Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC9B2 Gene

protein-coding   GIFtS: 48
GCID: GC04M103946

Solute Carrier Family 9, Subfamily B (NHA2, Cation Proton...

(Previous names: Na+/H+ exchanger domain containing 2, solute carrier family...)
(Previous symbol: NHEDC2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 9, Subfamily B (NHA2, Cation Proton Antiporter
2), Member 21 2
     Solute Carrier Family 9 Subfamily B Member 22 3
NHEDC21 2 3 5     Na(+)/H(+) Exchanger-Like Domain-Containing Protein 22 3
NHA22 3 5     NHE Domain-Containing Protein 22 3
Na+/H+ Exchanger Domain Containing 21 2     NHE102
Solute Carrier Family 9, Subfamily B (Cation Proton Antiporter 2), Member
21 2
     Mitochondrial Sodium/Hydrogen Exchanger 9B22
Mitochondrial Na(+)/H(+) Exchanger NHA22 3     Mitochondrial Sodium/Hydrogen Exchanger NHA22
Sodium/Hydrogen Exchanger-Like Domain-Containing Protein 22 3     

External Ids:    HGNC: 251431   Entrez Gene: 1333082   Ensembl: ENSG000001640387   OMIM: 6117895   UniProtKB: Q86UD53   

Export aliases for SLC9B2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SLC9B2 Gene:
Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain
or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce
environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 (PubMed
18000046)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLC9B2 Gene:
SLC9B2 (solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2) is a protein-coding gene. Diseases associated with SLC9B2 include alcohol dependence, and essential hypertension. GO annotations related to this gene include solute:hydrogen antiporter activity. An important paralog of this gene is SLC9B1P1.

UniProtKB/Swiss-Prot: SL9B2_HUMAN, Q86UD5
Function: Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane.
Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption
activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SLC9B2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC9B2 promoter sequence
   Search Chromatin IP Primers for SLC9B2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC9B2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q24   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q24

SLC9B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC9B2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M103946:  view genomic region     (about GC identifiers)

Start:
103,941,025 bp from pter      End:
104,006,986 bp from pter
Size:
65,962 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SL9B2_HUMAN, Q86UD5 (See protein sequence)
Recommended Name: Mitochondrial sodium/hydrogen exchanger 9B2  
Size: 537 amino acids; 57564 Da
Secondary accessions: B5ME52 Q6ZMD8 Q96D95
Alternative splicing: 2 isoforms:  Q86UD5-1   Q86UD5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC9B2: NX_Q86UD5

Explore proteomics data for SLC9B2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC9B2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_849155.2  
    ENSEMBL proteins: 
     ENSP00000354574   ENSP00000421943   ENSP00000378265   ENSP00000425385   ENSP00000422477  
     ENSP00000426305   ENSP00000423496   ENSP00000345241  
    Reactome Protein details: Q86UD5

    SLC9B2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SLC9B2
    GenScript Custom Purified and Recombinant Proteins Services for SLC9B2
    Novus Biologicals SLC9B2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SLC9B2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC9B2
    Novus Biologicals SLC9B2 Antibodies
    Abcam antibodies for SLC9B2
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for SLC9B2
    LSBio Antibodies in human, mouse, rat for SLC9B2

    SLC9B2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC9B2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC9B2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers

    1 InterPro protein domain:
     IPR006153 Cation/H_exchanger

    Graphical View of Domain Structure for InterPro Entry Q86UD5

    ProtoNet protein and cluster: Q86UD5

    1 Blocks protein domain: IPB006153 Sodium/hydrogen exchanger

    UniProtKB/Swiss-Prot: SL9B2_HUMAN, Q86UD5
    Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family


    SLC9B2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SL9B2_HUMAN, Q86UD5
    Function: Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane.
    Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption
    activity (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015299solute:hydrogen antiporter activity IEA--
    GO:0016491oxidoreductase activity ----
         
    SLC9B2 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc9b2):
     endocrine/exocrine gland  homeostasis/metabolism  skeleton 

    SLC9B2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc9b2tm1.1Dgfu for SLC9B2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC9B2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC9B2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC9B2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC9B2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SLC9B2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SLC9B2
    SwitchGear 3'UTR luciferase reporter plasmidSLC9B2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC9B2
    Predesigned siRNA for gene silencing in human, mouse, rat SLC9B2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC9B2

    Clone
    Products:
         
    OriGene clones in human, mouse for SLC9B2 (see all 7)
    OriGene ORF clones in mouse, rat for SLC9B2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SLC9B2
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC9B2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9B2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC9B2
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC9B2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9B2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SL9B2_HUMAN, Q86UD5: Mitochondrion membrane; Multi-pass membrane protein (By similarity)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005743mitochondrial inner membrane TAS--
    GO:0016021integral component of membrane IEA--

    SLC9B2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SLC9B2 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC9B2
        Stimuli-sensing channels



    SLC9B2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC9B2
    Interactions:

        Search GeneGlobe Interaction Network for SLC9B2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for SLC9B2 (Q86UD53 ENSP000003545744) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTU2Q2VPK53I2D: score=5 
    DENND6BQ8NEG73I2D: score=5 
    RTFDC1Q9BY423I2D: score=5 
    CACTINQ8WUQ73I2D: score=4 
    BRAPENSP000003308134STRING: ENSP00000330813
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport ----
    GO:0006814sodium ion transport IEA--
    GO:0034220ion transmembrane transport TAS--
    GO:0055085transmembrane transport TAS--

    SLC9B2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC9B2 (SL9B2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLC9B2 gene: 
    NM_178833.4  

    Unigene Cluster for SLC9B2:

    Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
    Hs.546482  [show with all ESTs]
    Unigene Representative Sequence: BX640844
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000362026(uc010iln.2) ENST00000506288 ENST00000394785(uc003hwx.4 uc003hwy.3 uc011cew.2)
    ENST00000503103 ENST00000503230 ENST00000510976 ENST00000515424(uc011cey.2)
    ENST00000503818 ENST00000505838 ENST00000508136 ENST00000512806 ENST00000339611(uc011cex.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC9B2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SLC9B2
    SwitchGear 3'UTR luciferase reporter plasmidSLC9B2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC9B2
    Predesigned siRNA for gene silencing in human, mouse, rat SLC9B2
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC9B2 (see all 7)
    OriGene ORF clones in mouse, rat for SLC9B2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SLC9B2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC9B2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9B2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC9B2
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC9B2
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SLC9B2
      QuantiTect SYBR Green Assays in human, mouse, rat SLC9B2
      QuantiFast Probe-based Assays in human, mouse, rat SLC9B2

    Additional mRNA sequence: 

    AK172823.1 AK297010.1 AK298506.1 AK299888.1 BC009732.1 BC047447.1 BX640844.1 

    15 DOTS entries:

    DT.407073  DT.100679223  DT.40285522  DT.100712987  DT.95368440  DT.100775719  DT.405763  DT.91646431 
    DT.100664442  DT.121253271  DT.97793914  DT.70102815  DT.92417724  DT.91720702  DT.92007695 

    Selected AceView cDNA sequences (see all 115):

    BF724498 BI914487 F10816 BC009732 AA233152 BM702572 BM669493 BX454520 
    BX640844 BX359761 Z40158 BX381078 AA233228 BF724499 AI239938 BI962996 
    AI367621 BQ286748 BM971864 BM834042 BM683318 BX494716 BC047447 CA774595 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC9B2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
    SP1:                                                  -                       -     -                       -         
    SP2:                                                  -                       -     -                                 
    SP3:                                                  -                       -     -           -     -     -         
    SP4:                                                                          -                                       
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for SLC9B2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLC9B2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGAAAAAAA
    SLC9B2 Expression
    About this image


    SLC9B2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Stylopod Long Bone
     
     Liver (Hepatobiliary System)
    SLC9B2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC9B2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.546482

    UniProtKB/Swiss-Prot: SL9B2_HUMAN, Q86UD5
    Tissue specificity: Detected in red blood cells (at protein level)

        Custom PCR Arrays for SLC9B2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC9B2
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC9B2
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SLC9B2
    QuantiTect SYBR Green Assays in human, mouse, rat SLC9B2
    QuantiFast Probe-based Assays in human, mouse, rat SLC9B2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9B2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SLC9B2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc9b21 , 5 Na+/H+ exchanger domain containing 25
    solute carrier family 9, subfamily B (NHA2, cation more1
    81.9(n)1
    81.34(a)1
      3 (62.55 cM)5
    970861  NM_178877.61  NP_849208.41 
     1353077005 
    chicken
    (Gallus gallus)
    Aves NHEDC21 Na+/H+ exchanger domain containing 2 69.06(n)
    68.11(a)
      428776  XM_004935972.1  XP_004936029.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc9b21 solute carrier family 9, subfamily B (NHA2, cation more 68.2(n)
    67.47(a)
      100101762  NM_001100259.1  NP_001093729.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-162b23.41 si:dkey-162b23.4 62.31(n)
    66.3(a)
      571064  XM_694618.3  XP_699710.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nha11 Na[+]/H[+] hydrogen antiporter 1 45.88(n)
    35.86(a)
      33961  NM_135236.2  NP_609080.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F57G8.56
    F41E7.16
    (see all 3)
    Protein F41E7.1 (F41E7.1) mRNA, complete cds
    (see all 3)
    23(a)
    23(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    V(16339024-16341534) WBGene00010214
    X(10279599-10282845) WBGene00009617


    ENSEMBL Gene Tree for SLC9B2 (if available)
    TreeFam Gene Tree for SLC9B2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLC9B2 gene
    SLC9B1P12  SLC9B12  
    4 SIMAP similar genes for SLC9B2 using alignment to 5 protein entries:     SL9B2_HUMAN (see all proteins):
    BDH2    SLC9B1    SLC9B1P1    HSD17B14

    SLC9B2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SLC9B2 (see all 901)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1473708101,2
    --103946230(+) TAGGAA/GTGTGA 1 -- int10--------
    rs1848985761,2
    --103946280(+) GATATC/GATCAA 1 -- int10--------
    rs1394714141,2
    --103946330(+) CATCAC/TTTCCT 1 -- int10--------
    rs1899098651,2
    --103946385(+) GGAGAC/TATGGT 1 -- int10--------
    rs1838395881,2
    --103946394(+) GTAGAC/GATCCA 1 -- int10--------
    rs729435121,2
    C--103946619(+) GAGTAT/ACCCTG 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1144946691,2
    F--103946635(+) ATTAAC/TGAACC 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1152314561,2
    C,F--103946872(+) GCCACT/AGAAAT 1 -- ut311Minor allele frequency- A:0.05WA 118
    rs1494463431,2
    --103946914(+) GATAAA/GGTTTT 1 -- ut310--------
    rs768428101,2
    F--103947024(+) AGTAAC/GGGAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC9B2 (103941025 - 104006986 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SLC9B2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4445CNV Insertion18451855
    nsv4446CNV Insertion18451855
    nsv830021CNV Loss17160897
    nsv461598CNV Loss19166990
    dgv1656e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC9B2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC9B2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611789    OMIM disorders: --

    4 diseases for SLC9B2:    
    About MalaCards
    alcohol dependence    essential hypertension    hypertension    malaria


    SLC9B2 for disorders           About GeneDecksing


    Export disorders for SLC9B2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLC9B2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with SLC9B2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Proteomic profile of osteoclast membrane proteins: identification of Na+/H+ exchanger domain containing 2 and its role in osteoclast fusion. (PubMed id 18600791)1, 3 Ha B.G....Park E.K. (Proteomics 2008)
    2. A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension. (PubMed id 18000046)1, 2 Xiang M.... Rao R. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    3. Unconventional chemiosmotic coupling of NHA2, a mammalian Na+/H+ antiporter, to a plasma membrane H+ gradient. (PubMed id 22948142)1 Kondapalli K.C....Rao R. (J. Biol. Chem. 2012)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    6. Mutational analysis of NHAoc/NHA2 in Saccharomyces cerevisiae. (PubMed id 20713131)1 Huang X....Battaglino R.A. (Biochim. Biophys. Acta 2010)
    7. Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension. (PubMed id 20053353)1 Schushan M....Ben-Tal N. (J. Mol. Biol. 2010)
    8. NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts. (PubMed id 17988971)1 Battaglino R.A....Stashenko P. (Bone 2008)
    9. Characterization of the sodium/hydrogen exchanger NHA2. (PubMed id 18508966)1 Fuster D.G....Moe O.W. (J. Am. Soc. Nephrol. 2008)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 133308 HGNC: 25143 AceView: LOC150159 Ensembl:ENSG00000164038 euGenes: HUgn133308
    ECgene: SLC9B2 H-InvDB: SLC9B2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC9B2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLC9B2 gene:
    Search GeneIP for patents involving SLC9B2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for SLC9B2 (NHA2/SLC9B2)   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC9B2  
     OriGene qPCR primer pairs and template standards for SLC9B2   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC9B2  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC9B2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC9B2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC9B2   OriGene Custom Protein Services for SLC9B2  

     
     
     Block miRNA regulation of human, mouse, rat SLC9B2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC9B2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC9B2 Predesigned siRNA for gene silencing in human, mouse, rat SLC9B2
     QuantiFast Probe-based Assays in human, mouse, rat SLC9B2 QuantiTect SYBR Green Assays in human, mouse, rat SLC9B2
     Custom PCR Arrays for SLC9B2 Search Chromatin IP Primers for SLC9B2
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SLC9B2 Search GeneGlobe Interaction Network for SLC9B2
     Search Regulatory tfbs for SLC9B2
     GenScript Custom Purified and Recombinant Proteins Services for SLC9B2 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for SLC9B2
     GenScript Custom Assay Services for SLC9B2 GenScript Custom overexpressing Cell Line Services for SLC9B2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLC9B2 (SL9B2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLC9B2 antibodies
     SLC9B2 lysates
     Antibodies for SLC9B2
     See all of Abcam's Antibodies, Kits and Proteins for SLC9B2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC9B2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9B2
     SwitchGear 3'UTR luciferase reporter plasmids for SLC9B2
     SwitchGear Promoter luciferase reporter plasmids for SLC9B2
     Search ThermoFisher Antibodies for SLC9B2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9B2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC9B2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC9B2
     LSBio Antibodies in human, mouse, rat for SLC9B2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC9B2 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4