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Aliases for SLC9A7 Gene

Aliases for SLC9A7 Gene

  • Solute Carrier Family 9, Subfamily A (NHE7, Cation Proton Antiporter 7), Member 7 2 3
  • NHE7 3 4 6
  • Na(+)/H(+) Exchanger 7 3 4
  • NHE-7 3 4
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 7 2
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 7 2
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger) 3
  • Nonselective Sodium Potassium/Proton Exchanger 3
  • Solute Carrier Family 9 Member 7 4
  • Sodium/Hydrogen Exchanger 7 3
  • SLC9A6 3

External Ids for SLC9A7 Gene

Previous GeneCards Identifiers for SLC9A7 Gene

  • GC0XM045269
  • GC0XM044726
  • GC0XM045292
  • GC0XM045512
  • GC0XM046222
  • GC0XM046349
  • GC0XM046464
  • GC0XM044177

Summaries for SLC9A7 Gene

Entrez Gene Summary for SLC9A7 Gene

  • This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. This protein may enhance cell growth of certain breast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found on chromosome 12. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

GeneCards Summary for SLC9A7 Gene

SLC9A7 (Solute Carrier Family 9, Subfamily A (NHE7, Cation Proton Antiporter 7), Member 7) is a Protein Coding gene. Among its related pathways are CREB Pathway and TCR Signaling (Qiagen). GO annotations related to this gene include protein homodimerization activity and potassium:proton antiporter activity. An important paralog of this gene is SLC9A4.

UniProtKB/Swiss-Prot for SLC9A7 Gene

  • Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC9A7 Gene

Genomics for SLC9A7 Gene

Regulatory Elements for SLC9A7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC9A7 Gene

46,599,251 bp from pter
46,759,172 bp from pter
159,922 bases
Minus strand

Genomic View for SLC9A7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC9A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC9A7 Gene

Proteins for SLC9A7 Gene

  • Protein details for SLC9A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/hydrogen exchanger 7
    Protein Accession:
    Secondary Accessions:
    • O75827
    • Q5JXP9

    Protein attributes for SLC9A7 Gene

    725 amino acids
    Molecular mass:
    80131 Da
    Quaternary structure:
    • Interacts with SCAMP1, SCAMP2 and SCAMP5; may participate in its shuttling from trans-Golgi network to recycling endosomes.
    • Is not inhibited by amiloride but by benzamil and quinine

neXtProt entry for SLC9A7 Gene

Proteomics data for SLC9A7 Gene at MOPED

Post-translational modifications for SLC9A7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC9A7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC9A7 Gene

Domains for SLC9A7 Gene

Gene Families for SLC9A7 Gene

Suggested Antigen Peptide Sequences for SLC9A7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96T83
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
genes like me logo Genes that share domains with SLC9A7: view

Function for SLC9A7 Gene

Molecular function for SLC9A7 Gene

UniProtKB/Swiss-Prot Function: Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis.

Gene Ontology (GO) - Molecular Function for SLC9A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15840657
GO:0015299 solute:proton antiporter activity --
GO:0015385 sodium:proton antiporter activity IDA 11279194
GO:0015386 potassium:proton antiporter activity IDA 11279194
GO:0042803 protein homodimerization activity TAS 11279194
genes like me logo Genes that share ontologies with SLC9A7: view

Phenotypes for SLC9A7 Gene

GenomeRNAi human phenotypes for SLC9A7:
genes like me logo Genes that share phenotypes with SLC9A7: view

Animal Model Products

CRISPR Products

miRNA for SLC9A7 Gene

miRTarBase miRNAs that target SLC9A7

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC9A7 Gene

Localization for SLC9A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC9A7 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC9A7 Gene COMPARTMENTS Subcellular localization image for SLC9A7 gene
Compartment Confidence
endosome 5
golgi apparatus 4
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC9A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005802 trans-Golgi network IDA 11279194
GO:0016021 integral component of membrane IDA 11279194
GO:0055038 recycling endosome membrane IDA 15840657
genes like me logo Genes that share ontologies with SLC9A7: view

Pathways for SLC9A7 Gene

genes like me logo Genes that share pathways with SLC9A7: view

Gene Ontology (GO) - Biological Process for SLC9A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006812 cation transport --
GO:0006814 sodium ion transport --
GO:0006885 regulation of pH IDA 11279194
GO:0035725 sodium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC9A7: view

Transcripts for SLC9A7 Gene

mRNA/cDNA for SLC9A7 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC9A7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC9A7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC9A7 Gene

No ASD Table

Relevant External Links for SLC9A7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC9A7 Gene

mRNA expression in normal human tissues for SLC9A7 Gene

mRNA differential expression in normal tissues according to GTEx for SLC9A7 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC9A7 Gene

mRNA Expression by UniProt/SwissProt for SLC9A7 Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with SLC9A7: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC9A7 Gene

Orthologs for SLC9A7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC9A7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC9A7 35
  • 97.79 (n)
  • 97.1 (a)
SLC9A7 36
  • 99 (a)
(Bos Taurus)
Mammalia SLC9A7 35
  • 91.27 (n)
  • 95.71 (a)
SLC9A7 36
  • 92 (a)
(Canis familiaris)
Mammalia SLC9A7 35
  • 90.86 (n)
  • 96.14 (a)
SLC9A7 36
  • 96 (a)
(Mus musculus)
Mammalia Slc9a7 35
  • 89.12 (n)
  • 94.77 (a)
Slc9a7 16
Slc9a7 36
  • 95 (a)
(Monodelphis domestica)
Mammalia SLC9A7 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia SLC9A7 36
  • 86 (a)
(Gallus gallus)
Aves SLC9A7 35
  • 78.23 (n)
  • 88.01 (a)
SLC9A7 36
  • 81 (a)
(Anolis carolinensis)
Reptilia SLC9A7 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc9a7 35
  • 76.23 (n)
  • 86.2 (a)
(Danio rerio)
Actinopterygii slc9a7 35
  • 73.29 (n)
  • 81.61 (a)
slc9a7 36
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nhe3 36
  • 46 (a)
Nhe3 37
  • 49 (a)
(Caenorhabditis elegans)
Secernentea nhx-5 36
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NHX1 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
Species with no ortholog for SLC9A7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC9A7 Gene

Gene Tree for SLC9A7 (if available)
Gene Tree for SLC9A7 (if available)

Paralogs for SLC9A7 Gene

Paralogs for SLC9A7 Gene

Selected SIMAP similar genes for SLC9A7 Gene using alignment to 1 proteins: Pseudogenes for SLC9A7 Gene

genes like me logo Genes that share paralogs with SLC9A7: view

Variants for SLC9A7 Gene

Sequence variations from dbSNP and Humsavar for SLC9A7 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs6640 -- 46,599,693(-) CTTGG(A/C)GTTAT utr-variant-3-prime
rs732316 -- 46,599,188(+) GCAAC(G/T)CCTCA downstream-variant-500B
rs876068 -- 46,628,702(+) AGAAC(C/T)GCCCT intron-variant
rs909662 -- 46,641,943(+) GCAAC(A/G)TAAGT intron-variant
rs1056846 -- 46,758,886(+) TCCTC(C/G)GCCGC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for SLC9A7 Gene

Variant ID Type Subtype PubMed ID
nsv6884 CNV Insertion 18451855
nsv6885 CNV Loss 18451855

Relevant External Links for SLC9A7 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC9A7 Gene

Disorders for SLC9A7 Gene

No disorders were found for SLC9A7 Gene.

No data available for UniProtKB/Swiss-Prot for SLC9A7 Gene

Publications for SLC9A7 Gene

  1. Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network. (PMID: 11279194) Numata M. … Orlowski J. (J. Biol. Chem. 2001) 2 3 4 23
  2. Identification and biochemical characterization of the SLC9A7 interactome. (PMID: 18654930) Kagami T. … Numata M. (Mol. Membr. Biol. 2008) 3 23
  3. A membrane-proximal region in the C-terminal tail of NHE7 is required for its distribution in the trans-Golgi network, distinct from NHE6 localization at endosomes. (PMID: 20364249) Fukura N. … Kanazawa H. (J. Membr. Biol. 2010) 3 23
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  5. Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7. (PMID: 15840657) Lin P.J. … Numata M. (J. Cell Sci. 2005) 3 4

Products for SLC9A7 Gene

  • antibodies-online peptides for SLC9A7
  • antibodies-online antibodies for SLC9A7
  • antibodies-online kits for SLC9A7

Sources for SLC9A7 Gene

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