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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC9A8 Gene

protein-coding   GIFtS: 56
GCID: GC20P048429

Solute Carrier Family 9, Subfamily A (NHE8, Cation Proton...

(Previous names: solute carrier family 9 (sodium/hydrogen exchanger), isoform...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 9, Subfamily A (NHE8, Cation Proton Antiporter
8), Member 81 2
     KIAA09393 5
NHE82 3 5     Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 81
Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 81 2     Sodium/Hydrogen Exchanger 82
NHE-82 3     Solute Carrier Family 9 (Sodium/Hydrogen Exchanger)2
Na(+)/H(+) Exchanger 82 3     Solute Carrier Family 9 Member 83

External Ids:    HGNC: 207281   Entrez Gene: 233152   Ensembl: ENSG000001978187   OMIM: 6127305   UniProtKB: Q9Y2E83   

Export aliases for SLC9A8 gene to outside databases

Previous GC identifers: GC20P048117 GC20P049067 GC20P049113 GC20P047862 GC20P045177


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC9A8 Gene:
Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular
Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume
regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 (PubMed 18209477)).(supplied by
OMIM, Apr 2009)

GeneCards Summary for SLC9A8 Gene: 
SLC9A8 (solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8) is a protein-coding gene. Diseases associated with SLC9A8 include renal tubular acidosis, and diarrhea, and among its related super-pathways are Transmembrane transport of small molecules and Amino acid and oligopeptide SLC transporters. GO annotations related to this gene include potassium:hydrogen antiporter activity and sodium:hydrogen antiporter activity. An important paralog of this gene is SLC9A3.

UniProtKB/Swiss-Prot: SL9A8_HUMAN, Q9Y2E8
Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse
environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays
an important role in signal transduction

Gene Wiki entry for SLC9A8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC9A8 gene promoter:
         Elk-1   p53   LCR-F1   Evi-1   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC9A8 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC9A8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC9A8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.13   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.13

SLC9A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC9A8 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P048429:  view genomic region     (about GC identifiers)

Start:
48,429,250 bp from pter      End:
48,508,779 bp from pter
Size:
79,530 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SL9A8_HUMAN, Q9Y2E8 (See protein sequence)
Recommended Name: Sodium/hydrogen exchanger 8  
Size: 581 amino acids; 65422 Da
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAA76783.2; Type=Erroneous initiation;
Secondary accessions: B4DTQ8 Q2M1U9 Q68CZ8 Q9BX15 Q9Y507
Alternative splicing: 2 isoforms:  Q9Y2E8-1   Q9Y2E8-2   

Explore the universe of human proteins at neXtProt for SLC9A8: NX_Q9Y2E8

Explore proteomics data for SLC9A8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2E8

  • SLC9A8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC9A8 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001247420.1  NP_056081.1  

    ENSEMBL proteins: 
     ENSP00000354966   ENSP00000416418   ENSP00000441716   ENSP00000441615  
    Reactome Protein details: Q9Y2E8
    Human Recombinant Protein Products for SLC9A8: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus ----
    GO:0016021integral to membrane IEA--

    SLC9A8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Sodium/hydrogen exchanger 8 
    SLC9 family of sodium/hydrogen exchangers

    4 InterPro protein domains:
     IPR018422 Cation/H_exchanger_CPA1
     IPR004709 NaH_exchanger
     IPR018409 Na/H_exchanger_8_eu
     IPR006153 Cation/H_exchanger

    Graphical View of Domain Structure for InterPro Entry Q9Y2E8

    ProtoNet protein and cluster: Q9Y2E8

    2 Blocks protein domains:
    IPB004709 Na+/H+ exchanger signature
    IPB006153 Sodium/hydrogen exchanger


    UniProtKB/Swiss-Prot: SL9A8_HUMAN, Q9Y2E8
    Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family


    SLC9A8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SL9A8_HUMAN, Q9Y2E8
    Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse
    environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays
    an important role in signal transduction

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015299solute:hydrogen antiporter activity ----
    GO:0015385sodium:hydrogen antiporter activity IEA--
    GO:0015386potassium:hydrogen antiporter activity IEA--
         
    SLC9A8 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc9a8):
     digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism  pigmentation  reproductive system 
     vision/eye 

    SLC9A8 for phenotypes           About GeneDecksing

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC9A8 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC9A8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50
    2Amino acid and oligopeptide SLC transporters
    Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    3Sodium/Proton exchangers
    Sodium/Proton exchangers

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for SLC9A8
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Sodium/Proton exchangers
    Transport of inorganic cations/anions and amino acids/oligopeptides



    SLC9A8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC9A8

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for SLC9A8 (Q9Y2E83 ENSP000003549664) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    IFT88Q130993I2D: score=3 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006812cation transport ----
    GO:0006813potassium ion transport ----
    GO:0006814sodium ion transport ----
    GO:0006885regulation of pH ----

    SLC9A8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC9A8 (SL9A8)

    1 HMDB Compound for SLC9A8    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    Search CenterWatch for drugs/clinical trials and news about SLC9A8 / SL9A8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC9A8 gene (2 alternative transcripts): 
    NM_001260491.1  NM_015266.2  

    Unigene Cluster for SLC9A8:

    Solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
    Hs.444202  [show with all ESTs]
    Unigene Representative Sequence: NM_001260491
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361573(uc010gid.3) ENST00000489787 ENST00000490250 ENST00000417961(uc010zyj.1 uc010zyk.1 uc010zyl.1 uc010gib.1 uc002xuv.1 uc010zym.1)
    ENST00000539601 ENST00000541138(uc010gic.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    hsa-miR-642a hsa-miR-15a hsa-miR-486-3p hsa-miR-30d hsa-miR-548m hsa-miR-424 hsa-miR-30a hsa-miR-149
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: 

    AB023156.2 AK124491.1 AK131001.1 AK295665.1 AK295803.1 AK295822.1 AK300318.1 AK308328.1 
    AK310530.1 AL049469.1 AL833574.1 BC112213.1 CR749638.1 NR_048537.1 NR_048538.1 NR_048539.1 
    NR_048540.1 

    12 DOTS entries:

    DT.444379  DT.100750169  DT.100750170  DT.120824509  DT.40276718  DT.120824458  DT.40244405  DT.40246670 
    DT.437158  DT.91920780  DT.91973255  DT.95102480 

    24/126 AceView cDNA sequences (see all 126):

    AI867168 AW139838 CA489825 BF058768 F12096 BF222481 AW270137 AA732658 
    F09734 AA350796 AL049469 C00664 AI497848 CA430878 AI970804 AA961790 
    BG236352 CK904093 AA704611 R11655 AB023156 BX484804 AL833574 BQ447187 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC9A8    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b
    SP1:                                -                       -                                                           -                     
    SP2:                                -                                                                                                         
    SP3:                                -           -           -     -                                                                           
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for SLC9A8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC9A8 expression in normal human tissues (normalized intensities)      SLC9A8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGAGCCCC
    SLC9A8 Expression
    About this image


    SLC9A8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             retinal progenitor cell e12.5   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Neural Tube (Nervous System)
             Telencephalon

    See SLC9A8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC9A8

    SOURCE GeneReport for Unigene cluster: Hs.444202

    UniProtKB/Swiss-Prot: SL9A8_HUMAN, Q9Y2E8
    Tissue specificity: Ubiquitous. Strongly expressed in skeletal muscle and kidney

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC9A8 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc9a81 , 5 solute carrier family 9 (sodium/hydrogen exchanger), more1, 5 88.7(n)1
    96.7(a)1
      2 (87.22 cM)5
    770311  NM_148929.21  NP_683731.11 
     1674217125 
    chicken
    (Gallus gallus)
    Aves SLC9A81 solute carrier family 9 (sodium/hydrogen exchanger), more 81.2(n)
    93.17(a)
      419356  NM_001039275.1  NP_001034364.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC9A86
    solute carrier family 9, subfamily A (NHE8, cation...
    92(a)
    1 ↔ 1
    4(147065875-147143448)
    zebrafish
    (Danio rerio)
    Actinopterygii wufj61b022 Transcribed sequence with weak similarity to protein more 80.43(n)    CK236692.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nhe11 Na[+]/H[+] hydrogen exchanger 1 57.96(n)
    58.27(a)
      33167  NM_134647.3  NP_608491.3 
    worm
    (Caenorhabditis elegans)
    Secernentea nhx-81 Protein NHX-8 53(n)
    48.2(a)
      189474  NM_001026558.1  NP_001021729.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NHX16
    Na+/H+ and K+/H+ exchanger, required for intracell...
    23(a)
    1 → many
    IV(1367485-1369386)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NHX61 sodium/hydrogen exchanger 6 46.37(n)
    38.68(a)
      844299  NM_106609.3  NP_178079.2 
    rice
    (Oryza sativa)
    Liliopsida Os09g02864001 hypothetical protein 47.47(n)
    38.88(a)
      4346626  NM_001069315.1  NP_001062780.1 


    ENSEMBL Gene Tree for SLC9A8 (if available)
    TreeFam Gene Tree for SLC9A8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC9A8 gene
    SLC9A32  SLC9A62  SLC9A42  SLC9A12  SLC9A92  SLC9A52  SLC9A22  SLC9A72  
    3 SIMAP similar genes for SLC9A8 using alignment to 3 protein entries:     SL9A8_HUMAN (see all proteins):
    SLC9A6    SLC9A9    SLC9A3

    SLC9A8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1786 SNPs in SLC9A8 are shown (see all 1786)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs15762071,2
    C,F--48427348(+) ATTCCC/TGCCAG 6 -- us2k112Minor allele frequency- T:0.42NA WA CSA EA 510
    rs1176546951,2
    C,F--48427355(+) CCAGGC/TTCTGT 6 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1425299401,2
    C--48427366(+) GCTAAC/TGGAGG 6 -- us2k10--------
    rs1505876651,2
    --48427438(+) CTACTA/GGTTTA 6 -- us2k10--------
    rs60910511,2
    A--48427462(+) tgtgcC/Ttgaat 6 -- us2k10--------
    rs1168641881,2
    F--48427568(+) AAAGAA/GTTAAG 6 -- us2k11Minor allele frequency- G:0.01EA 120
    rs1867182811,2
    --48427635(+) TAAACA/GTTGGT 6 -- us2k10--------
    rs1912103981,2
    --48427765(+) CACCAC/TGCTTA 6 -- us2k10--------
    rs1807012241,2
    --48427785(+) TTATAC/TGCCAT 6 -- us2k10--------
    rs349885221,2
    C,F--48427796(+) AGTCCG/ATCAGC 6 -- us2k17Minor allele frequency- A:0.16NA WA EA 366

    HapMap Linkage Disequilibrium report for SLC9A8 (48429250 - 48508779 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SLC9A8:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2722491CNV Deletion23290073
    esv2722490CNV Deletion23290073
    esv2722489CNV Deletion23290073
    nsv912915CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC9A8
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC9A8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612730    OMIM disorders: --

    4 diseases for SLC9A8:    About MalaCards
    renal tubular acidosis    diarrhea    pneumonia    tuberculosis


    SLC9A8 for disorders           About GeneDecksing


    Export disorders for SLC9A8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC9A8 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with SLC9A8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Four Na+/H+ exchanger isoforms are distributed to Golgi and post- Golgi Compartments and are involved in organelle pH regulation. (PubMed id 15522866)1, 2 Nakamura N.... Kanazawa H. (2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Renal expression of novel Na+/H+ exchanger isoform NHE8. (PubMed id 12409279)1, 3 Goyal S....Aronson P.S. (2003)
    4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
    7. Organellar Na+/H+ exchangers: novel players in organe lle pH regulation and their emerging functions. (PubMed id 21171650)1 Ohgaki R....Kanazawa H. (2011)
    8. Nucleotide sequence of the Na+/H+ exchanger-8 in patie nts with congenital sodium diarrhea. (PubMed id 21666503)1 Baum M....Moe O. (2011)
    9. Genome-wide association analysis identifies three pso riasis susceptibility loci. (PubMed id 20953189)1 Stuart P.E....Elder J.T. (2010)
    10. Epidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription. (PubMed id 20375273)1 Xu H....Ghishan F.K. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23315 HGNC: 20728 AceView: SLC9A8 Ensembl:ENSG00000197818 euGenes: HUgn23315
    ECgene: SLC9A8 H-InvDB: SLC9A8

    (According to HUGE)
    About This Section
    HUGE: KIAA0939

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC9A8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC9A8 gene:
    Search GeneIP for patents involving SLC9A8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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