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Aliases for SLC8A3 Gene

Aliases for SLC8A3 Gene

  • Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 3 2 3
  • Solute Carrier Family 8 Member 3 3 4
  • Na(+)/Ca(2+)-Exchange Protein 3 3 4
  • NCX3 3 4
  • Solute Carrier Family 8 (Sodium-Calcium Exchanger), Member 3 3
  • Sodium/Calcium Exchanger SLC8A3 3
  • Sodium/Calcium Exchanger 3 3
  • Na+/Ca2+ Exchanger 3 3

External Ids for SLC8A3 Gene

Previous GeneCards Identifiers for SLC8A3 Gene

  • GC14M068017
  • GC14M064307
  • GC14M068500
  • GC14M069580
  • GC14M070510
  • GC14M050679

Summaries for SLC8A3 Gene

Entrez Gene Summary for SLC8A3 Gene

  • This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013]

GeneCards Summary for SLC8A3 Gene

SLC8A3 (Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 3) is a Protein Coding gene. Among its related pathways are CREB Pathway and Platelet homeostasis. GO annotations related to this gene include calmodulin binding and calcium:sodium antiporter activity. An important paralog of this gene is ADGRV1.

UniProtKB/Swiss-Prot for SLC8A3 Gene

  • Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity).

Tocris Summary for SLC8A3 Gene

  • The Na+/Ca2+ exchanger (NCX) is a low affinity, high capacitance calcium antiporter membrane protein that functions to regulate intracellular calcium concentrations. It is located on the plasma, mitochondrial and endoplasmic reticular membranes of excitable cells. Using the electrochemical gradient of Na+, one Ca2+ ion is transported in exchange for three Na+ ions. The Na+/Ca2+ exchanger compliments the high affinity, low capacitance Ca2+-ATPase and together, they are involved in a variety of cellular functions including control of neurosecretion, relaxation of cardiac muscle, maintenance of intracellular Ca2+ stores in the endoplasmic and sarcoplasmic reticuli and excitation-relaxation coupling. Under normal physiological conditions, Na+/Ca2+ exchangers export Ca+ from the cell. However, under cellular stress, such as excitotoxicity, they can switch to 'reverse mode', which has a protective effect.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC8A3 Gene

Genomics for SLC8A3 Gene

Regulatory Elements for SLC8A3 Gene

Genomic Location for SLC8A3 Gene

Start:
70,044,217 bp from pter
End:
70,189,070 bp from pter
Size:
144,854 bases
Orientation:
Minus strand

Genomic View for SLC8A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC8A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC8A3 Gene

Proteins for SLC8A3 Gene

  • Protein details for SLC8A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57103-NAC3_HUMAN
    Recommended name:
    Sodium/calcium exchanger 3
    Protein Accession:
    P57103
    Secondary Accessions:
    • Q5K3P6
    • Q5K3P7
    • Q8IUE9
    • Q8IUF0
    • Q8NFI7
    • Q96QG1
    • Q96QG2

    Protein attributes for SLC8A3 Gene

    Size:
    927 amino acids
    Molecular mass:
    103010 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC8A3 Gene

neXtProt entry for SLC8A3 Gene

Proteomics data for SLC8A3 Gene at MOPED

Post-translational modifications for SLC8A3 Gene

  • Glycosylation at Asn45 and Asn823
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC8A3 Gene

Domains for SLC8A3 Gene

Gene Families for SLC8A3 Gene

Suggested Antigen Peptide Sequences for SLC8A3 Gene

Graphical View of Domain Structure for InterPro Entry

P57103

UniProtKB/Swiss-Prot:

NAC3_HUMAN :
  • P57103
Domain:
  • Contains 2 Calx-beta domains.
Family:
  • Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily.
genes like me logo Genes that share domains with SLC8A3: view

Function for SLC8A3 Gene

Molecular function for SLC8A3 Gene

GENATLAS Biochemistry: solute carrier family 8 (sodium-calcium exchange),member 3,expressed in brain and skeletal muscle
UniProtKB/Swiss-Prot EnzymeRegulation: By intracellular calcium ions.
UniProtKB/Swiss-Prot Function: Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity).

Gene Ontology (GO) - Molecular Function for SLC8A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005432 calcium:sodium antiporter activity IEA --
GO:0005516 calmodulin binding IEA --
GO:0015368 calcium:cation antiporter activity --
genes like me logo Genes that share ontologies with SLC8A3: view
genes like me logo Genes that share phenotypes with SLC8A3: view

Animal Models for SLC8A3 Gene

MGI Knock Outs for SLC8A3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC8A3 Gene

Localization for SLC8A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC8A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC8A3 Gene COMPARTMENTS Subcellular localization image for SLC8A3 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 2
mitochondrion 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC8A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005874 microtubule IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC8A3: view

Pathways for SLC8A3 Gene

genes like me logo Genes that share pathways with SLC8A3: view

Gene Ontology (GO) - Biological Process for SLC8A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006811 ion transport TAS --
GO:0006814 sodium ion transport --
GO:0006816 calcium ion transport --
GO:0007154 cell communication IEA --
genes like me logo Genes that share ontologies with SLC8A3: view

Compounds for SLC8A3 Gene

(4) Tocris Compounds for SLC8A3 Gene

Compound Action Cas Number
CGP 37157 Antagonist of mitochondrial Na+/Ca2+ exchange [75450-34-9]
KB-R7943 mesylate Na+/Ca2+ exchange inhibitor (reverse mode) [182004-65-5]
SN-6 Selective Na+/Ca2+ exchange inhibitor (reverse mode) [415697-08-4]
YM 244769 Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective [837424-39-2]

(2) HMDB Compounds for SLC8A3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Sodium
  • Sodium
7440-23-5

(3) Novoseek inferred chemical compound relationships for SLC8A3 Gene

Compound -log(P) Hits PubMed IDs
calcium 52.4 18
atp 23.7 1
sodium 0 1
genes like me logo Genes that share compounds with SLC8A3: view

Transcripts for SLC8A3 Gene

Unigene Clusters for SLC8A3 Gene

Solute carrier family 8 (sodium/calcium exchanger), member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC8A3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5:
SP6:

Relevant External Links for SLC8A3 Gene

GeneLoc Exon Structure for
SLC8A3
ECgene alternative splicing isoforms for
SLC8A3

Expression for SLC8A3 Gene

mRNA expression in normal human tissues for SLC8A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC8A3 Gene

This gene is overexpressed in Muscle - Skeletal (12.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC8A3 Gene

SOURCE GeneReport for Unigene cluster for SLC8A3 Gene Hs.337696

mRNA Expression by UniProt/SwissProt for SLC8A3 Gene

P57103-NAC3_HUMAN
Tissue specificity: Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle.
genes like me logo Genes that share expressions with SLC8A3: view

Orthologs for SLC8A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC8A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC8A3 35
  • 99.49 (n)
  • 100 (a)
SLC8A3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC8A3 35
  • 93.29 (n)
  • 97.19 (a)
SLC8A3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC8A3 35
  • 90.48 (n)
  • 93.29 (a)
SLC8A3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc8a3 35
  • 90.01 (n)
  • 95.13 (a)
Slc8a3 16
Slc8a3 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC8A3 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC8A3 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc8a3 35
  • 91.41 (n)
  • 97.51 (a)
chicken
(Gallus gallus)
Aves NCX3 36
  • 92 (a)
OneToOne
SLC8A3 35
  • 82.57 (n)
  • 92.05 (a)
lizard
(Anolis carolinensis)
Reptilia SLC8A3 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc8a3 35
  • 76.76 (n)
  • 88.67 (a)
zebrafish
(Danio rerio)
Actinopterygii slc8a3 35
  • 72.57 (n)
  • 79.43 (a)
slc8a3 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002859 35
  • 57.68 (n)
  • 54.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta Calx 35
  • 56.88 (n)
  • 51.37 (a)
Calx 36
  • 45 (a)
OneToMany
Calx 37
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea ncx-1 36
  • 48 (a)
ManyToMany
ncx-2 35
  • 56.15 (n)
  • 51.1 (a)
ncx-2 36
  • 46 (a)
ManyToMany
Y113G7A.4 37
  • 46 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2312 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
CSA.8047 36
  • 51 (a)
ManyToMany
Species with no ortholog for SLC8A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC8A3 Gene

ENSEMBL:
Gene Tree for SLC8A3 (if available)
TreeFam:
Gene Tree for SLC8A3 (if available)

Paralogs for SLC8A3 Gene

Paralogs for SLC8A3 Gene

Selected SIMAP similar genes for SLC8A3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC8A3: view

Variants for SLC8A3 Gene

Sequence variations from dbSNP and Humsavar for SLC8A3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2604 -- 70,145,242(+) CAAAA(C/T)TGAAT intron-variant
rs2605 -- 70,145,432(+) CCACA(G/T)TGGCA intron-variant
rs2893 -- 70,117,705(+) actca(A/C)cctgc intron-variant
rs149250 -- 70,062,738(-) GCTTT(C/G)TCTTT intron-variant
rs149251 -- 70,062,085(-) GAAAG(A/C)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC8A3 Gene

Variant ID Type Subtype PubMed ID
nsv456336 CNV Gain 19166990
nsv832824 CNV Gain 17160897
nsv519644 CNV Loss 19592680
nsv832826 CNV Gain 17160897
esv2670724 CNV Deletion 23128226
esv1009218 CNV Insertion 20482838
nsv902075 CNV Gain 21882294
nsv1338 CNV Insertion 18451855

Relevant External Links for SLC8A3 Gene

HapMap Linkage Disequilibrium report
SLC8A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC8A3 Gene

Disorders for SLC8A3 Gene

(2) Novoseek inferred disease relationships for SLC8A3 Gene

Disease -log(P) Hits PubMed IDs
cell damage 32.9 3
ischemia 7.61 2

Relevant External Links for SLC8A3

Genetic Association Database (GAD)
SLC8A3
Human Genome Epidemiology (HuGE) Navigator
SLC8A3
genes like me logo Genes that share disorders with SLC8A3: view

No data available for UniProtKB/Swiss-Prot for SLC8A3 Gene

Publications for SLC8A3 Gene

  1. The human SLC8A3 gene and the tissue-specific Na+/Ca2+ exchanger 3 isoforms. (PMID: 12406570) Gabellini N. … Carafoli E. (Gene 2002) 3 4 23
  2. Control of the Na+/Ca2+ exchanger 3 promoter by cyclic adenosine monophosphate and Ca2+ in differentiating neurons. (PMID: 12558991) Gabellini N. … Carafoli E. (J. Neurochem. 2003) 3 4 23
  3. Molecular cloning and characterization of two novel truncated isoforms of human Na+/Ca2+ exchanger 3, expressed in fetal brain. (PMID: 15777725) Lindgren R.M. … Nister M. (Gene 2005) 3 4 23
  4. Transcriptional regulation by cAMP and Ca2+ links the Na+/Ca2+ exchanger 3 to memory and sensory pathways. (PMID: 15247490) Gabellini N. (Mol. Neurobiol. 2004) 3 23
  5. The gene promoter of human Na+/Ca2+ exchanger isoform 3 (SLC8A3) is controlled by cAMP and calcium. (PMID: 12502570) Gabellini N. … Carafoli E. (Ann. N. Y. Acad. Sci. 2002) 3 23

Products for SLC8A3 Gene

Sources for SLC8A3 Gene

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