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Aliases for SLC9B1 Gene

Aliases for SLC9B1 Gene

  • Solute Carrier Family 9 Member B1 2 3
  • Solute Carrier Family 9, Subfamily B (NHA1, Cation Proton Antiporter 1), Member 1 2 3 5
  • Solute Carrier Family 9, Subfamily B (Cation Proton Antiporter 2), Member 1 2 3
  • Sodium/Hydrogen Exchanger-Like Domain-Containing Protein 1 3 4
  • Na(+)/H(+) Exchanger-Like Domain-Containing Protein 1 3 4
  • NHE Domain-Containing Protein 1 3 4
  • NHEDC1 3 4
  • Solute Carrier Family 9 Subfamily B Member 1 4
  • Na+/H+ Exchanger Domain Containing 1 2
  • Testicular Tissue Protein Li 127 3
  • NHA1 3

External Ids for SLC9B1 Gene

Previous HGNC Symbols for SLC9B1 Gene

  • NHEDC1

Previous GeneCards Identifiers for SLC9B1 Gene

  • GC04M103808

Summaries for SLC9B1 Gene

Entrez Gene Summary for SLC9B1 Gene

  • The protein encoded by this gene is a sodium/hydrogen exchanger and transmembrane protein. Highly conserved orthologs of this gene have been found in other mammalian species. The expression of this gene may be limited to testis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for SLC9B1 Gene

SLC9B1 (Solute Carrier Family 9 Member B1) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include solute:proton antiporter activity. An important paralog of this gene is SLC9B2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC9B1 Gene

Genomics for SLC9B1 Gene

Regulatory Elements for SLC9B1 Gene

Enhancers for SLC9B1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC9B1 on UCSC Golden Path with GeneCards custom track

Promoters for SLC9B1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC9B1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC9B1 Gene

102,885,048 bp from pter
103,019,739 bp from pter
134,692 bases
Minus strand

Genomic View for SLC9B1 Gene

Genes around SLC9B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC9B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC9B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC9B1 Gene

Proteins for SLC9B1 Gene

  • Protein details for SLC9B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/hydrogen exchanger 9B1
    Protein Accession:
    Secondary Accessions:
    • A1KXV1
    • B9EH04
    • C9JBP7
    • Q49A30
    • Q8NCV2
    • Q8WVZ0

    Protein attributes for SLC9B1 Gene

    515 amino acids
    Molecular mass:
    56054 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAM22868.1; Type=Frameshift; Positions=219, 298, 381; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC9B1 Gene


neXtProt entry for SLC9B1 Gene

Proteomics data for SLC9B1 Gene at MOPED

Post-translational modifications for SLC9B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC9B1 Gene

Domains & Families for SLC9B1 Gene

Gene Families for SLC9B1 Gene

Protein Domains for SLC9B1 Gene

Suggested Antigen Peptide Sequences for SLC9B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
genes like me logo Genes that share domains with SLC9B1: view

Function for SLC9B1 Gene

Gene Ontology (GO) - Molecular Function for SLC9B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015299 solute:proton antiporter activity IEA --
genes like me logo Genes that share ontologies with SLC9B1: view

Phenotypes for SLC9B1 Gene

GenomeRNAi human phenotypes for SLC9B1:
genes like me logo Genes that share phenotypes with SLC9B1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC9B1

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC9B1 Gene

Localization for SLC9B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC9B1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC9B1 Gene COMPARTMENTS Subcellular localization image for SLC9B1 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 2
peroxisome 2
endoplasmic reticulum 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SLC9B1 Gene

Pathways & Interactions for SLC9B1 Gene

genes like me logo Genes that share pathways with SLC9B1: view

Pathways by source for SLC9B1 Gene

Interacting Proteins for SLC9B1 Gene

Gene Ontology (GO) - Biological Process for SLC9B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport IEA --
GO:0035725 sodium ion transmembrane transport TAS --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC9B1: view

No data available for SIGNOR curated interactions for SLC9B1 Gene

Drugs & Compounds for SLC9B1 Gene

No Compound Related Data Available

Transcripts for SLC9B1 Gene

Unigene Clusters for SLC9B1 Gene

Solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC9B1 Gene

No ASD Table

Relevant External Links for SLC9B1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC9B1 Gene

mRNA expression in normal human tissues for SLC9B1 Gene

mRNA differential expression in normal tissues according to GTEx for SLC9B1 Gene

This gene is overexpressed in Testis (x28.1).

Protein differential expression in normal tissues from HIPED for SLC9B1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC9B1 Gene

SOURCE GeneReport for Unigene cluster for SLC9B1 Gene Hs.666728

mRNA Expression by UniProt/SwissProt for SLC9B1 Gene

Tissue specificity: Expressed only in the testis.
genes like me logo Genes that share expression patterns with SLC9B1: view

Protein tissue co-expression partners for SLC9B1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC9B1 Gene

Orthologs for SLC9B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC9B1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia SLC9B1 35
  • 82.65 (n)
  • 70.14 (a)
-- 36
  • 71 (a)
(Mus musculus)
Mammalia Slc9b1 35
  • 74.37 (n)
  • 66.21 (a)
Slc9b1 16
Slc9b1 36
  • 58 (a)
(Pan troglodytes)
Mammalia NHEDC1 35
  • 99.35 (n)
  • 99.03 (a)
SLC9B1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc9b1 35
  • 75.3 (n)
  • 65.94 (a)
(Bos Taurus)
Mammalia NHEDC1 36
  • 67 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
(Gallus gallus)
Aves -- 36
  • 50 (a)
(Danio rerio)
Actinopterygii CU695013.3 36
  • 36 (a)
si:dkey-162b23.4 36
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nha1 36
  • 23 (a)
Nha2 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea CELE_F57G8.5 35
  • 44.8 (n)
  • 30.4 (a)
F41E7.1 36
  • 24 (a)
F41E7.2 36
  • 20 (a)
F57G8.5 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6614 36
  • 43 (a)
Species with no ortholog for SLC9B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC9B1 Gene

Gene Tree for SLC9B1 (if available)
Gene Tree for SLC9B1 (if available)

Paralogs for SLC9B1 Gene

Paralogs for SLC9B1 Gene

(2) SIMAP similar genes for SLC9B1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC9B1: view

Variants for SLC9B1 Gene

Sequence variations from dbSNP and Humsavar for SLC9B1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs2715591 - 102,989,912(+) TCTTC(A/C)TGTGC intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs724446 -- 103,010,206(-) gaact(A/G)tgaga intron-variant
rs724447 -- 103,010,149(-) acagc(A/G)tacaa intron-variant
rs1383733 -- 102,995,297(-) CTGCA(A/G)TACTG intron-variant
rs2086499 -- 103,008,672(+) gacat(C/T)gcacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC9B1 Gene

Variant ID Type Subtype PubMed ID
dgv1655e1 CNV Complex 17122850
dgv1656e1 CNV Complex 17122850
nsv879683 CNV Loss 21882294
nsv528680 CNV Loss 19592680
nsv461598 CNV Loss 19166990
esv2678594 CNV Deletion 23128226
nsv10542 CNV Loss 18304495
esv2670006 CNV Deletion 23128226
nsv508300 CNV Loss 20534489
esv2588063 CNV Deletion 19546169
esv988357 CNV Deletion 20482838
nsv513156 CNV Loss 21212237
nsv436415 CNV Deletion 17901297
esv2178050 CNV Deletion 18987734
esv2728081 CNV Deletion 23290073
esv1026728 CNV Deletion 17803354
nsv879684 CNV Loss 21882294
nsv4445 CNV Insertion 18451855
nsv830021 CNV Loss 17160897

Variation tolerance for SLC9B1 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC9B1 Gene

Disorders for SLC9B1 Gene

Relevant External Links for SLC9B1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC9B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC9B1 Gene

Publications for SLC9B1 Gene

  1. Cloning of a novel human NHEDC1 (Na+/H+ exchanger like domain containing 1) gene expressed specifically in testis. (PMID: 16850186) Ye G.M. … Yu L. (Mol. Biol. Rep. 2006) 2 3 4 67
  2. Identification and characterization of methylation-dependent/independent DNA regulatory elements in the human SLC9B1 gene. (PMID: 25701605) Kumar P.L. … James P.F. (Gene 2015) 3
  3. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLC9B1 Gene

Sources for SLC9B1 Gene