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Aliases for SLC8A2 Gene

Aliases for SLC8A2 Gene

  • Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 2 2 3
  • NCX2 3 4 6
  • Solute Carrier Family 8 Member 2 3 4
  • Na(+)/Ca(2+)-Exchange Protein 2 3 4
  • Solute Carrier Family 8 (Sodium-Calcium Exchanger), Member 2 3
  • Na+/Ca2+-Exchanging Protein Nac2 3
  • Sodium-Calcium Exchanger 2 3
  • Sodium/Calcium Exchanger 2 3
  • KIAA1087 4

External Ids for SLC8A2 Gene

Summaries for SLC8A2 Gene

GeneCards Summary for SLC8A2 Gene

SLC8A2 (Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 2) is a Protein Coding gene. Among its related pathways are CREB Pathway and Platelet homeostasis. GO annotations related to this gene include calmodulin binding and calcium:sodium antiporter activity. An important paralog of this gene is ADGRV1.

UniProtKB/Swiss-Prot for SLC8A2 Gene

  • Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity).

Tocris Summary for SLC8A2 Gene

  • The Na+/Ca2+ exchanger (NCX) is a low affinity, high capacitance calcium antiporter membrane protein that functions to regulate intracellular calcium concentrations. It is located on the plasma, mitochondrial and endoplasmic reticular membranes of excitable cells. Using the electrochemical gradient of Na+, one Ca2+ ion is transported in exchange for three Na+ ions. The Na+/Ca2+ exchanger compliments the high affinity, low capacitance Ca2+-ATPase and together, they are involved in a variety of cellular functions including control of neurosecretion, relaxation of cardiac muscle, maintenance of intracellular Ca2+ stores in the endoplasmic and sarcoplasmic reticuli and excitation-relaxation coupling. Under normal physiological conditions, Na+/Ca2+ exchangers export Ca+ from the cell. However, under cellular stress, such as excitotoxicity, they can switch to reverse mode, which has a protective effect.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC8A2 Gene

Genomics for SLC8A2 Gene

Genomic Location for SLC8A2 Gene

Start:
47,428,017 bp from pter
End:
47,472,168 bp from pter
Size:
44,152 bases
Orientation:
Minus strand

Genomic View for SLC8A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC8A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC8A2 Gene

Regulatory Elements for SLC8A2 Gene

Proteins for SLC8A2 Gene

  • Protein details for SLC8A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPR5-NAC2_HUMAN
    Recommended name:
    Sodium/calcium exchanger 2
    Protein Accession:
    Q9UPR5
    Secondary Accessions:
    • B4DYQ9

    Protein attributes for SLC8A2 Gene

    Size:
    921 amino acids
    Molecular mass:
    100368 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA83039.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC8A2 Gene

Proteomics data for SLC8A2 Gene at MOPED

Post-translational modifications for SLC8A2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn34 and Asn817

Other Protein References for SLC8A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC8A2 Gene

Domains for SLC8A2 Gene

Gene Families for SLC8A2 Gene

UniProtKB/Swiss-Prot:

NAC2_HUMAN
Domain:
  • Contains 2 Calx-beta domains.:
    • Q9UPR5
Family:
  • Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily.:
    • Q9UPR5
genes like me logo Genes that share domains with SLC8A2: view

Function for SLC8A2 Gene

Molecular function for SLC8A2 Gene

GENATLAS Biochemistry: solute carrier family 8 (sodium-calcium exchange),member 2,brain
UniProtKB/Swiss-Prot EnzymeRegulation: By ATP.
UniProtKB/Swiss-Prot Function: Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity).

Gene Ontology (GO) - Molecular Function for SLC8A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005432 calcium:sodium antiporter activity IEA --
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with SLC8A2: view

Phenotypes for SLC8A2 Gene

MGI mutant phenotypes for SLC8A2:
inferred from 1 alleles
GenomeRNAi human phenotypes for SLC8A2:
genes like me logo Genes that share phenotypes with SLC8A2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC8A2 Gene

Localization for SLC8A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC8A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC8A2 Gene COMPARTMENTS Subcellular localization image for SLC8A2 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SLC8A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC8A2: view

Pathways for SLC8A2 Gene

genes like me logo Genes that share pathways with SLC8A2: view

Gene Ontology (GO) - Biological Process for SLC8A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006816 calcium ion transport IEA --
GO:0007154 cell communication IEA --
GO:0007596 blood coagulation TAS --
GO:0035725 sodium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC8A2: view

Compounds for SLC8A2 Gene

(4) Tocris Compounds for SLC8A2 Gene

Compound Action Cas Number
CGP 37157 Antagonist of mitochondrial Na+/Ca2+ exchange [75450-34-9]
KB-R7943 mesylate Na+/Ca2+ exchange inhibitor (reverse mode) [182004-65-5]
SN-6 Selective Na+/Ca2+ exchange inhibitor (reverse mode) [415697-08-4]
YM 244769 Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective [837424-39-2]

(2) HMDB Compounds for SLC8A2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Sodium
  • Sodium
7440-23-5

(2) Novoseek inferred chemical compound relationships for SLC8A2 Gene

Compound -log(P) Hits PubMed IDs
calcium 45.5 15
atp 26.9 1
genes like me logo Genes that share compounds with SLC8A2: view

Transcripts for SLC8A2 Gene

Unigene Clusters for SLC8A2 Gene

Solute carrier family 8 (sodium/calcium exchanger), member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC8A2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for SLC8A2 Gene

GeneLoc Exon Structure for
SLC8A2
ECgene alternative splicing isoforms for
SLC8A2

Expression for SLC8A2 Gene

mRNA expression in normal human tissues for SLC8A2 Gene

mRNA differential expression in normal tissues according to GTEx for SLC8A2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (10.4), Brain - Cerebellum (9.9), Brain - Cortex (5.1), Brain - Frontal Cortex (BA9) (4.6), and Brain - Anterior cingulate cortex (BA24) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC8A2 Gene

SOURCE GeneReport for Unigene cluster for SLC8A2 Gene Hs.172884

genes like me logo Genes that share expressions with SLC8A2: view

Orthologs for SLC8A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC8A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC8A2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC8A2 36
  • 93.92 (n)
  • 98.05 (a)
SLC8A2 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC8A2 36
  • 93.81 (n)
  • 98.26 (a)
SLC8A2 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc8a2 36
  • 88.2 (n)
  • 94.46 (a)
Slc8a2 16
Slc8a2 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC8A2 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 82 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Slc8a2 36
  • 89.03 (n)
  • 96.74 (a)
lizard
(Anolis carolinensis)
Reptilia SLC8A2 37
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc8a2 36
  • 68.81 (n)
  • 77.65 (a)
zebrafish
(Danio rerio)
Actinopterygii slc8a2a 37
  • 65 (a)
OneToMany
slc8a2b 36
  • 72.78 (n)
  • 73.77 (a)
slc8a2b 37
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Calx 37
  • 44 (a)
OneToMany
Calx 38
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea ncx-1 37
  • 46 (a)
ManyToMany
ncx-2 37
  • 44 (a)
ManyToMany
Y113G7A.4 38
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
ManyToMany
-- 37
  • 70 (a)
ManyToMany
Species with no ortholog for SLC8A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC8A2 Gene

ENSEMBL:
Gene Tree for SLC8A2 (if available)
TreeFam:
Gene Tree for SLC8A2 (if available)

Paralogs for SLC8A2 Gene

Paralogs for SLC8A2 Gene

Selected SIMAP similar genes for SLC8A2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC8A2: view

Variants for SLC8A2 Gene

Sequence variations from dbSNP and Humsavar for SLC8A2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs698701 -- 47,456,074(+) TGGTA(C/T)ACCCA intron-variant
rs698702 -- 47,450,680(+) TGTCC(A/G)TGGTG intron-variant
rs698703 -- 47,448,901(+) ccgtt(C/G)tgtgc intron-variant
rs698704 -- 47,448,646(+) TTAAT(A/G)TGCAT intron-variant
rs698705 -- 47,434,209(+) GCATC(A/G)CTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC8A2 Gene

Variant ID Type Subtype PubMed ID
dgv1107e1 CNV Complex 17122850
nsv428366 CNV Loss 18775914
nsv912201 CNV Loss 21882294
nsv517901 CNV Loss 19592680
esv2718663 CNV Deletion 23290073
nsv912202 CNV Loss 21882294
esv1055822 CNV Deletion 17803354
esv1000004 CNV Deletion 20482838

Relevant External Links for SLC8A2 Gene

HapMap Linkage Disequilibrium report
SLC8A2

Disorders for SLC8A2 Gene

(1) University of Copenhagen DISEASES for SLC8A2 Gene

(1) Novoseek inferred disease relationships for SLC8A2 Gene

Disease -log(P) Hits PubMed IDs
ischemia 20.3 1

Relevant External Links for SLC8A2

Genetic Association Database (GAD)
SLC8A2
Human Genome Epidemiology (HuGE) Navigator
SLC8A2
genes like me logo Genes that share disorders with SLC8A2: view

No data available for UniProtKB/Swiss-Prot for SLC8A2 Gene

Publications for SLC8A2 Gene

  1. Cloning of the NCX2 isoform of the plasma membrane Na(+)-Ca2+ exchanger. (PMID: 8021246) Li Z. … Philipson K.D. (J. Biol. Chem. 1994) 2 3 23
  2. Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins. (PMID: 16679322) Pulina M.V. … Carafoli E. (J. Biol. Chem. 2006) 3 23
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 3 4
  5. Calcineurin inhibits Na+/Ca2+ exchange in phenylephrine-treated hypertrophic cardiomyocytes. (PMID: 15557343) Katanosaka Y. … Shigekawa M. (J. Biol. Chem. 2005) 3

Products for SLC8A2 Gene

Sources for SLC8A2 Gene

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