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Aliases for SLC9B1 Gene

Aliases for SLC9B1 Gene

  • Solute Carrier Family 9, Subfamily B (NHA1, Cation Proton Antiporter 1), Member 1 2 3
  • NHEDC1 3 4 6
  • Solute Carrier Family 9, Subfamily B (Cation Proton Antiporter 2), Member 1 2 3
  • Sodium/Hydrogen Exchanger-Like Domain-Containing Protein 1 3 4
  • Na(+)/H(+) Exchanger-Like Domain-Containing Protein 1 3 4
  • NHE Domain-Containing Protein 1 3 4
  • Solute Carrier Family 9 Subfamily B Member 1 4
  • Na+/H+ Exchanger Domain Containing 1 2
  • Sodium/Hydrogen Exchanger 9B1 3
  • NHA1 3

External Ids for SLC9B1 Gene

Previous HGNC Symbols for SLC9B1 Gene

  • NHEDC1

Previous GeneCards Identifiers for SLC9B1 Gene

  • GC04M103808

Summaries for SLC9B1 Gene

Entrez Gene Summary for SLC9B1 Gene

  • The protein encoded by this gene is a sodium/hydrogen exchanger and transmembrane protein. Highly conserved orthologs of this gene have been found in other mammalian species. The expression of this gene may be limited to testis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for SLC9B1 Gene

SLC9B1 (Solute Carrier Family 9, Subfamily B (NHA1, Cation Proton Antiporter 1), Member 1) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include solute:proton antiporter activity. An important paralog of this gene is SLC9B2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC9B1 Gene

Genomics for SLC9B1 Gene

Genomic Location for SLC9B1 Gene

102,885,048 bp from pter
103,020,187 bp from pter
135,140 bases
Minus strand

Genomic View for SLC9B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC9B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC9B1 Gene

No data available for Regulatory Elements for SLC9B1 Gene

Proteins for SLC9B1 Gene

  • Protein details for SLC9B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/hydrogen exchanger 9B1
    Protein Accession:
    Secondary Accessions:
    • A1KXV1
    • B9EH04
    • C9JBP7
    • Q49A30
    • Q8NCV2
    • Q8WVZ0

    Protein attributes for SLC9B1 Gene

    515 amino acids
    Molecular mass:
    56054 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAM22868.1; Type=Frameshift; Positions=219, 298, 381; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC9B1 Gene


neXtProt entry for SLC9B1 Gene

Proteomics data for SLC9B1 Gene at MOPED

Post-translational modifications for SLC9B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC9B1 Gene

No data available for DME Specific Peptides for SLC9B1 Gene

Domains for SLC9B1 Gene

Gene Families for SLC9B1 Gene

  • SLC :Solute carriers

Protein Domains for SLC9B1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q4ZJI4
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
genes like me logo Genes that share domains with SLC9B1: view

No data available for Suggested Antigen Peptide Sequences for SLC9B1 Gene

Function for SLC9B1 Gene

Gene Ontology (GO) - Molecular Function for SLC9B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015299 solute:proton antiporter activity IEA --
genes like me logo Genes that share ontologies with SLC9B1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC9B1 Gene

Localization for SLC9B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC9B1 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SLC9B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC9B1: view

No data available for Subcellular locations from COMPARTMENTS for SLC9B1 Gene

Pathways for SLC9B1 Gene

genes like me logo Genes that share pathways with SLC9B1: view

Pathways by source for SLC9B1 Gene

Interacting Proteins for SLC9B1 Gene

Gene Ontology (GO) - Biological Process for SLC9B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport --
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC9B1: view

Transcripts for SLC9B1 Gene

Unigene Clusters for SLC9B1 Gene

Solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC9B1 Gene

No ASD Table

Relevant External Links for SLC9B1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC9B1 Gene

mRNA expression in normal human tissues for SLC9B1 Gene

mRNA differential expression in normal tissues according to GTEx for SLC9B1 Gene

This gene is overexpressed in Testis (28.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC9B1 Gene

SOURCE GeneReport for Unigene cluster for SLC9B1 Gene Hs.666728

mRNA Expression by UniProt/SwissProt for SLC9B1 Gene

Tissue specificity: Expressed only in the testis.
genes like me logo Genes that share expressions with SLC9B1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC9B1 Gene

Orthologs for SLC9B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC9B1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NHEDC1 35
  • 99.35 (n)
  • 99.03 (a)
SLC9B1 36
  • 99 (a)
(Bos Taurus)
Mammalia NHEDC1 36
  • 67 (a)
(Canis familiaris)
Mammalia -- 36
  • 71 (a)
SLC9B1 35
  • 82.65 (n)
  • 70.14 (a)
(Mus musculus)
Mammalia Slc9b1 35
  • 74.37 (n)
  • 66.21 (a)
Slc9b1 16
Slc9b1 36
  • 58 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
(Rattus norvegicus)
Mammalia Slc9b1 35
  • 75.3 (n)
  • 65.94 (a)
(Gallus gallus)
Aves -- 36
  • 50 (a)
(Danio rerio)
Actinopterygii CU695013.3 36
  • 36 (a)
si:dkey-162b23.4 36
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nha1 36
  • 23 (a)
Nha2 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea CELE_F57G8.5 35
  • 44.8 (n)
  • 30.4 (a)
F41E7.1 36
  • 24 (a)
F41E7.2 36
  • 20 (a)
F57G8.5 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6614 36
  • 43 (a)
Species with no ortholog for SLC9B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC9B1 Gene

Gene Tree for SLC9B1 (if available)
Gene Tree for SLC9B1 (if available)

Paralogs for SLC9B1 Gene

Paralogs for SLC9B1 Gene

Selected SIMAP similar genes for SLC9B1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC9B1: view

Variants for SLC9B1 Gene

Sequence variations from dbSNP and Humsavar for SLC9B1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs724446 -- 103,010,206(-) gaact(A/G)tgaga intron-variant
rs724447 -- 103,010,149(-) acagc(A/G)tacaa intron-variant
rs1383733 -- 102,995,297(-) CTGCA(A/G)TACTG intron-variant
rs2086499 -- 103,008,672(+) gacat(C/T)gcacc intron-variant
rs2219949 -- 103,011,627(+) GTGAC(C/T)TCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC9B1 Gene

Variant ID Type Subtype PubMed ID
dgv1655e1 CNV Complex 17122850
dgv1656e1 CNV Complex 17122850
nsv879683 CNV Loss 21882294
nsv528680 CNV Loss 19592680
nsv461598 CNV Loss 19166990
esv2678594 CNV Deletion 23128226
nsv10542 CNV Loss 18304495
esv2670006 CNV Deletion 23128226
nsv508300 CNV Loss 20534489
esv2588063 CNV Deletion 19546169
esv988357 CNV Deletion 20482838
nsv513156 CNV Loss 21212237
nsv436415 CNV Deletion 17901297
esv2178050 CNV Deletion 18987734
esv2728081 CNV Deletion 23290073
esv1026728 CNV Deletion 17803354
nsv879684 CNV Loss 21882294
nsv4445 CNV Insertion 18451855
nsv830021 CNV Loss 17160897

Relevant External Links for SLC9B1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC9B1 Gene

Disorders for SLC9B1 Gene

No disorders were found for SLC9B1 Gene.

No data available for UniProtKB/Swiss-Prot for SLC9B1 Gene

Publications for SLC9B1 Gene

  1. Cloning of a novel human NHEDC1 (Na+/H+ exchanger like domain containing 1) gene expressed specifically in testis. (PMID: 16850186) Ye G.M. … Yu L. (Mol. Biol. Rep. 2006) 2 3 4
  2. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLC9B1 Gene

Sources for SLC9B1 Gene

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