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SLC9A2 Gene

protein-coding   GIFtS: 62
GCID: GC02P103236

Solute Carrier Family 9, Subfamily A (NHE2, Cation Proton...

(Previous names: solute carrier family 9 (sodium/hydrogen exchanger), isoform...)
(Previous symbol: NHE2)
  Search for SLC9A2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 9, Subfamily A (NHE2, Cation Proton Antiporter
2), Member 21 2
     Na(+)/H(+) Exchanger 22 3
NHE21 2 3     Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 21
Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 21 2     Sodium/Hydrogen Exchanger 22
Solute Carrier Family 9 Member 22 3     Solute Carrier Family 9 (Sodium/Hydrogen Exchanger)2
NHE-22 3     

External Ids:    HGNC: 110721   Entrez Gene: 65492   Ensembl: ENSG000001156167   OMIM: 6005305   UniProtKB: Q9UBY03   

Export aliases for SLC9A2 gene to outside databases

Previous GC identifers: GC02P101100 GC02P101688 GC02P102840 GC02P102857 GC02P102694 GC02P097000


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC9A2 Gene:
SLC9A2 (solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2) is a protein-coding gene. GO annotations related to this gene include sodium:hydrogen antiporter activity. An important paralog of this gene is SLC9A3.

UniProtKB/Swiss-Prot: SL9A2_HUMAN, Q9UBY0
Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse
environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems
to play an important role in colonic sodium absorption

Gene Wiki entry for SLC9A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC9A2 gene promoter:
         AhR   SRF   NRSF form 1   SRF (504 AA)   Egr-1   AP-2gamma   NRSF form 2   C/EBPalpha   N-Myc   AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC9A2 promoter sequence
   Search Chromatin IP Primers for SLC9A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC9A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q12.1   HGNC cytogenetic band: 2q11.2

SLC9A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC9A2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P103236:  view genomic region     (about GC identifiers)

Start:
103,236,166 bp from pter      End:
103,327,809 bp from pter
Size:
91,644 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SL9A2_HUMAN, Q9UBY0 (See protein sequence)
Recommended Name: Sodium/hydrogen exchanger 2  
Size: 812 amino acids; 91520 Da
Subunit: Interacts with CHP1 and CHP2 (By similarity)
Caution: The number, localization and denomination of hydrophobic domains in the Na(+)/H(+) exchangers vary among
authors
Secondary accessions: B2RMS2

Explore the universe of human proteins at neXtProt for SLC9A2: NX_Q9UBY0

Explore proteomics data for SLC9A2 at MOPED

Post-translational modifications: 

  • Phosphorylated (Possible)1
  • Ubiquitination2 at Lys536
  • Glycosylation2 at Asn350
  • Modification sites at PhosphoSitePlus

  • See SLC9A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003039.2  
    ENSEMBL proteins: 
     ENSP00000233969  
    Reactome Protein details: Q9UBY0

    SLC9A2 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SLC9A2 

    SLC9A2 Antibody Products:

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    Search eBioscience for ELISAs for SLC9A2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Sodium/hydrogen exchanger 2
    SLC9 family of sodium/hydrogen exchangers

    4 InterPro protein domains:
     IPR001953 Na/H_exchanger_2
     IPR006153 Cation/H_exchanger
     IPR018422 Cation/H_exchanger_CPA1
     IPR004709 NaH_exchanger

    Graphical View of Domain Structure for InterPro Entry Q9UBY0

    ProtoNet protein and cluster: Q9UBY0

    3 Blocks protein domains:
    IPB001953 Na+/H+ exchanger isoform 2 (NHE2) signature
    IPB004709 Na+/H+ exchanger signature
    IPB006153 Sodium/hydrogen exchanger


    UniProtKB/Swiss-Prot: SL9A2_HUMAN, Q9UBY0
    Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family


    Find genes that share domains with SLC9A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SL9A2_HUMAN, Q9UBY0
    Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse
    environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems
    to play an important role in colonic sodium absorption

         Genatlas biochemistry entry for SLC9A2:
    solute carrier protein family 9 (sodium/hydrogen exchange),member 4,,involved in intracellular pH regulation and
    cell volume,isoform 2 (amiloride sensitive),expressed in brain,intestinal villi,distal convoluted tubules and
    other tissues

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015299solute:hydrogen antiporter activity ----
    GO:0015385sodium:hydrogen antiporter activity IEA--
         
    Find genes that share ontologies with SLC9A2           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc9a2):
     digestive/alimentary  homeostasis/metabolism  immune system  reproductive system 

    Find genes that share phenotypes with SLC9A2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slc9a2tm1Ges for SLC9A2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC9A2
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    miRNA
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    hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-374a hsa-miR-93 hsa-miR-130b hsa-miR-92b hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidSLC9A2 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC9A2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SL9A2_HUMAN, Q9UBY0: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC9A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC9A2 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Sodium/Proton exchangers0.00
    2CREB Pathway
    Intracellular Calcium Signaling0.50
    3TCR Signaling (Qiagen)
    PDGF Pathway0.39
    4ADP signalling through P2Y purinoceptor 12
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34
    5G12-G13 in Cellular Signaling
    G12-G13 in Cellular Signaling


    Find genes that share SuperPaths with SLC9A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SLC9A2
        G12-G13 in Cellular Signaling
    Intracellular Calcium Signaling
    PDGF Pathway

    1 Reactome Pathway for SLC9A2
        Sodium/Proton exchangers

    1 PharmGKB Pathway for SLC9A2
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC9A2: 
              Osmotic Stress in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLC9A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for SLC9A2 (Q9UBY03 ENSP000002339694) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005193, ENSP000003614234I2D: score=2 STRING: ENSP00000361423
    CHP1Q996533, ENSP000003356324I2D: score=2 STRING: ENSP00000335632
    RASA1P209363, ENSP000002743764I2D: score=2 STRING: ENSP00000274376
    CFTRP135693, ENSP000000030844I2D: score=1 STRING: ENSP00000003084
    PIK3R1P279863, ENSP000002743354I2D: score=1 STRING: ENSP00000274335
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006812cation transport ----
    GO:0006814sodium ion transport ----
    GO:0006885regulation of pH IEA--
    GO:0008104protein localization IEA--

    Find genes that share ontologies with SLC9A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC9A2 (SL9A2)

    1 HMDB Compound for SLC9A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    9 Novoseek inferred chemical compound relationships for SLC9A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    eipa 83 1 7685025 (1)
    amiloride 74.4 12 7685025 (2), 8246907 (2), 11408268 (2), 8569105 (1) (see all 6)
    cariporide 71.6 1 11563929 (1)
    butyrate 35.6 1 11254495 (1)
    bicarbonate 29.3 2 11875004 (1)
    sodium 27.6 2 15709964 (1), 11113072 (1)
    thapsigargin 22.2 1 9730953 (1)
    hydrogen 10.1 1 11113072 (1)
    zinc 0 1 15976391 (1)



    Find genes that share compounds with SLC9A2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC9A2 gene: 
    NM_003048.3  

    Unigene Cluster for SLC9A2:

    Solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
    Hs.250083  [show with all ESTs]
    Unigene Representative Sequence: NM_003048
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233969(uc002tca.3) ENST00000467657 ENST00000469286
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    hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-374a hsa-miR-93 hsa-miR-130b hsa-miR-92b hsa-miR-520b
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      QuantiFast Probe-based Assays in human, mouse, rat SLC9A2

    Additional mRNA sequence: 

    AF073299.1 AK129936.1 BC035787.1 BC136377.1 BC136378.1 S83549.1 

    1 DOTS entry:

    DT.92025487 

    7 AceView cDNA sequences:

    NM_003048 AF073299 BC035787 BX641645 BM544517 AA843986 S83549 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC9A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTTGTGT
    SLC9A2 Expression
    About this image


    SLC9A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Chondrocytes Zeugopod Epiphyseal End
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    SLC9A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC9A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.250083

    UniProtKB/Swiss-Prot: SL9A2_HUMAN, Q9UBY0
    Tissue specificity: Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary,
    and small intestine

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC9A2: 
              Osmotic Stress in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC9A2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc9a21 , 5 solute carrier family 9 (sodium/hydrogen exchanger), more1, 5 84.81(n)1
    91.13(a)1
      1 (19.66 cM)5
    2269991  NM_001033289.21  NP_001028461.21 
     406817125 
    chicken
    (Gallus gallus)
    Aves SLC9A21 solute carrier family 9, subfamily A (NHE2, cation more 74.17(n)
    79.92(a)
      418719  XM_416918.4  XP_416918.4 
    lizard
    (Anolis carolinensis)
    Reptilia SLC9A26
    solute carrier family 9, subfamily A (NHE2, cation...
    74(a)
    1 ↔ 1
    GL343243.1(1436907-1479055)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017325111 sodium/hydrogen exchanger 2-like 70.24(n)
    74.73(a)
      101732511  XM_004911791.1  XP_004911848.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc9a21 solute carrier family 9 (sodium/hydrogen exchanger), more 58.53(n)
    53.4(a)
      562904  NM_001114095.1  NP_001107567.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nhe26
    Na[+]/H[+] hydrogen exchanger 2
    24(a)
    1 → many
    2L(21104599-21134255)
    worm
    (Caenorhabditis elegans)
    Secernentea nhx-93 Na(+)/H(+) antiporter 45(a)
    (best of 5)
      IV(11931047-11935802)   --


    ENSEMBL Gene Tree for SLC9A2 (if available)
    TreeFam Gene Tree for SLC9A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC9A2 gene
    SLC9A32  SLC9A62  SLC9A82  SLC9A12  SLC9A92  SLC9A52  SLC9A72  SLC9A42  
    5 SIMAP similar genes for SLC9A2 using alignment to 1 protein entry:     SL9A2_HUMAN:
    Na+/H+ exchanger isoform NHE-2    SLC9A4    SLC9A1    SLC9A5    SLC9A3

    Find genes that share paralogs with SLC9A2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SLC9A2
    PGOHUM00000241874


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC9A2 (see all 1978)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359654
    A breast cancer sample4--see VAR_0359652 R Q mis40--------
    VAR_0359644
    A breast cancer sample4--see VAR_0359642 T S mis40--------
    rs1150906151,2
    C,F--96998504(+) CTCCAC/TTGCTT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs570123901,2
    C--97060086(+) ATATA-/T/TA  
            
    ATTTT
    1 -- int11NA 2
    rs75945641,2
    C,F--103234177(+) GCTGAG/AAATAT 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs126144271,2
    H--103234329(+) CATTTC/TTACAC 1 -- us2k10--------
    rs1145421041,2
    C,F--103234450(+) AGATAC/TTCAAA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs67185791,2
    C--103234510(+) ACATAC/TCTTTA 1 -- us2k10--------
    rs1380837431,2
    --103234534(+) GTGAAA/GGGAGA 1 -- us2k10--------
    rs1425721001,2
    --103234566(+) GCCCAA/GTGATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC9A2 (103236166 - 103327809 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SLC9A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2584069CNV Deletion19546169
    esv2417258CNV Deletion18987734
    esv2720463CNV Deletion23290073
    esv1033494CNV Insertion17803354
    esv8909CNV Loss19470904
    nsv214011CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC9A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC9A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600530    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SLC9A2:
    Leptospirosis

    Find genes that share disorders with SLC9A2           About GenesLikeMe

    1 Novoseek inferred disease relationship for SLC9A2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenoma 1.67 1 18845559 (1)

    Genetic Association Database (GAD): SLC9A2
    Human Genome Epidemiology (HuGE) Navigator: SLC9A2 (3 documents)

    Export disorders for SLC9A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC9A2 gene, integrated from 10 sources (see all 85):
    (articles sorted by number of sources associating them with SLC9A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2. (PubMed id 10444453)1, 2, 9 Malakooti J....Ramaswamy K. (Am. J. Physiol. 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Extensive genetic analysis of 10 candidate genes for hypertension in Japanese. (PubMed id 16982955)1, 4 Iwai N....Tomoike H. (Hypertension 2006)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA. (PubMed id 8843774)1, 9 Dudeja P.K....Ramaswamy K. (Am. J. Physiol. 1996)
    6. Human duodenal mucosal brush border Na(+)/H(+) exchangers NHE2 and NHE3 alter net bicarbonate movement. (PubMed id 11408268)1, 9 Repishti M....Isenberg J.I. (Am. J. Physiol. Gastrointest. Liver Physiol. 2001)
    7. NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells. (PubMed id 17943310)1, 9 BeltrA!n A.R....Malnic G. (Pflugers Arch. 2008)
    8. Morphological adaptation with preserved proliferation/transporter content in the colon of patients with short bowel syndrome. (PubMed id 19389806)1, 9 Joly F....Thomas M. (Am. J. Physiol. Gastrointest. Liver Physiol. 2009)
    9. The human Na(+)/H(+) exchanger NHE2 gene: genomic organization and promoter characterization. (PubMed id 11254504)1, 9 Malakooti J....Ramaswamy K. (Am. J. Physiol. Gastrointest. Liver Physiol. 2001)
    10. Molecular cloning, sequencing, chromosomal localization, and tissue distribution of the human Na+/H+ exchanger (SLC9A2). (PubMed id 8595899)1, 9 Ghishan F.K....Summar M. (Genomics 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6549 HGNC: 11072 AceView: SLC9A2 Ensembl:ENSG00000115616 euGenes: HUgn6549
    ECgene: SLC9A2 H-InvDB: SLC9A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC9A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC9A2 gene:
    Search GeneIP for patents involving SLC9A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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