Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC9A9 Gene

protein-coding GIFtS: 52
GCID: GC03M142984

solute carrier family 9, subfamily A (NHE9, cation proton...

(Previous names: solute carrier family 9 (sodium/hydrogen exchanger), isoform...)

Explore 12 diseases affiliated with
SLC9A9 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 9, Subfamily A (NHE9, Cation Proton Antiporter 9), Member 9¹ ²		Putative Protein Product Of Nbla00118²
NHE9¹ ² ³		Sodium/Hydrogen Exchanger 9²
Na(+)/H(+) Exchanger 9² ³		Sodium/Proton Exchanger NHE9²
AUTS16² ⁵		Solute Carrier Family 9 (Sodium/Hydrogen Exchanger)²
FLJ35613¹		NHE-9³
Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 9¹		Solute Carrier Family 9 Member 9³
Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 9¹

External Ids:	HGNC: 20653¹	Entrez Gene: 285195²	Ensembl: ENSG00000181804⁷	OMIM: 608396⁵	UniProtKB: Q8IVB4³

Export aliases for SLC9A9 gene to outside databases

Previous GC identifers: GC00U907058 GC03M144304 GC03M144466 GC03M140356

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC9A9:

This gene encodes a sodium/proton exchanger that is a member of the solute carrier 9 protein family. The encoded

protein localizes the to the late recycling endosomes and may play an important role in maintaining cation

homeostasis. Mutations in this gene are associated with autism susceptibility 16 and attention-deficit/hyperactivity

disorder. (provided by RefSeq, Mar 2012)

UniProtKB/Swiss-Prot: SL9A9_HUMAN, Q8IVB4

Function: May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi

luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the

maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC9A9 gene promoter:
AML1a MEF-2 Tal-1beta LCR-F1 MEF-2A AREB6 aMEF-2 ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC9A9 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC9A9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC9A9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24 Ensembl cytogenetic band: 3q24 HGNC cytogenetic band: 3q23-q24

SLC9A9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC9A9 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M142984: view genomic region (about GC identifiers)

Start:	142,984,064 bp from pter	End:	143,567,373 bp from pter
Size:	583,310 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SL9A9_HUMAN, Q8IVB4 (See protein sequence)

Recommended Name: Sodium/hydrogen exchanger 9

Size: 645 amino acids; 72565 Da

Subcellular location: Late endosome membrane; Multi-pass membrane protein

Sequence caution: Sequence=BAC04005.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: A6NMQ9 Q3LIC2 Q5JPI6 Q5WA58 Q8NAB9

Explore the universe of human proteins at neXtProt for SLC9A9: NX_Q8IVB4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IVB4

SLC9A9 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_775924.1

ENSEMBL proteins:

ENSP00000320246 ENSP00000419090 ENSP00000418627

Reactome Protein details: Q8IVB4
Human Recombinant Protein Products for SLC9A9:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for SLC9A9
	GenScript Custom Purified and Recombinant Proteins Services for SLC9A9
	Novus Biologicals SLC9A9 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLC9A9

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--
GO:0031902	late endosome membrane	TAS	--
GO:0055037	recycling endosome	IDA	15522866

SLC9A9 for ontologies About GeneDecksing

SLC9A9 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SLC9A9
	GenScript Custom Superior Antibodies Services for SLC9A9
	Novus Biologicals SLC9A9 Antibodies
	Abcam antibodies for SLC9A9
	Uscn Antibodies for SLC9A9
	ThermoFisher Antibody for SLC9A9

Assay Products for SLC9A9:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SLC9A9
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SLC9A9

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC9A9 for domains About GeneDecksing

4 InterPro domains/families:

IPR018422 Cation/H_exchanger_CPA1

IPR004709 NaH_exchanger

IPR002090 Na/H_exchanger_6

IPR006153 Cation/H_exchanger

Graphical View of Domain Structure for InterPro Entry Q8IVB4

ProtoNet protein and cluster: Q8IVB4

2 Blocks protein families:

IPB004709 Na+/H+ exchanger signature

IPB006153 Sodium/hydrogen exchanger

UniProtKB/Swiss-Prot: SL9A9_HUMAN, Q8IVB4

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SL9A9_HUMAN, Q8IVB4

Function: May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi

luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the

maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015385	sodium:hydrogen antiporter activity	IEA	--

SLC9A9 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC9A9

miRNA Products:		OriGene 3'-UTR Clone: SLC9A9 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC9A9
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC9A9 (see all 26):
		hsa-miR-448 hsa-miR-3607-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3159 hsa-let-7g hsa-miR-124

		SwitchGear 3'UTR luciferase reporter plasmid: SLC9A9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC9A9 (see all 4) OriGene shRNA RFP: SLC9A9 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC9A9
		Sirion Biotech Custom design and validation of potent shRNA sequences against SLC9A9

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SLC9A9
			Sirion Biotech Customized adenovirus for overexpression of SLC9A9 Sirion Biotech Customized adenovirus for potent knockdown of SLC9A9

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A9 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A9 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SLC9A9 (NM_173653)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC9A9
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9A9

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SLC9A9
		Search LifeMap BioReagents cell lines for SLC9A9
		Sirion Biotech Customized stable knockdown cell line services for SLC9A9 Sirion Biotech Customized inducible knockdown cell line services for SLC9A9 Sirion Biotech Customized stable overexpressing cell line services for SLC9A9 Sirion Biotech Customized inducible overexpressing cell line services for SLC9A9

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A9

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

SLC-mediated transmembrane transport

SLC-mediated transmembrane transport

1.00

Transmembrane transport of small molecules

0.50

Sodium/Proton exchangers

Sodium/Proton exchangers

1.00

Amino acid and oligopeptide SLC transporters

Transport of inorganic cations/anions and amino acids/oligopeptides

0.52

Sweet Taste Signaling

Sperm Motility

0.36

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SLC9A9

Sperm Motility

4 Reactome Pathways for SLC9A9

	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Sodium/Proton exchangers
	Transport of inorganic cations/anions and amino acids/oligopeptides

SLC9A9 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC9A9

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	TAS	--
GO:0006885	regulation of pH	IEA	--
GO:0055085	transmembrane transport	TAS	--

SLC9A9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC9A9
Search CenterWatch for drugs/clinical trials and news about SLC9A9 / SL9A9

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC9A9 gene:

NM_173653.3

Unigene Cluster for SLC9A9:

Solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9

Hs.302257 [show with all ESTs]

Unigene Representative Sequence: NM_173653

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000316549(uc003evn.3 uc011bnk.2) ENST00000483124 ENST00000474727

ENST00000474151 ENST00000498717

miRNA Products:		OriGene 3'-UTR Clone: SLC9A9 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC9A9
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC9A9 (see all 26):
		hsa-miR-448 hsa-miR-3607-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3159 hsa-let-7g hsa-miR-124

		SwitchGear 3'UTR luciferase reporter plasmid: SLC9A9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC9A9 (see all 4) OriGene shRNA RFP: SLC9A9 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC9A9
		Sirion Biotech Custom design and validation of potent shRNA sequences against SLC9A9

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A9 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A9 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SLC9A9 (NM_173653)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC9A9
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9A9

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC9A9 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SLC9A9
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC9A9
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC9A9

Additional cDNA sequence:

AB075486.1 AB089794.1 AK092932.1 AK301816.1 AK315107.1 AL832304.1 AY254100.1 BC035779.1

5 DOTS entries:

DT.413692 DT.430374 DT.100747445 DT.40114404 DT.95297623

24/94 AceView cDNA sequences (see all 94):

AX747812 AA099385 AI276742 BM716984 AA055463 BX119727 AA436249 AA055462

AW592423 BF059422 BI063276 AA831374 BM682750 BI063369 BM055293 BM715633

BM142542 AI252807 BC035779 AY254100 AI167320 W74429 NM_173653 BM673853

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC9A9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGTTTTCTA

About this image

SLC9A9 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC9A9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC9A9

SOURCE GeneReport for Unigene cluster: Hs.302257

UniProtKB/Swiss-Prot: SL9A9_HUMAN, Q8IVB4

Tissue specificity: Ubiquitously expressed in all tissues tested. Expressed at highest levels in heart and skeletal

muscle, followed by placenta, kidney, and liver. Expressed in the brain, in the medulla and spinal cord

SABiosciences Custom PCR Arrays for SLC9A9

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC9A9 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SLC9A9
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC9A9
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC9A9

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A9

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SLC9A9 gene from 7/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC9A9¹	solute carrier family 9 (sodium/hydrogen exchanger), more	77.2(n) 82.16(a)		424772 NM_001031305.1 NP_001026476.1
lizard (Anolis carolinensis)	Reptilia	SLC9A9⁶	--	87(a)	1 ↔ 1	3(21054817-21280014)
fruit fly (Drosophila melanogaster)	Insecta	Nhe3⁶	Na[+]/H[+] hydrogen exchanger 3	40(a)	1 → many	2L(6677835-6684364)
worm (Caenorhabditis elegans)	Secernentea	nhx-5⁶	Na/H eXchanger family member (nhx-5)	36(a)	1 → many	X(10576898-10580992)
thale cress (Arabidopsis thaliana)	eudicotyledons	NHX5⁶ ATNHX6⁶	sodium/hydrogen exchanger 6	32(a) 30(a)	many ↔ many many ↔ many	1(20293151-20297133) 1(29952873-29957189)
rice (Oryza sativa)	Liliopsida	Os.5237²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	73.28(n)		AK072114.1
E. coli (Escherichia coli)	Gamma proteobacteria	yjcE⁶	predicted cation/proton antiporter	12(a)	1 → many	Chromosome(4278003-4279652)

ENSEMBL Gene Tree for SLC9A9 (if available)
TreeFam Gene Tree for SLC9A9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC9A9 gene

SLC9A6² SLC9A8² SLC9A3² SLC9A1² SLC9A5² SLC9A2² SLC9A4² SLC9A7²

3 SIMAP similar genes for SLC9A9 using alignment to 4 protein entries: SL9A9_HUMAN (see all proteins):

SLC9A7 SLC9A6 SLC9A8

SLC9A9 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148124512^1,2	C	unknown	242347064(+)	`TTCCCA/GAACAC`	1	--	int¹		0	--	--	--	--
rs121912597^1,2	C	other	242274071(-)	`TAGGCC/TGAAAA`	2	R *	stg¹		0	--	--	--	--
rs73867299^1,2	C	--	140356066(+)	`GGGACG/TCCTCC`	1	--	ds500¹		1		WA	2
rs16853287^1,2	C,F,H	--	140356459(+)	`CCACCA/GCAGTG`	1	--	ut3¹ ese³		25		NA NS EA WA	3032
rs73867300^1,2	C	--	140356505(+)	`AAGCAC/TACATT`	1	--	ut3¹		1		WA	2
rs80091738^1,2		--	140356508(+)	`CATACA/GTTACT`	1	--	ut3¹		1		NA	120
rs76311785^1,2	C,F	--	140356939(+)	`CATATC/AGCGGG`	1	--	ut3¹		1		NA	120
rs199657721^1,2	C	--	140357663(-)	`GCTGGA/GAAACA`	1	--	ut3¹		0	--	--	--	--
rs75407673^1,2	F	--	140358137(+)	`GCATGG/ATACAG`	1	--	int¹		1		NA	120
rs16853295^1,2	C,F,H	--	140358250(+)	`TTTGGG/CTTAAG`	1	--	int¹		13		NA NS EA WA	1640

HapMap Linkage Disequilibrium report for SLC9A9 (142984064 - 143234064 bp, first 250kb of SLC9A9)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for SLC9A9
6 CNVs: 63610 91605 7368 3453 7369 98464
5 Indels: 27172 79942 33744 27171 27173
Human Gene Mutation Database (HGMD): SLC9A9

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC9A9

DNA2.0 Custom Variant and Variant Library Synthesis for SLC9A9

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC9A9 for disorders           About GeneDecksing

OMIM gene information: 608396
OMIM disorders: 613410
UniProtKB/Swiss-Prot: SL9A9_HUMAN, Q8IVB4

Note=A chromosomal aberration involving SLC9A9 has been found in a family with early-onset

behavioral/developmental disorder with features of attention deficit-hyperactivity disorder and intellectual

disability. Inversion inv(3)(p14:q21). The inversion disrupts DOCK3 and SLC9A9

Defects in SLC9A9 are a cause of susceptibility to autism type 16 (AUTS16) [MIM:613410]. Autism is a complex

multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and

communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental

abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. AUTS16 can be

associated with epilepsy

12 diseases for SLC9A9: About MalaCards

attention deficit hyperactivity disorder autism susceptibility 16 pervasive developmental disorder fatty liver disease

intellectual disability leptospirosis liver disease pneumonia

neuroblastoma tuberculosis neuronitis mycobacterium tuberculosis

1 disease from the University of Copenhagen DISEASES database for SLC9A9:

Leptospirosis

Human Genome Epidemiology (HuGE) Navigator: SLC9A9 (8 documents)

Export disorders for SLC9A9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLC9A9 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with SLC9A9)

Utopia: connect your pdf to the dynamic
world of online information

Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype. (PubMed id 14569117)^{1, 2, 3} De Silva M.G.... Forrest S. (2003)
Four Na+/H+ exchanger isoforms are distributed to Golgi and post- Golgi Compartments and are involved in organelle pH regulation. (PubMed id 15522866)^{1, 2} Nakamura N.... Kanazawa H. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker. (PubMed id 22566498)¹ Turner S.T....Boerwinkle E. (2012)
Polymorphisms in B3GAT1, SLC9A9 and MGAT5 are associat ed with variation within the human plasma N-glycome of 3533 European adults. (PubMed id 21908519)¹ Huffman J.E....Lauc G. (2011)
SLC9A9 mutations, gene expression, and protein-protein interactions in rat models of attention-deficit/hyperactivity disorder. (PubMed id 21858920)¹ Zhang-James Y....Faraone S.V. (2011)
The BTB and CNC homology 1 (BACH1) target genes are i nvolved in the oxidative stress response and in control of the cell cycle. (PubMed id 21555518)¹ Warnatz H.J....Yaspo M.L. (2011)
Organellar Na+/H+ exchangers: novel players in organe lle pH regulation and their emerging functions. (PubMed id 21171650)¹ Ohgaki R....Kanazawa H. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 285195	HGNC: 20653	AceView: SLC9A9	Ensembl:ENSG00000181804	euGenes: HUgn285195
ECgene: SLC9A9	H-InvDB: SLC9A9

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLC9A9	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC9A9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SLC9A9 gene:
Search GeneIP for patents involving SLC9A9

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for SLC9A9
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC9A9		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC9A9
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	Browse OriGene siRNAs		OriGene 3'-UTR Clone for SLC9A9
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A9		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A9
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SLC9A9		OriGene Custom Protein Services for SLC9A9
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC9A9
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC9A9
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC9A9
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC9A9
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC9A9
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC9A9

	GenScript Custom Purified and Recombinant Proteins Services for SLC9A9		GenScript cDNA clones with any tag delivered in your preferred vector for SLC9A9
	GenScript Custom Assay Services for SLC9A9		GenScript Custom Superior Antibodies Services for SLC9A9
	GenScript Custom overexpressing Cell Line Services for SLC9A9		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SLC9A9 promoter
	Search Chromatin IP Primers for SLC9A9
	RT² qPCR Primer Assay in human, mouse, rat SLC9A9
	Search GNC Networks for SLC9A9
	SABiosciences PCR Arrays including human, mouse, rat SLC9A9

Search Tocris compounds for SLC9A9

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SLC9A9 antibodies
	SLC9A9 proteins

	Antibodies for SLC9A9
	See all of Abcam's Antibodies, Kits and Proteins for SLC9A9
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

SLC9A9 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SLC9A9

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A9

	SwitchGear 3'UTR luciferase reporter plasmids for SLC9A9
	SwitchGear Promoter luciferase reporter plasmids for SLC9A9

ThermoFisher Antibody for SLC9A9

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9A9

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC9A9

Sirion Biotech Customized:

	stable knockdown cell line services for SLC9A9
	inducible knockdown cell line services for SLC9A9
	design and validation of potent shRNA sequences against SLC9A9
	adenovirus for potent knockdown of SLC9A9
	adenovirus for overexpression of SLC9A9
	stable overexpressing cell line services for SLC9A9
	inducible overexpressing cell line services for SLC9A9

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SLC9A9 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

SLC9A9 Gene

solute carrier family 9, subfamily A (NHE9, cation proton...

Aliases
for SLC9A9 gene

Summaries
for SLC9A9 gene

Genomic Views
for SLC9A9 gene

Proteins
for SLC9A9 gene

Protein Domains /
Families
for SLC9A9 gene

Function
for SLC9A9 gene

Pathways & Interactions
for SLC9A9 gene

Drugs & Compounds
for SLC9A9 gene

Transcripts
for SLC9A9 gene

Expression
for SLC9A9 gene

Orthologs
for SLC9A9 gene

Paralogs
for SLC9A9 gene

Genomic Variants
for SLC9A9 gene

Disorders / Diseases
for SLC9A9 gene

Publications
for SLC9A9 gene

External Searches for SLC9A9 gene

Genome Databases showing SLC9A9 gene

Other Databases showing SLC9A9 gene

Specialized Databases showing SLC9A9 gene

Intellectual Property
for SLC9A9 gene

Products
for SLC9A9 gene

View Random Gene

Advanced Search

Export list of displayed genes

SLC9A9 Gene

solute carrier family 9, subfamily A (NHE9, cation proton...

Aliasesfor SLC9A9 gene

Summariesfor SLC9A9 gene

Genomic Viewsfor SLC9A9 gene

Proteinsfor SLC9A9 gene

Protein Domains /Familiesfor SLC9A9 gene

Functionfor SLC9A9 gene

Pathways & Interactionsfor SLC9A9 gene

Drugs & Compoundsfor SLC9A9 gene

Transcriptsfor SLC9A9 gene

Expression for SLC9A9 gene

Orthologsfor SLC9A9 gene

Paralogsfor SLC9A9 gene

Genomic Variantsfor SLC9A9 gene

Disorders / Diseasesfor SLC9A9 gene

Publicationsfor SLC9A9 gene

External Searches for SLC9A9 gene

Genome Databases showing SLC9A9 gene

Other Databases showing SLC9A9 gene

Specialized Databases showing SLC9A9 gene

Intellectual Propertyfor SLC9A9 gene

Productsfor SLC9A9 gene

View Random Gene

Aliases
for SLC9A9 gene

Summaries
for SLC9A9 gene

Genomic Views
for SLC9A9 gene

Proteins
for SLC9A9 gene

Protein Domains /
Families
for SLC9A9 gene

Function
for SLC9A9 gene

Pathways & Interactions
for SLC9A9 gene

Drugs & Compounds
for SLC9A9 gene

Transcripts
for SLC9A9 gene

Expression
for SLC9A9 gene

Orthologs
for SLC9A9 gene

Paralogs
for SLC9A9 gene

Genomic Variants
for SLC9A9 gene

Disorders / Diseases
for SLC9A9 gene

Publications
for SLC9A9 gene

Intellectual Property
for SLC9A9 gene

Products
for SLC9A9 gene