Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC7A8 Gene

protein-coding   GIFtS: 60
GCID: GC14M023594

Solute Carrier Family 7 (Amino Acid Transporter Light Chain,...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 7 (Amino Acid Transporter Light Chain, L System),
Member 81 2
     Large Neutral Amino Acids Transporter Small Subunit 22
LAT22 3 5     Solute Carrier Family 7 (Amino Acid Transporter, L-Type), Member 82
L-Type Amino Acid Transporter 22 3     Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System),
Member 82
LPI-PC12     hLAT23
Integral Membrane Protein E16H2     Solute Carrier Family 7 Member 83

External Ids:    HGNC: 110661   Entrez Gene: 234282   Ensembl: ENSG000000920687   OMIM: 6042355   UniProtKB: Q9UHI53   

Export aliases for SLC7A8 gene to outside databases

Previous GC identifers: GC14M020966 GC14M017381 GC14M021584 GC14M022664 GC14M003711


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC7A8 Gene: 
SLC7A8 (solute carrier family 7 (amino acid transporter light chain, L system), member 8) is a protein-coding gene. Diseases associated with SLC7A8 include lysinuric protein intolerance, and cystinuria, and among its related super-pathways are Amino acid transport across the plasma membrane and Transmembrane transport of small molecules. GO annotations related to this gene include neutral amino acid transmembrane transporter activity and peptide antigen binding. An important paralog of this gene is SLC7A7.

UniProtKB/Swiss-Prot: LAT2_HUMAN, Q9UHI5
Function: Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine,
serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with
SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower
affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in
basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when
administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and
toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective
transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of
neutral amino acids from the epithelial cells to the bloodstream in the kidney

Gene Wiki entry for SLC7A8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC7A8 gene promoter:
         MZF-1   PPAR-gamma1   FAC1   AML1a   Ik-2   HSF2   Sox9   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC7A8 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC7A8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC7A8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

SLC7A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC7A8 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M023594:  view genomic region     (about GC identifiers)

Start:
23,594,504 bp from pter      End:
23,652,883 bp from pter
Size:
58,380 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LAT2_HUMAN, Q9UHI5 (See protein sequence)
Recommended Name: Large neutral amino acids transporter small subunit 2  
Size: 535 amino acids; 58382 Da
Subunit: Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc
Subcellular location: Cytoplasm. Basolateral cell membrane; Multi-pass membrane protein. Note=Localized to the
cytoplasm when expressed alone but when coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane.
Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine
epithelia of the villi
Miscellaneous: L-leucine transport activity inhibited by small zwitterionic amino acids (i.e. glycine, alanine,
serine, threonine asparginine, glutamine, methionine, leucine, isoleucine, valine, phenylalanine, tyrosine,
tryptophan, histidine and cysteine) and by glutamine and asparginine. Methionine uptake was inhibited by the
L-system substrates L-leucine, 2-amino-bicyclo-(2,2,1)-heptane-2-carboxylate (BCH), L-cysteine and by the
MeHg-L-cysteine complex and structurally related S-ethyl-L-cysteine. MeHg-L-cysteine uptake is inhibited by
L-methionine, L-leucine, BCH and S-ethyl-L-cysteine. L-leucine uptake was inhibited by L-CNSO
Sequence caution: Sequence=CAD62616.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2R8Q4 B4DKT4 B4DTV6 D3DS46 F2Z2J4 Q86U05 Q9UKQ6 Q9UKQ7 Q9UKQ8 Q9Y445
Alternative splicing: 4 isoforms:  Q9UHI5-1   Q9UHI5-2   Q9UHI5-3   Q9UHI5-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC7A8: NX_Q9UHI5

Explore proteomics data for SLC7A8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UHI5

  • SLC7A8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC7A8 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001253965.1  NP_001253966.1  NP_036376.2  NP_877392.1  

    ENSEMBL proteins: 
     ENSP00000343949   ENSP00000320378   ENSP00000435114   ENSP00000391577   ENSP00000434345  
     ENSP00000435865   ENSP00000434352   ENSP00000436665   ENSP00000416398  
    Reactome Protein details: Q9UHI5
    Human Recombinant Protein Products for SLC7A8: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SLC7A8
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SLC7A8
    GenScript Custom Purified and Recombinant Proteins Services for SLC7A8
    Novus Biologicals SLC7A8 Proteins
    Novus Biologicals SLC7A8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS10391915
    GO:0016020membrane ----
    GO:0016021integral to membrane ----

    SLC7A8 for ontologies           About GeneDecksing



    SLC7A8 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SLC7A8
    OriGene Custom Antibody Services for SLC7A8
    GenScript Custom Superior Antibodies Services for SLC7A8
    Novus Biologicals SLC7A8 Antibodies
    Abcam antibodies for SLC7A8
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for SLC7A8
    LSBio Antibodies in human, mouse, rat for SLC7A8 

    Assay Products for SLC7A8: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC7A8
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC7A8
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: L-type amino acid transporter 2 
    SLC7 family

    2 InterPro protein domains:
     IPR002293 AA/rel_permease1
     IPR004760 L_AA_transporter

    Graphical View of Domain Structure for InterPro Entry Q9UHI5

    ProtoNet protein and cluster: Q9UHI5

    UniProtKB/Swiss-Prot: LAT2_HUMAN, Q9UHI5
    Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter
    (LAT) (TC 2.A.3.8) family


    SLC7A8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LAT2_HUMAN, Q9UHI5
    Function: Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine,
    serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with
    SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower
    affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in
    basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when
    administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and
    toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective
    transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of
    neutral amino acids from the epithelial cells to the bloodstream in the kidney
    Biophysicochemical properties: Kinetic parameters: KM=221 uM for L-leucine; KM=64 uM for MeHg-L-cysteine; KM=161
    uM for methionine; KM=978 uM for L-alanine; KM=89.35 uM for L-phenylalanine; KM=57.3 uM for L-tryptophan; KM=48.8
    uM for L-tyrosine;
    Induction: Activity in polarized intestinal cells is regulated by the association between SLC3A2/4F2 (in the
    SLC3A2/4F2-LAT2 heterodimer) and ICAM1

         Genatlas biochemistry entry for SLC7A8:
    solute carrier family 7 member 8,cation aminoacid transport,highly expressed in skeletal
    muscle,intestine,kidney,placenta and in retinal pigmented epithelium,heterodimerizing with the cell surface
    glycoprotein 4F2hc/CD98 at the basolateral membrane to form a complex mediating y+L-type transporter exchanging
    cationic aminoacids and/or neutral aminoacids together with sodium,glycoprotein associated aminoacid transporter
    family,not mutated in lysinuric protein intolerance

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12716892
    GO:0015101organic cation transmembrane transporter activity IDA12117417
    GO:0015171amino acid transmembrane transporter activity ISS--
    GO:0015175neutral amino acid transmembrane transporter activity TAS10391915
    GO:0015179L-amino acid transmembrane transporter activity IEA--
         
    SLC7A8 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc7a8):
     behavior/neurological  nervous system 

    SLC7A8 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC7A8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC7A8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC7A8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC7A8 

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC7A8:
    hsa-mir-155 (MIRT005092)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC7A8
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC7A8 (see all 41):
    hsa-miR-548j hsa-miR-486-3p hsa-miR-766 hsa-miR-124 hsa-miR-9 hsa-miR-133a hsa-miR-3613-3p hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC7A8 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC7A8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC7A8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC7A8
    Sirion Biotech Customized adenovirus for overexpression of SLC7A8

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SLC7A8 (see all 14)
    OriGene ORF clones in mouse, rat for SLC7A8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC7A8 (NM_182728)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC7A8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC7A8
    Sirion Biotech Customized lentivirus for stable overexpression of SLC7A8 
                         Customized lentivirus expression plasmids for stable overexpression of SLC7A8 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC7A8
    Search LifeMap BioReagents cell lines for SLC7A8
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC7A8 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Amino acid and oligopeptide SLC transporters
    Amino acid and oligopeptide SLC transporters0.63
    Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    Amino acid transport across the plasma membrane0.63
    2SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50
    3Platelet activation, signaling and aggregation
    Hemostasis0.43
    4Protein digestion and absorption
    Protein digestion and absorption
    5Basigin interactions
    Basigin interactions

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/8        Reactome Pathways for SLC7A8 (see all 8)
        Hemostasis
    Transmembrane transport of small molecules
    SLC-mediated transmembrane transport
    Amino acid and oligopeptide SLC transporters
    Transport of inorganic cations/anions and amino acids/oligopeptides


    1         Kegg Pathway  (Kegg details for SLC7A8):
        Protein digestion and absorption


    SLC7A8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC7A8

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLC7A8 (Q9UHI53 ENSP000003203784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAATQ140323, ENSP000002594074I2D: score=1 STRING: ENSP00000259407
    SLC3A1Q078373, ENSP000002606494I2D: score=1 STRING: ENSP00000260649
    SLC3A2P081953, ENSP000003671244I2D: score=2 STRING: ENSP00000367124
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003333amino acid transmembrane transport ----
    GO:0006520cellular amino acid metabolic process TAS10391915
    GO:0006810transport TAS10391915
    GO:0006811ion transport TAS--
    GO:0006865amino acid transport TAS--

    SLC7A8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC7A8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC7A8 (LAT2)

    6 HMDB Compounds for SLC7A8    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Alanine(2S)-2-Aminopropanoate (see all 35)56-41-7--
    L-Cysteine(+)-2-Amino-3-mercaptopropionic acid (see all 37)52-90-4--
    L-Glutamine(2S)-2,5-diamino-5-oxopentanoic acid (see all 31)56-85-9--
    L-Leucine(2S)-2-Amino-4-methylpentanoate (see all 16)61-90-5--
    L-Phenylalanine(-)-beta-Phenylalanine (see all 28)63-91-2--
    SodiumSodium (see all 2)7440-23-5--

    5 DrugBank Compounds for SLC7A8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamine(S)-2,5-diamino-5-oxopentanoic acid (see all 4)56-85-9transportersubstrate16785209 17273864 16308696 17504263 16249471
    L-Phenylalanine(S)-alpha-Amino-beta-phenylpropionic acid (see all 4)63-91-2target--12930836 10574970 12101005 9349567 12498902
    L-Alanine(2S)-2-Aminopropanoic acid (see all 15)56-41-7target--17504263
    Levodopa3,4-dihydroxyphenylalanine (see all 4)59-92-7transporter--15200428
    S-(Methylmercury)-L-Cysteine-- --transporter--12117417

    9 Novoseek inferred chemical compound relationships for SLC7A8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-aminobicyclo(2,2,1)heptane-2-carboxylic acid 93.4 1 10391915 (1)
    leucine 65.1 4 19890975 (2), 15863273 (1)
    l-amino acid 63.9 5 10673541 (1), 10391915 (1), 11230513 (1)
    melphalan 56.7 8 17558306 (4), 19075510 (1), 19447222 (1)
    cystine 52.1 4 12660317 (3)
    phenylalanine 34.9 3 17558306 (1), 10574970 (1)
    alanine 26.5 2 12660317 (1), 10574970 (1)
    cysteine 16.5 3 12660317 (2)
    threonine 15.4 1 12660317 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC7A8 / LAT2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC7A8 gene (4 alternative transcripts): 
    NM_001267036.1  NM_001267037.1  NM_012244.3  NM_182728.2  

    Unigene Cluster for SLC7A8:

    Solute carrier family 7 (amino acid transporter light chain, L system), member 8
    Hs.596643  [show with all ESTs]
    Unigene Representative Sequence: NM_012244
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339733(uc001wiy.3) ENST00000316902(uc001wix.3 uc010tnk.2 uc010tnl.2 uc001wiz.3 uc010akj.3)
    ENST00000397310(uc001wiw.3) ENST00000469263 ENST00000453702 ENST00000529705
    ENST00000528860 ENST00000528806 ENST00000528186 ENST00000532568 ENST00000524758
    ENST00000525062 ENST00000422941
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC7A8
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC7A8 (see all 41):
    hsa-miR-548j hsa-miR-486-3p hsa-miR-766 hsa-miR-124 hsa-miR-9 hsa-miR-133a hsa-miR-3613-3p hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC7A8 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC7A8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC7A8
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC7A8 (see all 14)
    OriGene ORF clones in mouse, rat for SLC7A8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC7A8 (NM_182728)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC7A8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC7A8
    Sirion Biotech Customized lentivirus for stable overexpression of SLC7A8 
                         Customized lentivirus expression plasmids for stable overexpression of SLC7A8 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC7A8
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC7A8
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC7A8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC7A8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC7A8

    Additional mRNA sequence: 

    AB037669.1 AF087908.1 AF087911.1 AF135828.1 AF135829.1 AF135830.1 AF171669.1 AK223610.1 
    AK296702.1 AK300384.1 AK307609.1 AK313465.1 AL365342.1 AL365343.2 AL365344.1 AL365345.1 
    AL365346.1 AL365347.1 AL365414.1 BC036825.1 BC052250.1 BX248288.1 NR_049767.1 Y18483.1 

    23 DOTS entries:

    DT.311443  DT.100697969  DT.92441563  DT.100791464  DT.92441552  DT.101982645  DT.100791459  DT.100791465 
    DT.95184464  DT.75200329  DT.101982647  DT.100791463  DT.120748368  DT.120748434  DT.95204226  DT.95257171 
    DT.100791466  DT.120748335  DT.120748412  DT.91748546  DT.91906748  DT.92441555  DT.120748487 

    24/264 AceView cDNA sequences (see all 264):

    BM705117 BU145374 BM672955 BM699297 CA417408 BU846479 CK819644 BM967127 
    AI671044 CB178024 CD671134 R81562 CK819645 AW273801 AL694782 BU735576 
    BG403071 NM_012244 NM_182728 BF058899 AI249760 BC036825 BM129717 N26363 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A8 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b
    SP1:                                                              -     -     -                       -                 -           -     -                     
    SP2:                                                                          -                 -     -     -           -           -                           
    SP3:                                                              -     -     -                 -     -     -     -     -     -     -     -     -               
    SP4:                                                                          -                                                                                 
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for SLC7A8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC7A8 expression in normal human tissues (normalized intensities)      SLC7A8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTCTTGGG
    SLC7A8 Expression
    About this image


    SLC7A8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
             Human corneal endothelial cells
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Human corneal endothelial cells
             Human Retinal Pigment Epithelial Cells (HRPEpiC)   
     
     Blood Brain Barrier (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier

    See SLC7A8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC7A8

    SOURCE GeneReport for Unigene cluster: Hs.596643

    UniProtKB/Swiss-Prot: LAT2_HUMAN, Q9UHI5
    Tissue specificity: Strongest expression is observed in kidney and moderate expression in placenta and brain,
    followed by liver, prostate, testis, ovary, lymph node, thymus, spleen, skeletal muscle and heart. Also expressed
    in fetal liver as well as in the retinal pigment epithelial cell line ARPE-19 and the intestinal epithelial cell
    line Caco-2

        SABiosciences Expression via Pathway-Focused PCR Array including SLC7A8: 
              Drug Transporters in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC7A8
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC7A8
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC7A8
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC7A8
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC7A8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC7A8 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc7a81 , 5 solute carrier family 7 (cationic amino acid transporter, more1, 5 89.92(n)1
    93.38(a)1
      14 (27.91 cM)5
    509341  NM_016972.21  NP_058668.11 
     547222165 
    lizard
    (Anolis carolinensis)
    Reptilia SLC7A86
    Uncharacterized protein
    83(a)
    1 ↔ 1
    GL343776.1(37418-55327)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044971.12   -- 80.52(n)    BC044971.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-14a17.31 si:ch211-14a17.3 75.72(n)
    84.77(a)
      100007704  XM_001344060.3  XP_001344096.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mnd3
    CG16071
    amino acid transporter3
    CG16071
    50(a)
    (best of 3)3
    56.63(n)1
    51.02(a)1
      437071  NM_143608.11  NP_651865.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F27C8.13
    aat-11
    integral membrane protein E16 like3
    Protein AAT-11
    47(a)
    (best of 8)3
    52.77(n)1
    48.46(a)1
      IV(9599614-9601874)3
    1777931  NM_069306.31  NP_501707.11 


    ENSEMBL Gene Tree for SLC7A8 (if available)
    TreeFam Gene Tree for SLC7A8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC7A8 gene
    SLC7A72  SLC7A62  SLC7A112  SLC7A92  SLC7A52  SLC7A132  SLC7A102  
    14 SIMAP similar genes for SLC7A8 using alignment to 6 protein entries:     LAT2_HUMAN (see all proteins):
    SLC7A10    SLC7A5    SLC7A6    lat1    SLC7A5P1    DKFZp686K14185
    SLC7A5P2    SLC7A7    SLC7A9    xCT    hxCT    SLC7A11
    SLC7A1    SLC7A13

    SLC7A8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1299 SNPs in SLC7A8 are shown (see all 1299)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1422966171,2
    C--3771835(+) AAGATC/TGCACC 1 -- us2k10--------
    rs736004361,2
    C--3771975(+) TCTCTG/TTAGGT 1 -- us2k14Minor allele frequency- T:0.14WA CSA NA 241
    rs171274931,2
    C,F,H--3772076(+) ATATGT/CTGACA 1 -- us2k112Minor allele frequency- C:0.06NA NS EA WA CSA 923
    rs1497328411,2
    --3772198(+) GCTCTC/TGGCTC 1 -- us2k10--------
    rs726843541,2
    C--3772231(+) TTCAAG/ATGATT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs104381261,2
    C--23594011(+) tttatC/Tttttg 5 -- int14Minor allele frequency- T:0.12NA WA EA 360
    rs1441505931,2
    C--23594050(+) GGCTGA/GTCTCA 5 -- int10--------
    rs1153935441,2
    C,F--23594110(+) GATTAC/TGGGAG 5 -- int11Minor allele frequency- T:0.03WA 118
    rs1115473421,2
    C,F--23594111(+) ATTACG/AGGAGT 5 -- int11Minor allele frequency- A:0.50NA 2
    rs1838024721,2
    --23594124(+) GCCGCC/TGTGCC 5 -- int10--------

    HapMap Linkage Disequilibrium report for SLC7A8 (23594504 - 23652883 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLC7A8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1215CNV Insertion18451855
    nsv901492CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC7A8
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC7A8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604235    OMIM disorders: --

    12 diseases for SLC7A8:    About MalaCards
    lysinuric protein intolerance    cystinuria    leiomyoma    oral cancer
    retinitis    cerebritis    sarcoma    thyroiditis
    endotheliitis    breast cancer    neuronitis    prostatitis


    SLC7A8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC7A8
    Human Genome Epidemiology (HuGE) Navigator: SLC7A8 (7 documents)

    Export disorders for SLC7A8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC7A8 gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with SLC7A8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. (PubMed id 10391915)1, 2, 3, 9 Pineda M.... Palacin M. (1999)
    2. LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine. (PubMed id 10574970)1, 2, 7, 9 Rossier G....Kuhn L.C. (1999)
    3. Transport of a neurotoxicant by molecular mimicry: the methylmercury- L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2. (PubMed id 12117417)1, 2, 7 Simmons-Willis T.A.... Ballatori N. (2002)
    4. SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance. (PubMed id 10080183)1, 2, 3 Borsani G....Sebastio G. (1999)
    5. Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan. (PubMed id 17558306)1, 4, 9 Kuhne A....Brockmoller J. (2007)
    6. Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule. (PubMed id 15918515)1, 2, 9 Park S.Y....Kim D.K. (2005)
    7. Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols. (PubMed id 15769744)1, 2, 9 Li S. and Whorton A.R. (2005)
    8. Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains. (PubMed id 11311135)1, 2, 9 Broeer A.... Broeer S. (2001)
    9. CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia. (PubMed id 12716892)1, 2, 9 Liu X....Merlin D. (2003)
    10. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23428 HGNC: 11066 AceView: SLC7A8 Ensembl:ENSG00000092068 euGenes: HUgn23428
    ECgene: SLC7A8 Kegg: 23428 H-InvDB: SLC7A8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC7A8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC7A8 gene:
    Search GeneIP for patents involving SLC7A8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SLC7A8   OriGene RNAi products in human, mouse, rat for SLC7A8  
     OriGene qPCR primer pairs and template standards for SLC7A8   OriGene Protein Over-expression Lysate for SLC7A8  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC7A8  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC7A8   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC7A8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC7A8   OriGene Custom Protein Services for SLC7A8  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC7A8
     QIAGEN SeqTarget long-range PCR primers for resequencing SLC7A8
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC7A8
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC7A8
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC7A8
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC7A8
     GenScript Custom Purified and Recombinant Proteins Services for SLC7A8 GenScript cDNA clones with any tag delivered in your preferred vector for SLC7A8
     GenScript Custom Assay Services for SLC7A8 GenScript Custom Superior Antibodies Services for SLC7A8
     GenScript Custom overexpressing Cell Line Services for SLC7A8 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SLC7A8 promoter
     Search Chromatin IP Primers for SLC7A8
     RT2 qPCR Primer Assay in human, mouse, rat SLC7A8
     GNC Network for SLC7A8
     SABiosciences PCR Arrays including human, mouse, rat SLC7A8
     Search Tocris compounds for SLC7A8 (LAT2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SLC7A8 antibodies
     SLC7A8 proteins
     SLC7A8 lysates
     Antibodies for SLC7A8
     See all of Abcam's Antibodies, Kits and Proteins for SLC7A8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for SLC7A8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC7A8
     SwitchGear 3'UTR luciferase reporter plasmids for SLC7A8
     SwitchGear Promoter luciferase reporter plasmids for SLC7A8
     Search ThermoFisher Antibodies for SLC7A8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC7A8
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC7A8
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC7A8
    Customized:
     lentivirus for stable overexpression of SLC7A8
     lentivirus expression plasmids for stable overexpression of SLC7A8
     adenovirus for overexpression of SLC7A8
     LSBio Antibodies in human, mouse, rat for SLC7A8
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC7A8 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4