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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC9A5 Gene

protein-coding   GIFtS: 59
GCID: GC16P067282

solute carrier family 9, subfamily A (NHE5, cation proton...

(Previous names: solute carrier family 9 (sodium/hydrogen exchanger), isoform...)
 Explore 7 diseases affiliated with
SLC9A5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC9A5    

Aliases
for SLC9A5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 9, Subfamily A (NHE5, Cation Proton Antiporter 5),
Member 51 2
     Na(+)/H(+) Exchanger 52 3
NHE51 2 3 5     Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 51
Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 51 2     Sodium/Hydrogen Exchanger 52
Solute Carrier Family 9 Member 52 3     Solute Carrier Family 9 (Sodium/Hydrogen Exchanger)2
NHE-52 3     

External Ids:    HGNC: 110781   Entrez Gene: 65532   Ensembl: ENSG000001357407   OMIM: 6004775   UniProtKB: Q149403   

Export aliases for SLC9A5 gene to outside databases

Previous GC identifers: GC16M076428 GC16P067660 GC16P067018 GC16P067059 GC16P065840 GC16P053155


Summaries
for SLC9A5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SL9A5_HUMAN, Q14940
Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse
environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an
important role in signal transduction (By similarity)

Gene Wiki entry for SLC9A5


Genomic Views
for SLC9A5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC9A5 gene promoter:
         ER-alpha   E2F-4   E2F-3a   E2F-5   E2F-2   NF-kappaB   E2F   E2F-1   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC9A5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC9A5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC9A5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

SLC9A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC9A5 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P067282:  view genomic region     (about GC identifiers)

Start:
 67,271,586 bp from pter      End:
 67,306,094 bp from pter
Size:
 34,509 bases      Orientation:
 plus strand

Proteins
for SLC9A5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SL9A5_HUMAN, Q14940 (See protein sequence)
Recommended Name: Sodium/hydrogen exchanger 5  
Size: 896 amino acids; 99011 Da
Subunit: Interacts with CHP1 and CHP2 (By similarity). Interacts with ARRB2
Subcellular location: Membrane; Multi-pass membrane protein
Caution: The number, localization and denomination of hydrophobic domains in the Na(+)/H(+) exchangers vary among
authors
Secondary accessions: A5PKY7 Q9Y626

Explore the universe of human proteins at neXtProt for SLC9A5: NX_Q14940

Post-translational modifications:

  • Phosphorylated (Possible)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14940

    • SLC9A5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004585.1  
    ENSEMBL proteins: 
     ENSP00000462446   ENSP00000455058   ENSP00000299798   ENSP00000464393   ENSP00000462404  
    Reactome Protein details: Q14940
    Human Recombinant Protein Products: 
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    Novus Biologicals SLC9A5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC9A5

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--


    SLC9A5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC9A5

    Protein Domains /
    Families
    for SLC9A5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC9A5 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018422 Cation/H_exchanger_CPA1
     IPR018410 Na/H_exchanger_3/5
     IPR004709 NaH_exchanger
     IPR006153 Cation/H_exchanger

    Graphical View of Domain Structure for InterPro Entry Q14940

    ProtoNet protein and cluster: Q14940

    2 Blocks protein families:
    IPB004709 Na+/H+ exchanger signature
    IPB006153 Sodium/hydrogen exchanger


    UniProtKB/Swiss-Prot: SL9A5_HUMAN, Q14940
    Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family


    Function
    for SLC9A5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SL9A5_HUMAN, Q14940
    Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse
    environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an
    important role in signal transduction (By similarity)

         Genatlas biochemistry entry for SLC9A5:
    solute carrier protein family 9 (sodium/hydrogen exchange),member 5,involved in intracellular pH regulation and cell
    volume,isoform 5,expressed in multiple regions of the brains including hippocampus

    miRNA
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    hsa-miR-22 hsa-miR-4251 hsa-miR-2110 hsa-miR-4268 hsa-miR-1322 hsa-miR-1224-5p
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015385sodium:hydrogen antiporter activity IEA--


    SLC9A5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SLC9A5:
     Increased Salmonella enterica  


    Pathways & Interactions
    for SLC9A5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50
    2Sodium/Proton exchangers
    		Sodium/Proton exchangers1.00
    3Amino acid and oligopeptide SLC transporters
    		Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    4Sweet Taste Signaling
    		Sperm Motility0.36
    5Opioid Signalling
    		Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.35

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SLC9A5
        Sperm Motility

    4        Reactome Pathways for SLC9A5
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Sodium/Proton exchangers
    Transport of inorganic cations/anions and amino acids/oligopeptides

    1 PharmGKB Pathway for SLC9A5
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics


    SLC9A5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC9A5

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for SLC9A5 (Q149403 ENSP000002997984) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARRB2P321213, ENSP000002692604I2D: score=2 STRING: ENSP00000269260
    CHP1Q996533, ENSP000003356324I2D: score=2 STRING: ENSP00000335632
    ARRB1P494073, ENSP000003771414I2D: score=1 STRING: ENSP00000377141
    CHP2O437453, ENSP000003001134I2D: score=1 STRING: ENSP00000300113
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS9933641
    GO:0006811ion transport TAS--
    GO:0006814sodium ion transport ----
    GO:0006885regulation of pH IEA--
    GO:0015992proton transport ----


    SLC9A5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC9A5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC9A5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SLC9A5

    1 HMDB Compound for SLC9A5    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--
    3 Novoseek chemical compound relationships for SLC9A5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amiloride 55.4 3 10692428 (2), 9933642 (1)
    sodium 22.5 2 12203045 (1), 11113072 (1)
    hydrogen 16.3 2 12203045 (1), 11113072 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC9A5 / SL9A5 

    Transcripts
    for SLC9A5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC9A5 gene: 
    NM_004594.2  

    Unigene Cluster for SLC9A5:

    Solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
    Hs.439650  [show with all ESTs]
    Unigene Representative Sequence: BC150207
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000564704 ENST00000566345 ENST00000564812 ENST00000299798(uc002esm.3 uc010vji.2)
    ENST00000563723(uc010cee.3) ENST00000561472 ENST00000566638 ENST00000567247
    ENST00000566626

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC9A5:
    hsa-miR-22 hsa-miR-4251 hsa-miR-2110 hsa-miR-4268 hsa-miR-1322 hsa-miR-1224-5p
    SwitchGear 3'UTR luciferase reporter plasmid: SLC9A5 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: SLC9A5
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF111173.1 AL137689.1 BC142671.1 BC144131.1 BC150207.1 

    6 DOTS entries:

    DT.403297  DT.91668787  DT.437336  DT.40129161  DT.95362238  DT.120726262 

    24/46 AceView cDNA sequences (see all 46):

    AA868139 CB105338 AW005101 AW514065 BX280935 BG117579 BQ773107 AI220297 
    AK091748 AK021876 BE905509 AF111173 AI042531 BI758279 NM_004594 BQ070441 
    BM971593 BG029754 BQ225454 BQ189443 AU119677 AL137689 AI909208 AL541352 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC9A5    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                          -     -     -     -     -     -     -     -     -     -                           
    SP2:                                -     -     -     -     -     -     -     -     -                           
    SP3:                                                                                                            
    SP4:                          -     -     -     -     -     -     -     -                                       
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for SLC9A5

    Expression
    for SLC9A5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC9A5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCACCACCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC9A5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC9A5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC9A5

    SOURCE GeneReport for Unigene cluster: Hs.439650

    UniProtKB/Swiss-Prot: SL9A5_HUMAN, Q14940
    Tissue specificity: Expressed in brain, testis, spleen, and skeletal muscle

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    In Situ
    Assay Products:     
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    Orthologs
    for SLC9A5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for SLC9A5 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC4254031 sodium/hydrogen exchanger 5-like 73.88(n)
    76.4(a)    		   425403  XM_003641901.1  XP_003641949.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii slc9a51 solute carrier family 9 (sodium/hydrogen exchanger), more 63.87(n)
    63.2(a)    		   565213  NM_001113472.1  NP_001106943.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Nhe26
    		 Na[+]/H[+] hydrogen exchanger 2
    		 23(a)
    		 1 → many
    		 2L(21104599-21134255)
    worm
    (Caenorhabditis elegans)    		 Secernentea nhx-33 Expression: hypodermal 44(a)
    (best of 5)    		   V(7543558-7546424)   --
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria yjcE6
    		 predicted cation/proton antiporter
    		 14(a)
    		 1 → many
    		 Chromosome(4278003-4279652)


    ENSEMBL Gene Tree for SLC9A5 (if available)
    TreeFam Gene Tree for SLC9A5 (if available) 

    Paralogs
    for SLC9A5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC9A5 gene
    SLC9A62  SLC9A32  SLC9A42  SLC9A82  SLC9A12  SLC9A92  SLC9A22  SLC9A72  
    5 SIMAP similar genes for SLC9A5 using alignment to 5 protein entries:     SL9A5_HUMAN (see all proteins):
    DKFZp434N222    SLC9A3    SLC9A1    SLC9A4    SLC9A2

    SLC9A5 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC9A5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/309 NCBI SNPs in SLC9A5 are shown (see all 309)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs38527021,2
    		C,F,A,H,--53154083(+) CGGAGA/GAGAAC 1 -- int112Minor allele frequency- G:0.16MN NS EA NA WA CSA 909
    rs38527031,2
    		C,F,A,H,--53154113(+) CGCGGA/GGCACC 1 -- int116Minor allele frequency- G:0.22MN NS EA NA WA CSA 1575
    rs80503071,2
    		C,F,--53154767(+) GGCAGA/TTGGGG 1 -- us2k11Minor allele frequency- T:0.18WA 118
    rs1123291821,2
    		C,--53154820(+) TGAGGG/AACAAG 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs71920831,2
    		C,--53154866(+) CTGTGG/ATTTCC 1 -- us2k1 tfbs35Minor allele frequency- A:0.31WA CSA NA 243
    rs129224831,2
    		C,F,H,--53155308(+) TGGTTT/CGGGAG 1 -- us2k114Minor allele frequency- C:0.04NS EA NA 1538
    rs1127891581,2
    		C,--53155326(+) ACAGCC/TTCCCT 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs590553171,2
    		--53155445(+) AGGTCT/CGGGTG 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs129260031,2
    		C--53155807(+) GGAGAG/TAGTCC 1 -- us2k1 trp30--------
    rs2020016501,2
    		C--53156208(+) GGCCGA/CCCGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC9A5 (67271586 - 67306094 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SLC9A5
         1 CNV: 58770
         1 Indel: 60213

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    Disorders / Diseases
    for SLC9A5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC9A5 for disorders           About GeneDecksing

    OMIM gene information: 600477    OMIM disorders: --

    7 diseases for SLC9A5:    About MalaCards
    north american indian childhood cirrhosis    leptospirosis    diarrhea    pneumonia
    tuberculosis    neuronitis    mycobacterium tuberculosis

    1 disease from the University of Copenhagen DISEASES database for SLC9A5:
    Leptospirosis

    Export disorders for SLC9A5 gene to outside databases

    Publications
    for SLC9A5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC9A5 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with SLC9A5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1. (PubMed id 7759094)1, 2, 3 Klanke C.A....Menon A.G. (1995)
    2. Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain. (PubMed id 9933641)1, 2, 9 Baird N.R.... Shull G.E. (1999)
    3. Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain. (PubMed id 9933642)1, 3, 9 Attaphitaya S....Melvin J.E. (1999)
    4. beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform. (PubMed id 15699339)1, 2 Szabo E.Z....Orlowski J. (2005)
    5. RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity. (PubMed id 16920332)1, 9 Onishi I....Numata M. (2007)
    6. CK2 phosphorylation of an acidic Ser/Thr di-isoleucin e motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arr estin2 and endocytosis. (PubMed id 21296876)1 Lukashova V....Orlowski J. (2011)
    7. Regulation of dendritic spine growth through activity -dependent recruitment of the brain-enriched Naa8_/Ha8_ exchanger NHE5. (PubMed id 21551074)1 Diering G.H....Numata M. (2011)
    8. Secretory Carrier Membrane Protein 2 Regulates Cell-surface Targeting of Brain-enriched Na+/H+ Exchanger NHE5. (PubMed id 19276089)1 Diering G.H....Numata M. (2009)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for SLC9A5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing SLC9A5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6553 HGNC: 11078 AceView: SLC9A5 Ensembl:ENSG00000135740 euGenes: HUgn6553
    ECgene: SLC9A5 H-InvDB: SLC9A5

    Other Databases showing SLC9A5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC9A5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC9A5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC9A5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC9A5 gene:
    Search GeneIP for patents involving SLC9A5

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