SLC9A7 Gene
protein-coding GIFtS: 49
GCID: GC0XM046464
|
|
solute carrier family 9, subfamily A (NHE7, cation proton...(Previous names: solute carrier family 9 (sodium/hydrogen exchanger), isoform...)
| |
Aliases
for SLC9A7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 9, Subfamily A (NHE7, Cation Proton Antiporter 7),Member 71 2 | | SLC9A62 | | NHE71 2 3 5 | | Nonselective Sodium Potassium/Proton Exchanger2 | | NHE-72 3 | | Sodium/Hydrogen Exchanger 72 | | Na(+)/H(+) Exchanger 72 3 | | Solute Carrier Family 9 (Sodium/Hydrogen Exchanger)2 | | Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 71 | | Solute Carrier Family 9 Member 73 | | Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 71 | | |
Export aliases for SLC9A7 gene to outside databasesPrevious GC identifers: GC0XM045269 GC0XM044726 GC0XM045292 GC0XM045512 GC0XM046222 GC0XM046349 GC0XM044177 |
Summaries
for SLC9A7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC9A7:
This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 proteinfamily. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pHhomeostasis in organelles along the secretory and endocytic pathways. This protein may enhance cell growth of certainbreast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found onchromosome 12. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Mar 2012)
UniProtKB/Swiss-Prot: SL9A7_HUMAN, Q96T83Function: Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgivolume and cation homeostasis
|
Genomic Views
for SLC9A7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC9A7 gene promoter:
Nkx3-1 RFX1 Nkx3-1 v4 GATA-3 AML1a Nkx3-1 v1 Evi-1 Nkx3-1 v2 Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC9A7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC9A7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.3|Xp11.3 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.3SLC9A7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM046464: view genomic region
(about GC identifiers)
Start:
|
46,464,753 bp from pter |
End:
|
46,618,490 bp from pter |
Size:
|
153,738 bases |
Orientation:
|
minus strand |
|
Proteins
for SLC9A7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SL9A7_HUMAN, Q96T83 (See
protein sequence)Recommended Name: Sodium/hydrogen exchanger 7 Size: 725 amino acids; 80131 Da
Subunit: Interacts with SCAMP1, SCAMP2 and SCAMP5; may participate in its shuttling from trans-Golgi network torecycling endosomes
Subcellular location: Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosomemembrane; Multi-pass membrane protein
Miscellaneous: Is not inhibited by amiloride but by benzamil and quinine
Secondary accessions: O75827 Q5JXP9Explore the universe of human proteins at neXtProt for SLC9A7: NX_Q96T83
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96T83
SLC9A7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001244220.1 NP_115980.1
ENSEMBL proteins: ENSP00000330320 Reactome Protein details: Q96T83
Human Recombinant Protein Products for SLC9A7:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
SLC9A7 for ontologies About GeneDecksing
SLC9A7 Antibody Products:
Assay Products for SLC9A7: |
Protein
Domains /
Families
for SLC9A7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC9A7 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96T83ProtoNet protein and cluster: Q96T83 3 Blocks protein families: IPB002090 Na+/H+ exchanger isoform 6 (NHE6) signature IPB004709 Na+/H+ exchanger signature IPB006153 Sodium/hydrogen exchanger
UniProtKB/Swiss-Prot: SL9A7_HUMAN, Q96T83Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family |
Function
for SLC9A7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SL9A7_HUMAN, Q96T83Function: Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgivolume and cation homeostasis Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
SLC9A7 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for SLC9A7:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A7
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLC9A7 (NM_032591) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC9A7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9A7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A7 |
|
Pathways & Interactions
for SLC9A7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | SLC-mediated transmembrane transport | | | 2 | Sodium/Proton exchangers | | | 3 | Amino acid and oligopeptide SLC transporters | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for SLC9A7
SLC9A7 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC9A7
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5 Interacting proteins for SLC9A7 (Q96T833 ENSP000003303204) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
SLC9A7 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC9A7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC9A7
Search CenterWatch for drugs/clinical trials and news about SLC9A7 / SL9A7
|
Transcripts
for SLC9A7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC9A7 gene (2 alternative transcripts): NM_001257291.1 NM_032591.2 4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000328306(uc004dgu.1 uc004dgv.1) ENST00000464933 ENST00000491894
ENST00000489574
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A7 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A7
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC9A7 (NM_032591) | | | DNA2.0 Custom Codon Optimized Gene
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14 AceView cDNA sequences: NM_032591 AF298591 BF061440 AK056599 AA662537 BQ447812 AW297646 CF593538 BQ018779 W47116 AW817227 AA832156 W47115 BX112873
GeneLoc Exon Structure
|
Expression
for SLC9A7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC9A7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATATTCAGG
About this image
See SLC9A7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC9A7
UniProtKB/Swiss-Prot: SL9A7_HUMAN, Q96T83Tissue specificity: Ubiquitously expressed
SABiosciences Custom PCR Arrays for SLC9A7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC9A7
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A7 |
Orthologs
for SLC9A7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for SLC9A7 gene from 10/32 species (see all 32) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SLC9A71 |
solute carrier family 9 (sodium/hydrogen exchanger), more |
79.16(n)
89.34(a) |
|
418676 XM_416872.3 XP_416872.2 |
lizard
(Anolis carolinensis) |
Reptilia |
SLC9A76 |
-- |
88(a) |
1 ↔ 1 |
3(111957279-112009583) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
CF224746.12 |
-- |
79.27(n) |
|
CF224746.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
slc9a71 |
solute carrier family 9 (sodium/hydrogen exchanger), more |
72.98(n)
80.33(a) |
|
554532 NM_001030077.2 NP_001025248.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Nhe33 |
sodium:hydrogen antiporter |
49(a) |
|
26F6 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
nhx-51 |
Protein NHX-5 |
51.86(n)
44.08(a) |
|
181258 NM_001029549.1 NP_001024720.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
NHX11 |
Nhx1p |
48.85(n)
40.57(a) |
|
852066 NP_010744.3 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
NHX56ATNHX66 |
sodium/hydrogen exchanger 6 |
31(a)30(a) |
many ↔ manymany ↔ many |
1(20293151-20297133) 1(29952873-29957189) |
rice
(Oryza sativa) |
Liliopsida |
---- |
transporter, monovalent cation:proton antiporter-2...transporter, monovalent cation:proton antiporter-2... |
28(a)24(a) |
many ↔ manymany ↔ many |
9(18542825-18548133) 9(6372268-6382644) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
yjcE6 |
predicted cation/proton antiporter |
13(a) |
1 → many |
Chromosome(4278003-4279652) |
ENSEMBL Gene Tree for SLC9A7 (if available)
TreeFam Gene Tree for SLC9A7 (if available) |
Paralogs
for SLC9A7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC9A7 gene
- SLC9A62 SLC9A82 SLC9A32 SLC9A12 SLC9A92 SLC9A52 SLC9A22 SLC9A42
2 SIMAP similar genes for SLC9A7 using alignment to 1 protein entry: SL9A7_HUMAN:SLC9A6 SLC9A9
SLC9A7 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SLC9A7
PGOHUM00000261838
|
Genomic Variants
for SLC9A7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC9A7 (46464753 - 46618490 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC9A7: --
Locus Specific Mutation Databases (LSDB): SLC9A7
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC9A7 |
|
Disorders
/ Diseases
for SLC9A7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC9A7 for disorders About GeneDecksing
OMIM gene information: 300368
OMIM disorders: --
5  diseases for SLC9A7: About MalaCardsintellectual disability pneumonia tuberculosis neuronitis
mycobacterium tuberculosis
Export disorders for SLC9A7 gene to outside databases
|
Publications
for SLC9A7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC9A7 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with SLC9A7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network. (PubMed id 11279194)1, 2, 3, 9 Numata M. and Orlowski J. (2001)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7. (PubMed id 15840657)1, 2 Lin P.J.... Numata M. (2005)
- Identification and biochemical characterization of the SLC9A7 interactome. (PubMed id 18654930)1, 9 Kagami T....Numata M. (2008)
- A membrane-proximal region in the C-terminal tail of NHE7 is required for its distribution in the trans-Golgi network, distinct from NHE6 localization at endosomes. (PubMed id 20364249)1, 9 Fukura N....Kanazawa H. (2010)
- Organellar (Na+, K+)/H+ exchanger NHE7 regulates cell adhesion, invasion and anchorage-independent growth of breast cancer MDA-MB-231 cells. (PubMed id 22076128)1 Onishi I....Numata M. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Organellar Na+/H+ exchangers: novel players in organe lle pH regulation and their emerging functions. (PubMed id 21171650)1 Ohgaki R....Kanazawa H. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders. (PubMed id 11944989)1 Thiselton D.L.... Meindl A. (2002)
|
External Searches for SLC9A7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC9A7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC9A7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC9A7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC9A7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC9A7 gene:
Search GeneIP for patents involving SLC9A7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC9A7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A7 |
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