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Aliases for SLC9A4 Gene

Aliases for SLC9A4 Gene

  • Solute Carrier Family 9 Member A4 2 3
  • Solute Carrier Family 9, Subfamily A (NHE4, Cation Proton Antiporter 4), Member 4 2 3 5
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 4 2 3
  • Solute Carrier Family 9 Member 4 3 4
  • Na(+)/H(+) Exchanger 4 3 4
  • NHE-4 3 4
  • NHE4 3 4
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 4 2
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger) 3

External Ids for SLC9A4 Gene

Previous GeneCards Identifiers for SLC9A4 Gene

  • GC02U990082
  • GC02P102745
  • GC02P103089
  • GC02P096854

Summaries for SLC9A4 Gene

GeneCards Summary for SLC9A4 Gene

SLC9A4 (Solute Carrier Family 9 Member A4) is a Protein Coding gene. Diseases associated with SLC9A4 include koolen-de vries syndrome and active peptic ulcer disease. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Salivary secretion. GO annotations related to this gene include solute:proton antiporter activity and sodium:proton antiporter activity. An important paralog of this gene is SLC9A9.

UniProtKB/Swiss-Prot for SLC9A4 Gene

  • Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4-diisothiocyanostilbene-2,2-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC9A4 Gene

Genomics for SLC9A4 Gene

Regulatory Elements for SLC9A4 Gene

Genomic Location for SLC9A4 Gene

Chromosome:
2
Start:
102,473,282 bp from pter
End:
102,533,974 bp from pter
Size:
60,693 bases
Orientation:
Plus strand

Genomic View for SLC9A4 Gene

Genes around SLC9A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC9A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC9A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC9A4 Gene

Proteins for SLC9A4 Gene

  • Protein details for SLC9A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6AI14-SL9A4_HUMAN
    Recommended name:
    Sodium/hydrogen exchanger 4
    Protein Accession:
    Q6AI14
    Secondary Accessions:
    • Q69YK0

    Protein attributes for SLC9A4 Gene

    Size:
    798 amino acids
    Molecular mass:
    89814 Da
    Quaternary structure:
    • Interacts with CHP1 and CHP2.

neXtProt entry for SLC9A4 Gene

Proteomics data for SLC9A4 Gene at MOPED

Post-translational modifications for SLC9A4 Gene

Other Protein References for SLC9A4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC9A4 Gene

Domains & Families for SLC9A4 Gene

Gene Families for SLC9A4 Gene

Suggested Antigen Peptide Sequences for SLC9A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6AI14

UniProtKB/Swiss-Prot:

SL9A4_HUMAN :
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Family:
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
genes like me logo Genes that share domains with SLC9A4: view

Function for SLC9A4 Gene

Molecular function for SLC9A4 Gene

GENATLAS Biochemistry:
solute carrier protein family 9 (sodium/hydrogen exchange),member 4,involved in intracellular pH regulation and cell volume,isoform 4,expressed in stomach,kidney,brain,uterus,skeletalmuscle
UniProtKB/Swiss-Prot Function:
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4-diisothiocyanostilbene-2,2-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for SLC9A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015299 solute:proton antiporter activity IEA --
genes like me logo Genes that share ontologies with SLC9A4: view
genes like me logo Genes that share phenotypes with SLC9A4: view

Animal Models for SLC9A4 Gene

MGI Knock Outs for SLC9A4:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC9A4 Gene

Localization for SLC9A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC9A4 Gene

Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic granule membrane; Multi-pass membrane protein. Note=Found in zymogen granule membranes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC9A4 Gene COMPARTMENTS Subcellular localization image for SLC9A4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC9A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with SLC9A4: view

Pathways & Interactions for SLC9A4 Gene

genes like me logo Genes that share pathways with SLC9A4: view

Gene Ontology (GO) - Biological Process for SLC9A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002064 epithelial cell development IEA --
GO:0006812 cation transport IEA --
GO:0035725 sodium ion transmembrane transport IEA,TAS --
GO:0055085 transmembrane transport IEA --
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC9A4: view

No data available for SIGNOR curated interactions for SLC9A4 Gene

Drugs & Compounds for SLC9A4 Gene

(1) Additional Compounds for SLC9A4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC9A4: view

Transcripts for SLC9A4 Gene

mRNA/cDNA for SLC9A4 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC9A4 Gene

Solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC9A4 Gene

No ASD Table

Relevant External Links for SLC9A4 Gene

GeneLoc Exon Structure for
SLC9A4
ECgene alternative splicing isoforms for
SLC9A4

Expression for SLC9A4 Gene

mRNA expression in normal human tissues for SLC9A4 Gene

mRNA differential expression in normal tissues according to GTEx for SLC9A4 Gene

This gene is overexpressed in Stomach (x39.8) and Kidney - Cortex (x4.9).

SOURCE GeneReport for Unigene cluster for SLC9A4 Gene Hs.447686

genes like me logo Genes that share expression patterns with SLC9A4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC9A4 Gene

Orthologs for SLC9A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC9A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC9A4 35
  • 99.37 (n)
  • 99.5 (a)
SLC9A4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC9A4 36
  • 81 (a)
OneToOne
SLC9A4 35
  • 83.25 (n)
  • 81.03 (a)
dog
(Canis familiaris)
Mammalia SLC9A4 35
  • 86.81 (n)
  • 88.32 (a)
mouse
(Mus musculus)
Mammalia Slc9a4 16
Slc9a4 35
  • 82.79 (n)
  • 83.54 (a)
Slc9a4 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC9A4 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC9A4 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc9a4 35
  • 85.01 (n)
  • 88.02 (a)
chicken
(Gallus gallus)
Aves SLC9A4 35
  • 71.84 (n)
  • 73.82 (a)
SLC9A4 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc9a4 35
  • 66.99 (n)
  • 67.25 (a)
zebrafish
(Danio rerio)
Actinopterygii slc9a2 36
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Nhe2 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nhx-1 36
  • 35 (a)
ManyToMany
nhx-2 36
  • 34 (a)
ManyToMany
nhx-3 36
  • 33 (a)
ManyToMany
nhx-6 36
  • 34 (a)
ManyToMany
nhx-9 36
  • 35 (a)
ManyToMany
Species with no ortholog for SLC9A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC9A4 Gene

ENSEMBL:
Gene Tree for SLC9A4 (if available)
TreeFam:
Gene Tree for SLC9A4 (if available)

Paralogs for SLC9A4 Gene

Paralogs for SLC9A4 Gene

(4) SIMAP similar genes for SLC9A4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC9A4: view

Variants for SLC9A4 Gene

Sequence variations from dbSNP and Humsavar for SLC9A4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs17027275 - 102,478,928(+) TCTTC(A/G)GCACC reference, missense
VAR_056210 -
rs759381 -- 102,477,864(-) GAGAG(A/T)TCAGA intron-variant
rs737231 -- 102,488,041(-) GGATT(C/T)TAATA intron-variant
rs1003431 -- 102,530,797(-) CATTA(A/G)TTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC9A4 Gene

Variant ID Type Subtype PubMed ID
nsv523406 CNV Loss 19592680
esv2667694 CNV Deletion 23128226
nsv874754 CNV Loss 21882294
nsv874755 CNV Gain 21882294

Variation tolerance for SLC9A4 Gene

Residual Variation Intolerance Score: 35.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC9A4 Gene

HapMap Linkage Disequilibrium report
SLC9A4
Human Gene Mutation Database (HGMD)
SLC9A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC9A4 Gene

Disorders for SLC9A4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC9A4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
koolen-de vries syndrome
  • koolen de vries syndrome
active peptic ulcer disease
  • gi bleeding
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC9A4

Genetic Association Database (GAD)
SLC9A4
Human Genome Epidemiology (HuGE) Navigator
SLC9A4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC9A4
genes like me logo Genes that share disorders with SLC9A4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC9A4 Gene

Publications for SLC9A4 Gene

  1. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PMID: 21738478) Okada Y. … Kamatani N. (PLoS Genet. 2011) 3 48 67
  2. NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells. (PMID: 17943310) BeltrA!n A.R. … Malnic G. (Pflugers Arch. 2008) 3 23
  3. Chromosomal assignment of four genes encoding Na/H exchanger isoforms in human and rat. (PMID: 8199403) Szpirer C. … Orlowski J. (Mamm. Genome 1994) 2 3
  4. Macropinocytosis and TAK1 mediate anti-inflammatory to pro-inflammatory macrophage differentiation by HIV-1 Nef. (PMID: 24874739) Hashimoto M. … Suzu S. (Cell Death Dis 2014) 3
  5. Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling. (PMID: 23999434) Ho J.E. … Wang T.J. (J. Clin. Invest. 2013) 3

Products for SLC9A4 Gene

Sources for SLC9A4 Gene

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