Aliases for SLC8A3 Gene
External Ids for SLC8A3 Gene
Previous GeneCards Identifiers for SLC8A3 Gene
This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013]
GeneCards Summary for SLC8A3 Gene
SLC8A3 (Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 3) is a Protein Coding gene. Among its related pathways are CREB Pathway and Platelet homeostasis. GO annotations related to this gene include calmodulin binding and calcium:sodium antiporter activity. An important paralog of this gene is ADGRV1.
UniProtKB/Swiss-Prot for SLC8A3 Gene
Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity).
The Na+/Ca2+ exchanger (NCX) is a low affinity, high capacitance calcium antiporter membrane protein that functions to regulate intracellular calcium concentrations. It is located on the plasma, mitochondrial and endoplasmic reticular membranes of excitable cells. Using the electrochemical gradient of Na+, one Ca2+ ion is transported in exchange for three Na+ ions. The Na+/Ca2+ exchanger compliments the high affinity, low capacitance Ca2+-ATPase and together, they are involved in a variety of cellular functions including control of neurosecretion, relaxation of cardiac muscle, maintenance of intracellular Ca2+ stores in the endoplasmic and sarcoplasmic reticuli and excitation-relaxation coupling. Under normal physiological conditions, Na+/Ca2+ exchangers export Ca+ from the cell. However, under cellular stress, such as excitotoxicity, they can switch to 'reverse mode', which has a protective effect.