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Aliases for SLC9A7 Gene

Aliases for SLC9A7 Gene

  • Solute Carrier Family 9 Member A7 2 3 5
  • Solute Carrier Family 9, Subfamily A (NHE7, Cation Proton Antiporter 7), Member 7 2 3
  • Na(+)/H(+) Exchanger 7 3 4
  • NHE-7 3 4
  • NHE7 3 4
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 7 2
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 7 2
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger) 3
  • Nonselective Sodium Potassium/Proton Exchanger 3
  • Solute Carrier Family 9 Member 7 4
  • Sodium/Hydrogen Exchanger 7 3
  • SLC9A6 3

External Ids for SLC9A7 Gene

Previous GeneCards Identifiers for SLC9A7 Gene

  • GC0XM045269
  • GC0XM044726
  • GC0XM045292
  • GC0XM045512
  • GC0XM046222
  • GC0XM046349
  • GC0XM046464
  • GC0XM044177

Summaries for SLC9A7 Gene

Entrez Gene Summary for SLC9A7 Gene

  • This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. This protein may enhance cell growth of certain breast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found on chromosome 12. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

GeneCards Summary for SLC9A7 Gene

SLC9A7 (Solute Carrier Family 9 Member A7) is a Protein Coding gene. Diseases associated with SLC9A7 include Scapuloperoneal Myopathy. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include protein homodimerization activity and sodium:proton antiporter activity. An important paralog of this gene is SLC9A6.

UniProtKB/Swiss-Prot for SLC9A7 Gene

  • Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC9A7 Gene

Genomics for SLC9A7 Gene

Regulatory Elements for SLC9A7 Gene

Enhancers for SLC9A7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF046709 1.6 FANTOM5 Ensembl ENCODE 21.2 +46.9 46938 5.4 HDGF WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF121 GLIS2 ZNF207 SLC9A7 ENSG00000269902 LOC100420317 YBX1P8
GH0XF046626 1.5 FANTOM5 Ensembl ENCODE 19.5 +130.9 130872 4.6 PKNOX1 TBL1XR1 FEZF1 ZBTB40 SCRT2 ETV6 FOS CREM THAP11 USF2 CHST7 SLC9A7 RP2 ZNF674 PGAM1P7 PIR58897
GH0XF046756 0.9 ENCODE 22.9 +1.0 1048 4.1 PKNOX1 ZNF76 KLF17 ARID4B SIN3A ZNF2 RAD21 GLIS2 EGR1 ZNF143 SLC9A7 LOC100420317
GH0XF046572 1.3 FANTOM5 ENCODE 15.7 +184.9 184897 4.4 HDGF PKNOX1 TBL1XR1 WRNIP1 ARID4B SIN3A BRCA1 RAD21 GLIS2 ZNF366 CHST7 SLC9A7 RP2 ZNF674 PIR58897
GH0XF046586 1.2 Ensembl ENCODE 16.6 +170.8 170772 4.8 ELF3 HDAC1 ARID4B SIN3A ZBTB40 YY1 ZNF335 GLIS2 ELK1 ZNF143 SLC9A7 KRBOX4 CHST7 PIR58897
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC9A7 on UCSC Golden Path with GeneCards custom track

Promoters for SLC9A7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000478207 872 3001 PKNOX1 ZNF76 KLF17 ARID4B SIN3A ZNF2 RAD21 GLIS2 EGR1 ZNF143

Genomic Location for SLC9A7 Gene

Chromosome:
X
Start:
46,599,246 bp from pter
End:
46,759,172 bp from pter
Size:
159,927 bases
Orientation:
Minus strand

Genomic View for SLC9A7 Gene

Genes around SLC9A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC9A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC9A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC9A7 Gene

Proteins for SLC9A7 Gene

  • Protein details for SLC9A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T83-SL9A7_HUMAN
    Recommended name:
    Sodium/hydrogen exchanger 7
    Protein Accession:
    Q96T83
    Secondary Accessions:
    • O75827
    • Q5JXP9

    Protein attributes for SLC9A7 Gene

    Size:
    725 amino acids
    Molecular mass:
    80131 Da
    Quaternary structure:
    • Interacts with SCAMP1, SCAMP2 and SCAMP5; may participate in its shuttling from trans-Golgi network to recycling endosomes.
    Miscellaneous:
    • Is not inhibited by amiloride but by benzamil and quinine.

neXtProt entry for SLC9A7 Gene

Post-translational modifications for SLC9A7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC9A7 Gene

Domains & Families for SLC9A7 Gene

Gene Families for SLC9A7 Gene

Suggested Antigen Peptide Sequences for SLC9A7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96T83

UniProtKB/Swiss-Prot:

SL9A7_HUMAN :
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Family:
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
genes like me logo Genes that share domains with SLC9A7: view

Function for SLC9A7 Gene

Molecular function for SLC9A7 Gene

UniProtKB/Swiss-Prot Function:
Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis.

Gene Ontology (GO) - Molecular Function for SLC9A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15840657
GO:0015297 antiporter activity IEA --
GO:0015299 solute:proton antiporter activity IEA --
GO:0015385 sodium:proton antiporter activity IEA,TAS --
GO:0015386 potassium:proton antiporter activity IDA 11279194
genes like me logo Genes that share ontologies with SLC9A7: view
genes like me logo Genes that share phenotypes with SLC9A7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC9A7

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC9A7 Gene

Localization for SLC9A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC9A7 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC9A7 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 5
endosome 5
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SLC9A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005768 endosome IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005802 trans-Golgi network IDA 11279194
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with SLC9A7: view

Pathways & Interactions for SLC9A7 Gene

genes like me logo Genes that share pathways with SLC9A7: view

Gene Ontology (GO) - Biological Process for SLC9A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA,TAS --
GO:0006812 cation transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0006814 sodium ion transport IEA --
genes like me logo Genes that share ontologies with SLC9A7: view

No data available for SIGNOR curated interactions for SLC9A7 Gene

Transcripts for SLC9A7 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC9A7 Gene

No ASD Table

Relevant External Links for SLC9A7 Gene

GeneLoc Exon Structure for
SLC9A7
ECgene alternative splicing isoforms for
SLC9A7

Expression for SLC9A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC9A7 Gene

mRNA differential expression in normal tissues according to GTEx for SLC9A7 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for SLC9A7 Gene

This gene is overexpressed in Blymphocyte (23.0), Platelet (21.1), Retina (12.6), and Lung (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC9A7 Gene



Protein tissue co-expression partners for SLC9A7 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC9A7 Gene:

SLC9A7

mRNA Expression by UniProt/SwissProt for SLC9A7 Gene:

Q96T83-SL9A7_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with SLC9A7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC9A7 Gene

Orthologs for SLC9A7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC9A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC9A7 34 35
  • 97.79 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC9A7 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC9A7 34 35
  • 91.27 (n)
dog
(Canis familiaris)
Mammalia SLC9A7 34 35
  • 90.86 (n)
mouse
(Mus musculus)
Mammalia Slc9a7 34 16 35
  • 89.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC9A7 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC9A7 34 35
  • 78.23 (n)
lizard
(Anolis carolinensis)
Reptilia SLC9A7 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc9a7 34
  • 76.23 (n)
zebrafish
(Danio rerio)
Actinopterygii slc9a7 34 35
  • 73.29 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nhe3 36 35
  • 49 (a)
worm
(Caenorhabditis elegans)
Secernentea nhx-5 35
  • 41 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NHX1 35
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 56 (a)
OneToMany
Species where no ortholog for SLC9A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC9A7 Gene

ENSEMBL:
Gene Tree for SLC9A7 (if available)
TreeFam:
Gene Tree for SLC9A7 (if available)

Paralogs for SLC9A7 Gene

Paralogs for SLC9A7 Gene

(2) SIMAP similar genes for SLC9A7 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SLC9A7 Gene

genes like me logo Genes that share paralogs with SLC9A7: view

Variants for SLC9A7 Gene

Sequence variations from dbSNP and Humsavar for SLC9A7 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10046981 -- 46,704,690(+) GGAGT(A/G)GAGTA intron-variant
rs10217961 -- 46,669,134(+) CTGCA(C/T)TCCAG intron-variant
rs10442371 -- 46,737,995(+) gcact(C/G)tagcc intron-variant
rs10539010 -- 46,734,248(+) ACACA(-/CA)CACAC intron-variant
rs1056846 -- 46,758,886(+) TCCTC(C/G)GCCGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SLC9A7 Gene

Variant ID Type Subtype PubMed ID
nsv6885 CNV deletion 18451855
nsv6884 CNV insertion 18451855
nsv1147423 CNV duplication 26484159
nsv1078669 CNV duplication 25765185
esv3576853 CNV gain 25503493
dgv4235n106 CNV duplication 24896259

Variation tolerance for SLC9A7 Gene

Residual Variation Intolerance Score: 26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC9A7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC9A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC9A7 Gene

Disorders for SLC9A7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC9A7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
scapuloperoneal myopathy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC9A7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC9A7
genes like me logo Genes that share disorders with SLC9A7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC9A7 Gene

Publications for SLC9A7 Gene

  1. Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network. (PMID: 11279194) Numata M. … Orlowski J. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. A membrane-proximal region in the C-terminal tail of NHE7 is required for its distribution in the trans-Golgi network, distinct from NHE6 localization at endosomes. (PMID: 20364249) Fukura N. … Kanazawa H. (J. Membr. Biol. 2010) 3 22 64
  3. Identification and biochemical characterization of the SLC9A7 interactome. (PMID: 18654930) Kagami T. … Numata M. (Mol. Membr. Biol. 2008) 3 22 64
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  5. Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7. (PMID: 15840657) Lin P.J. … Numata M. (J. Cell Sci. 2005) 3 4 64

Products for SLC9A7 Gene

Sources for SLC9A7 Gene

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