Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC9A3 Gene

protein-coding   GIFtS: 61
GCID: GC05M000473

solute carrier family 9, subfamily A (NHE3, cation proton...

(Previous names: solute carrier family 9 (sodium/hydrogen exchanger), isoform...)
(Previous symbol: NHE3)
 Explore 27 diseases affiliated with
SLC9A3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC9A3    

Aliases
for SLC9A3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 9, Subfamily A (NHE3, Cation Proton Antiporter 3),
Member 31 2
     Na(+)/H(+) Exchanger 32 3
NHE31 2 3 5     Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 31
Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 31 2     Sodium/Hydrogen Exchanger 32
Solute Carrier Family 9 Member 32 3     Solute Carrier Family 9 (Sodium/Hydrogen Exchanger)2
NHE-32 3     

External Ids:    HGNC: 110731   Entrez Gene: 65502   Ensembl: ENSG000000662307   OMIM: 1823075   UniProtKB: P487643   

Export aliases for SLC9A3 gene to outside databases

Previous GC identifers: GC05M000647 GC05M000513 GC05M000526 GC05M000460


Summaries
for SLC9A3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SL9A3_HUMAN, P48764
Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse
environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an
important role in signal transduction

Gene Wiki entry for SLC9A3 (Sodiumâ€"hydrogen antiporter 3)


Genomic Views
for SLC9A3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC9A3 gene promoter:
         AP-2alpha isoform 3   STAT3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC9A3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC9A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC9A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.3   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15.3

SLC9A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC9A3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M000473:  view genomic region     (about GC identifiers)

Start:
 473,334 bp from pter      End:
 524,549 bp from pter
Size:
 51,216 bases      Orientation:
 minus strand

Proteins
for SLC9A3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SL9A3_HUMAN, P48764 (See protein sequence)
Recommended Name: Sodium/hydrogen exchanger 3  
Size: 834 amino acids; 92855 Da
Subunit: Binds SLC9A3R1 and SLC9A3R2. Interacts with CHP1, CHP2 and SHANK2. Interacts with PDZD3 and interactions
decrease in response to elevated calcium ion levels (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=In intestinal epithelial cells, localizes to the
ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane
Caution: The number, localization and denomination of hydrophobic domains in the Na(+)/H(+) exchangers vary among
authors
Secondary accessions: Q3MIW3

Explore the universe of human proteins at neXtProt for SLC9A3: NX_P48764

Post-translational modifications:

  • Phosphorylated by PKA, which inhibits activity (By similarity). Phosphorylation at Ser-663 by SGK1 is associated with
    • increased abundance at the cell membrane (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P48764

    • SLC9A3 Protein expression data from MOPED and PaxDb:    About this image 
    SLC9A3 Protein Expression
    REFSEQ proteins: NP_004165.2  
    ENSEMBL proteins: 
     ENSP00000264938   ENSP00000422983  
    Reactome Protein details: P48764
    Human Recombinant Protein Products for SLC9A3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SLC9A3
    OriGene Custom Protein Services for SLC9A3 
    GenScript Custom Purified and Recombinant Proteins Services for SLC9A3
    Novus Biologicals SLC9A3 Protein
    Novus Biologicals SLC9A3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC9A3

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005903brush border ISS--
    GO:0009986cell surface ISS--
    GO:0016021integral to membrane IEA--
    GO:0016324apical plasma membrane IEA--

    SLC9A3 for ontologies           About GeneDecksing



    SLC9A3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SLC9A3
    Browse R&D Systems for Antibodies
    OriGene Antibodies: SLC9A3
    OriGene Custom Antibody Services for SLC9A3 
    GenScript Custom Superior Antibodies Services for SLC9A3
    Novus Biologicals SLC9A3 Antibodies
    Abcam antibodies for SLC9A3 
    Uscn Antibodies for SLC9A3
    ThermoFisher Antibodies for SLC9A3

    Assay Products for SLC9A3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC9A3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SLC9A3

    Protein Domains /
    Families
    for SLC9A3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC9A3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018422 Cation/H_exchanger_CPA1
     IPR018410 Na/H_exchanger_3/5
     IPR004709 NaH_exchanger
     IPR006153 Cation/H_exchanger

    Graphical View of Domain Structure for InterPro Entry P48764

    ProtoNet protein and cluster: P48764

    4 Blocks protein families:
    IPB001118 Na+/H+ exchanger isoform 3 (NHE3) signature
    IPB001680 G-protein beta WD-40 repeat signature
    IPB004709 Na+/H+ exchanger signature
    IPB006153 Sodium/hydrogen exchanger


    UniProtKB/Swiss-Prot: SL9A3_HUMAN, P48764
    Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family


    Function
    for SLC9A3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SL9A3_HUMAN, P48764
    Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse
    environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an
    important role in signal transduction

         Genatlas biochemistry entry for SLC9A3:
    solute carrier protein family 9 (sodium/hydrogen exchange),member 3,involved in intracellular pH regulation and cell
    volume,isoform 3B,apical epithelium,expressed in kidney,gastrointestinal tract (amiloride insensitive)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19088451
    GO:0015385sodium:hydrogen antiporter activity ISS--
         
    SLC9A3 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc9a3):
     cardiovascular system  digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism  renal/urinary system 
     reproductive system 

    SLC9A3 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Slc9a3tm1Ges for SLC9A3
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC9A3 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SLC9A3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC9A3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SLC9A3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC9A3 (see all 7)
    OriGene shRNA RFP: SLC9A3
    OriGene siRNA: SLC9A3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC9A3
    Sirion Biotech Custom design and validation of potent shRNA sequences against SLC9A3 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SLC9A3
    Sirion Biotech Customized adenovirus for overexpression of SLC9A3 
    Sirion Biotech Customized adenovirus for potent knockdown of SLC9A3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SLC9A3 (NM_004174)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC9A3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9A3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SLC9A3
    Search LifeMap BioReagents cell lines for SLC9A3
    Sirion Biotech Customized stable knockdown cell line services for SLC9A3 
    Sirion Biotech Customized inducible knockdown cell line services for SLC9A3
    Sirion Biotech Customized stable overexpressing cell line services for SLC9A3
    Sirion Biotech Customized inducible overexpressing cell line services for SLC9A3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A3


    Pathways & Interactions
    for SLC9A3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50
    2SIDS Susceptibility Pathways
    		SIDS Susceptibility Pathways1.00
    3G12-G13 in Cellular Signaling
    		G12-G13 in Cellular Signaling1.00
    4RhoA signaling pathway
    		RhoA signaling pathway1.00
    5Endothelins
    		Endothelins1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SLC9A3
        G12-G13 in Cellular Signaling
    Intracellular Calcium Signaling
    PDGF Pathway

    3 BioSystems Pathways for SLC9A3 
        SIDS Susceptibility Pathways
    RhoA signaling pathway
    Endothelins

    4        Reactome Pathways for SLC9A3
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Sodium/Proton exchangers
    Transport of inorganic cations/anions and amino acids/oligopeptides

    1 PharmGKB Pathway for SLC9A3
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

    4         Kegg Pathways  (Kegg details for SLC9A3):
        Proximal tubule bicarbonate reclamation
    Protein digestion and absorption
    Bile secretion
    Mineral absorption


    SLC9A3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC9A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for SLC9A3 (P487642, 3 ENSP000002649384) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAST2Q6P0Q82, 3, ENSP000003546714MINT-1892413 MINT-1892385 I2D: score=2 STRING: ENSP00000354671
    CHP1Q996533, ENSP000003356324I2D: score=2 STRING: ENSP00000335632
    SLC9A3R1O147453, ENSP000002626134I2D: score=2 STRING: ENSP00000262613
    CHP2O437453, ENSP000003001134I2D: score=2 STRING: ENSP00000300113
    LRP2P981643, ENSP000002638164I2D: score=1 STRING: ENSP00000263816
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002028regulation of sodium ion transport ----
    GO:0006811ion transport TAS--
    GO:0006814sodium ion transport ----
    GO:0006885regulation of pH IEA--
    GO:0006898receptor-mediated endocytosis ----

    SLC9A3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC9A3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC9A3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC9A3

    1 HMDB Compound for SLC9A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--
    10/60 Novoseek chemical compound relationships for SLC9A3 gene (see all 60)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hoe 694 88.3 5 16564041 (2), 8743940 (1), 9560454 (1), 11698229 (1)
    eipa 84.9 20 7631739 (2), 9421479 (1), 12911544 (1), 14586169 (1) (see all 11)
    sulfosuccinimidyl acetate 79 4 11133512 (1), 15942046 (1)
    glycylsarcosine 73.9 9 16415530 (3), 17182800 (1)
    hoe-642 71.2 3 12911544 (1)
    amiloride 68.9 16 8415663 (2), 8246907 (2), 11408268 (2), 9425602 (1) (see all 9)
    sodium 59.9 41 18785066 (3), 12955677 (2), 16103375 (2), 10966919 (2) (see all 26)
    cariporide 56.7 4 12911544 (1), 19302267 (1)
    bicarbonate 55.7 11 17882150 (1), 11875004 (1), 16715296 (1), 15365806 (1) (see all 8)
    nacl 49.9 13 18785066 (2), 10428871 (1), 16715296 (1), 11181400 (1) (see all 11)

    Search CenterWatch for drugs/clinical trials and news about SLC9A3 / SL9A3 

    Transcripts
    for SLC9A3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC9A3 gene: 
    NM_004174.2  

    Unigene Cluster for SLC9A3:

    Solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
    Hs.658120  [show with all ESTs]
    Unigene Representative Sequence: NM_004174
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264938(uc003jbe.2 uc011clx.1) ENST00000514375 ENST00000507407


    miRNA
    Products:             		 OriGene 3'-UTR Clone: SLC9A3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC9A3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SLC9A3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC9A3 (see all 7)
    OriGene shRNA RFP: SLC9A3
    OriGene siRNA: SLC9A3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC9A3
    Sirion Biotech Custom design and validation of potent shRNA sequences against SLC9A3 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SLC9A3 (NM_004174)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC9A3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9A3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC9A3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC9A3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC9A3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC9A3

    Additional cDNA sequence: 

    BC011555.1 BC101669.1 BC101671.1 BC143328.1 S83545.1 U28043.1 

    4 DOTS entries:

    DT.106162  DT.95249311  DT.99971018  DT.97822279 

    7 AceView cDNA sequences:

    AA295852 NM_004174 S83545 U28043 BC011555 BG333089 AW963753 

    GeneLoc Exon Structure


    Expression
    for SLC9A3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC9A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    SLC9A3 Expression
    About this image

    SLC9A3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyLoop of HenleLoop of Henle CellsKidney
    KidneyProximal TubuleProximal Tubule CellsKidney
    OvaryPrimary FollicleGranulosa CellsOvary
    OvaryPrimordial FolliclePre-Granulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC9A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC9A3

    SOURCE GeneReport for Unigene cluster: Hs.658120
        SABiosciences Expression via Pathway-Focused PCR Arrays including SLC9A3: 
              Circadian Rhythms in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Osmotic Stress in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC9A3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC9A3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC9A3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC9A3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A3

    Orthologs
    for SLC9A3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for SLC9A3 gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Slc9a31 , 5 solute carrier family 9 (sodium/hydrogen exchanger), more1, 5 83.5(n)1
    90.17(a)1    		   13 (40.15 cM)5
    1052431  NM_001081060.11  NP_001074529.11 
     741215155 
    chicken
    (Gallus gallus)    		 Aves SLC9A31 solute carrier family 9 (sodium/hydrogen exchanger), more 70.13(n)
    81.28(a)    		   420801  XM_418895.2  XP_418895.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC9A36
    		 --
    		 75(a)
    		 1 ↔ 1
    		 6(56341685-56400690)
    zebrafish
    (Danio rerio)    		 Actinopterygii slc9a3.11 solute carrier family 9 (sodium/hydrogen exchanger), more 60.66(n)
    55.19(a)    		   568258  NM_001113473.1  NP_001106944.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Nhe21 Na[+]/H[+] hydrogen exchanger 2 53.81(n)
    47.53(a)    		   35376  NM_001144379.2  NP_001137851.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea nhx-93
    nhx-31    		 Na(+)/H(+) antiporter3
    Protein NHX-31    		 45(a)
    (best of 5)3
    51.04(n)1
    46.46(a)1    		   IV(11931047-11935802)3
    1838111  NM_001028564.11  NP_001023735.11 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria yjcE6
    		 predicted cation/proton antiporter
    		 14(a)
    		 1 → many
    		 Chromosome(4278003-4279652)


    ENSEMBL Gene Tree for SLC9A3 (if available)
    TreeFam Gene Tree for SLC9A3 (if available) 

    Paralogs
    for SLC9A3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC9A3 gene
    SLC9A62  SLC9A42  SLC9A82  SLC9A12  SLC9A92  SLC9A52  SLC9A22  SLC9A72  
    6 SIMAP similar genes for SLC9A3 using alignment to 3 protein entries:     SL9A3_HUMAN (see all proteins):
    Na+/H+ exchanger isoform NHE-3    SLC9A5    SLC9A4    SLC9A2    SLC9A1    SLC9A8

    SLC9A3 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for SLC9A3
    PGOHUM00000238486 PGOHUM00000238776 PGOHUM00000238793 PGOHUM00000246416


    Genomic Variants
    for SLC9A3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1422 NCBI SNPs in SLC9A3 are shown (see all 1422)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs104747831,2
    		--460884(+) GTCCCC/TGAGCC 1 -- int10--------
    rs125146271,2
    		H--460967(+) GGTTCA/GCGGGG 1 -- int10--------
    rs745793201,2
    		--461100(+) GGTCAA/GGGTCC 1 -- int12Minor allele frequency- G:0.06CSA NA 121
    rs133549351,2
    		C,F--461283(+) GGGTCG/AGGGAC 1 -- int12Minor allele frequency- A:0.06NA EA 240
    rs727006881,2
    		C--461395(+) CAGGCG/CGCCCT 1 -- int12Minor allele frequency- C:0.24NA 122
    rs558981981,2
    		C--462468(+) GCCTT-/GGAAAGTT
    AGGGTCACCG    GGAAG     		2 -- nc-transcript-variant0--------
    rs560931081,2
    		C--462472(+) TGGAAA/GGTTAG 1 -- nc-transcript-variant0--------
    rs117459231,2
    		C,F,H--462538(+) ATCCAT/GGACCC 1 -- nc-transcript-variant1Minor allele frequency- G:0.38NA 120
    rs117438251,2
    		C,F,H--462593(+) CATACC/TCCACC 1 -- int11Minor allele frequency- T:0.38NA 120
    rs781589481,2
    		--462739(+) ATGACC/TGAGCT 1 -- int12Minor allele frequency- T:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for SLC9A3 (473334 - 524549 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 24 variations for SLC9A3
         8 CNVs: 4228 64075 51717 99031 3536 4427 8476 99032
         15/16 Indels (see all 16): 68933 33403 40724 68932 43204 41585 27959 27955 27961 42647 27957 40723 33402 33404 68935

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC9A3
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC9A3

    Disorders / Diseases
    for SLC9A3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC9A3 for disorders           About GeneDecksing

    OMIM gene information: 182307    OMIM disorders: --

    20/27 diseases for SLC9A3 (see all 27):    About MalaCards
    sudden infant death syndrome    renal tubular acidosis    inflammatory bowel disease    febrile seizures
    short bowel syndrome    cystic fibrosis    pulmonary function    diabetes mellitus
    essential hypertension    leptospirosis    nephropathy    seizures
    epididymitis    fibrosis    colon adenocarcinoma    diarrhea
    duodenitis    aldosteronism    adenoma    hypertension

    10/14 Novoseek disease relationships for SLC9A3 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metabolic acidosis 31 6 12027224 (2), 9261983 (2), 8743473 (1)
    cystic fibrosis 26.7 7 16421216 (2), 17504921 (1), 19447883 (1), 11875260 (1) (see all 6)
    acidosis 25.5 2 15496145 (1), 9690205 (1)
    hypokalemia 20.3 2 10069999 (1), 14752245 (1)
    adenoma 18.9 7 10428871 (1), 16715296 (1), 19447883 (1), 12369822 (1) (see all 6)
    inflammatory bowel diseases 17.5 1 16760259 (1)
    diabetic nephropathies 15.9 1 18238849 (1)
    renal failure 0 1 17487471 (1)
    proteinuria 0 1 12799307 (1)
    colon cancer 0 2 11193592 (1), 8626628 (1)

    Genetic Association Database (GAD): SLC9A3
    Human Genome Epidemiology (HuGE) Navigator: SLC9A3 (9 documents)

    Export disorders for SLC9A3 gene to outside databases

    Publications
    for SLC9A3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC9A3 gene, integrated from 9 sources (see all 271):
    (articles sorted by number of sources associating them with SLC9A3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3. (PubMed id 7631746)1, 2, 9 Brant S.R.... Tse C.-M. (1995)
    2. Physical and genetic mapping of a human apical epithelial Na+/H+ exchanger (NHE3) isoform to chromosome 5p15.3. (PubMed id 8096830)1, 3, 9 Brant S.R....Tse C.M. (1993)
    3. Molecular variants of the sodium/hydrogen exchanger type 3 gene and essential hypertension. (PubMed id 15201541)1, 4, 9 Zhu H....MacGregor G.A. (2004)
    4. Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism. (PubMed id 19088451)1, 2 Zachos N.C.... Donowitz M. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Casein kinase 2 binds to the C terminus of Na+/H+ exchanger 3 (NHE3) and stimulates NHE3 basal activity by phosphorylating a separate site in NHE3. (PubMed id 18614797)1, 9 Sarker R....Li X. (2008)
    7. Cyclic AMP-mediated endocytosis of intestinal epithel ial NHE3 requires binding to synaptotagmin 1. (PubMed id 19926819)1, 9 Musch M.W....Chang E.B. (2010)
    8. Angiotensin II directly regulates intestinal epithelial NHE3 in Caco2BBE cells. (PubMed id 19338654)1, 9 Musch M.W....Chang E.B. (2009)
    9. Acute activation of NHE3 by dexamethasone correlates with activation of SGK1 and requires a functional glucocorticoid receptor. (PubMed id 16971495)1, 9 Wang D....Yun C.C. (2007)
    10. Involvement of Sp1 and Sp3 in differential regulation of human NHE3 promoter activity by sodium butyrate and IFN-gamma/TNF-alpha. (PubMed id 17540780)1, 9 Amin M.R....Malakooti J. (2007)

    External Searches for SLC9A3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SLC9A3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6550 HGNC: 11073 AceView: SLC9A3 Ensembl:ENSG00000066230 euGenes: HUgn6550
    ECgene: SLC9A3 Kegg: 6550 H-InvDB: SLC9A3

    Other Databases showing SLC9A3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC9A3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC9A3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC9A3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC9A3 gene:
    Search GeneIP for patents involving SLC9A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SLC9A3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SLC9A3
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for SLC9A3   OriGene shRNA RFP for SLC9A3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC9A3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC9A3  
     OriGene Protein Over-expression Lysate for SLC9A3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SLC9A3   OriGene 3'-UTR Clone for SLC9A3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC9A3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC9A3   OriGene Custom Protein Services for SLC9A3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC9A3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC9A3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC9A3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC9A3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC9A3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC9A3
     GenScript Custom Purified and Recombinant Proteins Services for SLC9A3 GenScript cDNA clones with any tag delivered in your preferred vector for SLC9A3
     GenScript Custom Assay Services for SLC9A3 GenScript Custom Superior Antibodies Services for SLC9A3
     GenScript Custom overexpressing Cell Line Services for SLC9A3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SLC9A3 promoter
     Search Chromatin IP Primers for SLC9A3
     RT2 qPCR Primer Assay in human, mouse, rat SLC9A3
     GNC Network for SLC9A3
     SABiosciences PCR Arrays including human, mouse, rat SLC9A3
     Search Tocris compounds for SLC9A3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SLC9A3 antibodies
     SLC9A3 proteins
     SLC9A3 lysates
     Antibodies for SLC9A3
     See all of Abcam's Antibodies, Kits and Proteins for SLC9A3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SLC9A3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SLC9A3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SLC9A3
     SwitchGear Promoter luciferase reporter plasmids for SLC9A3
     ThermoFisher Antibodies for SLC9A3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC9A3
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC9A3
    Sirion Biotech Customized:
     stable knockdown cell line services for SLC9A3
     inducible knockdown cell line services for SLC9A3
     design and validation of potent shRNA sequences against SLC9A3
     adenovirus for potent knockdown of SLC9A3
     adenovirus for overexpression of SLC9A3
     stable overexpressing cell line services for SLC9A3
     inducible overexpressing cell line services for SLC9A3
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SLC9A3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4