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Aliases for SLC8A3 Gene

Aliases for SLC8A3 Gene

  • Solute Carrier Family 8 Member A3 2 3
  • Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 3 2 3 5
  • Solute Carrier Family 8 Member 3 3 4
  • Na(+)/Ca(2+)-Exchange Protein 3 3 4
  • NCX3 3 4
  • Solute Carrier Family 8 (Sodium-Calcium Exchanger), Member 3 3
  • Sodium/Calcium Exchanger SLC8A3 3
  • Na+/Ca2+ Exchanger 3 3

External Ids for SLC8A3 Gene

Previous GeneCards Identifiers for SLC8A3 Gene

  • GC14M068017
  • GC14M064307
  • GC14M068500
  • GC14M069580
  • GC14M070510
  • GC14M050679

Summaries for SLC8A3 Gene

Entrez Gene Summary for SLC8A3 Gene

  • This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013]

GeneCards Summary for SLC8A3 Gene

SLC8A3 (Solute Carrier Family 8 Member A3) is a Protein Coding gene. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include calmodulin binding and calcium:cation antiporter activity. An important paralog of this gene is ADGRV1.

UniProtKB/Swiss-Prot for SLC8A3 Gene

  • Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity).

Tocris Summary for SLC8A3 Gene

  • The Na+/Ca2+ exchanger (NCX) is a low affinity, high capacitance calcium antiporter membrane protein that functions to regulate intracellular calcium concentrations. It is located on the plasma, mitochondrial and endoplasmic reticular membranes of excitable cells.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC8A3 Gene

Genomics for SLC8A3 Gene

Regulatory Elements for SLC8A3 Gene

Enhancers for SLC8A3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC8A3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC8A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC8A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC8A3 Gene

Chromosome:
14
Start:
70,044,217 bp from pter
End:
70,223,612 bp from pter
Size:
179,396 bases
Orientation:
Minus strand

Genomic View for SLC8A3 Gene

Genes around SLC8A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC8A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC8A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC8A3 Gene

Proteins for SLC8A3 Gene

  • Protein details for SLC8A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57103-NAC3_HUMAN
    Recommended name:
    Sodium/calcium exchanger 3
    Protein Accession:
    P57103
    Secondary Accessions:
    • Q5K3P6
    • Q5K3P7
    • Q8IUE9
    • Q8IUF0
    • Q8NFI7
    • Q96QG1
    • Q96QG2

    Protein attributes for SLC8A3 Gene

    Size:
    927 amino acids
    Molecular mass:
    103010 Da
    Quaternary structure:
    • Interacts with AKAP1.

    Alternative splice isoforms for SLC8A3 Gene

neXtProt entry for SLC8A3 Gene

Proteomics data for SLC8A3 Gene at MOPED

Post-translational modifications for SLC8A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC8A3 Gene

Domains & Families for SLC8A3 Gene

Gene Families for SLC8A3 Gene

Suggested Antigen Peptide Sequences for SLC8A3 Gene

Graphical View of Domain Structure for InterPro Entry

P57103

UniProtKB/Swiss-Prot:

NAC3_HUMAN :
  • The cytoplasmic Calx-beta domains bind the regulatory Ca(2+). The first Calx-beta domain can bind up to four Ca(2+) ions. The second domain can bind another two Ca(2+) ions that are essential for calcium-regulated ion exchange.
  • Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily.
Domain:
  • The cytoplasmic Calx-beta domains bind the regulatory Ca(2+). The first Calx-beta domain can bind up to four Ca(2+) ions. The second domain can bind another two Ca(2+) ions that are essential for calcium-regulated ion exchange.
  • Contains 2 Calx-beta domains.
Family:
  • Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily.
genes like me logo Genes that share domains with SLC8A3: view

Function for SLC8A3 Gene

Molecular function for SLC8A3 Gene

GENATLAS Biochemistry:
solute carrier family 8 (sodium-calcium exchange),member 3,expressed in brain and skeletal muscle
UniProtKB/Swiss-Prot EnzymeRegulation:
Calcium transport is down-regulated by Na(+) and stimulated by Ca(2+).
UniProtKB/Swiss-Prot Function:
Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity).
genes like me logo Genes that share phenotypes with SLC8A3: view

Animal Models for SLC8A3 Gene

MGI Knock Outs for SLC8A3:

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC8A3 Gene

Localization for SLC8A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC8A3 Gene

Cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection, dendrite. Cell projection, dendritic spine. Cell membrane, sarcolemma. Cytoplasm, sarcoplasm. Cell junction. Mitochondrion outer membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Detected at neuromuscular junctions. {ECO:0000250 UniProtKB:S4R2P9}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC8A3 Gene COMPARTMENTS Subcellular localization image for SLC8A3 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
plasma membrane 5
cytoskeleton 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC8A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane ISS --
GO:0005887 integral component of plasma membrane ISS --
GO:0016020 membrane IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with SLC8A3: view

Pathways & Interactions for SLC8A3 Gene

genes like me logo Genes that share pathways with SLC8A3: view

Gene Ontology (GO) - Biological Process for SLC8A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006851 mitochondrial calcium ion transport ISS --
GO:0006874 cellular calcium ion homeostasis ISS --
GO:0007154 cell communication IEA --
GO:0021537 telencephalon development IEA --
GO:0042552 myelination ISS --
genes like me logo Genes that share ontologies with SLC8A3: view

No data available for SIGNOR curated interactions for SLC8A3 Gene

Drugs & Compounds for SLC8A3 Gene

(3) Drugs for SLC8A3 Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
Benzamil Pharma Channel blocker NCX inhibitor, Deg/ENaC channel blocker; amiloride (Cat. No. 0890) derivative 0

(5) Additional Compounds for SLC8A3 Gene - From: Tocris, Novoseek, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
Bepridil hydrochloride
68099-86-5
CGP 37157
75450-34-9
KB-R7943 mesylate
182004-65-5
SN-6
415697-08-4

(5) Tocris Compounds for SLC8A3 Gene

Compound Action Cas Number
Benzamil NCX inhibitor, Deg/ENaC channel blocker; amiloride (Cat. No. 0890) derivative 161804-20-2
Bepridil hydrochloride Non-selective calcium channel blocker 68099-86-5
CGP 37157 Antagonist of mitochondrial Na+/Ca2+ exchange 75450-34-9
KB-R7943 mesylate Na+/Ca2+ exchange inhibitor (reverse mode) 182004-65-5
SN-6 Selective Na+/Ca2+ exchange inhibitor (reverse mode) 415697-08-4
genes like me logo Genes that share compounds with SLC8A3: view

Transcripts for SLC8A3 Gene

Unigene Clusters for SLC8A3 Gene

Solute carrier family 8 (sodium/calcium exchanger), member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC8A3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5:
SP6:

Relevant External Links for SLC8A3 Gene

GeneLoc Exon Structure for
SLC8A3
ECgene alternative splicing isoforms for
SLC8A3

Expression for SLC8A3 Gene

mRNA expression in normal human tissues for SLC8A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC8A3 Gene

This gene is overexpressed in Muscle - Skeletal (x12.9).

Protein differential expression in normal tissues from HIPED for SLC8A3 Gene

This gene is overexpressed in Frontal cortex (38.4), Retina (17.3), and Heart (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC8A3 Gene



SOURCE GeneReport for Unigene cluster for SLC8A3 Gene Hs.337696

mRNA Expression by UniProt/SwissProt for SLC8A3 Gene

P57103-NAC3_HUMAN
Tissue specificity: Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle.
genes like me logo Genes that share expression patterns with SLC8A3: view

Protein tissue co-expression partners for SLC8A3 Gene

- Elite partner

Primer Products

Orthologs for SLC8A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC8A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC8A3 35
  • 93.29 (n)
  • 97.19 (a)
SLC8A3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC8A3 35
  • 90.48 (n)
  • 93.29 (a)
SLC8A3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc8a3 35
  • 90.01 (n)
  • 95.13 (a)
Slc8a3 16
Slc8a3 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC8A3 35
  • 99.49 (n)
  • 100 (a)
SLC8A3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc8a3 35
  • 91.41 (n)
  • 97.51 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC8A3 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC8A3 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC8A3 35
  • 82.57 (n)
  • 92.05 (a)
NCX3 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC8A3 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc8a3 35
  • 76.76 (n)
  • 88.67 (a)
zebrafish
(Danio rerio)
Actinopterygii slc8a3 35
  • 72.57 (n)
  • 79.43 (a)
slc8a3 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Calx 37
  • 48 (a)
Calx 35
  • 56.88 (n)
  • 51.37 (a)
Calx 36
  • 45 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002859 35
  • 57.68 (n)
  • 54.41 (a)
worm
(Caenorhabditis elegans)
Secernentea Y113G7A.4 37
  • 46 (a)
ncx-2 35
  • 56.15 (n)
  • 51.1 (a)
ncx-1 36
  • 48 (a)
ManyToMany
ncx-2 36
  • 46 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2312 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
CSA.8047 36
  • 51 (a)
ManyToMany
Species with no ortholog for SLC8A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC8A3 Gene

ENSEMBL:
Gene Tree for SLC8A3 (if available)
TreeFam:
Gene Tree for SLC8A3 (if available)

Paralogs for SLC8A3 Gene

Paralogs for SLC8A3 Gene

(4) SIMAP similar genes for SLC8A3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC8A3: view

Variants for SLC8A3 Gene

Sequence variations from dbSNP and Humsavar for SLC8A3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_036463 A breast cancer sample
rs149250 -- 70,062,738(-) GCTTT(C/G)TCTTT intron-variant
rs149251 -- 70,062,085(-) GAAAG(A/C)AGAAA intron-variant
rs149595 -- 70,071,363(+) TGAAC(C/G)CTTAA intron-variant
rs150942 -- 70,075,385(-) GGATA(C/T)GCGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC8A3 Gene

Variant ID Type Subtype PubMed ID
nsv456336 CNV Gain 19166990
nsv832824 CNV Gain 17160897
nsv519644 CNV Loss 19592680
nsv832826 CNV Gain 17160897
esv2670724 CNV Deletion 23128226
esv1009218 CNV Insertion 20482838
nsv902075 CNV Gain 21882294
nsv1338 CNV Insertion 18451855

Variation tolerance for SLC8A3 Gene

Residual Variation Intolerance Score: 7.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC8A3 Gene

Disorders for SLC8A3 Gene

Relevant External Links for SLC8A3

Genetic Association Database (GAD)
SLC8A3
Human Genome Epidemiology (HuGE) Navigator
SLC8A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC8A3

No disorders were found for SLC8A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC8A3 Gene

Publications for SLC8A3 Gene

  1. Molecular cloning and characterization of two novel truncated isoforms of human Na+/Ca2+ exchanger 3, expressed in fetal brain. (PMID: 15777725) Lindgren R.M. … Nister M. (Gene 2005) 3 4 23 67
  2. Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins. (PMID: 16679322) Pulina M.V. … Carafoli E. (J. Biol. Chem. 2006) 3 23
  3. Transcriptional regulation by cAMP and Ca2+ links the Na+/Ca2+ exchanger 3 to memory and sensory pathways. (PMID: 15247490) Gabellini N. (Mol. Neurobiol. 2004) 3 23
  4. Control of the Na+/Ca2+ exchanger 3 promoter by cyclic adenosine monophosphate and Ca2+ in differentiating neurons. (PMID: 12558991) Gabellini N. … Carafoli E. (J. Neurochem. 2003) 3 23
  5. The human SLC8A3 gene and the tissue-specific Na+/Ca2+ exchanger 3 isoforms. (PMID: 12406570) Gabellini N. … Carafoli E. (Gene 2002) 3 23

Products for SLC8A3 Gene

Sources for SLC8A3 Gene

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