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Aliases for SLC8B1 Gene

Aliases for SLC8B1 Gene

  • Solute Carrier Family 8 (Sodium/Lithium/Calcium Exchanger), Member B1 2 3
  • SLC24A6 3 4 6
  • NCKX6 3 4 6
  • Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger), Member 6 2 3
  • Solute Carrier Family 24 (Sodium/Lithium/Calcium Exchanger), Member 6 2 3
  • Sodium/Calcium Exchanger Protein, Mitochondrial 3 4
  • Na(+)/K(+)/Ca(2+)-Exchange Protein 6 3 4
  • Solute Carrier Family 24 Member 6 3 4
  • Solute Carrier Family 8 Member B1 3 4
  • NCLX 3 4
  • Sodium/Potassium/Calcium Exchanger 6, Mitochondrial 3

External Ids for SLC8B1 Gene

Previous HGNC Symbols for SLC8B1 Gene

  • SLC24A6

Previous GeneCards Identifiers for SLC8B1 Gene

  • GC12M113741

Summaries for SLC8B1 Gene

Entrez Gene Summary for SLC8B1 Gene

  • SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC8B1 Gene

SLC8B1 (Solute Carrier Family 8 (Sodium/Lithium/Calcium Exchanger), Member B1) is a Protein Coding gene. Among its related pathways are Visual Cycle in Retinal Rods and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include calcium:sodium antiporter activity. An important paralog of this gene is SLC24A4.

UniProtKB/Swiss-Prot for SLC8B1 Gene

  • Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, thereby acting as a key regulator of mitochondrion calcium homeostasis. Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC8B1 Gene

Genomics for SLC8B1 Gene

Genomic Location for SLC8B1 Gene

Start:
113,298,759 bp from pter
End:
113,359,493 bp from pter
Size:
60,735 bases
Orientation:
Minus strand

Genomic View for SLC8B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC8B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC8B1 Gene

No data available for Regulatory Elements for SLC8B1 Gene

Proteins for SLC8B1 Gene

  • Protein details for SLC8B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6J4K2-NCKX6_HUMAN
    Recommended name:
    Sodium/potassium/calcium exchanger 6, mitochondrial
    Protein Accession:
    Q6J4K2
    Secondary Accessions:
    • A6NP50
    • Q4KMS9
    • Q6J4K1
    • Q9H6I8

    Protein attributes for SLC8B1 Gene

    Size:
    584 amino acids
    Molecular mass:
    64231 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15271.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC8B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC8B1 Gene

Proteomics data for SLC8B1 Gene at MOPED

Post-translational modifications for SLC8B1 Gene

No data available for DME Specific Peptides for SLC8B1 Gene

Domains for SLC8B1 Gene

Gene Families for SLC8B1 Gene

HGNC:
  • SLC :Solute carriers

Protein Domains for SLC8B1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6J4K2

UniProtKB/Swiss-Prot:

NCKX6_HUMAN :
  • Q6J4K2
Family:
  • Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.
genes like me logo Genes that share domains with SLC8B1: view

No data available for Suggested Antigen Peptide Sequences for SLC8B1 Gene

Function for SLC8B1 Gene

Molecular function for SLC8B1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly inhibited by zinc
UniProtKB/Swiss-Prot Function:
Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, thereby acting as a key regulator of mitochondrion calcium homeostasis. Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+).

Gene Ontology (GO) - Molecular Function for SLC8B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005432 calcium:sodium antiporter activity IMP 20018762
GO:0042803 protein homodimerization activity IPI 20018762
GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential TAS 20018762
genes like me logo Genes that share ontologies with SLC8B1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC8B1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC8B1 Gene

Localization for SLC8B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC8B1 Gene

Mitochondrion inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Mainly localizes to mitochondrion inner membrane.

Gene Ontology (GO) - Cellular Components for SLC8B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane --
GO:0030061 mitochondrial crista IDA 20018762
genes like me logo Genes that share ontologies with SLC8B1: view

No data available for Subcellular locations from COMPARTMENTS for SLC8B1 Gene

Pathways for SLC8B1 Gene

genes like me logo Genes that share pathways with SLC8B1: view

Interacting Proteins for SLC8B1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000202831%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000267973%0d%0a9606.ENSP00000262715%0d%0a9606.ENSP00000448165%0d%0a9606.ENSP00000320246%0d%0a
Selected Interacting proteins: ENSP00000202831 Q6J4K2-NCKX6_HUMAN for SLC8B1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC8B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006851 mitochondrial calcium ion transport IMP 20018762
GO:0035725 sodium ion transmembrane transport IEA --
GO:0042593 glucose homeostasis IDA 23056385
GO:0050796 regulation of insulin secretion IDA 23056385
genes like me logo Genes that share ontologies with SLC8B1: view

Compounds for SLC8B1 Gene

(2) Novoseek inferred chemical compound relationships for SLC8B1 Gene

Compound -log(P) Hits PubMed IDs
potassium 27 2
calcium 25.3 1
genes like me logo Genes that share compounds with SLC8B1: view

Transcripts for SLC8B1 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC8B1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC8B1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - -
SP6: -
SP7: -
SP8: -
SP9: -
SP10:

ExUns: 18a · 18b · 18c · 18d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for SLC8B1 Gene

GeneLoc Exon Structure for
SLC8B1
ECgene alternative splicing isoforms for
SLC8B1

Expression for SLC8B1 Gene

mRNA expression in normal human tissues for SLC8B1 Gene

mRNA differential expression in normal tissues according to GTEx for SLC8B1 Gene

This gene is overexpressed in Adrenal Gland (4.7).

Protein differential expression in normal tissues for SLC8B1 Gene

This gene is overexpressed in Adrenal (38.3), Testis (20.4), and Placenta (10.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC8B1 Gene

mRNA Expression by UniProt/SwissProt for SLC8B1 Gene

Q6J4K2-NCKX6_HUMAN
Tissue specificity: Present in pancreatic beta-cells (at protein level).
genes like me logo Genes that share expressions with SLC8B1: view

Expression partners for SLC8B1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC8B1 Gene

Orthologs for SLC8B1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC8B1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC24A6 35
  • 86.42 (n)
  • 85.45 (a)
SLC8B1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC8B1 35
  • 85.62 (n)
  • 84.88 (a)
SLC8B1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc8b1 35
  • 81.13 (n)
  • 83.02 (a)
Slc24a6 16
Slc8b1 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC24A6 35
  • 98.92 (n)
  • 98.63 (a)
SLC24A6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc24a6 35
  • 80.79 (n)
  • 83.02 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC8B1 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves SLC24A6 35
  • 69.92 (n)
  • 68.06 (a)
SLC8B1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC8B1 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc8b1 35
  • 64.81 (n)
  • 69.54 (a)
Str.16130 35
zebrafish
(Danio rerio)
Actinopterygii LOC560601 35
  • 62.12 (n)
  • 61.36 (a)
FP103011.3 36
  • 48 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007338 35
  • 45.98 (n)
  • 34.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14744 35
  • 45.37 (n)
  • 31.65 (a)
CG12376 36
  • 20 (a)
OneToMany
CG13223 36
  • 24 (a)
OneToMany
CG14743 36
  • 18 (a)
OneToMany
CG14744 36
  • 23 (a)
OneToMany
CG5348 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ncx-7 35
  • 43.37 (n)
  • 37.55 (a)
ncx-10 36
  • 24 (a)
OneToMany
ncx-6 36
  • 29 (a)
OneToMany
ncx-7 36
  • 27 (a)
OneToMany
ncx-8 36
  • 23 (a)
OneToMany
ncx-9 36
  • 25 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CAX9 35
  • 44.47 (n)
  • 31.99 (a)
rice
(Oryza sativa)
Liliopsida Os03g0180000 35
  • 43.53 (n)
  • 31.9 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02826 35
  • 50.08 (n)
  • 38.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToOne
Species with no ortholog for SLC8B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC8B1 Gene

ENSEMBL:
Gene Tree for SLC8B1 (if available)
TreeFam:
Gene Tree for SLC8B1 (if available)

Paralogs for SLC8B1 Gene

Paralogs for SLC8B1 Gene

genes like me logo Genes that share paralogs with SLC8B1: view

Variants for SLC8B1 Gene

Sequence variations from dbSNP and Humsavar for SLC8B1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1129223 -- 113,310,337(-) GATAG(A/G)CGGCC missense, reference
rs1344670 -- 113,312,083(-) TTGAT(G/T)CCATC intron-variant
rs1975003 -- 113,321,228(-) TCCCT(C/T)CCAGC reference, missense, utr-variant-5-prime
rs2241543 -- 113,299,769(-) GAAGC(A/C)GCTTA utr-variant-3-prime
rs2288364 -- 113,318,901(-) CTTCA(C/G)TGCTG intron-variant

Relevant External Links for SLC8B1 Gene

HapMap Linkage Disequilibrium report
SLC8B1
Human Gene Mutation Database (HGMD)
SLC8B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC8B1 Gene

Disorders for SLC8B1 Gene

No disorders were found for SLC8B1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SLC8B1 Gene

Publications for SLC8B1 Gene

  1. Lithium-calcium exchange is mediated by a distinct potassium- independent sodium-calcium exchanger. (PMID: 15060069) Palty R. … Sekler I. (J. Biol. Chem. 2004) 3 4 23
  2. Molecular cloning of a sixth member of the K+-dependent Na+/Ca2+ exchanger gene family, NCKX6. (PMID: 14625281) Cai X. … Lytton J. (J. Biol. Chem. 2004) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. NCLX is an essential component of mitochondrial Na+/Ca2+ exchange. (PMID: 20018762) Palty R. … Sekler I. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4

Products for SLC8B1 Gene

Sources for SLC8B1 Gene

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