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SLC8A2 Gene

protein-coding   GIFtS: 64
GCID: GC19M047931

Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 21 2     Sodium-Calcium Exchanger 22
NCX22 3 5     Sodium/Calcium Exchanger 22
Solute Carrier Family 8 Member 22 3     Solute Carrier Family 8 (Sodium-Calcium Exchanger), Member 22
Na(+)/Ca(2+)-Exchange Protein 22 3     KIAA10873
Na+/Ca2+-Exchanging Protein Nac22     

External Ids:    HGNC: 110691   Entrez Gene: 65432   Ensembl: ENSG000001181607   OMIM: 6019015   UniProtKB: Q9UPR53   

Export aliases for SLC8A2 gene to outside databases

Previous GC identifers: GC19M048578 GC19M048322 GC19M052607 GC19M052623 GC19M044359


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC8A2 Gene:
SLC8A2 (solute carrier family 8 (sodium/calcium exchanger), member 2) is a protein-coding gene. Diseases associated with SLC8A2 include anoxia, and cerebral artery occlusion. GO annotations related to this gene include calcium:sodium antiporter activity and calmodulin binding. An important paralog of this gene is SLC8A3.

UniProtKB/Swiss-Prot: NAC2_HUMAN, Q9UPR5
Function: Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell
during relaxation so as to prevent overloading of intracellular stores (By similarity)

summary for SLC8A2 Gene:
The Na+/Ca2+ exchanger (NCX) is a low affinity, high capacitance calcium antiporter membrane protein that
functions to regulate intracellular calcium concentrations. It is located on the plasma, mitochondrial and
endoplasmic reticular membranes of excitable cells. Using the electrochemical gradient of Na+, one Ca2+ ion
is transported in exchange for three Na+ ions. The Na+/Ca2+ exchanger compliments the high affinity, low
capacitance Ca2+-ATPase and together, they are involved in a variety of cellular functions including control
of neurosecretion, relaxation of cardiac muscle, maintenance of intracellular Ca2+ stores in the endoplasmic
and sarcoplasmic reticuli and excitation-relaxation coupling. Under normal physiological conditions,
Na+/Ca2+ exchangers export Ca+ from the cell. However, under cellular stress, such as excitotoxicity, they
can switch to 'reverse mode', which has a protective effect.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC8A2 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B2   oct-B3   GATA-1   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC8A2 promoter sequence
   Search Chromatin IP Primers for SLC8A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC8A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

SLC8A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC8A2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M047931:  view genomic region     (about GC identifiers)

Start:
47,931,274 bp from pter      End:
47,975,425 bp from pter
Size:
44,152 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NAC2_HUMAN, Q9UPR5 (See protein sequence)
Recommended Name: Sodium/calcium exchanger 2 precursor  
Size: 921 amino acids; 100368 Da
Sequence caution: Sequence=BAA83039.1; Type=Erroneous initiation;
Secondary accessions: B4DYQ9

Explore the universe of human proteins at neXtProt for SLC8A2: NX_Q9UPR5

Explore proteomics data for SLC8A2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn34, Asn817
  • Modification sites at PhosphoSitePlus

  • See SLC8A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055878.1  
    ENSEMBL proteins: 
     ENSP00000236877   ENSP00000440588   ENSP00000437536   ENSP00000472233   ENSP00000472208  
    Reactome Protein details: Q9UPR5

    SLC8A2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Sodium/calcium exchanger 2
    SLC8 family of sodium/calcium exchangers

    3 InterPro protein domains:
     IPR003644 Calx_beta
     IPR004837 NaCa_Exmemb
     IPR004836 Na_Ca_Ex

    Graphical View of Domain Structure for InterPro Entry Q9UPR5

    ProtoNet protein and cluster: Q9UPR5

    3 Blocks protein domains:
    IPB003644 Na-Ca exchanger/integrin-beta4
    IPB004836 Na+/Ca2+ exchanger signature
    IPB004837 Sodium/calcium exchanger membrane region


    UniProtKB/Swiss-Prot: NAC2_HUMAN, Q9UPR5
    Similarity: Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily
    Similarity: Contains 2 Calx-beta domains


    SLC8A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAC2_HUMAN, Q9UPR5
    Function: Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell
    during relaxation so as to prevent overloading of intracellular stores (By similarity)
    Enzyme regulation: By ATP (By similarity)

         Genatlas biochemistry entry for SLC8A2:
    solute carrier family 8 (sodium-calcium exchange),member 2,brain

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005432calcium:sodium antiporter activity IEA--
    GO:0005516calmodulin binding IEA--
         
    SLC8A2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC8A2:
     Increased circadian rhythm amp 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc8a2):
     behavior/neurological  nervous system 

    SLC8A2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC8A2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC8A2
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLC8A2 (see all 58):
    hsa-miR-576-3p hsa-miR-607 hsa-miR-330-5p hsa-let-7d hsa-miR-502-3p hsa-miR-877* hsa-miR-4314 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidSLC8A2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SLC8A2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC8A2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NAC2_HUMAN, Q9UPR5: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    SLC8A2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC8A2 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Sodium/Calcium exchangers0.00
    2Platelet homeostasis
    Platelet homeostasis
    Platelet calcium homeostasis0.00
    Reduction of cytosolic Ca++ levels0.00
    3CREB Pathway
    Intracellular Calcium Signaling0.50
    4Hemostasis
    Hemostasis0.43
    5fMLP Pathway
    Alpha-Adrenergic Signaling0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SLC8A2
        Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    Alpha-Adrenergic Signaling

    2 Reactome Pathways for SLC8A2
        Sodium/Calcium exchangers
    Reduction of cytosolic Ca++ levels

    1 PharmGKB Pathway for SLC8A2
        Antiarrhythmic Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for SLC8A2):
        Calcium signaling pathway
    Protein digestion and absorption


    SLC8A2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC8A2
    Interactions:

        Search GeneGlobe Interaction Network for SLC8A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for SLC8A2 (Q9UPR53 ENSP000002368774) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP3CBP162983, ENSP000003783064I2D: score=1 STRING: ENSP00000378306
    YWHABP319463, ENSP000003001614I2D: score=1 STRING: ENSP00000300161
    YWHAEP622583, ENSP000002643354I2D: score=1 STRING: ENSP00000264335
    YWHAQP273483, ENSP000002380814I2D: score=1 STRING: ENSP00000238081
    YWHAZP631043, ENSP000003095034I2D: score=1 STRING: ENSP00000309503
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006816calcium ion transport ----
    GO:0007154cell communication IEA--
    GO:0007596blood coagulation TAS--
    GO:0055085transmembrane transport TAS--

    SLC8A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for SLC8A2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    KB-R7943 mesylateNa+/Ca2+ exchange inhibitor (reverse mode)[182004-65-5]
    YM 244769Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective[837424-39-2]
    SN-6Selective Na+/Ca2+ exchange inhibitor (reverse mode)[415697-08-4]
    CGP 37157Antagonist of mitochondrial Na+/Ca2+ exchange[75450-34-9]

    2 HMDB Compounds for SLC8A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    SodiumSodium (see all 2)7440-23-5--

    2 Novoseek inferred chemical compound relationships for SLC8A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 45.5 21 8021246 (4), 16679322 (3), 9486131 (2), 17446490 (2) (see all 8)
    atp 26.9 1 9486131 (1)



    SLC8A2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC8A2 gene: 
    NM_015063.2  

    Unigene Cluster for SLC8A2:

    Solute carrier family 8 (sodium/calcium exchanger), member 2
    Hs.172884  [show with all ESTs]
    Unigene Representative Sequence: NM_015063
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000236877(uc010ele.3 uc002pgx.3 uc010xyq.2 uc010xyr.2)
    ENST00000539381 ENST00000542837 ENST00000600576 ENST00000601757 ENST00000594353
    ENST00000597014

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    Selected qRT-PCR Assays for microRNAs that regulate SLC8A2 (see all 58):
    hsa-miR-576-3p hsa-miR-607 hsa-miR-330-5p hsa-let-7d hsa-miR-502-3p hsa-miR-877* hsa-miR-4314 hsa-let-7g
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    Additional mRNA sequence: 

    AB029010.1 AK293457.1 AK293836.1 AK293860.1 AK302552.1 AL512764.1 

    3 DOTS entries:

    DT.432581  DT.40310525  DT.121500847 

    Selected AceView cDNA sequences (see all 32):

    BM676384 AI457394 BM069629 BM127959 BU738783 BI789259 BI962768 AL512764 
    AI127885 BM069886 CK819267 BG772726 BX110856 BM128286 AB029010 AA365850 
    AA398184 AA326195 H50909 AA028942 AI631453 BM713267 R87591 BI964750 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC8A2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                                            
    SP2:        -                                                   
    SP3:                                                            
    SP4:                                                            


    ECgene alternative splicing isoforms for SLC8A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC8A2 expression in normal human tissues (normalized intensities)      SLC8A2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCACAAAC
    SLC8A2 Expression
    About this image


    SLC8A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Olfactory Bulb   
     
     Pancreas (Endocrine System)
    SLC8A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC8A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.172884
        Custom PCR Arrays for SLC8A2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC8A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC8A2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc8a21 , 5 solute carrier family 8 (sodium/calcium exchanger), member 2 less1, 5 88.2(n)1
    94.46(a)1
      7 (8.75 cM)5
    1108911  NM_148946.21  NP_683748.11 
     161303005 
    lizard
    (Anolis carolinensis)
    Reptilia SLC8A26
    solute carrier family 8 (sodium/calcium exchanger)...
    87(a)
    1 ↔ 1
    GL343564.1(373307-405155)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc8a21 solute carrier family 8 (sodium/calcium exchanger), member 2 less 68.81(n)
    77.65(a)
      100495074  XM_002939246.2  XP_002939292.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc8a2b1 solute carrier family 8 (sodium-calcium exchanger), member 2b less 72.78(n)
    73.77(a)
      567212  NM_001123284.1  NP_001116756.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Calx3 calcium:sodium antiporter 48(a)   93B3   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y113G7A.43   -- 47(a)   V(20097897-20112759)   --


    ENSEMBL Gene Tree for SLC8A2 (if available)
    TreeFam Gene Tree for SLC8A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC8A2 gene
    SLC8A32  SLC8A12  GPR982  
    5 SIMAP similar genes for SLC8A2 using alignment to 5 protein entries:     NAC2_HUMAN (see all proteins):
    DKFZp761D171    SLC8A3    DKFZp779F0871    NACAIS4    SLC8A1

    SLC8A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC8A2 (see all 996)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2074772341,2
    Cuntested147952723(+) ACAGGC/TGCCTG 1 -- int10--------
    rs1461175681,2
    --47930791(+) CTACTC/GCGTTT 1 -- ds50010--------
    rs1401946771,2
    --47930932(+) GTCTGC/TTGCCT 1 -- ds50010--------
    rs1422407231,2
    C--47931034(+) GCCTCC/GTTCCC 1 -- ds50010--------
    rs1807314251,2
    C--47931111(+) GATAAA/TGTCTC 1 -- ds50010--------
    rs1866472761,2
    --47931141(+) TCACTC/TCCCAC 1 -- ds50010--------
    rs1459507531,2
    --47931170(+) ATGATA/GACCAT 1 -- ds50010--------
    rs169722141,2
    C,F,H--47931183(+) CCAGGG/ACTCTG 1 -- ds500119Minor allele frequency- A:0.37NA EA NS WA CSA 1404
    rs570597501,2
    C--47931246(+) GCACAAC/-ACACA 1 -- ds50011Minor allele frequency- -:0.00CSA 2
    rs2019859951,2
    C--47931261(+) ACACA-/CCCCCCT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SLC8A2 (47931274 - 47975425 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SLC8A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1000004CNV Deletion20482838
    esv1055822CNV Deletion17803354
    esv2718663CNV Deletion23290073
    nsv912202CNV Loss21882294
    nsv517901CNV Loss19592680
    nsv912201CNV Loss21882294
    nsv428366CNV Loss18775914
    dgv1107e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC8A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC8A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601901    OMIM disorders: --

    10 diseases for SLC8A2:    About MalaCards
    anoxia    cerebral artery occlusion    brain ischemia    ischemia
    hypoxia    cerebritis    retinitis    alzheimer's disease
    parkinson's disease    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SLC8A2:
    Brain ischemia

    SLC8A2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for SLC8A2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ischemia 20.3 1 15472108 (1)

    Genetic Association Database (GAD): SLC8A2
    Human Genome Epidemiology (HuGE) Navigator: SLC8A2 (4 documents)

    Export disorders for SLC8A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC8A2 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with SLC8A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the NCX2 isoform of the plasma membrane Na(+)-Ca2+ exchanger. (PubMed id 8021246)1, 3, 9 Li Z....Philipson K.D. (J. Biol. Chem. 1994)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    4. Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins. (PubMed id 16679322)1, 9 Pulina M.V....Carafoli E. (J. Biol. Chem. 2006)
    5. Immunosuppressive drugs, immunophilins, and functional expression of NCX isoforms. (PubMed id 23224887)1 Rahamimoff H....Elmaz D. (Adv. Exp. Med. Biol. 2013)
    6. New roles of NCX in glial cells: activation of microglia in ischemia and differentiation of oligodendrocytes. (PubMed id 23224890)1 Boscia F....Annunziato L. (Adv. Exp. Med. Biol. 2013)
    7. The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease. (PubMed id 23224884)1 Wood-Kaczmar A....Abramov A.Y. (Adv. Exp. Med. Biol. 2013)
    8. High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease. (PubMed id 21382638)1 Sokolow S....Gylys K.H. (Cell Calcium 2011)
    9. Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle. (PubMed id 21858195)1 Sathish V....Prakash Y.S. (PLoS ONE 2011)
    10. Molecular genetic and epigenetic analysis of NCX2/SLC8A2 at 19q13.3 in human gliomas. (PubMed id 20132488)1 Qu M....NistAcr M. (Neuropathol. Appl. Neurobiol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6543 HGNC: 11069 AceView: SLC8A2 Ensembl:ENSG00000118160 euGenes: HUgn6543
    ECgene: SLC8A2 Kegg: 6543 H-InvDB: SLC8A2

    (According to HUGE)
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    HUGE: KIAA1087

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC8A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC8A2 gene:
    Search GeneIP for patents involving SLC8A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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