Aliases for SLC8A2 Gene
- Solute Carrier Family 8 Member A2 2 3
- Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 2 2 3 5
- Solute Carrier Family 8 Member 2 3 4
- Na(+)/Ca(2+)-Exchange Protein 2 3 4
- NCX2 3 4
- Solute Carrier Family 8 (Sodium-Calcium Exchanger), Member 2 3
- Na+/Ca2+-Exchanging Protein Nac2 3
- Sodium-Calcium Exchanger 2 3
- KIAA1087 4
External Ids for SLC8A2 Gene
Previous GeneCards Identifiers for SLC8A2 Gene
GeneCards Summary for SLC8A2 Gene
SLC8A2 (Solute Carrier Family 8 Member A2) is a Protein Coding gene. Among its related pathways are Calcium signaling pathway and cGMP-PKG signaling pathway. GO annotations related to this gene include calmodulin binding and calcium:sodium antiporter activity. An important paralog of this gene is ADGRV1.
UniProtKB/Swiss-Prot for SLC8A2 Gene
Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion.
The Na+/Ca2+ exchanger (NCX) is a low affinity, high capacitance calcium antiporter membrane protein that functions to regulate intracellular calcium concentrations. It is located on the plasma, mitochondrial and endoplasmic reticular membranes of excitable cells.