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Aliases for SLC8A3 Gene

Aliases for SLC8A3 Gene

  • Solute Carrier Family 8 Member A3 2 3 5
  • Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 3 2 3
  • Na(+)/Ca(2+)-Exchange Protein 3 3 4
  • NCX3 3 4
  • Solute Carrier Family 8 Member 3 4
  • Sodium/Calcium Exchanger SLC8A3 3
  • Sodium/Calcium Exchanger 3 3

External Ids for SLC8A3 Gene

Previous GeneCards Identifiers for SLC8A3 Gene

  • GC14M068017
  • GC14M064307
  • GC14M068500
  • GC14M069580
  • GC14M070510
  • GC14M050679

Summaries for SLC8A3 Gene

Entrez Gene Summary for SLC8A3 Gene

  • This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013]

GeneCards Summary for SLC8A3 Gene

SLC8A3 (Solute Carrier Family 8 Member A3) is a Protein Coding gene. Diseases associated with SLC8A3 include Spastic Paraplegia 24, Autosomal Recessive. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Collagen chain trimerization. GO annotations related to this gene include calmodulin binding and calcium:cation antiporter activity. An important paralog of this gene is SLC8A1.

UniProtKB/Swiss-Prot for SLC8A3 Gene

  • Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity).

Tocris Summary for SLC8A3 Gene

  • The Na+/Ca2+ exchanger (NCX) is a low affinity, high capacitance calcium antiporter membrane protein that functions to regulate intracellular calcium concentrations. It is located on the plasma, mitochondrial and endoplasmic reticular membranes of excitable cells.

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC8A3 Gene

Genomics for SLC8A3 Gene

Regulatory Elements for SLC8A3 Gene

Enhancers for SLC8A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G070254 1.1 Ensembl ENCODE 12.1 -31.5 -31526 1.5 ELF3 TBP NFIB ARID4B SIN3A DMAP1 RAD21 ZNF48 YY1 SLC30A9 COX16 SLC8A3 RNU2-51P ADAM20 ENSG00000258422 LOC101928046 ADAM21P1
GH14G070004 1.2 ENCODE dbSUPER 10.1 +218.2 218160 1.5 PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 SP5 JUNB PPARG SMOC1 SLC8A3 GC14M069988 GC14M070040
GH14G070358 1.2 ENCODE 5.6 -135.9 -135853 1.8 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 MED6 COX16 PTTG4P RPL7AP6 SUSD6 KRT18P7 ERH SLC8A3 PIR53064
GH14G070121 0.5 ENCODE 11.1 +101.9 101894 0.2 RFX1 MAX EP300 SLC8A3 GC14M070128 GC14M070040
GH14G070317 1 ENCODE 5.5 -94.6 -94615 1.7 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF143 REST MIER2 COX16 RNU2-51P SLC8A3 ADAM20P1 ADAM21 PIR53064 LOC105370552
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC8A3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC8A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000070305 111 600 CTCF LEF1 ATF1 ZNF384 ZBTB40 CHAMP1 POLR2A ZSCAN29 PRDM10 CREM

Genomic Location for SLC8A3 Gene

Chromosome:
14
Start:
70,044,217 bp from pter
End:
70,223,612 bp from pter
Size:
179,396 bases
Orientation:
Minus strand

Genomic View for SLC8A3 Gene

Genes around SLC8A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC8A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC8A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC8A3 Gene

Proteins for SLC8A3 Gene

  • Protein details for SLC8A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57103-NAC3_HUMAN
    Recommended name:
    Sodium/calcium exchanger 3
    Protein Accession:
    P57103
    Secondary Accessions:
    • Q5K3P6
    • Q5K3P7
    • Q8IUE9
    • Q8IUF0
    • Q8NFI7
    • Q96QG1
    • Q96QG2

    Protein attributes for SLC8A3 Gene

    Size:
    927 amino acids
    Molecular mass:
    103010 Da
    Quaternary structure:
    • Interacts with AKAP1.

    Alternative splice isoforms for SLC8A3 Gene

neXtProt entry for SLC8A3 Gene

Post-translational modifications for SLC8A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC8A3 Gene

Domains & Families for SLC8A3 Gene

Gene Families for SLC8A3 Gene

Suggested Antigen Peptide Sequences for SLC8A3 Gene

Graphical View of Domain Structure for InterPro Entry

P57103

UniProtKB/Swiss-Prot:

NAC3_HUMAN :
  • The cytoplasmic Calx-beta domains bind the regulatory Ca(2+). The first Calx-beta domain can bind up to four Ca(2+) ions. The second domain can bind another two Ca(2+) ions that are essential for calcium-regulated ion exchange.
  • Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
Domain:
  • The cytoplasmic Calx-beta domains bind the regulatory Ca(2+). The first Calx-beta domain can bind up to four Ca(2+) ions. The second domain can bind another two Ca(2+) ions that are essential for calcium-regulated ion exchange.
Family:
  • Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
genes like me logo Genes that share domains with SLC8A3: view

Function for SLC8A3 Gene

Molecular function for SLC8A3 Gene

GENATLAS Biochemistry:
solute carrier family 8 (sodium-calcium exchange),member 3,expressed in brain and skeletal muscle
UniProtKB/Swiss-Prot EnzymeRegulation:
Calcium transport is down-regulated by Na(+) and stimulated by Ca(2+).
UniProtKB/Swiss-Prot Function:
Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity).

Gene Ontology (GO) - Molecular Function for SLC8A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005432 calcium:sodium antiporter activity TAS --
GO:0005516 calmodulin binding IEA --
GO:0015297 antiporter activity IEA --
GO:0015368 calcium:cation antiporter activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SLC8A3: view
genes like me logo Genes that share phenotypes with SLC8A3: view

Animal Models for SLC8A3 Gene

MGI Knock Outs for SLC8A3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC8A3 Gene

Localization for SLC8A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC8A3 Gene

Cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection, dendrite. Cell projection, dendritic spine. Cell membrane, sarcolemma. Cytoplasm, sarcoplasm. Cell junction. Mitochondrion outer membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Detected at neuromuscular junctions. {ECO:0000250 UniProtKB:S4R2P9}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC8A3 gene
Compartment Confidence
plasma membrane 5
mitochondrion 5
endoplasmic reticulum 5
cytoskeleton 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC8A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane ISS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane ISS --
genes like me logo Genes that share ontologies with SLC8A3: view

Pathways & Interactions for SLC8A3 Gene

genes like me logo Genes that share pathways with SLC8A3: view

Gene Ontology (GO) - Biological Process for SLC8A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006810 transport IEA --
GO:0006811 ion transport TAS --
GO:0006814 sodium ion transport IEA --
GO:0006816 calcium ion transport IEA --
genes like me logo Genes that share ontologies with SLC8A3: view

No data available for SIGNOR curated interactions for SLC8A3 Gene

Drugs & Compounds for SLC8A3 Gene

(9) Drugs for SLC8A3 Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chlorthalidone Approved Pharma 64
Benzamil Pharma Channel blocker NCX inhibitor, Deg/ENaC channel blocker; amiloride (Cat. No. 0890) derivative 0
CGP 37157 Pharma Antagonist of mitochondrial Na+-Ca2+ exchanger, Antagonist of mitochondrial Na+/Ca2+ exchange 0
KB-R7943 mesylate Pharma Inhibitor of the reverse mode of the Na+/Ca2+ exchanger, Na+/Ca2+ exchange inhibitor (reverse mode) 0
SN-6 Pharma Selective Na+/Ca2+ exchange inhibitor (reverse mode) 0

(1) Additional Compounds for SLC8A3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5

(5) Tocris Compounds for SLC8A3 Gene

Compound Action Cas Number
Benzamil NCX inhibitor, Deg/ENaC channel blocker; amiloride (Cat. No. 0890) derivative 161804-20-2
CGP 37157 Antagonist of mitochondrial Na+/Ca2+ exchange 75450-34-9
KB-R7943 mesylate Na+/Ca2+ exchange inhibitor (reverse mode) 182004-65-5
SN-6 Selective Na+/Ca2+ exchange inhibitor (reverse mode) 415697-08-4
YM 244769 Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective 837424-39-2

(7) ApexBio Compounds for SLC8A3 Gene

Compound Action Cas Number
Benzamil 161804-20-2
CGP 37157 Antagonist of mitochondrial Na+-Ca2+ exchanger 75450-34-9
Chlorthalidone 77-36-1
KB-R7943 mesylate Inhibitor of the reverse mode of the Na+/Ca2+ exchanger 182004-65-5
SN-6 415697-08-4
YM 244769 837424-39-2
Zoniporide dihydrochloride 241799-10-0
genes like me logo Genes that share compounds with SLC8A3: view

Drug Products

Transcripts for SLC8A3 Gene

Unigene Clusters for SLC8A3 Gene

Solute carrier family 8 (sodium/calcium exchanger), member 3:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC8A3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5:
SP6:

Relevant External Links for SLC8A3 Gene

GeneLoc Exon Structure for
SLC8A3
ECgene alternative splicing isoforms for
SLC8A3

Expression for SLC8A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC8A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC8A3 Gene

This gene is overexpressed in Muscle - Skeletal (x12.9).

Protein differential expression in normal tissues from HIPED for SLC8A3 Gene

This gene is overexpressed in Frontal cortex (38.4), Retina (17.3), and Heart (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC8A3 Gene



Protein tissue co-expression partners for SLC8A3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC8A3 Gene:

SLC8A3

SOURCE GeneReport for Unigene cluster for SLC8A3 Gene:

Hs.337696

mRNA Expression by UniProt/SwissProt for SLC8A3 Gene:

P57103-NAC3_HUMAN
Tissue specificity: Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle.

Evidence on tissue expression from TISSUES for SLC8A3 Gene

  • Nervous system(4.7)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with SLC8A3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC8A3 Gene

Orthologs for SLC8A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC8A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC8A3 34 35
  • 99.49 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC8A3 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC8A3 34 35
  • 93.29 (n)
rat
(Rattus norvegicus)
Mammalia Slc8a3 34
  • 91.41 (n)
dog
(Canis familiaris)
Mammalia SLC8A3 34 35
  • 90.48 (n)
mouse
(Mus musculus)
Mammalia Slc8a3 34 16 35
  • 90.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC8A3 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCX3 35
  • 92 (a)
OneToOne
SLC8A3 34
  • 82.57 (n)
lizard
(Anolis carolinensis)
Reptilia SLC8A3 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc8a3 34
  • 76.76 (n)
zebrafish
(Danio rerio)
Actinopterygii slc8a3 34 35
  • 72.57 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002859 34
  • 57.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta Calx 36 34 35
  • 56.88 (n)
worm
(Caenorhabditis elegans)
Secernentea ncx-2 34 35
  • 56.15 (n)
ncx-1 35
  • 48 (a)
ManyToMany
Y113G7A.4 36
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 72 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
CSA.8047 35
  • 51 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2312 34
Species where no ortholog for SLC8A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC8A3 Gene

ENSEMBL:
Gene Tree for SLC8A3 (if available)
TreeFam:
Gene Tree for SLC8A3 (if available)

Paralogs for SLC8A3 Gene

Paralogs for SLC8A3 Gene

(4) SIMAP similar genes for SLC8A3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC8A3: view

Variants for SLC8A3 Gene

Sequence variations from dbSNP and Humsavar for SLC8A3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_036463 A breast cancer sample
rs76086886 Uncertain significance 70,166,733(+) GGGGA(C/T)GATGA nc-transcript-variant, reference, missense
rs1000010568 -- 70,138,581(+) TCCTG(A/G)AAGGT intron-variant
rs1000011775 -- 70,096,951(+) GGGGA(C/T)CAACT intron-variant
rs1000041480 -- 70,178,112(+) TCCAC(G/T)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC8A3 Gene

Variant ID Type Subtype PubMed ID
esv1009218 CNV insertion 20482838
esv2670724 CNV deletion 23128226
esv3634850 CNV loss 21293372
esv3634851 CNV loss 21293372
esv3634852 CNV loss 21293372
nsv1338 CNV insertion 18451855
nsv456336 CNV gain 19166990
nsv472023 CNV novel sequence insertion 20440878
nsv476500 CNV novel sequence insertion 20440878
nsv519644 CNV loss 19592680
nsv565007 CNV gain 21841781
nsv832824 CNV gain 17160897
nsv832826 CNV gain 17160897

Variation tolerance for SLC8A3 Gene

Residual Variation Intolerance Score: 7.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC8A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC8A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC8A3 Gene

Disorders for SLC8A3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC8A3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spastic paraplegia 24, autosomal recessive
  • hereditary spastic paraplegia 24
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC8A3

Genetic Association Database (GAD)
SLC8A3
Human Genome Epidemiology (HuGE) Navigator
SLC8A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC8A3
genes like me logo Genes that share disorders with SLC8A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC8A3 Gene

Publications for SLC8A3 Gene

  1. Molecular cloning and characterization of two novel truncated isoforms of human Na+/Ca2+ exchanger 3, expressed in fetal brain. (PMID: 15777725) Lindgren R.M. … Nister M. (Gene 2005) 3 4 22 64
  2. Control of the Na+/Ca2+ exchanger 3 promoter by cyclic adenosine monophosphate and Ca2+ in differentiating neurons. (PMID: 12558991) Gabellini N. … Carafoli E. (J. Neurochem. 2003) 3 4 22 64
  3. The human SLC8A3 gene and the tissue-specific Na+/Ca2+ exchanger 3 isoforms. (PMID: 12406570) Gabellini N. … Carafoli E. (Gene 2002) 3 4 22 64
  4. Silencing or knocking out the Na(+)/Ca(2+) exchanger-3 (NCX3) impairs oligodendrocyte differentiation. (PMID: 21959935) Boscia F. … Annunziato L. (Cell Death Differ. 2012) 3 4 64
  5. Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2. (PMID: 21602797) Wright F.A. … Cutting G.R. (Nat. Genet. 2011) 3 46 64

Products for SLC8A3 Gene

Sources for SLC8A3 Gene

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