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Aliases for SLC8A2 Gene

Aliases for SLC8A2 Gene

  • Solute Carrier Family 8 Member A2 2 3
  • Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 2 2 3 5
  • Solute Carrier Family 8 Member 2 3 4
  • Na(+)/Ca(2+)-Exchange Protein 2 3 4
  • NCX2 3 4
  • Solute Carrier Family 8 (Sodium-Calcium Exchanger), Member 2 3
  • Na+/Ca2+-Exchanging Protein Nac2 3
  • Sodium-Calcium Exchanger 2 3
  • KIAA1087 4

External Ids for SLC8A2 Gene

Previous GeneCards Identifiers for SLC8A2 Gene

  • GC19M048578
  • GC19M048322
  • GC19M052607
  • GC19M052623
  • GC19M047931
  • GC19M044359

Summaries for SLC8A2 Gene

GeneCards Summary for SLC8A2 Gene

SLC8A2 (Solute Carrier Family 8 Member A2) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include calmodulin binding and calcium:sodium antiporter activity. An important paralog of this gene is ADGRV1.

UniProtKB/Swiss-Prot for SLC8A2 Gene

  • Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion.

Tocris Summary for SLC8A2 Gene

  • The Na+/Ca2+ exchanger (NCX) is a low affinity, high capacitance calcium antiporter membrane protein that functions to regulate intracellular calcium concentrations. It is located on the plasma, mitochondrial and endoplasmic reticular membranes of excitable cells.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC8A2 Gene

Genomics for SLC8A2 Gene

Regulatory Elements for SLC8A2 Gene

Genomic Location for SLC8A2 Gene

Chromosome:
19
Start:
47,428,017 bp from pter
End:
47,472,168 bp from pter
Size:
44,152 bases
Orientation:
Minus strand

Genomic View for SLC8A2 Gene

Genes around SLC8A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC8A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC8A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC8A2 Gene

Proteins for SLC8A2 Gene

  • Protein details for SLC8A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPR5-NAC2_HUMAN
    Recommended name:
    Sodium/calcium exchanger 2
    Protein Accession:
    Q9UPR5
    Secondary Accessions:
    • B4DYQ9

    Protein attributes for SLC8A2 Gene

    Size:
    921 amino acids
    Molecular mass:
    100368 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA83039.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC8A2 Gene

Proteomics data for SLC8A2 Gene at MOPED

Post-translational modifications for SLC8A2 Gene

  • Glycosylation at Asn 34 and Asn 817
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC8A2 Gene

No data available for DME Specific Peptides for SLC8A2 Gene

Domains & Families for SLC8A2 Gene

Gene Families for SLC8A2 Gene

Suggested Antigen Peptide Sequences for SLC8A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UPR5

UniProtKB/Swiss-Prot:

NAC2_HUMAN :
  • The cytoplasmic Calx-beta domains bind the regulatory Ca(2+). The first Calx-beta domain can bind up to four Ca(2+) ions. The second domain can bind another two Ca(2+) ions that are essential for calcium-regulated ion exchange.
  • Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily.
Domain:
  • The cytoplasmic Calx-beta domains bind the regulatory Ca(2+). The first Calx-beta domain can bind up to four Ca(2+) ions. The second domain can bind another two Ca(2+) ions that are essential for calcium-regulated ion exchange.
  • Contains 2 Calx-beta domains.
Family:
  • Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily.
genes like me logo Genes that share domains with SLC8A2: view

Function for SLC8A2 Gene

Molecular function for SLC8A2 Gene

GENATLAS Biochemistry:
solute carrier family 8 (sodium-calcium exchange),member 2,brain
UniProtKB/Swiss-Prot EnzymeRegulation:
Calcium transport is down-regulated by Na(+) and stimulated by Ca(2+).
UniProtKB/Swiss-Prot Function:
Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion.

Phenotypes for SLC8A2 Gene

MGI mutant phenotypes for SLC8A2:
inferred from 1 alleles
GenomeRNAi human phenotypes for SLC8A2:
genes like me logo Genes that share phenotypes with SLC8A2: view

Animal Model Products

CRISPR Products

miRNA for SLC8A2 Gene

miRTarBase miRNAs that target SLC8A2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC8A2 Gene

Localization for SLC8A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC8A2 Gene

Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection, dendrite. Cell projection, dendritic spine.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC8A2 Gene COMPARTMENTS Subcellular localization image for SLC8A2 gene
Compartment Confidence
plasma membrane 5
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SLC8A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC8A2: view

Pathways & Interactions for SLC8A2 Gene

genes like me logo Genes that share pathways with SLC8A2: view

Gene Ontology (GO) - Biological Process for SLC8A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007154 cell communication IEA --
GO:0007596 blood coagulation TAS --
GO:0035725 sodium ion transmembrane transport IEA,ISS --
GO:0055085 transmembrane transport IEA --
GO:1903779 regulation of cardiac conduction TAS --
genes like me logo Genes that share ontologies with SLC8A2: view

No data available for SIGNOR curated interactions for SLC8A2 Gene

Drugs & Compounds for SLC8A2 Gene

(3) Drugs for SLC8A2 Gene - From: Novoseek, Tocris, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
Benzamil Pharma Channel blocker NCX inhibitor, Deg/ENaC channel blocker; amiloride (Cat. No. 0890) derivative 0

(5) Additional Compounds for SLC8A2 Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
Bepridil hydrochloride
68099-86-5
CGP 37157
75450-34-9
KB-R7943 mesylate
182004-65-5
SN-6
415697-08-4
genes like me logo Genes that share compounds with SLC8A2: view

Transcripts for SLC8A2 Gene

Unigene Clusters for SLC8A2 Gene

Solute carrier family 8 (sodium/calcium exchanger), member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC8A2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for SLC8A2 Gene

GeneLoc Exon Structure for
SLC8A2
ECgene alternative splicing isoforms for
SLC8A2

Expression for SLC8A2 Gene

mRNA expression in normal human tissues for SLC8A2 Gene

mRNA differential expression in normal tissues according to GTEx for SLC8A2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x10.4), Brain - Cerebellum (x9.9), Brain - Cortex (x5.1), Brain - Frontal Cortex (BA9) (x4.6), and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for SLC8A2 Gene

This gene is overexpressed in Frontal cortex (43.3) and Brain (23.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC8A2 Gene



SOURCE GeneReport for Unigene cluster for SLC8A2 Gene Hs.172884

genes like me logo Genes that share expression patterns with SLC8A2: view

Protein tissue co-expression partners for SLC8A2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC8A2 Gene

Orthologs for SLC8A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC8A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC8A2 35
  • 93.92 (n)
  • 98.05 (a)
SLC8A2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc8a2 35
  • 88.2 (n)
  • 94.46 (a)
Slc8a2 16
Slc8a2 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc8a2 35
  • 89.03 (n)
  • 96.74 (a)
dog
(Canis familiaris)
Mammalia SLC8A2 36
  • 84 (a)
OneToOne
SLC8A2 35
  • 93.81 (n)
  • 98.26 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC8A2 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia SLC8A2 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC8A2 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc8a2 35
  • 68.81 (n)
  • 77.65 (a)
zebrafish
(Danio rerio)
Actinopterygii slc8a2a 36
  • 65 (a)
OneToMany
slc8a2b 36
  • 68 (a)
OneToMany
slc8a2b 35
  • 72.78 (n)
  • 73.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta Calx 37
  • 48 (a)
Calx 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y113G7A.4 37
  • 47 (a)
ncx-1 36
  • 46 (a)
ManyToMany
ncx-2 36
  • 44 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
Species with no ortholog for SLC8A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC8A2 Gene

ENSEMBL:
Gene Tree for SLC8A2 (if available)
TreeFam:
Gene Tree for SLC8A2 (if available)

Paralogs for SLC8A2 Gene

Paralogs for SLC8A2 Gene

(5) SIMAP similar genes for SLC8A2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC8A2: view

Variants for SLC8A2 Gene

Sequence variations from dbSNP and Humsavar for SLC8A2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs17759929 - 47,456,985(+) GTCCA(C/G)GTAGA reference, missense
rs201723439 - 47,466,318(+) GAGGC(A/G)GCAGG reference, missense
rs736533 -- 47,445,489(-) GGAGA(C/G)CTGAA intron-variant
rs746728 -- 47,456,279(-) aggca(C/T)tcagt intron-variant
rs698701 -- 47,456,074(+) TGGTA(C/T)ACCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC8A2 Gene

Variant ID Type Subtype PubMed ID
dgv1107e1 CNV Complex 17122850
nsv428366 CNV Loss 18775914
nsv912201 CNV Loss 21882294
nsv517901 CNV Loss 19592680
esv2718663 CNV Deletion 23290073
nsv912202 CNV Loss 21882294
esv1055822 CNV Deletion 17803354
esv1000004 CNV Deletion 20482838

Variation tolerance for SLC8A2 Gene

Residual Variation Intolerance Score: 4.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC8A2 Gene

HapMap Linkage Disequilibrium report
SLC8A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC8A2 Gene

Disorders for SLC8A2 Gene

Relevant External Links for SLC8A2

Genetic Association Database (GAD)
SLC8A2
Human Genome Epidemiology (HuGE) Navigator
SLC8A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC8A2

No disorders were found for SLC8A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC8A2 Gene

Publications for SLC8A2 Gene

  1. Cloning of the NCX2 isoform of the plasma membrane Na(+)-Ca2+ exchanger. (PMID: 8021246) Li Z. … Philipson K.D. (J. Biol. Chem. 1994) 2 3 23 67
  2. Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins. (PMID: 16679322) Pulina M.V. … Carafoli E. (J. Biol. Chem. 2006) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease. (PMID: 23224884) Wood-Kaczmar A. … Abramov A.Y. (Adv. Exp. Med. Biol. 2013) 3
  5. Immunosuppressive drugs, immunophilins, and functional expression of NCX isoforms. (PMID: 23224887) Rahamimoff H. … Elmaz D. (Adv. Exp. Med. Biol. 2013) 3

Products for SLC8A2 Gene

Sources for SLC8A2 Gene

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