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SLC9A1 Gene

protein-coding GIFtS: 68

GC01M027297

solute carrier family 9 (sodium/hydrogen exchanger), member 1
(Previous names: solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: APNH, NHE1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
APNH ^², ³, ⁵
APNH1 ^³
FLJ42224 ^²
NHE-1 ^³
NHE1 ^², ³, ⁵
OTTHUMP00000004468 ^²

Descriptions
Na(+)/H(+) antiporter, amiloride-sensitive ^³
Na(+)/H(+) exchanger 1 ^³
Na+/H+ antiporter, amiloride-sensitive ^²
Na-Li countertransporter ^²
Solute carrier family 9 member 1 ^³
sodium/hydrogen exchanger 1 ^²
solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive) ^¹, ²
solute carrier family 9 (sodium/hydrogen exchanger), member 1 ^²
solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive) ^²
solute carrier family 9, isoform A1 ^²

External Ids
HGNC: 11071¹
Entrez Gene: 6548²
UniProtKB: P19634³
Ensembl: ENSG00000090020⁷

Search outside databases for aliases for SLC9A1 gene

Previous GC identifers: GC01P028110 GC01M026457 GC01M026658 GC01M027029 GC01M027109

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SLC9A1:

The Na+/H+ antiporter (SLC9A1) is a ubiquitous membrane-bound enzyme involved in pH regulation of

vertebrate cells. It is specifically inhibited by the diuretic drug amiloride and activated by a

variety of signals including growth factors, mitogens, neurotransmitters, tumor promoters, and

others (Mattei et al., 1988 [PubMed 2846238]).[supplied by OMIM]

UniProtKB/Swiss-Prot: SL9A1_HUMAN, P19634

Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter

adverse environmental conditions. Major proton extruding system driven by the inward sodium ion

chemical gradient. Plays an important role in signal transduction

Gene Wiki entry for SLC9A1 (Sodium-hydrogen_antiporter_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SLC9A1 gene

Entrez Gene cytogenetic band: 1p36.1-p35 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p36.1-p35

SLC9A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M027297: (about GC identifiers)

Start:	27,297,893 bp from pter
End:	27,366,059 bp from pter
Size:	68,167 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004610.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SL9A1_HUMAN, P19634 (See protein sequence)

Recommended Name: Sodium/hydrogen exchanger 1

Size: 815 amino acids; 90763 Da

Subunit: Interacts with tescalcin, CHP and CHP2

Subcellular location: Membrane; Multi-pass membrane protein

Miscellaneous: Inhibited by amiloride and 5-amino-substituted derivatives and activated in a

cooperative fashion by intracellular H(+). In quiescent cells upon growth factor stimulation, the

apparent affinity for internal H(+) is increased, resulting in a persistent rise in cytoplasmic pH

Caution: The region between transmembrane regions M4 and M5 and between M6 and M7 (also termed

intracellular loops IL2 and IL4, respectively) seem to be localized at least in part in the

membrane. The hydrophobic region H10 is proposed to be located within the membrane

PDB structures from and Proteopedia :

1Y4E (3D)

2BEC (3D)

2E30 (3D)

2KBV (3D)

Secondary accessions: Q96EM2

Alternative splicing: 2 isoforms: P19634-1 P19634-2

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

O-glycosylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003038.2

ENSEMBL proteins:

ENSP00000363197 ENSP00000363199 ENSP00000363202 ENSP00000263980

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant SLC9A1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Sodium / Hydrogen Exchanger 1)
	Human Recombinant Proteins from Abnova (SLC9A1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	TAS	8283968
GO:0016323	basolateral plasma membrane	IEA	--
GO:0045121	membrane raft	IEA	--

About this table

Antibodies for SLC9A1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of SLC9A1
	Sigma-Aldrich Antibodies for SLC9A1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Sodium / Hydrogen Exchanger 1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SLC9A1)
	Novus Biologicals Antibody for SLC9A1

Assays for SLC9A1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P19634

ProtoNet protein and cluster: P19634

3 Blocks protein families:

IPB001970 Na+/H+ exchanger isoform 1 (NHE1) signature

IPB004709 Na+/H+ exchanger signature

IPB006153 Sodium/hydrogen exchanger

UniProtKB/Swiss-Prot: SL9A1_HUMAN, P19634

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36)

family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SLC9A1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SLC9A1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003047

Applied Biosystems Silencer® siRNAs for SLC9A1

Sigma-Aldrich siRNA and siRNA Panels for SLC9A1

Sigma-Aldrich shRNA for SLC9A1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003047
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003047
untagged cDNA clone in CMV expression vector: NM_003047

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003047

UniProtKB/Swiss-Prot: SL9A1_HUMAN, P19634

Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter

adverse environmental conditions. Major proton extruding system driven by the inward sodium ion

chemical gradient. Plays an important role in signal transduction

Biophysicochemical properties: pH dependence: Fully active at acidic pHs, the antiporter is

virtually turned off at neutral pH;

Genatlas biochemistry entry for SLC9A1:

solute carrier protein family 9 (sodium/hydrogen exchange),member 1,involved in intracellular pH

regulation and cell volume,isoform 1,basolateral membrane location in polarized cells (amiloride

sensitive),ubiquitous,homolog to mouse Npe1,mutated in slow-wawe epilepsy

11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Slc9a1):

	behavior/neurological	digestive/alimentary	endocrine/exocrine gland	growth/size
homeostasis/metabolism	lethality-postnatal	life span-post-weaning/aging	nervous system	reproductive system
skin/coat/nails

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008134	transcription factor binding	IEA	--
GO:0015297	antiporter activity	IEA	--
GO:0015299	solute:hydrogen antiporter activity	TAS	2536298
GO:0015385	sodium:hydrogen antiporter activity	IEA	--
GO:0031402	sodium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for SLC9A1 (Your Favorite Gene powered by Ingenuity)

Aldosterone Signaling in Epithelial Cells
Actin Cytoskeleton Signaling

GeneDecks SLC9A1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for SLC9A1

5/40 Interacting proteins for SLC9A1 (ENSP00000263980³ P19634²) via UniProtKB, MINT, and/or STRING (see all 40 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CHP2	O43745²	STRING (score=.999) MINT-2729935
MDFI	Q99750²	MINT-66368
CA2	ENSP00000285379³	STRING (score=.992)
EZR	ENSP00000356041³	STRING (score=.992)
RDX	ENSP00000342830³	STRING (score=.991)

About this table

5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006812	cation transport	IEA	--
GO:0006814	sodium ion transport	IEA	--
GO:0006885	regulation of pH	TAS	8283968
GO:0007243	protein kinase cascade	IEA	--
GO:0014070	response to organic cyclic substance	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for SLC9A1:

Antagonist Inhibitor

Compounds for SLC9A1 available from Tocris Bioscience

Compound	Action	CAS number
Zoniporide dihydrochloride	Selective NHE-1 inhibitor	[241800-97-5]

About this table

10/35 Novoseek chemical compound relationships for SLC9A1 gene (see all 35 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hoe 694	92.00	8	14690446 (3), 15966699 (1), 7603840 (1), 10481210 (1) (see all 6)
bcecf	81.55	5	17982257 (1), 7726835 (1), 8201013 (1)
dimethyl amiloride	70.20	5	9425602 (1), 16800927 (1)
chp1	67.02	19	15035633 (6), 17050540 (5)
sodium	57.96	35	14561010 (3), 10028059 (2), 15232215 (1), 15808834 (1) (see all 23)
bicarbonate	48.94	6	11682397 (2), 16475831 (1), 12782397 (1), 17347411 (1)
hydrogen	45.12	20	17916606 (2), 18661333 (2), 11181403 (1), 7603840 (1) (see all 17)
ionomycin	32.14	9	8175807 (3), 9054465 (2), 7592862 (1)
calcium	29.17	48	8647925 (4), 8806985 (4), 8175807 (3), 9054465 (2) (see all 19)
okadaic acid	29.04	5	1655777 (3), 15823043 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SLC9A1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SLC9A1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003047

Sigma-Aldrich siRNA and siRNA Panels for SLC9A1

Sigma-Aldrich shRNA for SLC9A1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003047

REFSEQ mRNAs for SLC9A1 gene:

NM_003047.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003047

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003047
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003047
                                 untagged cDNA clone in CMV expression vector: NM_003047

Additional cDNA sequence:

AF141350.1 AF141351.1 AF141352.1 AF141353.1 AF141354.1 AF141355.1 AF141356.1 AF141357.1

AF141358.1 AF141359.1 AF146430.1 AF146431.1 AF146432.1 AF146433.1 AF146434.1 AF146435.1

AF146436.1 AF146437.1 AF146438.1 AF146439.1 AK124218.1 AK300432.1 AK314190.1 BC012121.1

M81768.1 M96066.1 M96067.1 S68616.1

9 DOTS entries:

DT.415273 DT.91833324 DT.101975789 DT.95310461 DT.86855354 DT.95335259 DT.97843152 DT.100749509

DT.91911205

24/196 AceView cDNA sequences (see all 196 ):

AF146432 BE613873 AI283384 BM976520 AI359056 AF146435 AF141358 AF146437

AF146439 AA610190 BF445308 BI753195 BM562585 BU734387 BE701543 BM710558

BQ003220 BQ676326 CA446690 AF146438 BU631070 AU141670 BU729433 AI347429

highest scoring ESTs for SLC9A1:

S68616 AF141350 AF141351 AF141352 AF141353 AF141354 AF141355 AF141356 AF141357 AF141358

Unigene Cluster for SLC9A1:

Solute carrier family 9 (sodium/hydrogen exchanger), member 1

Hs.469116 [show with all ESTs]

Unigene Representative Sequence: NM_003047

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SLC9A1 (see all 9 )

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	^	7	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15	^	16a	·
SP1:											-		-		-																-		-				-
SP2:																																					-
SP3:
SP4:											-		-		-
SP5:			-		-		-				-		-		-

ExUns:	16b	^	17a	·	17b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for SLC9A1

4 Ensembl transcripts including schematic representations:

ENST00000374084 ENST00000374086 ENST00000374089 ENST00000263980

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SLC9A1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SLC9A1

¹ / ² / ³

4 probe-sets matching SLC9A1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32681_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	S68616	1.00	1.00	1.00	1
209453_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M81768	0.80	1.00	0.91	1
209453_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554728_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAAGGGTGAC

SOURCE GeneReport for Unigene cluster: Hs.469116
Expression variation in blood from EXPOLDB for SLC9A1
UniProtKB/Swiss-Prot: SL9A1_HUMAN, P19634
Tissue specificity: Kidney and intestine

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SLC9A1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SLC9A1¹	--	solute carrier family 9 (sodium/hydrogen exchanger), more	92.11(n) 95.83(a)	478171 XM_535345.2 XP_535345.2
chimpanzee (Pan troglodytes)	SLC9A1¹	--	solute carrier family 9 (sodium/hydrogen exchanger), more	92.21(n) 89.8(a)	456669 XM_513239.2 XP_513239.2
cow (Bos taurus)	SLC9A1¹	--	solute carrier family 9 (sodium/hydrogen exchanger), more	91.74(n) 94.72(a)	317654 NM_174833.2 NP_777258.1
rat (Rattus norvegicus)	Slc9a1¹	--	solute carrier family 9 (sodium/hydrogen exchanger), more	90.18(n) 93.87(a)	24782 NM_012652.1 NP_036784.1
mouse (Mus musculus)	Slc9a1^{1, 5}	4 (64.60 cM)⁵	solute carrier family 9 (sodium/hydrogen exchanger), more^{1, 5}	89.83(n)¹ 93.85(a)¹	20544¹ NM_016981.2¹ NP_058677.1¹ AK150135⁵ AK154857⁵ (see all 15)

About this table Species with no ortholog for SLC9A1

ENSEMBL Gene Tree for SLC9A1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SLC9A1 gene

SLC9A2² SLC9A4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/220 NCBI SNPs in SLC9A1 are shown (see all 220 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 61)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs5810^1,2	C,F,H	27298806(-)	`CTGAGT/CGTCTC`	1	--	ut3¹ ese³		12		MN EA EU WA NA	2630
	rs4266911^1,2	C,F,H	27299383(-)	`GTAACG/ACCAGG`	1	--	ut3¹ ese³		4		EU EA WA	412
	rs11588974^1,2	A,C	27354359(+)	`ATGACA/CAAAAA`	1	--	ng3¹ trp³		0	--	--	--	--
	rs3738690^1,2	H	27308807(+)	`CACGAT/CGCCCA`	1	V/I	mis¹ ese³		4		EU EA WA	418
	rs7556004^1,2	H	27298297(+)	`GGGAAA/CGGTTC`	1	--	ut3¹ trp³		4		EU EA WA	420
	rs35703140^1,2	F	27300345(-)	`AACAAC/ATACCT`	1	K/N	mis¹		1		NA	68
	rs11579458^1,2	C	27354202(+)	`GCAGAC/TTGAAG`	1	--	ng3¹		0	--	--	--	--
	rs3765514^1,2	H	27298969(+)	`GCCTAC/TTCAAG`	1	--	ut3¹ ese³		2		EA EU	1576
--	rs7542969^1,2	C	27354117(+)	`GCGCGA/GCGCGG`	1	--	ng3¹		0	--	--	--	--
	rs4418629^1,2	C,F,H	27299628(-)	`AATGAG/AGAGCT`	1	E/E	syn¹		8		EU EA WA NA	634

About this table

HapMap Linkage Disequilibrium images for SLC9A1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 107310

10/37 Novoseek disease relationships for SLC9A1 gene (see all 37 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
acidosis	68.80	13	17209041 (2), 17982257 (1), 8389452 (1), 7961730 (1) (see all 11)
hypertrophy	43.99	23	15808834 (3), 15674430 (2), 17429605 (2), 18329039 (2) (see all 14)
cardiac hypertrophy	36.91	5	19063706 (2), 17429605 (1), 18776042 (1), 18508719 (1)
essential hypertension	33.64	8	7875760 (2), 8806985 (2), 9683037 (2), 9008252 (1)
diabetic nephropathies	32.62	4	7783665 (1), 10860861 (1), 7698504 (1)
ischemia	30.79	18	18511042 (4), 12650871 (3), 17664275 (2), 16586098 (1) (see all 11)
heart failure	30.29	25	12223070 (3), 11518188 (3), 18329039 (3), 11964375 (3) (see all 10)
infarct	28.37	10	11704395 (2), 12223070 (1), 10836732 (1), 18329039 (1) (see all 8)
myocardial stunning	23.01	1	12831348 (1)
myocardial fibrosis	19.62	1	14504689 (1)

About this table

Genetic Association Database: SLC9A1
Human Genome Epidemiology Navigator: SLC9A1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/312 PubMed articles for SLC9A1 gene (see all 312 ):

Cloning and analysis of the human myocardial Na+/H+ exchanger. (PubMed id 8283968)^{2, 3, 4} Fliegel L.... Haworth R.S. (1993)
Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1. (PubMed id 17050540)^{1, 3, 4} Mishima M....Kojima C. (2007)
Silent polymorphisms within the coding region of human sodium/hydrogen exchanger isoform-1 cDNA in peripheral blood mononuclear cells of leukemia patients: a comparison with healthy controls. (PubMed id 10913675)^{1, 3, 4} Garden O.A.... Rich I.N. (2000)
Proline residues in transmembrane segment IV are critical for activity, expression and targeting of the Na+/H+ exchanger isoform 1. (PubMed id 14680478)^{1, 3, 4} Slepkov E.R.... Fliegel L. (2004)
Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation. (PubMed id 16710297)^{3, 4} Ammar Y.B....Wakabayashi S. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
Structural and functional characterization of transmembrane segment IV of the NHE1 isoform of the Na+/H+ exchanger. (PubMed id 15677483)^{3, 4} Slepkov E.R.... Fliegel L. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger. (PubMed id 12226101)^{3, 4} Pang T.... Shigekawa M. (2002)
[Relationship between alpha-ENaC gene Thr663Ala polymorphism and ischemic stroke] (PubMed id 12905871)^{3, 6} Zhao Y....Lindpaintner K. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 6548	HGNC: 11071	AceView: SLC9A1	Ensembl:ENSG00000090020	euGenes: HUgn6548
ECgene: SLC9A1	H-InvDB: SLC9A1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for SLC9A1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SLC9A1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SLC9A1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SLC9A1		Antibodies for SLC9A1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SLC9A1		Small molecules for SLC9A1
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SLC9A1)
	Antibodies (SLC9A1)
	Chimera RNAi (SLC9A1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Sodium / Hydrogen Exchanger 1)
	Antibodies (Sodium / Hydrogen Exchanger 1)

Search OriGene for SLC9A1

Tocris compounds for SLC9A1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for SLC9A1

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SLC9A1 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for SLC9A1

Summaries
for SLC9A1

Genomic Location
for SLC9A1

Proteins
for SLC9A1

Protein Domains/
Families
for SLC9A1

Gene Function
for SLC9A1

Pathways & Interactions
for SLC9A1

Drugs & Compounds
for SLC9A1

Transcripts
for SLC9A1

Expression
for SLC9A1

Orthologs
for SLC9A1

Paralogs
for SLC9A1

SNPs/Variants
for SLC9A1

Disorders & Mutations
for SLC9A1

Medical News
for SLC9A1

Publications
for SLC9A1

Search for SLC9A1

Genome Databases showing SLC9A1

Other Databases showing SLC9A1

Specialized Databases showing SLC9A1

Licensable Technologies
for SLC9A1

Services
for SLC9A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SLC9A1 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor SLC9A1

Summariesfor SLC9A1

Genomic Locationfor SLC9A1

Proteinsfor SLC9A1

Protein Domains/Familiesfor SLC9A1

Gene Functionfor SLC9A1

Pathways & Interactionsfor SLC9A1

Drugs & Compoundsfor SLC9A1

Transcriptsfor SLC9A1

Expression for SLC9A1

Orthologsfor SLC9A1

Paralogsfor SLC9A1

SNPs/Variantsfor SLC9A1

Disorders & Mutationsfor SLC9A1

Medical Newsfor SLC9A1

Publicationsfor SLC9A1

Search for SLC9A1

Genome Databases showing SLC9A1

Other Databases showing SLC9A1

Specialized Databases showing SLC9A1

Licensable Technologiesfor SLC9A1

Servicesfor SLC9A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SLC9A1

Summaries
for SLC9A1

Genomic Location
for SLC9A1

Proteins
for SLC9A1

Protein Domains/
Families
for SLC9A1

Gene Function
for SLC9A1

Pathways & Interactions
for SLC9A1

Drugs & Compounds
for SLC9A1

Transcripts
for SLC9A1

Expression
for SLC9A1

Orthologs
for SLC9A1

Paralogs
for SLC9A1

SNPs/Variants
for SLC9A1

Disorders & Mutations
for SLC9A1

Medical News
for SLC9A1

Publications
for SLC9A1

Licensable Technologies
for SLC9A1

Services
for SLC9A1