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SLC9A5 Gene

protein-coding   GIFtS: 58
GCID: GC16P067282

Solute Carrier Family 9, Subfamily A (NHE5, Cation Proton...

(Previous names: solute carrier family 9 (sodium/hydrogen exchanger), isoform...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 9, Subfamily A (NHE5, Cation Proton Antiporter
5), Member 51 2
     Na(+)/H(+) Exchanger 52 3
NHE52 3 5     Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 51
Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 51 2     Sodium/Hydrogen Exchanger 52
Solute Carrier Family 9 Member 52 3     Solute Carrier Family 9 (Sodium/Hydrogen Exchanger)2
NHE-52 3     

External Ids:    HGNC: 110781   Entrez Gene: 65532   Ensembl: ENSG000001357407   OMIM: 6004775   UniProtKB: Q149403   

Export aliases for SLC9A5 gene to outside databases

Previous GC identifers: GC16M076428 GC16P067660 GC16P067018 GC16P067059 GC16P065840 GC16P053155


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC9A5 Gene:
SLC9A5 (solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5) is a protein-coding gene. Diseases associated with SLC9A5 include familial paroxysmal kinesigenic dyskinesia, and north american indian childhood cirrhosis. GO annotations related to this gene include sodium:hydrogen antiporter activity. An important paralog of this gene is SLC9A3.

UniProtKB/Swiss-Prot: SL9A5_HUMAN, Q14940
Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse
environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays
an important role in signal transduction (By similarity)

Gene Wiki entry for SLC9A5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC9A5 gene promoter:
         ER-alpha   E2F-4   E2F-3a   E2F-5   E2F-2   NF-kappaB   E2F   E2F-1   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC9A5 promoter sequence
   Search Chromatin IP Primers for SLC9A5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC9A5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

SLC9A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC9A5 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P067282:  view genomic region     (about GC identifiers)

Start:
67,271,586 bp from pter      End:
67,306,094 bp from pter
Size:
34,509 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SL9A5_HUMAN, Q14940 (See protein sequence)
Recommended Name: Sodium/hydrogen exchanger 5  
Size: 896 amino acids; 99011 Da
Subunit: Interacts with CHP1 and CHP2 (By similarity). Interacts with ARRB2
Caution: The number, localization and denomination of hydrophobic domains in the Na(+)/H(+) exchangers vary among
authors
Secondary accessions: A5PKY7 Q9Y626

Explore the universe of human proteins at neXtProt for SLC9A5: NX_Q14940

Explore proteomics data for SLC9A5 at MOPED

Post-translational modifications: 

  • Phosphorylated (Possible)1
  • Glycosylation2 at Asn199, Asn319
  • Modification sites at PhosphoSitePlus

  • See SLC9A5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004585.1  
    ENSEMBL proteins: 
     ENSP00000462446   ENSP00000455058   ENSP00000299798   ENSP00000464393   ENSP00000462404  
    Reactome Protein details: Q14940

    SLC9A5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Sodium/hydrogen exchanger 5
    SLC9 family of sodium/hydrogen exchangers

    4 InterPro protein domains:
     IPR018410 Na/H_exchanger_3/5
     IPR006153 Cation/H_exchanger
     IPR018422 Cation/H_exchanger_CPA1
     IPR004709 NaH_exchanger

    Graphical View of Domain Structure for InterPro Entry Q14940

    ProtoNet protein and cluster: Q14940

    2 Blocks protein domains:
    IPB004709 Na+/H+ exchanger signature
    IPB006153 Sodium/hydrogen exchanger


    UniProtKB/Swiss-Prot: SL9A5_HUMAN, Q14940
    Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family


    SLC9A5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SL9A5_HUMAN, Q14940
    Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse
    environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays
    an important role in signal transduction (By similarity)

         Genatlas biochemistry entry for SLC9A5:
    solute carrier protein family 9 (sodium/hydrogen exchange),member 5,involved in intracellular pH regulation and
    cell volume,isoform 5,expressed in multiple regions of the brains including hippocampus

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015299solute:hydrogen antiporter activity ----
    GO:0015385sodium:hydrogen antiporter activity IEA--
         
    SLC9A5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC9A5:
     Increased Salmonella enterica  

    Animal Models:
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    hsa-mir-192-5p (MIRT026697)

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    6 qRT-PCR Assays for microRNAs that regulate SLC9A5:
    hsa-miR-22 hsa-miR-4251 hsa-miR-2110 hsa-miR-4268 hsa-miR-1322 hsa-miR-1224-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC9A5 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SL9A5_HUMAN, Q14940: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol2
    endosome2
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    SLC9A5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC9A5 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Sodium/Proton exchangers0.00
    2Sweet Taste Signaling
    Sperm Motility0.37
    3ADP signalling through P2Y purinoceptor 12
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SLC9A5
        Sperm Motility

    1 Reactome Pathway for SLC9A5
        Sodium/Proton exchangers

    1 PharmGKB Pathway for SLC9A5
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics


    SLC9A5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC9A5
    Interactions:

        GeneGlobe Interaction Network for SLC9A5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for SLC9A5 (Q149403 ENSP000002997984) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARRB2P321213, ENSP000002692604I2D: score=2 STRING: ENSP00000269260
    CHP1Q996533, ENSP000003356324I2D: score=2 STRING: ENSP00000335632
    ARRB1P494073, ENSP000003771414I2D: score=1 STRING: ENSP00000377141
    CHP2O437453, ENSP000003001134I2D: score=1 STRING: ENSP00000300113
    BRAPENSP000003308134STRING: ENSP00000330813
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS9933641
    GO:0006811ion transport TAS--
    GO:0006812cation transport ----
    GO:0006814sodium ion transport ----
    GO:0006885regulation of pH IEA--

    SLC9A5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC9A5 (SL9A5)

    1 HMDB Compound for SLC9A5    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    3 Novoseek inferred chemical compound relationships for SLC9A5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amiloride 55.4 3 10692428 (2), 9933642 (1)
    sodium 22.5 2 12203045 (1), 11113072 (1)
    hydrogen 16.3 2 12203045 (1), 11113072 (1)



    SLC9A5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC9A5 gene: 
    NM_004594.2  

    Unigene Cluster for SLC9A5:

    Solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
    Hs.439650  [show with all ESTs]
    Unigene Representative Sequence: BC150207
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000564704 ENST00000566345 ENST00000564812 ENST00000299798(uc002esm.3 uc010vji.2)
    ENST00000563723(uc010cee.3) ENST00000561472 ENST00000566638 ENST00000567247
    ENST00000566626
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    6 qRT-PCR Assays for microRNAs that regulate SLC9A5:
    hsa-miR-22 hsa-miR-4251 hsa-miR-2110 hsa-miR-4268 hsa-miR-1322 hsa-miR-1224-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC9A5 3' UTR sequence
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    Additional mRNA sequence: 

    AF111173.1 AL137689.1 BC142671.1 BC144131.1 BC150207.1 

    6 DOTS entries:

    DT.403297  DT.91668787  DT.437336  DT.40129161  DT.95362238  DT.120726262 

    Selected AceView cDNA sequences (see all 46):

    AA868139 AW514065 AW005101 CB105338 BX280935 BQ773107 BG117579 AK021876 
    AI220297 BI758279 BQ070441 AK091748 NM_004594 BE905509 AU119677 AL137689 
    BQ189443 BQ225454 BM971593 AI042531 BG029754 AF111173 AI909208 AL541352 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC9A5    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                          -     -     -     -     -     -     -     -     -     -                           
    SP2:                                -     -     -     -     -     -     -     -     -                           
    SP3:                                                                                                            
    SP4:                          -     -     -     -     -     -     -     -                                       
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for SLC9A5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC9A5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCACCACCTG
    SLC9A5 Expression
    About this image


    SLC9A5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    SLC9A5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC9A5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.439650

    UniProtKB/Swiss-Prot: SL9A5_HUMAN, Q14940
    Tissue specificity: Expressed in brain, testis, spleen, and skeletal muscle

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC9A5 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc9a51 , 5 solute carrier family 9 (sodium/hydrogen exchanger), more1, 5 90.31(n)1
    95.78(a)1
      8 (53.04 cM)5
    2779731  NM_001081332.11  NP_001074801.11 
     1053482585 
    chicken
    (Gallus gallus)
    Aves SLC9A51 solute carrier family 9, subfamily A (NHE5, cation more 74.2(n)
    76.92(a)
      425403  XM_003641901.2  XP_003641949.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc9a51 solute carrier family 9, subfamily A (NHE5, cation more 66.55(n)
    71.14(a)
      100497776  XM_002931691.2  XP_002931737.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc9a51 solute carrier family 9 (sodium/hydrogen exchanger), more 64.3(n)
    64.01(a)
      565213  NM_001113472.1  NP_001106943.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nhe21 Na[+]/H[+] hydrogen exchanger 2 53.26(n)
    45.47(a)
      35376  NM_001144375.2  NP_001137847.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nhx-33 Expression: hypodermal 44(a)
    (best of 5)
      V(7543558-7546424)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NHX16
    Na+/H+ and K+/H+ exchanger, required for intracell...
    21(a)
    1 → many
    IV(1367485-1369386) YDR456W


    ENSEMBL Gene Tree for SLC9A5 (if available)
    TreeFam Gene Tree for SLC9A5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC9A5 gene
    SLC9A32  SLC9A62  SLC9A82  SLC9A12  SLC9A92  SLC9A22  SLC9A72  SLC9A42  
    5 SIMAP similar genes for SLC9A5 using alignment to 5 protein entries:     SL9A5_HUMAN (see all proteins):
    DKFZp434N222    SLC9A3    SLC9A1    SLC9A4    SLC9A2

    SLC9A5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC9A5 (see all 434)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1427723561,2
    --67283661(+) ACCCCC/GCCAAC 1 -- int10--------
    rs1177881911,2
    C,F--67283674(+) ACGTTC/GAGGTC 1 -- int11Minor allele frequency- G:0.03EA 120
    rs783237611,2
    C,F--67283721(+) TGTATC/TGGGGC 1 -- int11Minor allele frequency- T:0.17WA 118
    rs39093641,2
    H--67283840(-) GATGCA/TAGGAA 1 -- int14Minor allele frequency- T:0.00NS EA 418
    rs1863857531,2
    --67283921(+) GTTGTG/TCTGGC 1 -- int10--------
    rs1469526701,2
    C--67284018(+) TACAGC/GCTTCA 1 -- int10--------
    rs1127996651,2
    C--67284305(+) ATGACC/TATGTT 1 -- int10--------
    rs1416136171,2
    --67284364(+) GGTTTA/GGAGCC 1 -- int10--------
    rs1916062171,2
    --67284374(+) CAACGA/TTTGGG 1 -- int10--------
    rs1834674011,2
    --67284492(+) CTATGC/GAAGTA 1 -- int10--------

    HapMap Linkage Disequilibrium report for SLC9A5 (67271586 - 67306094 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLC9A5 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668436CNV Deletion23128226
    dgv2888n71CNV Loss21882294
    nsv906803CNV Loss21882294
    dgv2886n71CNV Loss21882294
    nsv524492CNV Loss19592680
    nsv827707CNV Loss20364138
    nsv457513CNV Loss19166990
    dgv2885n71CNV Loss21882294
    nsv524363CNV Loss19592680
    esv9318CNV Gain19470904

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC9A5
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC9A5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600477    OMIM disorders: --

    7 diseases for SLC9A5:    
    About MalaCards
    familial paroxysmal kinesigenic dyskinesia    north american indian childhood cirrhosis    leptospirosis    diarrhea
    pneumonia    tuberculosis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SLC9A5:
    Leptospirosis

    SLC9A5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC9A5

    Export disorders for SLC9A5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC9A5 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with SLC9A5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1. (PubMed id 7759094)1, 2, 3 Klanke C.A....Menon A.G. (Genomics 1995)
    2. Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain. (PubMed id 9933641)1, 2, 9 Baird N.R.... Shull G.E. (J. Biol. Chem. 1999)
    3. Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain. (PubMed id 9933642)1, 3, 9 Attaphitaya S....Melvin J.E. (J. Biol. Chem. 1999)
    4. beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform. (PubMed id 15699339)1, 2 Szabo E.Z.... Orlowski J. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    5. RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity. (PubMed id 16920332)1, 9 Onishi I....Numata M. (Cell. Signal. 2007)
    6. CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis. (PubMed id 21296876)1 Lukashova V....Orlowski J. (J. Biol. Chem. 2011)
    7. Regulation of dendritic spine growth through activity-dependent recruitment of the brain-enriched Naa8_/Ha8_ exchanger NHE5. (PubMed id 21551074)1 Diering G.H....Numata M. (Mol. Biol. Cell 2011)
    8. Secretory Carrier Membrane Protein 2 Regulates Cell-surface Targeting of Brain-enriched Na+/H+ Exchanger NHE5. (PubMed id 19276089)1 Diering G.H....Numata M. (J. Biol. Chem. 2009)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6553 HGNC: 11078 AceView: SLC9A5 Ensembl:ENSG00000135740 euGenes: HUgn6553
    ECgene: SLC9A5 H-InvDB: SLC9A5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC9A5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC9A5 gene:
    Search GeneIP for patents involving SLC9A5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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