Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC9A8 Gene

protein-coding   GIFtS: 55
GCID: GC20P048429

Solute Carrier Family 9, Subfamily A (NHE8, Cation Proton...

(Previous names: solute carrier family 9 (sodium/hydrogen exchanger), isoform...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 9, Subfamily A (NHE8, Cation Proton Antiporter
8), Member 81 2
     KIAA09393 5
NHE82 3 5     Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 81
Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 81 2     Sodium/Hydrogen Exchanger 82
NHE-82 3     Solute Carrier Family 9 (Sodium/Hydrogen Exchanger)2
Na(+)/H(+) Exchanger 82 3     Solute Carrier Family 9 Member 83

External Ids:    HGNC: 207281   Entrez Gene: 233152   Ensembl: ENSG000001978187   OMIM: 6127305   UniProtKB: Q9Y2E83   

Export aliases for SLC9A8 gene to outside databases

Previous GC identifers: GC20P048117 GC20P049067 GC20P049113 GC20P047862 GC20P045177


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SLC9A8 Gene:
Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular
Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume
regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 (PubMed 18209477)).(supplied by
OMIM, Apr 2009)

GeneCards Summary for SLC9A8 Gene:
SLC9A8 (solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8) is a protein-coding gene. Diseases associated with SLC9A8 include renal tubular acidosis, and diarrhea. GO annotations related to this gene include potassium:hydrogen antiporter activity and sodium:hydrogen antiporter activity. An important paralog of this gene is SLC9A3.

UniProtKB/Swiss-Prot: SL9A8_HUMAN, Q9Y2E8
Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse
environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays
an important role in signal transduction

Gene Wiki entry for SLC9A8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC9A8 gene promoter:
         Elk-1   p53   LCR-F1   Evi-1   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC9A8 promoter sequence
   Search Chromatin IP Primers for SLC9A8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC9A8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.13   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.13

SLC9A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC9A8 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P048429:  view genomic region     (about GC identifiers)

Start:
48,429,250 bp from pter      End:
48,508,779 bp from pter
Size:
79,530 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SL9A8_HUMAN, Q9Y2E8 (See protein sequence)
Recommended Name: Sodium/hydrogen exchanger 8  
Size: 581 amino acids; 65422 Da
Sequence caution: Sequence=BAA76783.2; Type=Erroneous initiation;
Secondary accessions: B4DTQ8 Q2M1U9 Q68CZ8 Q9BX15 Q9Y507
Alternative splicing: 2 isoforms:  Q9Y2E8-1   Q9Y2E8-2   

Explore the universe of human proteins at neXtProt for SLC9A8: NX_Q9Y2E8

Explore proteomics data for SLC9A8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC9A8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001247420.1  NP_056081.1  

    ENSEMBL proteins: 
     ENSP00000354966   ENSP00000416418   ENSP00000441716   ENSP00000441615  
    Reactome Protein details: Q9Y2E8

    SLC9A8 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SLC9A8
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SLC9A8
    GenScript Custom Purified and Recombinant Proteins Services for SLC9A8
    Novus Biologicals SLC9A8 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SLC9A8 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SLC9A8
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SLC9A8
    OriGene Custom Antibody Services for SLC9A8
    Novus Biologicals SLC9A8 Antibodies
    Abcam antibodies for SLC9A8
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for SLC9A8
    LSBio Antibodies in human, mouse, rat for SLC9A8

    SLC9A8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC9A8
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC9A8
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Sodium/hydrogen exchanger 8
    SLC9 family of sodium/hydrogen exchangers

    4 InterPro protein domains:
     IPR018409 Na/H_exchanger_8_eu
     IPR006153 Cation/H_exchanger
     IPR018422 Cation/H_exchanger_CPA1
     IPR004709 NaH_exchanger

    Graphical View of Domain Structure for InterPro Entry Q9Y2E8

    ProtoNet protein and cluster: Q9Y2E8

    2 Blocks protein domains:
    IPB004709 Na+/H+ exchanger signature
    IPB006153 Sodium/hydrogen exchanger


    UniProtKB/Swiss-Prot: SL9A8_HUMAN, Q9Y2E8
    Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family


    SLC9A8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SL9A8_HUMAN, Q9Y2E8
    Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse
    environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays
    an important role in signal transduction

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015299solute:hydrogen antiporter activity ----
    GO:0015385sodium:hydrogen antiporter activity IEA--
    GO:0015386potassium:hydrogen antiporter activity IEA--
         
    SLC9A8 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc9a8):
     digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism  pigmentation  reproductive system 
     vision/eye 

    SLC9A8 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC9A8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC9A8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC9A8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC9A8

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SLC9A8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC9A8 (see all 33):
    hsa-miR-642a hsa-miR-15a hsa-miR-486-3p hsa-miR-30d hsa-miR-548m hsa-miR-424 hsa-miR-30a hsa-miR-149
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC9A8
    Predesigned siRNA for gene silencing in human, mouse, rat SLC9A8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC9A8

    Clone
    Products:
         
    OriGene clones in human, mouse for SLC9A8 (see all 7)
    OriGene ORF clones in mouse, rat for SLC9A8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC9A8 (NM_015266)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC9A8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9A8

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC9A8
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC9A8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SL9A8_HUMAN, Q9Y2E8: Golgi apparatus membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus ----
    GO:0016021integral component of membrane IEA--

    SLC9A8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SLC9A8 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Sodium/Proton exchangers0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC9A8
        Sodium/Proton exchangers



    SLC9A8 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC9A8
    Interactions:

        GeneGlobe Interaction Network for SLC9A8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for SLC9A8 (Q9Y2E83 ENSP000003549664) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    IFT88Q130993I2D: score=3 
    ARL1ENSP000002616364STRING: ENSP00000261636
    TMCO3ENSP000003893994STRING: ENSP00000389399
    CHMP6ENSP000003174684STRING: ENSP00000317468
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006812cation transport ----
    GO:0006813potassium ion transport ----
    GO:0006814sodium ion transport ----
    GO:0006885regulation of pH ----

    SLC9A8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC9A8 (SL9A8)

    1 HMDB Compound for SLC9A8    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLC9A8 gene (2 alternative transcripts): 
    NM_001260491.1  NM_015266.2  

    Unigene Cluster for SLC9A8:

    Solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
    Hs.444202  [show with all ESTs]
    Unigene Representative Sequence: NM_001260491
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361573(uc010gid.3) ENST00000489787 ENST00000490250 ENST00000417961(uc010zyj.1 uc010zyk.1 uc010zyl.1 uc010gib.1 uc002xuv.1 uc010zym.1)
    ENST00000539601 ENST00000541138(uc010gic.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC9A8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC9A8 (see all 33):
    hsa-miR-642a hsa-miR-15a hsa-miR-486-3p hsa-miR-30d hsa-miR-548m hsa-miR-424 hsa-miR-30a hsa-miR-149
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC9A8
    Predesigned siRNA for gene silencing in human, mouse, rat SLC9A8
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC9A8 (see all 7)
    OriGene ORF clones in mouse, rat for SLC9A8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC9A8 (NM_015266)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC9A8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9A8
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC9A8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC9A8
      QuantiTect SYBR Green Assays in human, mouse, rat SLC9A8
      QuantiFast Probe-based Assays in human, mouse, rat SLC9A8

    Additional mRNA sequence: 

    AB023156.2 AK124491.1 AK131001.1 AK295665.1 AK295803.1 AK295822.1 AK300318.1 AK308328.1 
    AK310530.1 AL049469.1 AL833574.1 BC112213.1 CR749638.1 NR_048537.1 NR_048538.1 NR_048539.1 
    NR_048540.1 

    12 DOTS entries:

    DT.444379  DT.100750169  DT.100750170  DT.120824509  DT.40276718  DT.120824458  DT.40244405  DT.40246670 
    DT.437158  DT.91920780  DT.91973255  DT.95102480 

    Selected AceView cDNA sequences (see all 126):

    AA350796 F12096 AI970804 AA704611 BE250610 AL049469 NM_015266 BG236352 
    CA430878 BM980622 BM988008 C00664 BF058768 F09734 BQ447187 AI497848 
    AI867168 BX484804 AA961790 AA350797 AA732658 AB023156 AL833574 AA213756 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC9A8    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b
    SP1:                                -                       -                                                           -                     
    SP2:                                -                                                                                                         
    SP3:                                -           -           -     -                                                                           
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for SLC9A8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLC9A8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGAGCCCC
    SLC9A8 Expression
    About this image


    SLC9A8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Eye (Sensory Organs)
             Retina
     
     Neural Tube (Nervous System)
             Telencephalon
    SLC9A8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC9A8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444202

    UniProtKB/Swiss-Prot: SL9A8_HUMAN, Q9Y2E8
    Tissue specificity: Ubiquitous. Strongly expressed in skeletal muscle and kidney

        Custom PCR Arrays for SLC9A8
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC9A8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC9A8
    QuantiTect SYBR Green Assays in human, mouse, rat SLC9A8
    QuantiFast Probe-based Assays in human, mouse, rat SLC9A8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC9A8 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc9a81 , 5 solute carrier family 9 (sodium/hydrogen exchanger), more1, 5 88.7(n)1
    96.7(a)1
      2 (87.22 cM)5
    770311  NM_148929.21  NP_683731.11 
     1674217125 
    chicken
    (Gallus gallus)
    Aves SLC9A81 solute carrier family 9, subfamily A (NHE8, cation more 81.24(n)
    93.21(a)
      419356  NM_001039275.2  NP_001034364.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC9A86
    solute carrier family 9, subfamily A (NHE8, cation...
    92(a)
    1 ↔ 1
    4(147065875-147143448)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc9a81 solute carrier family 9, subfamily A (NHE8, cation more 78.65(n)
    90.97(a)
      100216016  NM_001197262.1  NP_001184191.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj61b022 Transcribed sequence with weak similarity to protein more 80.43(n)    CK236692.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nhe11 Na[+]/H[+] hydrogen exchanger 1 58.08(n)
    58.46(a)
      33167  NM_134647.4  NP_608491.3 
    worm
    (Caenorhabditis elegans)
    Secernentea nhx-81 nhx-8 51.52(n)
    44.83(a)
      189474  NM_001026558.2  NP_001021729.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NHX16
    Na+/H+ and K+/H+ exchanger, required for intracell...
    24(a)
    1 → many
    IV(1367485-1369386) YDR456W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NHX61 NHX6 46.45(n)
    38.72(a)
      844299  NM_106609.3  NP_178079.2 
    rice
    (Oryza sativa)
    Liliopsida Os09g02864001 Os09g0286400 46.86(n)
    38.24(a)
      4346626  NM_001069315.1  NP_001062780.1 


    ENSEMBL Gene Tree for SLC9A8 (if available)
    TreeFam Gene Tree for SLC9A8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLC9A8 gene
    SLC9A32  SLC9A62  SLC9A12  SLC9A92  SLC9A52  SLC9A22  SLC9A72  SLC9A42  
    3 SIMAP similar genes for SLC9A8 using alignment to 3 protein entries:     SL9A8_HUMAN (see all proteins):
    SLC9A6    SLC9A9    SLC9A3

    SLC9A8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SLC9A8 (see all 1786)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs15762071,2
    C,F--48427348(+) ATTCCC/TGCCAG 6 -- us2k112Minor allele frequency- T:0.42NA WA CSA EA 510
    rs1176546951,2
    C,F--48427355(+) CCAGGC/TTCTGT 6 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1425299401,2
    C--48427366(+) GCTAAC/TGGAGG 6 -- us2k10--------
    rs1505876651,2
    --48427438(+) CTACTA/GGTTTA 6 -- us2k10--------
    rs60910511,2
    A--48427462(+) tgtgcC/Ttgaat 6 -- us2k10--------
    rs1168641881,2
    F--48427568(+) AAAGAA/GTTAAG 6 -- us2k11Minor allele frequency- G:0.01EA 120
    rs1867182811,2
    --48427635(+) TAAACA/GTTGGT 6 -- us2k10--------
    rs1912103981,2
    --48427765(+) CACCAC/TGCTTA 6 -- us2k10--------
    rs1807012241,2
    --48427785(+) TTATAC/TGCCAT 6 -- us2k10--------
    rs349885221,2
    C,F--48427796(+) AGTCCG/ATCAGC 6 -- us2k17Minor allele frequency- A:0.16NA WA EA 366

    HapMap Linkage Disequilibrium report for SLC9A8 (48429250 - 48508779 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SLC9A8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722491CNV Deletion23290073
    esv2722490CNV Deletion23290073
    esv2722489CNV Deletion23290073
    nsv912915CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC9A8
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC9A8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612730    OMIM disorders: --

    8 diseases for SLC9A8:    
    About MalaCards
    renal tubular acidosis    diarrhea    psoriasis    pneumonia
    tuberculosis    retinitis    cerebritis    malaria


    SLC9A8 for disorders           About GeneDecksing


    Export disorders for SLC9A8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLC9A8 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with SLC9A8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Four Na+/H+ exchanger isoforms are distributed to Golgi and post- Golgi Compartments and are involved in organelle pH regulation. (PubMed id 15522866)1, 2 Nakamura N.... Kanazawa H. (J. Biol. Chem. 2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Renal expression of novel Na+/H+ exchanger isoform NHE8. (PubMed id 12409279)1, 3 Goyal S....Aronson P.S. (Am. J. Physiol. Renal Physiol. 2003)
    4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    6. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    7. Organellar Na+/H+ exchangers: novel players in organelle pH regulation and their emerging functions. (PubMed id 21171650)1 Ohgaki R....Kanazawa H. (Biochemistry 2011)
    8. Nucleotide sequence of the Na+/H+ exchanger-8 in patients with congenital sodium diarrhea. (PubMed id 21666503)1 Baum M....Moe O. (J. Pediatr. Gastroenterol. Nutr. 2011)
    9. Genome-wide association analysis identifies three psoriasis susceptibility loci. (PubMed id 20953189)1 Stuart P.E....Elder J.T. (Nat. Genet. 2010)
    10. Epidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription. (PubMed id 20375273)1 Xu H....Ghishan F.K. (Am. J. Physiol., Cell Physiol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23315 HGNC: 20728 AceView: SLC9A8 Ensembl:ENSG00000197818 euGenes: HUgn23315
    ECgene: SLC9A8 H-InvDB: SLC9A8

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0939

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC9A8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLC9A8 gene:
    Search GeneIP for patents involving SLC9A8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SLC9A8
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SLC9A8   OriGene RNAi products in human, mouse, rat for SLC9A8  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SLC9A8  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC9A8  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC9A8   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC9A8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC9A8   OriGene Custom Protein Services for SLC9A8  

     
     
     Block miRNA regulation of human, mouse, rat SLC9A8 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC9A8
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC9A8 Predesigned siRNA for gene silencing in human, mouse, rat SLC9A8
     QuantiFast Probe-based Assays in human, mouse, rat SLC9A8 QuantiTect SYBR Green Assays in human, mouse, rat SLC9A8
     Custom PCR Arrays for SLC9A8 Search Chromatin IP Primers for SLC9A8
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC9A8  GeneGlobe Interaction Network for SLC9A8
     Regulatory tfbs in SLC9A8 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SLC9A8 GenScript cDNA clones with any tag delivered in your preferred vector for SLC9A8
     GenScript Custom Assay Services for SLC9A8 GenScript Custom overexpressing Cell Line Services for SLC9A8
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLC9A8 (SL9A8)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLC9A8 antibodies
     SLC9A8 lysates
     Antibodies for SLC9A8
     See all of Abcam's Antibodies, Kits and Proteins for SLC9A8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC9A8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A8
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SLC9A8
     SwitchGear Promoter luciferase reporter plasmids for SLC9A8
     ThermoFisher Antibodies for SLC9A8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9A8
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC9A8
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC9A8
     LSBio Antibodies in human, mouse, rat for SLC9A8
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC9A8 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4