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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC9A4 Gene

protein-coding   GIFtS: 51
GCID: GC02P103089

solute carrier family 9, subfamily A (NHE4, cation proton...

(Previous names: solute carrier family 9 (sodium/hydrogen exchanger), isoform...)
 Explore 5 diseases affiliated with
SLC9A4 via our new
 Human Malady Compendium 
Biological research products
for SLC9A4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Solute Carrier Family 9, Subfamily A (NHE4, Cation Proton Antiporter 4),
Member 41 2
     Na(+)/H(+) Exchanger 42 3
NHE41 2 3 5     Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 41
Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 41 2     Sodium/Hydrogen Exchanger 42
Solute Carrier Family 9 Member 42 3     Solute Carrier Family 9 (Sodium/Hydrogen Exchanger)2
NHE-42 3     

External Ids:    HGNC: 110771   Entrez Gene: 3890152   Ensembl: ENSG000001802517   OMIM: 6005315   UniProtKB: Q6AI143   

Export aliases for SLC9A4 gene to outside databases

Previous GC identifers: GC02U990082 GC02P102745 GC02P102456 GC02P096854


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SL9A4_HUMAN, Q6AI14
Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse
environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an
important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response
to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride
(EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained
intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in
a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton
and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH,
and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane
may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory
membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell
differentiation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022171.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC9A4 gene promoter:
         AML1a   ATF-2   LCR-F1   AREB6   S8   Nkx6-1   c-Jun   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC9A4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC9A4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC9A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12.1   Ensembl cytogenetic band:  2q12.1   HGNC cytogenetic band: 2q12.1

SLC9A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC9A4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P103089:  view genomic region     (about GC identifiers)

Start:
103,089,762 bp from pter      End:
103,150,431 bp from pter
Size:
60,670 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SL9A4_HUMAN, Q6AI14 (See protein sequence)
Recommended Name: Sodium/hydrogen exchanger 4  
Size: 798 amino acids; 89814 Da
Subunit: Interacts with CHP1 and CHP2 (By similarity)
Subcellular location: Apical cell membrane; Multi-pass membrane protein (By similarity). Basolateral cell membrane;
Multi-pass membrane protein (By similarity). Cytoplasmic granule membrane; Multi-pass membrane protein (By
similarity). Note=Found in zymogen granule membranes (By similarity)
Caution: The number, localization and denomination of hydrophobic domains in the Na(+)/H(+) exchangers vary among
authors
Secondary accessions: Q69YK0

Explore the universe of human proteins at neXtProt for SLC9A4: NX_Q6AI14

Post-translational modifications:

  • May be phosphorylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6AI14

  • SLC9A4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001011552.2  
    ENSEMBL proteins: 
     ENSP00000295269  
    Reactome Protein details: Q6AI14
    Human Recombinant Protein Products: 
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    Uscn Proteins for SLC9A4

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0016323basolateral plasma membrane IEA--
    GO:0016324apical plasma membrane IEA--


    SLC9A4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC9A4


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLC9A4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018422 Cation/H_exchanger_CPA1
     IPR001953 Na/H_exchanger_2
     IPR004709 NaH_exchanger
     IPR006153 Cation/H_exchanger

    Graphical View of Domain Structure for InterPro Entry Q6AI14

    ProtoNet protein and cluster: Q6AI14

    2 Blocks protein families:
    IPB004709 Na+/H+ exchanger signature
    IPB006153 Sodium/hydrogen exchanger


    UniProtKB/Swiss-Prot: SL9A4_HUMAN, Q6AI14
    Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SL9A4_HUMAN, Q6AI14
    Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse
    environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an
    important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response
    to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride
    (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained
    intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in
    a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton
    and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH,
    and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane
    may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory
    membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell
    differentiation (By similarity)

         Genatlas biochemistry entry for SLC9A4:
    solute carrier protein family 9 (sodium/hydrogen exchange),member 4,involved in intracellular pH regulation and cell
    volume,isoform 4,expressed in stomach,kidney,brain,uterus,skeletalmuscle

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    hsa-miR-30c hsa-miR-3607-3p hsa-miR-27a hsa-miR-513a-5p hsa-miR-30d hsa-miR-183* hsa-miR-3168 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidSLC9A4 3' UTR sequence
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015385sodium:hydrogen antiporter activity IEA--


    SLC9A4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Slc9a4tm1Ges for SLC9A4
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc9a4):
     digestive/alimentary  growth/size  immune system 

    SLC9A4 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport1.00
    Transmembrane transport of small molecules0.50
    2Gastric acid secretion
    Gastric acid secretion1.00
    3Sodium/Proton exchangers
    Sodium/Proton exchangers1.00
    4Amino acid and oligopeptide SLC transporters
    Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    5CREB Pathway
    Intracellular Calcium Signaling0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SLC9A4
        Intracellular Calcium Signaling
    PDGF Pathway

    4        Reactome Pathways for SLC9A4
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Sodium/Proton exchangers
    Transport of inorganic cations/anions and amino acids/oligopeptides

    1 PharmGKB Pathway for SLC9A4
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

    1         Kegg Pathway  (Kegg details for SLC9A4):
        Gastric acid secretion


    SLC9A4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC9A4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SLC9A4 (Q6AI143 ENSP000002952694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHP1Q996533, ENSP000003356324I2D: score=2 STRING: ENSP00000335632
    CHP2O437453, ENSP000003001134I2D: score=1 STRING: ENSP00000300113
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006885regulation of pH IEA--
    GO:0055085transmembrane transport TAS--


    SLC9A4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SLC9A4

    1 HMDB Compound for SLC9A4    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--
    Search CenterWatch for drugs/clinical trials and news about SLC9A4 / SL9A4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC9A4 gene: 
    NM_001011552.3  

    Unigene Cluster for SLC9A4:

    Solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
    Hs.447686  [show with all ESTs]
    Unigene Representative Sequence: NM_001011552
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295269(uc002tbz.4) ENST00000492154

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    hsa-miR-30c hsa-miR-3607-3p hsa-miR-27a hsa-miR-513a-5p hsa-miR-30d hsa-miR-183* hsa-miR-3168 hsa-miR-30a
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    Inhib. RNA
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    Additional cDNA sequence: 

    AL833048.1 CR627411.1 

    1 DOTS entry:

    DT.99950666 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC9A4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTCTTTAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SLC9A4 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.447686
        SABiosciences Custom PCR Arrays for SLC9A4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for SLC9A4 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SLC9A41 solute carrier family 9 (sodium/hydrogen exchanger), more 71.58(n)
    73.4(a)
      418718  XM_416917.3  XP_416917.3 
    zebrafish
    (Danio rerio)
    Actinopterygii slc9a26
    solute carrier family 9 (sodium/hydrogen exchanger...
    41(a)
    1 → many
    9(7004555-7033166)
    fruit fly
    (Drosophila melanogaster)
    Insecta Nhe26
    Na[+]/H[+] hydrogen exchanger 2
    19(a)
    1 → many
    2L(21104599-21134255)
    worm
    (Caenorhabditis elegans)
    Secernentea nhx-16
    nhx-26
    (see all 7)
    Na/H eXchanger family member (nhx-2)
    (see all 7)
    35(a)
    34(a)
    (see all 7)
    possible ortholog
    many ↔ many
    (see all 7)
    X(16017447-16021677)
    II(7690656-7693906)
    E. coli
    (Escherichia coli)
    Gamma proteobacteria yjcE6
    predicted cation/proton antiporter
    15(a)
    1 → many
    Chromosome(4278003-4279652)


    ENSEMBL Gene Tree for SLC9A4 (if available)
    TreeFam Gene Tree for SLC9A4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC9A4 gene
    SLC9A62  SLC9A32  SLC9A82  SLC9A12  SLC9A92  SLC9A52  SLC9A22  SLC9A72  
    4 SIMAP similar genes for SLC9A4 using alignment to 1 protein entry:     SL9A4_HUMAN:
    SLC9A2    SLC9A1    SLC9A5    SLC9A3

    SLC9A4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1282 NCBI SNPs in SLC9A4 are shown (see all 1282    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs778201311,2
    C,F,--103087846(+) TGCTGC/TCCTTA 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1154971401,2
    F,--103088081(+) TTTTTA/TCTCTG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs41407861,2
    C,F,A,H,--103088176(-) GTAACA/CCTTTC 1 -- us2k114Minor allele frequency- C:0.49NS EA NA WA CSA 789
    rs1152746301,2
    C,--103088184(+) TACCAA/GGTATG 1 -- us2k10--------
    rs1408593851,2
    --103088255(+) GGTAA-/TTTTTC 1 -- us2k10--------
    rs1849064791,2
    --103088487(+) CTTCTC/TGTAGT 1 -- us2k10--------
    rs41407851,2
    C,F,H,--103088517(-) TTCAGT/GCACTG 1 -- us2k1 tfbs36Minor allele frequency- G:0.24NA WA EA 364
    rs1501615221,2
    --103088541(+) GGAGTC/GAAACT 1 -- us2k10--------
    rs1157257441,2
    F,--103088622(+) TGTTAG/ACCCTT 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs602514891,2
    C--103088669(+) GCTGA-/GTGTG 
     TGTGTGT
    GTGTG
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC9A4 (103089762 - 103150431 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SLC9A4
         1 Indel: 89847

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLC9A4 for disorders           About GeneDecksing

    OMIM gene information: 600531    OMIM disorders: --

    5 diseases for SLC9A4:    About MalaCards
    celiac disease    colon cancer    pneumonia    tuberculosis
    mycobacterium tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: SLC9A4 (1 document)

    Export disorders for SLC9A4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC9A4 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with SLC9A4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal assignment of four genes encoding Na/H ex changer isoforms in human and rat. (PubMed id 8199403)1, 3 Szpirer C....Orlowski J. (1994)
    2. NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells. (PubMed id 17943310)1, 9 Beltran A.R....Malnic G. (2008)
    3. Functional role of NHE4 as a pH regulator in rat and h uman colonic crypts. (PubMed id 22049213)1 Arena E.A....Geibel J.P. (2012)
    4. Identification of nine novel loci associated with whi te blood cell subtypes in a Japanese population. (PubMed id 21738478)1 Okada Y....Kamatani N. (2011)
    5. Newly identified genetic risk variants for celiac disease related to the immune response. (PubMed id 18311140)1 Hunt K.A.... van Heel D.A. (2008)
    6. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)2 Denis N.J.... Figeys D. (2007)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    10. Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium. (PubMed id 12576672)1 Inoue H....Kanazawa H. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 389015 HGNC: 11077 Ensembl:ENSG00000180251 euGenes: HUgn389015 ECgene: SLC9A4 Kegg: 389015
    H-InvDB: SLC9A4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC9A4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC9A4 gene:
    Search GeneIP for patents involving SLC9A4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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