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Aliases for SLC8A1 Gene

Aliases for SLC8A1 Gene

  • Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1 2 3
  • NCX1 3 4 6
  • Solute Carrier Family 8 Member 1 3 4
  • Na(+)/Ca(2+)-Exchange Protein 1 3 4
  • Na+/Ca++ Exchanger 2 3
  • Sodium/Calcium Exchanger 1 3
  • Na+/Ca2+ Exchanger 3
  • CNC 4

External Ids for SLC8A1 Gene

Previous HGNC Symbols for SLC8A1 Gene

  • NCX1

Previous GeneCards Identifiers for SLC8A1 Gene

  • GC02M040318
  • GC02M040500
  • GC02M040316
  • GC02M040253
  • GC02M040339

Summaries for SLC8A1 Gene

Entrez Gene Summary for SLC8A1 Gene

  • In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]

GeneCards Summary for SLC8A1 Gene

SLC8A1 (Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1) is a Protein Coding gene. Diseases associated with SLC8A1 include aromatase deficiency. Among its related pathways are CREB Pathway and Platelet homeostasis. GO annotations related to this gene include calmodulin binding and cytoskeletal protein binding. An important paralog of this gene is ADGRV1.

UniProtKB/Swiss-Prot for SLC8A1 Gene

  • Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.

Tocris Summary for SLC8A1 Gene

  • The Na+/Ca2+ exchanger (NCX) is a low affinity, high capacitance calcium antiporter membrane protein that functions to regulate intracellular calcium concentrations. It is located on the plasma, mitochondrial and endoplasmic reticular membranes of excitable cells. Using the electrochemical gradient of Na+, one Ca2+ ion is transported in exchange for three Na+ ions. The Na+/Ca2+ exchanger compliments the high affinity, low capacitance Ca2+-ATPase and together, they are involved in a variety of cellular functions including control of neurosecretion, relaxation of cardiac muscle, maintenance of intracellular Ca2+ stores in the endoplasmic and sarcoplasmic reticuli and excitation-relaxation coupling. Under normal physiological conditions, Na+/Ca2+ exchangers export Ca+ from the cell. However, under cellular stress, such as excitotoxicity, they can switch to 'reverse mode', which has a protective effect.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC8A1 Gene

Genomics for SLC8A1 Gene

Regulatory Elements for SLC8A1 Gene

Genomic Location for SLC8A1 Gene

Start:
40,097,270 bp from pter
End:
40,611,053 bp from pter
Size:
513,784 bases
Orientation:
Minus strand

Genomic View for SLC8A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC8A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC8A1 Gene

Proteins for SLC8A1 Gene

  • Protein details for SLC8A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32418-NAC1_HUMAN
    Recommended name:
    Sodium/calcium exchanger 1
    Protein Accession:
    P32418
    Secondary Accessions:
    • A8K6N1
    • D6W595
    • O95849
    • Q4QQG6
    • Q587I6
    • Q59GN4
    • Q9UBL8
    • Q9UD55
    • Q9UDN1
    • Q9UDN2
    • Q9UKX6

    Protein attributes for SLC8A1 Gene

    Size:
    973 amino acids
    Molecular mass:
    108547 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH98308.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC8A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC8A1 Gene

Proteomics data for SLC8A1 Gene at MOPED

Post-translational modifications for SLC8A1 Gene

  • Glycosylation at Asn44 and Asn160
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC8A1 Gene

Domains for SLC8A1 Gene

Gene Families for SLC8A1 Gene

Suggested Antigen Peptide Sequences for SLC8A1 Gene

Graphical View of Domain Structure for InterPro Entry

P32418

UniProtKB/Swiss-Prot:

NAC1_HUMAN :
  • P32418
Domain:
  • Contains 2 Calx-beta domains.
Family:
  • Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily.
genes like me logo Genes that share domains with SLC8A1: view

Function for SLC8A1 Gene

Molecular function for SLC8A1 Gene

GENATLAS Biochemistry: solute carrier family 8 (sodium-calcium exchange),member 1,cardiac,expressed in sarcolemma
UniProtKB/Swiss-Prot EnzymeRegulation: By ATP
UniProtKB/Swiss-Prot Function: Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.

Gene Ontology (GO) - Molecular Function for SLC8A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005432 calcium:sodium antiporter activity IDA 1374913
GO:0005515 protein binding --
GO:0005516 calmodulin binding IEA --
GO:0008092 cytoskeletal protein binding IDA 16292983
GO:0030506 ankyrin binding ISS --
genes like me logo Genes that share ontologies with SLC8A1: view
genes like me logo Genes that share phenotypes with SLC8A1: view

Animal Models for SLC8A1 Gene

MGI Knock Outs for SLC8A1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC8A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC8A1 Gene

Localization for SLC8A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC8A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC8A1 Gene COMPARTMENTS Subcellular localization image for SLC8A1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 3
cytoskeleton 2
cytosol 2
extracellular 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for SLC8A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 19095005
GO:0005887 integral component of plasma membrane IDA 1374913
GO:0014704 intercalated disc TAS 17614935
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC8A1: view

Pathways for SLC8A1 Gene

genes like me logo Genes that share pathways with SLC8A1: view

Gene Ontology (GO) - Biological Process for SLC8A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001892 embryonic placenta development IEA --
GO:0002026 regulation of the force of heart contraction ISS --
GO:0002027 regulation of heart rate ISS --
GO:0003007 heart morphogenesis IEA --
GO:0006811 ion transport TAS --
genes like me logo Genes that share ontologies with SLC8A1: view

Compounds for SLC8A1 Gene

(4) Tocris Compounds for SLC8A1 Gene

Compound Action Cas Number
CGP 37157 Antagonist of mitochondrial Na+/Ca2+ exchange [75450-34-9]
KB-R7943 mesylate Na+/Ca2+ exchange inhibitor (reverse mode) [182004-65-5]
SN-6 Selective Na+/Ca2+ exchange inhibitor (reverse mode) [415697-08-4]
YM 244769 Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective [837424-39-2]

(2) HMDB Compounds for SLC8A1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Sodium
  • Sodium
7440-23-5

(2) Drugbank Compounds for SLC8A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-Linolenic Acid
  • (9Z,12Z,15Z)-Octadecatrienoic acid
463-40-1 target
Icosapent
  • Eicosapentaenoic acid
10417-94-4 target inhibitor

(74) Novoseek inferred chemical compound relationships for SLC8A1 Gene

Compound -log(P) Hits PubMed IDs
sea 0400 85.5 5
2,4-dichlorobenzamil 83.4 1
3,4-dichlorobenzamil 83.2 5
p-mca 83 11
bepridil 82.5 7
genes like me logo Genes that share compounds with SLC8A1: view

Transcripts for SLC8A1 Gene

Unigene Clusters for SLC8A1 Gene

Solute carrier family 8 (sodium/calcium exchanger), member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC8A1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC8A1 Gene

No ASD Table

Relevant External Links for SLC8A1 Gene

GeneLoc Exon Structure for
SLC8A1
ECgene alternative splicing isoforms for
SLC8A1

Expression for SLC8A1 Gene

mRNA expression in normal human tissues for SLC8A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC8A1 Gene

This gene is overexpressed in Heart - Left Ventricle (12.0) and Heart - Atrial Appendage (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC8A1 Gene

SOURCE GeneReport for Unigene cluster for SLC8A1 Gene Hs.31961

mRNA Expression by UniProt/SwissProt for SLC8A1 Gene

P32418-NAC1_HUMAN
Tissue specificity: Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung.
genes like me logo Genes that share expressions with SLC8A1: view

In Situ Assay Products

Orthologs for SLC8A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC8A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC8A1 35
  • 99.69 (n)
  • 99.69 (a)
SLC8A1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC8A1 35
  • 91.96 (n)
  • 97.32 (a)
SLC8A1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC8A1 35
  • 93.31 (n)
  • 97.94 (a)
SLC8A1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc8a1 35
  • 89.59 (n)
  • 95.05 (a)
Slc8a1 16
Slc8a1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC8A1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc8a1 35
  • 89.42 (n)
  • 95.26 (a)
chicken
(Gallus gallus)
Aves NCX1 36
  • 89 (a)
OneToOne
SLC8A1 35
  • 80.43 (n)
  • 90.51 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 92 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
SLC8A1 36
  • 94 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.23650 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc8a1 35
  • 78.93 (n)
  • 88.95 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11654 35
zebrafish
(Danio rerio)
Actinopterygii Dr.19052 35
slc8a1a 36
  • 76 (a)
OneToMany
slc8a1b 35
  • 71.44 (n)
  • 80.13 (a)
slc8a1b 36
  • 79 (a)
OneToMany
slc8a4a 36
  • 69 (a)
OneToMany
slc8a4b 36
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Calx 36
  • 45 (a)
OneToMany
Calx 37
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea ncx-1 35
  • 54.05 (n)
  • 50.91 (a)
ncx-1 36
  • 49 (a)
ManyToMany
ncx-2 36
  • 45 (a)
ManyToMany
ncx-2 37
  • 45 (a)
Y113G7A.4 37
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
Species with no ortholog for SLC8A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC8A1 Gene

ENSEMBL:
Gene Tree for SLC8A1 (if available)
TreeFam:
Gene Tree for SLC8A1 (if available)

Paralogs for SLC8A1 Gene

Paralogs for SLC8A1 Gene

Selected SIMAP similar genes for SLC8A1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC8A1: view

Variants for SLC8A1 Gene

Sequence variations from dbSNP and Humsavar for SLC8A1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs23055 -- 40,265,530(-) TTTCT(C/G)ATCAG intron-variant
rs366578 -- 40,256,500(+) TGGGA(G/T)TGATT intron-variant
rs368161 -- 40,265,175(-) CCATC(C/G)TCTAC intron-variant
rs368248 -- 40,259,901(+) CTGCT(C/G)GCTGC intron-variant
rs381627 -- 40,260,454(-) TAAGT(C/G)AATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC8A1 Gene

Variant ID Type Subtype PubMed ID
nsv833892 CNV Loss 17160897
dgv4094n71 CNV Gain 21882294
nsv873903 CNV Gain 21882294
nsv873905 CNV Loss 21882294
dgv4095n71 CNV Loss 21882294
nsv873908 CNV Loss 21882294
nsv873909 CNV Loss 21882294
nsv873910 CNV Gain 21882294
dgv215n21 CNV Loss 19592680
nsv873911 CNV Gain 21882294
esv2719954 CNV Deletion 23290073
esv2719955 CNV Deletion 23290073
esv2719956 CNV Deletion 23290073
esv34071 CNV Loss 18971310
esv2719957 CNV Deletion 23290073
esv4917 CNV Deletion 18987735
esv2719958 CNV Deletion 23290073
esv995388 CNV Deletion 20482838
esv1125657 CNV Deletion 17803354
esv2719959 CNV Deletion 23290073
nsv524586 CNV Loss 19592680
nsv873912 CNV Loss 21882294
nsv873913 CNV Loss 21882294
esv2719960 CNV Deletion 23290073
esv2719961 CNV Deletion 23290073
esv2234750 CNV Deletion 18987734
esv2719963 CNV Deletion 23290073
esv991008 CNV Deletion 20482838
esv1427276 CNV Deletion 17803354
dgv1179e1 CNV Complex 17122850
esv2536757 CNV Deletion 19546169
nsv873914 CNV Loss 21882294
nsv873915 CNV Loss 21882294
nsv516330 CNV Loss 19592680
nsv2698 CNV Insertion 18451855
nsv873916 CNV Gain 21882294
nsv9658 CNV Loss 18304495
esv25665 CNV Loss 19812545
esv2672782 CNV Deletion 23128226
esv274519 CNV Insertion 20981092
esv270790 CNV Insertion 20981092
nsv2700 CNV Loss 18451855
nsv873917 CNV Gain 21882294

Relevant External Links for SLC8A1 Gene

HapMap Linkage Disequilibrium report
SLC8A1
Human Gene Mutation Database (HGMD)
SLC8A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC8A1 Gene

Disorders for SLC8A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SLC8A1 Gene including...

Search for SLC8A1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SLC8A1 Gene

(15) Novoseek inferred disease relationships for SLC8A1 Gene

Disease -log(P) Hits PubMed IDs
cardiac hypertrophy 48 2
heart failure 43.5 7
cell damage 34.7 6
arrhythmia 33.9 2
hypertrophy 26.2 4

Relevant External Links for SLC8A1

Genetic Association Database (GAD)
SLC8A1
Human Genome Epidemiology (HuGE) Navigator
SLC8A1
genes like me logo Genes that share disorders with SLC8A1: view

No data available for UniProtKB/Swiss-Prot for SLC8A1 Gene

Publications for SLC8A1 Gene

  1. Mapping of the gene for the cardiac sarcolemmal Na(+)-Ca2+ exchanger to human chromosome 2p21-p23. (PMID: 1559714) Shieh B.H. … Philipson K.D. (Genomics 1992) 2 3 23
  2. Molecular cloning and characterization of the human cardiac Na+/Ca2+ exchanger cDNA. (PMID: 1374913) Komuro I. … Izumo S. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4 23
  3. Association of genetic polymorphisms of sodium-calcium exchanger 1 gene, NCX1, with hypertension in a Japanese general population. (PMID: 15785003) Kokubo Y. … Miyata T. (Hypertens. Res. 2004) 3 23 48
  4. NCX1 Na/Ca exchanger splice variants in pancreatic islet cells. (PMID: 11241183) Van Eylen F. … Herchuelz A. (J. Endocrinol. 2001) 3 4 23
  5. Hypervariable intronic region in NCX1 is enriched in short insertion-deletion polymorphisms and showed association with cardiovascular traits. (PMID: 20109173) Kepp K. … Laan M. (BMC Med. Genet. 2010) 3 23 48

Products for SLC8A1 Gene

  • antibodies-online peptides for SLC8A1
  • antibodies-online antibodies for SLC8A1
  • antibodies-online kits for SLC8A1

Sources for SLC8A1 Gene

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