for SLC9B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UD5-SL9B2_HUMAN
    Recommended name:
    Sodium/hydrogen exchanger 9B2
    Protein Accession:
    Q86UD5
    Secondary Accessions:
    • B5ME52
    • Q6ZMD8
    • Q96D95

    Protein attributes for SLC9B2 Gene

    Size:
    537 amino acids
    Molecular mass:
    57564 Da
    Quaternary structure:
    • Homodimer (PubMed:28071645).
    Miscellaneous:
    • Inhibited by phloretin but not by the classical SLC9A-inhibitor amiloride (PubMed:18000046).

    Alternative splice isoforms for SLC9B2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC9B2 Gene

Post-translational modifications for SLC9B2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC9B2 Gene

Domains & Families for SLC9B2 Gene

Gene Families for SLC9B2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC9B2 Gene

Suggested Antigen Peptide Sequences for SLC9B2 Gene

Graphical View of Domain Structure for InterPro Entry

Q86UD5

UniProtKB/Swiss-Prot:

SL9B2_HUMAN :
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Family:
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
genes like me logo Genes that share domains with SLC9B2: view

Function for SLC9B2 Gene

Molecular function for SLC9B2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=33 mM for for Na(+) {ECO:0000269 PubMed:28154142}; KM=67 mM for for Li(+) {ECO:0000269 PubMed:28154142}; pH dependence: Optimum pH is 8.5. {ECO:0000269 PubMed:28154142};
UniProtKB/Swiss-Prot Function:
Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:18000046, PubMed:28154142, PubMed:22948142, PubMed:18508966). Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity).

Phenotypes From GWAS Catalog for SLC9B2 Gene

Gene Ontology (GO) - Molecular Function for SLC9B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005451 monovalent cation:proton antiporter activity TAS --
GO:0010348 lithium:proton antiporter activity IMP 18000046
GO:0015297 antiporter activity IEA --
GO:0015299 solute:proton antiporter activity IEA --
GO:0015385 sodium:proton antiporter activity IMP 18000046
genes like me logo Genes that share ontologies with SLC9B2: view
genes like me logo Genes that share phenotypes with SLC9B2: view

Animal Models for SLC9B2 Gene

MGI Knock Outs for SLC9B2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC9B2

CRISPR Products

miRNA for SLC9B2 Gene

miRTarBase miRNAs that target SLC9B2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC9B2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC9B2 Gene

Localization for SLC9B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC9B2 Gene

Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Strong colocalization with LAMP1 and TCIRG1 in osteoclasts. In beta-cells colocalizes with RAB4A and SYP. Localizes to the basolateral membrane of polarized osteoclasts. {ECO:0000250 UniProtKB:Q5BKR2}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC9B2 gene
Compartment Confidence
plasma membrane 5
mitochondrion 5
endosome 4
nucleus 2
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC9B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005768 endosome IEA --
GO:0005886 plasma membrane IEA,IDA 18000046
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with SLC9B2: view

Pathways & Interactions for SLC9B2 Gene

genes like me logo Genes that share pathways with SLC9B2: view

Pathways by source for SLC9B2 Gene

Gene Ontology (GO) - Biological Process for SLC9B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006812 cation transport IEA --
GO:0006814 sodium ion transport IDA,IEA 18508966
GO:0015992 proton transport IEA --
genes like me logo Genes that share ontologies with SLC9B2: view

No data available for SIGNOR curated interactions for SLC9B2 Gene

Drugs & Compounds for SLC9B2 Gene

No Compound Related Data Available

Transcripts for SLC9B2 Gene

Unigene Clusters for SLC9B2 Gene

Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC9B2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC9B2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP4: -
SP5:

Relevant External Links for SLC9B2 Gene

GeneLoc Exon Structure for
SLC9B2
ECgene alternative splicing isoforms for
SLC9B2

Expression for SLC9B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC9B2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC9B2 Gene

This gene is overexpressed in Liver (38.3), Cerebral cortex (18.9), and Fetal Brain (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC9B2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC9B2 Gene:

SLC9B2

SOURCE GeneReport for Unigene cluster for SLC9B2 Gene:

Hs.546482

mRNA Expression by UniProt/SwissProt for SLC9B2 Gene:

Q86UD5-SL9B2_HUMAN
Tissue specificity: Widely expressed (PubMed:18508966). High levels detected in the distal tubules of the kidney nephron (PubMed:18508966). Detected in red blood cells (at protein level) (PubMed:18000046, PubMed:18508966).

Evidence on tissue expression from TISSUES for SLC9B2 Gene

  • Liver(4.2)
  • Lung(4.2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with SLC9B2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC9B2 Gene

Orthologs for SLC9B2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC9B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC9B2 34
  • 100 (a)
OneToOne
NHEDC2 33
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia SLC9B2 33 34
  • 88.83 (n)
cow
(Bos Taurus)
Mammalia SLC9B2 33 34
  • 86.73 (n)
rat
(Rattus norvegicus)
Mammalia Slc9b2 33
  • 82.4 (n)
mouse
(Mus musculus)
Mammalia Slc9b2 33 16 34
  • 81.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC9B2 34
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC9B2 34
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves NHEDC2 33
  • 69.06 (n)
-- 34
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc9b2 33
  • 68.2 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01072557.1 34
  • 66 (a)
ManyToMany
si:dkey-162b23.4 33 34
  • 62.31 (n)
CU695013.3 34
  • 44 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002093 33
  • 47.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nha1 33 34
  • 45.88 (n)
Nha2 34
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F41E7.1 34
  • 23 (a)
ManyToMany
F57G8.5 34
  • 23 (a)
ManyToMany
F41E7.2 34
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6614 34
  • 51 (a)
OneToMany
Species where no ortholog for SLC9B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC9B2 Gene

ENSEMBL:
Gene Tree for SLC9B2 (if available)
TreeFam:
Gene Tree for SLC9B2 (if available)

Paralogs for SLC9B2 Gene

Paralogs for SLC9B2 Gene

(4) SIMAP similar genes for SLC9B2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC9B2: view

Variants for SLC9B2 Gene

Sequence variations from dbSNP and Humsavar for SLC9B2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000013799 -- 103,032,222(+) TCTAG(A/T)TATGC intron-variant
rs1000122566 -- 103,019,760(+) CGTTT(A/G)AGTGA upstream-variant-2KB, utr-variant-3-prime
rs1000292997 -- 103,039,700(+) TGGAG(C/T)GCAAT intron-variant
rs1000453183 -- 103,055,961(+) ACCAC(A/G)CCTGA intron-variant
rs1000501906 -- 103,071,181(+) ATTTG(-/AT)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC9B2 Gene

Variant ID Type Subtype PubMed ID
esv2759270 CNV gain 17122850
nsv4445 CNV insertion 18451855
nsv4446 CNV insertion 18451855
nsv461598 CNV loss 19166990
nsv594978 CNV loss 21841781
nsv830021 CNV loss 17160897

Variation tolerance for SLC9B2 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.60; 82.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC9B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC9B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC9B2 Gene

Disorders for SLC9B2 Gene

Relevant External Links for SLC9B2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC9B2

No disorders were found for SLC9B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC9B2 Gene

Publications for SLC9B2 Gene

  1. Dissecting the proton transport pathway in electrogenic Na+/H+ antiporters. (PMID: 28154142) Uzdavinys P … Drew D (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 4 60
  2. ++ (PMID: 28071645) Landreh M … Robinson CV (Nature communications 2017) 3 4 60
  3. Unconventional chemiosmotic coupling of NHA2, a mammalian Na+/H+ antiporter, to a plasma membrane H+ gradient. (PMID: 22948142) Kondapalli KC … Rao R (The Journal of biological chemistry 2012) 3 4 60
  4. Proteomic profile of osteoclast membrane proteins: identification of Na+/H+ exchanger domain containing 2 and its role in osteoclast fusion. (PMID: 18600791) Ha BG … Park EK (Proteomics 2008) 2 3 60
  5. Characterization of the sodium/hydrogen exchanger NHA2. (PMID: 18508966) Fuster DG … Moe OW (Journal of the American Society of Nephrology : JASN 2008) 3 4 60

Products for SLC9B2 Gene

Sources for SLC9B2 Gene

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