SLC9A6 Gene
protein-coding GIFtS: 63
GCID: GC0XP135068
|
|
solute carrier family 9, subfamily A (NHE6, cation proton...(Previous names: solute carrier family 9 (sodium/hydrogen exchanger), isoform...)
| |
Aliases
for SLC9A6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 9, Subfamily A (NHE6, Cation Proton Antiporter 6),Member 61 2 | | Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 61 | | NHE61 2 3 5 | | MRSA2 | | Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 61 2 | | Sodium/Hydrogen Exchanger 62 | | KIAA02671 3 | | NHE-63 | | Na(+)/H(+) Exchanger 62 3 | | Solute Carrier Family 9 Member 63 |
Export aliases for SLC9A6 gene to outside databasesPrevious GC identifers: GC0XM129708 GC0XP131913 GC0XP133012 GC0XP133773 GC0XP134793 GC0XP134895 GC0XP124341 |
Summaries
for SLC9A6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC9A6:
This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded proteinlocalizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in thisgene are associated with X-linked syndromic mental retardation, Christianson type. Alternate splicing results inmultiple transcript variants.(provided by RefSeq, Apr 2010)
UniProtKB/Swiss-Prot: SL9A6_HUMAN, Q92581Function: Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes.Contributes to calcium homeostasis
Gene Wiki entry for SLC9A6
|
Genomic Views
for SLC9A6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC9A6 gene promoter:
POU6F1 (c2) LCR-F1 HNF-3beta Gfi-1 c-Ets-1 MZF-1 AREB6 MEF-2A STAT3 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC9A6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC9A6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq26.3 Ensembl cytogenetic band: Xq26.3 HGNC cytogenetic band: Xq26.3SLC9A6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP135068: view genomic region
(about GC identifiers)
Start:
|
135,067,583 bp from pter |
End:
|
135,129,428 bp from pter |
Size:
|
61,846 bases |
Orientation:
|
plus strand |
|
Proteins
for SLC9A6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SL9A6_HUMAN, Q92581 (See
protein sequence)Recommended Name: Sodium/hydrogen exchanger 6 Size: 669 amino acids; 74162 Da
Subcellular location: Endosome membrane; Multi-pass membrane protein. Note=Is present in the recycling compartmentsincluding early and recycling endosomes, and only appears transiently on the plasma membrane
Caution: Was originally (PubMed:9507001) identified as a mitochondrial inner membrane protein, but was later shown tobe localized in early and recycling endosomes and not mitochondria (PubMed:11940519)
Secondary accessions: A6NIQ9 A8K160 B4DU30 B7ZAE0 Q3ZCW7 Q5JPP8 Q5JPP9 Q86VS0Alternative splicing: 3 isoforms: Q92581-1 Q92581-2 Q92581-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SLC9A6: NX_Q92581
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92581
SLC9A6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001036002.1 NP_001171122.1 NP_006350.1
ENSEMBL proteins: ENSP00000359735 ENSP00000359732 ENSP00000359729 Reactome Protein details: Q92581
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
SLC9A6 for ontologies About GeneDecksing
SLC9A6 Antibody Products:
Assay Products for SLC9A6: |
Protein
Domains /
Families
for SLC9A6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC9A6 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q92581ProtoNet protein and cluster: Q92581 3 Blocks protein families: IPB002090 Na+/H+ exchanger isoform 6 (NHE6) signature IPB004709 Na+/H+ exchanger signature IPB006153 Sodium/hydrogen exchanger
UniProtKB/Swiss-Prot: SL9A6_HUMAN, Q92581Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family |
Function
for SLC9A6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SL9A6_HUMAN, Q92581Function: Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes.Contributes to calcium homeostasis Genatlas biochemistry entry for SLC9A6:solute carrier protein family 9 (sodium/hydrogen exchange),member 6,ubiquitously expressed but most abundant inbrain,skeletal muscle,heart,located in the mitochondrial inner membrane
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A6 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): SLC9A6 (NM_001042537) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC9A6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9A6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A6 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015385 | sodium:hydrogen antiporter activity |
IEA | -- |
SLC9A6 for ontologies About GeneDecksing
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Slc9a6):
SLC9A6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SLC9A6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | SLC-mediated transmembrane transport | | | 2 | Cardiac muscle contraction | | | 3 | Sodium/Proton exchangers | | | 4 | Amino acid and oligopeptide SLC transporters | | | 5 | CREB Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SLC9A6
4 
Reactome Pathways for SLC9A6
1  PharmGKB Pathway for SLC9A6
1 
Kegg Pathway (Kegg details for SLC9A6):
SLC9A6 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC9A6
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/26 Interacting proteins for SLC9A6 (Q925813 ENSP000003597294) via UniProtKB, MINT, STRING, and/or I2D (see all 26)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
SLC9A6 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC9A6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC9A6
1 HMDB Compound for SLC9A6 About this table
Search CenterWatch for drugs/clinical trials and news about SLC9A6 / SL9A6
|
Transcripts
for SLC9A6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC9A6 gene (3 alternative transcripts): NM_001042537.1 NM_001177651.1 NM_006359.2 Unigene Cluster for SLC9A6: Solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 Hs.62185 [show with all ESTs]Unigene Representative Sequence: NM_0010425373 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370701 ENST00000370698(uc004ezj.3) ENST00000370695(uc011mvx.2 uc004ezk.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A6 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): SLC9A6 (NM_001042537) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC9A6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9A6 |
Additional cDNA sequence: AB074255.1 AF030409.1 AK289775.1 AK296444.1 AK297218.1 AK300475.1 AK314562.1 AK316255.1 BC035029.1 BC047375.1 BC049169.1 D87743.1 6 DOTS entries: DT.97781564 DT.445500 DT.101967894 DT.97773849 DT.121289813 DT.97839629 24/115 AceView cDNA sequences (see all 115): AL044744 AA775547 BF903001 NM_006359 W72963 AA693901 BM670103 AA599702 BC049169 D87743 BF732582 BU621460 AF030409 CD679472 BQ009024 BQ718774 AW160475 CK818983 AI566731 AL710278 AB074255 BM126099 BQ896934 AW162354
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SLC9A6 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SLC9A6
|
Expression
for SLC9A6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC9A6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACAAGTAGA
About this image
See SLC9A6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC9A6
SOURCE GeneReport for Unigene cluster: Hs.62185
UniProtKB/Swiss-Prot: SL9A6_HUMAN, Q92581Tissue specificity: Ubiquitous; but is most abundant in mitochondrion-rich tissues such as brain, skeletal muscle andheart
SABiosciences Custom PCR Arrays for SLC9A6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC9A6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC9A6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC9A6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC9A6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A6 |
Orthologs
for SLC9A6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for SLC9A6 gene from 9/30 species (see all 30) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SLC9A61 |
solute carrier family 9 (sodium/hydrogen exchanger), more |
79.76(n)
93.09(a) |
|
422241 XM_420229.3 XP_420229.2 |
lizard
(Anolis carolinensis) |
Reptilia |
SLC9A66 |
-- |
79(a) |
1 ↔ 1 |
GL343761.1(4889-44014) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.310472 |
Xenopus laevis transcribed sequence with moderate similarity more |
81.39(n) |
|
CA987997.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
slc9a6a1 |
solute carrier family 9 (sodium/hydrogen exchanger), more |
71.39(n)
79.17(a) |
|
792983 NM_001098256.2 NP_001091726.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Nhe33 |
sodium:hydrogen antiporter |
48(a) |
|
26F6 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
nhx-56 |
Na/H eXchanger family member (nhx-5) |
40(a) |
1 → many |
X(10576898-10580992) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATNHX66NHX56 |
sodium hydrogen exchanger 5 |
30(a)30(a) |
many ↔ manymany ↔ many |
1(29952873-29957189) 1(20293151-20297133) |
rice
(Oryza sativa) |
Liliopsida |
---- |
transporter, monovalent cation:proton antiporter-2...transporter, monovalent cation:proton antiporter-2... |
27(a)24(a) |
many ↔ manymany ↔ many |
9(18542825-18548133) 9(6372268-6382644) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
yjcE6 |
predicted cation/proton antiporter |
13(a) |
1 → many |
Chromosome(4278003-4279652) |
ENSEMBL Gene Tree for SLC9A6 (if available)
TreeFam Gene Tree for SLC9A6 (if available) |
Paralogs
for SLC9A6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC9A6 gene
- SLC9A82 SLC9A32 SLC9A12 SLC9A92 SLC9A52 SLC9A22 SLC9A42 SLC9A72
3 SIMAP similar genes for SLC9A6 using alignment to 1 protein entry: SL9A6_HUMAN:SLC9A7 SLC9A9 SLC9A8
SLC9A6 for paralogs About GeneDecksing
|
Genomic Variants
for SLC9A6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC9A6 (135067583 - 135129428 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SLC9A6
1 CNV: 4174
Human Gene Mutation Database (HGMD): SLC9A6
Locus Specific Mutation Databases (LSDB): SLC9A6
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC9A6 |
|
Disorders
/ Diseases
for SLC9A6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC9A6 for disorders About GeneDecksing
OMIM gene information: 300231
OMIM disorders: 300243
UniProtKB/Swiss-Prot: SL9A6_HUMAN, Q92581
Defects in SLC9A6 are the cause of mental retardation syndromic X-linked Christianson type (MRXSCH)[MIM:300243]; also known as MRXS-Christianson or X-linked Angelman-like syndrome. The phenotype is characterized byprofound mental retardation, epilepsy, ataxia, and microcephaly, and showed phenotypic overlap with Angelman syndrome
17  diseases for SLC9A6: About MalaCardsmental retardation, x-linked mental retardation, x-linked syndromic mental retardation epilepsy mental retardation syndrome
intellectual disability ophthalmoplegia angelman syndrome leptospirosis
cystic fibrosis neurologic diseases microcephaly fibrosis
ataxia pneumonia tuberculosis neuronitis
mycobacterium tuberculosis
1 disease from the University of Copenhagen DISEASES database for SLC9A6:Angelman syndrome Human Genome Epidemiology (HuGE) Navigator: SLC9A6 (2 documents)
Export disorders for SLC9A6 gene to outside databases
|
Publications
for SLC9A6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC9A6 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with SLC9A6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a mitochondrial Na+/H+ exchanger. (PubMed id 9507001)1, 2, 3 Numata M.... Orlowski J. (1998)
- SLC9A6 mutations cause X-linked mental retardation, microcephaly, epilepsy, and ataxia, a phenotype mimicking Angelman syndrome. (PubMed id 18342287)1, 2, 9 Gilfillan G.D....Stromme P. (2008)
- Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria. (PubMed id 11940519)1, 2, 9 Brett C.L.... Rao R. (2002)
- Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
- Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
- High capacity Na+/H+ exchange activity in mineralizin g osteoblasts. (PubMed id 21413028)1 Liu L....Blair H.C. (2011)
- Na+/H+ exchanger isoform 6 (NHE6/SLC9A6) is involved in clathrin-dependent endocytosis of transferrin. (PubMed id 21881004)1 Xinhan L....Kanazawa H. (2011)
- A loss-of-function mutation in the SLC9A6 gene causes X-linked mental retardation resembling Angelman syndrome. (PubMed id 21812100)1 Takahashi Y....Saitoh S. (2011)
- Organellar Na+/H+ exchangers: novel players in organe lle pH regulation and their emerging functions. (PubMed id 21171650)1 Ohgaki R....Kanazawa H. (2011)
- A mutation affecting the sodium/proton exchanger, SLC 9A6, causes mental retardation with tau deposition. (PubMed id 20395263)1 Garbern J.Y....Sima A.A. (2010)
|
External Searches for SLC9A6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC9A6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC9A6 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SLC9A6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC9A6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC9A6 gene:
Search GeneIP for patents involving SLC9A6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SLC9A6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC9A6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC9A6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC9A6 | | | OriGene Protein Over-expression Lysate for SLC9A6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC9A6 | | OriGene 3'-UTR Clone for SLC9A6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SLC9A6 | | OriGene Custom Protein Services for SLC9A6 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC9A6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC9A6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC9A6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC9A6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC9A6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC9A6 |
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| | | | Search Tocris compounds for SLC9A6 |
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 | | | SLC9A6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A6 |
|  |  |  | | | | Search ThermoFisher Antibodies for SLC9A6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9A6 |
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