Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC9A2 Gene

Aliases for SLC9A2 Gene

  • Solute Carrier Family 9, Subfamily A (NHE2, Cation Proton Antiporter 2), Member 2 2 3
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 2 2 3
  • Solute Carrier Family 9 Member 2 3 4
  • Na(+)/H(+) Exchanger 2 3 4
  • NHE2 3 4
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 2 2
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger) 3
  • Sodium/Hydrogen Exchanger 2 3
  • NHE-2 4

External Ids for SLC9A2 Gene

Previous HGNC Symbols for SLC9A2 Gene

  • NHE2

Previous GeneCards Identifiers for SLC9A2 Gene

  • GC02P101100
  • GC02P101688
  • GC02P102840
  • GC02P102857
  • GC02P103236
  • GC02P097000

Summaries for SLC9A2 Gene

GeneCards Summary for SLC9A2 Gene

SLC9A2 (Solute Carrier Family 9, Subfamily A (NHE2, Cation Proton Antiporter 2), Member 2) is a Protein Coding gene. Diseases associated with SLC9A2 include proximal renal tubular acidosis. Among its related pathways are CREB Pathway and G12-G13 in Cellular Signaling. GO annotations related to this gene include sodium:proton antiporter activity. An important paralog of this gene is SLC9A4.

UniProtKB/Swiss-Prot for SLC9A2 Gene

  • Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption

Gene Wiki entry for SLC9A2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC9A2 Gene

Genomics for SLC9A2 Gene

Regulatory Elements for SLC9A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC9A2 Gene

Start:
102,619,707 bp from pter
End:
102,711,350 bp from pter
Size:
91,644 bases
Orientation:
Plus strand

Genomic View for SLC9A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC9A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC9A2 Gene

Proteins for SLC9A2 Gene

  • Protein details for SLC9A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBY0-SL9A2_HUMAN
    Recommended name:
    Sodium/hydrogen exchanger 2
    Protein Accession:
    Q9UBY0
    Secondary Accessions:
    • B2RMS2

    Protein attributes for SLC9A2 Gene

    Size:
    812 amino acids
    Molecular mass:
    91520 Da
    Quaternary structure:
    • Interacts with CHP1 and CHP2.

neXtProt entry for SLC9A2 Gene

Proteomics data for SLC9A2 Gene at MOPED

Post-translational modifications for SLC9A2 Gene

Other Protein References for SLC9A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC9A2 Gene

Domains for SLC9A2 Gene

Gene Families for SLC9A2 Gene

Suggested Antigen Peptide Sequences for SLC9A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBY0

UniProtKB/Swiss-Prot:

SL9A2_HUMAN :
  • Q9UBY0
Family:
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
genes like me logo Genes that share domains with SLC9A2: view

Function for SLC9A2 Gene

Molecular function for SLC9A2 Gene

GENATLAS Biochemistry:
solute carrier protein family 9 (sodium/hydrogen exchange),member 4,,involved in intracellular pH regulation and cell volume,isoform 2 (amiloride sensitive),expressed in brain,intestinal villi,distal convoluted tubules and other tissues
UniProtKB/Swiss-Prot Function:
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption

Gene Ontology (GO) - Molecular Function for SLC9A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015299 solute:proton antiporter activity --
GO:0015385 sodium:proton antiporter activity IEA --
genes like me logo Genes that share ontologies with SLC9A2: view
genes like me logo Genes that share phenotypes with SLC9A2: view

Animal Models for SLC9A2 Gene

MGI Knock Outs for SLC9A2:

Animal Model Products

CRISPR Products

miRNA for SLC9A2 Gene

miRTarBase miRNAs that target SLC9A2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC9A2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC9A2 Gene

Localization for SLC9A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC9A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC9A2 Gene COMPARTMENTS Subcellular localization image for SLC9A2 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SLC9A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC9A2: view

Pathways for SLC9A2 Gene

genes like me logo Genes that share pathways with SLC9A2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SLC9A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006812 cation transport --
GO:0006814 sodium ion transport --
GO:0006885 regulation of pH IEA --
GO:0008104 protein localization IEA --
genes like me logo Genes that share ontologies with SLC9A2: view

Compounds for SLC9A2 Gene

(1) HMDB Compounds for SLC9A2 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5

(9) Novoseek inferred chemical compound relationships for SLC9A2 Gene

Compound -log(P) Hits PubMed IDs
eipa 83 1
amiloride 74.4 9
cariporide 71.6 1
butyrate 35.6 1
bicarbonate 29.3 1
genes like me logo Genes that share compounds with SLC9A2: view

Transcripts for SLC9A2 Gene

mRNA/cDNA for SLC9A2 Gene

(7) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC9A2 Gene

Solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC9A2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC9A2 Gene

No ASD Table

Relevant External Links for SLC9A2 Gene

GeneLoc Exon Structure for
SLC9A2
ECgene alternative splicing isoforms for
SLC9A2

Expression for SLC9A2 Gene

mRNA expression in normal human tissues for SLC9A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC9A2 Gene

This gene is overexpressed in Colon - Transverse (14.8) and Stomach (9.0).

Protein differential expression in normal tissues for SLC9A2 Gene

This gene is overexpressed in Colon (51.9) and Fetal Brain (17.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC9A2 Gene

SOURCE GeneReport for Unigene cluster for SLC9A2 Gene Hs.250083

mRNA Expression by UniProt/SwissProt for SLC9A2 Gene

Q9UBY0-SL9A2_HUMAN
Tissue specificity: Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine
genes like me logo Genes that share expressions with SLC9A2: view

Expression partners for SLC9A2 Gene

In Situ Assay Products

Orthologs for SLC9A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC9A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC9A2 35
  • 86.01 (n)
  • 91.6 (a)
SLC9A2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC9A2 35
  • 89.39 (n)
  • 93.3 (a)
SLC9A2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc9a2 35
  • 84.81 (n)
  • 91.13 (a)
Slc9a2 16
Slc9a2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC9A2 35
  • 99.71 (n)
  • 99.75 (a)
SLC9A2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc9a2 35
  • 84.01 (n)
  • 91 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC9A2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC9A2 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC9A2 35
  • 74.17 (n)
  • 79.92 (a)
SLC9A2 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC9A2 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732511 35
  • 70.24 (n)
  • 74.73 (a)
zebrafish
(Danio rerio)
Actinopterygii slc9a2 35
  • 58.53 (n)
  • 53.4 (a)
slc9a2 36
  • 44 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Nhe2 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nhx-2 37
  • 42 (a)
nhx-3 37
  • 43 (a)
nhx-6 37
  • 40 (a)
nhx-7 37
  • 35 (a)
nhx-9 37
  • 45 (a)
nhx-1 36
  • 39 (a)
ManyToMany
nhx-2 36
  • 36 (a)
ManyToMany
nhx-3 36
  • 35 (a)
ManyToMany
nhx-6 36
  • 36 (a)
ManyToMany
nhx-9 36
  • 36 (a)
ManyToMany
Species with no ortholog for SLC9A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC9A2 Gene

ENSEMBL:
Gene Tree for SLC9A2 (if available)
TreeFam:
Gene Tree for SLC9A2 (if available)

Paralogs for SLC9A2 Gene

Paralogs for SLC9A2 Gene

Selected SIMAP similar genes for SLC9A2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SLC9A2 Gene

genes like me logo Genes that share paralogs with SLC9A2: view

Variants for SLC9A2 Gene

Sequence variations from dbSNP and Humsavar for SLC9A2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs878539 -- 102,697,289(+) CTTGG(A/G)TTTGG intron-variant
rs887957 -- 102,698,201(-) CTTTT(C/T)TCTAC intron-variant
rs962207 -- 102,681,056(-) atgca(A/G)atttc intron-variant
rs1008397 -- 102,623,529(-) GTGTC(C/T)CACAG intron-variant
rs1011781 -- 102,687,191(-) GTCTC(C/T)GATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC9A2 Gene

Variant ID Type Subtype PubMed ID
esv1033494 CNV Insertion 17803354
esv2584069 CNV Deletion 19546169
esv2417258 CNV Deletion 18987734
nsv214011 CNV Loss 16902084
esv8909 CNV Loss 19470904
esv2720463 CNV Deletion 23290073

Relevant External Links for SLC9A2 Gene

HapMap Linkage Disequilibrium report
SLC9A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC9A2 Gene

Disorders for SLC9A2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SLC9A2 Gene in MalaCards »

(1) Diseases for SLC9A2 Gene including...

(1) University of Copenhagen DISEASES for SLC9A2 Gene

(1) Novoseek inferred disease relationships for SLC9A2 Gene

Disease -log(P) Hits PubMed IDs
adenoma 1.67 1

Relevant External Links for SLC9A2

Genetic Association Database (GAD)
SLC9A2
Human Genome Epidemiology (HuGE) Navigator
SLC9A2
genes like me logo Genes that share disorders with SLC9A2: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for SLC9A2 Gene

Publications for SLC9A2 Gene

  1. Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2. (PMID: 10444453) Malakooti J. … Ramaswamy K. (Am. J. Physiol. 1999) 3 4 23
  2. The human Na(+)/H(+) exchanger NHE2 gene: genomic organization and promoter characterization. (PMID: 11254504) Malakooti J. … Ramaswamy K. (Am. J. Physiol. Gastrointest. Liver Physiol. 2001) 3 23
  3. NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells. (PMID: 17943310) BeltrA!n A.R. … Malnic G. (Pflugers Arch. 2008) 3 23
  4. Morphological adaptation with preserved proliferation/transporter content in the colon of patients with short bowel syndrome. (PMID: 19389806) Joly F. … Thomas M. (Am. J. Physiol. Gastrointest. Liver Physiol. 2009) 3 23
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for SLC9A2 Gene

Sources for SLC9A2 Gene

Back to Top

Content