Aliases for SLC8A3 Gene
External Ids for SLC8A3 Gene
Previous GeneCards Identifiers for SLC8A3 Gene
This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013]
GeneCards Summary for SLC8A3 Gene
SLC8A3 (Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 3) is a Protein Coding gene. Among its related pathways are CREB Pathway and Platelet homeostasis. GO annotations related to this gene include calmodulin binding and calcium:cation antiporter activity. An important paralog of this gene is ADGRV1.
UniProtKB/Swiss-Prot for SLC8A3 Gene
Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity).
The Na+/Ca2+ exchanger (NCX) is a low affinity, high capacitance calcium antiporter membrane protein that functions to regulate intracellular calcium concentrations. It is located on the plasma, mitochondrial and endoplasmic reticular membranes of excitable cells.