Aliases for SLC9A6 Gene
External Ids for SLC9A6 Gene
This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic mental retardation, Christianson type. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
GeneCards Summary for SLC9A6 Gene
SLC9A6 (Solute Carrier Family 9, Subfamily A (NHE6, Cation Proton Antiporter 6), Member 6) is a Protein Coding gene. Diseases associated with SLC9A6 include christianson syndrome and slc9a6-related syndromic mental retardation. Among its related pathways are CREB Pathway and TCR Signaling (Qiagen). GO annotations related to this gene include sodium:proton antiporter activity. An important paralog of this gene is SLC9A4.
UniProtKB/Swiss-Prot for SLC9A6 Gene
Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis