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Aliases for SLC9A1 Gene

Aliases for SLC9A1 Gene

  • Solute Carrier Family 9, Subfamily A (NHE1, Cation Proton Antiporter 1), Member 1 2 3
  • APNH 3 4 6
  • NHE1 3 4 6
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 1 (Antiporter, Na+/H+, Amiloride Sensitive) 2 3
  • Na(+)/H(+) Exchanger 1 3 4
  • NHE-1 3 4
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 1 (Antiporter, Na+/H+, Amiloride Sensitive) 3
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 1 2
  • Protein Phosphatase 1, Regulatory Subunit 143 3
  • Na(+)/H(+) Antiporter, Amiloride-Sensitive 4
  • Solute Carrier Family 9 Member 1 4
  • Sodium/Hydrogen Exchanger 1 3
  • Na-Li Countertransporter 3
  • Regulatory Subunit 143 2
  • Protein Phosphatase 1 2
  • PPP1R143 3
  • LIKNS 3
  • APNH1 4

External Ids for SLC9A1 Gene

Previous Symbols for SLC9A1 Gene

  • APNH
  • NHE1

Summaries for SLC9A1 Gene

Entrez Gene Summary for SLC9A1 Gene

  • This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. [provided by RefSeq, Sep 2011]

GeneCards Summary for SLC9A1 Gene

SLC9A1 (Solute Carrier Family 9, Subfamily A (NHE1, Cation Proton Antiporter 1), Member 1) is a Protein Coding gene. Diseases associated with SLC9A1 include myocardial stunning and myocardial infarction. Among its related pathways are Proteoglycans in cancer and Regulation of actin cytoskeleton. GO annotations related to this gene include calmodulin binding and sodium:proton antiporter activity. An important paralog of this gene is SLC9A4.

UniProtKB/Swiss-Prot for SLC9A1 Gene

  • Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.

Gene Wiki entry for SLC9A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC9A1 Gene

Genomics for SLC9A1 Gene

Genomic Location for SLC9A1 Gene

27,098,809 bp from pter
27,166,981 bp from pter
68,173 bases
Minus strand

Genomic View for SLC9A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC9A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC9A1 Gene

Proteins for SLC9A1 Gene

  • Protein details for SLC9A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/hydrogen exchanger 1
    Protein Accession:
    Secondary Accessions:
    • B1ALD6
    • D3DPL4
    • Q96EM2

    Protein attributes for SLC9A1 Gene

    815 amino acids
    Molecular mass:
    90763 Da
    Quaternary structure:
    • Oligomer (By similarity). Interacts with calmodulin and TESC. Interacts (via the juxtamembrane region of the cytoplasmic C-terminal domain) with CHP1; the interaction occurs at the plasma membrane in a calcium-dependent manner. Interacts with CHP2; the interaction occurs in a calcium-dependent manner.
    • Inhibited by amiloride and 5-amino-substituted derivatives and activated in a cooperative fashion by intracellular H(+). In quiescent cells upon growth factor stimulation, the apparent affinity for internal H(+) is increased, resulting in a persistent rise in cytoplasmic pH

    Three dimensional structures from OCA and Proteopedia for SLC9A1 Gene

    Alternative splice isoforms for SLC9A1 Gene


neXtProt entry for SLC9A1 Gene

Proteomics data for SLC9A1 Gene at MOPED

Post-translational modifications for SLC9A1 Gene

Other Protein References for SLC9A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC9A1 Gene

Domains for SLC9A1 Gene

Gene Families for SLC9A1 Gene


  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.:
    • P19634
genes like me logo Genes that share domains with SLC9A1: view

Function for SLC9A1 Gene

Molecular function for SLC9A1 Gene

GENATLAS Biochemistry: solute carrier protein family 9 (sodium/hydrogen exchange),member 1,involved in intracellular pH regulation and cell volume,isoform 1,basolateral membrane location in polarized cells (amiloride sensitive),ubiquitous,homolog to mouse Npe1,mutated in slow-wawe epilepsy
UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Fully active at acidic pHs, the antiporter is virtually turned off at neutral pH.;
UniProtKB/Swiss-Prot Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.

Gene Ontology (GO) - Molecular Function for SLC9A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11350981
GO:0005516 calmodulin binding IEA --
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding TAS 17565280
GO:0015299 solute:proton antiporter activity TAS 2536298
GO:0015385 sodium:proton antiporter activity ISS --
genes like me logo Genes that share ontologies with SLC9A1: view
genes like me logo Genes that share phenotypes with SLC9A1: view

Animal Models for SLC9A1 Gene

MGI Knock Outs for SLC9A1:

miRNA for SLC9A1 Gene

miRTarBase miRNAs that target SLC9A1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC9A1 Gene

Localization for SLC9A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC9A1 Gene

Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with CHP1 at the reticulum endoplasmic (By similarity). Colocalizes with CHP1 and CHP2 at the plasma membrane. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SLC9A1 Gene COMPARTMENTS Subcellular localization image for SLC9A1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
mitochondrion 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC9A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 21553168
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum ISS --
genes like me logo Genes that share ontologies with SLC9A1: view

Pathways for SLC9A1 Gene

genes like me logo Genes that share pathways with SLC9A1: view

Gene Ontology (GO) - Biological Process for SLC9A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002026 regulation of the force of heart contraction --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006811 ion transport TAS --
GO:0006812 cation transport --
GO:0006814 sodium ion transport --
genes like me logo Genes that share ontologies with SLC9A1: view

Compounds for SLC9A1 Gene

(5) Tocris Compounds for SLC9A1 Gene

Compound Action Cas Number
AR-C155858 MCT1 and MCT2 inhibitor [496791-37-8]
N2-Methyl-L-arginine Lysosomal system c L-arginine uptake inhibitor [2480-28-6]
Phlorizin Na+-glucose cotransporter inhibitor [60-81-1]
UK 5099 Inhibitor of pyruvate transport [56396-35-1]
VU 0240551 KCC2 inhibitor [893990-34-6]

(1) HMDB Compounds for SLC9A1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Sodium

(2) Drugbank Compounds for SLC9A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • Amilorida [INN-Spanish]
2016-88-8 target inhibitor
Homoserine Lactone
1192-20-7 target

(59) Novoseek inferred chemical compound relationships for SLC9A1 Gene

Compound -log(P) Hits PubMed IDs
cariporide 93.2 36
hoe 694 92.4 9
eipa 89.5 22
hoe-642 84 9
bcecf 81.7 3
genes like me logo Genes that share compounds with SLC9A1: view

Transcripts for SLC9A1 Gene

Unigene Clusters for SLC9A1 Gene

Solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC9A1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - - - - -
SP2: -
SP4: - - -
SP5: - - - - - -
SP7: -
SP8: - - - - - -

ExUns: 16b ^ 17a · 17b

Relevant External Links for SLC9A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC9A1 Gene

mRNA expression in normal human tissues for SLC9A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC9A1 Gene

SOURCE GeneReport for Unigene cluster for SLC9A1 Gene Hs.91389

mRNA Expression by UniProt/SwissProt for SLC9A1 Gene

Tissue specificity: Kidney and intestine
genes like me logo Genes that share expressions with SLC9A1: view

Orthologs for SLC9A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC9A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC9A1 36
  • 94.62 (n)
  • 93.83 (a)
(Bos Taurus)
Mammalia SLC9A1 36
  • 91.7 (n)
  • 94.72 (a)
SLC9A1 37
  • 94 (a)
(Canis familiaris)
Mammalia NHE1 37
  • 96 (a)
SLC9A1 36
  • 92.07 (n)
  • 95.83 (a)
(Mus musculus)
Mammalia Slc9a1 36
  • 89.67 (n)
  • 93.85 (a)
Slc9a1 16
Slc9a1 37
  • 93 (a)
(Monodelphis domestica)
Mammalia SLC9A1 37
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia SLC9A1 37
  • 84 (a)
(Rattus norvegicus)
Mammalia Slc9a1 36
  • 90.14 (n)
  • 93.87 (a)
(Gallus gallus)
Aves NHE1 37
  • 86 (a)
SLC9A1 36
  • 80.83 (n)
  • 83.92 (a)
(Anolis carolinensis)
Reptilia SLC9A1 37
  • 72 (a)
African clawed frog
(Xenopus laevis)
Amphibia NHE 36
tropical clawed frog
(Silurana tropicalis)
Amphibia slc9a1 36
  • 74.88 (n)
  • 84.87 (a)
Str.7259 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11910 36
(Danio rerio)
Actinopterygii slc9a1 36
  • 71.21 (n)
  • 68.7 (a)
SLC9A1 37
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nhe2 37
  • 24 (a)
(Caenorhabditis elegans)
Secernentea nhx-1 37
  • 40 (a)
nhx-2 37
  • 35 (a)
nhx-3 37
  • 36 (a)
nhx-6 37
  • 35 (a)
nhx-9 37
  • 36 (a)
nhx-9 38
  • 40 (a)
nhx-7 38
  • 34 (a)
nhx-6 38
  • 39 (a)
nhx-3 38
  • 39 (a)
nhx-2 38
  • 41 (a)
Species with no ortholog for SLC9A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC9A1 Gene

Gene Tree for SLC9A1 (if available)
Gene Tree for SLC9A1 (if available)

Paralogs for SLC9A1 Gene

Paralogs for SLC9A1 Gene

Selected SIMAP similar genes for SLC9A1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC9A1: view

Variants for SLC9A1 Gene

Sequence variations from dbSNP and Humsavar for SLC9A1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs5810 -- 27,099,728(-) CTGAG(C/T)GTCTC utr-variant-3-prime, nc-transcript-variant
rs752453 -- 27,129,088(-) CTCTT(G/T)CCTCC intron-variant
rs752454 -- 27,129,014(-) CGGGA(A/G)TGTCT intron-variant
rs1058269 -- 27,099,766(-) AACCT(A/G)TCCTT utr-variant-3-prime, nc-transcript-variant
rs1058311 -- 27,098,894(-) AAGCC(A/C)CCGCA utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC9A1 Gene

Variant ID Type Subtype PubMed ID
nsv834535 CNV Gain+Loss 17160897
nsv509058 CNV Insertion 20534489
esv28309 CNV Loss 19812545
esv2659298 CNV Deletion 23128226

Relevant External Links for SLC9A1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for SLC9A1 Gene

(37) Novoseek inferred disease relationships for SLC9A1 Gene

Disease -log(P) Hits PubMed IDs
acidosis 69.3 12
hypertrophy 42.6 19
cardiac hypertrophy 35.4 5
essential hypertension 32.7 7
diabetic nephropathies 31.1 3

Relevant External Links for SLC9A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC9A1: view

No data available for UniProtKB/Swiss-Prot for SLC9A1 Gene

Publications for SLC9A1 Gene

  1. Cloning and analysis of the human myocardial Na+/H+ exchanger. (PMID: 8283968) Fliegel L. … Haworth R.S. (Mol. Cell. Biochem. 1993) 2 3 4 23
  2. Silent polymorphisms within the coding region of human sodium/hydrogen exchanger isoform-1 cDNA in peripheral blood mononuclear cells of leukemia patients: a comparison with healthy controls. (PMID: 10913675) Garden O.A. … Rich I.N. (Cancer Genet. Cytogenet. 2000) 3 4 23
  3. A novel topology model of the human Na(+)/H(+) exchanger isoform 1. (PMID: 10713111) Wakabayashi S. … Shigekawa M. (J. Biol. Chem. 2000) 3 4 23
  4. Proline residues in transmembrane segment IV are critical for activity, expression and targeting of the Na+/H+ exchanger isoform 1. (PMID: 14680478) Slepkov E.R. … Fliegel L. (Biochem. J. 2004) 3 4 23
  5. Structural and functional characterization of transmembrane segment IV of the NHE1 isoform of the Na+/H+ exchanger. (PMID: 15677483) Slepkov E.R. … Fliegel L. (J. Biol. Chem. 2005) 3 4 23

Products for SLC9A1 Gene

Sources for SLC9A1 Gene

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