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SLC9A4 Gene

protein-coding   GIFtS: 53
GCID: GC02P103089

Solute Carrier Family 9, Subfamily A (NHE4, Cation Proton...

(Previous names: solute carrier family 9 (sodium/hydrogen exchanger), isoform...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 9, Subfamily A (NHE4, Cation Proton Antiporter
4), Member 41 2
     Na(+)/H(+) Exchanger 42 3
NHE42 3 5     Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 41
Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 41 2     Sodium/Hydrogen Exchanger 42
Solute Carrier Family 9 Member 42 3     Solute Carrier Family 9 (Sodium/Hydrogen Exchanger)2
NHE-42 3     

External Ids:    HGNC: 110771   Entrez Gene: 3890152   Ensembl: ENSG000001802517   OMIM: 6005315   UniProtKB: Q6AI143   

Export aliases for SLC9A4 gene to outside databases

Previous GC identifers: GC02U990082 GC02P102745 GC02P102456 GC02P096854


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC9A4 Gene:
SLC9A4 (solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4) is a protein-coding gene. Diseases associated with SLC9A4 include celiac disease, and pneumonia. GO annotations related to this gene include sodium:hydrogen antiporter activity. An important paralog of this gene is SLC9A3.

UniProtKB/Swiss-Prot: SL9A4_HUMAN, Q6AI14
Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse
environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays
an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in
response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and
ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell
shrinkage in a sustained intracellular acidification-dependence manner. Activated by
4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence
manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral
cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion
in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating
sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal
cell maturation and/or differentiation and at least secondarily for chief cell differentiation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC9A4 gene promoter:
         AML1a   ATF-2   LCR-F1   AREB6   S8   Nkx6-1   c-Jun   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC9A4 promoter sequence
   Search Chromatin IP Primers for SLC9A4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC9A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12.1   Ensembl cytogenetic band:  2q12.1   HGNC cytogenetic band: 2q12.1

SLC9A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC9A4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P103089:  view genomic region     (about GC identifiers)

Start:
103,089,762 bp from pter      End:
103,150,431 bp from pter
Size:
60,670 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SL9A4_HUMAN, Q6AI14 (See protein sequence)
Recommended Name: Sodium/hydrogen exchanger 4  
Size: 798 amino acids; 89814 Da
Subunit: Interacts with CHP1 and CHP2 (By similarity)
Caution: The number, localization and denomination of hydrophobic domains in the Na(+)/H(+) exchangers vary among
authors
Secondary accessions: Q69YK0

Explore the universe of human proteins at neXtProt for SLC9A4: NX_Q6AI14

Explore proteomics data for SLC9A4 at MOPED

Post-translational modifications: 

  • May be phosphorylated (By similarity)1
  • Ubiquitination2 at Lys352
  • Glycosylation2 at Asn342
  • Modification sites at PhosphoSitePlus

  • See SLC9A4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001011552.2  
    ENSEMBL proteins: 
     ENSP00000295269  
    Reactome Protein details: Q6AI14

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Sodium/hydrogen exchanger 4
    SLC9 family of sodium/hydrogen exchangers

    4 InterPro protein domains:
     IPR001953 Na/H_exchanger_2
     IPR006153 Cation/H_exchanger
     IPR018422 Cation/H_exchanger_CPA1
     IPR004709 NaH_exchanger

    Graphical View of Domain Structure for InterPro Entry Q6AI14

    ProtoNet protein and cluster: Q6AI14

    2 Blocks protein domains:
    IPB004709 Na+/H+ exchanger signature
    IPB006153 Sodium/hydrogen exchanger


    UniProtKB/Swiss-Prot: SL9A4_HUMAN, Q6AI14
    Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family


    SLC9A4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SL9A4_HUMAN, Q6AI14
    Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse
    environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays
    an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in
    response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and
    ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell
    shrinkage in a sustained intracellular acidification-dependence manner. Activated by
    4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence
    manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral
    cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion
    in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating
    sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal
    cell maturation and/or differentiation and at least secondarily for chief cell differentiation (By similarity)

         Genatlas biochemistry entry for SLC9A4:
    solute carrier protein family 9 (sodium/hydrogen exchange),member 4,involved in intracellular pH regulation and
    cell volume,isoform 4,expressed in stomach,kidney,brain,uterus,skeletalmuscle

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015299solute:hydrogen antiporter activity ----
    GO:0015385sodium:hydrogen antiporter activity IEA--
         
    SLC9A4 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc9a4):
     digestive/alimentary  growth/size/body  immune system 

    SLC9A4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc9a4tm1Ges for SLC9A4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC9A4
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidSLC9A4 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SL9A4_HUMAN, Q6AI14: Apical cell membrane; Multi-pass membrane protein (By similarity). Basolateral cell
    membrane; Multi-pass membrane protein (By similarity). Cytoplasmic granule membrane; Multi-pass membrane protein
    (By similarity). Note=Found in zymogen granule membranes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0016323basolateral plasma membrane IEA--
    GO:0016324apical plasma membrane IEA--

    SLC9A4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC9A4 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Sodium/Proton exchangers0.00
    2CREB Pathway
    Intracellular Calcium Signaling0.50
    3TCR Signaling (Qiagen)
    PDGF Pathway0.39
    4Salivary secretion
    Gastric acid secretion0.34
    5ADP signalling through P2Y purinoceptor 12
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SLC9A4
        Intracellular Calcium Signaling
    PDGF Pathway

    1 Reactome Pathway for SLC9A4
        Sodium/Proton exchangers

    1 PharmGKB Pathway for SLC9A4
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for SLC9A4):
        Gastric acid secretion


    SLC9A4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC9A4
    Interactions:

        Search GeneGlobe Interaction Network for SLC9A4

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for SLC9A4 (Q6AI143 ENSP000002952694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHP1Q996533, ENSP000003356324I2D: score=2 STRING: ENSP00000335632
    CHP2O437453, ENSP000003001134I2D: score=1 STRING: ENSP00000300113
    BRAPENSP000003308134STRING: ENSP00000330813
    TMCO3ENSP000003893994STRING: ENSP00000389399
    TNFRSF1AENSP000001627494STRING: ENSP00000162749
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006812cation transport ----
    GO:0006814sodium ion transport ----
    GO:0006885regulation of pH IEA--
    GO:0055085transmembrane transport TAS--

    SLC9A4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC9A4 (SL9A4)

    1 HMDB Compound for SLC9A4    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC9A4 gene: 
    NM_001011552.3  

    Unigene Cluster for SLC9A4:

    Solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
    Hs.447686  [show with all ESTs]
    Unigene Representative Sequence: NM_001011552
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295269(uc002tbz.4) ENST00000492154
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat SLC9A4

    Additional mRNA sequence: 

    AL833048.1 CR627411.1 

    1 DOTS entry:

    DT.99950666 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC9A4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCTTTAAA
    SLC9A4 Expression
    About this image

    SLC9A4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC9A4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.447686
        Custom PCR Arrays for SLC9A4
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC9A4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc9a41 , 5 solute carrier family 9 (sodium/hydrogen exchanger), more1, 5 82.79(n)1
    83.54(a)1
      1 (19.51 cM)5
    1108951  NM_177084.31  NP_796058.11 
     405802275 
    chicken
    (Gallus gallus)
    Aves SLC9A41 solute carrier family 9, subfamily A (NHE4, cation more 71.84(n)
    73.82(a)
      418718  NM_001257255.1  NP_001244184.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Sodium/hydrogen exchanger
    51(a)
    many ↔ many
    GL343202.1(75265-96590)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc9a41 solute carrier family 9, subfamily A (NHE4, cation more 66.99(n)
    67.25(a)
      100491047  XM_002934502.2  XP_002934548.2 
    zebrafish
    (Danio rerio)
    Actinopterygii slc9a26
    solute carrier family 9 (sodium/hydrogen exchanger...
    42(a)
    1 → many
    9(7004555-7033166) ENSDARG00000058780
    fruit fly
    (Drosophila melanogaster)
    Insecta Nhe26
    Na[+]/H[+] hydrogen exchanger 2
    22(a)
    1 → many
    2L(21104599-21134255)
    worm
    (Caenorhabditis elegans)
    Secernentea nhx-16
    nhx-96
    (see all 5)
    Protein NHX-9, isoform b
    (see all 5)
    35(a)
    35(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    X(16017518-16021748) WBGene00003729
    IV(11930872-11935714) WBGene00003736


    ENSEMBL Gene Tree for SLC9A4 (if available)
    TreeFam Gene Tree for SLC9A4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC9A4 gene
    SLC9A32  SLC9A62  SLC9A82  SLC9A12  SLC9A92  SLC9A52  SLC9A22  SLC9A72  
    4 SIMAP similar genes for SLC9A4 using alignment to 1 protein entry:     SL9A4_HUMAN:
    SLC9A2    SLC9A1    SLC9A5    SLC9A3

    SLC9A4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC9A4 (see all 1527)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs778201311,2
    C,F--103087846(+) TGCTGC/TCCTTA 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1154971401,2
    F--103088081(+) TTTTTA/TCTCTG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs41407861,2
    C,F,A,H--103088176(-) GTAACA/CCTTTC 1 -- us2k114Minor allele frequency- C:0.49NS EA NA WA CSA 789
    rs1152746301,2
    C--103088184(+) TACCAA/GGTATG 1 -- us2k10--------
    rs1408593851,2
    --103088255(+) GGTAA-/TTTTTC 1 -- us2k10--------
    rs1849064791,2
    --103088487(+) CTTCTC/TGTAGT 1 -- us2k10--------
    rs41407851,2
    C,F,H--103088517(-) TTCAGT/GCACTG 1 -- us2k1 tfbs36Minor allele frequency- G:0.24NA WA EA 364
    rs1501615221,2
    --103088541(+) GGAGTC/GAAACT 1 -- us2k10--------
    rs1157257441,2
    C,F--103088622(+) TGTTAG/ACCCTT 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs602514891,2
    C--103088669(+) GCTGA-/GTGTG 
     TGTGTGT
    GTGTG
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC9A4 (103089762 - 103150431 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SLC9A4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667694CNV Deletion23128226
    nsv874754CNV Loss21882294
    nsv523406CNV Loss19592680
    nsv874755CNV Gain21882294

    Human Gene Mutation Database (HGMD): SLC9A4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC9A4
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC9A4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 600531    OMIM disorders: --

    3 diseases for SLC9A4:    
    About MalaCards
    celiac disease    pneumonia    tuberculosis


    SLC9A4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC9A4
    Human Genome Epidemiology (HuGE) Navigator: SLC9A4 (1 document)

    Export disorders for SLC9A4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC9A4 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with SLC9A4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PubMed id 21738478)1, 4 Okada Y....Kamatani N. (PLoS Genet. 2011)
    2. Newly identified genetic risk variants for celiac disease related to the immune response. (PubMed id 18311140)1, 4 Hunt K.A.... van Heel D.A. (Nat. Genet. 2008)
    3. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (Proteomics 2007)
    4. Chromosomal assignment of four genes encoding Na/H exchanger isoforms in human and rat. (PubMed id 8199403)1, 3 Szpirer C....Orlowski J. (Mamm. Genome 1994)
    5. NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells. (PubMed id 17943310)1, 9 BeltrA!n A.R....Malnic G. (Pflugers Arch. 2008)
    6. Functional role of NHE4 as a pH regulator in rat and human colonic crypts. (PubMed id 22049213)1 Arena E.A....Geibel J.P. (Am. J. Physiol., Cell Physiol. 2012)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    10. Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium. (PubMed id 12576672)1 Inoue H....Kanazawa H. (amp 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 389015 HGNC: 11077 Ensembl:ENSG00000180251 euGenes: HUgn389015 ECgene: SLC9A4 Kegg: 389015
    H-InvDB: SLC9A4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLC9A4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLC9A4 gene:
    Search GeneIP for patents involving SLC9A4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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